Digital Commons Network^™

Prefabrication Of A Secondary Tram Flap., Geoffrey G. Hallock Md

Department of Surgery

A secondary TRAM flap was prefabricated in a rat model using the rectus muscle. The right rectus muscle was elevated as an inferiorly pedicled muscle flap in one experimental group (n = 6) and as a superiorly pedicled muscle flap in a second group (n = 5) and then sandwiched between a silicone sheet and the abdominal skin. Two weeks later, the abdominal skin and attached rectus muscle were elevated over the silicone sheet as a secondary TRAM flap. The surviving skin paddle areas of these prefabricated TRAM flaps were compared with superiorly (n = 7) and inferiorly (n = …

Complications, Untoward Events, And Reality., Geoffrey G. Hallock Md

Department of Surgery

The only surgeons who do not have deal with complications are those who do not operate.1

Churg-Strauss Syndrome With Intestinal Perforation, Javaid A. Khan, Imran Hassan, Shahid Pervez, Wasim Jafri, Shaista Khan

Department of Pathology and Laboratory Medicine

No abstract provided.

Integrated Multimedia Timeline Of Medical Images And Data For Thoracic Oncology Patients, Denise R. Aberle, John David N. Dionisio, Michael F. Mcnitt-Gray, Ricky K. Taira, Alfonso F. Cárdenas, Jonathan G. Goldin, Kathleen Brown, Robert A. Figlin, Wesley W. Chu

Computer Science Faculty Works

A prototype multimedia medical database has been developed to provide image and textual data for thoracic oncology patients undergoing treatment of advanced malignancies. The database integrates image data from the hospital pieture archiving and communication system with textual reports from the radiology information system, alphanumeric data contained in the hospital information system, and other electronic medical data. The database presents information in a timeline format and also contains visualization programs that permit the user to view and annotate radiographic measurements in tabular or graphic form. The database provides an efficient and intuitive display of the changing status of oncology patients. …

Removal Of Extracellular Chloride Suppresses Transmitter Release From Photoreceptor Terminals In The Mudpuppy Retina., Wallace B. Thoreson, R . F. Miller

Journal Articles: Ophthalmology

Removal of extracellular Cl- has been shown to suppress light-evoked voltage responses of ON bipolar and horizontal cells, but not photoreceptors or OFF bipolar cells, in the amphibian retina. A substantial amount of experimental evidence has demonstrated that the photoreceptor transmitter, L-glutamate, activates cation, not Cl-, channels in these cells. The mechanism for Cl-free effects was therefore reexamined in a superfused retinal slice preparation from the mudpuppy (Necturus maculosus) using whole-cell voltage and current clamp techniques. In a Cl-free medium, light-evoked currents were maintained in rod and cone photoreceptors but suppressed in horizontal, ON bipolar, and OFF bipolar cells. Changes …

A Polymorphism Of A Platelet Glycoprotein Receptor As An Inherited Risk Factor For Coronary Thrombosis., Ethan J. Weiss, Paul F. Bray, Matthew Tayback, Steven P. Schulman, Thomas S. Kickler, Lewis C. Becker, James L. Weiss, Gary Gerstenblith, Pascal J. Goldschmidt-Clermont

Cardeza Foundation for Hematologic Research

BACKGROUND: Platelet glycoprotein IIb/IIIa is a membrane receptor for fibrinogen and von Willebrand factor, and it has an important role in platelet aggregation. It is known to be involved in the pathogenesis of acute coronary syndromes. Previously, we found a high frequency of a particular polymorphism, PlA2, of the gene encoding glycoprotein IIIa in kindreds with a high prevalence of premature myocardial infarction.

METHODS: To investigate the relation between the PlA2 polymorphism and acute coronary syndromes, we conducted a case-control study of 71 case patients with myocardial infarction or unstable angina and 68 inpatient controls without known heart disease. The …

University Of New England Board Of Trustees: President Sandra Featherman Inauguration Program 1996-4-2, University Of New England

William Kirmes, D.O. Collection

Program for the inauguration of University of New England President Sandra Featherman, April 2, 1996.

Endobronchial Tuberculosis--Manifesting By Coughing Up Of Bronchial Cartilage, A M. Memon, A Shafi, H Thawerani

Section of Pulmonary & Critical Care

No abstract provided.

Vital Signs, Spring 1996, Boonshoft School Of Medicine

Vital Signs

A twenty four page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

Toxoplasma Gondii-Induced Immune Suppression By Human Peripheral Blood Monocytes: Role Of Gamma Interferon., Jacqueline Y. Channon, Lloyd H. Kasper

Dartmouth Scholarship

The ability of Toxoplasma gondii to evade the host immune response during primary infection in humans is poorly understood. In murine toxoplasmosis, infected spleen macrophages release soluble factors that mediate a transient immunosuppression, which may allow the parasite to become established. When an enriched population of human monocytes from seronegative individuals was incubated with toxoplasmas in vitro, soluble factors that mediated market suppression of mitogen-induced lymphocyte DNA synthesis were released. Irradiated tachyzoites that do not undergo replication were sufficient stimuli for near-maximal soluble factor release. Up to 50% of the soluble factor-mediated suppression is attributable to a gamma interferon (IFN-gamma)-dependent …

Digest Of The Philadelphia College Of Osteopathic Medicine (Spring 1996), Philadelphia College Of Osteopathic Medicine

Digest

The Spring 1996 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• President’s Perspective
• Primary Care Research
• College Board Profile
• PCOM Students Show their Diversity
• Alumni Board Profile
• Capital Campaign Developments
• Spring Convention Highlights
• Class Acts
• PCOM Merchandise
• Coming Events

A Validation Of Target Heartrate Formulas Used In Swimming, Tasha Kay Litwinski

Masters Theses

The purpose of this study was to explore whether procedures used to establish target heart rates (THRs) for running are applicable to front crawl swimming. Eight male and 22 female fitness swimmers from Western Michigan University participated in this study. Their exercise durations under three experimental conditions were compared. The conditions were: (a) Condition 1, a treadmill run at an intensity equal to a THR of 85% of heart rate reserve (HRR); (b) Condition 2, a front crawl swim at an intensity equal to 85% of HRR; and (c) Condition 3, a front crawl swim at an intensity equal to …

Identification Of A Brazil-Nut Allergen In Transgenic Soybeans, Julie A. Nordlee, Steve L. Taylor, Jeffrey A. Townsend, Laurie A. Thomas, Robert K. Bush

Department of Food Science and Technology: Faculty Publications

Background: The nutritional quality of soybeans (Glycine max) is compromised by a relative deficiency of methionine in the protein fraction of the seeds. To improve the nutritional quality, methionine-rich 2S albumin from the Brazil nut (Bertholletia excelsa) has been introduced into transgenic soybeans. Since the Brazil nut is a known allergenic food, we assessed the allergenicity of the 2S albumin.

Methods: The ability of proteins in transgenic and nontransgenic soybeans, Brazil nuts, and purified 2S albumin to bind to IgE in serum from subjects allergic to Brazil nuts was determined by radioallergosorbent tests (four …

The Extranasal Glioma - A Cause Of Neonatal Respiratory Distress, Muneer Amanullah, F Attar Z

Department of Surgery Docs

Normal brain tissue in an abnonnal configuration, occurring at a site away from the cranial cavity, is temied an Extranasal Glioma. Since its first description in 1852 by Reid², only 140 patients with this entity have been reported. Heterotopic brain tissue when present in a confined area may cause obstmction, pressure and pain. Its occurrence in the nasopharyngeal region is relatively rare and only 19 cases have been reported so far², the majority presenting with respiratory distress in the early neonatal period. The objective of this report is to create an awareness amongst the physicians of …

Nefom: Board Of Trustees: Kirmes To Lenz 1996-2-9, William Kirmes D.O.

William Kirmes, D.O. Collection

A letter from Dr. Kirmes to Dr. Craig Lenz regarding the future of NEFOM.

Ms211: News Clips, Armin Weinberg

Works on Radiation Effects: 1990-2020

A collection of news clips I used to track what might be relevant to our work in Kazakhstan. Of note is a story about Newmont Corp's interest in developing gold resources in the region. They eventually were contacted and help support several public health education initiatives in the Semey region. See more at Armin Weinberg, PhD Papers and its finding aid.

University Of New England Board Of Trustees: Alfond Center Postcard, University Of New England

William Kirmes, D.O. Collection

A postcard thanking the recipient for contributing to the fundraising for the Alfond Center for Health Sciences.

University Of New England Board Of Trustees: President Sandra Featherman Inauguration Invitation, University Of New England

William Kirmes, D.O. Collection

Invitation to the inauguration of University of New England President Sandra Featherman, April 2, 1996.

Adverse Cerebral Outcomes After Coronary Bypass Surgery, Gary W. Roach , M.D., Marc Kanchuger , M.D., Christina Mora Mangano , M.D., Mark Newman , M.D., Nancy Nussmeier , M.D., Richard Wolman , M.D., Anil Aggarwal , M.D., Katherine Marschall , M.D., Steven H. Graham , M.D., Ph.D., Catherine Ley , Ph.D., Gerard Ozanne , M.D., Dennis T. Mangano , Ph.D., M.D., Ahvie Herskowitz , M.D., Vera Katseva , Ph.D, Rita Sears , R.N., M.S.

Anesthesiology Publications

ABSTRACT

Background Acute changes in cerebral function after elective coronary bypass surgery are a difficult clinical problem. We carried out a multicenter study to determine the incidence and predictors of — and the use of resources associated with — perioperative adverse neurologic events, including cerebral injury.

Methods In a prospective study, we evaluated 2108 patients from 24 U.S. institutions for two general categories of neurologic outcome: type I (focal injury, or stupor or coma at discharge) and type II (deterioration in intellectual function, memory deficit, or seizures).

Results Adverse cerebral outcomes occurred in 129 patients (6.1 percent). A total of …

Decreases In Ovarian Cytochrome P450c17 Alpha Activity And Serum Free Testosterone After Reduction Of Insulin Secretion In Polycystic Ovary Syndrome, John E. Nestler , M.D., Daniela J. Jakubowicz , M.D.

Obstetrics and Gynecology Publications

BACKGROUND

Insulin resistance and increased ovarian cytochrome P450c17α activity are both features of the polycystic ovary syndrome. P450c17α, which is involved in androgen biosynthesis, has both 17α-hydroxylase and 17,20-lyase activities. Increased activity of this enzyme results in exaggerated conversion of progesterone to 17α-hydroxyprogesterone in response to stimulation by gonadotropin. We hypothesized that hyperinsulinemia stimulates ovarian P450c17α activity.

METHODS

We measured serum steroid concentrations during fasting and the response of serum 17α-hydroxyprogesterone to leuprolide, a gonadotropin-releasing hormone agonist, and performed oral glucose-tolerance tests before and after oral administration of either metformin (500 mg three times daily) or placebo for four to …

Time Course Of Recruitment, Pit Formation And Apoptosis Of Osteoclast Populations On Dentin In Vitro, Jihyun Kang, Rigoberto Cornejo, Kevin J. Hirokawa, Susan M. Digiorgio, Darlene F. Howard, Susan F. Silverton

Cells and Materials

The resorptive capacity of osteoclasts in vitro has been used as an indicator of bone resorption. However, the kinetics of osteoclast development and senescence is not well understood. It has been noted that mononuclear precursors migrate to calcified substrate and after multi-nucleation become competent bone resorbing cells. Osteoclasts, once finished a wave of resorption, become senescent. In order to determine the survival characteristics of osteoclast populations involved in calcified tissue destruction, we have investigated the time course of the recruitment to dentin and apoptosis of osteoclasts. We have established the linkage between these measurements and the time course of the …

Periodic Lateralized Epileptiform Discharges, Nathan Watemberg , M.D., Lawrence D. Morton , M.D.

Neurology Publications

No abstract provided.

Biofilm Mediated Calculus Formation In The Urinary Tract, Robert J. C. Mclean, David J. Stickler, J. Curtis Nickel

Cells and Materials

Mineralization and subsequent calculus formation is a common complication of biofilm infections. In the urinary tract, these infected calculi often arise from infections by urease-producing bacteria. Ammonia, liberated by bacterial urease activity, increases urine pH, resulting in the precipitation of Ca and Mg as carbonateapatite {Ca₁₀(PO₄,CO₃)₆(OH,CO₃)₂} and struvite (NH₄MgP0₄·6H₂O). These minerals become entrapped in the organic matrix which surrounds the infecting organisms and ultimately grow into mature calculi. When the causative organisms grow on urinary catheters and stents, the resulting mineralization can …

Perturbations Of Periosteel Bone During Healing: Effect Of Non-Weight Bearing, Helen E. Gruber, Mary E. Kirchen, John R. Sweeney, William E. Anderson, G. June Marshall

Cells and Materials

Weight bearing (WB) is an important factor influencing bone remodelling. The present study evaluates the effects of weight bearing and non-weight bearing (S) (achieved by tail suspension and hindlimb elevation) on the healing of a fibular osteotomy in adult male rats. After 9, 18 or 36 days under WB or S conditions, periosteum near the callus formed at the osteotomy site was compared to periosteum of the contralateral fibula (which did not receive an osteotomy) or to periosteum of fibula of control animals which did not receive an osteotomy. Data show that periosteal bone healing is sensitive to alterations in …

Validation Of Energy Dispersive X-Ray Spectrometry As A Method To Standardize Backscattered Electron Images Of Bone, E. G. Vajda, R. D. Bloebaum, J. G. Skedros

Cells and Materials

The use of backscattered electron (BSE) imaging as a tool for the qualitative measurement of mineral content in bone has been well documented. The challenge still remains to develop BSE imaging as a tool for quantitative mineral content analysis in bone. The limiting factor has been the ability to standardize the BSE signal within and between laboratories. Energy dispersive x-ray spectrometry (EDX) has been proposed as a method to standardize the BSE operating environment. The goal of this study is to investigate the relationship between EDX-determined wt.% Ca measurements and BSE graylevels. A comparison with traditional ash content measurements will …

Ua35/11 Student Honors Research Bulletin, Wku Honors Program

WKU Administration Documents

The WKU Student Honors Research Bulletin is dedicated to scholarly involvement and student research. These papers are representative of work done by students from throughout the university.

• Brooks, Lynnette and Cindy Calisi. The Effect of Selenium Supplementation on the Immune Response of Mice with Experimental Chagas' Disease
• Hildreth, John. Teasing the Muse
• Jenkins, Rhonda. Steinbeck's Portraits of Prostitutes: Progression of an Author's Vision
• Kirkham, Michelle. The Prenatal Use of Crack Cocaine: How It Affects Children and How Schools Can Respond
• Gibson, Jeanette and Juli McCay. Circadian Rhythm of Brain GABA Levels in the Cockroach, Leucophaea Maderae
• Patterson, Dana. Home Schooling …

Preventing Perinatal Transmission Of Hiv Costs And Effectiveness Of A Recommended Intervention, Robin D. Gorsky, P G. Farnham, Walter L. Straus, Blake Caldwell, D R. Holtgrave, R. J. Simonds, M F. Rogers, Mary Guinan

School of Public Health Faculty Research

In the United States, nearly all new human immunodeficiency virus (HIV) infections in children are acquired through perinatal (mother-to-infant) transmission. Each year, approximately 7000 infants are born to HIV-infected women in the United States.¹ Without intervention, an estimated 15-30% of these infants would become infected.² In 1994, results of the AIDS Clinical Trial Group (ACTG) Protocol 076 showed that treatment of infected pregnant women and their infants with zidovudine (ZDV) reduced the rate of perinatal HIV transmission from 25% to 8%.^3,4 Following these findings, the Public Health Service (PHS) issued recommendations for ZDV therapy to prevent perinatal …

Analysis Of The Effects Of Overexpression Of Metallothionein-I In Transgenic Mice On The Reproductive Toxicology Of Cadmium., T Dalton, Kai Fu, G C Enders, R D Palmiter, G K Andrews

Journal Articles: Pathology and Microbiology

Exposure to low levels of cadmium reduces fertility. In male mice spermatogenesis is highly sensitive to cadmium, whereas in females the peri-implantation period of pregnancy is sensitive. To examine the potential roles of the cadmium-binding protein, metallothionein (MT), in the reproductive toxicology of cadmium, we examined a transgenic mouse strain that overexpresses metallothionein-I (MT-I). These mice had dramatically increased steady-state levels of MT-I mRNA and MT in the testes and in the female reproductive tract during the peri-implantation period of pregnancy, and this overexpression occurred in a cell-specific and temporally regulated manner similar to that of the endogenous MT-I gene. …

Health Professions Division Academic Year 1996-1997, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Uwomj Volume 66, No 1, Winter 1996-97, Western University

University of Western Ontario Medical Journal

An interdisciplinary medical science publication, established in 1930.