Digital Commons Network^™

Pathology Of Breast Carcinoma: Diagnostic, Prognostic, And Therapeutic Issues And Challenges, Rohit Bhargava, Sunati Sahoo, Nicole Nicosia Esposito, Beiyun Chen

Pathology and Cell Biology Faculty Publications

No abstract provided.

Ovarian Epithelial-Stromal Interactions: Role Of Interleukins 1 And 6, Kamisha T. Woolery, Patricia A. Kruk

Pathology and Cell Biology Faculty Publications

Ovarian epithelial cancer is the most lethal gynecologic malignancy. The high mortality is attributed to the fact that most cases typically present in late stage when ovarian cancer (OC) has already spread beyond the ovary. Ovarian epithelial cancer cells are shed into intraperitoneal ascites and easily disseminate throughout the peritoneal cavity with preferential metastasis to the omentum, peritoneum, and local organs. Understanding how ovarian epithelial cells interact with and modulate their microenvironment can provide insight into the molecular mechanism(s) involved with malignant transformation and progression which may eventually identify novel diagnostic, prognostic, and therapeutic targets. The objective of this paper …

Effects Of Xs® Energy Drink On Aerobic Exercise Capacity Of Athletes, Kevin M. Sheehan, Lynn K. Hartzler

Biological Sciences Faculty Publications

A small increase in performance is often the difference between winning and losing for athletes, and energy supplements are marketed to give them a competitive edge. One such supplement is XS® Energy Drink which contains B vitamins, caffeine, taurine, and an herbal adaptogen blend. XS® Energy Drink is primarily designed and marketed as an alertness stimulus; however, it is also marketed to athletes as a performance enhancing supplement. The hypothesis of this investigation was that the consumption of XS® Energy Drink before exercise would increase aerobic capacity (an increase in Vo2max) and time to fatigue, and would decrease time for …

The Mechanosensory Role Of Primary Cilia In Vascular Hypertension, Surya M. Nauli, Xingjian Jin, Beerend P. Hierck

Pharmacy Faculty Articles and Research

Local regulation of vascular tone plays an important role in cardiovascular control of blood pressure. Aside from chemical or hormonal regulations, this local homeostasis is highly regulated by fluid-shear stress. It was previously unclear how vascular endothelial cells were able to sense fluid-shear stress. The cellular functions of mechanosensory cilia within vascular system have emerged recently. In particular, hypertension is insidious and remains a continuous problem that evolves during the course of polycystic kidney disease (PKD). The basic and clinical perspectives on primary cilia are discussed with regard to the pathogenesis of hypertension in PKD.

Thiazolyl N-Benzyl-Substituted Acetamide Derivatives: Synthesis, Src Kinase Inhibitory And Anticancer Activities, Asal Fallah-Tafti, Alireza Foroumadi, Rakesh Tiwari, Amir Nasrolahi Shirazi, David G. Hangauer, Yahao Bu, Tahmineh Akbarzadeh, Keykavous Parang, Abbas Shafiee

Pharmacy Faculty Articles and Research

KX2-391 (KX-01/Kinex Pharmaceuticals), N-benzyl-2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)acetamide, is a highly selective Src substrate binding site inhibitor. To understand better the role of pyridine ring and N-benzylsubstitution in KX2-391 and establish the structure-activity relationship, a number of N-benzyl substituted (2-morpholinoethoxy)phenyl)thiazol-4-yl)acetamide derivatives containing thiazole instead of pyridine were synthesized and evaluated for Src kinase inhibitory activities. The unsubstituted N-benzyl derivative (8a) showed the inhibition of c-Src kinase with GI50 values of 1.34 μM and 2.30 M in NIH3T3/c-Src527F and SYF/c-Src527F cells, respectively. All the synthesized compounds were evaluated for inhibition of cell proliferation of human colon carcinoma (HT-29), breast carcinoma (BT-20), and leukemia (CCRF-CEM) cells. …

Altered Self-Assembly And Apatite Binding Of Amelogenin Induced By N-Terminal Proline Mutation, Li Zhu, Vuk Uskoković, Thuan Le, Pamela Denbesten, Yulei Huang, Stefan Habelitz, Wu Li

Pharmacy Faculty Articles and Research

Objective—A single Pro-70 to Thr (p.P70T) mutation of amelogenin is known to result in hypomineralized amelogenesis imperfecta (AI). This study aims to test the hypothesis that the given mutation affects the self-assembly of amelogenin molecules and impairs their ability to conduct the growth of apatite crystals.

Design—Recombinant human full-length wild-type (rh174) and p.P70T mutated amelogenins were analyzed using dynamic light scattering (DLS), protein quantification assay and atomic force microscopy (AFM) before and after the binding of amelogenins to hydroxyapatite crystals. The crystal growth modulated by both amelogenins in a dynamic titration system was observed using AFM.

Results—As …

Determining The Functional Role Of Trem-Like Transcript 2 In The Innate Immune Response, Matthew Martin Halpert

All ETDs from UAB

TLT2 is one of four receptors conserved between mouse and human within the TREM locus, and is expressed on B cells, macrophages, and neutrophils. TLT2 ligation on murine macrophages induces the production of chemokines and growth factors, as evidenced by ex vivo treatment with anti-TLT2 mAbs. This treatment did not lead to the upregulation of activation markers such as CD69 or costimulatory molecules such as CD80 and CD86, indicating a specific response following TLT2 ligation. This is recapitulated in vivo following injection of anti-TLT2 mAbs resulting in the production of chemokines and growth factors, which ultimately lead to enhanced neutrophil …

Polyethylenimine-Conjugated Gold Nanoparticles: Gene Transfer Potential And Low Toxicity In The Cornea, Ajay Sharma, Ashish Tandon, Jonathan C. K. Tovey, Rangan Gupta, J. David Robertson, Jennifer A. Fortune, Alexander M. Klibanov, John W. Cowden, Frank G. Rieger, Rajiv R. Mohan

Pharmacy Faculty Articles and Research

This study examined the gene transfer efficiency and toxicity of 2-kDa polyethylenimine conjugated to gold nanoparticles (PEI2-GNP) in the human cornea in vitro and rabbit cornea in vivo. PEI2-GNP with nitrogen-to-phosphorus (N/P) ratios of up to 180 exhibited significant transgene delivery in the human cornea without altering the viability or phenotype of these cells. Similarly, PEI2-GNP applied to corneal tissues collected after 12 h, 72 h, or 7 days exhibited appreciable gold uptake throughout the rabbit stroma with gradual clearance of GNP over time. Transmission electron microscopy detected GNP in the keratocytes and the extracellular matrix of the rabbit corneas. …

Roles Of The 15-Kda Selenoprotein (Sep15) In Redox Homeostasis And Cataract Development Revealed By The Analysis Of Sep 15 Knockout Mice, Marina V. Kasaikina, Dmitri E. Fomenko, Vyacheslav M. Labunskyy, Salil A. Lachke, Wenya Qiu, Juliet A. Moncaster, Jie Zhang, Mark W. Wojnarowicz, Sathish Kumar Natarajan, Mikalai I. Malinouski, Ulrich Schweizer, Petra A. Tsuji, Bradley A. Carlson, Richard L. Maas, Marjorie F. Lou, Lee E. Goldstein, Dolph L. Hatfield, Vadim N. Gladyshev

School of Veterinary and Biomedical Sciences: Faculty Publications

The 15-kDa selenoprotein (Sep15) is a thioredoxin-like, endoplasmic reticulum-resident protein involved in the quality control of glycoprotein folding through its interaction with UDP-glucose:glycoprotein glucosyltransferase. Expression of Sep15 is regulated by dietary selenium and the unfolded protein response, but its specific function is not known. In this study, we developed and characterized Sep15 KO mice by targeted removal of exon 2 of the Sep15 gene coding for the cysteinerich UDP-glucose:glycoprotein glucosyltransferase-binding domain. These KO mice synthesized a mutant mRNA, but the shortened protein product could be detected neither in tissues nor in Sep15 KO embryonic fibroblasts. Sep15 KO mice were viable …

Associatioin Of Plasma Aβ Peptides With Blood Pressure In The Elderly, Jean-Charles Lambert, Jean Dallongeville, Kathryn A. Ellis, Susanna Schraen-Maschke, James Lui, Simon Laws, Julie Dumont, Florence Richard, Dominque Cottel, Claudine Berr, David Ames, Colin L. Masters, Christopher C. Rowe, Cassandra Szoeke, Christophe Tzourio, Jean-Francois Dartigues, Luc Buee, Ralph Martins, Philippe Amouyel

Research outputs 2011

Background Aß peptides are often considered as catabolic by-products of the amyloid ß protein precursor (APP), with unknown physiological functions. However, several biological properties have been tentatively attributed to these peptides, including a role in vasomotion. We assess whether plasma Aß peptide levels might be associated with systolic and diastolic blood pressure values (SBP and DBP, respectively). Methodology/Principal Findings Plasma Aß1-40 and Aß1-42 levels were measured using an xMAP-based assay in 1,972 individuals (none of whom were taking antihypertensive drugs) from 3 independent studies: the French population-based 3C and MONA-LISA (Lille) studies (n = 627 and n = 769, respectively) …

Role Of Angiotensin Converting Enzyme 2 (Ace2) In Obesity-Associated Hypertension, Manisha Gupte

University of Kentucky Doctoral Dissertations

The purpose of this research was to determine whether adipocytes express ACE2 and its role in obesity-associated hypertension with diet-induced obesity.

To determine if ACE2 was expressed in adipose tissue and its regulation in the setting of diet-induced obesity, we fed male mice either a low fat (LF) or high fat (HF) diet acutely (1 week) or chronically ( 4 months). We demonstrated that ACE2 was regulated specifically in adipose tissue with consumption of a HF diet. However, with chronic HF feeding adipose ACE2 was dysregulated resulting in activation of the systemic RAS and increased blood pressure.

To determine the …

A Computational Framework For Proteome-Wide Pursuit And Prediction Of Metalloproteins Using Icp-Ms And Ms/Ms Data, W. Andrew Lancaster, Jeremy L. Praissman, Farris L. Poole, Aleksandar Cvetkovic, Angeli Lal Menon, Joseph W. Scott, Francis E. Jenney, Michael P. Thorgersen, Ewa Kalisiak, Junefredo V. Apon, Sunia A. Trauger, Gary Siuzdak, John A. Tainer, Michael W. W. Adams

PCOM Scholarly Works

BACKGROUND: Metal-containing proteins comprise a diverse and sizable category within the proteomes of organisms, ranging from proteins that use metals to catalyze reactions to proteins in which metals play key structural roles. Unfortunately, reliably predicting that a protein will contain a specific metal from its amino acid sequence is not currently possible. We recently developed a generally-applicable experimental technique for finding metalloproteins on a genome-wide scale. Applying this metal-directed protein purification approach (ICP-MS and MS/MS based) to the prototypical microbe Pyrococcus furiosus conclusively demonstrated the extent and diversity of the uncharacterized portion of microbial metalloproteomes since a majority of the …

Molecular Piracy In The Mobilization Of Staphylococcus Aureus Pathogenicity Island 1, Michael Spilman

All ETDs from UAB

Staphylococcus aureus bacteriophage 80α is a temperate, double-stranded DNA phage that serves as a "helper" phage for the mobilization of several S. aureus pathogenicity islands (SaPIs), including SaPI1. When mobilized by 80α, SaPI1 genomes are packaged into smaller phage-like transducing particles composed of 80α capsid (gp47), scaffolding (gp46) and portal (gp42) proteins. In this dissertation, I utilize electron microscopy and biochemistry to tease apart the structural and genetic controls and consequences of SaPI1 as a molecular pirate. More specifically, I show that two SaPI1 proteins shift assembly from 63-nm, T = 7 icosahedral capsids to 47-nm, T = 4 capsids, …

Plasma Adiponectin And Resistin Levels In Women With Polycystic Ovary Syndrome: Relation To Body Mass Index And Insulin Resistance, Emre Di̇kmen, İlhan Tarkun, Funda Öztürk, Berri̇n Arslan, Zeynep Cantürk

Turkish Journal of Medical Sciences

To compare the serum levels of adiponectin and resistin between patients with polycystic ovary syndrome (PCOS) and healthy control subjects matched for age and body mass index (BMI), and to assess possible correlations of adiponectin and resistin to the hormonal and metabolic parameters of the syndrome. Materials and methods: Fifty five patients with PCOS diagnosis composed of 25 obese, 13 overweight, 17 normal weight subjects, and 49 healthy women matched for age and BMI were included in this study. Hormone and lipid profile, adiponectin, and resistin were measured in all cases. Results: Serum adiponectin levels were similar in the lean …

The Short Term Effect Of The Law Prohibiting Smoking In Enclosed Areas Upon The Smoking Conditions Of Employees In Kayseri, Turkey, Ahmet Öztürk, Serpi̇l Poyrazoğlu, Şule Şarli

Turkish Journal of Medical Sciences

A law prohibiting smoking in the enclosed areas of public and private workplaces was put into effect in Turkey on 19 May 2008. The objective of this study was to evaluate the effect of this law upon the smoking habits of the employees in this short period of 3 months. Materials and methods: This study was performed in Kayseri, in 3 public and 3 private workplaces, comprising 868 employees. A questionnaire was filled out, face-to-face, in the second week of August. Results: The ratio of the people supporting this smoke-free law was 68.7%. Among the employees who were smoking when …

Şerefeddin Sabuncuoğlu’S Drawings Of Gyneco-Obstetric Instruments, Nuri̇ Seli̇m Kadioğlu, Oya Ögenler, İlter Uzel

Turkish Journal of Medical Sciences

The purpose of our study was to determine the contribution of Şerefeddin Sabuncuoğlu's achievement to bring gynecology to the modern knowledge level. The gynecological tools in the achievement of Serefeddin Sabuncuoğlu, who is the late period representative of classical medical paradigm, are examined in connection with the achievement of Zahravi, which belongs to the classical medical literature. It was determined that in the long time interval from Zahravi to Sabuncuoğlu a limited advancement occurred in medical knowledge, and that the differences between the achievements of the 2 doctors are important for reflecting the development between the 2 periods.

Hypolipidemic And Antioxidant Activity Of Aqueous Extract Of Monascus Purpureus Fermented Indian Rice In High Cholesterol Diet Fed Rats, Aiyalu Rajasekaran, Muthusamy Kalaivani

Turkish Journal of Medical Sciences

To evaluate hypolipidemic and anti-oxidant activities of Monascus purpureus fermented Indian variety of rice. Materials and methods: Indian rice variety IR-532-E-576 was fermented with Monascus purpureus MTCC 1090 (Monascaceae) and extracted with water by boiling. Experimentally induced hyperlipidemia was produced by feeding rats with 2% cholesterol enriched diet for 15 days. Afterwards hypercholesterolemic rats were orally administered with Monascus fermented Indian rice extract at the dose of 1.2 and 2.4 mg/kg bw along with high cholesterol diet for 30 successive days in order to evaluate their expected hypolipidemic activity. Plasma lipid parameters such as total cholesterol, triglycerides, LDL (low density …

Which Predicts The Cardiovascular Risk Best In Elderly Metabolic Syndrome Patients: Atp Iii Or Idf?, Serpi̇l Aydin, Ayfer Gemalmaz, Tufan Nayi̇r, Şule Özkan

Turkish Journal of Medical Sciences

As metabolic syndrome (MetS) is one of the major determinants of cardiovascular disease, it is important to detect and intervene with MetS in order to minimize cardiovascular risk. The objectives of this study were to identify the prevalence of MetS in our elderly patients and to evaluate the ability IDF and ATP III to predict the cardiovascular risk. Materials and methods: This cross-sectional study included patients above 65 years attending the outpatient clinic of a hospital over a 4-year period and who gave oral informed consent for participation in the study. ATP III and IDF criteria were compared according to …

Invasive Device-Associated Nosocomial Infections Of A Teaching Hospital In Turkey; Four Years’ Experience, Aslihan Candevi̇r, Behi̇ce Kurtaran, Fi̇li̇z Ki̇bar, Emre Karakoç, Hasan Sali̇h Zeki̇ Aksu, Yeşi̇m Taşova

Turkish Journal of Medical Sciences

To determine our setting's IDAI rates, infecting microorganisms, and their resistance patterns to achieve standardization and make comparisons among other Turkish and developed country hospitals all over the world. Materials and methods: The numbers of total patient days, ventilator days, central catheter days and, urinary catheter days in the ICUs were recorded and IDAI rates were calculated. Clinical specimens were obtained from patients, cultivated at appropriate culture media, and infecting microorganisms and resistance patterns were determined. Results: Totally 1450 invasive device-associated infection episodes were determined (16.4% of patients) with a rate of 21.12/1000 days. Ventilator associated pneumonia rate was 22.05/1000 …

Management Of Community-Acquired Acute Bacterial Cystitis In Turkey, Ömer Coşkun, Hakan Erdem, Ali̇ Avci

Turkish Journal of Medical Sciences

Community acquired acute bacterial cystitis (CA-ABC) is one of the most common infectious presentations in the community. This paper aims to provide a rational approach in the management of CA-ABC based on local Turkish data. Materials and methods: The publications evaluating the microbiological data obtained from CA-ABC cases were searched in both Turkish and international databases. Results: Fosfomycin and nitrofurantain appear to be baseline antibiotics while the empirical use of trimethoprim sulfamethoxazole, amoxicillin clavulanate, and first and second generation cephalosporins seems to be unreliable in Turkey. Moreover, quinolones seem to be at the edge with resistance rates up to 20%. …

In Vitro Effects Of Some Drugs On Human Erythrocyte Glutathione Reductase, Ebru Akkemi̇k, Murat Şentürk, Fatma Betül Özgeri̇ş, Pinar Taşer, Mehmet Çi̇ftci̇

Turkish Journal of Medical Sciences

The effects of dacarbazine, thiocolchicoside, methotrexate, olanzapine, pantoprazole sodium, and 5-fluorouracil on the enzyme activity of glutathione reductase (GR) were studied using human erythrocyte GR enzymes in in vitro studies, respectively. Materials and methods: The enzyme was purified 3333-fold from human erythrocytes in a yield of 44.44% with 4.0 U/mg. The purification procedure involved the preparation of hemolysate, ammonium sulfate precipitation, 2', 5'-ADP Sepharose 4B affinity chromatography, and Sephadex G-200 gel filtration chromatography. SDS-PAGE showed a single band for enzyme. Purified enzyme was used in the in vitro studies. Results: In the in vitro studies, IC50 values and Ki constants …

Immunomodulatory Role Of Leptin Treatment In Experimental Sepsis Caused By Gram Negative Bacteria, Cemi̇le Koca, Havva Şahi̇n Kavakli, Özlem Alici

Turkish Journal of Medical Sciences

To investigate the effect of leptin treatment on circulating inflammatory cytokines and on tissue damage in experimental rat model of gram-negative sepsis. Materials and methods: Adult male Wistar rats, 28 in total, were randomly divided into 4 groups (n = 7): sham, leptin, sepsis, and sepsis group treated with leptin (sepsis+leptin). Sepsis was induced by intraperitoneal (ip) injection of 2 × 10^{10} CFU of Escherichia coli ATCC 25922. Leptin and sepsis+leptin groups received a single dose ip 0.1 mg/kg leptin, while sham group received 1 mL of ip saline. Rats were sacrificed 24 h after the induction of sepsis. Blood …

Obesity In Children And Adolescents And Its Relationship With Hypertension, Dr Vijayanath Itagi, Ramesh Patil

Turkish Journal of Medical Sciences

It is difficult to project the prevalence of obesity and overweight among children in India since there is no nationally representative data from India. We determined the time trends in childhood obesity in a representative sample of schoolchildren from Raichur District, Karnataka and investigated the relationship of obesity with blood pressure. Materials and methods: We used a stratified random cluster sampling method to select the children. Anthropometric data were collected from 23,842 students, 5-16 years of age, during 2005-06. Blood pressure and anthropometric data were collected from 19,263 students during 2007-08. Overweight and obesity were defined by body mass index …

Dimensions Of Water Contamination In The Subprovinces Of Adana Province, Turkey, Ferdi̇ Tanir, Beri̇l Akçi̇men, Fati̇h Köksal, Necdet Aytaç, İbrahi̇m Cengi̇zler

Turkish Journal of Medical Sciences

To determine the dimension of the contamination of the drinking and utility water in the touristic Bahçe district of the Karataş subprovince of Adana province, and to share our views on how to raise the quality of the water in the district. Materials and methods: In 2007 and 2008, 80 samples were taken 8 times, on a seasonal basis, from the drinking water and sea water of the Bahçe district. Eleven organic and inorganic parameters were measured and presented following a comparison with criteria values Results: Ni, Zn, Cu, Pb, NO3-N, COD, and phenol contamination parameters were found to be …

Serum Osteoprotegerin (Opg) Measurement In Behçet's Disease, Nafi̇ye Fulya İlhan, Nesri̇n Demi̇r, Tamer Demi̇r, Ahmet Gödekmerdan

Turkish Journal of Medical Sciences

Recent studies indicate that osteoprotegerin (OPG) acts as an important molecule in the development of vascular diseases. The aim of the present study was to examine the association between serum OPG levels and Behcet's disease (BD). Materials and methods: Twenty-five patients with BD and 20 healthy control subjects, matched for age and sex, were included in this study. Serum levels of OPG were determined using ELISA. Results: We found that serum levels of OPG were significantly higher in patients with BD than in healthy control subjects (813.75 ± 11 vs. 655.56 ± 17 pg/mL, P = 0.002). There was no …

Metabolic Profile And Insulin Resistance In Patients With Obstructive Sleep Apnea Syndrome, Mustafa Şahi̇n, Berri̇n Berçi̇k İnal, Şahi̇n Öğreden, Özgür Yi̇ği̇t, Hale Aral, Güvenç Güvenen

Turkish Journal of Medical Sciences

The following metabolic parameters were assessed in patients with obstructive sleep apnea syndrome (OSAS) diagnosed by polysomnography (PSG): leptin, IFG (ımpaired fasting glucose), thyroid functions, thyroid autoantibodies, lipid parameters, insulin levels, HOMA-IR index, CRP, obesity, and metabolic syndrome frequency. Materials and methods: Three patient groups were defined based on apnea-hypoapnea index (AHI) levels (Group I: n: 11 male (M)/19 female (F); Group II: n: 19 M/10 F; Group III: n: 21 M/10 F) and 2 control groups (obese (n = 18 M/12 F) and normal (n = 12 M/18 F)) were included with comparable BMI value and age. Results: The …

Aids Knowledge And Risky Sexual Behaviors Among Registered Female Sex Workers In Turkey, Tüli̇n Bedük, Hayri̇ye Ünlü, Veli̇ Duyan

Turkish Journal of Medical Sciences

To evaluate AIDS knowledge and risky sexual behaviors of registered female sex workers during their obligatory periodic examination in the Department of Dermatology and Sexually Transmitted Diseases, Ankara Metropolitan Municipality Hospital. Materials and methods: A questionnaire composed of items on socio-demographic features and knowledge levels on HIV/AIDS, its transmission routes, and risky sexual behaviors was administered via face to face interviews. Results: One hundred four sex workers were included in the study. Higher educated ones had more knowledge on AIDS, its transmission routes, and risky behaviors (P >= 0.05, P Keywords: Commercial sex workers, HIV/AIDS transmission, risky sexual behavior

A Pooled Analysis Of The Resistance Patterns Of Escherichia Coli Strains Isolated From Urine Cultures In Turkey: A Comparison Of The Periods 1997-2001 And 2002-2007, Meltem Işikgöz Taşbakan, Hüsnü Pullukçu, Oğuz Reşat Si̇pahi̇, Tansu Yamazhan, Bi̇lgi̇n Arda, Sercan Ulusoy

Turkish Journal of Medical Sciences

To compare the resistance patterns of Escherichia coli strains reported to be isolated from urine cultures in published medical literature from Turkey in 1997-2001 and 2002-September 2007. Materials and methods: To find the published series, 3 national databases (Ulakbim Turkish Medical Literature database, http://www.turkishmedline.com, http://medline.pleksus.com.tr), and 2 international databases (Pubmed and Science Citation Index (SCI)) were searched. Results: Data for 25,577 E. coli strains were obtained from 53 articles (28 articles from 1997-2001, 25 from 2002-2007). Of these strains 18,106 were isolated from outpatients, whereas 7471 were from inpatients. When the strains isolated from outpatients were evaluated, there was a …

Retrospective Evaluation Of Laboratory-Confirmed And Recovered Cases Of Influenza A(H1n1)V, Funda Sevencan, Mehmet Meli̇kşah Ertem, Neval Özçullu, Vedat Dorman, Abdulvahi̇t Ormanli, Namik Kemal Kubat, Nurhan Albayrak, Ayşe Başak Altaş

Turkish Journal of Medical Sciences

To retrospectively evaluate patients that were diagnosed with H1N1 and recovered from the disease in the initial period of an influenza A(H1N1)v epidemic in the province of Diyarbakir. It is estimated that 34-67 million individuals around the world have been infected by influenza A(H1N1)v, that 154,000-303,000 individuals have been hospitalized, and that 7000-13,000 individuals have lost their lives. Materials and methods: We were able to include 250 of 362 cases (69.0%) of confirmed influenza A(H1N1)v, from which the patients recovered, from the samples received between 19 October and 3 December 2009 after a pandemic alarm was given in the province …

Surveillance Of Antimicrobial Use In A Turkish University Hospital, Rabi̇n Saba, Di̇lara İnan, Özge Turhan, Ata Nevzat Yalçin, Fi̇li̇z Günseren, Lati̇fe Mamikoğlu

Turkish Journal of Medical Sciences

To determine antimicrobial use in a university hospital in Turkey and compare it with United States antimicrobial use and resistance (US-AUR) and International Nosocomial Infection Control Consortium (INICC) rates. Materials and methods: This was a prospective surveillance study done between January 2007 and December 2007. The data are standardized by use of the defined daily dose (DDD) for each antimicrobial group and by calculating use per 1000 patients (antibiotic use density-AD). Results: Data on 35,936 patients with a total of 215,616 patient-days were analyzed. Ampicillin group (mainly with a beta lactamase inhibitor) has the highest AD in ICU and non-ICU …