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Reliability And Validity Of The Turkish Version Of The Nose-Perf Scale ​, Aykut Özdoğan, Zülküf Küçüktağ, Gökçe Saygi Uysal, Enes Ahmet Subay, Serdar Özer Oct 2026

Reliability And Validity Of The Turkish Version Of The Nose-Perf Scale ​, Aykut Özdoğan, Zülküf Küçüktağ, Gökçe Saygi Uysal, Enes Ahmet Subay, Serdar Özer

Turkish Journal of Medical Sciences

Background/aim: The objective of this study was to evaluate the validity and reliability of the Turkish version of the NOSE-Perf scale, developed to assess symptom severity and quality of life in patients with nasal septal perforation (NSP), and to compare the symptom profile of patients with NSP with those of the nasal obstruction and healthy control groups.

Materials and methods: To evaluate the temporal stability of the NOSE-Perf scale, a test–retest assessment was performed in the NSP group at a 1-month interval. Internal consistency was assessed using Cronbach’s alpha coefficient, while discriminative validity was evaluated using receiver operating characteristic (ROC) …


Methylphenidate-Related Cardiac And Cardiovascular Safety: A Bibliometric And Network Analysis ​, Ömer Çağlar Yilmaz, Sadetti̇n Burak Açikel Oct 2026

Methylphenidate-Related Cardiac And Cardiovascular Safety: A Bibliometric And Network Analysis ​, Ömer Çağlar Yilmaz, Sadetti̇n Burak Açikel

Turkish Journal of Medical Sciences

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Background/aim: Methylphenidate is widely used for the treatment of attention-deficit/hyperactivity disorder (ADHD); however, concerns regarding its cardiac and cardiovascular safety remain clinically relevant. This study aimed to delineate the scientific landscape of methylphenidate-related cardiac and cardiovascular safety using bibliometric methods.

Materials and methods: The Science Citation Index Expanded, Social Sciences Citation Index, and Emerging Sources Citation Index were used to search the Web of Science Core Collection. A proximity-based search that combined terms related to methylphenidate, cardiovascular health, and safety/adverse events retrieved 263 records. There were 244 publications in the dataset after only including articles and reviews. VOSviewer was …


Reporting Consistency And Functional Interpretation In Comprehensive Geriatric Assessment Of Older Adults With Heart Failure ​, Ahmet Aykut Oct 2026

Reporting Consistency And Functional Interpretation In Comprehensive Geriatric Assessment Of Older Adults With Heart Failure ​, Ahmet Aykut

Turkish Journal of Medical Sciences

No abstract provided.


Intrafamilial Variability In Autosomal Dominant Polycystic Kidney Disease Due To A Shared Pkd1 Mutation: A Potential Signal Of Sodium-Glucose Cotransporter-2 (Sglt2) Inhibitor Benefit ​, Sai̇de Eli̇f Güllülü Boz, Hande Aypek, Gökhan Öngen, Gülşah Çeçener, Alparslan Ersoy, Abdulmeci̇t Yildiz Oct 2026

Intrafamilial Variability In Autosomal Dominant Polycystic Kidney Disease Due To A Shared Pkd1 Mutation: A Potential Signal Of Sodium-Glucose Cotransporter-2 (Sglt2) Inhibitor Benefit ​, Sai̇de Eli̇f Güllülü Boz, Hande Aypek, Gökhan Öngen, Gülşah Çeçener, Alparslan Ersoy, Abdulmeci̇t Yildiz

Turkish Journal of Medical Sciences

No abstract provided.


Quality Of Life And Religiosity Of Breast Cancer Patients Undergoing Adjuvant Ultra-Hypofractionated Radiotherapy With Sequential Tumor Bed Boost: A Pilot Study, Efrosyni Kypraiou, Ioannis Koukourakis, Andromachi Kougioumtzopoulou, Kalliopi Platoni, Marina Chalkia, Kyveli Zourari, Efstathios Efstathopoulos, Nikolaos Kelekis, Anna Zygogianni, Vassilis Kouloulias Oct 2026

Quality Of Life And Religiosity Of Breast Cancer Patients Undergoing Adjuvant Ultra-Hypofractionated Radiotherapy With Sequential Tumor Bed Boost: A Pilot Study, Efrosyni Kypraiou, Ioannis Koukourakis, Andromachi Kougioumtzopoulou, Kalliopi Platoni, Marina Chalkia, Kyveli Zourari, Efstathios Efstathopoulos, Nikolaos Kelekis, Anna Zygogianni, Vassilis Kouloulias

Turkish Journal of Medical Sciences

Background/aim: Quality of life (QoL) is an important parameter that should be taken into account when assessing treatment efficacy in cancer patients. The FAST-FORWARD radiotherapy (RT) regimen (5-day schedule) for early-stage breast cancer has been reported by both physicians and patients to be associated with toxicity comparable to that of longer schedules. However, the impact of the addition of a tumor bed boost to ultrahypofractionated RT on patient QoL has not been extensively reported to date.

Materials and methods: QoL was assessed before and after RT and again 3 months later in 24 patients with early-stage breast cancer who underwent …


Factors Associated With Relapse In Anca-Associated Vasculitis: A Single-Center Retrospective Cohort Study ​, Serdar Sezer, Şeyda Yi̇ği̇tbaşi, Zehra Karaman Ongun, Emi̇ne Uslu, Müçteba Enes Yayla, Aşkin Ateş, Tahsi̇n Murat Turgay Oct 2026

Factors Associated With Relapse In Anca-Associated Vasculitis: A Single-Center Retrospective Cohort Study ​, Serdar Sezer, Şeyda Yi̇ği̇tbaşi, Zehra Karaman Ongun, Emi̇ne Uslu, Müçteba Enes Yayla, Aşkin Ateş, Tahsi̇n Murat Turgay

Turkish Journal of Medical Sciences

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Background/aim: Relapse remains common in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). We examined factors associated with relapse after remission.

Materials and methods: We retrospectively reviewed 130 adults with AAV followed between January 2015 and May 2026, all of whom achieved remission after induction therapy. Demographics, disease subtype, serology, organ involvement, baseline laboratory values, treatments, and relapse were recorded. Relapse was defined as recurrent vasculitic activity after remission requiring escalation/ modification of immunosuppressive therapy. Time from remission to first relapse was analyzed using Cox proportional hazards regression, with serious infection modeled as a time-dependent covariate. No imputation was undertaken.

Results: …


Collateral Circulation As A Predictor Of Reperfusion Injury: Insights From Mechanical Thrombectomy In Stroke Patients ​, Eli̇f Uzun Ata, Asi̇ye Sözeri̇, Gürdal Orhan Oct 2026

Collateral Circulation As A Predictor Of Reperfusion Injury: Insights From Mechanical Thrombectomy In Stroke Patients ​, Eli̇f Uzun Ata, Asi̇ye Sözeri̇, Gürdal Orhan

Turkish Journal of Medical Sciences

Background/aim: The purpose of this study was to evaluate the association between collateral circulation (CC) status on preprocedural brain CT angiography (BCTA) and the development of postthrombectomy hemorrhagic transformation (HeT) and contrast extravasation (CE) in patients with acute ischemic stroke.

Materials and methods: This retrospective, single-center study included 185 patients with middle cerebral artery occlusion who underwent mechanical thrombectomy (MT) between February 2019 and October 2022 and achieved complete angiographic reperfusion with a final Thrombolysis in Cerebral Infarction grade of 3. Preprocedural CC was assessed on biphasic BCTA using a modified threecategory grading approach and classified as good, moderate, or …


Clinical And Prognostic Significance Of Glomerulonephritis In Clinically Indicated Kidney Allograft Biopsies ​, Hati̇ce Şahi̇n, Fatma Ayerden Ebi̇nç, Gülay Ulusal Okyay, Emre Yaşar, Ebru Gök Oğuz, Fevzi̇ Coşkun Sökmen, Kadi̇r Gökhan Atilgan, Ebru Şebnem Ayva, Mehmet Deni̇z Ayli Oct 2026

Clinical And Prognostic Significance Of Glomerulonephritis In Clinically Indicated Kidney Allograft Biopsies ​, Hati̇ce Şahi̇n, Fatma Ayerden Ebi̇nç, Gülay Ulusal Okyay, Emre Yaşar, Ebru Gök Oğuz, Fevzi̇ Coşkun Sökmen, Kadi̇r Gökhan Atilgan, Ebru Şebnem Ayva, Mehmet Deni̇z Ayli

Turkish Journal of Medical Sciences

Background/aim: Posttransplant glomerulonephritis (GN) is an underrecognized but clinically important cause of allograft dysfunction. It remains uncertain whether GN detected in a clinically indicated kidney allograft biopsy provides prognostic information beyond graft function and chronic histological injury. The present study evaluates the association between biopsy-detected GN and death-censored graft loss.

Materials and methods: Included in this retrospective single-center study were kidney transplant recipients (KTRs) who underwent clinically indicated allograft biopsy between May 2012 and October 2025. The primary outcome was death-censored graft loss, defined as a return to kidney replacement therapy. Postbiopsy graft survival was assessed using Kaplan–Meier analysis and …


Turkish Translation, Cultural Adaptation, And Validation Of The Patient-Reported Villalta Scale For The Diagnosis Of Postthrombotic Syndrome In Patients With Vascular Behçet Disease ​, Tuğçe Kübra Güneş, Murat Karabacak, Mehmet Umut Çapar, Tüli̇n Ergun, Rafi̇ Haner Di̇reskeneli̇, Fatma Ali̇baz Öner Oct 2026

Turkish Translation, Cultural Adaptation, And Validation Of The Patient-Reported Villalta Scale For The Diagnosis Of Postthrombotic Syndrome In Patients With Vascular Behçet Disease ​, Tuğçe Kübra Güneş, Murat Karabacak, Mehmet Umut Çapar, Tüli̇n Ergun, Rafi̇ Haner Di̇reskeneli̇, Fatma Ali̇baz Öner

Turkish Journal of Medical Sciences

Background/aim: Lower extremity deep vein thrombosis (DVT) constitutes 70% of all vascular findings related to Behçet disease (BD). Postthrombotic syndrome (PTS) is a serious complication of DVT that develops due to chronic venous insufficiency and decreases the patient’s quality of life. The physician-reported Villalta scale is a widely used and validated diagnostic tool for diagnosing and evaluating the severity of PTS. However, the necessity of physical examination by a physician burdens the clinician during routine practice. For that reason, a patient-reported Villalta scale was developed and validated. This study aimed to translate the patient-reported Villalta scale into Turkish and validate …


Epicardial Adipose Tissue Thickness And Aortic Elasticity In Seronegative And Seropositive Rheumatoid Arthritis: A Comparative Evaluation Of Subclinical Cardiometabolic Burden ​, Abdullah Nabi̇ Aslan, Yunus Emre Özbebek Oct 2026

Epicardial Adipose Tissue Thickness And Aortic Elasticity In Seronegative And Seropositive Rheumatoid Arthritis: A Comparative Evaluation Of Subclinical Cardiometabolic Burden ​, Abdullah Nabi̇ Aslan, Yunus Emre Özbebek

Turkish Journal of Medical Sciences

Background/aim: Rheumatoid arthritis (RA) is a systemic inflammatory disease associated with both joint pathology and elevated cardiovascular disease risk. Epicardial adipose tissue thickness (EATT) and aortic elasticity parameters are emerging cardiometabolic markers associated with systemic inflammation and subclinical atherosclerosis. Although the relationship between EATT, aortic elasticity parameters, and RA has been increasingly documented, differences in these parameters between seronegative rheumatoid arthritis and seropositive rheumatoid arthritis remain underexplored.

Materials and methods: Of the 396 consecutive patients with RA, only those free of established cardiovascular disease and uncontrolled cardiovascular risk factors were included. As a result, 80 patients with RA and 43 …


Impact Of Weather Changes On Pediatric Trauma: A Detailed Demographic Analysis ​, Nuri̇ Koray Ülgen, Ali̇ Sai̇d Nazligül, Ni̇hat Yi̇ği̇t, Sadik Emre Ergi̇noğlu, Arslan Kağan Arslan, Mehmet Orçun Akkurt Oct 2026

Impact Of Weather Changes On Pediatric Trauma: A Detailed Demographic Analysis ​, Nuri̇ Koray Ülgen, Ali̇ Sai̇d Nazligül, Ni̇hat Yi̇ği̇t, Sadik Emre Ergi̇noğlu, Arslan Kağan Arslan, Mehmet Orçun Akkurt

Turkish Journal of Medical Sciences

Background/aim: Pediatric trauma creates substantial emergency and orthopedic workload, and fluctuations in volume may affect staffing and resources. This study investigated the associations of ambient temperature, precipitation, and calendar characteristics with pediatric orthopedic trauma consultations and fracture events, including age-, sex-, and fracture-location-specific patterns.

Materials and methods: All pediatric trauma-related consultations were requested from the Department of Orthopedics and Traumatology by the emergency department between June 1, 2023, and June 1, 2024, were retrospectively analyzed. Consultation and fracture data were aggregated daily. Negative binomial regression was used for count outcomes, temperature nonlinearity was tested using a quadratic term, and weighted …


Decoding The Silent Damage: Clinical And Electrophysiological Features Associated With Occupational N-Hexane Exposure ​, Mehli̇ka Panpalli Ateş, Umur Poyraz, Mustafa Yurtdaş, Emi̇n Gemci̇oğlu Oct 2026

Decoding The Silent Damage: Clinical And Electrophysiological Features Associated With Occupational N-Hexane Exposure ​, Mehli̇ka Panpalli Ateş, Umur Poyraz, Mustafa Yurtdaş, Emi̇n Gemci̇oğlu

Turkish Journal of Medical Sciences

Background/aim: This study aimed to investigate early findings in patients exposed to n-hexane while working in a shoe factory.

Materials and methods: Twenty-four patients exposed to n-hexane were evaluated by physical examination and electroneuromyography 2–5 weeks after the onset of paresthesia symptoms. The examination and electrophysiological results of these patients were assessed by different physicians who were blinded to both examinations.

Results: Among patients who had weakness, it was particularly obvious in the proximal muscles of the lower extremities. Nerve conduction studies showed decreased motor nerve conduction velocity, conduction block, prolonged distal latency, and prolonged F-wave latency in 20 patients. …


Patterns And Clinical Outcomes Of Necrotizing Soft Tissue Infections: A 5-Year Single-Center Cohort Study ​, Mert Can Rador, Ahmet Can Tuzluklu, Gaye Fi̇li̇nte, Kaan Gi̇deroğlu, Alperen Kahraman, Bi̇lal Eryildirim, Hasan Fehmi̇ Küçük Oct 2026

Patterns And Clinical Outcomes Of Necrotizing Soft Tissue Infections: A 5-Year Single-Center Cohort Study ​, Mert Can Rador, Ahmet Can Tuzluklu, Gaye Fi̇li̇nte, Kaan Gi̇deroğlu, Alperen Kahraman, Bi̇lal Eryildirim, Hasan Fehmi̇ Küçük

Turkish Journal of Medical Sciences

Background/aim: Necrotizing soft tissue infections are uncommon but rapidly lethal, and their perineal form, Fournier’s gangrene, is most often referred for reconstruction. Whether routine admission findings identify the highest-risk patients more accurately than severity scores remains uncertain, and whether sodium-glucose cotransporter-2 (SGLT-2) inhibitors, which are widely used in patients with diabetes, influence clinical outcomes also remains unclear.

Materials and methods: We retrospectively studied consecutive adults with necrotizing soft tissue infection at a tertiary referral center over 5 years. A subcohort of 70 patients who underwent plastic and reconstructive surgery was identified within the full institutional cohort of 137. Admission findings …


Endovascular Management Of Vascular Complications In Hemodialysis Patients: A Single-Center Experience ​, Ati̇ye Cenay Karabörk Kiliç, Burak Mert Akhan, Nemat Ibrahi̇mkhanli, Esra Kulaksiz Turan, Fati̇h Öncü, Mehmet Koray Akkan, Ahmet Baran Onal, Erhan Turgut Ilgit Oct 2026

Endovascular Management Of Vascular Complications In Hemodialysis Patients: A Single-Center Experience ​, Ati̇ye Cenay Karabörk Kiliç, Burak Mert Akhan, Nemat Ibrahi̇mkhanli, Esra Kulaksiz Turan, Fati̇h Öncü, Mehmet Koray Akkan, Ahmet Baran Onal, Erhan Turgut Ilgit

Turkish Journal of Medical Sciences

Background/aim: Vascular access failure remains a major cause of morbidity in patients undergoing hemodialysis. This study aimed to evaluate the types of endovascular interventions performed for hemodialysis-related vascular complications, as well as their technical success and patency outcomes, at a single center.

Materials and methods: A total of 103 lesions in 89 patients treated between 2001 and 2023 were retrospectively analyzed. Catheterrelated complications, central venous stenosis or occlusion, and arteriovenous fistula- or graft-related complications were managed using endovascular techniques. Endovascular interventions included catheter repositioning, thrombolysis, percutaneous transluminal angioplasty (PTA), stent placement for central venous lesions, PTA of the fistula vein …


Subclinical Trigeminal Involvement In Bell’S Palsy: Insights From Cranial Somatosensory Evoked Potentials ​, Ahmet Hakan Ekmekci̇, Burcu Sümeyye Çağar, Nadi̇re Ünver Doğan Oct 2026

Subclinical Trigeminal Involvement In Bell’S Palsy: Insights From Cranial Somatosensory Evoked Potentials ​, Ahmet Hakan Ekmekci̇, Burcu Sümeyye Çağar, Nadi̇re Ünver Doğan

Turkish Journal of Medical Sciences

Background/aim: Bell’s palsy (BP) has traditionally been considered an isolated peripheral facial nerve mononeuropathy; however, subclinical trigeminal involvement has been suggested. We evaluated whether cranial somatosensory evoked potentials (cSEP) demonstrate electrophysiological alterations in the trigeminal system in patients with BP.

Materials and methods: The records of 32 patients with BP who underwent cSEP between March 2010 and April 2023 were retrospectively reviewed. For the six patients without explicit chart documentation, the affected side was determined using acute-phase facial electromyography records. During routine clinical assessment, cSEP recordings were obtained using inferior alveolar nerve stimulation according to a standardized protocol. Latencies (N1, …


Association Between Acetabular Morphology Parameters And Hip Osteoarthritis: A Multivariable And Diagnostic Performance Analysis ​, Ni̇hat Yi̇ği̇t, Nuri̇ Koray Ulgen, Hayretti̇n Unal, Ali̇ Sai̇d Nazligul, Mehmet Orçun Akkurt, Arslan Kağan Arslan Oct 2026

Association Between Acetabular Morphology Parameters And Hip Osteoarthritis: A Multivariable And Diagnostic Performance Analysis ​, Ni̇hat Yi̇ği̇t, Nuri̇ Koray Ulgen, Hayretti̇n Unal, Ali̇ Sai̇d Nazligul, Mehmet Orçun Akkurt, Arslan Kağan Arslan

Turkish Journal of Medical Sciences

Background/aim: Acetabular morphology plays a fundamental role in hip biomechanics by influencing load distribution and maintaining cartilage integrity. Although the Sharp angle, lateral center–edge angle (LCEA), Tönnis angle, and acetabular depth are commonly used radiographic parameters, their independent associations with hip osteoarthritis (OA) and their relative diagnostic performance remain uncertain. This study evaluated these associations and compared their diagnostic utility.

Materials and methods: This retrospective study included standardized anteroposterior pelvis radiographs obtained between January 2021 and December 2024. Hips were classified according to the Kellgren–Lawrence (KL) grading system, with grade 0 hips assigned to the control group and grade ≥2 …


Microbiota Awareness And Glycaemic Status In Primary Care Patients: A Cross-Sectional Observational Study ​, Cansu Sepetçi̇, Erhan Şi̇mşek Oct 2026

Microbiota Awareness And Glycaemic Status In Primary Care Patients: A Cross-Sectional Observational Study ​, Cansu Sepetçi̇, Erhan Şi̇mşek

Turkish Journal of Medical Sciences

Background/aim: The aim in this study was to assess microbiota awareness in adults across different glycaemic groups and to investigate the association between microbiota awareness and HbA1c levels in a primary care population.

Materials and methods: This cross-sectional observational study included 330 adults aged 18–65 years: 110 participants with type 2 diabetes, 110 with prediabetes, and 110 without diabetes or prediabetes. Microbiota awareness was assessed using the Microbiota Awareness Scale (MAS), which was administered through face-to-face interviews. HbA1c values and relevant clinical data were obtained from medical records. Group differences in MAS scores were evaluated using both unadjusted analyses and …


Effects Of A Virtual Reality-Based Nature Video Intervention On Sleep Quality And Mental Well-Being In Patients With Multiple Sclerosis: A Randomized Controlled Trial ​, Hati̇ce Yağci Karamanli, Nuray Bi̇ngöl Oct 2026

Effects Of A Virtual Reality-Based Nature Video Intervention On Sleep Quality And Mental Well-Being In Patients With Multiple Sclerosis: A Randomized Controlled Trial ​, Hati̇ce Yağci Karamanli, Nuray Bi̇ngöl

Turkish Journal of Medical Sciences

Background/aim: Sleep quality and mental health are negatively affected in many patients with multiple sclerosis (MS). The study was conducted to evaluate the effects of virtual reality (VR) on sleep quality and mental well-being.

Materials and methods: The study was designed as a randomized controlled trial. Data were collected from patients with MS who presented to a hospital in Türkiye. The study was completed by 21 participants in the experimental group and 22 participants in the control group. Participants in the experimental group watched nature videos using VR headsets for 6 weeks. Participants completed the Pittsburgh Sleep Quality Index (PSQI) …


Posture And Musculoskeletal Symptom Burden, But Not Daily Step Count, Are Independently Associated With Physical Quality Of Life In Office Workers: A Cross-Sectional Study ​, Gülsemi̇n Ertürk Çeli̇k, Abdurrahman İskender, Ahmet Usta, Alper Doğanci Oct 2026

Posture And Musculoskeletal Symptom Burden, But Not Daily Step Count, Are Independently Associated With Physical Quality Of Life In Office Workers: A Cross-Sectional Study ​, Gülsemi̇n Ertürk Çeli̇k, Abdurrahman İskender, Ahmet Usta, Alper Doğanci

Turkish Journal of Medical Sciences

Background/aim: Office work is characterized by prolonged sitting and may be accompanied by musculoskeletal symptoms and reduced well-being. This study examined associations of step-based and self-reported physical activity, clinical posture, attitudes toward sports, smartphone addiction, and musculoskeletal symptom burden in office workers with the four domains of the World Health Organization Quality of Life Scale-Brief Version (WHOQOL-BREF).

Materials and methods: This cross-sectional analysis included 44 desk-based office workers at a public institution. WHOQOL-BREF domain scores were transformed to a 0–100 scale. Physical activity was assessed via 7-day average daily step counts and the International Physical Activity Questionnaire-Short Form (IPAQ-SF); posture …


Effects Of Topical And Systemic Pirfenidone On Postlaminectomy Epidural Fibrosis In A Rat Model ​, Özgür Öcal, Zuhal Yildirim, Ayşe Çakir Gündoğdu, Abdurrahi̇m Taş, Betül Yaman, Abdurrahman Çeti̇n, Gökhan Gürkan, Abdurrahman Aycan Oct 2026

Effects Of Topical And Systemic Pirfenidone On Postlaminectomy Epidural Fibrosis In A Rat Model ​, Özgür Öcal, Zuhal Yildirim, Ayşe Çakir Gündoğdu, Abdurrahi̇m Taş, Betül Yaman, Abdurrahman Çeti̇n, Gökhan Gürkan, Abdurrahman Aycan

Turkish Journal of Medical Sciences

Background/aim: To investigate the effect of topical and systemic administration of pirfenidone (PFD) on the development of postlaminectomy epidural fibrosis in a rat model.

Materials and methods: A total of 32 male Wistar albino rats were randomly assigned to four equal groups (n = 8 per group). A bilateral total L1–L2 laminectomy was performed using a posterior midline microsurgical approach. The control group received only laminectomy; the sterile saline (SF) group received laminectomy followed by irrigation with sterile saline; the topical pirfenidone (PFDTpc) group received laminectomy followed by topical PFD application at the laminectomy site; and the systemic pirfenidone (PFD-Sys) …


Lipopolysaccharide-Induced Acute Systemic Inflammation Is Associated With Depression-Like Behavior And Increased Hippocampal Epha4 Expression ​, Senem Esi̇n Yavaş, Özkan Yavaş, Ayşe Akbaş, Seda Işiklar, Semi̇ha Ersoy Oct 2026

Lipopolysaccharide-Induced Acute Systemic Inflammation Is Associated With Depression-Like Behavior And Increased Hippocampal Epha4 Expression ​, Senem Esi̇n Yavaş, Özkan Yavaş, Ayşe Akbaş, Seda Işiklar, Semi̇ha Ersoy

Turkish Journal of Medical Sciences

Background/aim: Depression is a prevalent neuropsychiatric disorder with a complex etiology and a higher burden in women. The inflammation hypothesis, initially proposed based on parallels between depression and sickness behavior, has gained increasing support from accumulating evidence. EphA4, a regulator of synaptic plasticity, is highly expressed in the hippocampus and functions as a negative modulator of neuroplasticity.

Materials and methods: Hippocampal EphA4 expression was investigated in female Wistar rats subjected to lipopolysaccharide-induced acute systemic inflammation. Acute systemic inflammation was induced by intraperitoneal administration of lipopolysaccharide (5 mg/ kg). Depression-like behaviors were assessed using the open-field test and tail-suspension test, while …


Effects Of Topical Glycerin And Hydrogen Peroxide On Auditory Brainstem Response Thresholds In A Rat Model Of Tympanic Membrane Perforation ​, Özlem Akkoca, Emi̇ne Aydin, Şule Demi̇rci̇, Ridvan Hali̇t Pamuk, Emi̇ne Ceren Ersöz Ünlü, Harun Çoban, Yüce İslamoğlu Oct 2026

Effects Of Topical Glycerin And Hydrogen Peroxide On Auditory Brainstem Response Thresholds In A Rat Model Of Tympanic Membrane Perforation ​, Özlem Akkoca, Emi̇ne Aydin, Şule Demi̇rci̇, Ridvan Hali̇t Pamuk, Emi̇ne Ceren Ersöz Ünlü, Harun Çoban, Yüce İslamoğlu

Turkish Journal of Medical Sciences

Background/aim: Cerumenolytic agents containing glycerin and hydrogen peroxide are widely used in clinical practice and are generally considered safe; however, their potential effects on hearing function in cases of tympanic membrane (TM) perforation have not been adequately investigated. This experimental study evaluated the potential ototoxic effects of glycerin and hydrogen peroxide in rats with TM perforations using auditory brainstem response (ABR) testing.

Materials and methods: Twenty healthy male Wistar albino rats with bilaterally induced near-total TM perforations were divided into four groups (n = 4–6 animals/group) and received topical saline, amikacin, glycerin, or hydrogen peroxide applications twice daily for 10 …


Psychological Distress Among Dental Students: A Comparative Study Of Preclinical And Clinical Stages ​, Ömer Faruk Sari, Eli̇f Albayrak, Muhammed Hi̇lmi̇ Büyükçavuş Oct 2026

Psychological Distress Among Dental Students: A Comparative Study Of Preclinical And Clinical Stages ​, Ömer Faruk Sari, Eli̇f Albayrak, Muhammed Hi̇lmi̇ Büyükçavuş

Turkish Journal of Medical Sciences

Background/aim: Understanding the degree of psychological stress experienced by dental students, together with the contributing factors, is important for reducing the adverse effects of stress and improving student well-being. Accordingly, the present study examined psychological distress levels among dental students and compared psychological distress across different academic years.

Materials and methods: This cross-sectional study included all undergraduate students enrolled in a single 5-year dental faculty in Türkiye during the 2024–2025 academic year. The Kessler Psychological Distress Scale (K10) survey was administered to the students and 399 dentistry students filled out the survey completely.

Results: Statistically significant differences in K10 scores …


Comments On “Pregnancy Outcomes In Systemic Sclerosis Before And After Diagnosis: A Retrospective Nationwide Cohort Study” ​, Muhammad Faisal Shabbir, Muksh Maheshwari, Chand Raj, Maria Baloch Oct 2026

Comments On “Pregnancy Outcomes In Systemic Sclerosis Before And After Diagnosis: A Retrospective Nationwide Cohort Study” ​, Muhammad Faisal Shabbir, Muksh Maheshwari, Chand Raj, Maria Baloch

Turkish Journal of Medical Sciences

No abstract provided.


Corrigendum To “Characterizing The Metabolites Of The Tyrosine-Kinase Inhibitor Pexidartinib In Mouse Feces, Urine, Plasma, And Liver” [J. Pharm. Biomed. Anal. 265 (2025) 117034], Xuan Qin, Si Chen, John M Hakenjos, Jian Wang, Lei Guo, Ashish Dogra, Zhaoyong Hu, Kevin R Mackenzie, Feng Li Oct 2026

Corrigendum To “Characterizing The Metabolites Of The Tyrosine-Kinase Inhibitor Pexidartinib In Mouse Feces, Urine, Plasma, And Liver” [J. Pharm. Biomed. Anal. 265 (2025) 117034], Xuan Qin, Si Chen, John M Hakenjos, Jian Wang, Lei Guo, Ashish Dogra, Zhaoyong Hu, Kevin R Mackenzie, Feng Li

Faculty, Staff and Students Publications

No abstract provided.


Multicentre Real-World Outcomes Of Reference Bevacizumab And Two Biosimilars In Treatment-Naïve Neovascular Age-Related Macular Degeneration ​, Eyüpcan Şensoy, Mehmet Çitirik, Burhan Başkan, Hasan Öncül, Abdullah Beyoğlu Oct 2026

Multicentre Real-World Outcomes Of Reference Bevacizumab And Two Biosimilars In Treatment-Naïve Neovascular Age-Related Macular Degeneration ​, Eyüpcan Şensoy, Mehmet Çitirik, Burhan Başkan, Hasan Öncül, Abdullah Beyoğlu

Turkish Journal of Medical Sciences

Background/aim: Bevacizumab biosimilars are increasingly used as alternatives to reference bevacizumab in ophthalmic practice, but comparative real-world evidence in treatment-naïve neovascular age-related macular degeneration (nAMD) remains limited. In this study, the short-term anatomical, functional, and documented safety outcomes associated with bevacizumab, bevacizumab-bvzr (Zirabev), and bevacizumab-awwb (Mvasi) were evaluated in treatment-naïve patients with nAMD in a multicentre real-world setting.

Materials and methods: This multicentre retrospective cohort included 250 treatment-naïve eyes with nAMD from 16 centres in Türkiye that completed a 3-month loading regimen with the same bevacizumab agent. Central macular thickness (CMT) was the prespecified primary longitudinal outcome; best-corrected visual acuity …


Interdisciplinary, Delphi-Driven Consensus Guidelines On The Use Of Intravenous Ketamine Infusions For Depressive Disorders From The American Society Of Ketamine Physicians, Psychotherapists, And Practitioners (Askp3), David S Mathai, Madeleine Cluck, Amna M Aslam, Erin Amato, Arsalan Azam, Michael Banov, Kathleen A Barrett, Carl J Bonnett, David Feifel, Nicolas Grundmann, H Samuel Ko, Rupert Mcshane, Sandhya Prashad, Tatiana Santini, Lowan H Stewart, Patrick Sullivan, Stefany D Wolfsohn, Jill O Robinson, Amy L Mcguire, L Alison Mcinnes Oct 2026

Interdisciplinary, Delphi-Driven Consensus Guidelines On The Use Of Intravenous Ketamine Infusions For Depressive Disorders From The American Society Of Ketamine Physicians, Psychotherapists, And Practitioners (Askp3), David S Mathai, Madeleine Cluck, Amna M Aslam, Erin Amato, Arsalan Azam, Michael Banov, Kathleen A Barrett, Carl J Bonnett, David Feifel, Nicolas Grundmann, H Samuel Ko, Rupert Mcshane, Sandhya Prashad, Tatiana Santini, Lowan H Stewart, Patrick Sullivan, Stefany D Wolfsohn, Jill O Robinson, Amy L Mcguire, L Alison Mcinnes

Center for Medical Ethics and Health Policy Staff Publications

Background: Off-label use of intravenous ketamine (IVK) for depression is a widespread practice with limited regulation in the United States. There is an urgent need for current, evidence-informed treatment guidelines to facilitate patient safety, clinical decision-making, and care quality in real-world contexts.

Methods: The American Society of Ketamine Physicians, Psychotherapists and Practitioners (ASKP3) convened an interdisciplinary working committee tasked with creating guidelines for use of IVK for depression in outpatient settings. Guideline development followed a two-stage process: 1) a hybrid systematic and targeted evidence review and preliminary drafting by the committee, and 2) consensus refinement through a modified Delphi method …


Intouch Week Of October 12, 2026, New York Medical College Oct 2026

Assessment Of The Impact Of A Snack Initiative Programme For Reduction Of Hospital-Acquired Malnutrition Among Nutritionally High-Risk Patients., Megha E. Jacob, Ciara O Connor, Sarah Wade Oct 2026

Assessment Of The Impact Of A Snack Initiative Programme For Reduction Of Hospital-Acquired Malnutrition Among Nutritionally High-Risk Patients., Megha E. Jacob, Ciara O Connor, Sarah Wade

International Undergraduate Journal of Health Sciences

Nutrition is an integral component of patient care and recovery. In Irish acute care, approximately 10,500 patients rely on hospital catering for their dietary intake. In 2024, an initiative was undertaken in Cork University Hospital (CUH) to assess staff compliance to snack rounds, staff knowledge, patient awareness and satisfaction of the snack range. Using a survey, phase 1 (n = 28) established baseline patient awareness of snack availability. As a result, strategies including staff education and increased ward- level signposting of snack resources were implemented. A repeat survey was conducted in Phase 2 (2025) (n = 30) to assess changes …


Intouch Week Of October 5, 2026, New York Medical College Oct 2026