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Epigenetics: Blurring The Line Between Nature And Nurture, Elizabeth H. Rose Jan 2010

Epigenetics: Blurring The Line Between Nature And Nurture, Elizabeth H. Rose

CMC Senior Theses

This long-standing nature versus nurture debate is cited in behavioral and physical expressions of disease dysfunctions, resiliencies, and recovery. Their purposes are noted both in scientific pursuits as well as literature. This discourse has been particularly intense in the fields of psychology, psychiatry, and biology where there is a long history of scientists’ attempts to disprove or discredit others’ intellectual and professional measures. Interestingly, recent advances in the neurosciences and genetic technologies have brought these fields closer together with a new focus – the interactional relationship between nature and nurture – epigenetics.

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Investigation Of Residues Of The Vesicular Stomatitis Virus Nucleocapsid Protein That Affect Transcription And Rna Replication, Djamila Harouaka Jan 2010

Investigation Of Residues Of The Vesicular Stomatitis Virus Nucleocapsid Protein That Affect Transcription And Rna Replication, Djamila Harouaka

All ETDs from UAB

The template for transcription and RNA replication for vesicular stomatitis virus (VSV) and other negative-strand RNA viruses is a ribonucleoprotein (RNP) complex consisting of the viral RNA genome and associated nucleocapsid (N) protein. The structure of the RNP-like complex of VSV showed that the RNA is sequestered between two lobes of the N protein, and adjacent N monomers are linked by an extensive network of interactions. Long-range interactions mediated by the N-terminal arm and C-terminal loop of the N protein stabilize the side-to-side contacts between adjacent N monomers, and are required for RNA encapsidation. It is unclear how the polymerase …

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Pneumococcal Vaccine Response And Aging In Human, Saeyoung Park Jan 2010

Pneumococcal Vaccine Response And Aging In Human, Saeyoung Park

All ETDs from UAB

Streptococcus pneumoniae is a major human pathogen, especially for young children and older adults. To protect from pneumococcal diseases, 23-valent pneumococcal polysaccharide vaccine (PPV23) has been used clinically since 1983. However, PPV23 is not so effective among old adults with its protective efficacy diminishing with age. We confirmed that young and old adults, who were immunized with PPV23, have comparable pneumococcal polysaccharide (PS) specific IgG levels. Interestingly, we found that old adults had lower IgA and IgM antibody levels than young adults for three serotypes (serotype 14, 18C and 23F). Consistent with the previous results, opsonic capacities of immune sera …

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In Remembrance Of Denis Alan Trevor New, Robert L. Brent Dr. Jan 2010

In Remembrance Of Denis Alan Trevor New, Robert L. Brent Dr.

The Selected Works of Robert Brent

None

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Expression Of The Intestinal Biomarkers Guanylyl Cyclase C And Cdx2 In Poorly Differentiated Colorectal Carcinomas., Brody Winn, Rosemarie Tavares, Andres Matoso, Lelia Noble, Jacqueline Fanion, Scott A Waldman, Murray B Resnick Jan 2010

Expression Of The Intestinal Biomarkers Guanylyl Cyclase C And Cdx2 In Poorly Differentiated Colorectal Carcinomas., Brody Winn, Rosemarie Tavares, Andres Matoso, Lelia Noble, Jacqueline Fanion, Scott A Waldman, Murray B Resnick

Department of Pharmacology and Experimental Therapeutics Faculty Papers

Guanylyl cyclase C, a receptor for bacterial diarrheagenic enterotoxins, is expressed selectively by intestinal epithelium and is an endogenous downstream target of CDX2. The expression of Guanylyl cyclase C is preserved throughout the adenoma/carcinoma sequence in the colorectum. Detection of Guanylyl cyclase C expression by reverse transcriptase-polymerase chain reaction is currently being validated as a technique to identify occult lymph node metastases in patients with colorectal cancer and for circulating cells in the blood for postoperative surveillance. Although Guanylyl cyclase C is widely expressed by well-differentiated colorectal cancer, its expression in poorly differentiated colorectal cancer has not been evaluated. A …

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The Distribution Of Telomerase Activity In Patients With Helicobacter Pylori Positive Gastritis, Nai̇me Canoruç, Ebru Kale, Şeri̇f Yilmaz, Kadi̇m Bayan, Mehmet Dursun, Sabri̇ Batun, Abdurrahman Kaplan Jan 2010

The Distribution Of Telomerase Activity In Patients With Helicobacter Pylori Positive Gastritis, Nai̇me Canoruç, Ebru Kale, Şeri̇f Yilmaz, Kadi̇m Bayan, Mehmet Dursun, Sabri̇ Batun, Abdurrahman Kaplan

Turkish Journal of Medical Sciences

Helicobacter pylori is considered a class I carcinogen by the World Health Organization. We aimed to determine whether H. pylori has an effect on telomerase activity in patients with H. pylori related non-specific gastritis, atrophy, and intestinal metaplasia. Materials and methods: One hundred and seventy-two adult patients who underwent upper gastroduodenoscopy were enrolled in the study. Three biopsy specimens were taken from the antrum: 1 from the incisura angularis and 2 from the mid-antrum. Biopsy specimens taken from the incisura angularis were evaluated using the urease test for detection of H. pylori. The mid-antrum specimens were sent for histopathology and …

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The Relationship Between Daily Caffeine Consumption And Withdrawal Symptoms: A Questionnaire-Based Study, Nermi̇n Küçer Jan 2010

The Relationship Between Daily Caffeine Consumption And Withdrawal Symptoms: A Questionnaire-Based Study, Nermi̇n Küçer

Turkish Journal of Medical Sciences

To estimate daily caffeine intake among a group of university students at the Kocaeli Vocational School of Health Services in Turkey, and to determine the relationship between daily caffeine consumption and withdrawal symptoms. Materials and methods: This survey study was conducted using a questionnaire that was administered to 156 university students (129 females, 27 males) at the Kocaeli Vocational School of Health Services in Kocaeli, Turkey. The quantity of caffeine-containing products consumed was recorded on a daily basis, depending on the dietary habits of the consumer. The t test for differences between 2 proportions (using the normal approximation) was used …

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Asymptomatic Carriage Of Bacteria In Food Workers In Nilüfer District, Bursa, Turkey*, Kayihan Pala, Cüneyt Özakin, Nalan Akiş, Melda Sinirtaş, Suna Gedi̇koğlu, Hamdi̇ Ayteki̇n Jan 2010

Asymptomatic Carriage Of Bacteria In Food Workers In Nilüfer District, Bursa, Turkey*, Kayihan Pala, Cüneyt Özakin, Nalan Akiş, Melda Sinirtaş, Suna Gedi̇koğlu, Hamdi̇ Ayteki̇n

Turkish Journal of Medical Sciences

This study was carried out in order to determine the nasal carriage of Staphylococcus aureus and the faecal carriage of Salmonella spp., Shigella spp., Yersinia enterocolitica, Listeria monocytogenes, and Escherichia coli O157:H7 in food industry workers. Materials and methods: During the study, face to face interviews were conducted with the workers and 9-item questionnaires regarding demographic information, working time, and periodical medical examinations were administered. In the study nasal swab specimens of 1115 individuals and faecal specimens of 1061 individuals were bacteriologically investigated. Results: The nasal carriage of methicillin-resistant Staphylococcus aureus (MRSA) was found to be significantly more common in …

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Anti-Diabetic Activity Of Tinospora Cordifolia (Willd.) In Streptozotocin Diabetic Rats; Does It Act Like Sulfonylureas?, Nagaraja Puranik, Kararashah Fakruddin Kammar, Sheela Devi Jan 2010

Anti-Diabetic Activity Of Tinospora Cordifolia (Willd.) In Streptozotocin Diabetic Rats; Does It Act Like Sulfonylureas?, Nagaraja Puranik, Kararashah Fakruddin Kammar, Sheela Devi

Turkish Journal of Medical Sciences

As an alternative medicine to treat diabetes mellitus, many herbal drugs are being studied throughout the world. In the present study, an attempt was made to investigate the anti-diabetic activity of Tinospora cordifolia (Willd.) (TC) stem extracts (both aqueous and alcoholic) in different dosages (200 and 400 mg/kg b.w.) in streptozotocin diabetic albino rats. The probable mechanism by which TC may act as an anti-hyperglycemic drug was also investigated. Materials and methods: The drug was administered orally for 10 days and 30 days in different groups of animal, with each group containing 6 animals. The efficacy of this drug was …

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X-Ray Diffraction Analysis Of Urinary Tract Stones, Turgut Yapanoglu, Azam Demi̇rel, Şenol Adanur, Hi̇kmet Yüksel, Özkan Polat Jan 2010

X-Ray Diffraction Analysis Of Urinary Tract Stones, Turgut Yapanoglu, Azam Demi̇rel, Şenol Adanur, Hi̇kmet Yüksel, Özkan Polat

Turkish Journal of Medical Sciences

To analyze urinary tract stones obtained in our clinic using various methods and to determine the spectrum of stone composition in the Eastern Anatolia Region, Turkey. Materials and methods: A total of 300 stones were obtained at Atatürk University, Faculty of Medicine Urology Clinic through open surgery, percutaneous nephrolithotomy (PNL), ureterorenoscopy (URS), and extracorporeal shock-wave lithotripsy (ESWL) between 1 January 2005 and 30 December 2008. Stones were analyzed in the laboratory of Ankara General Directorate of Mineral Research Exploration using X-ray diffraction (XRD). Results: It was found that 218 (72.7%) of the 300 stones were calcium oxalate (CaOx); 170 (56.7%) …

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Insertions Of The Lateral Pterygoid Muscle To The Disc-Capsule Complex Of The Temporomandibular Joint And Condyle, Cenk Kiliç, Gühan Dergi̇n, Fati̇h Yazar, Bülent Kurt, Tunç Kutoğlu, Hasan Ozan, Hüseyi̇n Avni̇ Balcioğlu Jan 2010

Insertions Of The Lateral Pterygoid Muscle To The Disc-Capsule Complex Of The Temporomandibular Joint And Condyle, Cenk Kiliç, Gühan Dergi̇n, Fati̇h Yazar, Bülent Kurt, Tunç Kutoğlu, Hasan Ozan, Hüseyi̇n Avni̇ Balcioğlu

Turkish Journal of Medical Sciences

To investigate the disc-capsule complex and condyle attachments of the lateral pterygoid muscle and its variations. Materials and methods: Forty-nine temporomandibular joint (TMJ) specimens were used, obtained from 26 human cadavers. The insertion point of each muscle head was determined. The widths and lengths of the heads were measured. Results: In 32 specimens, 2-headed muscles were present, while 3 heads were observed in 17 specimens. We defined 4 different types of attachments of muscle heads. In the most common type of attachment, the upper head inserted into the disc-capsule complex and condyle, and the lower head inserted into the condyle …

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An Application Of Nonlinear Canonical Correlation Analysis On Medical Data, Ayşe Canan Yazici, Ersi̇n Öğüş, Handan Ankarali, Fi̇kret Gürbüz Jan 2010

An Application Of Nonlinear Canonical Correlation Analysis On Medical Data, Ayşe Canan Yazici, Ersi̇n Öğüş, Handan Ankarali, Fi̇kret Gürbüz

Turkish Journal of Medical Sciences

In studies in the field of medicine, necessity to examine the relations between data sets composed of categorical variable groups is widely encountered. In this study, it was aimed to examine nonlinear canonical correlation analysis (OVERALS) method, which allows examination of relations among K number of categorical variable sets and structural similarities of the data set, and to discuss usefulness of the method in more comprehensive data sets obtained from studies carried out in the field of medicine in terms of practice and interpretation. Materials and methods: OVERALS method was applied to a part of data set obtained from a …

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Effects Of Grape Consumption On Plasma And Erythrocyte Antioxidant Parameters In Elderly Subjects, Aslihan Avci, Tesli̇me Atli, İmge B. Ergüder, Murat Varli, Erdi̇nç Devri̇m, Özgür Demi̇r, İlker Durak, Murat Turgay Jan 2010

Effects Of Grape Consumption On Plasma And Erythrocyte Antioxidant Parameters In Elderly Subjects, Aslihan Avci, Tesli̇me Atli, İmge B. Ergüder, Murat Varli, Erdi̇nç Devri̇m, Özgür Demi̇r, İlker Durak, Murat Turgay

Turkish Journal of Medical Sciences

To investigate the effects of ingesting Fructus vitis minuta (black grape) on plasma and erythrocyte antioxidant parameters in elderly subjects. Materials and methods: Thirteen subjects (mean age 74.67 ± 0.58) participated in the study. They consumed 1 g/kg body weight per day of dried black Maraş grapes for 1 month. Before and after these periods, fasting blood samples were obtained, and oxidant (as MDA) and antioxidant (as SOD) parameters were studied in erythrocytes. Also, plasma samples were obtained from the subjects. Results: In the erythrocyte hemolysate, MDA (malondialdehydes) levels and SOD (superoxide dismutase) activities were found to be lower (P < 0.01) in the second samples compared to the first ones. Conclusion: We think that because free radical production was decreased SOD activities were not increased. Our results show that reduced peroxidation processes caused by Maraş grape consumption suggest that grape consumption has beneficial effects in elderly subjects.

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Investigation Of Premenstrual Syndrome And Contributing Factors Among University Students*, Nülüfer Erbi̇l, Ayşenur Karaca, Tülay Kiriş Jan 2010

Investigation Of Premenstrual Syndrome And Contributing Factors Among University Students*, Nülüfer Erbi̇l, Ayşenur Karaca, Tülay Kiriş

Turkish Journal of Medical Sciences

To determine the frequency of premenstrual syndrome (PMS) and to investigate contributing factors for PMS among female students in a university dormitory in Ordu. Materials and methods: This descriptive study was conducted with female students at a public university dormitory in Ordu, in the East Black Sea region of Turkey. The sample contained 300 female students at the university dormitory. The study was conducted between 3 January and 12 January 2007. The research data were collected via a 22-item socio-demographic information questionnaire and the Premenstrual Syndrome Scale (PMSS) developed by Gençdoğan. Results: It was determined that the participants' mean age …

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The Prevalence Of Home Injuries Among Elderly People In Samsun, Turkey, And The Influencing Factors, Hülya Doğan, Sevgi̇ Canbaz, Berna Tander, Yildiz Pekşen, Ferhan Cantürk, Ni̇met Özal Oruç Jan 2010

The Prevalence Of Home Injuries Among Elderly People In Samsun, Turkey, And The Influencing Factors, Hülya Doğan, Sevgi̇ Canbaz, Berna Tander, Yildiz Pekşen, Ferhan Cantürk, Ni̇met Özal Oruç

Turkish Journal of Medical Sciences

Home injuries are a serious public health problem for the elderly. Our aim was to investigate the prevalence of home injuries among elderly people in Samsun, Turkey, and the influencing factors. Materials and methods: This cross-sectional study was conducted between 1 January and 28 February 2007. A questionnaire, the Home-Screen Scale (HSS), and the Geriatric Depression Scale (GDS) were administered to the elderly subjects. Results: Of all participants, 20.6% had experienced some kind of home injury. Seven participants living alone and 14 living with their families had suffered home injuries, suggesting a statistically significant difference between these 2 groups (P < 0.05). Eleven (14.7%) subjects living in secure housing and 10 (37.0%) living in unsecure housing had suffered home injuries, the difference again being statistically significant (P < 0.05). Conclusion: Home injuries are more common among people living alone and in unsecure housing according to the HSS.

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Thyroid Hormone Reference Intervals And The Prevalence Of Thyroid Antibodies, Aydan Çelebi̇ler, Si̇bel Bi̇lgi̇li̇, Emi̇ne Ömür Erkizan, Huri̇ye Seri̇n, Muhammet Baysal Karaca Jan 2010

Thyroid Hormone Reference Intervals And The Prevalence Of Thyroid Antibodies, Aydan Çelebi̇ler, Si̇bel Bi̇lgi̇li̇, Emi̇ne Ömür Erkizan, Huri̇ye Seri̇n, Muhammet Baysal Karaca

Turkish Journal of Medical Sciences

To establish new reference intervals for thyrotropin (TSH), free thyroxine (FT4), and free triiodothyronine (FT3) on the Beckman Coulter DxI 800 in healthy Turkish adults and assess the prevalence of laboratory evidence of thyroid antibodies in this population. Materials and methods: Specimens were obtained from 619 healthy volunteers (338 females, 281 males).The study was conducted with health care professionals and their relatives, The mean age of all the subjects was 34.7 and the median was 31 years, with ages ranging from 15 to 84. Moreover, the subjects had no evidence of thyroid autoimmunity or a history of drug use, both …

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The Effects Of 3-Benzoyl-1-Methyl-4-Phenyl-4 Piperidinolhydrochloride (C1), Indomethacin, Nimesulide And Rofecoxib On Cyclooxygenase Activities In Carrageenan-Induced Paw Edema Model, Yaşar Nuri̇ Şahi̇n, Berna Demi̇rcan, Hali̇s Süleyman, Hülya Aksoy, Hali̇se İnci̇ Gül Jan 2010

The Effects Of 3-Benzoyl-1-Methyl-4-Phenyl-4 Piperidinolhydrochloride (C1), Indomethacin, Nimesulide And Rofecoxib On Cyclooxygenase Activities In Carrageenan-Induced Paw Edema Model, Yaşar Nuri̇ Şahi̇n, Berna Demi̇rcan, Hali̇s Süleyman, Hülya Aksoy, Hali̇se İnci̇ Gül

Turkish Journal of Medical Sciences

The aim of this study was to investigate the effects of 3-benzoyl-1-methyl-4-phenyl-4-piperidinol-hydrochloride (C1), which is a structural and also non-classical isomer of bis Mannich base, bis (3-aryl-3-oxo-propyl) methylamine hydrochlorides (B1), on cyclooxygenase (COX) activities in 48 rats with inflammation by using carrageenan-induced paw edema, and to compare its effect with other non-steroidal anti-inflammatory drugs (NSAIDs). Materials and methods: Experimental animals were supplied by the Center of Experimental Research and Practice in Ataturk University. The animals were housed and fed in the laboratory (normal room temparature, food and water) under standard conditions. Rats were randomly assigned to eight groups (n = …

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Adrenergic And Cholinergic Responses Of The Tracheal Smooth Muscle Is Enhanced During Estrus Phase In Rat, M. Kasim Çayci, Yasemi̇n Aydin, Kubi̇lay Uzuner Jan 2010

Adrenergic And Cholinergic Responses Of The Tracheal Smooth Muscle Is Enhanced During Estrus Phase In Rat, M. Kasim Çayci, Yasemi̇n Aydin, Kubi̇lay Uzuner

Turkish Journal of Medical Sciences

The aim of this study was to evaluate influences of hormonal changes during rat estrous cycle on airway responsiveness to bronchoconstrictor and bronchodilator agents. Materials and methods: The study was performed in 5 groups of rat tracheal smooth muscle obtained during proestrus, estrus, metestrus, and diestrus phases of the estrous cycle, as well as the ovariectomized group (n:8/group). Cumulative acetylcholine contractions ranging from 10^{-8} to 10^{-3} M bath doses and the cumulative isoproterenol relaxations ranging from 10^{-8} to 10^{-3} M precontracted with 10^{-5} M of acetylcholine were recorded on isolated tracheas placed in a computerized tissue bath system. Results: Acetylcholine-induced …

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Evaluation Of Oxidant/Antioxidant Status And Ecp Levels In Asthma, Ömer Emecen, Berri̇n Berçi̇k İnal, Füsun Erdenen, Murat Usta, Hale Aral, Güvenç Güvenen Jan 2010

Evaluation Of Oxidant/Antioxidant Status And Ecp Levels In Asthma, Ömer Emecen, Berri̇n Berçi̇k İnal, Füsun Erdenen, Murat Usta, Hale Aral, Güvenç Güvenen

Turkish Journal of Medical Sciences

Inflammatory and immune cells, such as eosinophils, macrophages, and neutrophils, generate more reactive oxygen species in patients with asthma than they do in healthy individuals, and oxygen radicals contribute to tissue injury in asthma. We aimed to measure total oxidant status (TOS) and antioxidant status (TAS) in order to assess oxidative and antioxidative capacity. Eosinophil cationic protein (ECP), total IgE, and eosinophils (%) were measured to evaluate the level of inflammation. Materials and methods: The study included 56 non-smoking asthma patients that were followed-up at the respiratory disease and allergy outpatient clinics, where they received ongoing treatment for 5 months …

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Dermatoglyphics As Markers Of Prenatal Disturbances In Schizophrenia: A Case-Control Study, Bi̇rsen Özyurt, Ahmet Songur, Mustafa Sarsilmaz, Ömer Akyol, Mustafa Namli, Reha Demi̇rel Jan 2010

Dermatoglyphics As Markers Of Prenatal Disturbances In Schizophrenia: A Case-Control Study, Bi̇rsen Özyurt, Ahmet Songur, Mustafa Sarsilmaz, Ömer Akyol, Mustafa Namli, Reha Demi̇rel

Turkish Journal of Medical Sciences

Several studies have reported the importance of dermatoglyphics as markers of a prenatal disturbance in patients with schizophrenia. Due to the fact that finger- and handprints are formed by the end of the second trimester, they may provide clues to disturbances in early development. The aim of this study was to determine specific dermatoglyphical frequencies in a sample of patients with schizophrenia and normal controls. Materials and methods: Fingerprints and palm prints were obtained from 45 schizophrenic patients as well as 45 healthy controls. The dermatoglyphic patterns on the fingers (total finger ridge count [TFRC]) and palms (a-b, b-c, and …

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Evaluation Of Coping Strategies, Social Support, And Depressive Symptoms In Spouses Of Patients With Hematological Cancer, Safi̇ye Özkan, Yasemi̇n Kutlu Jan 2010

Evaluation Of Coping Strategies, Social Support, And Depressive Symptoms In Spouses Of Patients With Hematological Cancer, Safi̇ye Özkan, Yasemi̇n Kutlu

Turkish Journal of Medical Sciences

The purpose of this study was the evaluation of coping strategies, social support, and depressive symptoms in spouses of patients with hematological cancer. Materials and methods: A descriptive design was used in current study. The study was carried out at the hematology clinic of 2 university hospitals located in İstanbul. The convenience sample consisted of 150 spouses of patients who had hematological cancer. The data were collected through structured face-to-face interviews using a questionnaire form, the "Ways of Coping" Questionnaire, the Multidimensional Perceived Social Support Scale, and Beck Depression Inventory. Percentage t-tests and Pearson's product moment correlation were used to …

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Nitric Oxide And Trace Metals In Relation To Haemoglobin F Concentration In Nigerian Sickle Cell Disease Patients, John Ayodele Olaniyi, Olatubosun Ganiyu Arinola Jan 2010

Nitric Oxide And Trace Metals In Relation To Haemoglobin F Concentration In Nigerian Sickle Cell Disease Patients, John Ayodele Olaniyi, Olatubosun Ganiyu Arinola

Turkish Journal of Medical Sciences

Sickle cell disease (SCD) is an inherited haemoglobin (Hb) disorder associated with vaso-occlusive events, oxidative stress, high energy demand, and endothelial dysfunction. The endothelium plays a central role in the regulation of vascular homeostasis by releasing nitric oxide (NO) among other factors. Therefore, the objective of this study was to measure plasma levels of NO, trace metals, and HbF in SCD patients. Materials and methods: Plasma levels of NO, Zn, Mg, Mn, Se, Cu, Fe, Haemoglobin F (HbF) were measured in 59 steady state SCD patients referred to the Department of Haematology, University College Hospital, Ibadan, Nigeria and 35 age/sex …

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Cellular And Molecular Dissection Of Pluripotent Adult Somatic Stem Cells In Planarians, Norito Shibata, Labib Rouhana, Kiyokazu Agata Jan 2010

Cellular And Molecular Dissection Of Pluripotent Adult Somatic Stem Cells In Planarians, Norito Shibata, Labib Rouhana, Kiyokazu Agata

Biological Sciences Faculty Publications

Freshwater planarians, Plathelminthes, have been an intriguing model animal of regeneration studies for more than 100 years. Their robust regenerative ability is one of asexual reproductive capacity, in which complete animals develop from tiny body fragments within a week. Pluripotent adult somatic stem cells, called neoblasts, assure this regenerative ability. Neoblasts give rise to not only all types of somatic cells, but also germline cells. During the last decade, several experimental techniques for the analysis of planarian neoblasts at the molecular level, such as in situ hybridization, RNAi and fluorescence activated cell sorting, have been established. Moreover, information about genes …

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Patterned Cell Cultures For High Throughput Studies Of Cell Electrophysiology And Drug Screening Applications, Anupama Natarajan Jan 2010

Patterned Cell Cultures For High Throughput Studies Of Cell Electrophysiology And Drug Screening Applications, Anupama Natarajan

Electronic Theses and Dissertations

Over the last decade, the field of tissue and bio-engineering has seen an increase in the development of in vitro high-throughput hybrid systems that can be used to understand cell function and behavior at the cellular and tissue levels. These tools would have a wide array of applications including for implants, drug discovery, and toxicology, as well as for studying cell developmental behavior and as disease models. Currently, there are a limited number of efficient, functional drug screening assays in the pharmacology industry and studies of cell-surface interactions are complicated and invasive. Most cell physiology studies are performed using conventional …

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Tetanus In An Intensive Care Unit Of A Turkish Hospital: Patient Analysis Of A 6-Year Period, Behi̇ce Kurtaran, Emre Karakoç, Aslihan Candevi̇r, Süheyla Kömür, Ayşe Seza İnal, Fi̇li̇z Ki̇bar, Yeşi̇m Taşova, Neşe Saltoğlu, Hasan Sali̇h Zeki̇ Aksu Jan 2010

Tetanus In An Intensive Care Unit Of A Turkish Hospital: Patient Analysis Of A 6-Year Period, Behi̇ce Kurtaran, Emre Karakoç, Aslihan Candevi̇r, Süheyla Kömür, Ayşe Seza İnal, Fi̇li̇z Ki̇bar, Yeşi̇m Taşova, Neşe Saltoğlu, Hasan Sali̇h Zeki̇ Aksu

Turkish Journal of Medical Sciences

To retrospectively evaluate the clinical features of patients admitted to the medical intensive care unit (ICU) of our hospital between January 2001 and May 2007 due to tetanus. Materials and methods: Patient vaccination history, incubation period, nosocomial infections, noninfectious conditions, mortality, and length of stay in the ICU and hospital were documented. Results: Fifteen tetanus patients were admitted during the 6-year period. Mean age of the patients (9 male, 6 female) was 60 ± 13 years. Median length of stay was 42 days (range: 30-77 days) for survivors and 7 days (range: 1-59 days) for non-survivors. Mortality was consequent to …

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Histopathologic Changes In The Rabbit Submandibular Gland After 5-Fluorouracil Chemotherapy, Oktay Özel, Abdullah Ayçi̇çek, Fethullah Kenar, Fatma Aktepe, Ramazan Sargin, Mustafa Deni̇z Yilmaz, Fevzi̇ Sefa Dereköy Jan 2010

Histopathologic Changes In The Rabbit Submandibular Gland After 5-Fluorouracil Chemotherapy, Oktay Özel, Abdullah Ayçi̇çek, Fethullah Kenar, Fatma Aktepe, Ramazan Sargin, Mustafa Deni̇z Yilmaz, Fevzi̇ Sefa Dereköy

Turkish Journal of Medical Sciences

To determine the early-stage effects of 5-fluorouracil (5-FU) on the histology of the submandibular gland. Materials and methods: The study included 30 New Zealand rabbits. They were divided into 3 groups. No drugs were administered to group 1 (control group), and 5-FU was administered for 5 days to group 2 and for 10 days to group 3. Submandibular gland excision was then performed. Histopathological examination was performed with hematoxylin-eosin staining, apoptosis was determined based on TUNEL staining, and cell proliferation was examined using the PCNA antibody. Results: While no granular change was seen in group 1, granular change was observed …

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Effect Of Passive Smoking On The Development Of Chronic Obstructive Pulmonary Disease In Southeastern Turkey, Teki̇n Yildiz, Füsun Topçu, Yusuf Çeli̇k, Levent Akyildiz, Güngör Ateş, Di̇lek Durak Jan 2010

Effect Of Passive Smoking On The Development Of Chronic Obstructive Pulmonary Disease In Southeastern Turkey, Teki̇n Yildiz, Füsun Topçu, Yusuf Çeli̇k, Levent Akyildiz, Güngör Ateş, Di̇lek Durak

Turkish Journal of Medical Sciences

To determine the effect of passive smoking on the development of chronic obstructive pulmonary disease (COPD) among persons who spend a long time in cafes. Materials and methods: The study sample included 348 male smokers who were older than 40 years and spend a long time in cafes. The questions were derived from the European Coal and Steel Community (ECSC) questionnaire. We also inquired about the nature of cafe visits (hours/day, visits/week, visits/month). Results: COPD was found in 18.1% (63/348 subjects) of the smokers aged >=40 years. In these 63 subjects, based on spirometry results, the rate of mild and …

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The Nonpsychoactive Cannabinoid Cannabidiol Inhibits 5-Hydroxytryptamine3a Receptor-Mediated Currents In Xenopus Laevis Oocytes, Keun-Hang Susan Yang, Sehamuddin Galadari, Dmytro Isaev, Georg Petroianu, Toni S. Shippenberg, Murat Oz Jan 2010

The Nonpsychoactive Cannabinoid Cannabidiol Inhibits 5-Hydroxytryptamine3a Receptor-Mediated Currents In Xenopus Laevis Oocytes, Keun-Hang Susan Yang, Sehamuddin Galadari, Dmytro Isaev, Georg Petroianu, Toni S. Shippenberg, Murat Oz

Mathematics, Physics, and Computer Science Faculty Articles and Research

The effect of the plant-derived nonpsychotropic cannabinoid, cannabidiol (CBD), on the function of hydroxytryptamine (5-HT)3A receptors expressed in Xenopus laevis oocytes was investigated using two-electrode voltage-clamp techniques. CBD reversibly inhibited 5-HT (1 μM)-evoked currents in a concentration-dependent manner (IC50 = 0.6 μM). CBD (1 μM) did not alter specific binding of the 5-HT3A antagonist [3H]3-(5-methyl-1H-imidazol-4-yl)-1-(1-methylindol-3-yl)propan-1-one (GR65630), in oocytes expressing 5-HT3A receptors. In the presence of 1 μM CBD, the maximal 5-HT-induced currents were also inhibited. The EC50 values were 1.2 and 1.4 μM, in the absence and presence of CBD, indicating that CBD acts as a noncompetitive antagonist of 5-HT3 …

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Impact Of Static Stretch And Muscular Contractions On Force Production Within The Human Triceps Surae Muscle-Tendon Complex, Anthony D. Kay Jan 2010

Impact Of Static Stretch And Muscular Contractions On Force Production Within The Human Triceps Surae Muscle-Tendon Complex, Anthony D. Kay

Theses: Doctorates and Masters

Pre-performance routines commonly include stretching and intense muscular contractions in an attempt to optimise muscular performance and reduce injury risk. However, the isolated and combined effects of stretching and muscle contractions on neuromuscular performance are not well described. The aims of this research were to examine the effects of acute static stretch and intense muscular contractions on force production of the human plantarflexors and to examine possible mechanical and neuromuscular mechanisms underpinning any changes. Techniques including isokinetic dynamometry, electromyography (EMG), sonography and motion analysis were used in three studies on recreationally active human volunteers (n=20). In the first study, three …

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The Clinical And Polysomnographic Features In Complex Sleep Apnea Syndrome, Handan İnönü, Tansu Ulukavak Çi̇ftçi̇, Oğuz Köktürk Jan 2010

The Clinical And Polysomnographic Features In Complex Sleep Apnea Syndrome, Handan İnönü, Tansu Ulukavak Çi̇ftçi̇, Oğuz Köktürk

Turkish Journal of Medical Sciences

Complex sleep apnea syndrome (CompSAS) is characterized by the onset of central apneas or a Cheyne-Stokes breathing pattern in some patients with obstructive sleep apnea syndrome (OSAS) who were treated with continuous positive airway pressure (CPAP). The etiology of CompSAS is unclear, but derangement of respiratory control has been proposed. We sought to compare clinical and polysomnography (PSG) features of patients with CompSAS and OSAS. Materials and methods: Records of PSG were evaluated in a total of 270 patients, retrospectively. CPAP titration was prescribed in patients with an apnea-hypopnea index (AHI) of >=15. Patients who developed a central AHI of …

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