Digital Commons Network^™

Enhancing Public Health Strategies: Addressing The Rsv Burden In Alabama Through Clinical Treatment, Community Prevention, And Surveillance Approaches, Martha K. Findley Roper, Jennifer S. Dawson

Journal of Public Health in the Deep South

Introduction: Respiratory Syncytial Virus (RSV) is a highly contagious pathogen driving morbidity, hospitalizations, and economic burden. This review uses the epidemiological triad and National Wastewater Surveillance System data to assess transmission, viral load spikes in Alabama, and strategies for treatment and prevention.

Methods: A review of literature on supportive care, vaccination, monoclonal antibodies, and emerging nanomedicine was reviewed to evaluate strategies for reducing viral burden and complications.

Results: Trends from December 2024–January 2025 were assessed with National Wastewater Surveillance System data. Primary prevention includes immunization, hygiene, air quality maintenance, and early diagnostics. Tertiary care addresses complications such as secondary …

3d Modeling Of Brain Removal With Cranial Nerve Preservation, Lauren Blank, Sophia Cox, Avery Preston

Student Scholar Symposium

3D Modeling of Brain Removal with Cranial Nerve Preservation Abstract: Visual- spatial skills are essential in learning anatomy as they allow students to mentally visualize and manipulate the three-dimensional structure of the human body. Traditional dissectors like Grant’s Dissector typically provide only 2D images to guide brain removal. These manuals often do not include the occipital wedge approach, which favors cranial nerve preservation during brain dissection. A 3D model that assists students in learning a non-traditional dissection approach through manipulating a brain model will help improve mental rotation skills, especially benefiting those with weaker spatial abilities. In collaboration with Lipscomb …

6ppd-Quinone In Middle Tennessee Waters: Assessing Ecological Impact, Andrew Davis Todd, Raphael Marquise Chandler, Kerolos Gerges Basalos, Denise Lori Loewinger

Student Scholar Symposium

This poster presents the dangers of a toxic chemical used on car tires that is entering aquatic ecosystems and harming fish populations.

Status Of Training In The Use Of Lumen-Apposing Metal Stents For Therapeutic Endoscopic Ultrasound During Advanced Endoscopy Fellowship: A Survey Questionnaire, Yasi Xiao, Maham Hayat, Abdul S. Mohammed, Abdullah Abbasi, Sagar Pathak, Saurabh Chandan, Daryl Ramai, Deepanshu Jain, Muhammad K. Hasan, Mustafa A. Arain, Kambiz K. Kadkhodayan, Natalie Cosgrove, Dennis Yang

Division of Gastroenterology and Hepatology Faculty Papers

Background and Aims The lumen-apposing metal stent (LAMS) has revolutionized endoscopic ultrasound (EUS). However, there is a paucity of data on the optimal approaches to training on the use of LAMSs. This survey study aimed to evaluate the status of training in LAMSs among advanced endoscopy fellowship (AEF) trainees. Methods AEF (academic year 2023-2024) trainees were invited to complete a 15-question survey on LAMS training. The questions included the following domains: demographics, exposure to LAMSs before AEF, number of observed and hands-on participation using LAMSs for EUS-guided pancreatic fluid collection drainage (EUS-PFCD), choledochoduodenostomy (EUS-CD), gallbladder drainage (EUS-GBD), and gastrojejunostomy (EUS-GJ) …

Omics Approaches To Understand Cardiovascular Disease, Zeeshan Ahmed, Goo Jun

Faculty, Staff and Student Publications

Omics approaches have emerged as indispensable tools in unravelling the intricate molecular landscape of cardiovascular disease (CVD) by providing comprehensive insights into the underlying mechanisms driving CVD pathogenesis, progression, and response to therapy. Integrative omics approaches further enhance our understanding by integrating multi-omics data to explain complex molecular networks and identify novel disease pathways. In this collection of BMC Cardiovascular Disorders, we invited submissions on omics approaches to investigate and understand CVD. Successfully achieving the goals of this collection, we were able to publish some interesting and impactful research articles after a rigorous peer review process.

Dual-Task Exercise Protects Healthy Older Adults Against In-Creased Risk For Dementia: A Controlled Trial, Helen Tatiane Santos Pontes, João Bento-Torres, Naina Yuki Vieira Jardim, Victor Oliveira Da Costa, Josilayne Patricia Ramos Carvalho, Cristovam Wanderley Picanço-Diniz, Natáli Valim Oliver Bento-Torres

Baltic Journal of Health and Physical Activity

Background: Functionality in aging is closely linked to the ability to divide attention during multitasking activities, which are essential for activities of daily life. However, coordination between motor and cognitive simultaneous tasks decreases with age, impairing functional ability and restricting older adults' participation and healthy aging. This study aimed to assess the effects of a multimodal dual-task exercise intervention on motor and cognitive dual-task costs and its potential to mitigate age-related declines in healthy older adults. Materials and Methods: A controlled trial was conducted with community-dwelling older adults assigned to either the Dual-Task Exercise group, which participated in a 24-session …

Exploring The Impact Of Inpatient Mental Health Care On Adolescents, Alexandria M. Mckahan

2025 Fall Honors Capstones Projects - Archive

Adolescent psychiatric hospitalizations continue to rise, yet there is limited research on which daily practices inside inpatient units genuinely support engagement and recovery. This project examined how structure, staff tone, and therapeutic programming influence adolescents’ participation and emotional stability within a real inpatient setting. The study focused on three questions: how structured routines affect recovery, what challenges staff face when supporting adolescents with complex needs, and how adolescents’ engagement patterns reflect their perception of care. Using a mixed-methods case study at Mesa Springs Behavioral Health Hospital, I conducted approximately twenty field observations, semi-structured staff interviews, and descriptive engagement tracking across …

Alcohol As Food Or Drug? A Comparative Review Of Islamic And Medical Evidence, M. Diaa El-Din H. Farag, Ahmed A. Rawwash, Emad Hussein Ahmed Fathy, Mohamed F.F Bayomy Et.Al.

Saudi Toxicology Journal

Background: This study conducts a comparative analysis of alcohol classification, health effects, and social consequences within Islamic teachings and modern medical science. Objective: To conduct a comparative analysis of Islamic teachings and modern medical approaches regarding alcohol classification, health effects, and social consequences. Methodology: Using a comparative review following PRISMA guidelines, 50 high-quality sources were selected from an initial 892 records for analysis. Results: The findings demonstrate a convergent classification: both paradigms definitively classify alcohol as a harmful substance rather than a food. Islamic law has prohibited alcohol for over 1400 years on the grounds of it impairs cognitive judgment …

Endocrine Disruptors, Obesity, And Metabolic Syndrome, Tuğba Barlas, Alev Eroğlu Altinova, Meriç Coşkun, Ethem Turgay Ceri̇t

Turkish Journal of Medical Sciences

The global prevalence of obesity and metabolic syndrome (MetS) is rising worldwide, and increasing evidence suggests that chemical exposures—particularly endocrine disruptors (EDs)—represent a significant contributing factor. EDs can act as obesogens, increasing the risk of weight gain and related metabolic conditions, including type 2 diabetes, dyslipidemia, hypertension, and cardiovascular disease. They may also alter the basal metabolic rate, gut microbiota composition, and hormonal regulation of appetite and satiety. EDs are reported to exert their effects mainly through the peroxisome proliferator-activated receptor gamma pathway, which is primarily expressed in adipose tissue and is a key regulator of adipogenesis. Common consumer products …

Endocrine Disruptors And Children's Health, Ersen Karakiliç, Durmuş Doğan, Emre Sedar Saygili

Turkish Journal of Medical Sciences

Endocrine-disrupting chemicals (EDCs) are environmental contaminants that disrupt hormonal regulation by mimicking, inhibiting, or modifying endocrine signaling pathways. EDCs are commonly present in plastics, pesticides, industrial byproducts, and personal care products and pose substantial health risks, particularly to vulnerable groups such as infants and children. Early-life exposure is especially concerning due to the developing detoxification systems, the immaturity of the blood–brain barrier, and the ongoing organ differentiation, making these periods highly susceptible to EDCs’ harmful effects. Moreover, exposure during critical developmental periods, such as sex differentiation and neurodevelopment, can lead to significant long-term developmental impairments that persist into later life.Perinatal …

Surgical Revision In The Presence Of An S. Aureus Infection Increases Virulence Factor Expression And Activates A Multi-Tissue Inflammatory Response, Carly J. Smith, Arianna J. Moniodes, Amanda R. Watkins, Autumn G. Melvage, Thomas P. Thompson, Eirene Choi, Abigail A. Lucas, Brendan F. Gilmore, Thomas P. Schaer, Noreen J. Hickok, Theresa A. Freeman

Department of Orthopaedic Surgery Faculty Papers

Replacing implanted medical hardware due to infection often requires one or more revision surgeries. Each surgery triggers a tissue injury response and disrupts the established bacterial biofilm. However, the complex tissue response to reinjury and biofilm disturbance is not well understood. Our results show that with an existing infection, immunological niches such as the bone marrow, lymph nodes, and circulating blood further upregulate pro-inflammatory programs in response to revision. Rather than reducing bacterial burden, this heightened inflammation provokes virulence factor expression and tissue damage, including bone osteolysis and muscle fibrosis. While muscle fibrosis appears transient and begins resolving by 14 …

Endocrine Disrupting Chemicals And Adrenal Gland​, Gülay Şi̇mşek Bağir, Melek Eda Ertörer

Turkish Journal of Medical Sciences

Endocrine disrupting chemicals (EDCs) are exogenous compounds that have hormone-like effects inside the body. Endocrine disruptors can affect adrenal glands in humans and animals. Adrenocortical dysfunction related to chemical exposure has been reported in the literature.The human adrenal gland is crucial for the synthesis of steroid hormones (glucocorticoids, mineralocorticoids, and androgens) and amino acid-derived hormones (epinephrine and norepinephrine). All steps in the adrenocortical steroidogenesis pathway are potential targets for chemical inhibition, including the adrenocorticotropic hormone receptor, steroidogenic acute regulatory protein, mitochondrial cytochrome P450 (CYP) enzymes (CYP11A1, CYP17, CYP21, CYP11B1, and CYP11B2), and 3-hydroxysteroid dehydrogenase D4,5 isomerase. EDCs either inhibit the …

Endocrine-Disrupting Chemicals In Metabolic Bone Diseases, Including Osteoporosis, Betül Gündüz, Eli̇f Kiliç Kan, Ayşegül Atmaca

Turkish Journal of Medical Sciences

Endocrine disruptors are chemical substances widely utilized across various industrial sectors. Due to their structural similarity to natural ligands, they bind to receptors and influence the endocrine system via agonist–antagonist mechanisms. Exposure occurs through the consumption of contaminated food and water, inhalation of polluted air and dust, and dermal contact. Owing to their dynamic remodeling capacity, bones represent potential targets for endocrine-disrupting chemicals. These chemicals can disrupt bone formation, skeletal development, hormonal regulation, and calcium metabolism. Sensitivity to endocrine-disrupting chemicals is greatest during the prenatal and early postnatal periods. This review summarizes the effects of endocrine-disrupting chemicals on bone tissue.

Differences In Lactation Curve Parameters And Milk Yield Responses Between Artificially Induced And Naturally Calved Cows Milked In An Automatic Milking System, Marcos Busanello

Turkish Journal of Veterinary & Animal Sciences

Despite advances in artificial induction of lactation (AIL) protocols, they do not perfectly mimic the hormonal patterns of natural pregnancy. Recent studies show improved milk yield (MY) responses; however, comparisons of lactation curve parameters between AIL and naturally calved (NC) cows often do not extend beyond 305 days in milk (DIM). Thus, this study aimed to compare MY responses and lactation curve parameters between AIL and NC cows milked in an automated milking system (AMS). Data from 38 Holstein cows (19 AIL and 19 NC) were analyzed, focusing on the 305 DIM period. Wood’s lactation curve model was used to …

Antimicrobial Sensitivity Of Bacterial Isolates And Molecular Detection Of Staphylococcus Aureus And Staphylococcus Pseudintermedius Isolated From Urinary Tract Infections Of Canines, Mankaran Kaur, Gursimran Filia, Ashok Kumar

Turkish Journal of Veterinary & Animal Sciences

Urinary tract infections (UTIs) are commonly encountered in canine clinical cases and can result in significant health complications if not properly treated. This study isolated and identified bacterial pathogens from dogs with clinical signs of UTI. Antimicrobial susceptibility profiling was performed on the bacterial isolates and further molecular detection of Staphylococcus aureus and Staphylococcus pseudintermedius was also performed. A total of 104 urine samples were collected via cystocentesis and catheterization. Bacterial identification was conducted using standard bacteriological procedures, and antimicrobial susceptibility was assessed using the disc diffusion method with 21 different antimicrobial discs. Polymerase chain reaction (PCR) was used for …

Evaluation Of Blood-To-Fluid Gradient Of Glucose And Lactate As Biomarkers In The Early Diagnosis Of Septic Peritonitis In Dogs, Silpa Sn, Sujata Turkar, Neetu Saini, Sushma Chhabra, Kuldip Gupta, Gursimran Filia

Turkish Journal of Veterinary & Animal Sciences

Septic peritonitis is a serious, life-threatening condition with a high mortality rate. Accurate diagnosis is crucial for the survival of the affected animal. The present study analyzed the use of a blood-to-fluid gradient of glucose and lactate as a biomarker in the diagnosis of septic peritonitis. Thirteen dogs with septic peritonitis and nine dogs with aseptic peritonitis were included in this study. Blood-to-fluid glucose gradient was significantly high, and blood-to-fluid lactate gradient was significantly low in septic peritonitis compared with the aseptic peritonitis. A blood-to-fluid glucose gradient of ≥12 mg/dL showed 100% sensitivity and 55.6% specificity, whereas a blood-to-fluid lactate …

Determination Of The Cecal Microbiota Profile Of Anadolu-T Broiler Breeder Chickens Using 16s Metagenomic Sequencing, Kürşat Teti̇k, İsmai̇l Özkan, Serpi̇l Kahya Demi̇rbi̇lek

Turkish Journal of Veterinary & Animal Sciences

The gut microbiota has significant effects on the performance, health status, and immune systems of chickens. The complex microbial community structure begins to form after chicks hatch with the intake of feed, water, and air into the digestive system. Disrupting the balance of this system can lead to the proliferation of pathogenic microorganisms. Until recently, studies on microbiota relied on traditional microbiological techniques that cultured only a small fraction of the microbial diversity. However, significant advancements in DNA sequencing and bioinformatics have enabled the identification of diverse bacterial populations in environmental samples. In this study, a total of 2000 broiler …

Parameter Optimization For Runs Of Homozygosity (Roh) Detection In The Pig Genome, Timofey Romanets, Anna Korobeynikova, Lyubov Getmantseva, Maria Kolosova, Elena Romanets, Ilona Bakoeva, Varvara Shevtsova, Anatoly Kolosov, Alexander Maksimov, Siroj Bakoev

Turkish Journal of Veterinary & Animal Sciences

The present study analyses the influence of various parameters on the accuracy and reliability of ROH identification procedures, as well as their relationship with inbreeding and genetic diversity in Duroc pig populations. The genotyping data of 70 Duroc pigs obtained using PorcineSNP80v1 chips were used, and the effects of LD pruning and ROH calling parameters were evaluated. It was found that the use of strict basic filters during the execution of the --homozyg command reduces the likelihood of false positives and contributes to the more accurate identification of ROH. The results show that LD pruning reduces the detection of random …

Determination Of Serum Cortisol Levels As A Stress Marker In Hospitalized Dogs, Emre Tüfekçi̇, Gencay Eki̇nci̇, İlknur Karaca Bekdi̇k, Ali̇ Cesur Onmaz, Öznur Aslan, Vehbi̇ Güneş, İhsan Keleş, Mehmet Çi̇ti̇l

Turkish Journal of Veterinary & Animal Sciences

In veterinary medicine, various diseases and surgical procedures may require the isolation and hospitalization of dogs, allowing for more effective individual patient monitoring and increasing the chance of successful treatment by preventing unnecessary drug use. However, this process can be stressful. Our study aimed to determine the changes in cortisol levels, one of the primary stress hormones responsible for stress responses, in individually hospitalized dogs. In addition, epinephrine (EPN) levels, another stress marker, as well as hematological and some biochemical values were measured and vital signs were recorded. The dogs included in the study were divided into 3 groups: healthy, …

The Influence Of Endocrine Disrupters On Gut Microbiota, Kader Ugur

Turkish Journal of Medical Sciences

Endocrine disruptors (EDs) are closely associated with the second brain, the microbiota-derived enteric nervous system, commonly referred to as the gut microbiota. The microbiota plays a crucial role in human health and the development of diseases. In today’s industrialized world, the presence of EDs in air, water, and soil leads to primary human exposure through dermal contact and ingestion. The impact of these EDs on the microbiota remains unclear. EDs that disrupt the balance of the gut microbiota may contribute to a range of disorders, including metabolic (obesity, diabetes mellitus), cardiovascular (vascular stenosis, cerebrovascular disease), reproductive (infertility, ovarian and testicular …

Endocrine-Disrupting Chemicals And Thyroid Cancer, Özge Baş Aksu, Mustafa Şahi̇n

Turkish Journal of Medical Sciences

Environmental endocrine-disrupting chemicals (EDCs) have emerged as a critical global health concern because of their role in various diseases, including thyroid cancer. Defined as exogenous substances that disrupt endocrine system functions, EDCs can affect multiple generations through mechanisms such as hormone receptor modulation, altered hormone synthesis, and epigenetic modifications.The increasing global incidence of thyroid cancer has heightened interest in environmental factors, with EDC exposure recognized as a significant contributor. Compounds such as heavy metals, persistent organic pollutants, per- and polyfluoroalkyl substances, and bisphenol A play crucial roles in disrupting thyroid homeostasis. Emerging evidence underscores the synergistic effects of multiple EDC …

Effects Of Endocrine Disruptors On The Neurological System, Kadi̇rcan Karatoprak, Soner Cander

Turkish Journal of Medical Sciences

Background/aim: There is increasing interest in endocrine disrupting chemicals because of the potential effects on neurological health. These chemicals are widely found in various consumer products and industrial processes, and can lead to serious disorders of the endocrine system by disrupting hormone synthesis, expression, and function. The aim of this review was to examine epidemiological and experimental findings by investigating the link between exposure to endocrine disrupting chemicals and adverse neurological outcomes.

Materials and methods: In the preparation of this review, a PubMed literature search was conducted using the words “endocrine disruptors,” “neuroendocrine effects,” “neurobehavioral effects,” and “neurodevelopmental effects” and …

Endocrine Disruptors And Pregnancy, Betül Yi̇ği̇t Yalçin, Gamze Bi̇li̇k Oyman, Ayşe Kubat Üzüm

Turkish Journal of Medical Sciences

Sensitivity to endocrine disruptors is higher in early life. In pregnant women, endocrine disruptor chemicals can be passed to the baby through the placenta or through breast milk during lactation, leading to long-term and permanent adverse effects. These endocrine disruptors may cause adverse effects in women such as infertility, implantation defects, premature birth, spontaneous abortions, gestational hypertension, gestational diabetes. Exposure to endocrine disruptors in the intrauterine period may result in adverse effects on the reproductive system, metabolic changes, low birth weight, retardation in mental and physical development and also may be associated with congenital malformations. It is of great importance …

Endocrine Disruptors, Insulin Resistance, And Diabetes, Meri̇ç Coşkun, Ethem Turgay Ceri̇t, Tuğba Barlas, Alev Eroğlu Altinova

Turkish Journal of Medical Sciences

Endocrine-disrupting chemicals (EDCs) are compounds that interfere with hormone synthesis, secretion, metabolism, or excretion. Evidence indicates that increased exposure to EDCs is associated with insulin resistance and, most notably, type 2 diabetes worldwide. This suggests a diabetogenic effect that is independent of obesity, underscoring the complex mechanisms and broad impact of EDCs on metabolic health. Key pathways include hormone mimicry and antagonism, altered hormone metabolism, inflammatory responses, and mitochondrial dysfunction. This review summarises the mechanisms through which EDCs contribute to these conditions and evaluates the epidemiological and experimental evidence supporting these associations.

The Effects Of Endocrine Disruptors On The Female Reproductive System, Riza Gökhan Baykal, Reyhan Ersoy

Turkish Journal of Medical Sciences

Endocrine-disrupting chemicals (EDCs) are a diverse, comprehensive group of mostly synthetic chemicals that disrupt many physiological functions in humans and animals. EDCs are particularly disruptive to the female reproductive system. Reproductive function in women is a dynamic process regulated by the hypothalamic–pituitary–ovarian axis. EDCs show their effects on the reproductive system through estrogenic, antiestrogenic, androgenic, and antiandrogenic effects or by directly affecting gonadotropin-releasing hormone secretion. Disruption in the menstrual cycle, decrease in fertility, infertility, increased risk of miscarriage, polycystic ovary syndrome, endometriosis, early or delayed puberty, and hormone-sensitive cancers can be listed as the main negative effects of endocrine disruptors …

Effects Of Endocrine Disruptors On Thyroid Hormone Synthesis And Function And Consequences Of Fetal Exposure, Esra Eraslan Aydemi̇r, Mustafa Şahi̇n

Turkish Journal of Medical Sciences

Fetal development relies on intricate maternal-fetal-placental interactions, with thyroid hormones playing a critical role in growth and neurogenesis. Exposure to endocrine-disrupting chemicals (EDCs) during pregnancy has emerged as a significant risk factor for thyroid dysfunction and its associated developmental and cognitive disorders. EDCs, including bisphenol A (BPA), polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), perfluorinated compounds (PFAS), pesticides, and heavy metals, disrupt thyroid hormone synthesis, secretion, and metabolism. Mechanisms include binding to thyroid hormone receptors, impairing the hypothalamic-pituitary-thyroid axis, and altering thyroid peroxidase activity. BPA exposure, for instance, reduces free and total T4 levels and interferes with deiodinase activity. Similarly, …

The Impact Of Average Principal Diabetes Cost On Population Health Measures Within Homogeneous Demographics, Alvin Dwayne Binns

Doctoral Dissertations and Projects

The United States healthcare sector has encountered an increasing burden from diabetes health conditions and diabetes expenditures. Vulnerable populations are disproportionately affected, resulting in increased health mortality and morbidity. This quantitative retrospective, observational, cross-sectional cohort study identified the relationship between the average principal diabetes cost and population measures for Alabama Medicare beneficiaries living in homogeneous communities diagnosed with the principal diagnosis of diabetes. The theoretical framework guiding the study was the socio-ecological theory. Purposive sampling was applied to the secondary Mapping Medicare Disparities data population comprising 57 United States territories and 3,243 counties. Specifically, Medicare beneficiary participants diagnosed with the …

Vesicle-Mediated Mitochondrial Clearance Presents An Actionable Metabolic Vulnerability In Triple-Negative Breast Cancer, Jody Vykoukal, Yihui Chen, Mingxin Zuo, Riccardo Ballarò, Monica J Hong, Hansini Krishna, Daniela B Rodriquez-Perera, Hiroyuki Katayama, Ehsan Irajizad, Ranran Wu, Ricardo A León-Letelier, Jennifer B Dennison, Angelica M Gutierrez, Adriana Paulucci-Holthauzen, Timothy C Thompson, Leona Rusling, Yining Cai, Fu Chung Hsiao, Soyoung Park, Banu Arun, Samir Hanash, Johannes F Fahrmann

Faculty, Staff and Student Publications

Selective autophagy of mitochondria is known to promote cancer cell survival and progression, including in triple-negative breast cancer (TNBC). Here, we apply an integrated multi-omics approach together with functional experimental analyses to investigate metabolic adaptations that support mitochondrial quality control in TNBC. We detail a mitochondrial quality control mechanism, complementary to mitophagy, that is enabled by a program of heightened extracellular sphingomyelin salvaging in TNBC coupled with extracellular vesicle-mediated intracellular clearance of mitochondrial damage. Targeting of this onco-metabolic pathway via repurposing of eliglustat, a selective small molecule inhibitor of glucosylceramide synthase, results in ceramide-mediated compensatory mitophagy and cancer cell death …

Lung Adenocarcinoma Surfaceome Remodeling With Egfr Inhibitors Uncovers Placental Alkaline Phosphatase As A Target For Combination Therapy, Yihui Chen, Rongzhang Dou, Monica J Hong, Hanwen Xu, Jody Vykoukal, Ricardo A León-Letelier, Yining Cai, Soyoung Park, Ehsan Irajizad, Fu Chung Hsiao, Jennifer B Dennison, Edwin J Ostrin, Johannes F Fahrmann, Hiroyuki Katayama, Samir M Hanash

Faculty, Staff and Student Publications

Treatment of lung adenocarcinomas (LUADs) that exhibit activated epidermal growth factor receptor (EGFR) with EGFR tyrosine kinase inhibitors (TKIs) has limited efficacy. Assessment of the impact of EGFR TKI on the LUAD surfaceome remodeling reveals potential therapeutic targets. We identify placental type alkaline phosphatase (ALPP), which has restricted expression in normal tissues, among upregulated surface proteins following EGFR TKI treatment of both TKI sensitive as well as resistant cells. EGF treatment represses ALPP expression, whereas EGFR TKIs upregulate its expression through dephosphorylation and activation of FoxO3a, a transcriptional regulator that binds to the promoter region of ALPP. The combination of …

Intracranial Injection Of Genetically Modified, Mosquito Non-Transmissible Zika Virus: Safety In Primates And Ramifications For Brain Tumor Therapy, Alec J Hirsch, Amanda De Andrade Costa, Emilie Russler-Germain, Ashwani Kesarwani, Yuping Li, Michael S Diamond, Milan G Chheda, Et Al.

2020-Current year OA Pubs

Glioblastomas (GBMs) are incurable brain tumors. Zika virus (ZIKV) has specificity in killing GBM stem cells, which drive treatment resistance. In mouse models of GBM, ZIKV also generates an anti-tumor inflammatory response and prolongs survival. To support clinical development and address safety concerns for intra-tumoral treatment, we assessed the effects of injection of an immune-sensitized ZIKV (Δ10 3'-UTR ZIKV), which cannot be transmitted by mosquitos, into non-tumor-bearing rhesus macaque brains. After injection, the primates showed no clinical signs of illness. Histologically, as expected, ZIKV infection elicited mild inflammation, which resolved within 2 weeks. No infectious virus was detected in the …