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Articles 961 - 990 of 76859
Full-Text Articles in Entire DC Network
Multiple Intracranial Aneurysms: An International Consensus Statement, Stavropoula Tjoumakaris
Multiple Intracranial Aneurysms: An International Consensus Statement, Stavropoula Tjoumakaris
Department of Neurosurgery Faculty Papers
Introduction: Multiple intracranial aneurysms (MIAs) pose diagnostic and therapeutic challenges, and widely used rupture-risk scores have not been validated for this subgroup. Research question: To develop expert-based recommendations for the diagnosis, rupture-risk assessment, treatment selection, and follow-up of patients with MIAs. Material and methods: A modified Delphi process was conducted. After topic generation from the literature, iterative questionnaires were administered anonymously online to invited experts. Consensus was prespecified as ≥70% agreement. Twenty-six of 35 invitees (74.3%) completed the survey. Results: Consensus identified the ruptured lesion in aneurysmal subarachnoid hemorrhage (aSAH) using computed tomographic angiography (CTA) and 3D rotational digital subtraction …
Golden Steps: A Dance-Based Program To Improve Balance In Older Adults — A Feasibility And Acceptability Study, Ramyr Bognot, Sophia Botelho, Nolan Caberto, Lauren Valerio, Joshua Yu, Jason Zeidman
Golden Steps: A Dance-Based Program To Improve Balance In Older Adults — A Feasibility And Acceptability Study, Ramyr Bognot, Sophia Botelho, Nolan Caberto, Lauren Valerio, Joshua Yu, Jason Zeidman
UNLV Theses, Dissertations, Professional Papers, and Capstones
Background
Falls are a leading cause of injury and loss of independence among older adults. Evidence-based programs such as Otago and Tai Ji Quan reduce fall risk, yet barriers to access and adherence remain. Dance-based interventions may offer a practical, enjoyable approach to engage older adults in balance training.
Purpose
This formative pilot study aimed to develop four dance routines grounded in evidence- based balance principles and evaluate their feasibility and acceptability among older adults, including factors influencing enjoyment and willingness to continue participation, to inform future clinical and community implementation.
Methods
Four routines (Polka, Country, Rockabilly, Salsa) were developed …
Effectiveness Of Cognitive Stimulation Therapy On The Quality Of Life Of Adults With Dementia: A Secondary Analysis, Evelyn Airam
Effectiveness Of Cognitive Stimulation Therapy On The Quality Of Life Of Adults With Dementia: A Secondary Analysis, Evelyn Airam
UNLV Theses, Dissertations, Professional Papers, and Capstones
This secondary analysis study evaluated the effectiveness of Cognitive Stimulation Therapy (CST) on quality of life (QoL), depressive symptoms, and cognitive function in 108 community-dwelling older adults with cognitive impairments, including dementia. Outcomes involved Quality of Life (QoL) measured by the Quality of Life in Alzheimer’s Disease (QoL-AD), symptoms of depression by the Cornell Scale for Depression in Dementia (CSDD), and cognitive function using the Saint Louis University Mental Status (SLUMS). After the CST, significant improvements were observed in QoL (p = .004), depressive symptoms (p = .002), and cognitive function (p < .001), with small effect sizes. Additionally, a significant interaction between sex and dementia diagnosis status was found in predicting cognitive changes, suggesting that the relationship between dementia diagnosis and cognitive improvement differs by sex. No between-group differences were found for QoL or depression. Findings support CST as a multidimensional, non-pharmacological intervention that improves cognitive, psychological, and social outcomes. Although effects were small, consistent improvements are clinically meaningful given the progressive nature of dementia. This study extends existing literature by demonstrating CST’s effectiveness in a community-based setting and reinforces its alignment with occupational therapy’s emphasis on participation and holistic care. Results highlight the need for early intervention and expanded access to CST programs to enhance quality of life in this population.
Correlation Between Maxillary Transverse Width, Alveolar Housing Width And Palatal Bone Thickness: A Cbct Retrospective Study, Eric G. Hollensbe
Correlation Between Maxillary Transverse Width, Alveolar Housing Width And Palatal Bone Thickness: A Cbct Retrospective Study, Eric G. Hollensbe
UNLV Theses, Dissertations, Professional Papers, and Capstones
Background:
Accurate assessment of transverse maxillary dimensions and surrounding bone morphology is critical for safe orthodontic treatment planning. Orthodontic expansion should remain within the biological limits of the alveolar housing and palatal bone to prevent adverse periodontal outcomes, including dehiscence, fenestration, and gingival recession. Standard diagnostic methods, such as dental casts and two-dimensional radiographs, offer limited information about the three-dimensional anatomy that restricts orthodontic tooth movement. Cone-beam computed tomography (CBCT) provides detailed evaluation of skeletal dimensions and cortical bone boundaries. This study aimed to examine the relationships among maxillary transverse width, alveolar housing thickness, and palatal thickness using CBCT imaging. …
Development And Evaluation Of A Training Program On Pain Assessments For Pediatric Care Teams In Skilled Nursing Facilities, Rudy Velasquez-Correa
Development And Evaluation Of A Training Program On Pain Assessments For Pediatric Care Teams In Skilled Nursing Facilities, Rudy Velasquez-Correa
UNLV Theses, Dissertations, Professional Papers, and Capstones
This capstone project was a program development and quality improvement initiative at Silver State Pediatrics focused on improving consistency and confidence of pediatric care staff in assessing and documenting pain in children, particularly those who are non-speaking and medically complex. Although validated tools such as the Face, Legs, Activity, Cry, Consolability (FLACC), revised-FLACC (R-FLACC), and Non-communicating Children’s Pain Checklist-Revised (NCCPC-R) exists, inconsistent training and limited interdisciplinary communication have led to variability in clinical practice. This project involved implementing a brief, 20-30-minute interdisciplinary training session for nursing and rehabilitation staff on the use of validated pediatric pain assessment tools and collaborative …
Exploring Bidirectionality In Global Health Partnerships: Perspectives From U.S. Pediatric Residency Programs., Anik Patel, Pauline Kamau, Justus Simba, Ashley Combs, Adelaide Barnes, Kathy Ferrer, Heather Haq, Duncan K. Hau, Lee Morris, Brittany Murray, Amy Rule, Reena P. Tam, Lisa Umphrey, Megan S. Mchenry
Exploring Bidirectionality In Global Health Partnerships: Perspectives From U.S. Pediatric Residency Programs., Anik Patel, Pauline Kamau, Justus Simba, Ashley Combs, Adelaide Barnes, Kathy Ferrer, Heather Haq, Duncan K. Hau, Lee Morris, Brittany Murray, Amy Rule, Reena P. Tam, Lisa Umphrey, Megan S. Mchenry
Manuscripts, Articles, Book Chapters and Other Papers
Introduction Despite growing interest, little guidance exists to re-evaluate global health partnerships (GHPs) through promoting bidirectionality. This study aims to understand the perspectives of United States (U.S.) pediatric global health (GH) faculty on institutional bidirectional practices to inform future discussions with international collaborators. Methods An internally, iteratively developed REDCap-based online survey (REDCap, Vanderbilt University, Nashville, TN), by our diverse author group, collected qualitative data from January 18 to February 20, 2023. Free-text responses were reviewed and coded inductively, with findings framed to generate themes for subsequent engagement with international partners. Results Of the 88 U.S. programs that identify as having …
Imaging Of The Centromedian Thalamic Nucleus Using 3d Fast Gray Matter Acquisition T1 Inversion Recovery Sequence In 3t Mri In Epilepsy, Tunchanok Paprad, Thanyachat Yutthakasaemsan, Supada Prakkamakul
Imaging Of The Centromedian Thalamic Nucleus Using 3d Fast Gray Matter Acquisition T1 Inversion Recovery Sequence In 3t Mri In Epilepsy, Tunchanok Paprad, Thanyachat Yutthakasaemsan, Supada Prakkamakul
Chulalongkorn Medical Journal
Background:
The centromedian thalamic nucleus (CM) is an emerging deep brain stimulation (DBS) target for neurological disorders, including drug-resistant epilepsy. Traditional DBS localization relies on predefined stereotactic coordinates, which may be imprecise. Novel MRI sequences enhance gray-white matter contrast, potentially allowing direct CM visualization, improving accuracy in DBS planning and targeting.
Objective:
This study evaluates the 3D Fast Gray Matter Acquisition T1 Inversion Recovery (FGATIR) MRI sequence for the visualization of the CM in epilepsy patients.
Methods:
This prospective IRB-approved descriptive study included adult epilepsy patients who underwent 3D FGATIR MRI sequence at 3 Tesla. Two neuroradiologists independently assessed CM …
The Association Between Sarcopenia And Functional Outcomes After Bipolar Hemiarthroplasty In Elderly Patients With Displaced Femoral Neck Fracture. Structural Equation Modeling., Sanzhar Artykbay, Stephen J. Kerr, Saran Tantavisut
The Association Between Sarcopenia And Functional Outcomes After Bipolar Hemiarthroplasty In Elderly Patients With Displaced Femoral Neck Fracture. Structural Equation Modeling., Sanzhar Artykbay, Stephen J. Kerr, Saran Tantavisut
Chulalongkorn Medical Journal
Background: Sarcopenia is an underrecognized condition that may impair recovery after hip fracture surgery in older adults.
Objectives: This study aimed to assess the impact of sarcopenia on functional outcomes and hip muscle strength in elderly individuals with femoral neck fractures while accounting for other potential confounding factors through a structural equation model (SEM).
Methods: Between January 2023 and October 2024, a prospective cohort study at a tertiary university hospital enrolled patients aged 60 and older undergoing bipolar hemiarthroplasty for displaced femoral neck fractures. Functional recovery was evaluated at 3-months follow-up using the Barthel Index (BI), Short Physical Performance Battery …
Clinical Outcomes Between Transradial And Transfemoral Primary Percutaneous Coronary Intervention In St-Segment Elevation Myocardial Infarction Patients In Chonburi Hospital: A Retrospective Study, Artit Torpongpun, Pornchai Ngamjanyaporn, Woravit Tantisiriwat, Chanadda Rutnuntamongkon, Gahn Nakornchai, Paramaporn Suttirut
Clinical Outcomes Between Transradial And Transfemoral Primary Percutaneous Coronary Intervention In St-Segment Elevation Myocardial Infarction Patients In Chonburi Hospital: A Retrospective Study, Artit Torpongpun, Pornchai Ngamjanyaporn, Woravit Tantisiriwat, Chanadda Rutnuntamongkon, Gahn Nakornchai, Paramaporn Suttirut
Chulalongkorn Medical Journal
Background: According to recent global data, transradial primary PCI in ST-elevation myocardial infarction (STEMI) patients has demonstrated better procedural outcomes compared to transfemoral PCI.
Objective: To compare the clinical outcomes between transradial and transfemoral primary PCI in STEMI patients at Chonburi Hospital.
Methods: Patients diagnosed with STEMI who underwent PCI at Chonburi Hospital between October 1, 2016, and September 30, 2023, were enrolled. Clinical data were obtained through a retrospective review of medical records and the Chonburi Hospital STEMI registry database.
Results:A total of 913 patients were eligible for statistical analysis, with 532 and 381 patients undergoing PCI via …
Factors Influencing Outcomes In Neonatal Abdominal Surgery: Surgeons’ Perspectives, Nimmita Srisan, Kanyarat Olarachin, Pattamon Sutthatarn, Katawaetee Decharun, Prapapan Rajatapiti, Somboon Reukvibunsi, Paisarn Vejchapipat
Factors Influencing Outcomes In Neonatal Abdominal Surgery: Surgeons’ Perspectives, Nimmita Srisan, Kanyarat Olarachin, Pattamon Sutthatarn, Katawaetee Decharun, Prapapan Rajatapiti, Somboon Reukvibunsi, Paisarn Vejchapipat
Chulalongkorn Medical Journal
Neonatal abdominal surgery was often indicated by congenital conditions, presenting significant risks of morbidity and mortality. However, comprehensive surgical data and identification of complication-related risk factors still receive little attention.
Purpose: Our objectives were to characterize neonatal patients undergoing abdominal surgery and to identify prognostic factors influencing complications and mortality in those patients.
Methods: A retrospective study was conducted on newborn patients aged between 0-30 days undergoing index surgery at a university hospital from 2013 to 2021. Categorical data were compared between the without-complication group and the with-complication group using the Chi-square tests and Fisher-Exact tests. Continuous data were analyzed …
Discharge Rates From Pediatric Emergency Departments Against Medical Advice Can Be Reduced By Improving Service Quality, Sounira Mehri, Josef Finsterer
Discharge Rates From Pediatric Emergency Departments Against Medical Advice Can Be Reduced By Improving Service Quality, Sounira Mehri, Josef Finsterer
Saudi Medical Journal
No abstract provided.
Integrating The Private Sector Into Surgical Residency Training: Insights From Dr. Sulaiman Al Habib Medical Group, Saudi Arabia, Nuha A. Alsaleh
Integrating The Private Sector Into Surgical Residency Training: Insights From Dr. Sulaiman Al Habib Medical Group, Saudi Arabia, Nuha A. Alsaleh
Saudi Medical Journal
No abstract provided.
Covid-19–Associated Rhabdomyolysis In Hospitalized Patients: Retrospective Cohort Study, Paula Esquerdo-Serrano, Silvia Otero-Rodriguez, Hector Pinargote-Celorio, Sergio Reus, Esperanza Merino, José-Manuel Ramos-Rincón
Covid-19–Associated Rhabdomyolysis In Hospitalized Patients: Retrospective Cohort Study, Paula Esquerdo-Serrano, Silvia Otero-Rodriguez, Hector Pinargote-Celorio, Sergio Reus, Esperanza Merino, José-Manuel Ramos-Rincón
Saudi Medical Journal
Objectives: To determine the frequency of rhabdomyolysis in patients hospitalized with COVID-19 and to characterize their clinical features and outcomes. Methods: All adults admitted to the hospital were included in this single-center retrospective cohort study with COVID-19 at a tertiary care institution in Alicante, Spain, between March 2020 and March 2024. A creatine kinase (CK) threshold of 1000 U/L or higher was used to define rhabdomyolysis. Demographic, clinical, laboratory, treatment, and outcome data were collected. Patients with and without rhabdomyolysis were compared, and factors associated with in-hospital mortality (IHM) were analyzed. Results: Among 7,590 hospitalized COVID-19 patients, 20 developed rhabdomyolyses …
Coronary Artery Ectasia: A 10-Year Experience At A Single Center In Saudi Arabia, Talal F. Aljabbary, Meshal S. Alhamed, Mohamed H. Ismaeel, Abdulrahman O. Alhaqbani, Abdullah S. Alhumimidi, Nouf A. Alanazi, Ayman M. Alsaleh, Khalid M. Aljohani, Waleed M. Alharbi, Mostafa Q. Alshamiri
Coronary Artery Ectasia: A 10-Year Experience At A Single Center In Saudi Arabia, Talal F. Aljabbary, Meshal S. Alhamed, Mohamed H. Ismaeel, Abdulrahman O. Alhaqbani, Abdullah S. Alhumimidi, Nouf A. Alanazi, Ayman M. Alsaleh, Khalid M. Aljohani, Waleed M. Alharbi, Mostafa Q. Alshamiri
Saudi Medical Journal
Objective: To assess the incidence of coronary artery ectasia (CAE) and its associated clinical characteristics and outcomes over a long follow-up period in Saudi Arabia. Methods: We retrospectively analyzed all coronary angiography procedures performed between January 2013 and June 2023. Patients with CAE were included in the final analysis. Results: During the 10-year period, 10,397 patients underwent coronary angiography. The CAE was diagnosed in 242 patients, yielding an incidence of 2.3%. The majority were male (92.6%). The average age was 57.15 ± 11.76 years. The right coronary artery (RCA) was the most involved vessel (65.2% of all patients). The most …
Tumor Markers And Pancreatic Enzymes Reflect Early Pancreatic Dysfunction In Type 2 Diabetes, Walaa Mohammedsaeed, Suliman Alharbi, Lama Alraddadi, Saja Aljohani, Talat Almehmadi, Sarah Alawfi
Tumor Markers And Pancreatic Enzymes Reflect Early Pancreatic Dysfunction In Type 2 Diabetes, Walaa Mohammedsaeed, Suliman Alharbi, Lama Alraddadi, Saja Aljohani, Talat Almehmadi, Sarah Alawfi
Saudi Medical Journal
Objective: To evaluate whether pancreatic enzymes and tumor markers reflect early pancreatic dysfunction in patients with type 2 diabetes mellitus (T2DM). Methods: In this cross-sectional study conducted between January 2023 and January 2024, 300 Saudi adults with T2DM were assessed for serum CA19-9, CA125, amylase, and lipase. Associations with glycemic control, insulin resistance (homeostatic model assessment for insulin resistance [HOMA-IR]), and metabolic parameters were examined using multivariable linear and logistic regression adjusted for age, sex, body mass index, diabetes duration, lipid profile, and medication use. Receiver-operating characteristic analyses evaluated biomarker performance for identifying poor glycemic control (HbA1c >8.5%). Exploratory analyses …
Male Pelvic Health In Saudi Arabia: Knowledge–Practice Gap In Pelvic Floor Muscle Exercises And Implications For Preventive Physiotherapy And Health Policy, Wael A. S. Alghamdi
Male Pelvic Health In Saudi Arabia: Knowledge–Practice Gap In Pelvic Floor Muscle Exercises And Implications For Preventive Physiotherapy And Health Policy, Wael A. S. Alghamdi
Saudi Medical Journal
No abstract provided.
Demographic Profiles, Clinical Characteristics, And Meteorological Context Of Heat-Related Illnesses Among Hajj Pilgrims In 2023, Ghadah Alsaleh, Majed Alsalamah, Fahad Alamri, Fatemah Alsaleh, Anas Khan
Demographic Profiles, Clinical Characteristics, And Meteorological Context Of Heat-Related Illnesses Among Hajj Pilgrims In 2023, Ghadah Alsaleh, Majed Alsalamah, Fahad Alamri, Fatemah Alsaleh, Anas Khan
Saudi Medical Journal
Objective: To describe the demographic profiles, clinical characteristics, and meteorological context of heat-related illnesses among Hajj pilgrims in 2023.
Methods: A retrospective cross-sectional study was conducted using data from 1,129 pilgrims diagnosed with HRIs across healthcare facilities in Mecca, Mina, and Arafat. Demographic and clinical data were extracted from the Hajj Health Information System, while temperature, humidity, wind speed, and rainfall records were obtained from the National Center for Meteorology.
Results: Heat exhaustion (48.2%) and heatstroke (37.4%) were the most common diagnoses, with 24.9% of the cases requiring hospitalization. Males represented 55.4% of cases and accounted for 51.2% of …
Obesity's Role In Stroke Incidence Among Smokers: An Assessment Of Confounding, Interaction, And Mediation Effects, Saeed Awad M. Alqahtani, Moutasem Salih Aboonq
Obesity's Role In Stroke Incidence Among Smokers: An Assessment Of Confounding, Interaction, And Mediation Effects, Saeed Awad M. Alqahtani, Moutasem Salih Aboonq
Saudi Medical Journal
Objectives: To examine the association between body mass index (BMI) category and history of stroke among current smokers, while assessing potential confounding, effect modification by age, and mediation by cardiovascular comorbidities. Methods: Data were analyzed from 53,939 current adult smokers participating in the 2021 Behavioral Risk Factor Surveillance System (BRFSS). Survey-weighted logistic regression estimated the association between BMI categories (underweight, normal, overweight, obese) and self-reported stroke history. The study assessed multicollinearity and adjusted for sociodemographic and health variables. Interaction terms were tested to evaluate effect modification by age, and exploratory decomposition analysis was used to assess mediation by conditions such …
Prevalence And Antimicrobial Susceptibility Patterns Of Nosocomial Bacteria Across Different Units At King Faisal Complex Hospital, Taif, Kingdom Of Saudi Arabia, Nahed Hawsawi, Renad N. Al-Jaiud, Layal L. Khyyat, Kholoud Alsulimany, Manhal Shabat
Prevalence And Antimicrobial Susceptibility Patterns Of Nosocomial Bacteria Across Different Units At King Faisal Complex Hospital, Taif, Kingdom Of Saudi Arabia, Nahed Hawsawi, Renad N. Al-Jaiud, Layal L. Khyyat, Kholoud Alsulimany, Manhal Shabat
Saudi Medical Journal
Objectives: Nosocomial infections significantly impact patient morbidity, mortality, and healthcare costs. To determine the prevalence, bacteriological profiles, antimicrobial susceptibility patterns, and resistance distribution of pathogens causing nosocomial infections at King Faisal Medical Complex, Taif, Kingdom of Saudi Arabia. Methods: This cross-sectional study was conducted between September 2023 and March 2024 at different hospital units following ethical approval. Samples (n = 667) were collected from patients (both genders; all ages) exhibiting infection symptoms ≥ 48 h post-admission and pre-antibiotic administration. Bacterial identification involved culture, Gram staining, and biochemical tests. Antimicrobial susceptibility was tested using the Phoenix100 system. Results: Of 667 patients, …
From Early Adversity To Adult Health: Quality-Of-Life Consequences In A Mental Illness In Saudi Arabia, Rawan Saad Alghamdi, Ahmad A. Mirza, Ibrahim Fae Asiri, Fatemah Samir Alghamdi, Nawaf Abdulaziz Alharthi, Shaymaa A. Abdalal, Iman K. Ramadan
From Early Adversity To Adult Health: Quality-Of-Life Consequences In A Mental Illness In Saudi Arabia, Rawan Saad Alghamdi, Ahmad A. Mirza, Ibrahim Fae Asiri, Fatemah Samir Alghamdi, Nawaf Abdulaziz Alharthi, Shaymaa A. Abdalal, Iman K. Ramadan
Saudi Medical Journal
Objectives: Childhood trauma (CT) is prevalent among bipolar disorder (BD) patients and exacerbates clinical outcomes, which may impact the quality of life (QoL). This study explores the prevalence of CT and its association with QoL among BD patients in Saudi Arabia. Methods: Cross-sectional study conducted among adults with BD during the euthymic phase. Sample size was estimated using a single-proportion approach (target n=141), and participants recruited by convenience sampling of eligible outpatients. CT was assessed using the Childhood Trauma Questionnaire (CTQ), and QoL using the the Brief Quality of Life in Bipolar Disorder (Brief QoL.BD). Results: The CT prevalence was …
Re-Emergence Of Pertussis In The Pediatric Population: A Tertiary Care Center's Experience, Haya S. Alshaibani, Tahir K. Hameed, Khaled H. Alsager, Mohammed A. Alshaalan, Syed F. Jamil
Re-Emergence Of Pertussis In The Pediatric Population: A Tertiary Care Center's Experience, Haya S. Alshaibani, Tahir K. Hameed, Khaled H. Alsager, Mohammed A. Alshaalan, Syed F. Jamil
Saudi Medical Journal
Objectives: To describe the 2024 surge in pertussis cases in the pediatric population in a large tertiary care center in Riyadh, Saudi Arabia. Methods: A retrospective observational study was conducted on children aged 0–14 years with PCR-confirmed Bordetella pertussis infection diagnosed at a tertiary hospital in Riyadh between January and December 2024. Patients older than 14 years, with negative or indeterminate PCR results, or diagnosed outside the study period were excluded, and demographic, immunization, clinical, and outcome data were analyzed. Results: A total of 36 children were diagnosed with pertussis, with 35 (97.2%) requiring hospital admission. The median age was …
A Retrospective Cohort Study Of Uterine Cancer Epidemiological Analysis And Age-Based Disparities In Saudi Arabian Population Across 32 Years, Sallwa M. Alshehre, Mohammad A. Althubiti
A Retrospective Cohort Study Of Uterine Cancer Epidemiological Analysis And Age-Based Disparities In Saudi Arabian Population Across 32 Years, Sallwa M. Alshehre, Mohammad A. Althubiti
Saudi Medical Journal
Objectives: To investigate the burden of uterine tumour in Saudi Arabia during the past 32 years (1990–2021), with an emphasize on the prevalence, incidence, mortality, and disability-adjusted life years (DALYs). Knowing these patterns strengthen the national aims of cancer control under Kingdom of Saudi Arabia (KSA) Vision 2030. Methods: A retrospective study was performed using data retrieved from the Global Burden of Disease (GBD) database. The work included population from Saudi Arabia between 1990 and 2021 and tested standardization age-specific metrics, involving uterine tumour incidence, prevalence, mortality, and DALYs. Results: Uterine tumour cases raised from 507 in 1990 to 6,366 …
Seroprevalence Of Hepatitis B And Hepatitis C In Patients Hospitalized In Palliative Care Service, Meryem Betos Koçak, Burcu Güler
Seroprevalence Of Hepatitis B And Hepatitis C In Patients Hospitalized In Palliative Care Service, Meryem Betos Koçak, Burcu Güler
Saudi Medical Journal
Objectives: Patients receiving palliative care often have complex comorbidities and frequent healthcare exposure, which may place them at risk for blood-borne infections such as hepatitis B virus (HBV) and hepatitis C virus (HCV). However, data on the seroprevalence and prognostic impact of these infections in palliative populations remain limited. This study aimed to determine the seroprevalence of HBV and HCV markers in patients hospitalized in a palliative care unit and to assess their association with mortality. Methods: This retrospective study conducted on 545 adult patients a tertiary palliative care unit between 2018 and 2024. Demographic characteristics, comorbidities, nutritional support, mobility, …
Artificial Intelligence In Dialysis Therapies: Applications In Hemodialysis And Peritoneal Dialysis For Managing Infectious Diseases And Complications, Waleed H. Mahallawi
Artificial Intelligence In Dialysis Therapies: Applications In Hemodialysis And Peritoneal Dialysis For Managing Infectious Diseases And Complications, Waleed H. Mahallawi
Saudi Medical Journal
This narrative review synthesizes evidence from a systematic literature search (2019–2025) on artificial intelligence (AI) applications in hemodialysis and peritoneal dialysis for managing infections and complications. Dialysis patients face infection rates 100-fold higher than the general population and sepsis mortality exceeding 35%. The AI, utilizing machine learning algorithms such as XGBoost, deep neural networks, and explainable AI tools, revolutionizes care through precise diagnostics, prognostics, and therapeutics. Key models demonstrate high accuracy in predicting bloodstream infections (area under the curve [AUC] 0.914), classifying peritonitis (F1 0.93), detecting SARS-CoV-2 (AUROC 0.82), and forecasting mortality (AUC 0.979). Therapeutically, AI guides antibiotic stewardship, reducing …
Post-Stroke Fatigue In Saudi Arabia: A Call To Action, Saad Z. Alqahtani
Post-Stroke Fatigue In Saudi Arabia: A Call To Action, Saad Z. Alqahtani
Saudi Medical Journal
Post-stroke fatigue (PSF) is a major consequence of stroke, with a prevalence of approximately 42–53% among stroke survivors. However, over the last 2 decades, only a few studies have explored PSF in Kingdom of Saudi Arabia (KSA). Findings from these studies show that PSF negatively impacts the quality of life of individuals with stroke. Furthermore, they emphasize the need for education for both health care providers and patients regarding PSF. This call-to-action mini narrative review identifies knowledge gaps and provides recommendations for both researchers and policymakers, including the need for standardized management and the exploration of hospital environment settings. Specifically, …
Contribution Of Interleukin-6 (Il-6) To Body Defense And Healing In Pulmonary Tuberculosis, Hasrah Junaidi, Annis C. Adi, Soedarsono Soedarsono, Soetjipto Soetjipto, Chatarina U. Wahyuni, Fariani Syahrul, Mahmudah Mahmudah, Zakiyuddin Zakiyuddin, Iskandar Arfan, Abdullah A. Mamun, Rubia Sari
Contribution Of Interleukin-6 (Il-6) To Body Defense And Healing In Pulmonary Tuberculosis, Hasrah Junaidi, Annis C. Adi, Soedarsono Soedarsono, Soetjipto Soetjipto, Chatarina U. Wahyuni, Fariani Syahrul, Mahmudah Mahmudah, Zakiyuddin Zakiyuddin, Iskandar Arfan, Abdullah A. Mamun, Rubia Sari
Saudi Medical Journal
Objective: To examine the contribution of IL-6 to host defense and healing in pulmonary tuberculosis (TB). Pulmonary tuberculosis continues to pose a significant global health challenge, with disease outcomes determined by complex host–pathogen interactions. Interleukin-6 (IL-6), a multifunctional cytokine, has been implicated in immune regulation and tissue recovery during TB, but its specific role is not fully established. This review aimed to examine the contribution of IL-6 to host defense and healing in pulmonary TB. Methods: A comprehensive literature search was performed across PubMed, Scopus, Web of Science, ScienceDirect, and Medline following PRISMA guidelines, covering publications from 2015 to 2025. …
Impact Of Treatment On The Health-Related Quality Of Life Of Children With Cancer In Saudi Arabia, Fayzah Hussain Alhussain, Amany Anwar Saeed Alabdullah
Impact Of Treatment On The Health-Related Quality Of Life Of Children With Cancer In Saudi Arabia, Fayzah Hussain Alhussain, Amany Anwar Saeed Alabdullah
Saudi Medical Journal
Objective: The impact of cancer on health-related quality of life (HRQOL) is considerable, particularly for children undergoing oncological treatment. While research has addressed HRQOL in childhood cancer survivors, less attention has been given to those actively undergoing treatment, including in Saudi Arabia. This systematic review aimed to address this gap by quantitatively evaluating studies reporting on the HRQOL of children in Saudi Arabia during their active cancer treatment phase. We also compare these findings with studies from around the world, emphasising demographic, medical and parental predictors of HRQOL. Methods: A comprehensive search of relevant databases (MEDLINE, CENTRAL, Embase, PsycINFO and …
Efficacy Of Continuous Pegcetacoplan Treatment For Subfoveal Geographic Atrophy In Age-Related Macular Degeneration: 36-Month Results From Oaks, Derby, And Gale Open-Label Extension, Dilsher S. Dhoot, Sunir J. Garg, David M. Brown, Ivan J. Suñer, Ehsan Rahimy, David S. Boyer, Kineta Naidu, Chao Li, Caroline R. Baumal, Robyn H. Guymer
Efficacy Of Continuous Pegcetacoplan Treatment For Subfoveal Geographic Atrophy In Age-Related Macular Degeneration: 36-Month Results From Oaks, Derby, And Gale Open-Label Extension, Dilsher S. Dhoot, Sunir J. Garg, David M. Brown, Ivan J. Suñer, Ehsan Rahimy, David S. Boyer, Kineta Naidu, Chao Li, Caroline R. Baumal, Robyn H. Guymer
Wills Eye Hospital Papers
PURPOSE: To report efficacy of intravitreal pegcetacoplan treatment over 36 months in eyes with subfoveal geographic atrophy (GA).
PATIENTS AND METHODS: The GALE (NCT04770545) open-label extension trial adds 12 months of results to the 24-month Phase 3 OAKS (NCT03525613) and DERBY (NCT03525600) trials, representing up to 36 months of continuous pegcetacoplan treatment. They included a heterogeneous population of eyes with subfoveal GA (63%). Pegcetacoplan-treated eyes enrolling in GALE continued at the same interval of pegcetacoplan monthly (PM) or every other month (PEOM). Patients' eyes in sham monthly or every-other-month arms crossed over to receive pegcetacoplan in GALE at the same …
Stimulant Medications And Bone Health, Christine M Swanson, Julie H Wolfe, Chadi A Calarge
Stimulant Medications And Bone Health, Christine M Swanson, Julie H Wolfe, Chadi A Calarge
Faculty, Staff and Students Publications
Purpose of review: This review summarizes the potential impact of stimulant medications on bone health, to raise awareness and optimize their safe use.
Recent findings: Stimulant medications can impair bone health through inadequate nutrient/calorie intake and stimulation of the sympathetic nervous system, which regulates bone metabolism. However, their use decreases fracture risk in younger populations ([Formula: see text]25 years old) with attention deficit/hyperactivity disorder (ADHD), likely through reductions in impulsivity and injury. Special care may be needed when fractures occur while using these medications, as recent data suggest psychostimulants are associated with impaired fracture healing. Prescription and non-prescription use of …
Cigarette And E-Cigarette Use In Greater Philadelphia: Proportion Of Use Compared To National Data And Local Predictors Of Smoking Status, Munjireen Sifat, Joshua Banks, Lilianna Phan, Kuang-Yi Wen, Julie A. Barta, Rebecca J. Melillo, Hee-Soon Juon
Cigarette And E-Cigarette Use In Greater Philadelphia: Proportion Of Use Compared To National Data And Local Predictors Of Smoking Status, Munjireen Sifat, Joshua Banks, Lilianna Phan, Kuang-Yi Wen, Julie A. Barta, Rebecca J. Melillo, Hee-Soon Juon
College of Population Health Faculty Papers
UNLABELLED: Objective tobacco use, cigarette, e-cigarette, cancer-related beliefs, perceived risk, lifestyle attribution, cancer disparities, health equity. We assessed cigarette smoking and e-cigarette use in the Greater Philadelphia region alongside national data. The objectives were to descriptively explore differences in tobacco use by sociodemographic characteristics. We also examined cancer belief associations with smoking and e-cigarette use in the local context.
METHODS: We descriptively compared cross-sectional survey data from 2744 adults in the Sidney Kimmel Comprehensive Cancer Center (SKCCC) catchment area (Greater Philadelphia region; May-July 2022) with 6252 Health Information National Trends Survey (HINTS 6) nationally representative respondents (United States; March-November 2022). …