Digital Commons Network^™

Levofloxacin-Ketoprofen Multicomponent Salt Development As A Strategy To Improve The Antibiotic Potency And Anti-Inflammatory Performance, Ilma Nugrahani, Nadhira Dzaky Naushafira, Nova Suliska, Marlia Singgih Wibowo, Hana Fauziah

Makara Journal of Science

Levofloxacin is a fluoroquinolone antibiotic with higher solubility than those from previous generations, but it is light-sensitive. Antibiotics, including levofloxacin, are generally prescribed in combination with nonsteroidal anti-inflamma-tory drugs (NSAIDs) to treat inflammatory infections. Furthermore, NSAIDs have poor water solubility, which can be improved by forming salts or multicomponent systems. This study aimed to develop a multicomponent system from levofloxacin with ketoprofen, an NSAID, and to evaluate its physicochemical characteristics; antibiotic potency; in vivo anti-inflammatory activity; absorption, distribution, metabolism, and excretion (ADME); and in silico toxicity risk. First, a phase diagram was created to predict the interaction type in the …

Bambara Groundnut (Vigna Subterranea L.) Supplementation Ameliorates The Histological Structure Of Skeletal Muscle In Protein-Deficient Mice, Raquellynda Fadilla Syafanisa, Rimonta Febby Gunanegara, Sunarti Sunarti, Siti Aeniah, Ardaning Nuriliani

Makara Journal of Science

Protein deficiency may cause histological alterations and pathological effects in skeletal muscle, leading to reduced mus-cle size and functional degeneration. Bambara groundnuts contain essential amino acids that have the potential to meet the body’s protein requirements. Therefore, this study aimed to investigate the effect of bambara groundnut supplemen-tation on skeletal muscle in protein-deficient mice. Twenty-five female mice were divided into five groups (control, pro-tein deficiency, and protein deficiency with 100, 200, and 300 g of bambara groundnut supplementation/kg of feed). The treatment was administered for 2 months. At the end of the experiment, the left gastrocnemius muscles of the mice …

Network Pharmacology Of A Decaffeinated Green Coffee–Turmeric Combination: Potential Therapeutic Activity Against Hypertension And Diabetes Mellitus, Feri Eko Hermanto, Mohammad Saifur Rohman, Victor Alvianoes Guterez Hose, Mifetika Lukitasari, Dwi Adi Nugroho, Nashi Widodo, Inggita Kusumastuty

Makara Journal of Science

Decaffeinated green coffee and turmeric are recognized for their protective effects against hypertension (HTN) and diabetes mellitus (DM). Combining them into a functional drink, green coffee and turmeric (GCT), offers potential health benefits for managing these conditions. This study explored the bioactivity of GCT in HTN and DM through network biology, identifying intersecting protein targets and their roles in inflammation and glucose metabolism. Key proteins identified were AKT1, CCL2, CXCL8, IL-1β, and IL18. Molecular docking revealed that GCT compounds, particularly Cafestol, Chlorogenic Acid, Kahweol, Curcumin, and Desmethoxycurcumin, interacted strongly with AKT1 at its allosteric site, potentially inhibiting its activity. However, …

Nuclear Neuroimaging Approaches To Traumatic Brain Injury: Current Insights And Future Directions, Shivani Daksh, Anupriya Adhikari, Nikhil Kumar, Garima Mann, Anupama Datta

Makara Journal of Science

The aftermath of a traumatic brain injury is characterized by a state of disruption, progressing into secondary injury and culminating in a complex network of interconnected pathophysiological disturbances.  The potential risk of developing neurological disorders after TBI highlights the pressing need to enhance our understanding and develop therapeutic in-terventions to alleviate its devastating consequences. Traumatic brain injury can lead to a range of problems, including pain, swelling, axonal degeneration, and chronic amnestic and non-amnestic cognitive impairments. The first and essential step in the management of TBI is to identify and characterize the clinical symptoms. This systematic review outlines the established …

Presumptive Feline Infectious Peritonitis-Associated Uveitis With Posterior Segment Mass-Like Lesions On Ultrasonography, Hyun-Wook Kim, Danbee Kwon, Joon Young Kim

The Thai Journal of Veterinary Medicine

5-year-old neutered male domestic shorthair cat was presented with unilateral anterior uveitis and ocular pain in the left eye without systemic signs. Ophthalmic examination revealed a superficial corneal ulcer, keratic precipitates, and aqueous flare. Ocular ultrasonography identified ciliary body thickening and a nodular mass-like lesion posterior to the ciliary body. Despite systemic corticosteroid treatment after corneal ulcer healing, no clinical improvement was observed. Computed tomography revealed contrast-enhancing thickening of the ciliary body and uveoscleral region. Enucleation and histopathology demonstrated pyogranulomatous inflammation without evidence of neoplasia or detectable infectious organisms. Immunohistochemistry for feline coronavirus antigen was not performed at that time. …

Expression Of Follicle Stimulating And Luteinizing Hormone Receptors In Porcine Testes After Timing The First Vaccination For Immunocastration, Sayamon Srisuwatanasagul, Rungrueang Yodsheewan, Amornthep Archawakulathep, Suvaluk Seesupa, Kongkiat Srisuwatanasagul, Atthaporn Roongsitthichai, Siriluck Juntautsa

The Thai Journal of Veterinary Medicine

This study aimed to examine the expression of follicle stimulating hormone receptor (FSHR) and luteinizing hormone receptor (LHR) in the testes of male fattening pigs based on the timing of the first immunocastration dose. A total of 24 male pigs were randomly assigned to 3 groups: C (n=8) consisted of only intact pigs, T1 (n=8) contained those immunocastrated at 15 and 19 weeks of age, and T2 (n=8) was composed of those immunocastrated at 9 and 19 weeks of age. The expression of FSHR and LHR was evaluated using H-score from immunohistochemistry and protein band intensity from Western blotting. Immunohistochemistry …

Journal Ida 2023 102 3

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.

Indian Standard For Safe Handling Of Biotherapeutic Products Used In Homoeopathy: Guidelines, Kumar Vivekanand, Indra Gaurav Saxena, Divya Taneja, Shailendra K. Saxena, Shrishti Dixit, Raj Kumar Manchanda

Indian Journal of Research in Homoeopathy

Biotherapeutic products used in Homoeopathy are derived from biological sources of human, animal, microbial and other origins and include pathological and non-pathological preparations such as nosodes and sarcodes. Owing to the biological nature of these materials, their safe handling, preparation, storage, testing and documentation require systematic controls to protect personnel, the public and the environment. The Indian Standard `IS 19901:2026, Safe Handling of Biotherapeutic Products Used in Homoeopathy — Guidelines', provides a comprehensive framework for risk assessment, biosafety classification, containment, determination of first safe dilution (FSD), safety and efficacy evaluation, quality assurance, formulation, dispensing and documentation. The standard also establishes …

Raman Spectroscopy Characterisation Of 5c Potency Of Homoeopathic Drugs Nux Vomica, Thuja Occidentalis And Nitricum Acidum, Alfonso Tramontana, Giuseppe Acri, Lucia Denaro, Massimo Mattozzi, Maria Antonietta D'Avanzo, Barbara Testagrossa

Indian Journal of Research in Homoeopathy

Background: The physicochemical characterisation of homoeopathic medicines remains a challenge. Raman spectroscopy is a promising tool for identifying structural modifications in the solvent matrix and specific vibrational ``fingerprints'' induced by the potentisation process. Objective: This study aimed to characterise three remedies (Nux vomica, Thuja occidentalis, and Nitricum acidum - 5C potencies) using Raman spectroscopy to identify specific vibrational markers and evaluate the technique's ability to differentiate between different preparations within a complex matrix. Materials and methods: The drugs were analysed as crushed granules (solid state) and after dissolution in betamethasone disodium phosphate (liquid state). Raman spectroscopy was …

Immunomodulatory Activity Of Bryonia Alba 6c And 30c In Sheep Red Blood Cell-Immunised Mice: Insights From Humoral And Delayed-Type Hypersensitivity Responses, Abanti Goswami, Narasimha Kumar Gv, Vara Prasad Saka, Suneel Prajapati, Bibaswan Biswas, Pankaj Gupta

Indian Journal of Research in Homoeopathy

Background: Malnutrition and infectious diseases compromise immune responses, increasing vulnerability to infections. The introduction of plant-derived immunomodulators, such as Bryonia alba (Bry. alba), is attracting attention due to their lower side effects compared with chemical drugs. In Homoeopathy, Bry. alba has long been utilised to treat a wide range of illnesses, including viral infections, and is recognised for its immunomodulatory properties. Objectives: To evaluate the immunomodulatory effects of Bry. alba 6C and 30C potencies on humoral and delayed-type hypersensitivity (DTH) in sheep red blood cell (SRBC)-immunised BALB/c mice. Materials and methods: Fifty BALB/c mice were divided into five …

World Homoeopathy Day 2026: Homoeopathy For Sustainable Health, Candy Benny, Sonu Kumar, Divya Taneja, Pankhuri Misra, Renu Mittal, Subhash Kaushik

Indian Journal of Research in Homoeopathy

The World Homoeopathy Day (WHD) 2026 – a two-day interactive forum to commemorate the 271^st birth anniversary of Dr. Samuel Hahnemann, founder of Homoeopathy, was held on 10^th – 11^th April 2026 at Vigyan Bhawan, New Delhi, India. The event was organised by CCRH, NCH, and NIH under the aegis of the Ministry of Ayush. Centered on the theme of ``Homoeopathy for Sustainable Health'', the event emphasised the role of Homoeopathy in promoting and ensuring sustainable health. The event witnessed participation from approximately 1,800 delegates comprising policy makers, practitioners, researchers, academicians, and students. There were a …

Exploring Which Ehr Interventions Improve Heart Failure Hospitalization Outcomes Across 10 Hospitals, Sheraz Qamar, Andres Alvarado, Thomas Buckwalter, Patricia C. Henwood, Dana Jordan, Cara Martino, Jeffrey Riggio, Charlotte Sacksteder, Jared Vanderzell, Alan Kubey

Department of Medicine Faculty Papers

BACKGROUND: Heart failure (HF) remains a major cause of mortality and hospitalization despite advances in guideline-directed medical therapy (GDMT). Electronic health record (EHR)-based clinical decision support tools may improve care delivery, but their impact on outcomes remains ill-defined.

PROJECT RATIONALE: As part of a system-wide HF quality improvement initiative, we evaluated 2 EHR interventions: an evidence-based HF admission order set promoting early diuresis and GDMT optimization, and a templated HF documentation tool (HFNOTE) designed to capture clinical complexity.

PROJECT SUMMARY: We analyzed 4,865 HF hospitalizations across 10 hospitals between December 2024 and June 2025. Overall risk-adjusted mortality index was 0.83 …

Evaluating Electronic Health Record Intervention Efficacy In Enhancing Inpatient Initiation Of Guideline-Directed Medical Therapy, Sheraz Qamar, Trisha Sindhu, Charlotte Pirquet, Benjamin Richter, Charlotte Sacksteder, Tatianna Branch, Jeffrey Riggio, Cara Martino, Patricia C. Henwood, Alan Kubey

Department of Medicine Faculty Papers

BACKGROUND: Heart failure (HF) is a leading cause of hospitalization, morbidity, and mortality. Despite evidence supporting guideline-directed medical therapy (GDMT), prescribing remains suboptimal, particularly at hospital discharge.

PROJECT RATIONALE: Hospitalization provides an opportunity to initiate or optimize GDMT, but workflow barriers and practice variation limit implementation. To address this gap, our system implemented a system-wide HF quality improvement initiative featuring evidence-based order sets and an electronic health record smart phrase ("HFNOTE") to centralize and standardize documentation and encourage GDMT use.

PROJECT SUMMARY: We analyzed 2,859 HF hospitalizations across 10 hospitals between December 1, 2024 and June 30, 2025. Use of …

Ehr-Based Quality Interventions Associated With Differential Gdmt Prescribing In Community Versus Academic Hospitals, Trisha Sindhu, Charlotte Pirquet, Sheraz Qamar, Tanay-Veer Gandhi, Patricia C. Henwood, Cara Martino, Jeffrey Riggio, Jared Vanderzell, Charlotte Sacksteder, Alan Kubey

Department of Medicine Faculty Papers

BACKGROUND: Institutional barriers are associated with suboptimal guideline-directed medical therapy (GDMT) prescribing at heart failure discharge.

PROJECT RATIONALE: Practice variations between academic medical centers (defined as "teaching" hospitals with residents) and community hospitals are poorly understood. Evaluating how diverse settings respond to quality improvement strategies is vital.

PROJECT SUMMARY: A multicenter study across 10 electronic health record-unified hospitals evaluated 3,535 heart failure encounters. Phase 1 implemented educational work groups and financial incentives; phase 2 introduced clinical decision support systems. Community hospitals responded significantly to phase 1 education/incentives, with mean discharge of GDMT agents rising from 2.19 to 2.44 (P = …

Integrating Public Health Into Communication Sciences And Disorders Curriculum, Whitney D. Perkins, Yalanda M. Barner, Jennifer Wiles, Brandi Newkirk-Turner

Teaching and Learning in Communication Sciences & Disorders

The field of Communication Sciences and Disorders (CSD) is increasingly integrating public health into its practice and research. This is because less than 10% of speech-language pathology and audiology graduate programs are housed within Colleges or Schools of Public Health (PH), reducing the likelihood that students in CSD have the opportunity for coursework and co-curricular activities that integrate PH and CSD. In this paper, we discuss the holistic approach we used to integrate PH into a CSD program at a Historically Black University. The approach was guided by PH and CSD accreditation standards and involved a didactic course, CSD courses …

The Implementation Of Sel-Based Interactive E-Modules To Enhance Mental Health Literacy, Muhammad Arif Budiman Sucipto, Mulyani Mulyani

Jurnal Kajian Bimbingan dan Konseling

The mental health crisis among Generation Alpha students is concerning, marked by stagnating life purpose and digital academic pressure. This study aims to examine the effectiveness of an interactive SEL-based E-Module in enhancing students' mental health literacy, offering an innovative solution responsive to the digital era. Employing a Classroom Action Research design integrated with ADDIE. Thirty-two tenth-grade students with low initial literacy scores (mean pre-test = 42.3) participated through purposive sampling. The two-cycle intervention utilized a digital module featuring Private Mode (encrypted emotional journal) and Emergency Button (direct link to counselors). Data were collected through literacy scales, observations, interviews, and …

Plasma Vgf As A Predictive Biomarker For Early Acute Kidney Injury In Critically Ill Elderly Patients: A Combined Clinical And Mendelian Randomization Study, Xianyang Guo, Yu Hao, Rujie Chenn, Benji Wang, Shengwei Jin

Saudi Medical Journal

Objectives: To assess whether VGF nerve growth factor inducible (VGF) can serve as a reliable predictor of acute kidney injury (AKI) among patients requiring intensive care.
Methods: We first conducted a Mendelian randomization (MR) analysis to explore the potential causal link between plasma VGF levels and AKI risk. Subsequently, 128 critically ill individuals admitted to our intensive care unit were prospectively enrolled. Within 24 hours of either hospital admission or clinical decline, both blood and urine specimens were obtained. We measured VGF concentrations in plasma and urine, along with plasma cystatin C (pCysC), plasma and urinary neutrophil gelatinase-associated lipocalin (NGAL), …

Advancing Impact: A National Approach To Knowledge Translation In Saudi Arabia-The Saudi National Institute Of Health Experience, Maha M. Aleid, Manar A. Alharbi, Amal N. Almadouj, Ahmad I. Alrawaji, Lamia A. Alhaqbani, Fars K. Alanazi

Saudi Medical Journal

Objectives: To present a reproducible national model for translating research findings into evidence-based clinical practice guidelines.
Methods: The Saudi National Institute of Health launched the initiative titled ``Transforming the Outcomes of Published Health Research into Medical Guidelines that Enhance Medical Practices to Improve the Quality of Human Health'' on February 3, 2025. The initiative aimed to identify and assess research outcomes published between January 1, 2020, and December 31, 2024 across 6 predefined thematic tracks relevant to the Saudi population. Eligible publications were collected within one month after the submission portal opened. Following closure of portal, all submissions were evaluated …

Efficacy Of A Mouthwash Containing Standardized Centella Asiatica Extract (Eca 233) In Patients With Gingivitis: A Randomized Double-Blind Placebo-Controlled Trial, Alisa Awapark, Wanchai Chongcharoen, Mayuree H. Tantisira, Nattapon Rotpenpian

The Thai Journal of Pharmaceutical Sciences

Background: Gingivitis is the earliest and most reversible stage of periodontal disease, characterized by inflammation of the gingiva caused by the accumulation of plaque. In addition to removing plaque, mouthwash containing antiseptic or anti-inflammatory could be used as an adjunct therapy.
Objectives: The objective of this study is to evaluate the efficacy of a 0.10% standardized Centella asiatica extract (ECa 233) mouthwash compared to 0.12% chlorhexidine and placebo mouthwashes in individuals with gingivitis.
Materials and Methods: A randomized, double-blind, placebo-controlled clinical trial was conducted in 75 patients assigned equally to ECa 233, chlorhexidine, or placebo groups. Participants used the assigned …

Comparative Potency Testing Of Diphtheria Toxoid In Guinea Pigs And Mice For In-House Diphtheria-Tetanus-Pertussis And Diphtheria-Tetanus Vaccines, Wanlop Leeden, Supanee Ummalukacholk, Orawin Mangkhaladul, Eakachai Prompetchara

The Thai Journal of Pharmaceutical Sciences

Background: Diphtheria remains endemic in parts of Thailand and continues to threaten unvaccinated populations. To strengthen vaccine self-sufficiency, the Government Pharmaceutical Organization has developed in-house diphtheria–tetanus–pertussis (DTP) and diphtheria– tetanus (dT) vaccines. Potency testing of diphtheria toxoid is traditionally performed in guinea pigs; however, limitations in animal availability, cost, and logistics have prompted evaluation of alternative models.
Objectives: To compare diphtheria toxoid potency estimates of in-houseproduced DTP and dT vaccines using guinea pigs and mice, followed by a Vero cell-based toxin neutralization assay, and to assess the suitability of mice as an alternative model for potency testing.
Materials and Methods: …

Strengthening The Evidence Base For Pediatric Cardiac Ct: Statistical And Technological Considerations, Faizan Faisal

Journal of the Saudi Heart Association

No abstract provided.

Good Grief: Finding Hope & Achieving Growth In The Face Of Loss, Daniel D. Cowell M.D.

Open Access Books

Grief has profoundly shaped Dr. Dan Cowell's life both professionally and personally. A board-certified psychiatrist, he spent 26 years in the U.S. Public Health Service, including leadership roles across federal health systems, before serving for 15 years as professor and chairman of psychiatry at the Marshall University School of Medicine, and was the Senior Associate Dean for Graduate Medical Education when he retired in 2009.  Throughout his career, he has accompanied individuals and families through some of life's most difficult losses. In his personal life, he has been touched by these losses himself, including the tragic deaths of an infant …

Trauma Work With Horses: Compassion And Connection, Olivia Sagan Prof

The International Journal of Ecopsychology (IJE)

New ways of working with trauma survivors are being sought with the case being made that dominant trauma therapies have relied too heavily on verbal narration and cognitive processing.  Evidence suggests that traumatic experiences are often encoded in sensory, emotional, physiological, and relational systems that may be difficult to access through language alone. This has led to interest in the potential of body-oriented, movement-based, and experiential interventions alongside traditional talk therapies. There are also calls for exploring nature-based therapies as these have shown that engagement with natural environments may help aid the process of healing. Within this context, equine-assisted therapies …

Medetomidine As A Fentanyl Adulterant: Pharmacology, Detection, Clinical Presentation, And Management, Kory S. London, Phil Durney, Brendan Hart, Ashish Thakrar, Dennis Goodstein, Alex J. Krotulski, Daniel Teixeira Da Silva, Joseph D’Orazio, Lara Weinstein, Jeanmarie Perrone, Michael J. Lynch

Division of Internal Medicine Faculty Papers & Presentations

Purpose of Review Medetomidine is a veterinary α2-adrenergic agonist that has been an adulterant of illicitly manufactured opioids since 2022. We review its pharmacology, detection, intoxication, withdrawal, and management, and assess why severe withdrawal has emerged in some regions but not others. Recent Findings Medetomidine has spread through North American drug markets yet evades most toxicology testing. Roughly two hundred times more potent than xylazine, with greater α2 selectivity and imidazoline-1 activity, it causes intoxication resembling other α2 agonists: sedation and bradycardia. The dominant clinical problem is withdrawal: autonomic dysregulation, intractable vomiting, and encephalopathy frequently requiring intensive care. Treatment requires …

Prevalence And Characteristics Of Feline Pleural Effusion In Khon Kaen, Thailand: A 2024–2025 Study, Karn Yongvanit, Naruepon Kampa

The Thai Journal of Veterinary Medicine

Pleural effusion (PE) is a life-threatening condition in cats that can cause severe respiratory compromise. Identification of the underlying etiology is essential for prognosis and treatment planning. This study investigated the prevalence and characteristics of diseases associated with feline pleural effusion in northeastern Thailand. Medical records of cats diagnosed with pleural effusion at the Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Khon Kaen University, Thailand, between January 2024 and January 2025 were retrospectively reviewed. Cases lacking a complete diagnostic workup were excluded. Diagnoses were confirmed using cytology or histopathology for neoplasia, echocardiography for heart disease, polymerase chain reaction (PCR) for …

Neuroimmune Phenotyping As The Next Frontier In Chronic Pain Medicine For Musculoskeletal Back Pain, Samer G. Salman, Rohan A. Phadke, Adithya Nair, Rahul Kumar, Arbaz Momin, Alireza Tavakkoli, James Rizkalla

Department of Neurosurgery Posters

Background: Chronic low back pain encompasses heterogeneous mechanical, neuropathic, nociplastic, and myofascial presentations that may reflect distinct neuroimmune mechanisms. We synthesized evidence linking these phenotypes to measurable biological features and clinically relevant treatment strategies.

Methods: We conducted a structured literature search of MEDLINE, Scopus, Web of Science, and the Cochrane Central Register of Controlled Trials for studies published from January 2005 through January 2025. Systematic reviews, randomized controlled trials, and mechanistic studies addressing neuroinflammation, glial activation, central sensitization, biomarkers, or imaging were organized according to four clinically relevant pain phenotypes and translational readiness.

Results: Neuroimmune findings differed across axial mechanical, …

Acute Liver Injury Likely Induced By Alpha Lipoic Acid Contained In Dietary Supplement, Simona Maksimyan, Jonathan V. Reyes, Kasim Kazbay, Farah K. Gazi

Journal of Community Hospital Internal Medicine Perspectives

The rise in use of herbal and dietary supplements, which are regulated as food rather than as drugs by the Food and Drug Association, poses the risk of unknown and potentially severe side effects. We describe the case of acute liver injury, characterized by significant elevation in AST and ALT, likely induced by the consumption of an over-the-counter supplement containing alpha lipoic acid (ALA). Our patient trusted in a “natural” alternative to Western medicine for management of neuropathy, which was ultimately detrimental to her liver. An immediate and sustained improvement in liver enzyme levels was noted with discontinuation of the …

Impact Of The Widespread Use Of Online Pharmacies On Overall Consumer Safety, Hasanain Am. Abbas, Eswar Kumar Kilari, Shereen M. Mekkey, Hussein Ahmed Jabbar, Mohammed Haider Majid, Haider Majeed Abd Abbas, Hassanein Khaled Hassan

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Online pharmacies improve access to medicines by offering convenient ordering and home delivery, but their growth also creates important risks for medication safety and public health. This review examines the benefits and hazards associated with online medicine supply, including access without a valid prescription, falsified and substandard products, inappropriate medicine use, privacy breaches, and weak cross-border regulatory oversight. The available evidence indicates that illicit online sellers can expose consumers to products of uncertain identity, quality, and dose, while vulnerable users may have limited ability to distinguish legitimate services from unlawful vendors. At the same time, licensed platforms can support continuity …

Preparation And In Vitro Evaluation Of Gastro-Retentive Tablets Of Frusemide Using Gas Generating Excipients As Floating Mechanism, Yousif K. Younis, Ahmed Yousif Fadhel, Nihad Hussein Ahmed

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Frusemide is a loop diuretic used for hypertension, heart failure among many other indications. It has an absorption window in the stomach and it's a class IV drug according to BCS with low bioavailability.
Floating tablets are one of the dosage forms that is best suited for drugs with such absorption window and gas generating excipients can be used to reduce floating lag times even more than traditional floating tablets that relay on density difference alone.
The aim of the study was to investigate the feasibility of floating tablets as a convenient dosage form for oral administration of frusemide aiming …

Current Advances In Cancer Immunotherapy: Mechanisms, Therapeutic Strategies, Challenges, And Future Perspectives, Mohamed E. Abd El-Hack, Mahmoud Moustafa, Mahmoud Kamal, Vincenzo Tufarelli, Muhammad Arif, Laith Aldabbagh

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Cancer immunotherapy has emerged as a transformative therapeutic strategy that harnesses the host immune system to recognize and eliminate malignant cells. This review provides a comprehensive overview of current immunotherapeutic approaches, including immune checkpoint inhibitors (ICIs), monoclonal antibodies (mAbs), cancer vaccines, dendritic cell (DC)-based vaccines, chimeric antigen receptor (CAR)-T cell therapy, and oncolytic virus therapy. The mechanisms of action, therapeutic applications, and clinical benefits of each modality are discussed. Monoclonal antibodies selectively target tumor-associated antigens, whereas ICIs restore antitumor immunity by blocking inhibitory immune checkpoints. Cancer vaccines and DC-based vaccines enhance antigen-specific immune responses, while CAR-T cell therapy employs genetically …