Digital Commons Network^™

Instrumentation And Control For A Microprocessor-Based Coronary Perfusion System, Daniel L. Priester

Master's Theses (1922-2009) Access restricted to Marquette Campus

No abstract provided.

The Role Of Gaba In Reproductive Neuroendocrine Systems, Robert Carter Mcree

Theses and Dissertations in Biomedical Sciences

Local gamma-amino butyric acid (GABA) neurons in the hypothalamus can modulate the luteinizing hormone releasing hormone (LHRH) pulse generating system.

Two animal models (intact and ovariectomized rats) were used to determine the nature of modulation of LHRH release by GABA. The experiment determined the release of LHRH, serotonin (5-HT), and 5-hydroxyindole acetic acid (5-HIAA) during two hormonal states with each model. In the intact rat the proestrus and estrus states were examined, and in the ovariectomized rat in-vitro release was determined with (OVX₂) and without (OVX) estradiol treatment.

In-vivo experiments studied the effect of stimulation of GABA receptors …

Transplantation Of The Mammalian Pineal Gland: Studies Of Survival, Revascularization, Reinnervation And Recovery Of Function, Wutian Wu

Theses and Dissertations in Biomedical Sciences

The survival, revascularization, reinnervation, and recovery of function of transplanted newborn rat pineal glands were studied following grafting into four different locations in pinealectomized rats. These locations were the third cerebral ventricle, in situ (where the pineal gland is normally located), the renal capsule, and the anterior chamber of the eye.

Pinealocytes in the grafts maintained high metabolic activity as evidenced by the presence of euchromatic nuclei, prominent nucleoli, infolded nuclear envelopes, numerous mitochondria and Golgi apparati, and relatively abundant endoplasmic reticulum and ribosomes. In addition, morphological correlates of two putative secretory processes were observed in the grafts. The first …

Beta-Adrenergic Blocking Agents In The Treatment Of Patients After A Myocardial Infarction, Sidney Goldstein

Henry Ford Hospital Medical Journal

Beta-adrenergic blocking agents have been widely used in ischemic heart disease. They have achieved their greatest benefit in the secondary prevention of recurrent events in patients following acute myocardial infarction (Ml). This is a review of the major clinical investigations exploring the effects of beta-adrenergic blocking agents in patients following acute Ml and in a variety of patient subsets. These data indicate that the routine use of beta-adrenergic blocking agents in postinfarction patients results in a 25% to 35% decrease in mortality and has increased relative and absolute benefit in patients with ventricular ectopy and left ventricular dysfunction. The adverse …

Prehospital Care Of Acute Myocardial Infarction: A Review, Asit R. Gokli, Jay L. Kovar, Terry Kowalenko, Richard M. Nowak

Henry Ford Hospital Medical Journal

Each year more than 1 million people in the United States suffer from acute myocardial infarction (Ml) with most of the deaths occurring within hours of symptom onset. Over the last 25 years, different prehospital systems have evolved throughout the world which allow early cardiac monitoring and treatment of acute Ml patients. Thrombolytic therapy in acute Ml has been shown to decrease mortality and preserve left ventricular function when administered early after onset of symptoms. The potential role of Emergency Medical Services or Mobile Coronary Care Units in achieving early thrombolysis is under investigation. Several studies of prehospital interventions to …

Recent Concepts In Clinical Psychiatry: Drug Treatment In Schizophrenia, Shahin H. Hussain

Department of Psychiatry

No abstract provided.

Neuroendocrine Responses To Acute Myocardial Infarction, Arlene B. Levine, T. Barry Levine

Henry Ford Hospital Medical Journal

No abstract provided.

Recovery Of Left Ventricular Function Following Acute Myocardial Infarction, Hani N. Sabbah, Paul D. Stein, Mihai Gheorghiade

Henry Ford Hospital Medical Journal

No abstract provided.

Thrombolytic Therapy In Acute Myocardial Infarction: An Emergency Department Perspective, Bradford L. Walters

Henry Ford Hospital Medical Journal

No abstract provided.

Diagnosis And Management Of Tachycardias After Myocardial Infarction, Charles R. Webb

Henry Ford Hospital Medical Journal

No abstract provided.

Expression Of A Human Cartilage Procollagen Gene (Col2a1) In Mouse 3t3 Cells., Leena Ala-Kokko, James Hyland, Carol Smith, Kari I. Kivirikko, Sergio A. Jimenez, Darwin J. Prockop

Department of Medicine Faculty Papers

Expression in a recombinant system has been difficult to obtain for any of the major fibrillar collagens that require processing by eight or more post-translational enzymes. Here, two DNA constructs were designed so that the promoter region of the gene for the pro-alpha 1(I) chain of human type I procollagen drove expression of the human type II procollagen gene in mouse NIH 3T3 cells, a culture line that normally synthesizes type I procollagen but not any cartilage-specific protein such as type II procollagen. Both constructs were expressed as both mRNA and protein. In clones expressing the construct at high levels, …

Oncolog, Volume 36, Issue 03, July-September 1991, Emil J. Freireich Md, James M. Bowen Phd

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• From cell culture to clinical protocol: In cancer research, the goals of scientist and clinician converge New clinic treats depressed cancer patients
• Half-century of progress in leukemia research

New Purine Analogues For The Treatment Of Chronic B-Cell Malignancies, Thomas E. Gribbin

Henry Ford Hospital Medical Journal

Adenosine deaminase (ADA). a purine salvage pathway enzyme, appears to play a key role in normal lymphocyte growth, development, and differentiation. Three new purine nucleoside analogues, deoxycoformycin, fludarahine, and 2-chlorodeoxyadenosine, affect the normal function of the purine salvage pathway by inhibiting ADA or by acting as analogs of the ADA substrates. These agents show significant activity in the treatment of chronic B-cell leukemias and low-grade lymphomas. The pharmacology, mechanism of action, and clinical usefulness of these agents are discussed.

Peripheral Blood Stem Cell Transplantation As An Alternative To Bone Marrow Transplantation: An Overview, Nalini Janakiraman

Henry Ford Hospital Medical Journal

Stem cells capable of restoring hematopoiesis following lethal bone marrow injury circulate in the blood of many animals, including humans. When collected through leukapheresis and reinfused following high-dose chemotherapy, stem cells offer a treatment option not currently open to some patients who are unable to undergo autologous bone marrow transplantation because of tumor involvement in the pelvis, prior pelvic radiation, or intolerance to general anesthesia. After stem cell infusion, hematologic and immunologic recovery are rapid in comparison to that after autologous hone marrow reinfusion: however, in some cases platelet engraftment is slower. There is some evidence that tumor contamination in …

Development And Characterization Of Monoclonal Antisperm Antibodies: Potential For Contraception, Dilrowshan H. Haque

Theses and Dissertations in Biomedical Sciences

There is an expressed need to develop a greater variety of safe contraceptive methods which would find acceptance worldwide, particularly in developing countries. Immunization against spermatozoa might be such a method as judged by the accumulated evidence from studies on human females and in a number of female animal species.

Two extraction techniques were used for sperm membrane antigen isolation. The first technique involved NP-40 detergent for antigen extraction from human motile sperm and the second technique employed homogenized human testis for antigen extraction. Using these immunogens, sperm membrane-specific monoclonal antibodies (MAbs) were developed. When these antisperm MAbs were subjected …

Nutrition Support Of Hiv+ Patients, Johanna T. Dwyer

Henry Ford Hospital Medical Journal

Case management strategies for the nutritional support of patients infected with the human immunodeficiency virus (HIV) are evolving as the disease becomes less rapidly fatal and more chronic. Nutritional status changes in advanced HIV infection are similar in many respects to protein-calorie malnutrition. Current clinical effort and research focuses on the beneficial effects of preserving lean body mass and keeping asymptomatic patients in good nutritional status by preventing micronutrient deficiencies and by treating preexisting nutritional problems rather than attempting to intervene late in the disease's course, after secondary malnutrition has already developed. Nutrition support and intervention trials only late in …

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Disturbances In Lipid Metabolism Associated With Chylothorax And Its Management, Malachi J. Mckenna, Jau-Wen Chu, Dorothy M. Kahkonen

Henry Ford Hospital Medical Journal

Changes in circulating lipid status were studied in a 70-year-old woman during management of chylothorax that included chest drainage, pleuroperitoneal shunting, and a successful thoracic duct ligation. Hypolipidemia with a relative decline in high-density lipoprotein (HDL) cholesterol was apparent at presentation. Following recovery, serum HDL cholesterol rose to the upper limit of normal. Apolipoprotein A-l (Apo A-l) was discordantly raised during the period of pleuroperitoneal shunting. We speculate that diversion of chylomicrons to the liver with subsequent hydrolysis accounted for a release of Apo A-l particles into the circulation at a time when the formation of HDL was compromised by …

Molecular Mechanism Of The Stimulation Of Alkaline Phosphatase Activity In Human Bone Cells By 1,25(Oh)2 D3, Eru Kyeyune-Nyombi

Loma Linda University Electronic Theses, Dissertations & Projects

To facilitate this study an in vitro human model system was established that exhibited many aspects of normal osteoblasts. The human osteosarcoma cell line (TE85 cells) expressed a skeletal alkaline phosphatase activity (an accepted bone cell differentiation marker) which was stimulated by 1,25(OH)₂D₃ (a potent differentiating agent), under serum-free conditions in a dose-dependent, time-dependent, and cell density-dependent manner. Cytochemical analysis of the stimulation of ALP activity by 1,25(OH)₂D₃ showed that 1,25(OH)₂D₃ increased the number of TE85 cells that expressed detectable ALP activity, suggesting that 1,25(OH)₂D₃ promoted the process …

Oncolog, Volume 36, Issue 02, April-June 1991, Gilbert H. Fletcher M.D., James M. Bowen Phd

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Redefining the risks of chemotherapy during pregnancy Renewing the assault on pancreatic cancer
• Significance of cancer volume in radiotherapy

Oncolog, Volume 36, Issue 01, January-March 1991, Michael S. Ewer Md, Mph, T. C. Hsu Ph.D., John R. Redman M.D.

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Decision making in critical illness: Who knows best?
• Successful Hodgkin's disease treatment can also preserve reproductive function
• Chromosomes and cancer

Digest Of The Philadelphia College Of Osteopathic Medicine (Winter 1991), Philadelphia College Of Osteopathic Medicine

Digest

The Winter 1991 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• A Master Plan to Grow on: City Avenue Campus
• Emanuel Fliegelman, DO: Reminding Us That to be Human is to be Best
• PCOM's Computer Hospital: High-tech Medical Education
• New Appointments
• On Campus
• Just Published
• Class Acts
• In Memoriam
• Coming Events

The Physiologic Basis For Nutritional Support In Hepatic Failure, John J. Fath

Henry Ford Hospital Medical Journal

Hepatic failure is often perceived as a unidimensional progression from near normal clinical function (Child's class A) to overt clinical failure (Child's class C). As this view fails to distinguish between patients who are capable of using exogenous protein and those who cannot, it hinders the nutritional support team in determining protein supplementation. This report addresses the physiologic basis for variable findings in hepatic failure and proposes a simple definition of hepatic faliure based upon ability to utilize amino acids.

Vital Signs, December 1990, Boonshoft School Of Medicine

Vital Signs

A fifteen page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

Digest Of The Philadelphia College Of Osteopathic Medicine (Fall 1990), Philadelphia College Of Osteopathic Medicine

Digest

The Fall 1990 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• President’s Perspective
• In the News
• Up, Up and Away
• "This Joyous Gathering of Our Family"
• The College Chancellor, Reminiscing
• New Appointments
• On Campus
• Class Acts
• In Memorium
• Coming Up

The Effect Of Oxygen On Corneal Neovascularization, M. A. Culton, D. B. Chandler, A. D. Proia, D. W. Hickingbotham, G. K. Klintworth

Osteopathic Medicine, Jerry M. Wallace School of

Since tissue oxygen levels are believed to play a pivotal role in new vessel growth in several situations, we studied the effect of several oxygen concentrations (0, 10, 21, 50, 75, or 100%) on corneal vascularization induced in the rat by chemical cautery. We achieved this by perfusing known concentrations of oxygen through goggles fitted over both eyes of the rat after corneal cauterization. Neovascularization was measured in flat corneal preparations with India ink-filled vessels 4 days postcautery using computerized image analysis. The angiogenic response of rats whose eyes were continuously exposed to 0-75% oxygen were not significantly different from …

Morphological And Physiological Examination Of A Demyelinating And Remyelinating Lesion, Paul Anson Felts

Theses and Dissertations in Biomedical Sciences

Multiple sclerosis causes demyelination of central nerve fibers, and it is this pathology which results in most of the symptoms of the disease. The repair of the fibers by remyelination has been advanced as a potential symptomatic therapy, but at present the conduction properties of remyelinated central fibers are not well understood. In this study the conduction properties of Schwannian or oligodendrocyte remyelinated central nerve fibers have been determined. In addition, the status of the blood-brain barrier has been examined in lesions characterized by Schwann cell remyelination. These lesions chronically lack astrocytes, a cell believed to be involved in the …

C. Paul Hodgkinson, Md, Dorothy Porter

Henry Ford Hospital Medical Journal

No abstract provided.

Cocaine-Induced Hepatonephrotoxicity: A Case Report, Guillermo P. Gubbins, Rhett M. Schiffman, Ravindra S. Alapati, Surinder K. Batra

Henry Ford Hospital Medical Journal

Hepatotoxicity due to cocaine has been well described in animal models. There are few reports on cocaine-induced hepatic injury in humans; however, its link to rhabdomyolysis and renal failure is better known. We report a case of reversible acute hepatonephrotoxicity associated with recreational cocaine use. The proposed mechanisms responsible for its hepatic and renal toxicity are reviewed.