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Taste-Masking: Function Of Exaggerated Prandial Drinking In Desalivate Mice, Richard C. Lewis

Journal of the Arkansas Academy of Science

Taste thresholds for the bitter compound sucrose octaacetate (SOA) were elevated by desalivation in mice. Thresholds were determined for control and experimental animals both before and after ligation of all salivary ducts. There was a significant increase in SOA thresholds in the desalivate mice, and the pre- to post-operative differences in threshold between the control and experimental groups were significant. The altered response to SOA by desalivate mice is shown to be due to the assumption of a prandial pattern of drinking as a result of desalivation. This conclusion is based on experiments with wet mash which failed to show …

Ua35/11 Student Honors Research Bulletin, Wku Honors Program

WKU Administration Documents

Papers representative of the variety of scholarly research conducted at WKU.

• Adams, Kathy. The Appalachian Language
• Barnett, Philip. A Study of Deviant Behavior of XYY Individuals in Regard to Environment and Genotype
• Bell, Brooks. Loving, Loyal Linda Loman: An Interpretive Note
• Danhauer, Janice. Motivating Workers Through Job Design
• Davis, Barbara. The Transformation of a Man into a Man of Understanding in Murinbata Society
• Davis, Diane. The Argot of the Homosexual
• Jewell, Teresa. The Life Story of the Hero of World War I - Sergeant Alvin C. York
• Lanham, Wayne. Das Knarrenschiff and a Ship of Fools: A Study in Influence …

1977 Vol. 3 No. 2, School Of Medicine Office Of Alumni Affairs

Medicinews

LSU Medicinews Volume 3 Number 2 was edited and published by the staff of the School of Medicine Editorial Office.

This issue consists of 8 pages. The publication date is September 1977.

The Pi System Of Alpha-L-Protease Inhibitor (Alpha-L-Antitrypsin) Biochemical Immunological And Genetic Studies In Health And Disease, Philippe Arnaud

MUSC Theses and Dissertations

The results of our personal studies of alpha-l-protease inhibitor (APi, formerly termed alpha-l-antitrypsin), the major inhibitor of protease in extracellular fluids, are presented in this dissertation. In the first chapter, we describe techniques used for APi quantitation and determination of Pi phenotypes. After a brief review of the available techniques, we report several improvements on our original technique of Pi phenotyping using thin-layer isoelectric focusing. Particular attention is given to biochemical and immunological methods for verification of the results obtained by isoelectric focusing. Three complementary techniques are reported: protease probe, crossed immunoelectrophoresis, and print immunofixation. Analysis of the results from …

Uptake Of Branched-Chain Alpha-Keto Acids In Bacillus Subtilis, Barry J. Goldstein, Stanley A. Zahler

Department of Medicine Faculty Papers

Bacillus subtilis has a constitutive system for the uptake of alpha-keto-beta-methylvalerate, alpha-ketoisovalerate, and (probably) alpha-ketoisocaproate. A mutation, kauA1, which blocks the uptake of alpha-keto-beta-methylvalerate and alpha-ketoisovalerate, is located between metB and citK on the B. subtilis chromosome.

Chemicals And Food: An Account About Additives, Wayland E. Noland

Journal of the Minnesota Academy of Science

Food additives are listed by functional category and discussed in terms of the scale of their use and relative risks in terms of long-term human toxicity. The greatest risks appear to lie with the antimicrobial preservative agents, and food colors (which serve only a cosmetic purpose); these and the synthetic sweeteners are discussed in relatively greater detail.

Chlorofluorocarbon Effects On Cardiac, Pulmonary, And Respiratory Patients, Mildred E. Olson

Journal of the Minnesota Academy of Science

Research results from studies of the physiological effects of aerosal propellants on animals and people are summarized. The papers selected for this summary were published between 1968 and 1975. Effects of the 15 chlorofluorocarbons used as propellants have been recorded on the cardiac, pulmonary and respiratory functions of a number of animal species as well as man. The fifteen propellants have been classified into four groups on the basis of their degree of toxicity. Fluorocarbon 11, the most frequently used propellant, is in group 1, the most toxic. The relative toxicity of each of the 14 other propellants compared with …

Measurement Of Permeability Of The Cell Membrane To Water, Richard Moore, Frederick Thornburgh, Donggyu Jin

Journal of the Minnesota Academy of Science

The water permeability was measured for blood cells from normal subjects and for blood cells from patients with leukemia. The method of measurement of the kinetics of water influx employed a stopped flow apparatus. The method of calculation of results was based on irreversible thermodynamics. The measurements and calculations were both performed with the assistance of a computer. The water permeability of the leukemic cells was decreased from normal, and the values were more variable than normal. Leukemia changes the structure of the cell membrane.

Stereospecific Opiate Binding In Human Erythrocyte Membranes And Changes In Heroin Addicts, Leo G. Abood, Holly G. Atkinson, Mary Macneil

Publications and Research

Stereospecific opiate binding has been demonstrated in human erythrocyte membranes, having a Kd of 9-10(-9) M. In most respects the binding characteristics resemble those of synaptic membranes. These included the correlation of binding affinity and pharmacological potency of opiates; competition by naloxone; inhibition by Ca2+ and Na+; and sensitivity to phospholipases and trypsin. A comparison of stereospecific opiate binding in control human subjects and heroin addicts revealed a 43% increase in the addict group.

Ultrastructure And Chemical Composition Of Microconidial Walls Of Trichophyton Mentagrophytes, Christine Da-Ruh Wu

Dissertations

No abstract provided.

Patterns Of Fatty Acid Release From Endogenous Substrates By Human Platelet Homogenates And Membranes, A Derksen, P Cohen

Faculty, Staff and Students Publications

We describe a method for measuring the release of fatty acids from endogenous substrates of human platelet homogenates and membranes. The method depends on the availability of lipids whose fatty acids are odd-chained and therefore suitable as internal reference compounds that, at the time of lipid extraction, can be added to an incubation to permit subsequent quantification of the content of free fatty acids or fatty acids esterified to specific lipids. We found four types of lipolytic activities in human platelets. In homogenates at pH 4.0 a triglyceride lipase operated as shown by the synchrony of triglyceride degradation and release …

Atomic Models For The Polypeptide Backbones Of Myohemerythrin And Hemerythrin, W A Hendrickson, K B Ward

Faculty, Staff and Students Publications

Background: The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread rapidly after its identification in December 2019 to cause a global pandemic. The respiratory tract is the primary site of infection, and there is a large range in the severity of respiratory illnesses caused by the virus. Defining molecular and cellular factors for protection from severe disease and death has been a goal to better understand and to predict and mitigate the effects of SARS-CoV-2 and future coronaviruses.

Objective: Despite well-known susceptibilities to respiratory viral infections, respiratory allergy and allergic asthma have not been identified as risk factors …

An Analysis Of Blood Cortisol Levels In Oral Surgery Patients Under Various Levels Of Intravenous Medication, Fred L. Bunch

Loma Linda University Electronic Theses, Dissertations & Projects

This study was designed to objectively evaluate each pharmacological component of the Loma Linda intravenous sedation technique. The results were evaluated as a function of stress as measured by plasma cortisol levels.

The study was conducted on fifty patients in groups of ten. Blood samples were taken at set procedure intervals during dental extraction of third molar teeth. A component of the Loma Linda technique was deleted from each of the groups to ascertain its role in sedation and relief of stress.

Results show a trend toward reduction of plasma cortisol levels as the procedure progresses, indicating a measure of …

The Effect Of A Pufa Diet On Human Red Blood Cell Levels Of 2, 3-Dpg, Sandra A. Dassenko

Loma Linda University Electronic Theses, Dissertations & Projects

Fasting blood was collected at weekly intervals and the level of 2,3-DPG of the red blood cell was determined in 15 male subjects age 28 to 57 with serum cholesterol levels greater than 250 mg%. A lactovegetarian diet containing no cholesterol, a high level of dietary fiber and a P/S ratio of 4.0 was provided for 28 days.

During the course of the experimental period the 2,3-DPG increased by an average of 0.83> «moles/ml red blood cell which was highly significant (p^.001). This significant increase of 2,3-DPG which relates to an increased oxygen delivery capability of the red blood cells …

Bibliography Of Secondary Sources On The History Of Dermatology Ii. Obituaries And Biographies In English Before 1973, Lawrence Charles Parish, M.D., John Thorne Crissey, M.D., Jennifer L. Parish, M.D., Daniel H. Parish, J.D.

Department of Dermatology and Cutaneous Biology Faculty Papers

Bibliography of Secondary Sources on the History of Dermatology

II. Obituaries and Biographies in English before 1973

The Xyy Syndrome And The Judicial System, Paul Cheverie

North Carolina Central Law Review

No abstract provided.

Effect Of Speed Of Muscle Contraction On Strength Improvement, Terry Alan Dieckhoff

Masters Theses

No abstract provided.

Faculty Publications July 1971 - Dec 1972, Lsu Health Sciences Center New Orleans

Historical Faculty Publications

This Faculty bibliography contains 437 publications.

Value Of Oxygen With Innovar And Methohexital For Outpatient Oral Surgery, Andrew D. Harsany

Loma Linda University Electronic Theses, Dissertations & Projects

This paper demonstrates the value of oxygen in maintaining arterial blood gas in an adequate range during outpatient oral surgery. Dental extractions were completed on ten patients under an anesthetic technique utilizing Innovar and methohexital with supplemental nasal oxygen. Blood gas samples were drawn at five stages during the procedure.

The mean of the PaO₂ samples drawn with the patient at the point of deepest sedation was approximately three times the normal value.

Oxygen for pulmonary ventilation provides a reservoir in the lungs, saturation of hemoglobin, and increased oxygen in the plasma which provides a margin of safety if …

The Effect Of Glucose On The Food Intake Of Goldthioglucose Injected Mice, Janet Lahti

Dissertations and Theses

Jean Mayer has postulated the presence of glucoreceptors located primarily in the ventromedial hypothalamic nuclei of the brain which are activated by glucose in the measure that they utilize it. According to Mayer, hunger occurs when glucose is not available for metabolic purposes and satiation supervenes when glucose is made available. Control of this mechanism rests with the glucoreceptors. These receptors are believed to be destroyed when an injection of the compound goldthioglucose is given to mice. These animals subsequently become obese and are found to have gold deposits and lesions in the ventromedial area and also in other parts …

Mathematical Model Of Placental Oxygen And Carbon Dioxide Exchange, Ester P. Hill

Loma Linda University Electronic Theses, Dissertations & Projects

This model of placental CO₂ and O₂ exchange calculates the time course of changes in P_^CO2, [HCO₃^-], and [H⁺] in each of four "compartments" of placental exchange vessels: maternal erythrocytes, maternal plasma, fetal plasma and fetal erythrocytes. The changes in hemoglobin-bound CO₂ (carbamate) and oxyhemoglobin contents within the erythrocytes are also calculated, permitting consideration of the Haldane and Bohr effects. Equations were written to represent one-dimensional steady state CO₂ and O₂ diffusion between concurrent maternal and fetal capillaries and the subsequent hydration, carbamino and oxyhemoglobin reactions. The equations …

Effect Of Lateral Positioning On Central Venous Pressure, Romelda C. Jereos

Loma Linda University Electronic Theses, Dissertations & Projects

This experimental study was conducted to investigate the effects of lateral positioning on central venous pressure. It was hypothesized that lateral positioning would not significantly change the central venous pressure so long as the subjects were placed on the same horizontal plane for both supine and lateral measurements. It was also hypothesized that the length of time spent in the lateral position would not alter the pressure.

It is recognized that several factors do indeed play important roles in the maintenance of central venous pressure. The effect of one particular influencing factor, gravity, was central to this study. The difference …

An Anesthetic Technique Utilizing Innovar, Fentanyl, And Methohexital Sodium For Outpatient Oral Surgery, Fredric D. Haerich

Loma Linda University Electronic Theses, Dissertations & Projects

A study of 800 patients ranging in age from seven to one hundred years was conducted in the development of an anesthetic technique which combines the desirable qualities of a neuroleptic agent with the requirements of an outpatient oral surgical anesthetic. These requirements included rapidity of onset, effectiveness of action, ease of controlling duration, and rapid postoperative recovery.

Patients who were cleared medically for outpatient procedures were given Innovar 1.5 cc/150 lb of body weight, atropine 0.4 mg, and fentanyl 1.0 cc/150 lb of body weight as an initial dose within 30-45 seconds in a D5W drip by means of …

A Follow-Up Study Of Patients With Chronic Obstructive Lung Disease And Their Practice Of The Breathing Pattern, A. Theodora Djagia

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this descriptive survey was to do a follow-up study on patients with COPD to find out to what extent these patients have followed instruction to continue exercising the abdominal and diaphragmatic muscles, with the utilization of a breathing pattern. Literature was reviewed which revealed contradictory findings in regard to the physiological benefits of the use of the breathing pattern. Nine patients met the criteria and signed a consent sheet to be visited in their homes. An Observation Data Sheet and Interview Guide were the tools used to collect data. A point system was constructed and used with …

An Investigation Of Cerebrovascular Factors In Head Injury: A Multifaceted Multidisciplinary Approach. Nih Proposal For A Head Injury Center At Loma Linda University, George M. Austin

The Dr. George M. Austin Neurology Research Collection

An Investigation of Cerebrovascular Factors in Head Injury: A Multifaceted Multidisciplinary Approach. NIH proposal for a Head Injury Center at Loma Linda University. George Austin.

1. Typewritten letter. G.A. to Matilda Solowey, Extra Mural Programs, National Institutes of Health, Washington D.C., May 30, 1970. 1 pg.
2. “Head Injury Center; Supplement to: An Investigation of Cerebrovascular Factors in Head Injury: A Multifaceted Multidisciplinary Approach,” 14 pg.
3. “Specialized Clinical Research Head Injury Center, Loma Linda University School of Medicine, Loma Linda, California, George M. Austin, M.D., Professor of Neurosurgery, Additional Supporting Bibliography,” 1 p. Contains entries 90-97.
4. “Cerebral Blood Flow Changes in Vasospasm …

A Study To Demonstrate The Immediate Destination Of An Embolus Formed In The Lumen Of A Peripheral Venous Catheter, Rosemarie Morikone Emori

Loma Linda University Electronic Theses, Dissertations & Projects

This study was designed to show the immediate destination of an embolus formed in the lumen of an intravenous catheter placed in a peripheral vessel. The hypothesis stated that clots injected into a peripheral vessel will lodge in the lungs. A subhypothesis was that the clot may lodge anywhere along the circulatory pathway.

Indications of need for the study as shown by the review of literature were the following: (1) the complications resulting from the frequent use of intravenous polyethylene catheters, (2) experimental studies that showed that clots were formed around intravenous catheters, (3) the evidence that intravenous catheters predispose …

Some Aspects Of Carbohydrate Metabolism In The Cercariae Of Schistosoma Mansoni Sambon, 1907, A. Eugene Dunham Jr.

Loma Linda University Electronic Theses, Dissertations & Projects

Cercariac of Schistosoma mansoni were studied for glycogen utilization, uptake of glucose from solution, lactic acid production, and respiration.

Using the anthrone method of determination of carbohydrate, the amount of glycogen used by a single cercaria in 4 hours is determined as 43.2 x 10^-4 μg ± 6.6 x 10^-4 μg.

Glucose was not observed to have been used from solution under the conditions of the experiment, even in the presence of trehalose. The determinations were made by the Glucostat method.

After deproteinization and desugarization, aliquots of supernatant from cercarial suspensions were analyzed for lactic acid using p-phenylphenol …

The Esophageal Propulsive Force: Esophageal Response To Acute Obstruction, Daniel H. Winship, F. Frank Zboralske

Biomedical Sciences Faculty Research and Publications

The response of the normal human esophagus to an obstructing intraluminal bolus was investigated and compared to the response evoked by transient intraluminal distention. A balloon, immobilized within the esophagus by external attachment to a force transducer, was inflated with from 3 to 25 ml of air for from 3 to 210 sec. Pressure phenomena occurring in the esophagus were simultaneously recorded from the body of the esophagus above and below the balloon.

Transient distention (5 sec or less) with small volumes (5 ml or less) often evoked a secondary peristaltic wave in the esophagus distal to the balloon, but …

The Effects Of Particular Sounds On Certain Indices Of Cardio-Pulmonary Functions, Harold F. Googe, Jane Mundin

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to identify the effects of particular sounds upon certain indices of cardio-pulmonary function and the degree and pattern of changes which occurred in the indices. The specific physiological parameters chosen to be monitored were heart rate, respiratory rate, mean tidal volume, instantaneous minute volume, and oxygen consumption. The hypothesis was that particular sounds will cause changes in certain indices of cardio-pulmonary functions. This was a controlled experiment, in which nine healthy males and nine healthy females, of a denominational, medically oriented University listened to a specially constructed tape of background music interspersed with an …

Studies Of The Mechanism By Which Chronic Metabolic Acidosis Augments Urinary Calcium Excretion In Man, Jacob Lemann Jr., John R. Litzow, Edward J. Lennon

Biomedical Sciences Faculty Research and Publications

We carried out clearance studies in nine healthy adults and four patients with hypoparathyroidism before and after inducing stable metabolic acidosis with either NH₄Cl or acetazolamide. Clearances were repeated in seven normal subjects and three of the patients 3 days after stopping these agents.

During acidosis in the normal subjects, serum ultrafilterable calcium concentration rose significantly, but inulin clearance fell to a greater extent, so that the calculated filtered load of calcium fell significantly. Despite this, urinary calcium excretion rose. Urinary calcium excretion remained elevated in the recovery studies when the serum ultrafilterable calcium concentration and filtered load …