Digital Commons Network^™

Reproductive Performance Of Friesian Holstein Crossbred Dairy Cattle After A Foot-And-Mouth Disease Outbreak In Lembang, Indonesia, Hanunghanindito Pamungkas, Septiyani Septiyani, Nurcholidah Solihati

Jurnal Ilmu Ternak Universitas Padjadjaran

Foot-and-mouth disease (FMD) is a highly contagious viral disease that may impair reproductive efficiency in dairy cattle. This study aimed to evaluate changes in the reproductive performance of Friesian Holstein crossbred dairy cows following an FMD outbreak at UPTD BPTSP and HPT Cikole, Lembang, West Java, Indonesia. A retrospective study was conducted using reproductive records collected from 2019 to 2023. The reproductive parameters analyzed were calving interval, service per conception, conception rate, service period, and first mating postpartum. Differences between the pre- and post-FMD periods were assessed using paired sample t-tests. The results showed significant differences in calving interval, service …

Polymorphism Of The Mx Gene In Riau Kampung Chickens, Elfawati Elfawati, Restu Misrianti, Sadarman Sadarman

Jurnal Ilmu Ternak Universitas Padjadjaran

One of the genetic markers for avian influenza is the Mx gene. The purposed of this study was to determine the polymorphism of the Mx gene of kampung chicken in Riau Province. A total of 61 samples from three subpopulations have been genotyped using PCR-RFLP. Allele and genotype frequencies have been calculated using PopGene. The Mx gene was amplified, producing a DNA fragment measuring 299 base pairs. This fragment was digested with the Hpy81 enzyme, which yielded three genotypes: the AA genotype showed by a single 299 bp band; AG showed by 299, 200, and 99 bp bands; and GG …

The Potency Of Inulin Extraction Waste Fermentation From Local Tubers As A Feed Additive, Mohamad Septian, Danes Suhendra, Mikael Sihite, Dyah Saputri

Jurnal Ilmu Ternak Universitas Padjadjaran

This study aims to determine the potential of inulin extraction waste fermentation as a feed additive based on the content of lactic acid, dry matter, pH, and Fleigh points. This research was conducted from March to June 2022 at the Animal Husbandry and Fisheries Laboratory, Tidar University. The experimental design used in this study was a Completely Randomized Design with 4 treatments (fermentation of inulin extraction waste: T1 Dioscorea alata (uwi), T2: ganyong (Dioscorea alata discolor), T3: gadung(Dioscorea hispida), and T4: umbi ungu (Ipomoea batatas). Each treatment was replicated 5 times. The variables …

The Potential Of Bioactive Peptides From Goat Milk Kefir With Antibacterial Activity As An Antibiotic Substitute, Dhea Athillah, Jajang Gumilar, Eka Wulandari

Jurnal Ilmu Ternak Universitas Padjadjaran

This study aims to determine the optimal incubation time for goat milk kefir that produces the highest antibacterial peptides, and to determine the antibacterial activity of purified goat milk kefir. Protein levels were determined using the microassay method. Kefir, which is known to have the best incubation time for producing the highest antibacterial activity when ultrafiltered with a 10 kDa cut-off membrane, was analyzed for its molecular weight using SDS-PAGE. The antibacterial activity was tested against pathogenic bacteria E. coli and S. aureus. The highest soluble protein content was found in kefir incubated for 36 hours, with a soluble …

Exploring The Impact Of A Multifaceted Standardized Wellness Program On Physical, Mental, Emotional, And Spiritual Health In Nurse Anesthesia Students, Lauren Kulaszewski, Amber Hurt

Scholars Week

Abstract

Purpose

Nurse anesthesia students experience substantial academic and clinical stress, placing them at increased risk for anxiety, depression, burnout, and suicidal ideation. Despite this risk, there is limited guidance on the effectiveness of standardized, programmatic wellness initiatives in nurse anesthesia education. The purpose of this project was to evaluate whether implementation of a standardized wellness program, compared with reliance on independent student-initiated practices, could improve mental, physical, emotional, and spiritual well-being among second- and third-year nurse anesthesia students.

Methodology

A pre–post intervention design was used over a six-month period at a large academic institution. Second- and third-year nurse anesthesia …

Quality Improvement Project: Educating Nursing Faculty On Animal-Assisted Therapy: Enhancing Knowledge And Confidence To Improve Program Outcomes, Sarah J. Whitwell

Doctor of Nursing Practice Projects

The purpose of this quality improvement project was to evaluate whether an educational intervention on animal-assisted therapy (AAT) improved nursing faculty perceived knowledge and confidence in using AAT to improve program outcomes. The problem addressed was the limited knowledge and confidence among nursing faculty regarding the use of non-traditional, evidence-based strategies to support student mental health. This project was guided by the Stetler Model of Evidence-Based Practice and Lewin’s Change Theory and used a quasi-experimental, one-group pre–post design. The project was conducted with nursing faculty teaching in a baccalaureate program at a four-year public university in Oklahoma. A 10-item Likert-scale …

Dietary Patterns And Nutritional Status In Soccer Athletes: A Cross-Sectional Study From An Ergonomic Perspective, Rina Mayangsari, Ravi Masitah

Indonesian Journal of Research in Physical Education, Sport, and Health

Background: Normal nutritional status has been established as one of the principal determinants in an athlete's performance. Dietary quality plays a critical role in optimizing athletes' physical fitness and performance outcomes. Objective: To examine the associations between dietary patterns on the MacPersona System and nutritional status of soccer players (energy, protein, et cetera, fat, and carbohydrates). Methods: A cross-sectional quantitative study was conducted involving 21 soccer players (total sampling). Dietary patterns were assessed using a validated Semi-Quantitative Food Frequency Questionnaire (SQ-FFQ). Nutritional status was measured using Body Mass Index(BMI) based on anthropometric data. The chi-square test was used for statistical …

The Relationship Between Macronutrient Intake And Cardiometabolic Indicators In College Students Who Regularly Exercise, Yosef Ferdy Yangkara, Akhmad Lutfi, Bagus Kusuma Putra, Siti Baitul Mukarromah, Adi S

Indonesian Journal of Research in Physical Education, Sport, and Health

Background: Macronutrient intake plays a crucial role in determining body composition and cardiovascular health. Studies that simultaneously examine macronutrient intake and various cardiometabolic indicators in physically active populations without a clinical history remain limited. Objective: This study aims to analyze the relationship between macronutrient intake and BMI, blood pressure, and heart rate among a gymnastics community at Semarang State University. Methods: The study used a cross-sectional design involving 30 students (12 males and 18 females) aged 18–35 years, selected through purposive sampling. Macronutrient intake data were collected using a 2×24-hour food recall method, while BMI, blood pressure, and heart rate …

Snip Or Skip? Consumer Attitudes And Marketing Message Development For Spay/Neuter Efforts, Rebecca Burcham

Atlantic Marketing Association Proceedings

No abstract provided.

Epidemiological Survey Of Abortion In Camels (Camelus Dromedarius) And Histopathological Investigation Of Toxoplasmosis And Neosporosis In Those Animals From Slaughterhouses In Southeastern Algeria, Amira Djeddou-Benabid, Hind Houssou, Omar Bennoune, Ferhat Nouicer, Amel Djaout

The Thai Journal of Veterinary Medicine

Toxoplasma gondii and Neospora caninum are heteroxenous apicomplexan parasites recognized as major causes of reproductive disorders in numerous mammalian species. The present study aimed to assess through an epidemiological survey, the prevalence of reproductive losses in 75 dromedary herds during the period 2022-2025, as well as the associated risk factors, and to detect these protozoa by histopathological analysis in 63 dromedaries slaughtered at the slaughterhouse of El Oued province (126 samples: 63 hearts and 63 diaphragms). The survey revealed that 80% of the herds had a history of abortions, of which 60% also reported cases of stillbirth. Risk factor analysis …

The Effect Of The Mind Diet On Cognitive Decline In Als Patients With Frontotemporal Dementia, Riya Thomas, Reba Thomas, Eliana Gitelman

Department of Nutrition Student Projects

Amyotrophic lateral sclerosis (ALS) is a progressive disease that affects nerve cells in the brain and the spinal cord, leading to a broad range of neurological issues. Individuals with ALS experience progressive muscle weakness, dysphagia, slurred speech, and impaired movement and cognition. In addition to physical symptoms, around 15-20% of individuals with ALS also develop frontotemporal dementia (FTD). There are limited interventions to slow cognitive decline in this specific population. The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet has been associated with slower cognitive decline and reduced risk in neurodegenerative disease among older adults; however, its effects have not been …

Therapeutic Potential Of Bacillus Coagulans Unique Is2 Probiotic Supplementation On Early Periodontitis Patients: A Randomized Controlled Trial, Renu Gaur, Aysha Jebin A, Prabhuji M L V

International Arab Journal of Dentistry

Objectives: Bacillus coagulans (B. coagulans) is a probiotic commonly used for broad spectrum of systemic infections, its potential to treat oral infections, particularly periodontitis, is still being studied.The aim of the study was to evaluate the efficacy of probiotic B. coagulans as an adjunct to SRP in periodontitis patients.

Methods: Thirty systemically healthy patients with stage I/ stage II and grade A/ grade B periodontitis were selected and randomly divided into two groups. The control group received SRP along with placebo and the test group received SRP + B. coagulans probiotic chewable tablets. At baseline, one month, and three months …

Biologically Oriented Preparation Technique In Implant-Supported Fixed Prostheses: A Systematic Review, Ghida Lawand, Roudy Khayat, Yara Ismail, Maryse Nassif, Mahmood Dashti, Jimmy Londono, Rami Al Bahri, Hani Tohme

International Arab Journal of Dentistry

This systematic review was conducted to assess the clinical and esthetic outcomes associated with convergent collar implants and compare them to divergent collar implant. The review was registered on the PROSPERO register (registration number: CRD42022326338). The systematic literature search was conducted in accordance with PRISMA guidelines to identify studies on implant-supported prostheses related to the Biologically Oriented Preparation Technique (BOPT) until June 2023. Inclusion criteria involved experimental and clinical studies published in peer-reviewed journals, excluding expert opinions. Data extraction was performed, adhering to predefined parameters for BOPT, specifications of convergent collar implants, and the assessment of outcomes. The systematic review …

Balneotherapy For Sleep Improvement And Reducing Depression In Knee Osteoarthritis Patients, Anca Paula Ciurba, Alexandru Bogdan Ilieș, Ionel Haidu, Doriana Ioana Ciobanu, Theodora Ursu, Florin Mihai Marcu, Dorina Ianc

Baltic Journal of Health and Physical Activity

Background: Knee osteoarthritis (OA) is the most common chronic condition and a leading cause of global disability, often associated with pain, depression, and sleep disturbances. The purpose of this study was to investigate the effectiveness of warm mineral water combined with physical therapy on sleep quality, depression and pain intensity in patients with knee osteoarthritis. Materials and Methods: The study involved 101 subjects (68.78±6.92 years) who were assigned to  a control group (CG) or an experimental group (EG). All subjects benefited from physical therapy and electrotherapy for 10 days. The experimental group additionally benefited from therapy with hot mineral water. …

Ultrasound-Guided Percutaneous Sclerotherapy Of A Canine Hepatic Cyst Using Lower-Concentration Ethanol: A Case Report, Minyoung Kim, Dongyeong Lee, Seulgi Bae, Sang-Kwon Lee, Kija Lee

The Thai Journal of Veterinary Medicine

A 10-year-old female Pomeranian was referred after a hepatic cyst was incidentally identified during a routine health check. Ultrasound-guided simple drainage was initially performed, and cytological examination of the aspirated fluid confirmed a simple cyst. However, the cyst re-expanded to its original size within 2 weeks. Therefore, ultrasound-guided percutaneous sclerotherapy was elected using lower-concentration ethanol (83%), a readily available medical disinfectant, rather than conventional high-concentration ethanol. Approximately 50% of the aspirated volume was replaced with 83% ethanol and retained for 20 min to achieve effective epithelial ablation. Post-procedural follow-up revealed a transient increase in cyst size and serum alanine aminotransferase …

Ultrasonography Accompanied By Genetic Testing In Feline Polycystic Kidney Disease, Thao Phuong Vu, Thong Quang Le, Ha Nguyen Nhat Tran, Khoa Hoang Dang Le, Anh Phu Nam Bui

The Thai Journal of Veterinary Medicine

Autosomal dominant polycystic kidney disease (ADPKD), caused by the PKD1 c.10063C>A mutation, is a prevalent inherited feline disorder, but its allele frequency in Vietnam remains unidentified. This study aimed to determine the carrier frequency of this variant in British Shorthair, Maine Coon, and Ragdoll cats in Ho Chi Minh City and to correlate genotype with ultrasonographic phenotype. Ninety-seven client-owned cats were genotyped for the pkd1 mutation using PCR-RFLP. A subset of 47 cats also underwent abdominal ultrasonography to detect renal cysts. Genotypic results were correlated with sonographic findings, and risk factors were analyzed using chi-square tests and odds ratios …

Opium Of The Masses: An Analysis Of Archeobotanical Research In The City Of Tábor, Czechia And How It Potentially Influenced Forms Of Radical Hussism, Sasha Gladding

Undergraduate University Honors Capstones

Opium of the Masses performs in depth analysis of the Hussite Wars–a time period lasting from 1419 to 1436, Jan Hus, Hussite factionalism, and archeobotany. This analysis proposes that there are numerous possible contributing factors to the development of the radical Hussite teachings and ways of life. The instability of the Catholic hierarchy and the dissenting teachings of Jan Hus also likely were contributors to the development of the unique sociopolitical and spiritual practices of the radical Hussites. It is also possible that the Hussite factions residing in the Czech (then Bohemian) town of Tábor utilized opium as an entheogen …

Claudins Interact With Lilrb Immune Inhibitory Receptors To Promote Myeloid Immunosuppression In Cancer, Xiaoye Liu, Ryan Huang, Zhiqiang Ku, Jingjing Xie, Heyu Chen, Yubo He, Qi Lou, Chengcheng Zhang, Xing Yang, Cheryl Lewis, Jade Homsi, Ankit Gupta, Lei Dong, Kenian Chen, Annabel Tu, Liming Du, Hailong Yu, Qing Hu, Meng Fang, Bufan Li, A E M Adan Khan, Caroline Simith, Samuel John, Lin Xu, Ningyan Zhang, Zhiqiang An, Cheng Cheng Zhang

The Brown Foundation: Institute of Molecular Medicine

The mechanisms underlying tumor cell-myeloid cell interactions in the tumor microenvironment (TME) remain unclear, and predictive biomarkers for patient response to myeloid checkpoint blockade are lacking. This study identified specific binding between tight junction claudins (CLDNs) and leukocyte immunoglobulin-like receptor subfamily B2 (LILRB2) and LILRB5. In multiple human cancer cohorts, the spatial proximity of LILRB2-positive macrophages to CLDN-expressing cancer cells correlated with clinical outcomes, highlighting this spatial relationship as a potential biomarker. In syngeneic LILRB2-transgenic and humanized mouse models, CLDN18.2-LILRB2 interactions triggered bidirectional signaling, enhanced the immunosuppressive activity of myeloid cells, and accelerated tumor progression. These effects were reversed by …

Translationally-Relevant Tumor Resection Model For Murine Preclinical Models Of Oral Squamous Cell Carcinoma, Gemalene M Sunga, Alejandra Cobos Perez, Andrea H Molina, Nourhan Hussein, Neeraja Dharmaraj, Andrew Sikora, Simon Young

Faculty, Staff and Student Publications

Currently, the first-line treatment for the most common form of head and neck squamous cell carcinoma (HNSCC), oral cavity squamous cell carcinoma (OSCC), is surgical resection, followed by risk-adapted treatments, such as chemoradiotherapy. However, with the current standard of care and even the emergence of new treatments, such as checkpoint blockade, the overall survival for advanced, recurrent disease remains high, and the prevalence of head and neck cancer is projected to continue to increase in the coming years. Thus, deeper investigation into current standard-of-care modalities, in addition to novel therapeutics, is necessary to translate potential and promising treatment options to …

Six-Week Time-Restricted Eating Lowers Premature Mortality Risk In Overweight Early Elderly Adults: Evidence From A Body Shape Index, Przemysław Domaszewski, Mariusz Konieczny

Baltic Journal of Health and Physical Activity

Background: A Body Shape Index (ABSI) is an anthropometric indicator combining waist circumference, weight, and height, providing a BMI-independent measure of central obesity and a recognized predictor of mortality. Despite its relevance, research on ABSI in early elderly populations remains limited. This study assessed the impact of a six-week time-restricted eating (TRE) intervention on ABSI z-scores in overweight adults aged 65–74, with attention to gender differences. Materials and Methods: A total of 116 participants were randomized into a TRE group (16:8 fasting window from 8:00 PM to 12:00 PM) or a control group maintaining habitual eating. ABSI z-scores were evaluated …

Changes In 25(Oh)D Concentration, Bone Resorption Markers And Physical Performance Due To Sun Exposure, Diet And Training Load Among Professional Women Handball Players During The Half-Year Training Season, Sorin Dacian Buhas, Zbigniew Jastrzębski, Paul Florian Dragos, Marius Alin Marinau, Maria Skalska, Mirela Stef, Joanna Jastrzębska, Mihai Sandra, Dana Ioana Cristea

Baltic Journal of Health and Physical Activity

Background: The aim of the study was to demonstrate changes in 25(OH)D concentration, bone resorption indicators and physical fitness in female handball players as a result of their exposure to the sun, diet and exercise load during the six-month training period from mid-March to mid-September, i.e. the time when the sun exposure is the highest during the calendar year. Twenty-two women handball players participated in the study. Due to the random occurrences and exclusion criteria, 20 players completed the project. Biochemical analysis of blood, aerobic capacity, running speed and power tests (Wingate test, squat jump, counter movement jump, etc.) was …

Evaluating The Relationship Between Vitamin D Supplementation, Lifestyle, Social Determinants Of Health, Asthma, And Respiratory Tract Infections, Yun O'Donnell

Walden Dissertations and Doctoral Studies

Hypovitaminosis D is a significant public health concern in the United States associated with inadequate sunlight exposure and insufficient dietary intake. Asthma is a chronic respiratory condition that progressively worsens over time. While asthma is typically managed through individual-level treatment approaches, population-level strategies such as vitamin D supplementation and food fortification policies have not been implemented. A five-tier Public Health Impact Pyramid theoretical foundation guided this nonexperimental quantitative cross-sectional study. Data from 2013-2014 and 2017-2018 NHANES (n = 1,456) was evaluated for relationships between vitamin D supplementation, duration of sunlight exposure, and food security index, with asthma, asthma exacerbation severity, …

Depolymerizing F-Actin Accelerates The Exit From Pluripotency To Enhance Stem Cell-Derived Islet Differentiation, Nathaniel J Hogrebe, Mason D Schmidt, Punn Augsornworawat, Sarah E Gale, Mira Shunkarova, Jeffrey R Millman

2020-Current year OA Pubs

In this study, we demonstrate that cytoskeletal state at the onset of directed differentiation impacts the exit of human pluripotent stem cells (hPSCs) from pluripotency and downstream lineage specification. In particular, depolymerizing F-actin with latrunculin A (latA) during the first 24 h of definitive endoderm formation facilitates efficient loss of pluripotency and alters Activin/Nodal, BMP, c-Jun, and WNT signaling dynamics. These signaling changes influence downstream patterning of the gut tube, leading to improved pancreatic progenitor identity and decreased expression of markers associated with other endodermal lineages. Continued differentiation generates islets containing a higher percentage of β cells that exhibit improved …

Innovator - Spring 2026

Innovator

06 - Message From the President

08 - Time Machine

12 - News

22 - Gabrielle Kemberling ’12

28 - The Oughton Family

34 - Beyond the Seams

44 - Question & Innovate

46 - Ram Roundup

48 - Which Ram Was the GOAT?

52 - Class Notes

56 - In Memory

58 - Trivia

Innovator - Summer 2024

Innovator

06 - A Message from the President

10 - Time Machine

16 - The Nexus

32 - Our History

38 - Weaving a Legacy of Excellence

40 - Bridging the Gaps

44 - Harnessing the Qualities That Create Healthcare Heroes

48 - Question & Innovate

52 - Alumni Impact

54 - Ram Roundup

58 - Be Kind

62 - Class Notes

68 - In Memory

70 - Trivia

Hypothermia Prevention In Major Trauma Patients, Alaina Hostetler

Doctor of Nursing Practice Scholarly Projects

Traumatic injuries present a significant health challenge for providers, often resulting in hypothermia, coagulopathy, and acidosis, referred to as the trauma triad of death. Hypothermia significantly impacts trauma patients' outcomes and exacerbates morbidity and mortality rates, particularly in trauma cases with high injury severity scores who require immediate surgical intervention. Despite the detrimental effects of hypothermia, evidence-based approaches to treating hypothermia in this population are lacking. Traditional warming methods heavily rely on provider preference and can lead to inconsistent care. Rapid, reliable, and effective resuscitation interventions are essential in the immediate care of major trauma patients. The proposed project will …

Feeding The Mind: Dietary Consumption And Neural Aging, Bhavani Tuppale

Senior Theses

Neural aging is the process of physiological decline in the brain and increased vulnerability to neurodegenerative diseases. Neurodegenerative diseases such as Alzheimer’s disease are associated with aging and the interaction of genetics and lifestyle choices. Previous research studies have connected Alzheimer’s disease with dysfunction in the metabolic system. To combat age-associated dysfunctions in the metabolic system, research studies propose using the ketogenic diet, which utilizes ketone bodies as an energy source instead of glucose. The thesis analyzes literature on the effect of neural aging on various model organisms, how a ketogenic diet affects aging model organisms, and how aging and …

Loss Of Sarm1 Affects Myelin Uptake And Clearance In Macrophages, Grace J. Bergeron

Senior Theses

Clearance of myelin debris is an essential step in nerve regeneration after injury in both the central nervous system (CNS) and peripheral nervous system (PNS), a process that is primarily carried out by macrophages. Failure to phagocytose and clear myelin can prolong inflammation and impair recovery. Sterile alpha and TIR motif-containing protein 1 (SARM1) is well researched as a regulator of axonal degeneration, yet its role in macrophages is still unclear. This study investigates how sarm1 deletion and cytokine signaling influence macrophage uptake and clearance of CNS and PNS myelin in vitro. Splenic macrophages isolated from wild-type (WT) and sarm1 …

Antibiotics And You: A Comprehensive Guide, Brady Haas

Senior Theses

Antibiotic resistance is a rapidly emerging issue within public health. As resistance grows, the effectiveness of traditional antibiotic therapies diminishes while risk of treatment grows. Alongside novel therapies, public knowledge is a strong combatant of the resistance-related risks of antibiotic usage. Through a comprehensive review of current literature, this work serves as an accessible guide to the mechanisms of antibiotics, bacterial resistance, and the challenges related to current antibiotic usage. Additionally, the ability of current policy and emerging novel treatments, such as nanoparticles and bacteriophage therapy, to fight antibiotic resistance is evaluated. This analysis highlights the importance of improving public …

Cell-Free Mitochondrial Dna (Mtdna) Triggers Vascular Dysfunction Via Toll-Like Receptor 9 (Tlr9)-Dependent Activation Of Inflammasomes, Mohin Amin

Senior Theses

Hypertension is the leading global risk factor for mortality and is closely associated with vascular inflammation and dysfunction. Damaged mitochondria release cell-free mitochondrial DNA (cf-mtDNA), which activates toll-like receptor 9 (TLR9). The binding of TLR9 to mtDNA activates the NLRP3 inflammasome pathway, promoting the release of pro-inflammatory cytokines via gasdermin D (GSDMD), therefore worsening inflammation. However, the mechanisms linking mitochondrial injury to inflammation-induced vascular dysfunction remain unclear. We hypothesize that cf-mtDNA triggers TLR9-dependent NLRP3 inflammasome activation contributing to vascular and endothelial dysfunction. To assess that, adult male C57BL/6 were exposed to 28 consecutive days of chronic unpredictable stress (CUS) or …