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Elevated Expression Of Type Vii Collagen In The Skin Of Patients With Systemic Sclerosis. Regulation By Transforming Growth Factor-Beta., Lidia Rudnicka, John Varga, Angela M. Christiano, Renato V. Iozzo, Sergio A. Jimenez, Jouni Uitto

Department of Dermatology and Cutaneous Biology Faculty Papers

A hallmark of systemic sclerosis (SSc) is the development of tissue fibrosis. Excessive production of several connective tissue components normally present in the dermis, including type I, III, V, and VI collagens as well as fibronectin and proteoglycans, is a consistent finding in the skin of SSc patients. Type VII collagen is a major constituent of anchoring fibrils, present in the skin at the dermal-epidermal basement membrane zone. TGF-beta has been shown to upregulate the expression of the type VII collagen gene. In this study, we assessed the expression of type VII collagen and TGF-beta in the skin of patients …

Immunologic Evaluation Of Ectopic Gestation, Tawfig Amin Nasser

Health Services Research Dissertations

Ectopic gestation is an error in the implantation site of the blastocyst. Extrauterine implantation presents a unique environment since the protective features of the uterus are absent. This study is an investigation into the immunoregulatory differences that may develop as a result of a change in the feto-maternal junction.

The effects of female plasma on one-way mixed lymphocyte cultures and mitogen-stimulated cultures, anti-paternal lymphocytotoxicity, and lymphocyte phenotypes were determined on normal, ectopic and non-pregnant females. The results indicated that pregnant female plasma enhanced the response of autologous lymphocytes to spouse and male control lymphocytes. Enhancement was not seen in the …

Amoebic Appendicitis--A Rare Entity, Raheem Ahmed, Hizbullah Shaikh, Muhammad Siddiqui, M Ahmed

Department of Pathology and Laboratory Medicine

Appendectomy is the most common surgical procedure performed in routine general surgical practice. However, not all the appendices removed, are submitted for histopathological examination in this part of the world. We reviewed 1400 appendices received by our department from within our hospital and from outside the hospital. Of these 13 cases were reported as amoebic appendicitis. These patients did not have any different clinical presentation from the patients who were reported as acute appendicitis without amoebae. Microscopically these appendices had minimal neutrophil polymorph infiltration accompanied by tissue necrosis and amoebic trophozoites within the appendiceal wall. After histological diagnosis, different tests …

Possible Roles Of Insulin And Insulin-Like Growth Factors In Rat Preimplantation Development: Investigation Of Gene Expression By Reverse Transcription-Polymerase Chain Reaction., X Zhang, G M Kidder, A J Watson, G A Schultz, D T Armstrong

Obstetrics & Gynaecology Publications

The sensitive mRNA phenotyping technique of reverse transcription-polymerase chain reaction was used to demonstrate that insulin receptor mRNA is present in rat embryos during the preimplantation period. In addition, mRNA encoding insulin-like growth factor (IGF) type I and type II receptors have also been detected in rat preimplantation embryos. IGF-I mRNA was not detected in preimplantation embryos but was found in oviducts and uteri of prepubertal and early pregnant rats. IGF-II mRNA was present in both embryos and in oviducts and uteri during the preimplantation period. These findings suggest that insulin and IGF-I could influence early embryo development in endocrine …

Conjoined Twins - A Review Of Literature With Two Case Studies, Naaeem Uz-Zafar Khan, Nadeem Ullah Khan, Khalid Matin, Adnan Zaidi

Department of Emergency Medicine

Two cases of conjoined twins have been reported. A review of literature is given.

Malakoplakia Of The Uterus, H Shaikh, P E. Khan, N Faridi

Department of Pathology and Laboratory Medicine

No abstract provided.

Endobronchial Tuberculosis Simulating Bronchial Asthma, J A. Khan, N Islam, J Akhter, S F. Hussain

Section of Pulmonary & Critical Care

No abstract provided.

Laparoscopic Appraisal Of Infertility And Pelvic Pain In Pakistani Women: A 5 Years Audit, R Hamid, K S. Khan, T Mubeen, J A. Razzak

Department of Obstetrics & Gynaecology

Five hundred and nine Laparoscopic examinations performed between 1987-91, (147 procedures for evaluation of gynaecologic pelvic pain and 313 for infertility) revealed ectopic pregnancy (27%), twisted ovarian cyst (18%) and acute pelvic inflammatory disease (14%) in cases of acute gynaecologic pain, and endometriosis (17%) and chronic pelvic inflammatory disease (16%) in chronic pelvic pain. Adhesions (20%), tubal block (15%), endometriosis (9%) and polycystic ovary (7%) were common findings in cases of infertility. These data support the usefulness of this minimally invasive procedure in accurate diagnosis of gynaecological disorders and provides insight into the spectra of diseases seen in Pakistani women …

Optical Properties Of Human Uterus At 630 Nm, Steen J. Madsen, Bruce J. Tromberg, Yona Tadir, Pius Wyss, Lars O. Svaasand, Richard C. Haskell

All HMC Faculty Publications and Research

The optical properties of normal and fibriotic human uteri were determined using frequency-domain and steady-state techniques .

Expression And Function Of Fgf-4 In Peri-Implantation Development In Mouse Embryos, Daniel A. Rappolee, Claudio Basilico, Yogesh Patel, Zena Werb

Department of Obstetrics and Gynecology Research Publications

One of the earliest events in mammalian embryogenesis is the formation of the inner cell mass (ICM) and the subse- quent delamination of primitive endoderm. We have found that mRNA for fibroblast growth factor (FGF)-4, but not FGF-3, is expressed in preimplantation mouse blastocysts and that the FGF-4 polypeptide is present in ICM cells. ICM-like embryonal carcinoma cells and embryonic stem cells also express FGF-4. Conversely, differentiated embryonal carcinoma cells in the endoderm lineage express FGF-3, but not FGF-4 mRNA. Although mouse embryos expressed FGF-4 mRNA from the 1-cell stage, embryos cultured from the 2-cell through the blastocyst stage in …

Bacteriuria And Pregnancy Outcome: A Prospective Hospital-Based Study In Pakistani Women, Rahat N. Qureshi, Khalid S. Khan, Omar Darr, Nasir Khattak, Bader J. Farooqui, Javed H. Rizvi

Department of Obstetrics & Gynaecology

The prevalence of bacteriuria in Pakistani women and its association with complications of pregnancy was studied. Out of 1579 women, 77 had bacteriuria (4.8%). There was no association of age, gravidity, parity, haemoglobin, pre-eclampsia, mode of delivery, gestational age at delivery, preterm delivery and low birth-weight with presence of bacteriuria. With detection and treatment the pregnancy outcome of women with bacteriuria in pregnancy was the same as that of those without.

Ai : Artificial Insemination Of Sheep, David Windsor

Journal of the Department of Agriculture, Western Australia, Series 4

Artificial insemination (Al) is used widely in the dairy and beef industries and often performed by farmers themselves. By contrast, sheep breeders generally require assistance from vets when frozen semen is to be used. However, recent experiments with frozen semen are indicating that do-it-yourself Al may soon become a reality.

Health Professions Division Catalog 1994-1995, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Penetration Of Piperacillin/Tazobactam Into Gynecologic Tissues Following A Single Loading Dose Prior To Hysterectomy, William F. O'Brien, Shelley George

Obstetrics & Gynecology Faculty Publications

Objective: This study was undertaken to determine plasma and pelvic tissue concentrations of piperacillin/tazobactam following a single intravenous administration.Methods: Plasma and tissue samples were obtained following administration of 3 g of piperacillin and 0.375 g of tazobactam. Concentrations of these agents were determined by chromatography.Results: Plasma concentrations (mean ±SD) for piperacillin/tazobactam were 208 ± 87/27 ± 8 and 95 ± 53/14 ± 2, respectively, at 30 and 60 min after the start of the infusion. The 8:1 ratio between piperacillin and tazobactam in plasma remained constant for up to 96 min. Tissue concentrations yielded a broader range, but …

Gatekeeping Access To Emergency Departments: A Survey Of Hmo Policies, Regina Conway Phillips

Master's Theses

No abstract provided.

Oncolog, Volume 39, Number 03, July-September 1994, Kimberly J. T. Herrick, Sunita Patterson

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Familial cancer syndromes a focus of cancer genetics research
• New test identifies Philadelphia chromosome-positive leukemias

Oncolog, Volume 39, Number 02, April-June 1994, Vickie J. Williams, Kathryn L. Hale

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Outwitting unknown primary tumors
• Synthetic peptide effectively controls the spread of HIV in human cell cultures
• Biological response modifiers promising adjuvants to cancer therapy

Oncolog, Volume 39, Number 01, January-March 1994, Sunita Patterson, Maureen E. Goode, Kathryn L. Hale

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Liposomal muramyl tripeptide kills bone cancer cells by stimulating the immune system Gene therapy at M. D. Anderson
• Researcher studies the hemopreventive power of garlic

Oncolog, Volume 39, Number 04, October-December 1994, Linda N. Eppich, Maureen E. Goode, Kathryn L. Hale

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Looking for solutions to ethical problems in the clinic
• Interferon: the evolution of a biological therapy
• Colon cancer registry coordinates treatment, education, and research

Digest Of The Philadelphia College Of Osteopathic Medicine (Winter 1994), Philadelphia College Of Osteopathic Medicine

Digest

The Winter 1994 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• President's Perspective: Our Commitment to Primary Care
• The Consummate Educator and Physician: Fairman Denlinger, DO, ‘53
• Richard S. Koch, DO, ‘38
• Connie McKenzie: Bookkeeping with a Personal Touch
• Cardiology Teaching Facility Opens
• AOA and ACOS Conventions: The Place to be for PCOM Alumni
• Alumni Profile: Kathryn Campanella, DO, '88
• Elders Addresses PCOM
• Class Acts
• Obituaries
• In Memoriam
• Coming Events

Social Security Reform: A Budget Neutral Approach To Reducing Older Women's Disproportional Risk Of Poverty, Richard V. Burkhauser, Timothy M. Smeeding

Center for Policy Research

Perhaps the single greatest achievement of social policy in the United States over the last three decades has been reducing poverty in old age. The transition from work to retirement is no longer economically perilous for the vast majority of older American workers. For most married couples, the risk of falling into poverty even several years after retirement is small. But when one partner of the marriage dies, the survivor faces another much more risky economic transition. The single greatest risk of falling into poverty in old age now comes after the death of a spouse, as the survivor faces …

Clients' Perceptions Of Preparedness For Discharge Home Following Total Hip Or Knee Replacement Surgery, Cindy H. Nicholson

Masters Theses

This study used a descriptive design to evaluate discharge planning by examining the clients' perception of preparedness for discharge home following total hip or knee replacement surgery. The conceptual framework was based upon the Betty Neuman Systems Model.; This study used Lawton's (1991) "Discharge Preparation Questionairre" to ascertain the clients' perceptions of preparedness in 10 discharge categories. Perceived preparation was measured using a 5 point summated rating scale. The study site was a 42-bed orthopedic unit in a 119 bed acute care hospital in Southeast Michigan. The convenience sample, of 46 adult clients, were interviewed by phone 3 days following …

The Chemistry Of Allergies, Henry Daley

Bridgewater Review

No abstract provided.

Integrative Theories Of Medicine: A (W)Holistic Vision, Kathryn B. Forestal

Master's Theses

No abstract provided.

Complexity Of Fetal Movement Detection Using A Single Doppler Ultrasound Transducer, William A. Russell Jr., Curtis L. Lowery, Patrick J. Baggot, James D. Wilson, Robert Walls, Roger M. Hawk, Pam Murphy

Journal of the Arkansas Academy of Science

The objective of this paper is to discuss the complexity of fetal movement detection encountered during development and implementation of an automated single Doppler ultrasonic transducer based instrument. The single transducer instrument was intended to better quantify the duration, velocity, and magnitude of fetal movements. A Corometrics Model 116 fetal heart rate monitor was modified, and a fetal movement detection algorithm (Russell Algorithm) was developed to detect fetal movements on one and two (data fusion) transducers. A Hewlett-Packard (HP) M-1350-A fetal monitor and the Russell Algorithm were used to detect and record fetal movements concurrently on sixty patients between the …

Bacteriuria And Pregnancy Outcome: A Prospective Hospital-Based Study In Pakistani Women, Rahat Qureshi, Khalid S. Khan, Omar Darr, Nasir Khattak, Javaid H. Rizvi, Bader J. Farooqui

Department of Obstetrics & Gynaecology

The prevalence of bacteriuria in Pakistani women and its association with complications of pregnancy was studied. Out of 1579 women, 77 had bacteriuria (4.8%). There was no association of age, gravidity, parity, haemoglobin, pre-eclampsia, mode of delivery, gestational age at delivery, preterm delivery and low birth-weight with presence of bacteriuria. With detection and treatment the pregnancy outcome of women with bacteriuria in pregnancy was the same as that of those without

The Prevalence Of Behavioural Risk Factors Associated With Sudden Infant Death Syndrome, Ann M. Callaghan

Theses : Honours

Sudden Infant Death syndrome (SIDS) is a major cause of death in the first year of life. In Western Australia (WA), two infants in every thousand live births die from SIDS each year. The aim of this study was to ascertain the prevalence in WA of three risk factors which have been associated with SIDS, namely prone lying, maternal smoking and lack of breast feeding. In addition the study sought to determine the significant influences that encourage change in infant care practices by parents. The study obtained information from child health nurses and midwives regarding the advice they provide on …

Basic Fibroblast Growth Factor And Fibroblast Growth Factor Receptor I Are Implicated In The Growth Of Human Astrocytomas., R S Morrison, F Yamaguchi, H Saya, J M Bruner, Alan M. Yahanda Md, Facs, L A Donehower, M Berger

PCI Publications and Projects

Malignant astrocytomas are highly invasive, vascular neoplasms that comprise the majority of nervous system tumors in humans. A strong association has previously been made between malignancy in human astrocytic tumors and increased expression of certain fibroblast growth factor (FGF) family members, including basic and acidic FGF. The influence of endogenous basic FGF on glioblastoma cell growth in vitro was evaluated using basic FGF-specific antisense oligonucleotides. These studies indicated that human glioblastoma cell growth in vitro, can be inhibited by suppressing basic FGF expression. Human astrocytomas also exhibited changes in FGF receptor (FGFR) expression during the course of their progression from …

Anaemia In Pregnancy - Its Cause In The Underprivileged Class Of Karachi, Saadiya Aziz Karim, Mohammad Khurshid, A.M. Memon, Sadiqua N. Jafarey

Section of Haematology/Oncology

A prospective study of the frequency and type of anaemia amongst poor urban parturients of Karachi was done. It was performed at 2 large teaching hospitals over the time span January to September, 1990. Out of 318 women studied, 104(32.7%) were anaemic (Hb levels <10gm/dl). The type of anaemia was assessed. Iron deficiency predominated and was seen amongst 63.5% of the anaemic population. There was an even distribution of other kinds of anaemia amongst the remainder of the population

Cardiovascular Risk Factors In School Children From Low Middle Income Families In Karachi, Pakistan, Salma H. Badruddin, A. Molla, Mohammad Khurshid, S. Vaz, S. Hassanali

Section of Haematology/Oncology

Serum levels of total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and trigly cerides (TG) were determined on 239 school children aged 5-19 years belonging to lower middle class families. The mean TC, LDL-C, HDL-C and TG ranged from 3.70-4.37 mmol/L, 2.17- 2.70 mmol/L, 0.94-1.14 mmol/L, 1.07-1.26 mmol/L respectively. In general, girls had higher TC, LDL-C and HDL-C levels. There was no significant difference in the TG levels between boys and girls. Thirty-three percent of the girls and 22% of the boys had TC level _4.4 mmol/L, the level at which dietary intervention is recommended …