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Simulated Science: Clinical Microbiology Lessons With Operation Outbreak, Melissa Poua

Open Educational Resources

This resource includes suggested teaching materials, posters and other visual aids, and two worksheets in epidemiology and virology, respectively. The target audience for this resource is healthcare majors in clinical microbiology courses. The laboratory activities are adapted to work with a free hands-on teaching phone application (Operation Outbreak) that models an outbreak in real-time, allowing the students to explore interventions and mitigation strategies.

Further details and instructions.

Replicating Single-Cycle Adenovirus Vectors Generate Amplified Influenza Vaccine Responses, Catherine M. Crosby, William E. Matchett, Stephanie S. Anguiano-Zarate, Christopher A. Parks, Eric A. Weaver, Larry R. Pease, Richard J. Webby, Michael A. Barry

Nebraska Center for Virology: Faculty Publications

Head-to-head comparisons of conventional influenza vaccines with adenovirus (Ad) gene-based vaccines demonstrated that these viral vectors can mediate more potent protection against influenza virus infection in animal models. In most cases, Ad vaccines are engineered to be replication-defective (RD-Ad) vectors. In contrast, replication-competent Ad (RC-Ad) vaccines are markedly more potent but risk causing adenovirus diseases in vaccine recipients and health care workers. To harness antigen gene replication but avoid production of infectious virions, we developed “single-cycle” adenovirus (SC-Ad) vectors. Previous work demonstrated that SC-Ads amplify transgene expression 100-fold and produce markedly stronger and more persistent immune responses than RD-Ad vectors …