Digital Commons Network^™

Current Concepts In The Diagnosis And Management Of Childhood Asthma, Z A. Bhutta

Department of Paediatrics and Child Health

No abstract provided.

Female Condoms, An Urgent Need, Mary Guinan

School of Public Health Faculty Research

As of February 1991, more than 16,000 cases of AIDS in women had been reported in the United States, but the ". tidal wave of cases in women is yet to come. World Health Organization (WHO) estimates of the number of women infected with the human immunodeficiency virus (HIV) range from 1.5 million in Africa to I 00,000 in the United States. Within the next ten years, the majority of these women will develop AIDS and die. Some will live a bit longer, but all are eventually doomed to die prematurely. Most will not live to see their 40th year.

Oncolog, Volume 36, Issue 03, July-September 1991, Emil J. Freireich Md, James M. Bowen Phd

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• From cell culture to clinical protocol: In cancer research, the goals of scientist and clinician converge New clinic treats depressed cancer patients
• Half-century of progress in leukemia research

Digest Of The Philadelphia College Of Osteopathic Medicine (Summer 1991), Philadelphia College Of Osteopathic Medicine

Digest

The Summer 1991 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• President's Perspective
• Two Highest Ranking Medical Officers Receive Honorary Degrees - Brig. Gen. Ronald R. Blanck & Rear Admiral Hugh P. Scott
• Second Career Dos are among PCOM's Outstanding Graduates
• Bright Future on the Horizon as Master Facility Plan Begins
• Tackling Tough Issues
• Osteopathic Medicine + Research = Challenging Career Path
• On Campus
• New Appointments
• Just Published
• Class Acts
• In Memoriam
• Coming Events

Preventative Oral Health Services Provided By Nurses' Aides To Nursing Home Residents, Deborah Lewis Hardy

Dental Hygiene Theses & Dissertations

The purposes of this investigation were to identify: 1) what preventive oral health services were provided by nurses' aides to nursing home residents, 2) how frequent preventive oral health services were performed by nurses' aides, 3) who nurses' aides reported abnormal or suspicious findings detected in the resident's mouth, 4) what factors discouraged and encouraged nurses' aides performance of oral health services, and 5) how nurses' aides rated their oral health knowledge of services they performed. The study population was comprised of a random sample of 40 percent of nursing home facilities in southeastern Virginia. A 14-item questionnaire was administered …

Department Of Radiology-Annual Report-July 1, 1990 To June 30, 1991, David C. Levin

Department of Radiology Administrative Documents and Reports

Department of Radiology Annual Report, July 1, 1990 to June 30, 1991. Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States. 84 pages.

Current Issues In The Leukemias, Howard R. Terebelo

Henry Ford Hospital Medical Journal

No abstract provided.

Antimicrobial Chemotherapy In The Intensive Care Unit, Louis D. Saravolatz

Henry Ford Hospital Medical Journal

No abstract provided.

Management Of Terminal Illness: The Hospice Concept Of Care, Josefina B. Magno

Henry Ford Hospital Medical Journal

No abstract provided.

Why Palliative Medicine?, Robert G. Twycross

Henry Ford Hospital Medical Journal

No abstract provided.

Predicting Survival In The Advanced Cancer Patient, Robert J. Miller

Henry Ford Hospital Medical Journal

No abstract provided.

Caring For The Terminally Ill: Communicating With Patients And Family, Dana G. Cable

Henry Ford Hospital Medical Journal

Caring for terminally ill patients requires effective communication skills. It is important that medical personnel understand appropriate ways to communicate with the patient in order to inform him about his illness, throughout its duration. Physicians must develop an understanding of how patients communicate and ways to respond to that communication. Furthermore, the physician needs to communicate with the family of the terminally ill patient. Effective communication must become a regular part of the treatment.

Chronic Myelogenous Leukemia: Molecule To Man, Robert Peter Gale

Henry Ford Hospital Medical Journal

Chronic myelogenous leukemia (CML) is the best understood human cancer. The molecular basis of CML involves activation of a cellular proto-oncogene—ABL. The consequence is to increase tyrosine kinase activity. This results in a marked clonal increase in the myeloid mass. Later on, cellular maturation is blocked and the decrease eventuates in acute leukemia. Abnormalities of other proto-oncogenes or antioncogenes, like P53, may be involved in leukemia progression. Treatment of CML involves chemotherapy and, more recently, interferon. Whether this treatment prolongs survival or increases the likelihood of cure is unknown but either result seems unlikely. Bone marrow transplants which cure about …

Application Of The Polymerase Chain Reaction For Detection Of Minimal Residual Disease Of Hematologic Malignancies, Mark S. Roth, Valeri H. Terry

Henry Ford Hospital Medical Journal

Current induction therapies for acute and chronic leukemias and the lymphomas have achieved significant complete remission rates. Despite this initial success, disease recurrence remains a major problem. Relapse from clinically undetectable residual malignant cells is the most likely mechanism of recurrence. Of crucial importance to the clinician is the accurate detection of residual malignant cells prior to clinical relapse. Standard approaches to evaluate for this minimal residual disease (MRD) allow detection only when the malignant clone exceeds 1%. Patients in remission, however, may frequently have residual neoplastic cells that are far below this level. Recently, several investigators have adapted the …

Assessment Of Methylprednisolone Purging Efficacy On Daudi Burkitt Lymphoma Cells From Normal Bone Marrow, Nalini Janakiraman, Loreen M. Niewenhuis

Henry Ford Hospital Medical Journal

Studies on normal bone marrow and Daudi Burkitt lymphoma cells were performed to determine the efficacy of selective, in vitro chemopurging with methylprednisolone (MP). We found that MP reduces the numher of lymphoma cells without significant damage to bone marrow cells. This information is important because we need to improve the existing in vitro purging regimens used to cleanse autologous marrows of metastatic disease before transplantation into cancer patients who have received high-dose chemotherapy. Normal human bone marrow (NBM) and Daudi lymphoma cells were trealed in parallel with various purging regimens. NBM death was evaluated using soft-agar culture, while Daudi …

Capsaicin: A Therapeutic Option For Painful Diabetic Neuropathy, Karen M. Basha, Fred W. Whitehouse

Henry Ford Hospital Medical Journal

Fifteen patients with diabetes mellitus who had painful diabetic neuropalhy (PDN) were enrolled in a double-blind study to test the safety and efficacy of capsaicin 0.075% (Axsain, Genderm, Northbrook, IL). Twelve of the 15 patients completed the eight-week sludy. Nine of the 12 patients reported symptomatic relief; of these nine, five used the drug and four used the vehicle. The three patients who reported no relief of symptoms applied the vehicle. Capsaicin is potentially effective when burning pain is a major symptom of PDN. The side effects of capsaicin were limited and minimal. This agent should be considered by clinicians …

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Quality Of Life: What Does It Mean?, Joyce A. Deshano

Henry Ford Hospital Medical Journal

No abstract provided.

Palliative Care In The 1990s: Special Issues, Derek Doyle

Henry Ford Hospital Medical Journal

No abstract provided.

New Purine Analogues For The Treatment Of Chronic B-Cell Malignancies, Thomas E. Gribbin

Henry Ford Hospital Medical Journal

Adenosine deaminase (ADA). a purine salvage pathway enzyme, appears to play a key role in normal lymphocyte growth, development, and differentiation. Three new purine nucleoside analogues, deoxycoformycin, fludarahine, and 2-chlorodeoxyadenosine, affect the normal function of the purine salvage pathway by inhibiting ADA or by acting as analogs of the ADA substrates. These agents show significant activity in the treatment of chronic B-cell leukemias and low-grade lymphomas. The pharmacology, mechanism of action, and clinical usefulness of these agents are discussed.

Peripheral Blood Stem Cell Transplantation As An Alternative To Bone Marrow Transplantation: An Overview, Nalini Janakiraman

Henry Ford Hospital Medical Journal

Stem cells capable of restoring hematopoiesis following lethal bone marrow injury circulate in the blood of many animals, including humans. When collected through leukapheresis and reinfused following high-dose chemotherapy, stem cells offer a treatment option not currently open to some patients who are unable to undergo autologous bone marrow transplantation because of tumor involvement in the pelvis, prior pelvic radiation, or intolerance to general anesthesia. After stem cell infusion, hematologic and immunologic recovery are rapid in comparison to that after autologous hone marrow reinfusion: however, in some cases platelet engraftment is slower. There is some evidence that tumor contamination in …

Porcine Bioprosthetic Aortic Valve Endocarditis With Ring Abscess And Aortic Stenosis, Reda A. Girgis, Howard Rosman, Ramon Del Busto, Maryann Fitzmaurice, Norman A. Silverman

Henry Ford Hospital Medical Journal

Porcine bioprosthetic valve endocarditis is an infrequent but serious complication of valve replacement surgery. Ring (or annular) abscess is a frequent finding in mechanical valve endocarditis. In contrast, porcine valve endocarditis most often involves the cusps, and annular infection is uncommon. Porcine valvular dysfunction secondary to endocarditis usually takes the form of incompetence, whereas stenosis is less frequent. We report a case of a 76-year-old female who developed endocarditis wilh Staphylococcus epidermidis nine months after placement of a Carpenter-Edwards porcine aortic valve. Her initial presentation included complete heart block and moderate aortic stenosis. Transesophageal echocardiography aided the diagnosis by demonstrating …

The Department Of Surgery And The Halsted Tradition, Edward R. Munnell

Henry Ford Hospital Medical Journal

No abstract provided.

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Hospice Care: An Overview, Josefina B. Magno

Henry Ford Hospital Medical Journal

No abstract provided.

The Use Of Corrected Occlusal X-Ray For Determination Of Ald : A Comparative Study, Merlin D. Ekvall

Loma Linda University Electronic Theses, Dissertations & Projects

In this study arch length discrepancy or ALD was studied in 50 untreated patients. The measurements obtained from Hilgers' corrected occlusal x-ray using his Occlusal Paralleling Instrument or O.P.I, were compared with those derived by four conventional methods, - "Eye balling," digital caliper determination, conventional mandibular x-ray, and the Rocky Mountain Data Systems computer analysis (31 cases). When using the OPI, results give a higher negative ALD as it takes into consideration the space required to level a curve of Spee.

Measurements were made by the author and 3 faculty members using the above methods. Statistical analysis of the means …

The Accuracy Of Sonographic Imaging (Dolphintm Digigraph) And Standard Lateral Cephalometric Radiographs : A Comparative Study, Michael D. Teichman

Loma Linda University Electronic Theses, Dissertations & Projects

Radiation due to x-ray exposure is a concern, and the development of the Dolphin™ DigiGraph represents an attempt to limit this exposure. The purpose of this paper was to compare measurements (using Ricketts analysis) obtained from conventional radiographic cephalometric tracings with those obtained by computerized digitizing with the DigiGraph. Forty-six patients from the Loma Linda University School of Dentistry graduate orthodontic clinic were digitized, and the results were compared to the x-ray tracings of these patients. The results showed that seven of the twenty-one variables examined exhibited a statistical similarity between the two methods (DigiGraph and x-ray tracing). An examination …

Effect Of Delays In Processing On The Survival Of Mycobacterium Avium-M. Intracellulare In The Isolator Blood Culture System., C. Fordham Von Reyn, Stephen Hennigan, Sandra Niemczyk, Nicholas J. Jacobs

Dartmouth Scholarship

Concentrations of Mycobacterium avium-M. intracellulare ranging from 10(-1) to 10(3) CFU/ml were added to blood, placed in Isolator tubes, and held at room temperature for intervals ranging from 4 h to 56 days before being processed (centrifugation and culture on Middlebrook 7H10 agar). At all concentrations tested, M. avium-M. intracellulare was recovered after hold times ranging from 4 h to 7 days; the number of final CFU actually increased progressively for hold times of 8 h or more. Hold times of up to 7 days did not increase the time from processing to the first appearance of visible colonies. At …

Efficient Immortalization Of Luminal Epithelial Cells From Human Mammary Gland By Introduction Of Simian Virus 40 Large Tumor Antigen With A Recombinant Retrovirus, Bartek J, Bartkova J, Kyprianou N, El-Nasir Lalani, Staskova Z, Shearer M, Chang S, Taylor Papadimitriou J

Department of Pathology and Laboratory Medicine

When defined in terms of markers for normal cell lineages, most invasive breast cancer cells correspond to the phenotype of the common luminal epithelial cell found in the terminal ductal lobular units. Luminal epithelial cells cultured from milk, which have limited proliferative potential, have now been immortalized by introducing the gene encoding simian virus 40 large tumor (T) antigen. Infection with a recombinant retrovirus proved to be 50-100 times more efficient than calcium phosphate transfection, and of the 17 cell lines isolated, only 5 passed through a crisis period as characterized by cessation of growth. When characterized by immunohistochemical staining …

Digest Of The Philadelphia College Of Osteopathic Medicine (Spring 1991), Philadelphia College Of Osteopathic Medicine

Digest

The Spring 1991 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• President’s Perspective
• A Role Model for the Profession
• Founders Day 1991 Highlights
• More News From the Gulf
• A Double Header:
• A Tale of Two
• Team Physicians
• “Tell Me Where It Hurts” - Students Refine Skills
• On Campus
• Alumni News
• Coming Events