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Extrapleural Hydatid Disease Of Chest: A Case Of Recurrent Hydatid Disease, Ameer Ali Khowaja, Saqib Ali Gowani, Asmatullah Khan, Saulat H. Fatimi

Section of Cardiology

Hydatid disease is a parasitic infestation by a tapeworm of the genus Echinococcus. We present the case of 34-year-old female who complained of chest pain and had a past history of hydatid cyst resection four times in last 15 years. She was found to have extrapleural hyatid cysts of chest that were removed via thoracotomy. The patient fully recovered and experienced an uneventful follow-up.

Identification And Phenotypic Characterization Of A Second Collagen Adhesin, Scm, And Genome-Based Identification And Analysis Of 13 Other Predicted Mscramms, Including Four Distinct Pilus Loci, In Enterococcus Faecium, Jouko Sillanpää, Sreedhar R Nallapareddy, Vittal P Prakash, Xiang Qin, Magnus Höök, George M Weinstock, Barbara E Murray

Faculty, Staff and Student Publications

Attention has recently been drawn to Enterococcus faecium because of an increasing number of nosocomial infections caused by this species and its resistance to multiple antibacterial agents. However, relatively little is known about the pathogenic determinants of this organism. We have previously identified a cell-wall-anchored collagen adhesin, Acm, produced by some isolates of E. faecium, and a secreted antigen, SagA, exhibiting broad-spectrum binding to extracellular matrix proteins. Here, we analysed the draft genome of strain TX0016 for potential microbial surface components recognizing adhesive matrix molecules (MSCRAMMs). Genome-based bioinformatics identified 22 predicted cell-wall-anchored E. faecium surface proteins (Fms), of which 15 …

Elizabeth L. Travis, Phd, Elizabeth L. Travis Phd

Legends and Legacies Book Chapters Archives

No abstract provided.

Cheryl L. Walker, Phd, Cheryl L. Walker Phd

Legends and Legacies Book Chapters Archives

No abstract provided.

Louise Connally Strong, Md, Louise C. Strong

Legends and Legacies Book Chapters Archives

No abstract provided.

S. Eva Singletary, Md, Eva Singletary Md

Legends and Legacies Book Chapters Archives

No abstract provided.

Dihua Yu, Md, Phd, Dihua Yu

Legends and Legacies Book Chapters Archives

No abstract provided.

Sharon Y.R. Dent, Phd, Sharon Y.R. Dent Phd

Legends and Legacies Book Chapters Archives

No abstract provided.

Varsha V. Gandhi, Phd, Varsha V. Gandhi

Legends and Legacies Book Chapters Archives

No abstract provided.

Elizabeth A. Grimm, Phd, Elizabeth A. Grimm Phd

Legends and Legacies Book Chapters Archives

No abstract provided.

Ellen R. Gritz, Phd, Ellen R. Gritz Phd

Legends and Legacies Book Chapters Archives

No abstract provided.

Eugenie S. Kleinerman, Md, Eugenie S. Kleinerman Md

Legends and Legacies Book Chapters Archives

No abstract provided.

Funda Meric-Bernstam, Md, Funda Meric-Bernstam Md

Legends and Legacies Book Chapters Archives

No abstract provided.

M. Alma Rodriguez, Md, Alma Rodriguez Md

Legends and Legacies Book Chapters Archives

No abstract provided.

Vickie R. Shannon, Md, Vickie R. Shannon Md

Legends and Legacies Book Chapters Archives

No abstract provided.

Elizabeth Shpall, Md, Elizabeth Shpall Md

Legends and Legacies Book Chapters Archives

No abstract provided.

Kristen J. Price, Md, Kristen J. Price Md

Legends and Legacies Book Chapters Archives

No abstract provided.

Margaret R. Spitz, Md, Margaret R. Spitz Md

Legends and Legacies Book Chapters Archives

No abstract provided.

Margaret L. Kripke, Phd, Margaret L. Kripke Phd

Legends and Legacies Book Chapters Archives

No abstract provided.

Guillermina Lozano, Phd, Guillermina (Gigi) Lozano Phd

Legends and Legacies Book Chapters Archives

No abstract provided.

Karen H. Lu, Md, Karen H. Lu Md

Legends and Legacies Book Chapters Archives

No abstract provided.

Legends And Legacies: Personal Journeys Of Women Physicians At M.D. Anderson Cancer Center, Elizabeth L. Travis Phd

Legends and Legacies: Personal journeys of women physicians and scientists at M.D. Anderson Cancer Center Archives

No abstract provided.

Sensitivity Of The Human Circadian System To Short Wavelength (420 Nm) Light, George C. Brainard, David Silney, John P. Hanifin, Gena Glickman, Brenda Byrne, Jeffrey M. Greeson, Samar Jasser, Edward Gerner, Mark D. Rollag

Department of Neurology Faculty Papers

The circadian and neurobehavioral effects of light are primarily mediated by a retinal ganglion cell photoreceptor in the mammalian eye containing the photopigment, melanopsin. Nine action spectrum studies using rodents, monkeys, and human for these responses indicate peak sensitivities in the blue region of the visible spectrum ranging from 459 nm to 484 nm, with some disagreement in short wavelength sensitivity of the spectrum. The aim of this work was to quantify the sensitivity of human volunteers to monochromatic 420 nm light for plasma melatonin suppression. Adult female (N=14) and male (N=12) subjects participated in two studies, each employing a …

Molecular Processes That Handle — And Mishandle — Dietary Lipids, Kevin Jon Williams

Department of Medicine Faculty Papers

Overconsumption of lipid-rich diets, in conjunction with physical inactivity, disables and kills staggering numbers of people worldwide. Recent advances in our molecular understanding of cholesterol and triglyceride transport from the small intestine to the rest of the body provide a detailed picture of the fed/fasted and active/sedentary states. Key surprises include the unexpected nature of many pivotal molecular mediators, as well as their dysregulation — but possible reversibility — in obesity, diabetes, inactivity, and related conditions. These mechanistic insights provide new opportunities to correct dyslipoproteinemia, accelerated atherosclerosis, insulin resistance, and other deadly sequelae of overnutrition and underexertion.

Biomarker Identification For Prostate Cancer Using An Efficient Feature Selection Algorithm, Vamsi Krishnam Raju Mantena

Electrical & Computer Engineering Theses & Dissertations

In recent years, there has been an increased interest in using protein mass spectrometry to identify biomarkers that discriminate diseased from healthy individuals. A biomarker is a characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathological processes, or pharmacological responses to a therapeutic intervention. Identifying biomarkers will be an important step towards disease characterization and patient management. One challenge of biomarker identification is how to handle the high dimensional mass spectral data. In this thesis, we applied an efficient feature selection algorithm to mass spectrometry data obtained from prostate tissue samples to identify prostate …

Characterization Of The Inflammatory Cells In Ascending Thoracic Aortic Aneurysms In Patients With Marfan Syndrome, Familial Thoracic Aortic Aneurysms, And Sporadic Aneurysms, Rumin He, Dong-Chuan Guo, Wei Sun, Christina L Papke, Senthil Duraisamy, Anthony L Estrera, Hazim J Safi, Chul Ahn, L Maximilian Buja, Frank C Arnett, Jingwu Zhang, Yong-Jian Geng, Dianna M Milewicz

Faculty, Staff and Student Publications

OBJECTIVE: This study sought to characterize the inflammatory infiltrate in ascending thoracic aortic aneurysm in patients with Marfan syndrome, familial thoracic aortic aneurysm, or nonfamilial thoracic aortic aneurysm.

BACKGROUND: Thoracic aortic aneurysms are associated with a pathologic lesion termed "medial degeneration," which is described as a noninflammatory lesion. Thoracic aortic aneurysms are a complication of Marfan syndrome and can be inherited in an autosomal dominant manner of familial thoracic aortic aneurysm.

METHODS: Full aortic segments were collected from patients undergoing elective repair with Marfan syndrome (n = 5), familial thoracic aortic aneurysm (n = 6), and thoracic aortic aneurysms (n …

Predicting Length Of Treatment For Neonatal Abstinence Syndrome In Methadone-Exposed Neonates., Neil S. Seligman, Nicole Salva, Edward J. Hayes, Kevin C. Dysart, Edward C. Pequignot, Jason K. Baxter

Department of Obstetrics and Gynecology Faculty Papers

OBJECTIVE: The objective of the study was to identify maternal variables predicting length of treatment for neonatal abstinence syndrome (NAS).

STUDY DESIGN: This was a retrospective cohort study of infants treated for NAS during 2000-2006 whose mothers were on methadone maintenance at delivery. Mixed-effects linear regression was used to examine the interaction of maternal and neonatal variables with length of treatment.

RESULTS: Of 204 neonates born to methadone exposed mothers, the average dose at delivery was 127 mg daily (25-340 mg) with median length of treatment 32 days (1-122 days). Trimester of initial exposure (P = .33), methadone dose at …

Substance Use Among Persons With Syphilis During Pregnancy — Arizona And Georgia, 2018–2021, Lingpeng Cheng, Qin Fang, Sanket Shah, Ivo C Atanasov, Z Hong Zhou

Faculty, Staff and Student Publications

Grass carp reovirus (GCRV) is a member of the Aquareovirus genus of the family Reoviridae, a large family of double-stranded RNA (dsRNA) viruses infecting plants, insects, fishes and mammals. We report the first subnanometer-resolution three-dimensional structures of both GCRV core and virion by cryoelectron microscopy. These structures have allowed the delineation of interactions among the over 1000 molecules in this enormous macromolecular machine and a detailed comparison with other dsRNA viruses at the secondary-structure level. The GCRV core structure shows that the inner proteins have strong structural similarities with those of orthoreoviruses even at the level of secondary-structure elements, indicating …

Off-Label Psychopharmacologic Prescribing For Children: History Supports Close Clinical Monitoring., Julie M. Zito, Albert T. Derivan, Christopher J. Kratochvil, Daniel J. Safer, Joerg M. Fegert, Laurence L. Greenhill

Journal Articles: Psychiatry

The review presents pediatric adverse drug events from a historical perspective and focuses on selected safety issues associated with off-label use of medications for the psychiatric treatment of youth. Clinical monitoring procedures for major psychotropic drug classes are reviewed. Prior studies suggest that systematic treatment monitoring is warranted so as to both minimize risk of unexpected adverse events and exposures to ineffective treatments. Clinical trials to establish the efficacy and safety of drugs currently being used off-label in the pediatric population are needed. In the meantime, clinicians should consider the existing evidence-base for these drugs and institute close clinical monitoring.

Genetic Analysis Of Hiv-1 Subtypes In Nairobi, Kenya, Suhail Khoja, Peter Ojwang, Saeed Khan, Nancy Okinda, Reena Harania, Syed Ali

Pathology, East Africa

Background: Genetic analysis of a viral infection helps in following its spread in a given population, in tracking the routes of infection and, where applicable, in vaccine design. Additionally, sequence analysis of the viral genome provides information about patterns of genetic divergence that may have occurred during viral evolution.

Objective: In this study we have analyzed the subtypes of Human Immunodeficiency Virus -1 (HIV-1) circulating in a diverse sample population of Nairobi, Kenya.

Methodology: 69 blood samples were collected from a diverse subject population attending the Aga Khan University Hospital in Nairobi, Kenya. Total DNA was extracted from peripheral blood …