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Hypoxanthine-Induced Differentiation Of Cultured Human Leukemia Cells, Gayle Jennette Singleton

Chemistry & Biochemistry Theses & Dissertations

Human cultured leukemia cells appear to have a decreased amount of inosine in their tRNA. When cells with inosine deficient tRNA are placed in a hypoxanthine fortified media, they incorporate hypoxanthine into their tRNA by the action of the enzyme tRNA-hypoxanthine ribosyl transferase. This generates the nucleoside inosine in the tRNA. The cultured human leukemia cell lines, CCRF-CEM, HL-60, and HGPRT(-) HL- 60, incorporate hypoxanthine into their tRNA, as determined by tRNA isolation, hydrolysis, and HPLC analysis. Hypoxanthine treatment dramatically inhibited cell growth in conjunction with partial induction of differentiation in the CCRF-CEM, HL-60, and HGPRT ( - ) HL-60 …

Improvement In Left Ventricular Systolic Function After Pericardiocentesis: Case Report, Gary S. Salem, Robert A. Genovese, Mohsin Alam, Mihai Gheorghiade

Henry Ford Hospital Medical Journal

No abstract provided.

Screening For Adenocarcinoma Of The Prostate, Brian J. Miles

Henry Ford Hospital Medical Journal

No abstract provided.

Primary Fibrinolysis In Acute Monocytic Leukemia, Ellis J. Van Slyck, Sundara B. K. Raman, Nalini Janakiraman

Henry Ford Hospital Medical Journal

We present the case of a young man with acute monocytic leukemia (French-American-British classification:M5) and systemic hyperfibrinolysis with severe bleeding. Although fibrinolysis is usually mild and secorulary to disseminated intravascular coagulation, its role as a primary and dominant factor in rare cases of leukemia warrants that its presence be sought as a cause of abnormal bleeding. Decreased serum plasminogen and increased serum plasmin determined by synthetic substrate assay and a negative protamine paracoagulation test are crucial findings. Use of high-dose epsilon-aminocaproic acid was effective in treating this complication. A transient increase in fibrinolytic activity coincident with the early effect of …

Pleural Effusion In Michigan Caused By Coccidioides Immitis After Travel To An Endemic Area, Christopher M. Hughes, Paul A. Kvale

Henry Ford Hospital Medical Journal

Primary coccidioidal disease is rarely diagnosed in the midwest in the nonimmunocompromised host. Since coast-to-coast travel is common today, many patients may become exposed to Coccidioides immitis while traveling in endemic areas. We present a case of acute coccidioidal pleural effusion in a Michigan woman who had recently visited northeastern Arizona. Her travel history was the single most important factor in the eventual diagnosis of coccidioidal pleural effusion.

Histopathologic Diagnosis And Classification Of Prostate Adenocarcinoma: Biologic Significance, Jill M. Peters, John D. Crissman

Henry Ford Hospital Medical Journal

Early diagnosis and accurate, biologically meaningful classification of prostate neoplasia remain important goals. The relation of evolving clinicopathologic concepts of histologic appearances to potential tumor progression is a major advance in classification of prostatic neoplasia. The criteria for recognizing incidental or "occult" stage A-l adenocarcinomas remain problematic in diagnosis, and focal neoplasms with little or no propensity to progression must be differentiated from cancers with a high likelihood of aggressive behavior. Current histologic grading systems in classifying prostate adenocarcinoma accurately identify two cancer subsets: 1) focal well differentiated tumors which rarely progress, and 2) diffuse poorly differentiated tumors which invariably …

Echo-Doppler Features Of Pulmonary Valve Endocarditis, Jihad Bitar, Mohsin Alam

Henry Ford Hospital Medical Journal

Three patients with fever and pneumonitis were found to have pulmonary valve vegetations by echocardiography. Pulsed and color flow Doppler studies demonstrated mild to moderate pulmonary valve insufficiency in these patients. All patients responded to the appropriate antibiotics without requiring valve surgery. Echocardiography is of value in diagnosing pulmonary valve endocarditis and should be considered in every patient with recurrent pneumonitis.

Digitalis Intoxication Or Intrinsic Conduction System Disease, Hooman Mahdyoon, Howard S. Rosman, Demetrios N. Mermiges, Mihai Gheorghiade

Henry Ford Hospital Medical Journal

No abstract provided.

Cerebral Infarction Associated With Cocaine Use, Iliana Meza, Carlos A. Estrada, Justo A. Montalvo, Walter N. Hidalgo, Jennie Andresen

Henry Ford Hospital Medical Journal

We report the case of a young man with an acute infarction of the left putamen and caudate nucleus, whose symptoms appeared six hours after intranasal use of approximately 0.5 g of cocaine hydrochloride. It seems probable that in this patient cocaine consumption played a role in the development of stroke.

Southeastern University Of Health Sciences Catalog 1989-1991, Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Design And Implementation Of A Sports Medicine Clinic With Emphasis On The High School Student-Athlete, Christopher Allen Mumaw

Theses Digitization Project

No abstract provided.

Oncolog, Volume 34, Number 03, July-September 1989, Stephen L. Huber Ms, Nicky Dozier Pharmd, Naguib A. Samaan Md, Phd

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Understanding Dose Intensity is Essential for Optimizing Chemotherapeutic Regimens
• Dysplastic Nevus Syndrome Identifies Patients at High Risk for Melanoma
• Multiple Endocrine Neoplasia Syndromes

Digest Of The Philadelphia College Of Osteopathic Medicine (Winter 1989), Philadelphia College Of Osteopathic Medicine

Digest

The Winter 1989 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• President's Perspective
• New Appointments & Promotions
• A Profile of Courage and Loyalty
• Recent Improvements Upgrade - Hospital Operations
• The Family Greer
• On Campus
• The Long Distance Diagnosis
• Class Acts
• In Memorium
• Calendar

Urinary Tract Infection, B J Farooqui, Mehboob Alam, Mohammad Khurshid

Department of Pathology and Laboratory Medicine

Over two years, 9892 mid-stream urine samples from patients attending the Aga Khan University Hospital, Karachi were cultured. Significant bacterial growth was seen in 23.5% samples. Further iden­tification of these organisms Eevealed 40% of E.coli, 16% Pseudomonas aeruginosa, 11% Klebsiella aerogenes, 5.0% Enterobacter sp., 13% Protdus sp., 4.0% Serratia liquifaciens, 1.0% Acinetobacter sp., 3.0% Citrobacter sp., 4.0% Enterococci, 0.5% Staphylococcus aureus. Results of sensitivity tests performed with antibiotics Ampicillin, Cotrimoxa.zole, Nitrofurantoin, Nalidixic acid, Gentamicin, Amikacin, Pipemedic acid, Cefotaxime, Azactain and Carbenicillin did not reveal any distinct pattern

Neonatal Screening For Congenital Hypothyroidism In Pakistan, Murntaz Lakhani, Mohammad Khurshid, Shehla H. Naqvi, Mohammad Akber

Department of Paediatrics and Child Health

Congenital hypothyroidism is a preventable cause of mental retardation. Since clinical signs of congenital hypothyroidism do not generally become obvious before three months of age, screening programmes have been introduced in North America and Europe, which consist of T4 or TSH screening on newborn infants on the third day of life. The screening for congenital hypothyroidism was initiated in Pakistan by the Aga Khan University Hospital (AKUH) in March 1987. By April 1988, 5000 neonates were screened and five cases of congenital hypothyroidism were diagnosed. The study revealed the incidence of hypothyroidism to be one case per 1000 newborns which …

Prevalence Of Respiratory Symptoms And Allergic Sensitivity In Multiply Handicapped Children, Dennis R. Ownby, Mary Logan, Ruth Ann Belfi

Henry Ford Hospital Medical Journal

Among the many challenges of providing care for children with multiple physical and developmental handicaps is the proper management of their respiratory difficulties. This study was designed to evaluate the prevalence of respiratory symptoms in children attending a multidisciplinary clinic for handicapped children. We also used several methods to estimate the prevalence of allergic sensitivity in children with respiratory complaints. Questionnaires concerning respiratory symptoms were completed by the parents of 104 patients. The most frequent complaint reported was snoring in 41% of the children. Of the 39% who had multiple respiratory symptoms, 85% had detectable allergen- specific IgE to cat, …

Attention Deficit Disorder: An Overview, Wiley C. Rasbury

Henry Ford Hospital Medical Journal

No abstract provided.

Child Life: Meeting The Psychosocial Needs Of Children And Families In The Hospital, Christine O. Newman, Carol G. Klingbeil, Roberta B. Abrams

Henry Ford Hospital Medical Journal

No abstract provided.

Ovarian Failure In A Chromosomally Competent Adolescent Female: A Case Report, T. Jann Caison-Sorey

Henry Ford Hospital Medical Journal

Primary ovarian failure in adolescence is uncommon. This report depicts such a case in a 17 1/2-year old girl whose investigation revealed elevations in the follicle-stimulating hormone and luteinizing hormone levels in association with a low estrogen level. The blood leukocyte chromosome analysis with Giemsa banding revealed a 46,XX chromosomal complement. Pelvic ultrasound disclosed a rudimentary uterus and a small left ovary. Hormonal replacement has resulted in advancement of secondary sexual characteristics and monthly withdrawal bleeding.

A Practical Approach To Infantile Apnea, Gregory Preston

Henry Ford Hospital Medical Journal

No abstract provided.

Setting Up An Adolescent Clinic In A Suburban Pediatric Office Group Practice, Patricia K. Stoltz, Kathleen B. Blumer

Henry Ford Hospital Medical Journal

Teenagers in the United States experience significant mortality and morbidity because of high-risk behaviors. Adolescents need routine health supervision aimed at reducing these risks. A Teen Clinic within the Pediatrics Clinic at the Henry Ford Hospital Fairlane Center offers separate facilities, longer appointments, and an emphasis on adolescent issues. This plan is a model for practitioners in various office settings who seek to improve adolescent care.

Isolated Cataplexy: A Familial Study, Kristyna M. Hartse, Frank J. Zorick, Jeanne M. Sicklesteel, Thomas Roth

Henry Ford Hospital Medical Journal

Four members of a family, a mother, her two sons, and the mother's second cousin, presented with a history of isolated cataplexy without excessive daytime sleepiness or other symptoms typical of narcolepsy. They were polygraphically monitored during one night followed by a day of multiple nap tests. No subject manifested objective daytime sleepiness as measured by short latencies to sleep onset during daytime naps, and no subject exhibited periods of sleep onset rapid eye movement sleep in either the night or nap recordings. The incidence of isolated cataplexy in this family was traced by history through six generations. We conclude …

The Development Of Pediatrics In The United States, Jay H. Mayefsky

Henry Ford Hospital Medical Journal

No abstract provided.

Duplication And Deletion 11q23-Q24 Recombinants In Two Offspring Of An Intrachromosomal Insertion ("Shift") Carrier, Miriam G. Forsythe, Hugh Walker, Lester Weiss, Jacquelyn R. Roberson, Maria J. Worsham, V. Ramesh Babu, Daniel L. Van Dyke

Henry Ford Hospital Medical Journal

Few examples of intrachromosomal insertions have been described. These usually result from deletion of a segment of chromosome material, with insertion of the deleted material elsewhere on the same chromosome. Previous insertional translocations have been identified through a proband who has either a deletion or a duplication of the inserted segment. We describe a family which has two probands, one with a duplication and one with a deletion of the inserted segment. The unbalanced chromosomes probably resulted from an uneven number of crossovers between the breakpoints in the chromosome 11 of the father, who carries a balanced intrachromosomal insertion of …

The Circumcision Decision: A Plea For Informed Consent, Theresa Spinelli

Henry Ford Hospital Medical Journal

No abstract provided.

Vital Signs, December 1988, Boonshoft School Of Medicine

Vital Signs

A sixteen page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

Dietary And Hormonal Evaluation Of Men At Risk For Prostate Cancer, Donald J. Pusateri

Loma Linda University Electronic Theses, Dissertations & Projects

Relationships between dietary nutrients and plasma and fecal estrone, estradiol-17β, testosterone, and plasma prolactin levels were studied in young Seventh-day Adventist men: 18 nonvegetarians (NV), 20 lacto-ovovegetarians (LOV), and 15 vegans (V). Blood samples and 3 d dietary records were obtained. Contemporaneously collected diet composites and stool samples were analyzed for fiber. The vegetarians consumed significantly more fiber than the omnivores, while NVs and LOVs consumed more saturated fat than the Vs. Although plasma steroid hormone status did not differ, the Vs had significantly higher fecal estrogen levels than the NVs or LOVs. Plasma prolactin levels were significantly higher in …

Physical Linkage Of The Genes For Platelet Membrane Glycoproteins Iib And Iiia., Paul F. Bray, Greg Barsh, Jean-Philippe Rosa, Xue Ya Luo, Ellen Magenis, Marc A. Shuman

Cardeza Foundation for Hematologic Research

The fibrinogen receptor on human platelets is a prototypic member of the integrin family and is composed of subunit glycoproteins IIb (gpIIb) and IIIa (gpIIIa) in a 1:1 stoichiometric ratio. We have isolated cDNA clones for gpIIb and gpIIIa and localized both genes to chromosome 17. In the current study, several approaches were used to localize and map the genes for gpIIb and gpIIIa. A preliminary evaluation of subchromosomal localization was performed by using a panel of mouse-human somatic cell hybrids that contain different amounts of the long arm of human chromosome 17. Southern hybridization to the DNA of these …

Digest Of The Philadelphia College Of Osteopathic Medicine (Fall 1988), Philadelphia College Of Osteopathic Medicine

Digest

The Fall 1988 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Four More on the Floor
• Osteopathic Accomplishments
• A Nursing Viewpoint on Medical Ethics
• On Campus
• Class Acts
• In Memoriam
• Calendar

Spinal Osteoporosis, Charles H. Chesnut Iii

Henry Ford Hospital Medical Journal

No abstract provided.