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Assessment Of A Mouse Xenograft Model Of Primary Colorectal Cancer With Special Reference To Perfluorooctane Sulfonate, Jeffrey H. Wimsatt, Caitlin Montgomery, Laurel S. Thomas, Charity Savard, Rachel Tallman, Kim Innes, Nezar Jrebi Jan 2018

Assessment Of A Mouse Xenograft Model Of Primary Colorectal Cancer With Special Reference To Perfluorooctane Sulfonate, Jeffrey H. Wimsatt, Caitlin Montgomery, Laurel S. Thomas, Charity Savard, Rachel Tallman, Kim Innes, Nezar Jrebi

Faculty & Staff Scholarship

Colorectal cancer ranks third among the most commonly diagnosed cancers in the United States. Current therapies have a range of side effects, and the development of a reliable animal model to speed the discovery of safe effective preventative therapies would be of great value. A cross-sectional study in a large Appalachian population recently showed an association between low circulating levels of perfluorooctane sulfonate (PFOS) and a reduced prevalence of colorectal cancer. A study using APCmin(C57BL/6J-ApcMin/J) mice prone to familial adenomatous polyposis found PFOS was protective when exposure occurred during tumor development. To test the possible benefit of PFOS on spontaneous …

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Metabolic And Transcriptional Modules Independently Diversify Plasma Cell Lifespan And Function, Wing Y. Lam, Arijita Jash, Cong-Hui Yao, Lucas D'Souza, Rachel Wong, Ryan M. Nunley, Gordon P. Meares, Gary J. Patti, Deepta Bhattacharya Jan 2018

Metabolic And Transcriptional Modules Independently Diversify Plasma Cell Lifespan And Function, Wing Y. Lam, Arijita Jash, Cong-Hui Yao, Lucas D'Souza, Rachel Wong, Ryan M. Nunley, Gordon P. Meares, Gary J. Patti, Deepta Bhattacharya

Faculty & Staff Scholarship

Plasma cell survival and the consequent duration of immunity vary widely with infection or vaccination. Using fluorescent glucose analog uptake, we defined multiple developmentally independent mouse plasma cell populations with varying life- spans. Long-lived plasma cells imported more fluo- rescent glucose analog, expressed higher surface levels of the amino acid transporter CD98, and had more autophagosome mass than did short-lived cells. Low amino acid concentrations triggered re- ductions in both antibody secretion and mitochon- drial respiration, especially by short-lived plasma cells. To explain these observations, we found that glutamine was used for both mitochondrial respira- tion and anaplerotic reactions, yielding …

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Noninfectious Manifestations And Complications Of Chronic Granulomatous Disease, S. E. Henrickson, A. M. Jongco, K. F. Thomsen, E. K. Garabedian, I. P. Thomsen Jan 2018

Noninfectious Manifestations And Complications Of Chronic Granulomatous Disease, S. E. Henrickson, A. M. Jongco, K. F. Thomsen, E. K. Garabedian, I. P. Thomsen

Journal Articles

© The Author(s) 2018. Chronic granulomatous disease (CGD), a primary immunodeficiency characterized by a deficient neutrophil oxidative burst and the inadequate killing of microbes, is well known to cause a significantly increased risk of invasive infection. However, infectious complications are not the sole manifestations of CGD; substantial additional morbidity is driven by noninfectious complications also. These complications can include, for example, a wide range of inflammatory diseases that affect the gastrointestinal tract, lung, skin, and genitourinary tract and overt autoimmune disease. These diseases can occur at any age and are especially problematic in adolescents and adults with CGD. Many of …

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Integration Of Routine Qa Data Into Mega-Analysis May Improve Quality And Sensitivity Of Multisite Diffusion Tensor Imaging Studies, P. Kochunov, E. W. Dickie, J. D. Viviano, J. Turner, P. B. Kingsley, N. Jahanshad, P. M. Thompson, M. C. Ryan, A. K. Malhotra, A. N. Voineskos, +6 Additional Authors Jan 2018

Integration Of Routine Qa Data Into Mega-Analysis May Improve Quality And Sensitivity Of Multisite Diffusion Tensor Imaging Studies, P. Kochunov, E. W. Dickie, J. D. Viviano, J. Turner, P. B. Kingsley, N. Jahanshad, P. M. Thompson, M. C. Ryan, A. K. Malhotra, A. N. Voineskos, +6 Additional Authors

Journal Articles

No abstract provided.

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Greater Extracellular Free-Water In First-Episode Psychosis Predicts Better Neurocognitive Functioning, A. E. Lyall, O. Pasternak, D. G. Robinson, D. Newell, J. W. Trampush, J. A. Gallego, M. Fava, A. K. Malhotra, K. H. Karlsgodt, P. R. Szeszko, +1 Additional Author Jan 2018

Greater Extracellular Free-Water In First-Episode Psychosis Predicts Better Neurocognitive Functioning, A. E. Lyall, O. Pasternak, D. G. Robinson, D. Newell, J. W. Trampush, J. A. Gallego, M. Fava, A. K. Malhotra, K. H. Karlsgodt, P. R. Szeszko, +1 Additional Author

Journal Articles

No abstract provided.

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A Daily Diary Study Of Stressful And Positive Events, Alcohol Use, And Addiction Severity Among Heavy Drinking Sexual Minority Men, E. H. Mereish, A. Kuerbis, J. Morgenstern Jan 2018

A Daily Diary Study Of Stressful And Positive Events, Alcohol Use, And Addiction Severity Among Heavy Drinking Sexual Minority Men, E. H. Mereish, A. Kuerbis, J. Morgenstern

Journal Articles

© 2018 Elsevier B.V. Background: The purpose of this study is to examine the conditions under which daily stressful and positive events are associated with alcohol use among heavy drinking sexual minority men (SMM). Specifically, we examined the moderating effects of two indicators of alcohol addiction severity (i.e., alcohol dependence severity and negative drinking consequences) on the associations between daily stressful events and alcohol use and between daily positive events and alcohol use among heavy drinking SMM. Procedures: Secondary data analyses were performed using data from a randomized controlled trial of heavy drinking and treatment seeking SMM who were assigned …

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Correlation Of High-Risk Soft Tissue Sarcoma Biomarker Expression Patterns With Outcome Following Neoadjuvant Chemoradiation, J. M. Kane, A. Magliocco, Q. Zhang, D. Wang, A. Klimowicz, J. Harris, J. Simko, T. Delaney, W. Kraybill, D. G. Kirsch Jan 2018

Correlation Of High-Risk Soft Tissue Sarcoma Biomarker Expression Patterns With Outcome Following Neoadjuvant Chemoradiation, J. M. Kane, A. Magliocco, Q. Zhang, D. Wang, A. Klimowicz, J. Harris, J. Simko, T. Delaney, W. Kraybill, D. G. Kirsch

Journal Articles

© 2018 John M. Kane III et al. Background. Sarcoma mortality remains high despite adjuvant chemotherapy. Biomarker predictors of treatment response and outcome could improve treatment selection. Methods. Tissue microarrays (TMAs) were created using pre- and posttreatment tumor from two prospective trials (MGH pilot and RTOG 9514) of neoadjuvant/adjuvant MAID chemotherapy and preoperative radiation. Biomarkers were measured using automated computerized imaging (AQUA or ACIS). Expression was correlated with disease-free survival (DFS), distant disease-free survival (DDFS), and overall survival (OS). Results. Specimens from 60 patients included 23 pretreatment (PRE), 40 posttreatment (POST), and 12 matched pairs (MPs). In the MP set, …

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Prevalence And Predictors Of Hair Pulling Disorder And Excoriation Disorder In Tourette Syndrome, E. Greenberg, E. S. Tung, C. Gauvin, L. Osiecki, K. G. Yang, E. Curley, A. Essa, C. Illmann, C. L. Budman, J. M. Scharf, +10 Additional Authors Jan 2018

Prevalence And Predictors Of Hair Pulling Disorder And Excoriation Disorder In Tourette Syndrome, E. Greenberg, E. S. Tung, C. Gauvin, L. Osiecki, K. G. Yang, E. Curley, A. Essa, C. Illmann, C. L. Budman, J. M. Scharf, +10 Additional Authors

Journal Articles

No abstract provided.

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Malignant Adnexal Tumors Of The Skin: A Single Institution Experience, T. Oyasiji, W. Tan, J. Kane, J. Skitzki, V. Francescutti, K. Salerno, N. I. Khushalani Jan 2018

Malignant Adnexal Tumors Of The Skin: A Single Institution Experience, T. Oyasiji, W. Tan, J. Kane, J. Skitzki, V. Francescutti, K. Salerno, N. I. Khushalani

Journal Articles

© 2018 The Author(s). Background: Malignant adnexal tumors of the skin (MATS) are rare. We aimed to measure the survival of patients with MATS and identify predictors of improved survival. Methods: A retrospective review of MATS treated at our institution from 1990 to 2012. Results: There were 50 patients within the time period. Median age was 59.5 years (range 22-95); primary site was the head and neck (52%); most common histologic subtypes were skin appendage carcinoma (20%) and eccrine adenocarcinoma (20%); and the vast majority were T1 (44%). Most patients (98%) underwent surgical treatment. Chemotherapy and radiation were administered to …

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Initiating/Maintaining Long-Acting Injectable Antipsychotics In Schizophrenia/Schizoaffective Or Bipolar Disorder - Expert Consensus Survey Part 2, M. Sajatovic, R. Ross, S. N. Legacy, M. Byerly, J. M. Kane, F. Dibiasi, H. Fitzgerald, C. U. Correll Jan 2018

Initiating/Maintaining Long-Acting Injectable Antipsychotics In Schizophrenia/Schizoaffective Or Bipolar Disorder - Expert Consensus Survey Part 2, M. Sajatovic, R. Ross, S. N. Legacy, M. Byerly, J. M. Kane, F. Dibiasi, H. Fitzgerald, C. U. Correll

Journal Articles

No abstract provided.

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Genome-Wide Association Study Of Cognitive Flexibility Assessed By The Wisconsin Card Sorting Test, H. Zhang, H. Zhou, T. Lencz, L. A. Farrer, H. R. Kranzler, J. Gelernter Jan 2018

Genome-Wide Association Study Of Cognitive Flexibility Assessed By The Wisconsin Card Sorting Test, H. Zhang, H. Zhou, T. Lencz, L. A. Farrer, H. R. Kranzler, J. Gelernter

Journal Articles

No abstract provided.

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Gene Discovery And Polygenic Prediction From A Genome-Wide Association Study Of Educational Attainment In 1.1 Million Individuals, J. J. Lee, R. Wedow, A. Okbay, E. Kong, O. Maghzian, M. Zacher, A. N. Tuan, T. Lencz, A. K. Malhotra, D. Cesarini, +67 Additional Authors Jan 2018

Gene Discovery And Polygenic Prediction From A Genome-Wide Association Study Of Educational Attainment In 1.1 Million Individuals, J. J. Lee, R. Wedow, A. Okbay, E. Kong, O. Maghzian, M. Zacher, A. N. Tuan, T. Lencz, A. K. Malhotra, D. Cesarini, +67 Additional Authors

Journal Articles

No abstract provided.

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What's In A Name? Moving To Neuroscience-Based Nomenclature In Pediatric Psychopharmacology, R. S. Sultan, C. U. Correll, J. Zohar, G. Zalsman, J. Veenstra-Vanderweele Jan 2018

What's In A Name? Moving To Neuroscience-Based Nomenclature In Pediatric Psychopharmacology, R. S. Sultan, C. U. Correll, J. Zohar, G. Zalsman, J. Veenstra-Vanderweele

Journal Articles

© 2018 American Academy of Child and Adolescent Psychiatry Our traditional names for psychotropic medication classes lead to unnecessary confusion. As clinicians, we have grown comfortable with idiosyncratic names of psychotropic medications and have forgotten how unclear and misleading they can be. For example, evidence shows that serotonin reuptake inhibitors help in pediatric anxiety disorders, but a parent with an anxious child might ask, “If you diagnosed my son with separation anxiety, why are you giving him an antidepressant?” Another parent might object to the use of a “stimulant” medication, “My daughter never slows down, the last thing she needs …

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Grk5 Is Associated With The Regulation Of Methadone Dosage In Heroin Dependence, S. C. Wang, R. H. Chung, H. W. Kuo, T. H. Liu, C. P. Fang, S. C. Liu, C. C. Liu, H. H. Tsou, A. C. Chen, Y. L. Liu Jan 2018

Grk5 Is Associated With The Regulation Of Methadone Dosage In Heroin Dependence, S. C. Wang, R. H. Chung, H. W. Kuo, T. H. Liu, C. P. Fang, S. C. Liu, C. C. Liu, H. H. Tsou, A. C. Chen, Y. L. Liu

Journal Articles

© The Author(s) 2018. Background There is no countable biomarker for opioid dependence treatment responses thus far. In this study, we recruited Taiwanese methadone maintenance treatment patients to search for genes involving the regulatory mechanisms of methadone dose by genome-wide association analyses. Methods A total of 344 Taiwanese methadone maintenance treatment patients were included in a genome-wide association study. The involvement of GRK5 in opioid dependence was then further confirmed by gene expression study on lymphoblastoid cell lines derived from 3 independent age- and gender-matched groups: Methadone maintenance treatment patients, medication-free former heroin abusers, and normal controls. Results The results …

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Overexpression Of Β1 Integrin Contributes To Polarity Reversal And A Poor Prognosis Of Breast Invasive Micropapillary Carcinoma, B. Liu, X. Zheng, F. Meng, Y. Han, Y. Song, F. Liu, S. Li, L. Zhang, X. Zhang, L. Fu, +1 Additional Author Jan 2018

Overexpression Of Β1 Integrin Contributes To Polarity Reversal And A Poor Prognosis Of Breast Invasive Micropapillary Carcinoma, B. Liu, X. Zheng, F. Meng, Y. Han, Y. Song, F. Liu, S. Li, L. Zhang, X. Zhang, L. Fu, +1 Additional Author

Journal Articles

© Liu et al. Invasive micropapillary carcinoma (IMPC) of the breast is a highly aggressive breast cancer. Polarity reversal exemplified by cluster growth is hypothesized to contribute to the invasiveness and metastasis of IMPC. In this study, we demonstrate that levels of β1 integrin and Rac1 expression were greater in breast IMPC than in invasive breast carcinoma of no specific type and paraneoplastic benign breast tissue. We show that silencing β1 integrin expression using the β1 integrin inhibitor AIIB2 partially restored polarity in IMPC primary cell clusters and downregulated Rac1. Thus, overexpression of β1 integrin upregulates Rac1. Univariate analysis showed …

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Stromal Infiltration Of Tumor-Associated Macrophages Conferring Poor Prognosis Of Patients With Basal-Like Breast Carcinoma, M. Yang, Z. Li, M. Ren, S. Li, L. Zhang, X. Zhang, F. Liu Jan 2018

Stromal Infiltration Of Tumor-Associated Macrophages Conferring Poor Prognosis Of Patients With Basal-Like Breast Carcinoma, M. Yang, Z. Li, M. Ren, S. Li, L. Zhang, X. Zhang, F. Liu

Journal Articles

© Ivyspring International Publisher. Aims: Tumor associated macrophages (TAMs) play a critical role in the initiation and progression of breast cancer. However, their prognostic significance in the molecular subtype of basal-like breast cancer (BLBC) is poorly understood. The aim of this study was to investigate the extent and patterns of TAMs in BLBC and their associations with clinicopathological features and patient survival. Methods and Results: We evaluated TAMs in 200 cases of BLBC by immunohistochemistry using the M2 macrophage marker CD163 and the pan-macrophage marker CD68 in tumor nest and stroma, and assessed their prognostic significance. The study demonstrated that …

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Phosphoglycerate Mutase 1 Is Highly Expressed In C6 Glioma Cells And Human Astrocytoma, Z. Liu, J. Ding, C. Du, N. Xu, E. Wang, J. Li, Y. Wang, J. Yu Jan 2018

Phosphoglycerate Mutase 1 Is Highly Expressed In C6 Glioma Cells And Human Astrocytoma, Z. Liu, J. Ding, C. Du, N. Xu, E. Wang, J. Li, Y. Wang, J. Yu

Journal Articles

No abstract provided.

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Lung Epithelial Cell-Derived Il-25 Negatively Regulates Lps-Induced Exosome Release From Macrophages, Z. G. Li, M. J. Scott, T. Brzóska, P. Sundd, Y. H. Li, T. R. Billiar, M. A. Wilson, P. Wang, J. Fan Jan 2018

Lung Epithelial Cell-Derived Il-25 Negatively Regulates Lps-Induced Exosome Release From Macrophages, Z. G. Li, M. J. Scott, T. Brzóska, P. Sundd, Y. H. Li, T. R. Billiar, M. A. Wilson, P. Wang, J. Fan

Journal Articles

© 2018 The Author(s). Background: Acute lung injury (ALI) is a major component of multiple organ dysfunction syndrome (MODS) following pulmonary and systemic infection. Alveolar macrophages (AMΦ) are at the center of ALI pathogenesis. Emerging evidence has shown that cell-cell interactions in the lungs play an important regulatory role in the development of acute lung inflammation. However, the underneath mechanisms remain poorly addressed. In this study, we explore a novel function of lung epithelial cells (LEPCs) in regulating the release of exosomes from AMΦ following LPS stimulation. Methods: For the in vivo experiments, C57BL/6 wildtype (WT) mice were treated with …

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Structural Brain Abnormalities In The Common Epilepsies Assessed In A Worldwide Enigma Study, C. D. Whelan, A. Altmann, J. A. Botia, N. Jahanshad, D. P. Hibar, J. Absil, Alhusaini, M. K. M. Alvim, R. Kuzniecky, S. M. Sisodiya, +81 Additional Authors Jan 2018

Structural Brain Abnormalities In The Common Epilepsies Assessed In A Worldwide Enigma Study, C. D. Whelan, A. Altmann, J. A. Botia, N. Jahanshad, D. P. Hibar, J. Absil, Alhusaini, M. K. M. Alvim, R. Kuzniecky, S. M. Sisodiya, +81 Additional Authors

Journal Articles

No abstract provided.

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Safety And Efficacy Of A 3-Dimensional Stent Retriever With Aspiration-Based Thrombectomy Vs Aspiration-Based Thrombectomy Alone In Acute Ischemic Stroke Intervention A Randomized Clinical Trial, R. G. Nogueira, D. Frei, J. F. Kirmani, O. Zaidat, D. Lopes, A. S. Turk, D. Heck, B. Mason, D. Langer, A. Siddiqui, +9 Additional Authors Jan 2018

Safety And Efficacy Of A 3-Dimensional Stent Retriever With Aspiration-Based Thrombectomy Vs Aspiration-Based Thrombectomy Alone In Acute Ischemic Stroke Intervention A Randomized Clinical Trial, R. G. Nogueira, D. Frei, J. F. Kirmani, O. Zaidat, D. Lopes, A. S. Turk, D. Heck, B. Mason, D. Langer, A. Siddiqui, +9 Additional Authors

Journal Articles

No abstract provided.

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Retrospective Chart Review Of Synthetic Cannabinoid Intoxication With Toxicologic Analysis, P. Sud, M. Gordon, L. Tortora, M. Stripp, D. Borg, A. Berman Jan 2018

Retrospective Chart Review Of Synthetic Cannabinoid Intoxication With Toxicologic Analysis, P. Sud, M. Gordon, L. Tortora, M. Stripp, D. Borg, A. Berman

Journal Articles

© 2018 Sud et al. Introduction: Use of synthetic cannabinoids (SC) has recently emerged as a new drug epidemic. Our emergency departments (EDs) received a surge of SC users presenting with lethargy and bradycardia, contrasting prior reports of SC-induced tachycardia and agitation.Our goal was to describe these novel presentations and characterize the compounds. Methods: We present a case series of patients with SC intoxication who presented to our toxicology service covering two tertiary care EDs between 2/11/2015 and 6/23/2015. A retrospective chart review recorded initial vital signs, chief complaint and clinical course. Urine, blood and xenobiotic samples were analyzed using …

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Somatic Mosaicism Of An Intragenic Fancb Duplication In Both Fibroblast And Peripheral Blood Cells Observed In A Fanconi Anemia Patient Leads To Milder Phenotype, R. S. Asur, D. C. Kimble, F. P. Lach, M. Jung, F. X. Donovan, A. Kamat, R. J. Noonan, J. W. Thomas, A. Vlachos, S. C. Chandrasekharappa, +4 Additional Authors Jan 2018

Somatic Mosaicism Of An Intragenic Fancb Duplication In Both Fibroblast And Peripheral Blood Cells Observed In A Fanconi Anemia Patient Leads To Milder Phenotype, R. S. Asur, D. C. Kimble, F. P. Lach, M. Jung, F. X. Donovan, A. Kamat, R. J. Noonan, J. W. Thomas, A. Vlachos, S. C. Chandrasekharappa, +4 Additional Authors

Journal Articles

© 2017 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals, Inc. Background: Fanconi anemia (FA) is a rare disorder characterized by congenital malformations, progressive bone marrow failure, and predisposition to cancer. Patients harboring X-linked FANCB pathogenic variants usually present with severe congenital malformations resembling VACTERL syndrome with hydrocephalus. Methods: We employed the diepoxybutane (DEB) test for FA diagnosis, arrayCGH for detection of duplication, targeted capture and next-gen sequencing for defining the duplication breakpoint, PacBio sequencing of full-length FANCB aberrant transcript, FANCD2 ubiquitination and foci formation assays for the evaluation of FANCB protein function by viral transduction of …

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Enhanced Contribution Of Hla In Pediatric Onset Ulcerative Colitis, S. Venkateswaran, J. Prince, D. J. Cutler, U. M. Marigorta, D. T. Okou, S. Prahalad, D. Mack, B. Boyle, J. Markowitz, S. Kugathasan, +20 Additional Authors Jan 2018

Enhanced Contribution Of Hla In Pediatric Onset Ulcerative Colitis, S. Venkateswaran, J. Prince, D. J. Cutler, U. M. Marigorta, D. T. Okou, S. Prahalad, D. Mack, B. Boyle, J. Markowitz, S. Kugathasan, +20 Additional Authors

Journal Articles

© 2018 Crohn's & Colitis Foundation. Published by Oxford University Press on behalf of Crohn's & Colitis Foundation. Background The genetic contributions to pediatric onset ulcerative colitis (UC), characterized by severe disease and extensive colonic involvement, are largely unknown. In adult onset UC, Genome Wide Association Study (GWAS) has identified numerous loci, most of which have a modest susceptibility risk (OR 0.84-1.14), with the exception of the human leukocyte antigen (HLA) region on Chromosome 6 (OR 3.59). Method To study the genetic contribution to exclusive pediatric onset UC, a GWAS was performed on 466 cases with 2099 healthy controls using …

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Barriers To Adherence In Juvenile Idiopathic Arthritis: A Multicenter Collaborative Experience And Preliminary Results, L. A. Favier, J. Taylor, K. L. Rich, K. B. Jones, S. S. Vora, J. G. Harris, B. S. Gottlieb, L. Robbins, J. T. Lai, A. C. Modi, +7 Additional Authors Jan 2018

Barriers To Adherence In Juvenile Idiopathic Arthritis: A Multicenter Collaborative Experience And Preliminary Results, L. A. Favier, J. Taylor, K. L. Rich, K. B. Jones, S. S. Vora, J. G. Harris, B. S. Gottlieb, L. Robbins, J. T. Lai, A. C. Modi, +7 Additional Authors

Journal Articles

© 2018. All rights reserved. Objective. Nonadherence is currently an underrecognized and potentially modifiable obstacle to care in juvenile idiopathic arthritis (JIA). The purpose of our study was to design and implement a standardized approach to identifying adherence barriers for youth with JIA across 7 pediatric rheumatology clinics through the Pediatric Rheumatology Care and Outcomes Improvement Network (PR-COIN) and to assess the frequency of adherence barriers in patients and their caregivers across treatment modalities. Methods. An iterative process using coproduction among parents and providers of patients with JIA was used to design the Barriers Assessment Tool to screen for adherence …

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Increased Prevalence Of Congenital Heart Disease In Children With Diamond Blackfan Anemia Suggests Unrecognized Diamond Blackfan Anemia As A Cause Of Congenital Heart Disease In The General Population: A Report Of The Diamond Blackfan Anemia Registry., A. Vlachos, D. S. Osorio, E. Atsidaftos, J. Kang, M. L. Lababidi, H. S. Seiden, D. Gruber, B. E. Glader, K. Onel, J. M. Lipton, +6 Additional Authors Jan 2018

Increased Prevalence Of Congenital Heart Disease In Children With Diamond Blackfan Anemia Suggests Unrecognized Diamond Blackfan Anemia As A Cause Of Congenital Heart Disease In The General Population: A Report Of The Diamond Blackfan Anemia Registry., A. Vlachos, D. S. Osorio, E. Atsidaftos, J. Kang, M. L. Lababidi, H. S. Seiden, D. Gruber, B. E. Glader, K. Onel, J. M. Lipton, +6 Additional Authors

Journal Articles

No abstract provided.

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A Functional Assay For The Clinical Annotation Of Genetic Variants Of Uncertain Significance In Diamond–Blackfan Anemia, A. Aspesi, M. Betti, M. Sculco, C. Actis, C. Olgasi, M. W. Wlodarski, A. Vlachos, J. M. Lipton, U. Ramenghi, I. Dianzani, +3 Additional Authors Jan 2018

A Functional Assay For The Clinical Annotation Of Genetic Variants Of Uncertain Significance In Diamond–Blackfan Anemia, A. Aspesi, M. Betti, M. Sculco, C. Actis, C. Olgasi, M. W. Wlodarski, A. Vlachos, J. M. Lipton, U. Ramenghi, I. Dianzani, +3 Additional Authors

Journal Articles

© 2018 The Authors. Human Mutation published by Wiley Periodicals, Inc. Diamond–Blackfan anemia (DBA) is a rare genetic hypoplasia of erythroid progenitors characterized by mild to severe anemia and associated with congenital malformations. Clinical manifestations in DBA patients are quite variable and genetic testing has become a critical factor in establishing a diagnosis of DBA. The majority of DBA cases are due to heterozygous loss-of-function mutations in ribosomal protein (RP) genes. Causative mutations are fairly straightforward to identify in the case of large deletions and frameshift and nonsense mutations found early in a protein coding sequence, but diagnosis becomes more …

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Minimum Quality Threshold In Pre-Clinical Sepsis Studies (Mqtipss): An International Expert Consensus Initiative For Improvement Of Animal Modeling In Sepsis., M. F. Osuchowski, A. Ayala, S. Bahrami, M. Bauer, M. Boros, J. Cavaillon, I. H. Chaudry, C. S. Deutschman, P. Wang, B. Zingarelli, +21 Additional Authors Jan 2018

Minimum Quality Threshold In Pre-Clinical Sepsis Studies (Mqtipss): An International Expert Consensus Initiative For Improvement Of Animal Modeling In Sepsis., M. F. Osuchowski, A. Ayala, S. Bahrami, M. Bauer, M. Boros, J. Cavaillon, I. H. Chaudry, C. S. Deutschman, P. Wang, B. Zingarelli, +21 Additional Authors

Journal Articles

Preclinical animal studies precede the majority of clinical trials. While the clinical definitions of sepsis and recommended treatments are regularly updated, a systematic review of preclinical models of sepsis has not been done and clear modeling guidelines are lacking. To address this deficit, a Wiggers-Bernard Conference on preclinical sepsis modeling was held in Vienna in May, 2017. The goal of the conference was to identify limitations of preclinical sepsis models and to propose a set of guidelines, defined as the "Minimum Quality Threshold in Preclinical Sepsis Studies" (MQTiPSS), to enhance translational value of these models. A total of 31 experts …

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Minimum Quality Threshold In Pre-Clinical Sepsis Studies (Mqtipss): An International Expert Consensus Initiative For Improvement Of Animal Modeling In Sepsis., M. F. Osuchowski, A. Ayala, S. Bahrami, M. Bauer, M. Boros, J. Cavaillon, I. H. Chaudry, C. Deutschman, P. Wang, B. Zingarelli, +21 Additional Authors Jan 2018

Minimum Quality Threshold In Pre-Clinical Sepsis Studies (Mqtipss): An International Expert Consensus Initiative For Improvement Of Animal Modeling In Sepsis., M. F. Osuchowski, A. Ayala, S. Bahrami, M. Bauer, M. Boros, J. Cavaillon, I. H. Chaudry, C. Deutschman, P. Wang, B. Zingarelli, +21 Additional Authors

Journal Articles

BACKGROUND:Pre-clinical animal studies precede the majority of clinical trials. While the clinical definitions of sepsis and recommended treatments are regularly updated, a systematic review of pre-clinical models of sepsis has not been done and clear modeling guidelines are lacking. OBJECTIVE:To address this deficit, a Wiggers-Bernard Conference on pre-clinical sepsis modeling was held in Vienna in May 2017. The goal of the conference was to identify limitations of pre-clinical sepsis models and to propose a set of guidelines, defined as the "Minimum Quality Threshold in Pre-Clinical Sepsis Studies" (MQTiPSS), to enhance translational value of these models. METHODS:A total of 31 experts …

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Hyposialylated Igg Activates Endothelial Igg Receptor Fcγriib To Promote Obesity-Induced Insulin Resistance, K. Tanigaki, A. Sacharidou, J. Peng, K. L. Chambliss, I. S. Yuhanna, D. Ghosh, M. Ahmed, A. J. Szalai, W. Vongpatanasin, C. Mineo, +10 Additional Authors Jan 2018

Hyposialylated Igg Activates Endothelial Igg Receptor Fcγriib To Promote Obesity-Induced Insulin Resistance, K. Tanigaki, A. Sacharidou, J. Peng, K. L. Chambliss, I. S. Yuhanna, D. Ghosh, M. Ahmed, A. J. Szalai, W. Vongpatanasin, C. Mineo, +10 Additional Authors

Journal Articles

Type 2 diabetes mellitus (T2DM) is a common complication of obesity. Here, we have shown that activation of the IgG receptor FcγRIIB in endothelium by hyposialylated IgG plays an important role in obesity-induced insulin resistance. Despite becoming obese on a high-fat diet (HFD), mice lacking FcγRIIB globally or selectively in endothelium were protected from insulin resistance as a result of the preservation of insulin delivery to skeletal muscle and resulting maintenance of muscle glucose disposal. IgG transfer in IgG-deficient mice implicated IgG as the pathogenetic ligand for endothelial FcγRIIB in obesity-induced insulin resistance. Moreover, IgG transferred from patients with T2DM …

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Cpx-351 (Cytarabine And Daunorubicin) Liposome For Injection Versus Conventional Cytarabine Plus Daunorubicin In Older Patients With Newly Diagnosed Secondary Acute Myeloid Leukemia, J. E. Lancet, G. L. Uy, J. E. Cortes, L. F. Newell, T. L. Lin, E. K. Ritchie, R. K. Stuart, S. A. Strickland, J. E. Kolitz, B. C. Medeiros, +11 Additional Authors Jan 2018

Cpx-351 (Cytarabine And Daunorubicin) Liposome For Injection Versus Conventional Cytarabine Plus Daunorubicin In Older Patients With Newly Diagnosed Secondary Acute Myeloid Leukemia, J. E. Lancet, G. L. Uy, J. E. Cortes, L. F. Newell, T. L. Lin, E. K. Ritchie, R. K. Stuart, S. A. Strickland, J. E. Kolitz, B. C. Medeiros, +11 Additional Authors

Journal Articles

© 2018 by American Society of Clinical Oncology. Purpose CPX-351 is a dual-drug liposomal encapsulation of cytarabine and daunorubicin that delivers a synergistic 5:1 drug ratio into leukemia cells to a greater extent than normal bone marrow cells. Prior clinical studies demonstrated a sustained drug ratio and exposure in vivo and prolonged survival versus standard-of-care cytarabine plus daunorubicin chemotherapy (7+3 regimen) in older patients with newly diagnosed secondary acute myeloid leukemia (sAML). Patients and Methods In this open-label, randomized, phase III trial, 309 patients age 60 to 75 years with newly diagnosed high-risk/sAML received one to two induction cycles of …

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