Digital Commons Network^™

Papillary Thyroid Carcinoma With Neck Pain: A Casereport, Shih-Wei Huang, Nai-Chiung Huang, Ta-Sen Wei, Tsung-Ju Wu

Rehabilitation Practice and Science

Papillary thyroid carcinoma is a type of well-differentiated thyroid cancer. This type of cancer is often diagnosed in patients found with palpable neck mass or lymph node enlargement. The clinical characteristics of papillary thyroid carcinoma are slow disease progression, less tendency for distant metastasis, and better prognosis than other types of thyroid cancer. The diagnosis of thyroid cancer is primarily based on the identification of pathological tissue obtained through echo-guide fine needle aspiration biopsy. In laboratory examinations, these patients may or may not be present with hypothyroidism.The subject in our case study is a 82-year-old male patient. He complains of …

The Effect Of A New Gelatinous Elastomers Cushion On Reducing Pressure And Temperature, Mu-Jung Kao, Yang-Hwei Tsuang, Chi-Jou Kuo, Jen-Ling Chou, Hung-Wen Wei, Mei-Wun Tsai

Rehabilitation Practice and Science

Objective: The aim of this study was to analyze the effectiveness of a new air cell cushion (Elaston cushion) made of gelatinous elastomers, a newly developed material with a novel structure on reducing pressure and temperature.Methods: We compared the pressure and thermal responses of the Elastone cushion to three other available cushions (foam, gel-filled and air-filled villous) and four regular wooden or spongy chair seats. The skin temperature at the buttocks was also continuously measured for eight-hours sitting. Results: The Elastone cushion reduced the peak pressure (39.7 mmHg) compared with foam (60.0 mmHg), gel-filled (60.3 mmHg) and air-filled cushions (69.3 …

The Prevalence Of Flatfoot In Taoyuan Teenagers, Huan-Jui Yeh, Huei-Yu Lo, Yau-Wai Wai

Rehabilitation Practice and Science

Background: The prevalence of flatfoot is various among each age group, and whether children with flatfoot should receive treatment or not is still controversial. Most studies of flatfoot in Taiwan place emphases on children but not on teenagers. This research aimed to establish a database of a prevalence of flatfoot among Taiwanese local teenagers.Methods: Five hundred forty-four 12- to 14-year-old teenagers in Taoyuan were enrolled in this study. Footprint analysis methods were used to diagnose a flatfoot (plantar arch index more than 1.15 or Denis grade equal or more than grade 1 or footprint index less than 1 cm). The …

Primary Reasons For Rehabilitation Service Referrals: The Recent Experience Of A Medical Center In Taiwan, Chung-Po Su, Ssu-Yuan Chen, Tyng-Guey Wang, Yen-Ho Wang, I-Nan Lien

Rehabilitation Practice and Science

Objectives: To better understand the current utilization of rehabilitation services and to project future trends, this study investigated the primary reasons for rehabilitation services referrals in a medical center in Taiwan. Methods: We reviewarticleed records of those patients who visited rehabilitation clinics (4,305 new and 12,163 returned patients) or received a rehabilitation consultation during their hospital stay (1,345 patients) between June and October 2007 at the National Taiwan University Hospital. The primary diagnoses of study patients were classified into 12 groups: musculoskeletal and soft tissue diseases, brain diseases, spinal cord diseases, peripheral neuropathy, myopathy, fractures and amputations, language disorders, cardiovascular …

Effect Of Perceptual Interference And Response Conflict On P300 Latency, Yu-Shen Huang, Fen-Fen Chen

Rehabilitation Practice and Science

Background: The latency of the P300 component of the event related-potential (ERP) is an index of stimulus classification speed. In this study, we assessed the mental chronometry of stimulus discrimination and decision execution by study the effect of congruence visual stimuli and and compatibility on ERP and reaction time.Methods: The reaction time was divided into two sections based on the peak amplitude of P300. P300 latency was defined as the discrimination time needed to interpret the stimulus. The time from the peak of P300 to the initiation of movement was defined as duration of response selection. We hypothesized that congruency …

Ultrasound Assessment Of Primary Pyomyositis In A Man With Uncontrolled Type 2 Diabetes: A Casereport, Ya-Chen Lee, Ya-Wen Tu, Wei-Ting Wu, Shao-Li Han

Rehabilitation Practice and Science

A 38-year-old man with uncontrolled type 2 diabetes mellitus complained of a mild painful swelling over the right posterior thigh that had been present for 3 days. He was initially diagnosed as having a right hamstring strain. After a 7-day treatment with non-steroidal anti-inflammatory drugs, the symptoms progressed to a prominent painful swelling over the right posterior thigh. Leukocytosis and high inflammation indices were noted. The ultrasonography of the right posterior thigh showed an ill-defined heteroechoic lesion surrounded by an irregularly thick hyperechoic and hypervascular wall in the muscle layer. The diagnosis was pyomyositis of the right biceps femoris muscle, …

Spinal Cord Injury And Diffuse Asymptomatic Pulmonary Embolism After Percutaneous Vertebroplasty: A Casereport, Yao-Jen Chen, Pei-Pi Shih, Su-Ju Tsai

Rehabilitation Practice and Science

A 30-year-old woman with a history of 9th to 11th thoracic vertebral compression fracture developed complete thoracic spinal cord injury immediately after percutaneous vertebroplasty. The patient did not have any sign of neurological recovery after two operations for spinal decompression. The postoperative chest X ray and thoracic computed tomography scan revealed diffuse asymptomatic pulmonary embolism, but the patient did not have dyspnea or chest pain.Percutaneous vertebroplasty has been generally considered a minimally invasive and effective procedure for treatment of painful compression fracture. Complications after percutaneous vertebroplasty include infection, spinal cord injury, cardiopulmonary complications and stroke. In previous literature search, there …

Radicular Pain As An Initial Presentation In Neuromyelitis Optica: A Casereport, Yen-Chou Lai, Wen-Sheng Liu, Shih-Fan Lin, Tsam-Ming Kuo, Ker-Hsiu Liao, Yen-Ting Lai

Rehabilitation Practice and Science

Neuromyelitis optica is a rare demyelinating disease. Radicular pain as the initial presentation of monophasic neuromyelitis optica has not been previously reported. We present a case of monophasic neuromyelitis optica in a 69-year-old female who suffered 1 year (from 2004/6 to 2005/5) from back pain that radiated to the lower extremities. Fifth lumbar radiculopathy was the first diagnosis. Despite treatment with laser discectomy on 2005/2/15, her pain, lower extremity weakness, and bilateral visual acuity worsened. Three weeks after surgery, she came to our hospital for help and was admitted for evaluation. The diagnosis of neuromyelitis optica was confirmed later. Prednisolone …

Early-Stage Myeloid Sarcoma Presenting As Back Pain In An Adolescent: A Casereport, Chao-Pin Yang, Shih-Chung Wang, Ta-Sen Wei, Sen-Yung Liu, Tsung-Ju Wu, Albert D. Yang

Rehabilitation Practice and Science

Myeloid sarcoma (MS) is a rare disease. MS is a malignant solid tumor resulting from the extramedullary proliferation of myeloblasts or immature myeloid cells.It is often described in association with acute myeloid leukemia (AML). In the absence of overt leukemia, MS is rarely considered in the differential diagnosis of a soft-tissue mass, and the diagnosis of MS is usually delayed or misdiagnosed. We present the case of a female adolescent who initially complained of back pain. Conservative treatment including medication and rehabilitation was given to her, but in vain, and the symptoms gradually progressed to severe neurological function loss, including …

Acetate Causes Alcohol Hangover Headache In Rats, Christina R. Maxwell, Rebecca Jay Spangenberg, Jan B. Hoek, Stephen D. Silberstein, Michael L. Oshinsky

Department of Neurology Faculty Papers

Background

The mechanism of veisalgia cephalgia or hangover headache is unknown. Despite a lack of mechanistic studies, there are a number of theories positing congeners, dehydration, or the ethanol metabolite acetaldehyde as causes of hangover headache.

Methods

We used a chronic headache model to examine how pure ethanol produces increased sensitivity for nociceptive behaviors in normally hydrated rats.

Results

Ethanol initially decreased sensitivity to mechanical stimuli on the face (analgesia), followed 4 to 6 hours later by inflammatory pain. Inhibiting alcohol dehydrogenase extended the analgesia whereas inhibiting aldehyde dehydrogenase decreased analgesia. Neither treatment had nociceptive effects. Direct administration of acetate …

Dna Methylation And Its Association With Prenatal Exposures And Pregnancy Outcomes, Jennifer Straughen

USF Tampa Graduate Theses and Dissertations

Altered DNA methylation may lead to suboptimal fetal programming, increasing the risk of adverse pregnancy outcomes such as small for gestational age (SGA); however, few studies have examined the associations between DNA methylation, prenatal exposures, and fetal outcomes. Cross-sectional data from a larger, ongoing study were used to assess the impact of prenatal smoking on gene specific methylation of umbilical cord blood derived DNA and to investigate the association between gene-specific methylation and risk of SGA. The association between gene-specific DNA methylation and birthweight was also assessed. Maternal and infant covariates were abstracted from medical records, cigarette smoke exposure was …

Evaluation Of Common Inherited Variants In Mitochondrial-Related And Microrna-Related Genes As Novel Risk Factors For Ovarian Cancer, Jennifer Permuth Wey

USF Tampa Graduate Theses and Dissertations

Epithelial ovarian cancer (EOC) is a leading cause of morbidity and mortality among women in the United States, and the etiology is incompletely understood. Common, low penetrant genetic variants such as single nucleotide polymorphisms (SNPs) likely contribute to a significant proportion of EOC. We examined whether SNPs in two understudied yet biologically important types of genes, mitochondrial-related and miRNA-related genes, may contribute to EOC susceptibility using data from a large, homogeneous study population of 1,815 EOC cases and 1,900 controls (frequency-matched on age-group and race/ethnicity) genotyped through stage 1 of an ongoing genome-wide association study. Inter-individual variation in genes involved …

Epidemiological Study Of Contributing Factors In The Development Of Peptic Ulcer And Gastric Cancer Initiated By Helicobacter Pylori Infection In India, Rahul Suresh Mhaskar

USF Tampa Graduate Theses and Dissertations

Background: Helicobacter pylori (H. pylori) infection is a significant risk factor for peptic ulcer (PU) and gastric cancer (GC). Apart from the virulent CagA genotype of H. pylori environmental and dietary factors influence disease outcomes. There have been no studies addressing these factors in Western India. Hence, we conducted a case control study enrolling PU, GC patients and controls at Pune, India.

Methods: Risk factors for PU and H. pylori infection were assessed in participant interview. H. pylori status was assessed from stool by monoclonal antigen detection. To understand treatment effect, we followed 100 H. pylori positive patients.

Results: We …

Pseudomonas Aeruginosa Β-Lactamase Induction Requires Two Permeases, Ampg And Ampp, Kok-Fai Kong, Alian Aguila, Kalai Mathee, Lisa Schnepper

Department of Biological Sciences

Background

In Enterobacteriaceae, β-lactam antibiotic resistance involves murein recycling intermediates. Murein recycling is a complex process with discrete steps taking place in the periplasm and the cytoplasm. The AmpG permease is critical to this process as it transports N-acetylglucosamine anhydrous N-acetylmuramyl peptides across the inner membrane. In Pseudomonadaceae, this intrinsic mechanism remains to be elucidated. Since the mechanism involves two cellular compartments, the characterization of transporters is crucial to establish the link.

Results

Pseudomonas aeruginosa PAO1 has two ampG paralogs, PA4218 (ampP) and PA4393 (ampG). Topology analysis using β-galactosidase and alkaline phosphatase fusions indicates ampP and …

The Ethics Of Placebo-Controlled Trials In Developing Countries To Prevent Mother-To-Child Transmission Of Hiv, John N. Williams

John N. WILLIAMS

Placebo-trials on HIV-infected pregnant women in developing countries like Thailand and Uganda have provoked recent controversy. Such experiments aim to find a treatment that will cut the rate of vertical transmission more efficiently than existing treatments like zidovudine. This scenario is first stated as generally as possible, before three ethical principles found in the Belmont Report, itself a sharpening of the Helsinki Declaration, are stated. These three principles are the Principle of Utility, the Principle of Autonomy and the Principle of Justice. These are taken as voices of moral imperative. But although each has intuitive appeal, it can be shown …

The Mozambique Eyecare Programme – A Partnership Which Addresses Avoidable Blindness In Lusophone Africa, Aoife Phelan, James Loughman, Eva Doyle

Conference Papers

According to the WHO about 831 million people are visually impaired worldwide, 45 million of them are blind. Most people with visual impairment are older, and females are more at risk at every age, in every part of the world. Uncorrected Refractive Error accounts for over half of all visual impairment. About 87% of the worlds visually impaired live in developing countries. The Mozambique Eyecare Programme (MEP) is a cross institutional collaboration between governments, higher education institutions, non-governmental organisations and corporations. The aims of this Programme are to collaborate to provide a sustainable solution to the problem of avoidable blindness …

Pegylated Interferon Α-2b Up-Regulates Specific Cd8+ T Cells In Patients With Chronic Hepatitis B, Ji Chen, Yan Wang, Jun Li, Feng-Qin Hou, Gui-Qiang Wang

Pharmacology and Toxicology Faculty Publications

AIM: To investigate the effect of pegylated interferon (IFN) α-2b on specific CD8+ T lymphocytes in patients with chronic hepatitis B (CHB). METHODS: Twenty-one patients with CHB were treated with pegylated IFN α-2b. Periphery blood mononuclear cells were isolated from fresh heparinized blood by Ficoll-Hypaque density gradient centrifugation (density: 1.077 g/L, Pharmingen) at weeks 0, 4, 8, 12, and 24, respectively. Frequency of circulating hepatitis B virus (HBV) epitope-specific CD8 T cells was detected by flow cytometry. Cytokines were detected by cytometric bead assay. RESULTS: The frequency of circulating HBV core or env-specific CD8 T cells was higher (P …

Stem Cells For Spinal Cord Regeneration: Current Status, Zain A. Sobani, Syed A. Quadri, Ather Enam

Section of Neurosurgery

Background: Nearly 11,000 cases of spinal cord injury (SCI) are reported in the United States annually. Current management options give a median survival time of 38 years, however, no rehabilitative measures are available. Stem cells have been under constant research given their ability to differentiate into neural cell lines replacing non functional tissue. Efforts have been made to establish new synapses and provide a conducive environment, by grafting cells from autologous and fetal sources, including embryonic or adult stem cells, Schwann cells, genetically modified fibroblasts, bone stromal cells, and olfactory ensheathing cells and combinations/ variants thereof.
Methods: In order to …

Analisis Ketahanan Hidup Lima Tahun Penderita Kanker Ovarium Epithelial Di Rumah Sakit Kanker Dharmais Jakarta, Indang Trihandini, Dieta Nurrika

Kesmas

Kanker ovarium merupakan salah satu penyebab utama kematian wanita. Dalam kasus kanker, jumlah serum albumin adalah indikator prognostik bertahan hidup yang penting, sementara probabilitas global pasien kanker ovarium dengan serum albumin ³ 3,6 g/dL dan ² 3,5 g/dL untuk bertahan hidup lima tahun masing-masing 23% and 10%. Namun di Indonesia, ketahanan hidup pasien-pasien kanker ovarium epithelial belum diteliti secara intensif. Penelitian yang dilaporkan ini bertujuan untuk menentukan probabilitas ketahanan hidup pasien-pasien kanker ovarium epithelial menurut tingkat serum albumin tertentu. Dengan menggunakan rancangan studi kohort retrospektif dan analisis ketahanan hidup, 48 orang pasien Rumah Sakit Kanker Dharmais Jakarta diamati sejak pertama …

Kualitas Hidup Anak Remaja Pada Keluarga Dengan Hiv/Aids Di Indonesia, Toha Muhaimin

Kesmas

Epidemi HIV/AIDS mempunyai dampak pada sosial ekonomi keluarga, terutama terhadap kualitas hidup anak remaja (12-18 tahun). Untuk melihat dampak HIV/AIDS dalam keluarga terhadap kualitas hidup remaja dan untuk mengidentifikasi berbagai faktor yang mempengaruhi besar dampak itu, telah dilakukan penelitian dengan menggunakan data survei tentang AIDS yang dikumpulkan tahun 2007 oleh Pusat Penelitian Kesehatan Universitas Indonesia. Variabel komposit yang terdiri variabel pendidikan, lingkungan sosial, dan aktivitas fisik, yang dikategorikan menjadi kurang baik dan baik, digunakan untuk mengukur kualitas hidup. Variabel-variabel ini kemudian dianalisis dengan regresi logistik untuk melihat besar dampak HIV/AIDS dalam keluarga, rumah tangga, dan anak terhadap kualitas hidup remaja. …

Kontaminasi Bakteri Escherichia Coli Pada Makanan Pedagang Kaki Lima Di Sepanjang Jalan Margonda Depok, Jawa Barat, Dewi Susanna, Yvonne M. Indrawani, Zakianis Zakianis

Kesmas

Menteri Kesehatan menetapkan bahwa makanan dan minuman tidak boleh mengandung bakteri Escherichia coli (E. coli). Namun, kebanyakan pemerintah daerah tidak menindaklanjutinya dengan menerapkan peraturan yang lebih teknis untuk mencegah penyakit-penyakit yang ditularkan lewat makanan. Penelitian ini bertujuan untuk mengukur kontaminasi E. coli dalam makanan yang dijual oleh pedagang kaki lima (PKL). Seratus PKL di sepanjang Jalan Margonda Kota Depok, Jawa Barat, dipilih secara acak sebagai sampel. Sebanyak 100 PKL, E. coli pada sampel berbagai jenis makanan diukur dengan metode most probable number, sementara sanitasi PKL dan kehigienisan penjamah makanan diamati. Ditemukan secara umum bahwa air bersih yang digunakan untuk memasak, …

Gangguan Akibat Kekurangan Yodium Pada Wanita Usia Subur Di Kecamatan Baturaden Kabupaten Banyumas, Jawa Tengah, Endo Dardjito, Setiyowati Rahardjo

Kesmas

Gangguan Akibat Kekurangan Yodium (GAKY) merupakan salah satu masalah gizi di Kabupaten Banyumas. GAKY disebabkan oleh defisiensi kronik asupan yodium, konsumsi goitrogenik, penggunaan kontrasepsi KB hormonal, faktor genetik, dan pengetahuan penderita. Prevalensi penyakit gondok di Kecamatan Baturaden, Kabupaten Banyumas, terus meningkat mencapai 35,38% pada tahun 2007 sehingga daerah ini tergolong endemis berat GAKY. Untuk menganalisis faktor-faktor risiko GAKY di Kecamatan Baturaden, suatu penelitian penjelasan dengan desain kasus kontrol telah dilakukan dengan melibatkan 30 orang wanita usia subur (15-45 tahun) yang menderita GAKY sebagai kasus dan 30 orang WUS lain yang tidak menderita GAKY sebagai sebagai kontrol. Kedua kelompok adalah penduduk …

The Best Christmas Gift Of All, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Cast-Saw Burns: Evaluation Of Skin, Cast, And Blade Temperatures Generated During Cast Removal, Franklin D. Shuler Md, Frank N. Grisafi

Orthopaedics

Background: The use of an oscillating saw for cast removal creates a potential for iatrogenic injury and patient discomfort. Burns and abrasions can occur from the heat created by frictional forces and direct blade contact. With use of a cadaver model system, skin temperature measurements were recorded during cast removal with an oscillating saw.

Methods: Casts of uniform thickness were applied to cadavers equilibrated to body temperature. The casts were removed by a single individual while simultaneously measuring temperatures at the skin-padding interface, cast-padding interface, and the blade. Variables tested include two removal techniques, two casting materials (fiberglass and plaster), …

Physician’S Ability To Manually Detect Isolated Elevation In Leg Intracompartmental Pressure., Franklin D. Shuler Md, Matthew J. Dietz

Orthopaedics

Background: Serial physical examination is recommended for patients for whom there is a high index of suspicion for compartment syndrome. This examination is more difficult when performed on an obtunded patient and relies on the sensitivity of manual palpation to detect compartment firmness—a direct manifestation of increased intracompartmental pressure. This study was performed to establish the sensitivity of manual palpation for detecting critical pressure elevations in the leg compartments most frequently involved in clinical compartment syndrome.

Methods: Reproducible, sustained elevation of intracompartmental pressure was established in fresh cadaver leg specimens. Pressures tested included 20 and 40 mm Hg (negative controls) …

Phosphorylation Meets Nuclear Import: A Review., Jonathan D Nardozzi, Kaylen Lott, Gino Cingolani

Department of Biochemistry and Molecular Biology Faculty Papers

Phosphorylation is the most common and pleiotropic modification in biology, which plays a vital role in regulating and finely tuning a multitude of biological pathways. Transport across the nuclear envelope is also an essential cellular function and is intimately linked to many degeneration processes that lead to disease. It is therefore not surprising that phosphorylation of cargos trafficking between the cytoplasm and nucleus is emerging as an important step to regulate nuclear availability, which directly affects gene expression, cell growth and proliferation. However, the literature on phosphorylation of nucleocytoplasmic trafficking cargos is often confusing. Phosphorylation, and its mirror process dephosphorylation, …

Mir-17* Suppresses Tumorigenicity Of Prostate Cancer By Inhibiting Mitochondrial Antioxidant Enzymes, Yong Xu, Fang Fang, Jiayou Zhang, Sajni Josson, William H. St. Clair, Daret K. St. Clair

Toxicology and Cancer Biology Faculty Publications

Aberrant micro RNA (miRNA) expression has been implicated in the pathogenesis of cancer. Recent studies have shown that the miR-17-92 cluster is overexpressed in many types of cancer. The oncogenic function of mature miRNAs encoded by the miR-17-92 cluster has been identified from the 5' arm of six precursors. However, the function of the miRNAs produced from the 3' arm of these precursors remains unknown. The present study demonstrates that miR-17* is able to suppress critical primary mitochondrial antioxidant enzymes, such as manganese superoxide dismutase (MnSOD), glutathione peroxidase-2 (GPX2) and thioredoxin reductase-2 (TrxR2). Transfection of miR-17* into prostate cancer PC-3 …

The Pseudomonas Aeruginosa Magnesium Transporter Mgte Inhibits Transcription Of The Type Iii Secretion System, Gregory G. Anderson, Timothy L. Yahr, Rustin R. Lovewell, George A. O'Toole

Dartmouth Scholarship

Pseudomonas aeruginosa is an opportunistic pathogen that causes life-long pneumonia in individuals with cystic fibrosis (CF). These long-term infections are maintained by bacterial biofilm formation in the CF lung. We have recently developed a model of P. aeruginosa biofilm formation on cultured CF airway epithelial cells. Using this model, we discovered that mutation of a putative magnesium transporter gene, called mgtE, led to increased cytotoxicity of P. aeruginosa toward epithelial cells. This altered toxicity appeared to be dependent upon expression of the type III secretion system (T3SS). In this study, we found that mutation of mgtE results in increased T3SS …

Self-Insurance And The Potential Effects Of Health Reform On The Small-Group Market, Kathryn Linehan

National Health Policy Forum

The Patient Protection and Affordable Care Act (PPACA) as amended by the Health Care Education Reconciliation Act of 2010 makes landmark changes to health insurance markets. Individual and small-group insurance plans and markets will see the biggest changes, but PPACA also affects large employer and self-insured plans by imposing rules for benefit design and health plan practices. Over half of workers—most often those in very large firms—are covered by self-insured health plans in which employers (or employee groups) bear all or some of the risk of providing insurance coverage to a defined population of workers and their dependents. As PPACA …

Formalizing A Conceptual Framework Of Work Domain Knowledge, Min Zhu

Dissertations & Theses (Open Access)

Background: The failure rate of health information systems is high, partially due to fragmented, incomplete, or incorrect identification and description of specific and critical domain requirements. In order to systematically transform the requirements of work into real information system, an explicit conceptual framework is essential to summarize the work requirements and guide system design. Recently, Butler, Zhang, and colleagues proposed a conceptual framework called Work Domain Ontology (WDO) to formally represent users’ work. This WDO approach has been successfully demonstrated in a real world design project on aircraft scheduling. However, as a top level conceptual framework, this WDO has not …