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Articles 2611 - 2640 of 11074
Full-Text Articles in Entire DC Network
Trends In Trauma Patients With Psychiatric Illnesses, Sindhura Kompella, Kelly Mckenney, Clara Alvarez, Ilko Luque
Trends In Trauma Patients With Psychiatric Illnesses, Sindhura Kompella, Kelly Mckenney, Clara Alvarez, Ilko Luque
East Florida Division GME Research Day 2024
No abstract provided.
How Does Ect Treatment Affect The Chances Of Future Psychiatric Hospitalizations? A Retrospective Study, Aneesh Rahangdale, Joshua Wasdin, Jeffrey Ferraro
How Does Ect Treatment Affect The Chances Of Future Psychiatric Hospitalizations? A Retrospective Study, Aneesh Rahangdale, Joshua Wasdin, Jeffrey Ferraro
North Florida Division GME Research Day 2024
No abstract provided.
The Efficacy Of Botulinum Toxin Use In Service Members And Veterans With Migraine And Post-Traumatic Headache Disorders: A Scoping Review, Qing Zhao Ruan, Daniel J Pak, David E Reece, Rohan Jotwani, Sean Li, Moises Dominguez, Alan David Kaye, R Jason Yong, Abdulrazaq Albilali, Sadiq Bhayani, Jamal Hasoon, Michael E Schatman, Jun Beom Ku, Thomas T Simopoulos, Sait Ashina, Christopher L Robinson
The Efficacy Of Botulinum Toxin Use In Service Members And Veterans With Migraine And Post-Traumatic Headache Disorders: A Scoping Review, Qing Zhao Ruan, Daniel J Pak, David E Reece, Rohan Jotwani, Sean Li, Moises Dominguez, Alan David Kaye, R Jason Yong, Abdulrazaq Albilali, Sadiq Bhayani, Jamal Hasoon, Michael E Schatman, Jun Beom Ku, Thomas T Simopoulos, Sait Ashina, Christopher L Robinson
Faculty, Staff and Student Publications
Objective: To delineate the trend of use of botulinum toxin, including onabotulinum toxinA (OTA), in active military personnel and veterans with the diagnoses of migraine and post-traumatic headache (PTH) and describe the efficacy of botulinum toxin administration.
Background: Service members and veterans represent a unique population in the medical management of headache disorders, particularly migraine. They exhibit higher susceptibility to pain of greater intensity and longer durations, possibly due to their history of exposure to combat, trauma, and the associated psychological stresses. Given the burden and morbid nature of these headache disorders, prophylactic measures to reduce migraine attacks and disability …
Alternatives To The Squad Car: A Strategy Providing Hope For People With Mental Illness, Judy Ann Clausen, Joanmarie I. Davoli
Alternatives To The Squad Car: A Strategy Providing Hope For People With Mental Illness, Judy Ann Clausen, Joanmarie I. Davoli
UF Law Faculty Publications
Frontline healthcare providers and first responders have had enough of mental health care policy rooted in ideology and utopian visions instead of the practical realities of the nature of Serious Mental Illnesses (SMI). The current system of a severe shortage of mental health beds and strict criteria for administering mental health treatment in contravention of illness-induced treatment refusals has caused the real-world preventable tragedies of mass shootings, incarceration, homelessness, victimization, and death of people suffering from untreated SMI. Innovative programs and long-established protocols have been profiled by the media and examined by scholars. Momentum is brewing. Across the country, creative …
The Impact Of Workplace Stressors On Anxiety Levels And Mental Health Among Pediatric Intensive Care Nurses, Kelsey Ericah Ang
The Impact Of Workplace Stressors On Anxiety Levels And Mental Health Among Pediatric Intensive Care Nurses, Kelsey Ericah Ang
Nursing | Student Research Posters
Background: Pediatric Intensive Care Unit (PICU) nurses work in a high-stress environment where they are exposed daily to traumatic situations. The demanding emotional and physical challenges contribute to significant psychological burdens, including increased stress and anxiety. Purpose: The current paper proposes a research design to examine the outcomes of stress, anxiety levels, and mental well-being on PICU nurses when workplace support and structured debriefing sessions take place following a traumatic event. Methods: Participants will be recruited from PICU hospitals in Northern California. Participation will be voluntary, and informed consent will be obtained prior to the study. The selection criteria will …
The Education Prescription: Exploring The Potential Of Patient Education To Reduce Mental Health Issues In Hormonal Contraceptive Users, Maria Abraham
The Education Prescription: Exploring The Potential Of Patient Education To Reduce Mental Health Issues In Hormonal Contraceptive Users, Maria Abraham
Nursing | Senior Theses
The many birth control options available impact a woman’s life, as hormonal contraceptives are commonly used but often misunderstood. These contraceptives, which contain progestin only, or estrogen and progestin combined, can come in various forms such as pills, implants, IUDs, injections, the vaginal ring, and skin patches. They offer benefits such as reduced menstrual cramps and ectopic pregnancy risk. However, they may lead to adverse side effects which can include increased blood pressure, nausea, headaches, breakthrough bleeding, and a higher risk of blood clots, with research indicating a potential link between oral contraceptive use and a decline in the user’s …
Unleashing Wellness: Exploring The Impact Of Pet Therapy On Anxiety Reduction, Quality Of Life, And Treatment Adherence In Pediatric Oncology Patients, Karina Brouwer
Nursing | Senior Theses
Pet therapy is a complementary intervention that involves the interaction between a person and animal, with the focus of improving psychological well-being within diverse populations. In particular, children with oncological disorders have increases in anxiety and stress levels, therefore it is imperative to study the impact of animal interventions within this population. This literature critique explores the impact of pet therapy interventions on anxiety, stress, and quality of life perceptions in pediatric oncology patients. This research proposal will investigate how animal therapy interactions within pediatric oncology patients influence their anxiety levels and perceptions of quality of life and how these …
Advancing School Nursing Practice: A Novel Approach To Screening For Gastrointestinal Disorders In Children, Ashley Bunting, Isabella Cavlan
Advancing School Nursing Practice: A Novel Approach To Screening For Gastrointestinal Disorders In Children, Ashley Bunting, Isabella Cavlan
Nursing | Senior Theses
Background: Currently, mandated health screenings in California schools are limited to vision, hearing, and scoliosis; this leaves several other body systems unmonitored during the crucial years of childhood development. One such system is the gastrointestinal (GI) system, which plays a vital role in the normal growth, nutrition status, development, and overall health of children. Objective: By developing and implementing a GI-specific screening tool in the outpatient school setting, this research aims to increase the detection of GI disorders in children. Not only that, but school nurses can use this novel screening tool to promote early diagnosis, intervention, and …
Aligning Eye Care Provider Beliefs With Behaviors: Exploring And Improving Ocular Surface Disease Decision-Making In A Cataract Surgery Clinic, Amy Hellem
Communication (PhD) Dissertations
Millions of cataract surgeries are performed every year in the United States, yet both surgeon reports and patient reports indicate that practices are not utilizing the diagnostic tests and treatments that are advocated in the medical literature to identify and manage ocular surface disease prior to surgery. As a result, patients risk suffering several significant consequences with regard to their vision, comfort and safety. Personal observations from my 25 years of experience working with ophthalmologists and optometrists led to curiosity regarding the root cause of undertreatment of ocular surface disease. Specifically, I had the impression that eye care providers held …
Traditional Chinese Medicine: Employing Integrative Medicine As An Approach To Treat Cancer, Jade Hudson
Traditional Chinese Medicine: Employing Integrative Medicine As An Approach To Treat Cancer, Jade Hudson
CMC Senior Theses
This thesis explores the history of Traditional Chinese Medicine (TCM) through its depiction in the four classics of TCM and examines the evolution of the field to date. The five categories of TCM treatments analyzed in this paper include acupuncture, dietary therapy, herbal medicine, moxibustion, and physical exercise. Research highlights significant positive outcomes in cancer patients who incorporate TCM alongside modern cancer treatments, such as reduced nausea, vomiting, fatigue, anorexia, pain, and improvements in quality of life and overall well-being. However, notable risks associated with TCM herbal medicine and moxibustion underscore the need for further research into these practices before …
Understanding Primary Care Physician Perspectives On The Diagnosis And Management Of Non-Alcoholic Fatty Liver Disease: A Qualitative Study, Natalia I Heredia, Jemima C John, Sonia Singh, Jessica P Hwang, Larkin L Strong, Maya Balakrishnan, Lorna H Mcneill
Understanding Primary Care Physician Perspectives On The Diagnosis And Management Of Non-Alcoholic Fatty Liver Disease: A Qualitative Study, Natalia I Heredia, Jemima C John, Sonia Singh, Jessica P Hwang, Larkin L Strong, Maya Balakrishnan, Lorna H Mcneill
Faculty, Staff and Student Publications
Primary care physicians (PCPs) are well suited to manage patients with non-alcoholic fatty liver disease (NAFLD), but the limited, existing research suggests inadequate knowledge about the natural history, diagnostic methods, and management of NAFLD. The purpose of this qualitative study is to further understand the knowledge and practices for the diagnosis and management of NAFLD among PCPs. We conducted in-depth interviews with PCPs in the Greater Houston area, addressing current clinical practices used for diagnosing and managing NAFLD, as well as the perceptions of the PCPs regarding the burden of NAFLD on patients. We recorded interviews, transcribed them, coded transcripts, …
Physical And Psychosocial Factors Related To Firefighter Musculoskeletal Disorders, Jennifer Ellen Tinsley Kubala
Physical And Psychosocial Factors Related To Firefighter Musculoskeletal Disorders, Jennifer Ellen Tinsley Kubala
Theses and Dissertations--Rehabilitation Sciences
Career firefighters must perform physically and psychologically challenging duties in unpredictable and dangerous conditions. Previous investigations have found that firefighters suffer nearly 4 times the recorded musculoskeletal disorders (MSD) and workplace injuries compared to private and public sector workers, and take approximately 1.5 days longer to return to normal work. Thus, the burden of firefighter MSD experiences has been a growing area of exploration. The few investigations that have concurrently examined physical and psychosocial consequences experienced by firefighters have found a positive relationship between increased occupational stress reports and MSD experiences. However, these investigations, as well as those that individually …
Cffdna Screening For Niemann-Pick Disease, Type C1: A Case Series, Sydney A Lau, Romy I Fawaz, Robert Rigobello, Shahad Bawazeer, Nouf M Alajaji, Eissa Faqeih, Yanchun Li, Yanming Feng, Fan Xia, Christine M Eng, Malak Abedalthagafi
Cffdna Screening For Niemann-Pick Disease, Type C1: A Case Series, Sydney A Lau, Romy I Fawaz, Robert Rigobello, Shahad Bawazeer, Nouf M Alajaji, Eissa Faqeih, Yanchun Li, Yanming Feng, Fan Xia, Christine M Eng, Malak Abedalthagafi
Faculty, Staff and Students Publications
Cell-free fetal DNA (cffDNA) screening is a valuable tool in clinical practice for detecting chromosomal abnormalities and autosomal dominant (AD) conditions. This study introduces a novel proof-of-concept assay designed for autosomal recessive (AR) cffDNA screening, focusing on cases involving the NPC1 gene. We aim to illustrate the significant benefits of AR cffDNA screening in managing high-risk pregnancies, specifically where biallelic pathogenic variants in NPC1 cause Niemann-Pick disease, type C1 (NPC), a disorder marked by progressive neurodegeneration. Three participants for this study were recruited and gave consent to a hospital in Saudi Arabia. These participants were either carriers of NPC or …
Twelve Tips For Using The Understanding By Design® Curriculum Planning Framework, Alana D Newell, Cara A Foldes, Alison J Haddock, Nadia Ismail, Nancy P Moreno
Twelve Tips For Using The Understanding By Design® Curriculum Planning Framework, Alana D Newell, Cara A Foldes, Alison J Haddock, Nadia Ismail, Nancy P Moreno
Faculty, Staff and Students Publications
BACKGROUND: Health professions faculty engaged in curriculum planning or redesign can struggle with developing courses or programs that align desired learner outcomes, such as competencies to be applied in a clinical setting, with assessment and instruction.
AIMS: Our medical school implemented the Understanding by Design (UbD) framework to achieve alignment of outcomes, assessments and teaching during the renewal of our four-year curriculum. This article shares our strategies and practices for implementing UbD with teams of faculty curriculum developers.
DESCRIPTION: The UbD framework is a 'backward' approach to curriculum development that begins by identifying learner outcomes, followed by the development of …
Profile Of Caregiving Activities And Association With Physical Health Among Dementia Spousal Caregivers, Jinmyoung Cho, Laura P Sands, Alan B Stevens, Heather G Allore, Molly J Horstman
Profile Of Caregiving Activities And Association With Physical Health Among Dementia Spousal Caregivers, Jinmyoung Cho, Laura P Sands, Alan B Stevens, Heather G Allore, Molly J Horstman
Faculty, Staff and Students Publications
Background and objectives: This study aims to identify patterns of caregiving intensity and assess associations between caregiving intensity and multidimensional physical health indicators and health behaviors among spousal caregivers of persons with Alzheimer's disease and related dementia.
Research design and methods: Using data from 152 spousal caregivers aged 65 and older, the intensity of their caregiving experience was measured as the number and frequency of health- and medical-related helping activities for their care recipient. Multidimensional health indicators included self-reported fatigue, sleep disturbance, physical functioning, pain interference, general health, and the number of chronic conditions from the electronic health records. Self-reported …
How Users' Perceptions Of Friends' Content Influence Their "Annoyance" After Viewing Facebook Posts, Mai-Ly N Steers, Robert E Wickham, Olivia M Tabaczyk, Chelsie M Young, Michelle C Quist, Lindsey B Eikenburg, Jennifer L Bryan
How Users' Perceptions Of Friends' Content Influence Their "Annoyance" After Viewing Facebook Posts, Mai-Ly N Steers, Robert E Wickham, Olivia M Tabaczyk, Chelsie M Young, Michelle C Quist, Lindsey B Eikenburg, Jennifer L Bryan
Faculty, Staff and Students Publications
Social media posts may elicit strong, instantaneous feelings of irritation, or "annoyance." The current experiment investigated how participants' ratings of Facebook posts and their levels of closeness to the poster impacted these feelings. Respondents (N = 476) were asked to rate how irrelevant, inappropriate, mundane, and annoying Facebook posts from an imagined close friend, moderately close friend, and acquaintance were. A cross-classified, Bayesian structural equation model determined the unique contributions at the rater level, target level, and the distinct combination of rater and target at the within level. At the within level, results suggested irrelevance, mundaneness, and inappropriateness of posts …
A Pilot Study Of A Scalable Training Programme For Coaches Delivering Webstair, Sherry Yam, Jamie S Kim, Annapoorna Ayyagari, Julianna Hogan, Jan A Lindsay, Marylene Cloitre
A Pilot Study Of A Scalable Training Programme For Coaches Delivering Webstair, Sherry Yam, Jamie S Kim, Annapoorna Ayyagari, Julianna Hogan, Jan A Lindsay, Marylene Cloitre
Faculty, Staff and Students Publications
Background: Accessible, low-cost digital programmes are emerging as a means by which to address high rates of mental health problems. However, the development and assessment of scalable training programmes for effective use of digital interventions has lagged. This is particularly important, as coach-supported digital interventions provide benefits that substantially and consistently exceed those of programmes that are entirely self-guided.
Objectives: This report describes the evaluation of a brief coach training programme consisting of a two-hour workshop and six 1-hour consultation sessions for delivery of webSTAIR, a 10-module transdiagnostic web-based programme for trauma-exposed populations.
Method: The training was provided to 68 …
Nursing Care During Natural Disasters, War Zones, And Mass Casualty Incidents: Implications For An Educational And Professional Overhaul, Erin N. White
Undergraduate Honors Theses
Emergency situations around the world are inevitable. Any nurse who practices for any period of time is sure to encounter situations like these. Their hospital may be flooded with traumatic and severely life-threatening patient cases where supplies can become scarce. In these situations, a nurse and all other healthcare personnel are expected to act effectively, efficiently and in a highly organized way. Despite this need, many hospitals fail to implement effective disaster preparedness programs and plans. This leaves healthcare workers at a loss for how to treat patients, communicate within and outside of the hospital, coordinate transport, and all the …
Sociodemographic Correlates Of Low Health Literacy Skills Among Cancer Survivors: National Findings From Brfss 2016 And Implications For Precision Survivorship Care, Qi Chen, John Moore, Lailea Noel, Kirk Von Sternberg, Barbara Jones
Sociodemographic Correlates Of Low Health Literacy Skills Among Cancer Survivors: National Findings From Brfss 2016 And Implications For Precision Survivorship Care, Qi Chen, John Moore, Lailea Noel, Kirk Von Sternberg, Barbara Jones
Publications and Research
Purpose: This study aimed to explore associations of sociodemographic factors with difficulties in three health literacy (HL) skills and the severity of low HL skills.
Design: Cross-sectional secondary data analysis. Subjects: Data came from 17,834 adults who responded to the HL module with a response rate of 47% in the 2016 Behavioral Risk Factor Surveillance System.
Measures: Independent variables included sex, age, race/ethnicity, education, employment and income. Dependent variables are three HL skills: obtaining, understanding oral, and understanding written health information.
Analysis: We conducted weighted Chi-square tests and multinominal logistic regressions.
Results: Cancer survivors younger than 65 (aged 18-39: AOR=4.46, …
Detecting Cognitive Decline In High-Functioning Older Adults: The Relationship Between Subjective Cognitive Concerns, Frequency Of High Neuropsychological Test Scores, And The Frontoparietal Control Network, Justin E. Karr, Jonathan G. Hakun, Daniel B. Elbich, Cristina N. Pinheiro, Frederick A. Schmitt
Detecting Cognitive Decline In High-Functioning Older Adults: The Relationship Between Subjective Cognitive Concerns, Frequency Of High Neuropsychological Test Scores, And The Frontoparietal Control Network, Justin E. Karr, Jonathan G. Hakun, Daniel B. Elbich, Cristina N. Pinheiro, Frederick A. Schmitt
Neurology Faculty Publications
Objective: Neuropsychologists have difficulty detecting cognitive decline in high-functioning older adults because greater neurological change must occur before cognitive performances are low enough to indicate decline or impairment. For high-functioning older adults, early neurological changes may correspond with subjective cognitive concerns and an absence of high scores. This study compared high- functioning older adults with and without subjective cognitive concerns, hypothesizing those with cognitive concerns would have fewer high scores on neuropsychological testing and lower frontoparietal network volume, thickness, and connectivity.
Method: Participants had high estimated premorbid functioning (e.g., estimated intelligence ≥75th percentile or college-educated) and were divided based on …
Empirical Insights Into Survivorship Care: A Cross-Sectional Study Of Coc Accredited Hospitals In Kentucky, Amanda M. Beckett
Empirical Insights Into Survivorship Care: A Cross-Sectional Study Of Coc Accredited Hospitals In Kentucky, Amanda M. Beckett
Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)
ABSTRACT
Background:
Cancer survivorship care programs play a vital role in supporting cancer survivors and improving their quality of life. Understanding the landscape of survivorship and the potential barriers is key to optimizing care delivery.
Methods:
The primary purpose of this cross-sectional study was to explore existing cancer survivorship care programs offered by Commission on Cancer (CoC) accredited hospitals in Kentucky. Data from the Markey Cancer Affiliate Network (MCCAN) from 2022 through 2023 was analyzed. Variables included hospital characteristics such as rural code, types of survivorship services offered, and reported barriers to these services.
Results:
Analysis of n=19 CoC facilities …
Unleashing Wellness: Exploring The Impact Of Pet Therapy On Anxiety Reduction, Quality Of Life, And Treatment Adherence In Pediatric Oncology Patients, Karina Brouwer
Nursing | Student Research Posters
Pet therapy is a complementary type of therapeutics in which a person and animal have a guided interaction with the purpose of helping someone cope with physical and/or mental illness. Animal-assisted therapy is used in numerous settings and has been shown to reduce stress, lower blood pressure and heart rate, and decrease anxiety and depression (Husson University, 2022). In particular, pediatric oncology patients have enormous amounts of stress in their lives, which leads to increased anxiety and decreased quality of life (Children's Cancer Cause, 2023). While evidence shows that integrating pet therapy in pediatric oncology patients produces significant benefits on …
The Critical Role Of External Involvement In Supporting Adolescent Mothers Facing Postpartum Depression, Samantha Campopiano
The Critical Role Of External Involvement In Supporting Adolescent Mothers Facing Postpartum Depression, Samantha Campopiano
Nursing | Student Research Posters
Postpartum depression (PPD) can occur in mothers after birth. PPD affects one in seven women during their first year of postpartum. PPD does not have a definitive cause, but underlying contributions include hormonal changes, metabolic pathway changes, and a new onset of stressors. After birth, the drop in estrogen and progesterone levels can trigger or worsen the depressive episodes seen in PPD. PPD risk factors encompass the following determinants: psychological, obstetric, social, lifestyle, and family history (Carlson et al., 2024). Postpartum depression is more common in adolescents than adult mothers (Phipps et al., 2013). Research shows adolescents who don’t have …
Evidence Synthesis Methodology: Promoting Reproducible Methodology Through Modified Assignments, Laura Lipke, Neyda Gilman
Evidence Synthesis Methodology: Promoting Reproducible Methodology Through Modified Assignments, Laura Lipke, Neyda Gilman
Library Created Resources
Initially, systematic reviews in healthcare served to synthesize findings from clinical studies, aiding comprehensive access to the most effective treatments within evidence-based practice. Over time, their scope has broadened beyond treatment effectiveness, leading to a surge in publication. Consequently, many health science faculty now assign systematic reviews in classrooms without a full grasp of the standardized process, leaving students ill-equipped due to insufficient guidance and resources.
While mastering systematic review techniques is crucial for evidence-based practice, faculty can opt for modified assignments to foster a deeper understanding of the review process. These modified tasks, can be completed within a semester, …
Health Consequences Of Racial Disparity In Access To Abortion: A Systematic Review, Lacy M. Frye, Calvin Odhiambo
Health Consequences Of Racial Disparity In Access To Abortion: A Systematic Review, Lacy M. Frye, Calvin Odhiambo
University of South Carolina Upstate Student Research Journal
Prior to the 2022 Dobbs decision, Black women already experienced negative maternal health outcomes at an alarmingly disparate rate in comparison to White women. Given that the Dobbs decision emboldens state power to enforce abortion restrictions or protections, there has been significant strides made in both directions. Nonetheless, within states where reproductive rights have been significantly eroded, the heightened abortion restrictions may compound the limited access that Black women previously had before Dobbs. This, in turn will exacerbate the already disparate negative maternal outcomes that Black women experience. However, research on the relationship between the lack of access to abortion …
Using The Electronic Medical Record To Improve Nurse Workload, Sharon C. Le Roux
Using The Electronic Medical Record To Improve Nurse Workload, Sharon C. Le Roux
Doctor of Nursing Practice (DNP) Scholarly Projects - Archive
Background
Equitable nurse-patient assignments have been associated with improved nurse well-being, patient satisfaction and outcomes. Despite this, in an academic medical center in the southwestern United States, there is no standardized process to create equitable nurse-patient assignments.
Objectives
The aim of this project was to improve inpatient oncology nurse well-being and satisfaction through the implementation of an EMR based nurse-patient assignment tool.
Methods
The IOWA Model-Revised for evidence-based practice was used as the basis for this project. Data collected included demographics, the Well-Being Index Survey, perception of satisfaction with manual workload tool, along with knowledge and use of the …
Obesity Management Guideline For The Correctional Setting, Rumi Y. Sato
Obesity Management Guideline For The Correctional Setting, Rumi Y. Sato
Doctor of Nursing Practice (DNP) Scholarly Projects - Archive
Obesity can cause multiple chronic conditions, including cancer and death. Los Angeles jail primary care clinics do not address obesity management despite health hazards, rising costs, and high obesity rates in correctional facilities. The Centers for Medicare and Medical Services (CMS) obesity-management guidelines are over ten years old and outdated. The aim of this Doctor of Nursing Practice (DNP) project was to update the CMS obesity-management guideline with the newest intense behavioral therapy (IBT) evidence to assist the correctional multidisciplinary healthcare team. This project took place in a Los Angeles correctional facility's primary care clinic. A detailed literature review gathered …
Developing Toolkit For Adults With Autism Spectrum Disorder In An Oncology Outpatient Clinic, Brittany J. Johnson Dnp, Fnp-C
Developing Toolkit For Adults With Autism Spectrum Disorder In An Oncology Outpatient Clinic, Brittany J. Johnson Dnp, Fnp-C
Doctor of Nursing Practice (DNP) Scholarly Projects - Archive
Autistic adults are at higher risk of being diagnosed with co-occurring health conditions, and yet they are a vulnerable group for disparities in access and outcomes. One of the key barriers to better outcomes is poor patient-provider communication. This study the use of AASPIRE’s AHAT communication toolkit as a channel between healthcare workers and autistic adults to facilitate their appointments within the outpatient oncology department, as well as assessing healthcare providers’ knowledge and self-efficacy in caring for the patients. Sixteen healthcare providers (12 registered nurses and four patient care assistants) completed pre and post intervention surveys and utilized the AHAT …
Glutamate Optimization As A Treatment For Depression: A Clinical Guideline, Luisa Angeles Collins Villares
Glutamate Optimization As A Treatment For Depression: A Clinical Guideline, Luisa Angeles Collins Villares
Doctor of Nursing Practice (DNP) Scholarly Projects - Archive
Based on the use of drugs to treat hypertension and tuberculosis for depression, the monoamine hypothesis led to the development of antidepressants in 1952. Serotonin was recognized as a deficiency associated with depression in 1967. As a fine-tuning orchestration of neurotransmitters and neuromodulators, the glutamate system became known using Spravato in 2019 and Auvelity in 2022. In this pilot study, mental health experts rated the importance of 24 science-based recommendations to optimize glutamatergic therapy in depression for a proposed guideline on a Likert scale from zero to four. The results were analyzed using a non-parametric predictive modeling method called Chi-Square …
Repolarizing Tumor-Associated Macrophages In Ovarian Cancer: A Novel Immunotherapeutic Approach, David Schweer
Repolarizing Tumor-Associated Macrophages In Ovarian Cancer: A Novel Immunotherapeutic Approach, David Schweer
Theses and Dissertations--Clinical and Translational Science
Ovarian cancer, recognized for its high lethality and resistance to conventional immunotherapies, mandates innovative strategies to confront its intricate challenges. The tumor microenvironment (TME), orchestrated by tumor-associated macrophages (TAMs), assumes a pivotal role in disease progression, rendering TAMs an appealing therapeutic target. This study endeavors to explore the prospect of repolarizing TAMs from a protumor M2 phenotype to an antitumor M1 state, employing M1 macrophage-derived vesicles (MEVs) as a groundbreaking immunotherapeutic approach.
The primary objective is to investigate the capacity of M1 MEVs to repolarize M2 macrophages in vitro towards an anti-tumor M1-like phenotype. By inducing human macrophages to adopt …