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Chlamydia Trachomatis Infection In The Female Reproductive Tract Of The Rat: Influence Of Progesterone On Infectivity And Immune Response, Charu Kaushic, Andrew D. Murdin, Brian J. Underdown, Charles R. Wira

Dartmouth Scholarship

As the most common cause of sexually transmitted disease in women, chlamydial infections can lead to pelvic inflammatory disease, infertility, and ectopic pregnancy. To better understand the role played by sex hormones in modulating the immune response of the genital tract to microbial infections, we have developed a rat model to study Chlamydia trachomatis infection. Inbred female Lewis rats were primed with progesterone and inoculated by intrauterine instillation of C. trachomatis (mouse pneumonitis strain MoPn) into each uterine horn. When infected animals were examined for the presence of chlamydial antigens 14 days postinfection, both the uterus and vagina were found …

Predicting Prognosis In Lung Cancer: Use Of Proliferation Marker, Ki67 Monoclonal Antibody, I N. Soomro, J Holmes, W F. Whimster

Department of Pathology and Laboratory Medicine

An investigation was carried out to assess the prognostic significance of proliferation marker Ki67 in a group of lung cancer patients treated by surgery (limited disease). Tissue was not available for Ki67 immunostaining in inoperable group. The diagnosis is established by bronchial biopsy which does not carry enough tissue for frozen section and counting. This study is supplemented by estimating the prognostic significance of histological sub-types in the operable group and in a group of inoperable patients with extensive disease. These are usually treated by radiotherapy and/or chemotherapy. In all, 267 patients were studied including 105 treated by surgery. These …

Oncolog, Volume 43, Number 02, February 1998, Beth W. Allen, Alison Ruffin, Rebecca D. Pentz Ph.D.

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Genetic findings prompt cancer survivor to elect surgery
• Protocols: Radiotherapy Protocols Offer Treatment for Range of Sites and Types of Cancer
• Radiation oncology: targeting effective treatment
• House Call: Cancer: Is it in the Genes or in the Stars?
• DiaLog: Genetic Tests Demand New Answers by Rebecca D. Pentz, PhD, Clinical Ethicist

A Comparison Of Severe Pre-Eclampsia/Eclampsia In Patients With And Without Hellp Syndrome, N F. Zuberi, K Arif, F M. Khan, J A. Pal

Department of Obstetrics & Gynaecology

Background: The relationship of Haemolysis, Elevated Liver Enzymes and Low Platelets (HELLP) syndrome with maternal and perinatal health and its presentation in Pakistani population is not known.
Purpose: To determine the mode of presentation along with maternal and perinatal outcome of patients with HELLP syndrome.
Methods: Case records of patients with severe hypertension in pregnancy who delivered between January 1, 1989 and December 31, 1994 at The Aga Khan University Hospital, Karachi. Out of 120 cases of severe pre-eclampsia/eclampsia, there were 36 cases of HELLP syndrome (Group-A). These were then compared with cases without HELLP syndrome (Group B) for their …

Effects Of First And Second Trimester Vaginal Bleeding On Pregnancy Outcome, S A. Karim, I Bakhtawar, A T. Butta, M Jalil

Department of Obstetrics & Gynaecology

The effects of vaginal bleeding during first and second trimester on pregnancy outcomes was assessed in a hospital-based population of 268 non-diabetic women. The group of non-bleeders comprised 173 females whereas, there were 71 females with first and 24 with second trimester bleeding. Fetal loss (abortion) occurred in 34% of first trimester and 25% of second trimester bleeders. Low birth weight and preterm delivery were significantly associated with second trimester haemorrhage. The results suggest that first and second trimester vaginal bleeding correlates with adverse infant outcomes.

Investigation Of The Roles Of Toxin-Coregulated Pili And Mannose-Sensitive Hemagglutinin Pili In The Pathogenesis Of Vibrio Cholerae O139 Infection, Carol O. Tacket, Ronald K. Taylor, Genevieve Losonsky, Yu Lim

Dartmouth Scholarship

In this study, adult volunteers were fed tcpA and mshA deletion mutants of V. cholerae O139 strain CVD 112 to determine the role of toxin-coregulated pili (TCP) and mannose-sensitive hemagglutinin (MSHA) in intestinal colonization. Eight of 10 volunteers who received CVD 112 or CVD 112 ΔmshA shed the vaccine strains in their stools; the geometric mean peak excretion for both groups was 1.4 × 10⁵ CFU/g of stool. In contrast, only one of nine recipients of CVD 112 ΔtcpA shed vibrios in his stool (P < 0.01); during the first 24 h after inoculation, 3 × 10² CFU/g was recovered from this volunteer. All recipients of CVD …

Dna Methylation And Carcinogenesis In Digestive, Javed Yakoob, Fan Xue-Gong, Hu Guo-Ling, Zhang Zheng

Section of Gastroenterology

No abstract provided.

Medical Education Digest, Vol. 1 No. 1 (January 15, 1998), Nova Southeastern University

Medical Education Digest

No abstract provided.

Ms211: Letter To Kazakh Ambassador To The Us, Armin Weinberg

Works on Radiation Effects: 1990-2020

A letter to Bolat K. Nurgaliyev the Kazakhstan Ambassador to the US regarding an upcoming meeting we helped orchestrate that included AFRRI. Also an interesting reference to Mr. James Giffin regarding the committee for reorganization of the health care system in the Republic of Kazakhstan that I was asked to comment on. Turns out Giffin was later arrested and charged related to bribes in a scandal known as Kazahkgate. See more at Armin Weinberg, PhD Papers and its finding aid.

Effects Of Metformin On Spontaneous And Clomiphene-Induced Ovulation In The Polycystic Ovary Syndrome, John E. Nestler , M.D., Daniela J. Jakubowicz , M.D., William S. Evans , M.D., Renato Pasquali , M.D.

Obstetrics and Gynecology Publications

ABSTRACT

Background Obese women with the polycystic ovary syndrome are relatively unresponsive to the induction of ovulation by clomiphene. We hypothesized that reducing insulin secretion by administering metformin would increase the ovulatory response to clomiphene.

Methods We performed oral glucose-tolerance tests before and after the administration of 500 mg of metformin or placebo three times daily for 35 days in 61 obese women with the polycystic ovary syndrome. Women who did not ovulate spontaneously were then given 50 mg of clomiphene daily for five days while continuing to take metformin or placebo. Serum progesterone was measured on days 14, 28, …

Preventing The Unnecessary Losses Of Alzheimer's Disease, Lin E. Noyes

Case Studies from Age in Action

Educational Objectives

1. To state the importance of early detection and diagnosis of Alzheimer's disease.

2. To describe common concerns of people in the early stages of Alzheimer's disease.

3. To describe interventions to help people who have recently been diagnosed with Alzheimer's disease or other dementias.

Reducing Medication Mismanagement In Adult Care Residences, Mary Ann F. Kirkpatrick

Case Studies from Age in Action

Educational Objectives

1. Describe the prevalence of medication mismanagement in adult care facilities in Virginia.

2. Explain the significance of selected medication management errors.

3. Recommend practices to improve medication management task performance in adult care facilities.

State Regulation Of Assisted Living Facilities, Sonya A. Sterbenz

Case Studies from Age in Action

Educational Objectives

1. To define the role of assisted living facilities in the continuum of long-term care options for older adults.

2. To present the various arguments concerning the regulation of the assisted living industry.

Medications And Falls, Patricia W. Slattum

Case Studies from Age in Action

Educational Objectives:

1. To describe potential causes of falls and ways to prevent them.

2. To illustrate how medications can contribute to an increased risk of falls and recommend strategies for reducing this risk.

Voices From The Floor - A Pcom Anthology (Winter 1998), Pcom

Voices from the Floor

The Winter 1998 issue includes:

• "One Day at at Time with Michael" by Mary DeJoseph, DO and Paul DeJoseph, DO,
• "The Bloodless Medical Care Option" by Ronald C. Morgan
• "Going Home" by By Maria J. Hoertz, MPH, MSIII
• "The Humors in Uniform" by Susan Entwistle Marshall, MSII

Reflections: Historical Perspectives On Pathology In Houston And Galveston, Ellen B. Koch

Texas Medical History E-Books

“This account of pathology in the Houston and Galveston area … examines important themes in the development of pathology in this area, using selected details from the careers of individuals and institutions to illustrate how pathologists, as practitioners, teachers, and researchers, dealt with the challenges they faced in finding and keeping a niche for pathology in the medical world.” - Preface

This book was written to commemorate the 50^th anniversary of Houston Society of Clinical Pathologists. Bibliographic references and other resources are included.

A Comparison Of Rectal Diazepam Gel And Placebo For Acute Repetitive Seizures, Fritz E. Dreifuss , M.D., N. Paul Rosman , M.D., James C. Cloyd , Pharm.D., John M. Pellock , M.D., Ruben I. Kuzniecky , M.D., Warren D. Lo , M.D., Fumisuke Matsuo , M.D., Gregory B. Sharp , M.D., Joan A. Conry , M.D., Donna C. Bergen , M.D., Walter E. Bell , Ph.D

Neurology Publications

ABSTRACT

Background Acute repetitive seizures are readily recognizable episodes involving increased seizure frequency. Urgent treatment is often required. Rectal diazepam gel is a promising therapy.

Methods We conducted a randomized, doubleblind, parallel-group, placebo-controlled study of home-based treatment for acute repetitive seizures. Patients were randomly assigned to receive either rectal diazepam gel, at doses ranging from 0.2 to 0.5 mg per kilogram of body weight on the basis of age, or placebo. Children received one dose at the onset of acute repetitive seizures and a second dose four hours later. Adults received three doses — one dose at onset, and two …

Repair Of The Airway Epithelium: Potential Opportunities For Therapeutic Intervention In Airway Disease, Stephen I. Rennard

Journal Articles: Pulmonary & Critical Care Med

The epithelium of the airway has considerable capacity to undergo repair. These repair processes are responsible for maintaining and restoring function after injury of the airways, which likely occurs often as a result of infectious, toxic or other exposures. However, repair processes need not be fully effective. Inadequate repair can take a number of forms and may result in metaplasia, hyperplasia or fibrotic scarring. It is likely that repair processes that lead to tissue disruption play an important role in the chronic airways diseases, such as asthma and bronchitis. Through delineation of these processes, it may become feasible to target …

Health Professions Division Catalog Academic Year 1998-1999, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Acquired Arterio-Venous Fistula With Mycetoma: Two Entities Coinciding: A Case Report, Saldar Nasim Khan, Nabil Wasif, Masood Umar, Mohamrnad Umar

Section of Orthopaedic Surgery

No abstract provided.

Patient Dumping: Implications For The Elderly, George P. Smith Ii

Scholarly Articles

Before 1986, the Common Law provided that physicians and hospitals had no duty to admit or treat persons who sought their care except in limited circumstances. Congress enacted The Emergency Medical Treatment and Active Labor Act (EMTALA) to curb this so-called patient-dumping problem. EMTALA provides, essentially, that Medicare-participating hospitals must treat all patients who arrive in emergency conditions.

This article first discusses the patient-dumping problem and how EMTALA has provoked many hospitals to curtail their emergency facilities in order to avoid treating indigent and uninsured patients. The Article then proceeds to analyze the specifics of EMTALA’s main statutory provision, Section …

Clear Cell Sarcoma Of The Kidney And Congenital Mesoblastic Nephroma: Cellular And Molecular Characterization Of Primary Tumors, Tumor Cell Lines, And Nude Mouse Xenografts Delineate Wilms' Tumor-Distinct Histopathogenetic Properties, Noel Anderson Brownlee

MUSC Theses and Dissertations

Clear cell sarcoma of the kidney (CCSK) and Congenital mesoblastic nephroma (CMN) are both pediatric renal tumors that differ from Wilms' tumor based on their distinctive histopathologic characteristics and clinical behavior. CCSK is a very malignant tumor characterized by a propensity for bone metastases, contrasting the relatively benign course characteristic of the majority of Wilms' tumors. CMN, in contrast, is a tumor of the newborn usually diagnosed within the first three months of life that is generally cured with surgery alone. To investigate further the cellular and molecular relationships of CCSK, CMN, and Wilms' tumor, a nude mouse xenograft and …

Experiencing Physical Violence During Pregnancy: Prevalence And Correlates, Vilma E. Cokkinides, Ann L. Coker

CRVAW Faculty Journal Articles

Violence during pregnancy directly impacts the mental and physical health of pregnant women. We assessed the prevalence and correlates of physical violence around the time of pregnancy in a representative sample of 6,718 women in South Carolina. Physical violence, defined as "being physically hurt by husband or partner" or "being involved in a physical fight" was reported by 10.9% of recently pregnant women. These were correlates of violence: experiencing increased numbers of stressful life events, being unmarried, having increased parity, being on Medicaid, and having an unwanted pregnancy. Screening to identify violence in pregnancy in health care settings is vital …

Immunopathogenesis Of A Spectrum Of Inflammatory Lung Diseases Induced By Experimental Reovirus Infection, Stephen Clifford Bellum

MUSC Theses and Dissertations

Inflammatory lung diseases cause a significant amount of morbidity and mortality. However, the mechanisms that control the initiation and resolution of pulmonary inflammatory responses have not been well-elucidated. Histopathological data suggests that the lung responds with a similar pattern of inflammation to diverse range of injurious stimuli. In order to investigate the immunopathogenesis of lung inflammation, a series of in vivo models of lung inflammation were generated in CBA/J and CD-I mice by respiratory reovirus 1/L infection. Using this approach, it was observed in CBA/J mice that a relatively low titer of reovirus 1/L induced a pattern of intraluminal fibrosis …

Evaluation Of The Role Of Fructosamine As An Indicator Of Diabetic Control, Katherine Hooley

Theses

Diabetes mellitus, a common metabolic disease, is characterised by excess circulating glucose concentrations. Such a hyperglycaemic status provides the stimulus for irreversible glycation (non-enzymatically post-translational) of structural and functional proteins. Protein glycation, although a cause of complication (neuropathy, micro/macrovascular disease), provides a time-averaged index of diabetes status and control. In particular, glycated plasma proteins analysis, i.e., the fructosamine assay, has received favourable response due to its speed, simplicity, low cost, and ease of automation. However, lack of standardisation and a universally-accepted calibrant has limited technical and subsequent clinical confidence in fructosamine analysis. In response, a comprehensive technical evaluation (including novel …

Percutaneous Nephrostomy: A Non-Operative Management Of Urinomas: 2 Case Reports, Tanveer-Ul-Haq, I H. Rizvi, Z A. Khan, A A. Khan

Department of Radiology

No abstract provided.

Reply, Y A. Husen, M U. Islam, I H. Rizvi

Department of Radiology

No abstract provided.

Ectopic Placement Of Central Venous Catheter, Importance Of X-Ray Chest, Nadeem A. Zaidi, Fazal Hameed Khan

Department of Anaesthesia

A case of malpositioning of central venous catheter which was judged to be correctly placed on clinical criteria isbeing presented. Abberant positioning was picked up on X-ray

Oncolog, Volume 43, Number 01, January 1998, Sunita Patterson, Stephanie Deming, Therese Bevers Md

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Taking Mammography on the Road
• Reassurance and Education Foster Rehabilitation After Colorectal Surgery
• Protocols: Protocols focus on chemoprevention, improving preoperative radiotherapy, and treating advance-stage colorectal cancer
• Sphincter-Preserving Surgery Improves Outcome for Patients with Rectal Cancer
• House Call: Stopping Cancer Before It Occurs: Spell P-r-e-v-e-n-t-i-o-n
• Dialog: Reaching Out and In by Therese Bevers, MD, Cancer Prevention Center Director
• Protocols: Protocols focus on chemoprevention, improving preoperative radiotherapy, and treating advance-stage colorectal cancer

Digest Of The Philadelphia College Of Osteopathic Medicine (Winter 1998), Philadelphia College Of Osteopathic Medicine

Digest

The Winter 1998 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Opening Remarks
• PCOM Updates
• Our Centennial
• Founders Day '98
• A Doctor's Helping Hand
• PCOM Honors Domenic A. Debias, Phd
• The Physician Assistant
• Mission Milestones
• Profiles
• Convention Highlights
• Class Notes
• Just Published
• In Memoriam
• Coming Events