Digital Commons Network^™

Microbiota, Metabolic Profiles And Immune Biomarkers In Infants Receiving Formula With Added Bovine Milk Fat Globule Membrane: A Randomized, Controlled Trial, Chloe Christensen, Car Reen Kok, Cheryl L. Harris, Nancy Moore, Jennifer L. Wampler, Weihong Zhuang, Steven S. Wu, Robert Hutkins, Jacques Izard, Jennifer M. Auchtung

Journal Articles: Internal Medicine

INTRODUCTION: Few studies have evaluated the effects of milk fat globule membrane (MFGM) on microbiota and immune markers in early infant nutrition.

METHODS: In this double-blind randomized study, infants (7-18 days of age) received either bovine milk-based infant formula (Control) or similar formula with an added source (5 g/L) of bovine MFGM (INV-MFGM) for 60 days. A reference group received mother's own human milk over the same period (HM). Oral and stool samples were collected (Baseline and Day 60) to evaluate microbiota, immune markers, and metabolites.

RESULTS: At Day 60, stool bacterial diversity and richness were higher in formula groups …

Seroprevalence Of Hiv Markers Among Patients Attending To Shebin El- Kom Teaching Hospital, Elham T. Awwad, Rasha G Mostafa, Asmaa M Soliman, Abdelghany Aish, Mariam A. Fouad

Journal of Medicine in Scientific Research

Objectives: to determine the prevalence of HIV infections and assess the accuracy of various testing methods among patients at Shibin El Kom teaching hospital.

Background: HIV/AIDS is a global public health challenge, with increasing prevalence in developing countries like Egypt. Stigma and limited detection methods have hindered the accurate assessment of HIV cases. Early detection is critical for effective prevention and treatment.

Methods:

A retrospective study was conducted from May 2006 to December 2022, involving 71,353 individuals who underwent routine preoperative and preadmission investigations. Blood samples were collected and tested using an immunochromatographic rapid test, ELISA, chemiluminescence, and Western blot. …

Association Between Urolithiasis And Non-Alcoholic Fatty Liver Disease ; A Comprehensive Study In National Institute Of Urology And Nephrology, Jehan Ibrahim M. Altohamy, Basma Aref Eltaweel, Ahmed Mostafa Elgamal, Salwa Mohammed Ahmed Dahesh, Ghadir Mohamed Elsawy

Journal of Medicine in Scientific Research

Background: Numerous studies have documented an important association between non-alcoholic fatty liver disease (NAFLD) and urolithiasis. NAFLD is described as 5% fat or more of the liver contents in other liver diseases absence including those related to alcohol consumption, chronic viral hepatitis, other chronic liver diseases as autoimmune hepatitis, and drug-induced hepatic diseases (1). Liver tru-cut biopsy is considered the gold standard yet invasive NAFLD diagnostic technique and carries potential complications (2). On the other hand, Computed Tomography (CT) is considered a non-invasive convenient tool that allows for measurable assessment of NAFLD allowing for quantitative diagnosis. Consequently, CT has proven …

Metabolism Shapes Immune Responses To Staphylococcus Aureus., Prabhakar Arumugam, Tammy Kielian

Journal Articles: Pathology and Microbiology

BACKGROUND: Staphylococcus aureus (S. aureus) is a common cause of hospital- and community-acquired infections that can result in various clinical manifestations ranging from mild to severe disease. The bacterium utilizes different combinations of virulence factors and biofilm formation to establish a successful infection, and the emergence of methicillin- and vancomycin-resistant strains introduces additional challenges for infection management and treatment.

SUMMARY: Metabolic programming of immune cells regulates the balance of energy requirements for activation and dictates pro- versus anti-inflammatory function. Recent investigations into metabolic adaptations of leukocytes and S. aureus during infection indicate that metabolic crosstalk plays a crucial role in …

Antimicrobial Activity Of Gallium(Iii) Compounds: Pathogen-Dependent Targeting Of Multiple Iron/Heme-Dependent Biological Processes, Seoung-Ryoung Choi, Mohammed A. Hassan, Bradley E. Britigan, Prabagaran Narayanasamy

Journal Articles: Pathology and Microbiology

Metals play vital roles in biological systems, with iron/heme being essential for cellular and metabolic functions necessary for survival and/or virulence in many bacterial pathogens. Given the rise of bacterial resistance to current antibiotics, there is an urgent need for the development of non-toxic and novel antibiotics that do not contribute to resistance to other antibiotics. Gallium, which mimics iron, has emerged as a promising antimicrobial agent, offering a novel approach to combat bacterial infections. Gallium does not have any known functions in biological systems. Gallium exerts its effects primarily by replacing iron in redox enzymes, effectively inhibiting bacterial growth …

A Mindfulness Approach To Regulate Depressive-Associated Emotional Eating, Jillian G. Montefusco

Doctor of Nursing Practice Scholarly Projects

Background: Depression affects 350 to 500 million people globally, with depressive-associated emotional eating (DAEE) impacting approximately 43.5% of these individuals. Depressive-associated emotional eating contributes to obesity through poor dietary choices and weight gain, leading to the projection that by 2048 all United States citizens will be overweight or obese.

Local Problem: At a Chicago weight loss center, the Emotional Appetite Questionnaire screened 75 patients, revealing that 56% (N = 42) ate more during sadness, boredom, and loneliness, and 50.7% (N = 38) ate more during depression, indicating significant DAEE.

Methods: This quasi-experimental quality improvement project uses a pre- and post-evaluation …

Standardizing The Discharge Process To Reduce Copd Readmission Rates, Kristine Doligosa

Doctor of Nursing Practice Scholarly Projects

Background: Frequent acute exacerbations of chronic obstructive pulmonary disease (AECOPD) can lead to unfavorable patient outcomes and costly readmissions. Inadequate patient support during discharge and an inconsistent discharge process are factors contributing to high readmissions in this population.

Purpose: This quality improvement project aimed to reduce COPD-related hospital readmissions by standardizing the discharge process for patients admitted with AECOPD and identify patient risk factors for readmission.

Methods: Following a quantitative and quasi-experimental design, this project standardized the discharge process for patients admitted with AECOPD using the Re-Engineered Discharge Toolkit components and a discharge care bundle. The project was …

A Guide To Pediatric Wellness Through Utilization Of Dragon Commands, Prasad Munusamy, Parisa Biazar, Jacob Trimble, Anthony Shadiack

South Atlantic Division GME Research Day 2024

No abstract provided.

An Interesting Case Of Modern Day Scurvy, Petar Jen, Jessica Cook, Elise Clark, Laurence Dubensky

East Florida Division GME Research Day 2024

No abstract provided.

Biotin For Hair Loss: Teasing Out The Evidence, Allyson Yelich, Hannah Jenkins, Sara Holt, Richard Miller

West Florida Division GME Research Day 2024

No abstract provided.

Osteopathic Manipulative Treatment (Omt) Utilization In The Primary Care Setting, Ceferino Cruz, Afsha Rais

North Texas GME Research Forum 2024

INTRODUCTION: Osteopathic Manipulative Treatment (OMT) is a skillset used to help diagnose and treat patients with a wide range of musculoskeletal complaints and can also be used as adjunctive treatment modalities for other organ systems. The project is designed to increase OMT usage across 3 clinical sites in our residency program to improve the quality of care provided to our patients. OBJECTIVES: Integrate OMT review into longitudinal clinical education. Address the shortage of faculty members that can precept OMT across all three sites. METHODS: The metrics being tracked are various OMT CPT codes ranging from 98925 to 98929 …

Type Ii Diabetes And Keto Diet In Family Medicine Clinic: A Case Report, Dante Paredes, Karos Torres, Joshua Moton

North Texas GME Research Forum 2024

The management of patients with high cardiac risk profiles who require insulin therapy for diabetes can be challenging due to the potential adverse effects of insulin on cardiovascular health. In order to achieve remission of type 2 diabetes mellitus (T2DM) and discontinue the need for insulin, weight loss has long been recognized as a valuable approach. The goal for this case was to implement dietary and lifestyle changes in a safe and efficient manner to induce remission of T2DM, without increasing the sympathetic load often associated with fully dosed ketogenic and other fasting strategies. This case report highlights the successful …

Hypothyroid: New Insights On An Old Disease, Sara Ward

Graduate Research Projects

No abstract provided.

Devastating Cerebral Injury Prior To Dka Therapy -Case Report, Brittany Bare, Chandler Sapp, Evelyn Fagan, Sunil Keshwah

South Atlantic Division GME Research Day 2024

No abstract provided.

Safety And Efficacy Of Peptide Receptor Radionuclide Therapy In Neuroendocrine Tumors: A Single Center Experience., Vineeth Sukrithan, Heather Armbruster, Sherise Rogers, Sherry Mori Vogt, Cassandra Grenade, Claire Verschraegen, Ye Zhou, Ashima Goyal, Mona Natwa, Akram Hussein, Hallie Barr, Dramane Konate, Rochelle Batdorf, Andrew Brown, Bonnie Williams, Songzhu Zhao, Lai Wei, Menglin Xu, Manisha H Shah, Bhavana Konda

Oncology Articles

Peptide receptor radionucleotide therapy (PRRT) with 177Lu-dotatate is widely used for the treatment of patients with neuroendocrine tumors (NETs). We analyzed data from 104 patients with NETs treated with 177Lu -dotatate at a US academic center between December 2017 and October 2020 to better understand patterns of long-term efficacy, safety, and toxicity in the real-world setting. 177Lu-dotatate (200 mCi) was administered every eight weeks for four doses. The most common sites of primary disease were small intestine NETs (n = 49, 47%), pancreatic NETs (n = 32, 31%), and lung NETs (n = 7, 7%). Twenty-seven percent had Ki-6720%. The …

Cancer Care Annual Report 2022-2023, Children's Mercy Kansas City

Cancer Center Annual Reports

Annual report of cancer care and oncology services at the Children's Mercy Kansas City, a pediatric medical center. This year’s report focuses on Brain Tumors.

Children's Mercy Annual Report 2023, Children's Mercy Kansas City

Children's Mercy Annual Reports

Annual report for Children's Mercy Kansas City in Kansas City MO, a pediatric medical center.

Research Annual Report Fy2024, Children's Mercy Kansas City

Research Annual Reports

Annual report of the research at Children's Mercy Kansas City in Kansas City MO, a pediatric medical center.

To Have And To Not Hold: Long-Acting Insulin For Npo Patients With Diabetes, William Hicks, Cindy Iwuagwu, Suzan Khalil, Juan Pablo Meruvia Garron, Cynthia Schwartz, Carlos Botero Suarez, Ashwini Komarla, Mustafa Kinaan

North Florida Division GME Research Day 2024

No abstract provided.

Improving Documentation Of Patients' Physical Activity In The Outpatient Setting, Jordan Price, Syed Abbas, William Bass, Rigoberto Hernandez, Abdullah Shuaib, Michele L. Mccarroll, Lindsay Porter

North Texas GME Research Forum 2024

Background: There is vast data on the health benefits of physical activity (PA) and the serious health consequences that are associated with a sedentary lifestyle. Research suggests that physicians who have meaningful conversations about exercise with their patients can be effective at increasing their patients' PA. In order to measure the effects of these discussions, the clinician must be able to document the baseline and subsequent PA of their patients. Our project seeks to improve the assessment and documentation of patient PA. Methods: Using Plan-Do-Study-Act (PDSA) quality improvement methodology, a multidisciplinary team was created to identify ways to improve documentation …

Retrospective Study: Adverse Effects Of Hyperglycemia In Nondiabetic Critically Ill Patients With Myocardial Infarction, Enkhbileg Batbileg, Jourdan Harper, Daniel Moore, Carol Wang, Sarah Barraza

Central & West Texas GME Research Day 2024

No abstract provided.

Improvement Of Diabetes Mellitus Management In A Resident-Run Clinic By Using Continuous Glucose Monitoring (Cgm), Janet Tam, Nathan Holt, Rakahn Haddadin, Ranier Rivera, Yasra Badi, Esar Dini, Andrey E. Manov

Far West Division GME Research Day 2024

No abstract provided.

Case Report: Special Considerations When Initiating Insulin In A Non-English-Speaking Patient With Diabetes: A Social Guide For New Insulin-Prescribing Residents, Jacob Uskavitch, Seth Barker

TriStar Division GME Research Day 2024

No abstract provided.

A Case Report In Hyponatremia As The First Presentation Of Stage Iv Lymphoma; An Opportunity For Earlier Diagnosis, Kathleen Rowe

TriStar Division GME Research Day 2024

No abstract provided.

Squamous Cell Carcinoma Of The Oral Cavity During Intubation, Cherry Liu, Amanda Sniadach, Michael Dinh, Christian Park, Rodd Rezvani

Far West Division GME Research Day 2024

No abstract provided.

Pregnancy Outcome In Assisted Reproductive Technology Pregnancy Complicated By 46 Day Preterm Prelabor Rupture Of Membranes, Type 2 Diabetes Mellitus And Severe Preeclampsia, A Case Report, Dana Rei Cassab, Alexis O'Connell, Maral Darya

East Florida Division GME Research Day 2024

No abstract provided.

Risks And Benefits Of Continuing Metformin During Hospitalization, Joel Speir, Sean Shearan, Kevin Trappett, Elizabeth Uba, Kenneth Krell

Continental, MidAmerica, & Mountain Divisions GME Research Day 2024

No abstract provided.

A Case Of Wernicke's Encephalopathy Due To Cannabinoid Hyperemesis, Jake Allinson, Ryan Bradbury, Paul Stanford

Continental, MidAmerica, & Mountain Divisions GME Research Day 2024

No abstract provided.

Pharmacoepidemiology Of Glp-1 Receptor Agonists, Nicholas E. Woessner

Continental, MidAmerica, & Mountain Divisions GME Research Day 2024

No abstract provided.

Relationship Between Genotype And Disease Phenotype For Gluten-Related Disorders, Michael Roberts, Nadine Grzeskowiak, Stephen Bricher

Faculty Publications

We investigated gluten-related disorders (GRD) in intestinal biopsy-proven subjects to determine the relation between genotype (i.e., Human Leukocyte Antigen (HLA) DQ alleles) and phenotype (i.e., antibody levels and clearly defined symptoms). Subjects had known DQ genotypes, information on IgA anti-Endomysial antibodies (EMA) and/or anti-tissue Trans Glutaminase (tTG) antibodies (tTGA). Subjects also answered a survey characterizing gastrointestinal, skin, and neural symptoms. Though all were biopsy-proven, HLA genotypes included all combinations of DQ2.5, DQ2.2, DQ8, DQ7.5, DQ5, and DQ6. Subject antibody levels were proportional to the number of DQ2.5 haplotypes, and subjects with non-CD-associated haplotypes did not have positive antibody scores (despite …