Digital Commons Network^™

Using Visual Discharge Instructions: How Comics Can Improve Healthcare And Outcomes For Limited English Proficient Patients, Alexandra R. Streeter

Honors Thesis

The purpose of this thesis is to demonstrate how graphic medicine could be a useful tool for communicating medical discharge instructions to populations with Limited English Proficiency (LEP). It is divided into three parts. First, it provides an overview of the biggest struggles LEP patients encounter in healthcare, which often occur around discharge instructions and medication changes. Second, the paper explores what graphic medicine is and how it has been used in healthcare. The last part of this paper consists of original graphic medicine artwork that addresses key issues for LEP populations during discharge with the goal of offering a …

Liposomes As Imaging Agents Of Inflammation And Oxidative Stress In Bone Implants, Delia Danila, Patricia S Pardo, R Devesh Kumar Misra, Aladin M Boriek

Faculty, Staff and Students Publications

Liposomes are tiny, spherical vesicles made from cholesterol and natural phospholipids that are promising imaging agents for detecting medical complications. They can carry fluorescent markers or other imaging agents, making them effective for medical imaging. Furthermore, liposomes can target specific cells involved in inflammation, such as macrophages, and accumulate at inflammation sites when injected. Additionally, liposomes can be designed to respond to oxidative stress, which is often associated with bone implant complications. By detecting areas of stress, liposomes provide valuable information about implant health. However, challenges such as rapid clearance from the body, precise targeting, immune reactions, and high production …

The Use Of Person-Centered Language In Scientific Research Articles Focused On Psychosis, Zach Monahan, Tanner Stone, Vinay Swami, Kelly Dunn, Micah Hartwell

Journal of Patient-Centered Research and Reviews

Purpose: Societal stigma of psychosis leads to delayed treatment for individuals experiencing early symptoms, for fear of being labeled “crazy” or “psychotic.” Delayed treatment can worsen the prognosis of individuals with psychosis. Proper adherence to person-centered language (PCL) guidelines can curb the widely held stigmatized preconceptions about psychotic conditions.

Methods: Our meta-epidemiological analysis began with a systematic search of literature in PubMed discussing psychosis from 2020-2022. From the 14,522 results, we randomly selected 500 articles in journals with at least 20 articles on psychosis (n = 9,775), of which 241 articles met the inclusion criteria. These papers were screened for …

Glucagon-Like Peptide-1 Therapy And Substance Use Disorders, Rachel J. Brunsell

Nursing Capstones

Background: Treatment options for SUDs fail to address the neurobiological underpinnings of addiction. Recent studies suggest that GLP-1s, including semaglutide, liraglutide, and exenatide, offer therapeutic benefits by reducing cravings, improving treatment adherence, and decreasing relapse rates across a range of SUDs, including alcohol, cannabis, cocaine, nicotine, and opioid use disorders.

Purpose: The purpose of this article is to explore studies that highlight the potential benefits of GLP-1 receptor agonists in reducing substance cravings, improving treatment adherence, and decreasing relapse rates for patients with various SUDs.

Methods: A comprehensive review of recent studies examining the effects of GLP-1 receptor agonists, including …

Molecular Changes, Histopathology, And Ultrasonic Vocalization Acoustic Profiles Of Systemically Dehydrated Rats, Brooke Rodgers, Naila Cannes Do Nascimento, Abigail Cox, Taylor W. Bailey, M. Preeti Sivasankar, Allison J. Schaser

Department of Speech, Language, and Hearing Sciences Faculty Publications

Systemic hydration is known to promote optimal functioning of bodily systems—including the vocal folds. The impact of systemic dehydration on the biology of the vocal folds and the downstream effects of dehydration on voice output are not well understood. An in vivo rat model of systemic dehydration was employed to investigate vocal fold gene expression, histological changes, and acoustic changes in vocalization. Ultrasonic vocalizations (USVs) were recorded every day for 5 days (baseline), in male and female Long-Evans rats (N = 36, ages: 3–4 months) using an anticipatory reward paradigm. Next, rats were dehydrated (N = 18) using a published …

The Impact Of Marijuana Edibles On Fetal Development In Pregnant Adolescents And Young Mothers, Rachel Doyle

Honors Theses

With the growing prevalence of marijuana use for both recreational and medicinal purposes, this study explores the impact of edible cannabis consumption on fetal development in pregnant adolescents and young mothers. While most existing research focuses on smoked cannabis in adult populations, this review highlights a significant gap regarding the unique risks of edibles among younger, vulnerable users who may perceive them as safer. Through a comprehensive literature review, the study examines the physiological effects of THC in edible form, as well as the social, economic, and healthcare factors influencing its use. Key areas of focus include maternal health, placental …

Quantifying The Functional Impact Of Chronic Patellofemoral Pain And Its Relationship To Perceived Duty-Related Medical Readiness Among Active Duty Service Members, Emma H. Beisheim-Ryan, Sara R. Gorczynski, Ryan W. Smith, Shawn Farrokhi

Physical Therapy Faculty Articles and Research

Introduction

Chronic patellofemoral pain (PFP) is a heterogeneous pain condition that may significantly burden active duty service members, whose rigorous physical training demands include activities such as running and heavy load carriage. While chronic PFP is often defined by its pathoanatomical characteristics, evidence from other pain conditions (e.g., chronic low back pain) suggests classifying pain by its functional impact on work, social, and self-care activities may better inform personalized treatment approaches. As this approach has not been previously undertaken in chronic PFP or younger populations with chronic pain, this study aimed to characterize the global impact of PFP on day-to-day …

Phytochemistry, Antioxidant And Cytotoxic Activities Of Hibiscus (Hibiscus Rosa-Sinensis) Extract On Mcf-7 Breast Cancer Cells, Ade Arsianti, Isma Zahira Suhaima, Steven Gill, Ajeng Megawati Fajrin, Lince Dameria Nadapdap, Norma Nur Azizah, Hiroki Tanimoto, Shun Hirota

Indonesian Journal of Medical Chemistry and Bioinformatics

Background: Breast cancer is the most common type of cancer in women with a very high mortality rate. This cancer is caused by uncontrolled growth of breast cells. Treatments for this malignancy are surgery, chemotherapy, and radiotherapy, however those methods can cause adverse effects and quite expensive. Complementary and alternative medicines (CAMs) are also used to support those main treatments, one of them is herbal medicine. Hibiscus rosa-sinensis is known to have various phytochemical components with antioxidant, antibacterial, anticancer, and analgesic activities. This study is aimed to determine the phytochemical composition, antioxidant activity and cytotoxicity of Hibiscus rosa-sinensis extract towards …

Tobacco Smoking Functional Networks: A Whole-Brain Connectome Analysis In 24 539 Individuals, Yezhi Pan, Chuan Bi, Zhenyao Ye, Hwiyoung Lee, Jiaao Yu, Luba Yammine, Tianzhou Ma, Peter Kochunov, L Elliot Hong, Shuo Chen

Faculty, Staff and Student Publications

Introduction: Nicotine addiction, a multifaceted neuropsychiatric disorder, profoundly impacts brain functions through interactions with neural pathways. Despite its significance, the impact of tobacco smoking on the whole-brain functional connectome remains largely unexplored.

Aims and methods: We conducted a whole-brain analysis on 24 539 adults aged 40 and above from the United Kingdom Biobank cohort. Subjects were categorized into individuals who use nicotine and those who do not use nicotine based on current and chronic tobacco smoking information. Functional connectivity was assessed using resting-state functional magnetic resonance imaging. We employed a network analysis method to assess the systematic effects of tobacco …

Can The Discovery Of High-Impact Diagnostics Be Improved By Matching The Sampling Rate Of Clinical Diagnostics To The Frequency Domain Of Diagnostic Information?, Steven W Millward, Peng Wei, David Piwnica-Worms, Seth T Gammon

Faculty, Staff and Student Publications

Over the past 30 years, academic and industrial research investigators have developed molecular reporters to visualize cell death in complex biological systems. In parallel, clinical researchers, chemists, biochemists, and molecular biologists have endeavored to translate these molecular tools into clinical imaging agents. Despite these efforts, there are no clinically approved imaging methodologies with which to image cell death consistently and quantitatively. One reason may reside in the intrinsic mismatch between the sampling frequency of translational molecular imaging and the biochemical kinetics that define cell death. Beyond cell death imaging, many active research programs are now attempting to create translational diagnostic …

The Combined Effect Of High-Intensity Interval Training And Time-Restricted Feeding On The Akt-Igf-1-Mtor Signaling Pathway In The Muscle Tissue Of Type 2 Diabetic Rats, Motahareh Mohebinejad, Fatemeh Kazeminasab, Mahtab Ghanbari Rad, Reza Bagheri, Mazdak Razi, Darryn Willoughby, Fred Dutheil

Faculty, Staff and Students Publications

Background/Objectives: High-intensity interval training (HIIT) and time-restricted feeding (TRF) have shown potential in enhancing glucose metabolism, increasing insulin sensitivity, and promoting muscle health. This study investigates the combined effects of HIIT and TRF on the AKT-IGF-1-mTOR signaling pathway in the muscle tissue of type 2 diabetic (T2D) rats.

Methods: 42 male Wistar rats (4-5 weeks of age) were included in the study. The animals were randomly divided into two groups: 1. Standard diet (SD) non-diabetic (n = 7) and 2. High-fat diet (HFD n = 35) for 4 weeks. T2D was induced by intraperitoneal injection (IP) of streptozotocin (STZ) …

Samd9 Senses Cytosolic Double-Stranded Nucleic Acids In Epithelial And Mesenchymal Cells To Induce Antiviral Immunity, Gaopeng Hou, Wandy Beatty, Juhee Son, Yinxing Zhu, Qingyu Sheng, Wanyi Huang, Dian Li, Constin Liu, Chen Shen, L David Sibley, Siyuan Ding, Et Al.

2020-Current year OA Pubs

Sensing of cytosolic, double-stranded (ds) DNA or dsRNA molecules derived from microbial or endogenous sources triggers cell-intrinsic innate immunity, but sensors recognizing both cytosolic dsDNA and dsRNA are sparsely reported. Here we find that full-length human SAMD9 protein directly binds to synthetic or viral dsDNA or dsRNA. Overexpression of SAMD9 from various vertebrate species leads to robust production of interferons and pro-inflammatory cytokines. By contrast, loss of endogenous SAMD9 impairs the interferon responses to cytosolic dsDNA and dsRNA stimulation in multiple cell types and enhances the infectivity of pathogenic dsDNA and dsRNA viruses. Mice lacking Samd9l, the human SAMD9 homolog, …

Disuse-Driven Plasticity In The Human Thalamus And Putamen, Roselyne J Chauvin, Dillan J Newbold, Ashley N Nielsen, Ryland L Miller, Samuel R Krimmel, Athanasia Metoki, Anxu Wang, Andrew N Van, David F Montez, Scott Marek, Vahdeta Suljic, Noah J Baden, Nadeshka Ramirez-Perez, Kristen M Scheidter, Julia S Monk, Forrest I Whiting, Babatunde Adeyemo, Jarod L Roland, Abraham Z Snyder, Benjamin P Kay, Marcus E Raichle, Timothy O Laumann, Evan M Gordon, Nico U F Dosenbach

2020-Current year OA Pubs

Subcortical plasticity has mainly been studied using invasive electrophysiology in animals. Here, we leverage precision functional mapping (PFM) to study motor plasticity in the human subcortex during 2 weeks of upper-extremity immobilization with daily resting-state and motor task fMRI. We found previously that, in the cortex, limb disuse drastically impacts disused primary motor cortex functional connectivity (FC) and is associated with spontaneous fMRI pulses. It remains unknown whether disuse-driven plasticity pulses and FC changes are cortex specific or whether they could also affect movement-critical nodes in the thalamus and striatum. Tailored analysis methods now show spontaneous disuse pulses and FC …

New Insights Into Epileptic Spasm Generation And Treatment From The Ttx Animal Model, John W Swann, Carlos J Ballester-Rosado, Chih-Hong Lee

Duncan NRI Faculty and Staff Publications

Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much-needed mechanistic information for therapy development. Our laboratory has focused on the TTX model and in this paper, we review some of our findings. To induce spasms, tetrodotoxin (TTX) is infused into the neocortex of infant rats. TTX produces a lesion at its infusion site and thus mimics IESS resulting from acquired structural brain abnormalities. Subsequent electrophysiological studies showed that the epileptic spasms originate from neocortical layer V …

The Havcr1-Centric Host Factor Network Drives Zika Virus Vertical Transmission, Wenzhe Yu, Jun Tao, Hongmin Cao, Wanshan Zheng, Beiang Zhang, Yue Zhang, Peiqun Xu, Yiwei Zhang, Xuan Liu, Yinan Wang, Han Cai, Gang Liu, Fan Liu, Haibin Wang, Haiyan Zhao, Indira U Mysorekar, Xiaoqian Hu, Bin Cao

Center on Aging Staff Publications

Zika virus (ZIKV) vertical transmission results in devastating congenital malformations and pregnancy complications; however, the specific receptor and host factors facilitating ZIKV maternal-fetal transmission remain elusive. Here, we employ a genome-wide CRISPR screening and identify multiple placenta-intrinsic factors modulating ZIKV infection. Our study unveils that hepatitis A virus cellular receptor 1 (HAVCR1) serves as a primary receptor governing ZIKV entry in placental trophoblasts. The GATA3-HAVCR1 axis regulates heterogeneous cell tropism in the placenta. Notably, placenta-specific Havcr1 deletion in mice significantly impairs ZIKV transplacental transmission and associated adverse pregnancy outcomes. Mechanistically, the immunoglobulin variable-like domain of HAVCR1 binds to ZIKV via …

Unveiling The Potential Of Urolithin A In Cancer Therapy: Mechanistic Insights To Future Perspectives Of Nanomedicine, Vinita Karumuru, Anupam Dhasmana, Narsimha Mamidi, Subhash Chauhan, Murali Yallapu

School of Medicine Publications

Cancer remains a leading global health challenge, with high mortality rates persisting despite significant advancements in therapeutic interventions. Major obstacles, including systemic toxicity, therapy resistance, metastasis, and relapses, emphasize the urgent need for safer, more effective, and readily accessible treatment strategies. Among emerging alternatives, natural bioactive compounds have gained considerable attention because of their diverse therapeutic potential and lower toxicity profiles. Urolithin A (UA), a metabolite derived from ellagic acid through gut microbiota metabolism, has emerged as a compelling anticancer agent. UA has multiple mechanisms of action, including the regulation of autophagy, enhancement of mitochondrial function, and inhibition of tumor …

Is Love A “Pathological Condition Of The Soul”? Joyce Carol Oates's Beasts And Rape: A Love Story, Nicolas P. Boileau

Bearing Witness: Joyce Carol Oates Studies

This paper seeks to address the question of Oates’s relation to feminist and gender theories by looking at two novellas published consecutively, Beasts and Rape: A Love Story in the beginning of the 2000s. The short texts share a common storyline based on rape, which is far from uncommon in Oates’s fiction. However, I argue that there is something very specific in these two novellas in the way Oates chooses to handle the testimony of the rape, both overtly and covertly, both in graphic details and in repressed forms of expression, giving way to a reflection on women’s vulnerable position …

Guideline Development And Implementation For Non-Intubated Video-Assisted Thoracoscopic Surgery, Lauren Moad

Doctor of Nursing Practice Scholarly Projects

Since the 1990s, video-assisted thoracoscopic surgery (VATS) has become the standard for many thoracic operations, providing a minimally invasive approach. Traditional VATS management with general anesthesia (GA), muscle relaxation, and one-lung ventilation (OLV) poses risks of postoperative pulmonary complications (PPCs) that can lead to a prolonged length of hospital stay (LOS). Recently, non-intubated VATS (NI-VATS) has become popular due to fewer anesthesia-related complications and faster recovery, especially for patients with compromised respiratory function who may not tolerate GA or intubation. NI-VATS combines regional anesthesia with spontaneous non-invasive ventilation mechanisms, avoiding GA, intubation, and OLV complications. Studies show NI-VATS leads to …

Utilization Of Zinc As A Supplemental Treatment To Prostate Cancer, Cony Cs Chow, Vishal Ahuja, Luis Mangiafico

Department of Nutrition Student Projects

Prostate cancer remains as a significant contributor to mortality among men worldwide, and despite advancements in treatment, there is still a need for adjunct therapies that could assist in mitigating the progression of this disease. Zinc is an essential trace element which plays a crucial role in the function of the prostate and has shown signs of influencing the development of prostate cancer. This prospective study will aim to evaluate the effects of zinc supplementation on the progression of prostate cancer through a controlled experimental design. Participants will include patients who are diagnosed with prostate cancer (stages 1-3) and will …

Animal-Assisted Therapy With Children In Hospitals And Schools: A Systematized Review, Tantine Kendig

LSU Master's Theses

It has been demonstrated that animals can offer humans significant health benefits. Animal-assisted therapy (AAT) is a growing form of therapy used in various settings to enhance the health of children, encompassing both physical and mental wellness. The challenges of hospitalization and the school environment have been shown to pose different challenges for children, such as an increase in anxiety, stress, depression, and others that have the potential to affect their mental, physical, emotional, and social well-being. This study aimed to assess the effectiveness of animal-assisted therapy, specifically dog-assisted therapy, on children in hospital and school settings by conducting a …

Exploring The Lived Experience Of Growing Up With A Neurodivergent Sibling, Madison Hall, Jazminne Orozco Arteaga

Spring 2025 OTD Capstone Symposium

Neurotypical siblings of neurodivergent children often experience unique roles, responsibilities, and emotional challenges within their family systems, yet their needs are frequently overlooked in service delivery models. This mixed methods study explored the lived experiences of individuals who grew up with neurodivergent siblings, focusing on the occupations, routines, and play experiences that shaped their development. Four themes emerged through thematic analysis of survey responses and semi-structured interviews: (1) play as a reconstructed experience, (2) role imbalance in daily life, (3) environmental influences on occupational engagement, and (4) navigating emotional demands. Findings highlight the need for occupational therapists to include neurotypical …

Ua12/2/1 College Heights Herald, Vol. 100, No. 3, Wku Student Affairs

WKU Administration Documents

Magazine edition of the College Heights Herald for the period February 17 - April 20, 2025.

• Wilborn, Price. You Matter & You Are Not Alone
• Smith, Kane. Peggy Crowe Reflects on Counseling Center in Face of Staff Shortages
• Stafford, Hallie. Help with Horses – New Beginnings Therapeutic Horse Riding
• Hawkins, Kaylee. How a WKU Professor Helps Improve Student Mental Health – Jay Gabbard, National Alliance on Mental Illness Recovery Support Group
• McMahon, Jake. More Than a Coach – Brent Chumbley, Track & Field
• Simpson, Libby. WKU’s American Foundation for Suicide Prevention Brings Mental Health Into the Light
• Hardesty, Emma. Trans …

The Impact Of Sensory Sensitivity On Nutritional Outcomes In Children With Neurodevelopmental Disorders, Rachel M. Qualley

Theses and Dissertations

Background/Objective: Children with neurodevelopmental disorders (NDDs) are at increased risk of malnutrition due to restrictive dietary patterns and behavioral difficulties at mealtimes. Research suggests that heightened sensory sensitivity, a characteristic accompanying several of these disorders, may be a contributing factor. However, the effects of sensory sensitivity on nutritional outcomes across distinct NDDs have not been fully explored. This review aims to examine the relationship between sensory sensitivity and nutritional status, food preferences, and eating behaviors in children with NDDs, specifically investigating how atypical sensory processing might influence dietary intake.

Methods: A literature search was conducted using Google Scholar, PubMed, …

Structural Basis For Polθ-Helicase Dna Binding And Microhomology-Mediated End-Joining, Fumiaki Ito, Ziyuan Li, Leonid Minakhin, Htet A. Khant, Richard T. Pomerantz, Xiaojiang S. Chen

Department of Biochemistry and Molecular Biology Faculty Papers

DNA double-strand breaks (DSBs) present a critical threat to genomic integrity, often precipitating genomic instability and oncogenesis. Repair of DSBs predominantly occurs through homologous recombination (HR) and non-homologous end joining (NHEJ). In HR-deficient cells, DNA polymerase theta (Polθ) becomes critical for DSB repair via microhomology-mediated end joining (MMEJ), also termed theta-mediated end joining (TMEJ). Thus, Polθ is synthetically lethal with BRCA1/2 and other HR factors, underscoring its potential as a therapeutic target in HR-deficient cancers. However, the molecular mechanisms governing Polθ-mediated MMEJ remain poorly understood. Here we present a series of cryo-electron microscopy structures of the Polθ helicase domain (Polθ-hel) …

Tips For Quality Publishing; Lessons From The Neuroscience Editorial Team, Francesca Cirulli, Rachael Dangarembezi, Victor De Lafuente, Anthony J Hannan, Amanda C Kentner, Tatsuya Mima, Laurel Morris, Sarah J Spencer, Long-Jun Wu, Chen Zhang

The Brown Foundation: Institute of Molecular Medicine

In pursuit of excellence in scholarly publishing, the Neuroscience editorial team shares valuable insights that are essential for authors, reviewers, and the broader scientific community. Firstly, we emphasize that impactful research is built on rigorous study design and execution. Beyond fundamental methodological safeguards such as randomization and blinded analysis, we highlight the importance of thoughtfully selecting study models, with deliberate attention to biological variables like sex and gender, as well as appropriate nomenclature. Secondly, as technological innovations reshape research landscapes, we advocate for combining methodological rigor with suitable analytical tools to ensure robust data collection and transparent reporting. Thirdly, for …

The Renal Social Workers' Perspective: Attitude, Behaviors, And Barriers To Sexual Health Inclusion, Sapphira L. Blount Murray

Doctoral Dissertations and Projects

Sexual health, an important factor of perceived wellness and quality of life, is adversely impacted by renal disease and treatment. The social worker is uniquely positioned on the renal clinical care team to address sexual health. There is a dearth of literature on renal care and sexual health, and no national study on whether or how sexual health is being addressed in renal care planning by the social worker. This qualitative case study was aimed at exploring the attitudes, behaviors, and perceived barriers based on the lived experiences of renal social workers in incorporating sexual health assessments into routine renal …

The Influence Of Military Mindset In Canine Selection For The Mitigation Of Ptsd Symptomology Within A Tennessee Veteran Population: A Phenomenological Study, Rachael Michelle Bandlow Thompson

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to explore the influence of military mindset on personal canine selection through the lived experiences of Tennessee military veterans to enhance military cultural competency and aid in development of complimentary and integrative approaches to veteran mental health. Insufficient research exists into understanding the specific needs of reintegrating veterans and into the benefits of canine-assisted therapies. The theories which guided this study were Albert Bandura’s Social Cognitive Theory of Learning and Abraham Maslow’s Theory of Motivation. This qualitative study was further guided by axiological philosophical assumptions. Fifteen participants were recruited via email and selected …

Enriched Pathways In Gut Microbiome Predict Response To Immune Checkpoint Inhibitor Treatment Across Demographic Regions And Various Cancer Types, Xunhui Cai, Jennifer Y Cho, Lijun Chen, Yufeng Liu, Fenghu Ji, Katia Salgado, Siyi Ge, Dehua Yang, Hui Yu, Jianbo Shao, P Andrew Futreal, Boris Sepesi, Don Gibbons, Yaobing Chen, Guoping Wang, Chao Cheng, Meng Wu, Jianjun Zhang, Ansel Hsiao, Tian Xia

Faculty, Staff and Student Publications

Understanding the effect of gut microbiota function on immune checkpoint inhibitor (ICI) responses is urgently needed. Here, we integrated 821 fecal metagenomes from 12 datasets to identify differentially abundant genes and construct random forest models to predict ICI response. Gene markers demonstrated excellent predictive performance, with an average area under the curve (AUC) of 0.810. Pathway analyses revealed that quorum sensing (QS), ABC transporters, flagellar assembly, and amino acid biosynthesis pathways were enriched between responders (R) and non-responders (NRs) across 12 datasets. Furthermore,

Rnase1-Driven Alk-Activation Is An Oncogenic Driver And Therapeutic Target In Non-Small Cell Lung Cancer, Zhengyu Zha, Chunxiao Liu, Meisi Yan, Cong Chen, Cheng Yu, Yaohui Chen, Chenhao Zhou, Lu Li, Yi-Chuan Li, Hiro Yamaguchi, Leiguang Ye, Tong Liu, Ying-Nai Wang, Heng-Huan Lee, Wen-Hao Yang, Li-Chuan Chan, Baozhen Ke, Jennifer L Hsu, Lieming Ding, Dong Ji, Peng Pan, Yiran Meng, Yue Pu, Lunxu Liu, Mien-Chie Hung

Faculty, Staff and Student Publications

Targeted therapy has achieved significant success in the treatment of non-small cell lung cancer (NSCLC), particularly in patients harboring common oncogenic driver mutations such as EGFR, KRAS, and ALK rearrangement. However, ~35-50% of NSCLC patients without tyrosine kinase mutation or rearrangement (non-mutated) cannot benefit from these targeted treatments, highlighting the urgent need for novel therapeutic strategies for this patient population. In this study, we report a non-canonical role of human secretory ribonuclease 1 (RNase1), which binds to and activates wild-type ALK in lung cancer cells, thereby triggering its downstream signaling pathway. RNase1-driven ALK-activation (RDAA) cells exhibit enhanced cell proliferation, migration, …

Molecular Mechanism Establishing The Off Pathway In Vision, Florentina Soto, Chin-I Lin, Andrew Jo, Ssu-Yu Chou, Ellen G Harding, Philip A Ruzycki, Gail K Seabold, Ronald S Petralia, Daniel Kerschensteiner

2020-Current year OA Pubs

Parallel ON and OFF (positive- and negative-contrast) pathways fundamental to vision arise at the complex synapse of cone photoreceptors. Cone pedicles form spatially segregated functionally opposite connections with ON and OFF bipolar cells. Here, we discover that mammalian cones express LRFN2, a cell-adhesion molecule, which localizes to the pedicle base. LRFN2 stabilizes basal contacts between cone pedicles and OFF bipolar cell dendrites to guide pathway-specific partner choices, encompassing multiple cell types. In addition, LRFN2 trans-synaptically organizes glutamate receptor clusters, determining the contrast preferences of the OFF pathway. ON and OFF pathways converge in the inner retina to regulate bipolar cell …