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South Carolina Statewide Science Safety Project., Linda Sinclair, Jack Gerlovich, Rahul A. Parsa

Journal of the South Carolina Academy of Science

No abstract provided.

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Some Notes On Multiplicative Congruential Random Number Generators With Mersenne Prime Modulus 261-1., James Harris

Journal of the South Carolina Academy of Science

No abstract provided.

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Maternal And Sibling Influences On Seed Germination Of Aegilops Triuncialis Erin, Erin Scott, Andrew R. Dyer

Journal of the South Carolina Academy of Science

No abstract provided.

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Scas Officers And Council Members 2003 - 2004

Journal of the South Carolina Academy of Science

No abstract provided.

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Critical Thinking And Biology Instruction., David J. Stroup, John L. Frola

Journal of the South Carolina Academy of Science

No abstract provided.

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Peritoneal Defense Mechanisms, Toni̇ Hau

Turkish Journal of Medical Sciences

No abstract provided.

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Drug Resistance In Acute Leukaemia And Reversion, Jean-Pierre Marie, Ollivier Legrand

Turkish Journal of Medical Sciences

No abstract provided.

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Bioavailability Of The Tea Flavonoids Epicatechin And Epicatechin Gallate: Role Of Membrane Transport And Metabolism, Jaya Bharathi Vaidyanathan

MUSC Theses and Dissertations

Tea flavonoids, including (-)-epicatechin (EC), (-)-epicatechin gallate (ECG), (-)-epigallocatechin gallate (EGCG) and (-)-epigallocatechin (EGC) have been shown to have chemopreventive activity in cancer. Studies in animals and humans suggest that these dietary compounds have a very low oral bioavailability. However, the reason behind this limited bioavailability as well as the mechanisms underlying absorption is not clearly understood. The overall hypothesis of this dissertation project is that the human intestinal absorption of (-)-epicatechin (EC) and its gallate, (-)epicatechin- 3-gallate (ECG) is limited and regulated both by multiple transport mechanisms and metabolism. We used the Caco-2 cell monolayers, a well-established model to …

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A Contrast-Based Neural Control System For Ant Navigation, Joanna R. Wares, Predrag-Peter Ilich, Daniel P. Dougherty

Department of Math & Statistics Faculty Publications

A mathematical model for a neural control system of ant locomotion was developed. Contrast-based detectors using excitation and inhibition were tuned to specific contrast orientations. A control system using multiple orientation contrast detectors was then developed and optimized for a model ant, which could move via a biased random walk. The system allowed sufficient control to guide the ant through various mazes.

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Nucleotide Excision Repair- And Polymerase Eta-Mediated Error-Prone Removal Of Mitomycin C Interstrand Cross-Links, H. Zheng, X. Wang, A. J. Warren, R. J. Legerski, Rodney S. Nairn, Joshua W. Hamilton, Lei Li

Dartmouth Scholarship

Interstrand cross-links (ICLs) make up a unique class of DNA lesions in which both strands of the double helix are covalently joined, precluding strand opening during replication and transcription. The repair of DNA ICLs has become a focus of study since ICLs are recognized as the main cytotoxic lesion inflicted by an array of alkylating compounds used in cancer treatment. As is the case for double-strand breaks, a damage-free homologous copy is essential for the removal of ICLs in an error-free manner. However, recombination-independent mechanisms may exist to remove ICLs in an error-prone fashion. We have developed an in vivo …

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Genetic Health And Eugenics Precedents: A Voice Of Caution, Larry I. Palmer

Faculty Publications

No abstract provided.

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Animal Anti-Apoptotic Genes Ameliorate The Loss Of Turgor In Water-Stressed Transgenic Tobacco, Tala Awada, D. D. Dunigan, M. B. Dickman

Nebraska Center for Virology: Faculty Publications

Nicotiana tabacum L. ‘Glurk’ plants were transformed with antiapoptotic animal genes [chicken Bcl-xl; nematode CED-9; chicken Bcl-xl(GA) a mutant of Bcl-xl; and a 3’ non-coding region of human Bcl-2, referred to as 161-1]. Our objectives were to determine whether plant transformation with anti-apoptotic genes ameliorates drought tolerance in tobacco plants by subjecting the plants to a dry-down period. The non-transformed Glurk and the transgenic Glurk harboring G115, which expresses β-glucuronidase, served as controls. Transformation of tobacco plants with animal anti-apoptotic genes significantly impacted the rates of photosynthesis (A) and stomatal conductance (g_s), but not to the same extent …

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Identification Of Novel Domains Within Sox-2 And Sox-11 Involved In Autoinhibition Of Dna Binding And Partnership Specificity, Matthew S. Wiebe, Tamara K. Nowling, Angie Rizzino

Nebraska Center for Virology: Faculty Publications

Sox transcription factors play key regulatory roles throughout development, binding DNA through a consensus (A/T)(A/T)CAA(A/T)G sequence. Although many different Sox proteins bind to this se-quence, it has been observed that gene regulatory elements are commonly responsive to only a small subset of the entire family, implying that regulatory mechanisms exist to permit selective DNA bind-ing and/or transactivation by Sox family members. To identify and explore the mechanisms modu-lating gene activation by Sox proteins further, we compared the function of Sox-2 and Sox-11. This led to the discovery that Sox proteins are regulated differentially at multiple levels, including trans-activation, protein partnerships …

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Osmosensitive Taurine Release: Does Taurine Share The Same Efflux Pathway With Chloride And Other Amino Acid Osmolytes?, Rodrigo Franco

School of Veterinary and Biomedical Sciences: Faculty Publications

Swelling subsequent to hyposmotic conditions activates a process of volume regulation present in most cell types. This volume adjustment is accomplished by osmolyte translocation toward the extracellular space to reach a new osmotic equilibrium. Molecules involved in this homeostatic mechanism have been broadly classified into two categories: organic and inorganic osmolytes. Inorganic osmolytes comprise mainly the intracellular ions K⁺ and Cl^–. Cell swelling–induced activation of separate K⁺ and Cl^– channels has been described in most preparations. Organic osmolytes are grouped in three categories: amino acids, polyalcohols, and methylamines. These osmolytes, particularly taurine, are present in …

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Role Of Activator Protein-1 In The Down-Regulation Of The Human Cyp2j2 Gene In Hypoxia, Nicole Y. Marden, Eva Fiala-Beer, Shi-Hua Xiang, Michael Murray

School of Veterinary and Biomedical Sciences: Faculty Publications

The cytochrome P450 (CYP) 2J2 arachidonic acid epoxygenase gene was down-regulated at a pre-translational level in human hepatoma-derived HepG2 cells incubated in a hypoxic environment; under these conditions, the expression of c-Jun and c-Fos mRNA and protein was increased. The 5′-upstream region of the CYP2J2 gene was isolated by amplification of a 2341 bp fragment and putative regulatory elements that resembled activator protein-1 (AP-1)-like sequences were identified. From transient transfection analysis, c-Jun was found to strongly activate a CYP2J2–luciferase reporter construct, but co-transfection with plasmids encoding c-Fos or c-Fos-related antigens, Fra-1 and -2, abrogated reporter activity. Using a series …

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Mucosal Priming Of Simian Immunodeficiency Virus-Specific Cytotoxic T-Lymphocyte Responses In Rhesus Macaques By The Salmonella Type Iii Secretion Antigen Delivery System, David T. Evans, Li-Mei Chen, Jacqueline Gillis, Kuei-Chin Lin, Brian Harty, Gail P. Mazzara, Ruben O. Donis, Keith G. Mansfield, Jeffrey D. Lifson, Ronald C. Desrosiers, Jorge E. Galán, R. Paul Johnson

School of Veterinary and Biomedical Sciences: Faculty Publications

Nearly all human immunodeficiency virus (HIV) infections are acquired mucosally, and the gut-associated lymphoid tissues are important sites for early virus replication. Thus, vaccine strategies designed to prime virus-specific cytotoxic T lymphocyte (CTL) responses that home to mucosal compartments may be particularly effective at preventing or containing HIV infection. The Salmonella type III secretion system has been shown to be an effective approach for stimulating mucosal CTL responses in mice. We therefore tested ∆phoP-phoQ attenuated strains of Salmonella enterica serovar Typhimurium and S. enterica serovar Typhi expressing fragments of the simian immunodeficiency virus (SIV) Gag protein fused to the …

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Method To Detect The Presence Of A Microorganism Or Agent In An Animal, David R. Smith, Laura L. Hungerford, Rodney A. Moxley, Susanne Hinkley, Terry Klopfenstein, Jeff Gray

School of Veterinary and Biomedical Sciences: Faculty Publications

The present invention provides a method to detect the presence of a microorganism or agent in an animal. The method encompasses placement of devices at various locations where the animal resides so as to induce the animal to initiate contact with the device. As a result of this contact, the animal deposits various microorganisms and agents on the device. The device is then tested for the presence of the particular microorganism or agent of interest.

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Myosin Heavy Chain And Physiological Adaptation Of The Rat Diaphragm In Elastase-Induced Emphysema., Dong Kwan Kim, Jianliang Zhu, Benjamin W Kozyak, James M Burkman, Neal A Rubinstein, Edward B Lankford, Hansell H Stedman, Taitan Nguyen, Sanford Levine, Joseph B Shrager

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

BACKGROUND: Several physiological adaptations occur in the respiratory muscles in rodent models of elastase-induced emphysema. Although the contractile properties of the diaphragm are altered in a way that suggests expression of slower isoforms of myosin heavy chain (MHC), it has been difficult to demonstrate a shift in MHCs in an animal model that corresponds to the shift toward slower MHCs seen in human emphysema. METHODS: We sought to identify MHC and corresponding physiological changes in the diaphragms of rats with elastase-induced emphysema. Nine rats with emphysema and 11 control rats were studied 10 months after instillation with elastase. MHC isoform …

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Faculty Publications 2002, Lsu Health Sciences Center New Orleans

Historical Faculty Publications

This Faculty bibliography contains 876 publications.

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Saru, A Sara Homolog, Is Repressed By Sart And Regulates Virulence Genes In Staphylococcus Aureus, Adhar C. Manna, Ambrose L. Cheung

Dartmouth Scholarship

In searching the Staphylococcus aureus genome, we previously identified sarT, a homolog of sarA, which encodes a repressor for alpha-hemolysin synthesis. Adjacent but transcribed divergently to sarT is sarU, which encodes a 247-residue polypeptide, almost twice the length of SarA. Sequence alignment disclosed that SarU, like SarS, which is another SarA homolog, could be envisioned as a molecule with two halves, with each half being homologous to SarA. SarU, as a member of the SarA family proteins, disclosed conservation of basic residues within the helix-turn-helix motif and within the beta hairpin loop, two putative DNA binding domains within this protein …

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Vitamin D Dependent Down Regulation Of Arf1 Gene In Human Leukemia Cell Line Hl-60, Hakan Savli

Turkish Journal of Medical Sciences

VLI Department of Medical Biology, Faculty of Medicine, Kocaeli University, Kocaeli - Turkey

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Dose-Response Effects Of Lithium On Spatial Memory In The Black Molly Fish., Thomas Kyle Creson

Electronic Theses and Dissertations

Lithium continues to be widely prescribed for the management of bipolar disease, yet cognitive impairment-related side effects promote noncompliance of the treatment regimen. We have introduced a novel animal model, the black molly fish, to study dose-response effects of lithium on short-term (STM) and long-term (LTM) memories. We developed a method utilizing capillary ion analysis (CIA), to measure plasma and brain lithium levels employed in our behavioral studies. We then developed an appropriate testing environment to ascertain learning capacities of these fish. We established that black mollies could adequately perform a forced-choice spontaneous alternation (SA) task used extensively in rodents …

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Activation Of Ca2+-Activated K+ Channels And Cell Migration By Hepatocyte Growth Factor/Scatter Factor In Madin-Darby Canine Kidney Cells., Min Jin

Electronic Theses and Dissertations

Hepatocyte Growth Factor/Scatter Factor (HGF/SF) stimulates migration of various cells and has been linked via Met tyrosine kinase signaling to transformation and the metastatic phenotype. HGF/SF-Met signaling also plays a role in malignancy. Migration of transformed MDCK-F cells depends on activation of a charybdotoxin (ChTX)-sensitive, volume-activated membrane K⁺ current. Patch-clamp electrophysiology and transwell migration assays were used to study the effects of HGF/SF on membrane K⁺ currents and cell migration in MDCK II cells. HGF/SF activated membrane K⁺ currents that increased over 24 hr, and these could be modulated by altering intracellular free calcium concentration [Ca^{2+ …}

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Mentha (Lamiaceae) Phylogenetic Analysis Using Chloroplast Trnl-Trnf And Nuclear Ribosomal Dna Its Sequences, Jiranan Bunsawatt

Masters Theses & Specialist Projects

Mentha (Nepetoideae, Lamiaceae) is a taxonomically complex genus that includes economically important members such as spearmint and peppermint and species of global conservation interest. Mentha is considered challenging systematically due to its high incidence of polyploidy, diverse morphology, variation in base chromosome number, and frequent interspecific hybridization. Our objectives were to test the monophyly of Mentha and each of its traditionally recognized sections, assess phylogenetic relationships of the Mentha species, test hypotheses of hybridization for the putative stabilized allopolyploids (M spicata and M. canadensis), and determine the ancestral base chromosome number using DNA sequence data from the chloroplast trnL-trnF and …

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Review Of "The Human Embryonic Stem Cell Debate: Science, Ethics, And Public Policy (Basic Bioethics)," Edited By Suzanne Holland, Karen Lebacqz, And Laurie Zoloth, James Steele

The University of New Hampshire Law Review

[Excerpt] "Perhaps like others, I started "The Human Embryonic Stem Cell Debate" not knowing many of the finer points of embryonic stem cell research, but I certainly had an opinion. This issue is far more complex than I had initially imagined. The editors do a commendable effort of compiling a sample of the innumerable arguments surrounding the debate."

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A New Immunoassay For Quantification Of A Novel Cancer Antigen In Serum And Immunostaining Of Carcinoma Tissues And Cultured Cells Revealing The Antigenic Cellular Location., Emily Christine Mcduffee

Electronic Theses and Dissertations

The purpose of this study is 1) to examine the presence of the antigen in serum by employing a newly developed ELISA immunoassay that quantifies the total antigen and bound antigen (antigen-antibody complex) using polyclonal chicken antibodies directed against an IgM-binding epitope of the new antigen, and 2) to determine the location of the antigen in carcinoma and normal cells. Sera from healthy volunteers (n = 147) and cancer patients (n = 26) were compared for both bound and total antigen concentrations using the new ELISA. Healthy volunteers were subdivided into three groups: those with a personal history of cancer …

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Roles And Regulation Of Nf-Κb In Platelet-Derived Growth Factor Transformed Cells, Takeshi Shimamura

Dissertations

Platelet-derived growth factor (PDGF) is overexpressed in various cancer cells and the overexpression may be correlated with the prognosis of several types of cancers. Binding of PDGF to its receptors induces receptor dimerization and subsequent autophosphorylation of tyrosine residues in the receptor’s cytoplasmic domains. The phosphorylated tyrosine residues interact with the secondary signaling molecules to initiate signaling cascades that trigger cellular changes by affecting downstream effectors. In our recent publication, we have shown that a NF-κB mediates the transformation of mouse fibroblast cells overexpressing PDGF B chain. Though there is a significant correlation between PDGF stimulation and NF-κB activity, it …

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Toxoplasma Gondii Induces Granulocyte Colony-Stimulating Factor And Granulocyte-Macrophage Colony-Stimulating Factor Secretion By Human Fibroblasts: Implications For Neutrophil Apoptosis, Jacqueline Y. Channon, Kristin A. Miselis, Laurie A. Minns, Chaitali Dutta, Lloyd H. Kasper

Dartmouth Scholarship

Human neutrophils are rescued from apoptosis following incubation with once-washed, fibroblast-derived Toxoplasma gondii tachyzoites. Both infected and uninfected neutrophils are rescued, implicating a soluble mediator. In this study we investigated the origin and identity of this soluble mediator. Neutrophils were incubated either with purified tachyzoites or with conditioned medium derived from T. gondii-infected human fibroblasts. Conditioned medium was found to be a potent stimulus that delayed neutrophil apoptosis up to 72 h, whereas purified and extensively washed tachyzoites had no effect. Delayed apoptosis correlated with up-regulation of the neutrophil antiapoptotic protein, Mcl-1, and the neutrophil interleukin 3 receptor alpha subunit …

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Topical Micronutrient Delivery System And Uses Of Thereof, Elaine L. Jacobson, Myron Jacobson, Jaber G. Qasem, Hyuntae Kim, Moonsun Kim

Graduate Center for Nutritional Sciences Faculty Patents

The invention involves methods and compositions useful in delivering micronutrients to cells. By formulating the micronutrient in the form of an ester that is convertible to the active form of the micronutrient, one can combine it with a co-ester that inhibits esterases, so that the micronutrient can reach the targeted cells prior to degradation. Both methods and compositions are described.

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The Influence Of Warning Label Presentation In Memory Recognition Of Aging Adults, Brian J. Call

Master's Theses - Daytona Beach

Research indicates that hundreds of thousands of people are injured each year as a result of poor communication between medical personnel, warning label information, and consumers when taking over the counter or prescription medication. Typically, as adults age, they are increasingly responsible for remembering the hazards of taking medications. If inadequate information exists in memory in regards to side effects, dosage, and other warnings, the likelihood of improper usage will increase. Because aging adults typically have a reduction in cognitive resources, it was hypothesized that older adults would require the aid of additional warning information to assist in the retrieval …

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Full-Text Articles in Entire DC Network

South Carolina Statewide Science Safety Project., Linda Sinclair, Jack Gerlovich, Rahul A. Parsa

Journal of the South Carolina Academy of Science

Some Notes On Multiplicative Congruential Random Number Generators With Mersenne Prime Modulus 261-1., James Harris

Journal of the South Carolina Academy of Science

Maternal And Sibling Influences On Seed Germination Of Aegilops Triuncialis Erin, Erin Scott, Andrew R. Dyer

Journal of the South Carolina Academy of Science

Scas Officers And Council Members 2003 - 2004

Journal of the South Carolina Academy of Science

Critical Thinking And Biology Instruction., David J. Stroup, John L. Frola

Journal of the South Carolina Academy of Science

Peritoneal Defense Mechanisms, Toni̇ Hau

Turkish Journal of Medical Sciences

Drug Resistance In Acute Leukaemia And Reversion, Jean-Pierre Marie, Ollivier Legrand

Turkish Journal of Medical Sciences

Bioavailability Of The Tea Flavonoids Epicatechin And Epicatechin Gallate: Role Of Membrane Transport And Metabolism, Jaya Bharathi Vaidyanathan

MUSC Theses and Dissertations

A Contrast-Based Neural Control System For Ant Navigation, Joanna R. Wares, Predrag-Peter Ilich, Daniel P. Dougherty

Department of Math & Statistics Faculty Publications

Nucleotide Excision Repair- And Polymerase Eta-Mediated Error-Prone Removal Of Mitomycin C Interstrand Cross-Links, H. Zheng, X. Wang, A. J. Warren, R. J. Legerski, Rodney S. Nairn, Joshua W. Hamilton, Lei Li

Dartmouth Scholarship

Genetic Health And Eugenics Precedents: A Voice Of Caution, Larry I. Palmer

Faculty Publications

Animal Anti-Apoptotic Genes Ameliorate The Loss Of Turgor In Water-Stressed Transgenic Tobacco, Tala Awada, D. D. Dunigan, M. B. Dickman

Nebraska Center for Virology: Faculty Publications

Identification Of Novel Domains Within Sox-2 And Sox-11 Involved In Autoinhibition Of Dna Binding And Partnership Specificity, Matthew S. Wiebe, Tamara K. Nowling, Angie Rizzino

Nebraska Center for Virology: Faculty Publications

Osmosensitive Taurine Release: Does Taurine Share The Same Efflux Pathway With Chloride And Other Amino Acid Osmolytes?, Rodrigo Franco

School of Veterinary and Biomedical Sciences: Faculty Publications

Role Of Activator Protein-1 In The Down-Regulation Of The Human Cyp2j2 Gene In Hypoxia, Nicole Y. Marden, Eva Fiala-Beer, Shi-Hua Xiang, Michael Murray

School of Veterinary and Biomedical Sciences: Faculty Publications

School of Veterinary and Biomedical Sciences: Faculty Publications

Method To Detect The Presence Of A Microorganism Or Agent In An Animal, David R. Smith, Laura L. Hungerford, Rodney A. Moxley, Susanne Hinkley, Terry Klopfenstein, Jeff Gray

School of Veterinary and Biomedical Sciences: Faculty Publications

Myosin Heavy Chain And Physiological Adaptation Of The Rat Diaphragm In Elastase-Induced Emphysema., Dong Kwan Kim, Jianliang Zhu, Benjamin W Kozyak, James M Burkman, Neal A Rubinstein, Edward B Lankford, Hansell H Stedman, Taitan Nguyen, Sanford Levine, Joseph B Shrager

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Faculty Publications 2002, Lsu Health Sciences Center New Orleans

Historical Faculty Publications

Saru, A Sara Homolog, Is Repressed By Sart And Regulates Virulence Genes In Staphylococcus Aureus, Adhar C. Manna, Ambrose L. Cheung

Dartmouth Scholarship

Vitamin D Dependent Down Regulation Of Arf1 Gene In Human Leukemia Cell Line Hl-60, Hakan Savli

Turkish Journal of Medical Sciences

Dose-Response Effects Of Lithium On Spatial Memory In The Black Molly Fish., Thomas Kyle Creson

Electronic Theses and Dissertations

Activation Of Ca2+-Activated K+ Channels And Cell Migration By Hepatocyte Growth Factor/Scatter Factor In Madin-Darby Canine Kidney Cells., Min Jin

Electronic Theses and Dissertations

Mentha (Lamiaceae) Phylogenetic Analysis Using Chloroplast Trnl-Trnf And Nuclear Ribosomal Dna Its Sequences, Jiranan Bunsawatt

Masters Theses & Specialist Projects

Review Of "The Human Embryonic Stem Cell Debate: Science, Ethics, And Public Policy (Basic Bioethics)," Edited By Suzanne Holland, Karen Lebacqz, And Laurie Zoloth, James Steele

The University of New Hampshire Law Review

A New Immunoassay For Quantification Of A Novel Cancer Antigen In Serum And Immunostaining Of Carcinoma Tissues And Cultured Cells Revealing The Antigenic Cellular Location., Emily Christine Mcduffee

Electronic Theses and Dissertations

Roles And Regulation Of Nf-Κb In Platelet-Derived Growth Factor Transformed Cells, Takeshi Shimamura

Dissertations

Toxoplasma Gondii Induces Granulocyte Colony-Stimulating Factor And Granulocyte-Macrophage Colony-Stimulating Factor Secretion By Human Fibroblasts: Implications For Neutrophil Apoptosis, Jacqueline Y. Channon, Kristin A. Miselis, Laurie A. Minns, Chaitali Dutta, Lloyd H. Kasper

Dartmouth Scholarship

Topical Micronutrient Delivery System And Uses Of Thereof, Elaine L. Jacobson, Myron Jacobson, Jaber G. Qasem, Hyuntae Kim, Moonsun Kim

Graduate Center for Nutritional Sciences Faculty Patents

The Influence Of Warning Label Presentation In Memory Recognition Of Aging Adults, Brian J. Call

Master's Theses - Daytona Beach