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Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Southeastern University Of Health Sciences Catalog 1989-1991, Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Oncolog, Volume 34, Number 04, October-December 1989, Gabriel N. Hortobagyi Md

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• For Cancer Patients, Home May Be Their Hospital
• Neoadiuvant Chemotherapy for Patients with Stage III Breast Cancer
• Newer Methods of Delivery To Enhance GI Cancer Treatment

Oncolog, Volume 34, Number 03, July-September 1989, Stephen L. Huber Ms, Nicky Dozier Pharmd, Naguib A. Samaan Md, Phd

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Understanding Dose Intensity is Essential for Optimizing Chemotherapeutic Regimens
• Dysplastic Nevus Syndrome Identifies Patients at High Risk for Melanoma
• Multiple Endocrine Neoplasia Syndromes

Oncolog, Volume 34, Number 02, April-June 1989, Vicki Huff Phd

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Bone Marrow Transplantation Supports Patients through High-Dose Chemotherapy
• Genetic Linkage Analysis of Familial Wilms' Tumor
• Osteosarcoma: Expandable Prostheses and Allografts Reduce the Need for Amputation

Oncolog, Volume 34, Number 01, January-March 1989, Mark S. Roh Md, Lillian M. Fuller Md

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Treatment Options for Colorectal Liver Metastases
• Improved Treatments for Non-Hodgkin's Lymphoma
• Early Discharge for Mastectomy Patients Does Not Increase Morbidity

The Role Of The Insulin Receptor Tyrosine Kinase In Two Models Of Insulin Resistance, Nancy Barchus Block

MUSC Theses and Dissertations

Activation of the insulin receptor tyrosine kinase in vitro and in vivo was studied in two rat models of insulin resistance: hypercortisolemia and streptozotocin-induced diabetes. In control rats, intravenous insulin administration resulted in dose-dependent in vivo activation of the skeletal muscle insulin receptor kinase. Chronic cortisone treatment did not affect the kinase activity of receptors solubilized from muscle after activation with insulin in vivo or in vitro. In contrast, diabetes depressed skeletal muscle insulin receptor kinase activation in vivo by ~50%. Diabetes impaired the in vitro insulin stimulation of receptor kinase activity from skeletal muscle and liver towards the substrate …

Effect Of Intravenous Gammaglobulin On Circulating And Platelet-Bound Antibody In Immune Thrombocytopenia, G Garbano, Mansoor Saleh, P G. Mori, A F. Lobuglio, D Shaw

Haematology and Oncology, East Africa

Ten patients with idiopathic thrombocytopenic purpura (ITP) were studied before and following a rise in circulating platelets subsequent to infusions of intravenous gammaglobulin (400 mg/kg/day x 5 days). We quantitated the amount of circulating IgG capable of binding to normal donor platelets in vitro using an 125I-monoclonal anti-human IgG assay, as well as the amount of IgG associated with the patients' platelets before and following therapy. We found no evidence for a decrease in platelet-specific IgG antibodies in these patients undergoing an acute response to therapy. These data suggest that the short-term efficacy of intravenous gammaglobulin is due to effects …

Vital Signs, December 1988, Boonshoft School Of Medicine

Vital Signs

A sixteen page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

Dietary And Hormonal Evaluation Of Men At Risk For Prostate Cancer, Donald J. Pusateri

Loma Linda University Electronic Theses, Dissertations & Projects

Relationships between dietary nutrients and plasma and fecal estrone, estradiol-17β, testosterone, and plasma prolactin levels were studied in young Seventh-day Adventist men: 18 nonvegetarians (NV), 20 lacto-ovovegetarians (LOV), and 15 vegans (V). Blood samples and 3 d dietary records were obtained. Contemporaneously collected diet composites and stool samples were analyzed for fiber. The vegetarians consumed significantly more fiber than the omnivores, while NVs and LOVs consumed more saturated fat than the Vs. Although plasma steroid hormone status did not differ, the Vs had significantly higher fecal estrogen levels than the NVs or LOVs. Plasma prolactin levels were significantly higher in …

Update - October 1988, Loma Linda University Center For Christian Bioethics

Update

In this issue:

-- International Abortion Conference Convenes November 14-16
-- Clinical ethics intensives begin in January
-- LLU establishes Stahl fund
-- More on Ethics and Aging (Letter)

[ Tobacco Taxes: Are They Moral? ]
-- The Tobacco Tax and Health Protection Act of 1988
-- Why I Oppose the Tobacco Tax Initiative
-- Why I Favor the Tobacco Tax Initiative

-- Anencephalic Infants as Organ Donors (Report)

Developmental Expression Of Pdgf, Tgf-A, And Tgf-J Genes In Preimplantation Mouse Embryos, Daniel A. Rappolee, Carol A. Brenner, Richard Schultz, David Mark, Zena Werb

Department of Obstetrics and Gynecology Research Publications

Control of growth and differentiation during mammalian embryogenesis may be regulated by growth factors from embryonic or maternal sources. With the use of single-cell messenger RNA phenotyping, the simultaneous expression of growth factor transcripts in single or small numbers of preimplantation mouse embryos was examined. Transcripts for platelet-derived growth factor A chain (PDGF-A), trans- forming growth factor (TGF)-a, and TGF- 1, but not for four other growth factors, were found in whole blastocysts. TGF-cx, TGF-(31, and PDGF antigens were detected in blastocysts by immunocytochemistry. Both PDGF-A and TGF-a were detected as maternal transcripts in the unferilized ovulated oocyte, and again …

Metabolic Bone Disease In Children, Michael P. Whyte

Henry Ford Hospital Medical Journal

No abstract provided.

Parathyroid Hormone-Related Disorders, John P. Bilezikian, T. J. Martin

Henry Ford Hospital Medical Journal

No abstract provided.

Vitamin D Metabolism In Health And Disease, Norman H. Bell

Henry Ford Hospital Medical Journal

No abstract provided.

Bone Remodeling, A. M. Parfitt

Henry Ford Hospital Medical Journal

No abstract provided.

Allied Disciplines, Stephen M. Krane

Henry Ford Hospital Medical Journal

No abstract provided.

Metabolic Bone Disease And The Hip, Robert Lindsay

Henry Ford Hospital Medical Journal

No abstract provided.

Miscellaneous Disorders Of Calcium And Bone Metabolism, Gregory R. Mundy

Henry Ford Hospital Medical Journal

No abstract provided.

The Inhibition Of Bone Formation Occurring Under Weightlessness : The Effect Of Skeletal Unloading On Serum Levels Of A Bone-Derived Growth Factor, Jean D. Sibonga

Loma Linda University Electronic Theses, Dissertations & Projects

A deleterious effect of spaceflight on human health is the loss of bone associated with the prolonged lack of gravitational stress on the skeleton. A potential for bone loss is indicated by the hypercalciuria and decreased heel bone density determined in Skylab astronauts. Histological studies of juvenile laboratory rats in actual spaceflight and in simulation models document a suppression of bone formation with little alteration of bone resorption. The mechanism for net bone loss needs to be defined in order to develop measures for its prevention or correction.

Skeletal growth factors, which may mediate coupling and locally regulate bone volume …

Age-Related Changes In Meissner Corpuscles Of Diabetic Mice As Observed By Electron Microscopy, Vicky R. Ras

Loma Linda University Electronic Theses, Dissertations & Projects

Light touch and low-frequency vibration sense are often impaired in diabetic patients. Meissner corpuscles are distally located mechanoreceptors that respond to these stimuli. Peripheral sensory neuropathy in diabetes progresses from distal to proximal, therefore, Meissner corpuscles are ideally suited to study diabetic neuropathy in the C57BL/Ks (db/db) mouse.

Corpuscles from the forepaw digital pads of 9 diabetic and 9 nondiabetic littermates were studied by electron microscopy. These were divided into 3 age groups; 2.5 months, 10 months, and 17 months old.

Ultrastructural changes observed within various receptor components were myelin figures, multivesicular bodies, vacuoles, basal lamina duplication, abnormal and enlarged …

Comparison Of Five Different Serological Assays For Determination Of Antibody Levels Against Herpes Virus Type 1 And 2, Murat Sami Küçük

Loma Linda University Electronic Theses, Dissertations & Projects

To aid in the diagnosis of certain clinical types of Herpes virus infections, we evaluated and compared five serological methods for measuring Herpes virus antibody. The five tests we compared are complement fixation test (CF), indirect immunofluorescent antibody assay (IFA), anticomplementary immunofluorescent assay (ACIF), enzyme linked immunoassay test (ELISA), and the latex agglutination test (LA). The main objective of this study was to establish which of the currently available serologic tests was best suited for clinical laboratory use and which may then replace the complement fixation test. In the comparative testing, one hundred twenty serum samples were divided into four …

Osteoporosis As A Community Health Problem: Lessons Learned From Studying Hypertension, Michael Kleerekoper, Dorothy A. Nelson

Henry Ford Hospital Medical Journal

Campaigns to increase the medical and lay communities' awareness and understanding of the problems of unrecognized and untreated hypertension have led to a progressive decline in morbidity and mortality from hypertension-related diseases. While osteoporosis is also a community health problem, educational and awareness campaigns are still in their infancy and decades may pass before these result in a declining morbidity and mortality from osteoporosis. We identify areas where concepts learned from years of hypertension research might be applicable lo the study of osteoporosis as a community health problem and thereby lessen the time needed to effect a declining morbidity and …

Significance Of Antinuclear Antibody (Ana) Immunofluorescent Patterns And Titers In Systemic Lupus Erythematosus Nephritis, Syed Akbar, Abel I. Tello, Usana Luvira, Rollin Heinzerling, Raymond Romanski, Nathan W. Levin, Thomas K. H. Burnham

Henry Ford Hospital Medical Journal

Seventy-three patients with systemic lupus erythematosus (SLE) nephritis were studied for up to eight years using sequential serologic and renal function tests and renal biopsies. Antinuclear antibody (ANA) patterns and titers were classified into two systems: nonparticulate and particulate. We found a close relationship between disease activity and changes in titers of the nonparticulate peripheral homogeneous system. These changes predicted imminent flare-up or immunosuppressive induced remission of nephritis. Patients with the thready ANA pattern (part of the particulate system) as the main pattern showed a predominant association with membranous glomerulopathy and better renal function than those without threads. The association …

Obesity And Hypertension: A Review, Khaled Imam, James R. Sowers

Henry Ford Hospital Medical Journal

Hypertension is an important risk factor for cardiovascular morbidity and mortality. Obesity is often associated with hypertension. This strong association can be attributed to several pathophysiological changes which occur in obese subjects: increased salt and caloric intake, increased blood volume, increased cardiac output, increased basal as well as stress-stimulated sympathetic nervous system activity, hyperinsulinemia, and a relative increase in renin and aldosterone. Obesity usually increases the preload and causes an eccentric cardiac hypertrophy, while hypertension increases the afterload and causes concentric cardiac hypertrophy. When both obesity and hypertension occur in the same patient (as is often the case), they present …

Morbidity And Treatment Of Clinically Important Obesity: An Internal Medicine Perspective, J. David Fachnie

Henry Ford Hospital Medical Journal

Obesity is defined as an excess storage of energy in the form of fat. The internist generates a differential diagnosis of etiologic factors and examines the patient carefully. Obese persons are counseled on all medical risks of obesity. Choices for treatment vary according lo the severity of the obesity, and alternative dietary treatments include a balanced-deficit diet or a very low calorie diet. Weight loss can be predicted by applying specified equations. With severe obesity, multidisciplinary treatment is needed. Anorexic agents have limited value because of their side effects and because of weight increase after discontinuing therapy. Obesity is not …

Obese Father William Meets A Physician, J. David Fachnie

Henry Ford Hospital Medical Journal

No abstract provided.

Conrad Ramsey Lam, Md: Henry Ford Hospital's First Heart Surgeon, Donald J. Magilligan

Henry Ford Hospital Medical Journal

No abstract provided.

Update - June 1988, Loma Linda University Center For Christian Bioethics

Update

In this issue:

-- LLU schedules clinical ethics seminar for 1989
-- Humphry and Takken debate California death initiative
-- Jack Provonsha lectureship inaugurated at A.P.C.

[ Settings Medical Limits ]
-- Ethics and Old Age
-- A Response to Fletcher
-- How Old is Too Old?

-- Metaphors and Medicine (Review)

The Development And Application Of A Multiple Regression Equation That Predicts The Sum Of Triceps And Subscapular Skinfolds In Children Ages 10-18, Pamela Luna-Raffy

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to develop a tool to predict the sum of triceps and subscapular skinfolds in children ages 10-18. In addition, school-based weight management programs were reviewed.

Skinfold calipers are often used to assess body fat percentage, particularly in non-clinical settings, test sites recommended by researchers are the triceps and The subscapular skinfolds. Recently, however, educators have reported two concerns about using skinfold calipers in the schools: (1) Specialized training and equipment are required, and (2) individuals must remove their clothing from selected test sites.

For schools where the use of calipers present problems, it seemed …