Digital Commons Network^™

Medical Education Digest, Vol. 2 No. 3 (June 15, 2000), Nova Southeastern University

Medical Education Digest

No abstract provided.

Differential Involvement Of Na(+),K(+)-Atpase Isozymes In Preimplantation Development Of The Mouse., D J Macphee, D H Jones, K J Barr, D H Betts, A J Watson, G M Kidder

Obstetrics & Gynaecology Publications

Na(+),K(+)-ATPase plays an essential role in mammalian blastocoel formation (cavitation) by driving trans-epithelial sodium transport. Previously, the alpha1 and beta1 subunit isoforms of this enzyme were identified in preimplantation mouse embryos and were assumed to be responsible for this function. Here we show that mRNAs encoding an additional alpha subunit isoform (alpha3) and the remaining two beta subunit isoforms are also present in preimplantation embryos. Whereas alpha3 mRNA accumulates between the four-cell and the blastocyst stages and thus results from embryonic transcription, the same could not be demonstrated for beta2 and beta3 mRNAs. Immunoblot analyses confirmed that these subunits are …

Commencement, Philadelphia (2000), Philadelphia College Of Osteopathic Medicine

Commencements

Philadelphia Campus D.O. Commencement Program, 109th Class. Degrees include Doctor of Osteopathic Medicine.

Commencement Speaker: Donna E. Shalala, Secretary, U.S. Department of Health and Human Services

Com Outlook June 2000, College Of Osteopathic Medicine

COM Outlook

No abstract provided.

Tibial Plateau Fractures: A New Classification Scheme, Raja Muhammad Shahzad Khan, Shuja Hassan Khan, Agha Jamil Ahmad, Muhammad Umar

Section of Orthopaedic Surgery

Fractures of the tibial plateaus are common injuries. Various classification schemes have been used to describe these injuries. Although each system has its own purpose, the simpler systems do not allow comparison with more complex divisions. The problem is compounded by the variable use of adjectives that describe these fractures. A comprehensive classification of tibial plateau fractures should group fractures that are similar in topography, morphology, and pathogenesis, requiring similar treatment, and having a similar prognosis. Fracture dislocations and standard tibial plateau fractures should be incorporated into a single classification to avoid the use of two complementary classifications. Any such …

Angiotensin Ii Promotes Atherosclerotic Lesions And Aneurysms In Apolipoprotein E-Deficient Mice, Alan Daugherty, Michael W. Manning, Lisa A. Cassis

Gill Heart & Vascular Institute Faculty Publications

Increased plasma concentrations of angiotension II (Ang II) have been implicated in atherogenesis. To examine this relationship directly, we infused Ang II or vehicle for 1 month via osmotic minipumps into mature apoE^–/– mice. These doses of Ang II did not alter arterial blood pressure, body weight, serum cholesterol concentrations, or distribution of lipoprotein cholesterol. However, Ang II infusions promoted an increased severity of aortic atherosclerotic lesions. These Ang II–induced lesions were predominantly lipid-laden macrophages and lymphocytes; moreover, Ang II promoted a marked increase in the number of macrophages present in the adventitial tissue underlying lesions. Unexpectedly, pronounced abdominal …

Cerebellopontine Angle Medulloblastoma, Naim-Ur-Rahman, A Jamjoom, M Al-Rayess, Z A. Jamjoom

Section of Neurosurgery

No abstract provided.

Oncolog, Volume 45, Number 06, June 2000, Kerry L. Wright, Margaret E. Goode, Jack Roth Md, Gary S. Clayman Md, Dds

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Newly Organized Ophthalmology Section Expands Treatment of Ocular Malignancies
• Turning Knowledge Into Effective Gene Therapies, by Jack A. Roth, MD, Professor, Department of Thoracic and Cardiovascular Surgery, and Gary S. Clayman, MD, DDS, Associate Professor, Head and Neck Surgery
• Microarrays Reduce Time, Labor, and Cost of DNA Analysis
• New DNA Microarray Technology Could Speed Up Discovery of the Genetic Causes of Lung Cancer
• House Call: Virtual Health: Finding Reliable Medical Resources on the Internet
• Clinical Practice Guidelines: Case Report: Ovarian Cancer
• Protocols: Studies Aim to Detect and Treat Ocular Malignancies

Locus Of Control, Coping, And Anticipatory Nausea In Women With Breast Cancer, Melinda L. Nielsen

Loma Linda University Electronic Theses, Dissertations & Projects

Many cancer patients experience adverse chemotherapy-related side effects. The present study examined whether the perception that one can control and effectively cope with her treatment for breast cancer mitigate against any nausea and vomiting that she may experience in anticipation of chemotherapy treatments. Seventy-five women with breast cancer completed the Multidimensional Health Locus of Control Scale - Form C, the Krantz Health Opinion Survey, the Ways of Coping Scale - Revised, and the Morrow Assessment of Nausea and Emesis. As hypothesized, internal health locus of control was significantly positively related to positive reappraisal coping strategies. This relationship was moderated by …

Pilomatrixoma And Pilomatrix Carcinoma Deceptively Similar But Distinct Entities, T S. Khan, A Khan

Department of Surgery Docs

No abstract provided.

Association Of Epstein Barr Virus (Ebv) With Nasopharyngeal Carcinoma (Npc), S H. Shah, I N. Soomro, S Haroon, T Moatter

Department of Pathology and Laboratory Medicine

Aim:
To observe the frequency of nasopharyngeal carcinoma (NPC) and its association with Epstein Barr Virus (EBV) infection.
Setting:
This study included consecutive cases of nasopharyngeal carcinoma, which were diagnosed in the Department of Pathology at the Aga Khan University Hospital, Karachi in the period of two years (1996-97).
Methods:
These tumors were initially evaluated on H&E stained sections. The tumors showing evidence of keratinization were excluded from the study. The Epstein Barr Virus was detected with the help of Polymerase chain reaction in formalin fixed, paraffin embedded tissue sections.
Results:
During the study period, seventeen cases of nasopharyngeal carcinoma …

Audit Of Lymph Node Biopsies In Suspected Cases Of Lymphoproliferative Malignancies: Implications On Tissue Diagnosis And Patient Management, Mohammad Zeeshan Qamar, Mehrukh Mujib, Shahid Pervez

Department of Pathology and Laboratory Medicine

Aims: To carry out an audit ascertaining the importance of condition of lymph node specimen, submission of clinical history including site of biopsy and imrnunohistochemcial studies on conclusiveness of diagnosis made.

Methodology: Computer records of the Aga Khan University Hospital, Histopathology Laboratory were used to analyze all cases of lymphoproliferative malignancies presented at the hospital from 1992 to 1998.

Results: Out of a total of 466 cases studied, in 283 (61%) the lymph nodes were fragmented. The site of biopsy was mentioned in 361 (77.5%) cases with the cervical region forming the most common site (56.5%). A clinical history was …

Incidence And Pattern Of Thrombocy To Penia In Cardiac Surgery Patients, S Bashir, S M. Shah, I Babar

Department of Anaesthesia

No abstract provided.

Evaluating The Sensitivity Of The Nanostrong Ncounter® Analysis System To Determine Gene Expression Changes Associated With Chemotherapy Treatment, Katerina Dukleska, Md, Christopher W. Schultz, Bs, Mahsa Zarei, Phd, David Mckeown, Md, Charles J. Yeo, Md, Jonathan Brody, Phd, Jordan M. Winter, Md

Department of Surgery Posters

Introduction

• Pancreatic ductal adenocarcinoma (PDA) remains a deadly disease with a 5-year survival of 8% for all stages combined (Siegel RL et al.). Currently, it’s the third leading cause of cancer-related deaths in the United States and by 2020 it is projected to become the second leading cause (Rahib L, et al).
• The poor prognosis in PDA is in part due to the limited therapies that are currently available.
• This highlights the importance of high-throughput technologies for gene expression analyses and drug screens.
• A recently developed NanoString Technologies nCounter® analysis system, an example of high-throughput technology, utilizes a color-coded barcode …

Effect Of Receptor-Selective Retinoids On Growth And Differentiation Pathways In Mouse Melanoma Cells, Sejal H. Desai, Goran Boskovic, Linda L. Eastham, Marcia Dawson, Richard M. Niles

Biochemistry and Microbiology

Treatment of B16 mouse melanoma cells with all-trans-retinoic acid (ATRA) results in inhibition of cell proliferation and induction of differentiation. Accompanying these events is an induction of retinoic acid receptor β (RARβ) expression, an increase in protein kinase Cα (PKCα) expression, and enhanced activator protein-1 (AP-1) transcriptional activity. These cells express nuclear RARα and RARγ and nuclear retinoid X receptors (RXR) α and β constitutively. We tested the ability of receptor-selective retinoids to induce the biochemical changes found in ATRA-treated melanoma cells and also tested their effectiveness in decreasing anchorage-dependent and -independent growth. The RXR-selective ligand (2E,4E)-6-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)-3,7-dimethyl-2,4,6-octatrienoic acid (SR11246) was …

Regulation Of Acetylated Low Density Lipoprotein Uptake In Macrophages By Pertussis Toxin-Sensitive G Proteins, Stewart C. Whitman, Alan Daugherty, Steven R. Post

Gill Heart & Vascular Institute Faculty Publications

Class A scavenger receptors (SR-A) mediate the uptake of modified low density lipoprotein (LDL) by macrophages. Although not typically associated with the activation of intracellular signaling cascades, results with peritoneal macrophages indicate that the SR-A ligand acetylated LDL (AcLDL) promotes activation of cytosolic kinases and phospholipases. These signaling responses were blocked by the treatment of cells with pertussis toxin (PTX) indicating that SR-A activates G_i/o-linked signaling pathways. The functional significance of SR-A-mediated G_i/o activation is not clear. In this study, we investigated the potential role of G_i/o activation in regulating SR-A-mediated lipoprotein uptake. Treatment of mouse …

Electrically Mediated Plasmid Dna Delivery To Hepatocellular Carcinomas In Vivo, L. Heller, M. J. Jaroszeski, D. Coppola, C. Pottinger, R. Gilbert, Richard Heller

Bioelectrics Publications

Gene therapy by direct delivery of plasmid DNA has several advantages over viral gene transfer, but plasmid delivery is less efficient. In vivo electroporation has been used to enhance delivery of chemotherapeutic agents to tumors in both animal and human studies. Recently, this delivery technique has been extended to large molecules such as plasmid DNA. Here, the successful delivery of plasmids encoding reporter genes to rat hepatocellular carcinomas by in vivo electroporation is demonstrated.

Oncolog, Volume 45, Number 05, May 2000, Kerry L. Wright, Stephanie Deming, Gordon B. Mills Md, Phd

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Early Detection of Melanoma Spread May Increase Survival Benefits of Adjuvant Therapy
• No Easy Answers: Women at Increased Risk for Breast Cancer Face Difficult Choices
• DiaLog: Understanding Risk: A Prerequisite for Making Informed Decisions, by Gordon B. Mills, MD, PhD, Chairman, Department of Molecular Therapeutics
• House Call: Looking for Trouble: How to Spot Signs of Melanoma
• Protocols: Melanoma Clinical Trials
• Biochemotherapy Means Hope for Patients with Advanced Melanoma

Central Nervous System Lymphomas: A Histologic And Immunophenotypic Analysis, Suhail Muzaffar, M. Shahid Siddiqui, Irshad Nabi Soomro, Shahid Pervez, Naila Kayani Naila Kayani, Sheema H. Hasan Sheema H. Hasan Sheema H. Hasan, Lmran Siddiqui Lmran Siddiqui

Department of Pathology and Laboratory Medicine

Objective: To observe the spectrum of non-Hodkin’s lymphomas involving the central nervous system including morphological subtypes and immunophenotypic status.

Setting: Retrospective analysis of eleven years (1986 to 1996) data from surgical pathology files of Department of Pathology.

Results: orty-three cases of non-Hodgkin’s lymphomas were diagnosed during the period of eleven years (from 1986 to 1996), all of which were diffuse types. A total of 1177 Central Nervous CNS biopsies were examined, out of which 937 cases were diagnosed as CNS neoplasms, the remaining were non-neoplastic in nature. Among 937 CNS neoplasms, 43 cases (4.6%) were reported as non-Hodgkin’s lymphomas. As …

Effects Of High Fruit Intake On Systematic Blood Pressure In African Americans, Leonard L. Gibbons

Loma Linda University Electronic Theses, Dissertations & Projects

This randomized dietary intervention trial examined the effects of a high fruit diet on systemic BP in African-Americans. Thirty-eight free-living subjects with systolic BPs between 130-159 mm Hg and diastolic BPs between 85-99 mm Hg, were enrolled for a six week period. The cases were given daily supplements of potassium rich foods: bananas, orange juice and raisins, while no dietary advice or food was given to the controls.

After six weeks, the means systolic BP was 5.79 mm Hg ( p=.009) lower in the cases than the controls. The mean diastolic BP at week six was 3.76 mm Hg (p=.047) …

The Relationship Between Health Attitudes, Beliefs, Health Locus Of Control And Use Of Breast Cancer Screening Modalities In Elderly Hispanic Women, Debra Kay Gillett, Rosamaria Ortiz

Theses and Dissertations - UTB/UTPA

A non-experimental design was used to examine the relationship between health attitudes, beliefs, locus of control and the use of breast cancer screening modalities in elderly Hispanic women in this pilot study. Leininger's Theory of Culture Care Diversity and Universality and the Health Belief Model were the supporting theoretical frameworks. Research was conducted at the Amigos del Valle senior centers in Hidalgo County and included 52 English-speaking elderly Hispanic volunteer participants. Instruments used for data collection were the Health Care Attitudes and Beliefs Scale and the Multidimensional Health Locus of Control Scale. Results of this study revealed that there appears …

Means To Achieve Sustained Release Of Synergistic Drugs By Conjugation, Paul Ashton, Peter A. Crooks, Tadeusz Cynkowski, Grazyna Cynkowska, Hone Guo

Ophthalmology and Visual Science Faculty Patents

A codrug composition of at least two drug compounds covalently linked to one another via a labile bond to form a single codrug composition, or ionically linked to one another to form a single workings composition, and methods of use of the codrug for the treatment of various medical conditions. The codrug may be administered by itself or in the form of a bioerodible or nonbioerodible substance.

Medical Education Digest, Vol. 2 No. 2 (April 15, 2000), Nova Southeastern University

Medical Education Digest

No abstract provided.

The Next Step, Benjamin Y. Dai, Lynn Thompson, John David N. Dionisio, Hooshang Kangarloo, Ricky K. Taira

Computer Science Faculty Works

In traditional radiology practice, reports are typically dictated and then transcribed.? While the free-text reports represent the semantic knowledge interpreted and conveyed by a physician, the information can be hard to access. The advantages of representing medical data in a structured format using standard terminology are clearly recognized. These include the ability to implement a standardized electronic medical record, automatically invoke medical guidelines when appropriate, and conduct outcomes research. Standard structured reports facilitate intelligent indexing, searching, and retrieval of documents from clinical databases. Recent attempts have been made in the industry to enable structured data entry using preformatted templates, but …

Is Incapacity A Permanent Thing?, Shirley M. Neitch

Internal Medicine

No abstract provided.

Com Outlook April 2000, College Of Osteopathic Medicine

COM Outlook

No abstract provided.

Differential Expression Of Chemokines In A Mouse Model Of Wound Healing, Susan H. Jackman, Matthew B. Yoak, Shivaleela Keerthy, Bonnie L. Beaver

Biochemistry and Microbiology

Macrophages have a multifaceted role in wound healing. While their initial activity may be in the degradation and elimination of damaged tissue, macrophages also produce and secrete a variety of mediators that can participate in the repair process as well. To perform these functions, macrophages must be recruited to a wound site. Our purpose was to examine the temporal and spatial expression of macrophage chemoattracting cytokines (chemokines) at a surgical wound site. A surgical wound was prepared on the dorsal aspect of B6AFI/J mice. Biopsies were obtained from the wound and a comparable nonwounded area between 6 and 72 hr …

Dietary Fish Oil Sensitizes A549 Lung Xenografts To Doxorubicin Chemotherapy, W. Elaine Hardman, Mary Pat Moyer, Ivan L. Cameron

Biochemistry and Microbiology

A549 xenografts were allowed to grow in nude mice to about 5 mm in diameter, then diets were changed to modified AIN-76 diets containing 19% wt/wt. fish oil (FO) or 20% wt./wt. com oil (CO). Ten days later dietary ferric citrate (0.3% wt./dry wt.) was added and doxoribicin (DOX) treatment (3.6 mg/kg i.v. each of the 5 days for 18 days) commenced. Treatment with DOX halted the growth of tumors in the CO fed mice. However, in those mice, which consumed FO or FO with ferric citrate, treatment with DOX caused significant tumor regression.

Vital Signs, Spring 2000, Boonshoft School Of Medicine

Vital Signs

A twenty four page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

Oncolog, Volume 45, Number 04, April 2000, Don Norwood, Kerry L. Wright, Ellen R. Gritz Phd, Alexander V. Prokhorov Md, Phd

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Rise in Incidence, Associated Diseases Complicate Screening for Esophageal Cancer
• DiaLog: Preventing Cancers of the Upper Aerodigestive Trad: Challenges for Clinicians, by Ellen R. Gritz, PhD, Professor and Chair, Department of Behavioral Science, and Alexander V. Prokhorov, MD, PhD, Assistant Professor, Department of Behavioral Science
• House Call: Gene Therapy: Changing the Way Cancer Cells Behave
• Efforts in Thyroid Cancer Treatment Include Initiation of Multicenter Clinical Trials
• Preclinical Studies Examine Strategies to Fight Rare Forms of Thyroid Cancer
• Protocols: Clinical Trials for Esophageal Cancer