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Muscle Pathology In Total Knee Replacement For Severe Osteoarthritis: A Histochemical And Morphometric Study, Mark A. Glasberg, Janet R. Glasberg, Richard E. Jones

Henry Ford Hospital Medical Journal

We evaluated a series of 12 biopsies from 11 patients with total knee replacements for severe osteoarthritis. All 12 biopsies showed denervation atrophy, while five cases had significant myopathic changes. Morphometric studies indicated a positive atrophy factor (greater than 150) in the type I myofibers in seven cases, the IIA myofibers in nine cases, and the IIB myofibers in all 12 cases. Type I predominance occurred in six cases, IIA paucity in two cases, and IIB paucity in two cases. The results indicate that patients with severe osteoarthritis of the knee have both significant neuropathic and myopathic changes in quadriceps …

Catamenial Hemoptysis: A Case Report, Paul S. Harkaway, Michael S. Eichenhorn

Henry Ford Hospital Medical Journal

A young woman presented with recurrent hemoptysis temporally associated with menstruation. Catamenial hemoptysis, an extremely uncommon disorder, is usually caused by the presence of ectopic endometrial tissue within the lung. The use of progesterone suppressed menstruation and hemoptysis during four months of treatment. Chest x-ray was normal.

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Science Or Technology: A Challenge For Clinical Neurosciences, Stanton B. Elias

Henry Ford Hospital Medical Journal

No abstract provided.

Interventional Neuroradiology: Henry Ford Hospital Experience With Transcatheter Embolization Of Vascular Lesions In The Head, Neck, And Spine, Bharat A. Mehta, Clifford R. Jack Jr., Roushdy S. Boulos, Suresh C. Patel, James I. Ausman, Ghaus M. Malik

Henry Ford Hospital Medical Journal

Innovative developments over the past 15 years have resulted in increased sophistication and effectiveness of therapeutic neuroembolization procedures. As a result, percutaneous transcatheter embolization has assumed an increasingly important role in the management of patients with vascular lesions of the head, neck, and spine. By reducing bleeding during surgery, this technique can markedly facilitate the surgical approach to difficult vascular lesions. The technique may also be applied in cases where surgery is contraindicated. Therapeutic neuroembolization has been performed in 23 patients with vascular lesions of the head, neck, or spine at Henry Ford Hospital. Devascularization of the extraaxial blood supply …

The Effect Of Sta-Mca Bypass On Regional Cerebral Blood Flow In Ischemic Foci, Wendy M. Robertson, K. M. A. Welch, James R. Ewing, James I. Ausman, Fernando G. Diaz

Henry Ford Hospital Medical Journal

The effect of STA-MCA bypass on regional cerebral bloodflow (rCBF) is unclear Since asymmetries of rCBF have previously been shown to identify the focus of maximal cerebral ischemia, a study was performed to assess the effects of surgical revascularization on rCBF in this focus. Sixteen candidates for STA-MCA bypass were studied preoperatively and postoperatively. The rCBF vms measured by the '"Xenon inhalation technique with eight contralateral probe pairs. The probe pair with the maximal percentage difference in initial slope index (ISI) was identified and corresponded to the clinically involved hemisphere in 14 patients. Following surgery, the ISI increased in the …

Psychocardiologic Perspectives Of Coronary Artery Disease, Richard Ketai

Henry Ford Hospital Medical Journal

The importance of mind, emotion, and behavior as they relate to the heart, particularly coronary artery disease, is growing in recognition. A review of the research shows increasingly sophisticated demonstrations of links unifying heart function and mind. "Psychocardiology" would be an appropriate term for the diverse areas of interest which focus on the psychosocial correlates of heart disease. This paper illustrates this concept through a review of psychosocial and behavioral aspects of coronary artery disease.

Intussusception Of The Appendix And Endometriosis, Roberta E. Sonnino, Mohammed R. Ansari

Henry Ford Hospital Medical Journal

Intussusception of the appendix, though uncommon, is usually diagnosed during surgery. Endometriosis in an intussuscepted appendix is rarely described. A case of appendiceal intussusception of a rare morphologic type associated with endometriosis is presented, and the literature is briefly reviewed. Etiology, classification, and diagnosis are discussed.

Anti-Hla Antibodies Complicating Infectious Mononucleosis With Thrombocytopenia And Neutropenia, Warren L. Kupin, Maria Sawdyk

Henry Ford Hospital Medical Journal

A case concerning a 21-year-old male college student with thrombocytopenia and neutropenia complicating infectious mononucleosis is presented. Although the patient had no prior history of alloimmunization, a broad spectrum anti-HLA antibody was strongly positive in his serum. Concomitant with resolution of the hematologic abnormalities, the titer of the antibody diminished. This case is unique both in the severity of the thrombocytopenia and neutropenia and for the circulating HLA antibody most likely of viral origin.

Postinfarction Papillary Muscle Rupture: A New M-Mode Echocardiographic Sign, Dipankar S. Dasgupta, I. A. D'Cruz

Henry Ford Hospital Medical Journal

A 58-year-old man with acute inferior wall infarction developed a loud systolic murmur hypotension, and pulmonary edema four days after onset of infarction. M-mode echocardiography demonstrated an unusual diastolic echo that appeared between the mitral valve leaflets. Complete rupture of the posterior papillary muscle was confirmed at surgery for mitral valve replacement.

The Ec-Ic Bypass Study: Does It Answer The Question?, Fernando G. Diaz, James I. Ausman

Henry Ford Hospital Medical Journal

No abstract provided.

Biogenesis Of The Platelet Receptor For Fibrinogen: Evidence For Separate Precursors For Glycoproteins Iib And Iiia., Paul F. Bray, Jean-Philippe Rosa, Vishwanath R. Lingappa, Yuet W. Kan, Rodger P. Mcever, Marc A. Shuman

Cardeza Foundation for Hematologic Research

Congenital absence of platelet glycoproteins IIb and IIIa (GPIIb and GPIIIa) results in a severe bleeding disorder characterized by defective platelet aggregation and failure of fibrinogen to bind to platelets. GPIIb is a two-chain protein containing disulfide-linked alpha and beta subunits. GPIIb and GPIIIa are present as a heterodimeric, noncovalent complex in the platelet plasma membrane and function as the fibrinogen receptor. To characterize synthesis of these two proteins, RNA isolated from a human leukemia cell line that contains GPIIb and GPIIIa was translated in a wheat germ cell-free system. Polyclonal antibodies specific for each protein immunoprecipitated distinct [35S]methionine-labeled precursors, …

Low Toxicity Radiation Sensitizer, Barton L. Bergquist, James C. Chang

Patents (University of Northern Iowa)

This invention relates to cisplatin type fluorescently labeled compounds. In particular, the compounds are bis (5-aminofluorescein)-dichloroplatinum (II) or certain substituted analogues thereof. The compounds are useful as radiation sensitivity enhancers and as fluorescent biological tracers. The invention also relates to a unique, single step synthesis for preparing said compounds.

Early Soft Signs And Later Psychopathology, David Shaffer, Cornelius Stokman, Patricia A. O'Connor, Stephen Shafer, Joseph E. Barmack, Suzanne Hess, D. Spalten, Irvin Sam Schonfeld

Publications and Research

At age 17 two motor signs, mirror movements and dysdiadochokinesis, were found in more than half the subjects known to have had the respective signs at age 7. These rates were significantly higher than rates found within the group of subjects who were sign free at age 7.

Oncolog, Volume 31, Number 02, April-June 1986, Ralph S. Freedman Md, Phd, Elton Stubblefield Phd

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Conference Report: Gynecologic Cancer Outcome Improves Because of New Treatment Applications
• A Geneticist's View of Cancer: New Insight from Developmental Mechanisms
• Counseling, Practical Advice Help Women with Cervical Cancer Resume Sexual Activity

Oncolog, Volume 31, Number 03, July-September 1986, Staff

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Learning How and Why Drugs Kill Cells Is Chemotherapy Researchers' Prime Goal
• Cancer Prevention Begins at Home: With MDA Screening and Detection Clinic
• Grant Taylor Organized First Collaborative Drug Research Group in This Part of the Country

Oncolog, Volume 31, Number 01, January-March 1986, Lester J. Peters Md

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• From Ability to Measure Cell Survival Come New Radiotherapeutic Strategies
• Diagnosing the Rare Lesion: Ovarian and Omental Ependymomas
• Radiotherapy Tailored to Patient's Disease

Oncolog, Volume 31, Number 04, October-December 1986, Bruce M. Boman Md, Phd, Frances M. Davis Phd

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Hereditary Colon Cancer: Molecular Research and Family Studies Aim for Early Detection
• Bone Marrow Transplantation Success Brings Patients and Physicians to Reunion
• Houston-Galveston Hybridoma Researchers Review Laboratory and Clinical Progress

Vital Signs, Winter 1986, Boonshoft School Of Medicine

Vital Signs

A twenty eight page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

Intraocular Lens Implant Image Quality: The Optico-Retinal Interface, David D. Bogorad

Henry Ford Hospital Medical Journal

Improvements in intraocular lens implants during the past ten years have revolutionized cataract surgery. Both anterior and posterior chamber lenses are currently in wide use, but the optical superiority of the posterior chamber location has yet to be demonstrated. To do so, a more detailed analysis is required of visual function than is clinically routine. Also required is appreciation that the retina is an integral part of the eye's optical system because of its directional characteristics, which are known as the Stiles-Crawford effect. The optical quality of the pseudophakic eye is affected by the optics of the implant, its centration, …

Some Unusual Foreign Bodies In The Anterior Segment Of The Eye And The Orbit, Saul Sugar

Henry Ford Hospital Medical Journal

No abstract provided.

Glaucoma Filtration Surgery: A Personal Review, Saul Sugar

Henry Ford Hospital Medical Journal

No abstract provided.

Editorial: Corneal Stability With Rigid Gas Permeable Lens Refitting, Robert J. Crossen

Henry Ford Hospital Medical Journal

No abstract provided.

Malnutrition And Length Of Stay - A Relationship?, Marvin D. Anderson, Gladys Collins, Gloria Davis, Brack A. Bivins

Henry Ford Hospital Medical Journal

The admission nutrition status of 135 consecutive general medical patients admitted to a single nursing unit was evaluated using a simple questionnaire and available laboratory studies. A statistical analysis of the data obtained indicates that prolonged length of stay may be related to admission nutritional status.

Evaluation Of Peutz-Jeghers Syndrome In A Family, Kayhan Ozkan

Henry Ford Hospital Medical Journal

Five cases of Peutz-Jeghers syndrome in one family have been studied, and a review of the history and features of the syndrome are presented. This syndrome was detected in four of six siblings and in the father. Three family members underwent surgery after small-bowel obstruction was diagnosed. A gastric polyp was removed from a fourth family member. Rectal bleeding dominated the clinical picture in two patients. Colonic polyps were also found in the three patients who had small-bowel polyps. One of the four affected siblings had mucocutaneous pigmentation, but no evidence of intestinal polyps was detected. The five affected family …

Orbital Metastasis With Enophthalmos: A Review Of The Literature, David M. Reifler

Henry Ford Hospital Medical Journal

Orbital metastasis is associated with enophthalmos in up to one third of all cases. After analyzing the clinical and pathologic features In 25 reported cases of enophthalmic orbital metastasis, the condition was found to almost exclusively affect females, usually in the 60 to 70 age group. The right orbit was the most commonly affected. The primary lesion was located in the breast in 19 (76%) cases and in the abdomen in 6 (24%) cases. In one third of the cases, the manifestations of the orbital metastasis were recognized before diagnosing the primary lesion. The most common presenting features were diplopia …

Childhood Lead Poisoning, Raj P. Warrier, Jan Waisanen, Sam R. Kottamasu, Sayeed Sultana, K. Ratnakar Kini, William L. Kestenberg, John Strauthers, Craig Foreback

Henry Ford Hospital Medical Journal

Although lead encephalopathy is rare, lead intoxication continues to be a significant problem in Detroit. Neuropsychological effects may occur even at low levels of lead. Since treatment of lead poisoning consists of a painful series of injections, it is imperative that more attention be given to the prevention of this disease. To confirm the magnitude of the problems, our experience with lead poisoning during a three-year period at Henry Ford Hospital's Pediatric Department is reviewed.

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Immunocytologic Methods In The Diagnosis Of Orbital Tumors, David M. Reifler, Sudha R. Kini, John S. Kennerdell, Andrew Dekker, Leslie J. Fisher

Henry Ford Hospital Medical Journal

The pathologic diagnosis was supported or confirmed in three out of four cases that had an adequate cytologic specimen. The results demonstrate that adjunctive immunocytologic techniques can be used in combination with fine-needle aspiration for a variety of orbital tumors. The pathologic diagnosis was supported or confirmed in three out of four cases that had an adequate cytologic specimen. The results demonstrate that adjunctive immunocytologic techniques can be used in combination with fine-needle aspiration for a variety of orbital tumors.

Hereditary Sclerocornea, David Barsky, Steven P. Dunn

Henry Ford Hospital Medical Journal

A rare case of total hereditary sclerocornea is presented along with clinical history, histopathology, and a review of the possible pathogenesis and current literature on the subject. It is quite possible that imperfect cleavage of the anterior chamber angle may be the predisposing factor in scleralization of the cornea due to a failure of neural crest cell differentiation. If surgical intervention to correct for the corneal opacification is indicated, corneal transplantation should be performed as soon as possible after birth, similar to the indications for removal of dense congenital cataracts to avoid deprivation amblyopia.