Open Access. Powered by Scholars. Published by Universities.®
- Institution
-
- The Texas Medical Center Library (10666)
- TÜBİTAK (1464)
- Thomas Jefferson University (1300)
- University of Nebraska - Lincoln (816)
- University of Kentucky (811)
-
- University of Alabama at Birmingham (789)
- Dartmouth College (448)
- University of Nebraska Medical Center (412)
- Touro College and University System (386)
- LSU Health New Orleans (362)
- Virginia Commonwealth University (329)
- Chulalongkorn University (303)
- Zucker School of Medicine at Hofstra/Northwell (290)
- Chapman University (285)
- Marshall University (273)
- Wright State University (263)
- University of South Carolina (256)
- University of Tennessee Health Science Center (229)
- Himmelfarb Health Sciences Library, The George Washington University (174)
- Loma Linda University (169)
- Edith Cowan University (165)
- Rowan University (163)
- Wayne State University (161)
- Old Dominion University (154)
- University of South Florida (132)
- City University of New York (CUNY) (119)
- University of Central Florida (118)
- Marquette University (114)
- Children's Mercy Kansas City (107)
- University of Texas Rio Grande Valley (107)
- Keyword
-
- Humans (7221)
- Animals (3450)
- Female (2709)
- Mice (2441)
- Male (2345)
-
- Adult (1100)
- Middle Aged (1013)
- Aged (855)
- Tumor (824)
- Doctor of Philosophy (PhD) Heersink School of Medicine (746)
- Cell Line (695)
- Mutation (675)
- Child (660)
- Neoplasms (653)
- Cell Line, Tumor (574)
- Biomarkers (568)
- Receptors (534)
- Carcinoma (497)
- Animal (483)
- Inbred C57BL (477)
- Signal Transduction (476)
- Inflammation (475)
- Mice, Inbred C57BL (468)
- Adolescent (466)
- Gene Expression Regulation (463)
- Immunotherapy (461)
- Tumor Microenvironment (423)
- RNA (419)
- Disease Models, Animal (417)
- Cancer (412)
- Publication Year
- Publication
-
- Faculty, Staff and Student Publications (5432)
- Faculty, Staff and Students Publications (4284)
- Turkish Journal of Medical Sciences (1464)
- All ETDs from UAB (785)
- Dartmouth Scholarship (439)
-
- School of Veterinary and Biomedical Sciences: Faculty Publications (329)
- Theses and Dissertations (300)
- Journal Articles (293)
- Chulalongkorn University Theses and Dissertations (Chula ETD) (288)
- Department of Pathology, Anatomy, and Cell Biology Faculty Papers (288)
- InTouch (277)
- Nebraska Center for Virology: Faculty Publications (265)
- Theses and Dissertations (ETD) (217)
- Department of Biochemistry and Molecular Biology Faculty Papers (209)
- Children’s Nutrition Research Center Staff Publications (208)
- School of Medicine Faculty Publications (202)
- Dissertations and Theses (Open Access) (201)
- Electronic Theses and Dissertations (189)
- Journal Articles: Biochemistry & Molecular Biology (188)
- Duncan NRI Faculty and Staff Publications (174)
- Pharmacy Faculty Articles and Research (163)
- Loma Linda University Electronic Theses, Dissertations & Projects (152)
- The Brown Foundation: Institute of Molecular Medicine (144)
- Biological Sciences Faculty Publications (131)
- Journal of the South Carolina Academy of Science (129)
- Center for Medical Ethics and Health Policy Staff Publications (118)
- Microbiology, Immunology, and Tropical Medicine Faculty Publications (107)
- Theses, Dissertations and Capstones (104)
- Manuscripts, Articles, Book Chapters and Other Papers (102)
- Microbiology, Immunology, and Molecular Genetics Faculty Publications (102)
- Publication Type
- File Type
Articles 16141 - 16170 of 24787
Full-Text Articles in Entire DC Network
Mango Ginger (Curcuma Amada) Inhibits Collagen-Induced Arthritis By Modulatinginflammatory Cytokine Levels In Rats, Ahmet Karataş, Cemal Orhan, Mehmet Tuzcu, Nurhan Şahi̇n, İbrahi̇m Hani̇fi̇ Özercan, Süleyman Serdar Koca, Vijaya Juturu, Kazi̇m Şahi̇n
Mango Ginger (Curcuma Amada) Inhibits Collagen-Induced Arthritis By Modulatinginflammatory Cytokine Levels In Rats, Ahmet Karataş, Cemal Orhan, Mehmet Tuzcu, Nurhan Şahi̇n, İbrahi̇m Hani̇fi̇ Özercan, Süleyman Serdar Koca, Vijaya Juturu, Kazi̇m Şahi̇n
Turkish Journal of Medical Sciences
Background/aim: Mango ginger (MG: curcuma amada) has antioxidant and antiinflammatory activities. The aim was to evaluate the antiarthritic potential efficacy of MG on collagen-induced arthritis. Materials and methods: Twenty-one female Wistar-albino rats were divided into three groups. Arthritis was induced by intradermal injections of type II collagen and Freund's adjuvant. MG extract was orally administered starting from the first collagen injection. TNF-α, IL-6, IL-17, obestatin, sclerostin, and DKK-1 serum levels were determined, and perisynovial inflammation and cartilage-bone destruction in the paws were histologically evaluated. Moreover, joint tissue TNF-α, IL-17, NF-κB, and COX-2 levels were analyzed. Results: TNF-α, IL-17, IL-6, and …
Covid-19 Outbreak Control, Example Of Ministry Of Health Of Turkey, Yasemi̇n Demi̇rbi̇lek, Gülen Pehli̇vantürk, Zeynep Özge Özgüler, Emi̇ne Alp Meşe
Covid-19 Outbreak Control, Example Of Ministry Of Health Of Turkey, Yasemi̇n Demi̇rbi̇lek, Gülen Pehli̇vantürk, Zeynep Özge Özgüler, Emi̇ne Alp Meşe
Turkish Journal of Medical Sciences
Our first COVID-19 case in Turkey was a 44-year-old male who referred to the hospital on March 9, 2020. The first related death occurred on March 17, 2020. Preparedness for the pandemic has been ongoing before the first case was detected. The National Pandemic Plan was published in 2006. The Pandemic Influenza National Preparedness Plan was available after being updated in light of experiences gained during the 2009 Influenza A pandemic. Accordingly, Pandemic Coordination Boards and Operation Centers have been established on the national and provincial levels. This was an adaptable plan to the Novel Coronavirus Disease (COVID-19). We formed …
Protective Measures For Covid-19 For Healthcare Providers And Laboratory Personnel, Canan Ağalar, Derya Öztürk Engi̇n
Protective Measures For Covid-19 For Healthcare Providers And Laboratory Personnel, Canan Ağalar, Derya Öztürk Engi̇n
Turkish Journal of Medical Sciences
In the COVID-19 pandemic, which affects the whole world, healthcare professionals (HCP) are at high risk of transmission due to their direct contact with patients with COVID-19. Therefore, how to ensure the triage of the patient with acute respiratory symptoms should be determined in advance, the contact distance should be arranged to be at least 2 m, COVID-19 suspect or diagnosed patient should be instructed to wear a surgical mask. During the care of these patients, HCP should wear their personal protective equipment (PPE) in accordance with the procedure and should not neglect hand hygiene. The samples of the patient …
The Early Impact Of The Covid-19 Pandemic On The Global And Turkish Economy, Ömer Açikgöz, Asli Günay
The Early Impact Of The Covid-19 Pandemic On The Global And Turkish Economy, Ömer Açikgöz, Asli Günay
Turkish Journal of Medical Sciences
Background/aim: Individuals infected by the Covid-19 potentially are at risk of health and economic well-being. Today, the Covid-19 is a global issue, and the world economy can be interpreted as almost at the standstill. In this context, this study aims to discuss the potential first reactions of short and long term global economic impacts of the pandemic through sectors by assessing its costs according to the data announced for both the world and Turkey. In addition, this study tries to put forth possible economic and political scenarios for the post-pandemic world. Materials and methods: This is a review article that …
Global Surveillance, Travel, And Trade During A Pandemic, Ceren Çeti̇n, Ateş Kara
Global Surveillance, Travel, And Trade During A Pandemic, Ceren Çeti̇n, Ateş Kara
Turkish Journal of Medical Sciences
Pandemics have had very important consequences in human history. Lots of people lost their lives and countries have been intensively affected in terms of socioeconomic problems. Unfortunately, avoidance of pandemics and limiting the spread are still currently not always possible. Maybe the most important factor for this is the increasing frequency of traveling. Increasing airline traveling rate also increases the rate of spread. Global organizations like the World Health Organization and United Nations are trying to play a supreme role over the countries. Pandemics do not have borders; therefore, efforts should be given globally, definition of pandemic should be established …
Quarantine And Its Legal Dimension, Rahmi̇ Kiliç, Çi̇ğdem Ataman Hati̇poğlu, Cemi̇l Güneş
Quarantine And Its Legal Dimension, Rahmi̇ Kiliç, Çi̇ğdem Ataman Hati̇poğlu, Cemi̇l Güneş
Turkish Journal of Medical Sciences
Quarantine and isolation are public health measures used for centuries to prevent the spread of infectious diseases. Quarantine is separation of persons who have been exposed to an infection but asymptomatic, while isolation is separation of infected patients. Voluntary quarantine is preferred, but if necessary, it can be mandatory. These implementations can lead to restrictions on individual liberties, leading to ethical and legal problems. Isolation and quarantine enforcement are regulated by laws. Those who do not follow the quarantine rules could be punished. Isolation and quarantine practices in our country are described in General Hygiene Law. In this study the …
Coronaviruses And Sars-Cov-2, Mustafa Hasöksüz, Selçuk Kiliç, Fahri̇ye Saraç
Coronaviruses And Sars-Cov-2, Mustafa Hasöksüz, Selçuk Kiliç, Fahri̇ye Saraç
Turkish Journal of Medical Sciences
Coronaviruses (CoVs) cause a broad spectrum of diseases in domestic and wild animals, poultry, and rodents, ranging from mild to severe enteric, respiratory, and systemic disease, and also cause the common cold or pneumonia in humans. Seven coronavirus species are known to cause human infection, 4 of which, HCoV 229E, HCoV NL63, HCoV HKU1 and HCoV OC43, typically cause cold symptoms in immunocompetent individuals. The others namely SARS-CoV (severe acute respiratory syndrome coronavirus), MERS-CoV (Middle East respiratory syndrome coronavirus) were zoonotic in origin and cause severe respiratory illness and fatalities. On 31 December 2019, the existence of patients with pneumonia …
Covid-19, Immune System Response, Hyperinflammation And Repurposingantirheumatic Drugs, Abdurrahman Tufan, Aslihan Avanoğlu Güler, Marco Matucci-Cerinic
Covid-19, Immune System Response, Hyperinflammation And Repurposingantirheumatic Drugs, Abdurrahman Tufan, Aslihan Avanoğlu Güler, Marco Matucci-Cerinic
Turkish Journal of Medical Sciences
In the Wuhan Province of China, in December 2019, the novel coronavirus 2019 (COVID-19) has caused a severe involvement of the lower respiratory tract leading to an acute respiratory syndrome. Subsequently, coronavirus 2 (SARS-CoV-2) provoked a pandemic which is considered a life-threatening disease. The SARS-CoV-2, a family member of betacoronaviruses, possesses singlestranded positive-sense RNA with typical structural proteins, involving the envelope, membrane, nucleocapsid and spike proteins that are responsible for the viral infectivity, and nonstructural proteins. The effectual host immune response including innate and adaptive immunity against SARS-Cov-2 seems crucial to control and resolve the viral infection. However, the severity …
Anti-Interleukin-6 (Tocilizumab) Therapy In Takayasu's Arteritis: A Real Life Experience, Levent Kiliç, Ömer Karadağ, Abdulsamet Erden, Alper Sari, Berkan Armağan, Gözde Kübra Yardimci, Esra Firat Şentürk, Umut Kalyoncu, Şazi̇ye Şule Apraş Bi̇lgen, Sedat Ki̇raz, Ali̇ İhsan Ertenli̇, Ali̇ Akdoğan
Anti-Interleukin-6 (Tocilizumab) Therapy In Takayasu's Arteritis: A Real Life Experience, Levent Kiliç, Ömer Karadağ, Abdulsamet Erden, Alper Sari, Berkan Armağan, Gözde Kübra Yardimci, Esra Firat Şentürk, Umut Kalyoncu, Şazi̇ye Şule Apraş Bi̇lgen, Sedat Ki̇raz, Ali̇ İhsan Ertenli̇, Ali̇ Akdoğan
Turkish Journal of Medical Sciences
Background/aim: Tumour necrosis factor inhibitors and anti-interleukin-6 (anti-IL-6) therapies are increasingly being used in Takayasu's arteritis (TA) patients who are unresponsive to corticosteroids ± conventional immunosuppressive agents.The aim of this study is to assess the efficacy and safety of anti-IL-6 (tocilizumab) therapy in refractory TA patients in real life.Materials and methods: Fifteen TA patients (86.7% were female) who received at least 3 cycles of tocilizumab therapy were retrospectively assessed by clinical, laboratory, and radiological evaluations before and after tocilizumab therapy. Results: The median (min-max) age of the patients at evaluation was 35 (20-58) years and the median disease duration from …
Twenty Children With Non-Wilms Renal Tumors From A Reference Center In Central Anatolia, Turkey, Ekrem Ünal, Ebru Yilmaz, Alper Özcan, Bi̇lgen Işik, Musa Karakükcü, Cüneyt Turan, Hülya Akgün, Fi̇gen Öztürk, Abdulhaki̇m Coşkun, Mehmet Aki̇f Özdemi̇r, Türkan Patiroğlu
Twenty Children With Non-Wilms Renal Tumors From A Reference Center In Central Anatolia, Turkey, Ekrem Ünal, Ebru Yilmaz, Alper Özcan, Bi̇lgen Işik, Musa Karakükcü, Cüneyt Turan, Hülya Akgün, Fi̇gen Öztürk, Abdulhaki̇m Coşkun, Mehmet Aki̇f Özdemi̇r, Türkan Patiroğlu
Turkish Journal of Medical Sciences
Background/aim: Non-Wilms renal tumors (NWRTs) are rarely encountered in children. The aim of this study is to determine the treatment strategies, prognosis, outcomes, and survival of children with NWRTs at Erciyes University in Kayseri, Turkey.Materials and methods: Medical records of all patients (n = 20) treated for NWRTs over a 23-year period (1995-2018) were reviewed retrospectively.Results: There was male predominance (female/male: 7/13); the median age at diagnosis was 3.2 years old (0.1-13.5 years old). The major histological groups included mesoblastic nephroma (MBN), (n: 5, 25%), malignant rhabdoid tumor (MRT), (n: 5, 25%), renal cell carcinoma, (n: 3, 15%), inflammatory myofibroblastic …
Can Postoperative Pain Be Predicted? New Parameter: Analgesia Nociception Index, Ali̇ Şefi̇k Köprülü, Ali̇ Haspolat, Yaşar Gökhan Gül, Nurşen Tanrikulu
Can Postoperative Pain Be Predicted? New Parameter: Analgesia Nociception Index, Ali̇ Şefi̇k Köprülü, Ali̇ Haspolat, Yaşar Gökhan Gül, Nurşen Tanrikulu
Turkish Journal of Medical Sciences
Background/aim: The Analgesia Nociception Index (ANI) is a new method of identifying nociception-analgesia balance. In this study, we investigate the correlation between the ANI and numeric rating scale (NRS) values immediately before and after extubation. The NRS values were recorded in the postanesthesia care unit, in a group of patients who underwent laparoscopic cholecystectomy, with the aim of evaluating the potential use of ANI values in the prediction of postoperative pain levels.Materials and methods: The ANI and NRS values, heartbeat rate (HR), systolic and diastolic arterial pressure (SAP/DAP), and oxygen saturation (SpO2) values of the patients were recorded into three …
Thiol/Disulfide Homeostasis And Ischemia Modified Albumin Levels In Autoimmune Gastritis And Their Relations With Gastric Emptying, Emra Asfuroğlu Kalkan, Serap Boz, Özcan Erel, Sali̇m Neşeli̇oğlu, Çağdaş Kalkan, Ari̇f İrfan Soykan
Thiol/Disulfide Homeostasis And Ischemia Modified Albumin Levels In Autoimmune Gastritis And Their Relations With Gastric Emptying, Emra Asfuroğlu Kalkan, Serap Boz, Özcan Erel, Sali̇m Neşeli̇oğlu, Çağdaş Kalkan, Ari̇f İrfan Soykan
Turkish Journal of Medical Sciences
Background/aim: Autoimmune gastritis is an autoimmune and inflammatory disorder. The aim of this study is to examine dynamic thiol/disulfide homeostasis and ischemia modified albumin levels, and to analyze the association between thiol/disulfide homeostasis and gastric emptying time in autoimmune gastritis. Materials and methods: Thiol/disulfide homeostasis tests and ischemia modified albumin levels were determined in 50 autoimmune gastritis patients and 53 healthy subjects. Patients with delayed and normal gastric emptying were compared by thiol/disulfide homeostasis tests. Results: The results showed that native thiol (μmol/L), total thiol (μmol/L), and native thiol/total thiol ratio (%) of the patients with autoimmune gastritis decreased compared …
Early Pregnancy After Bariatric Surgery: A Single-Institute Preliminary Experience, Emre Günakan, Hakan Buluş, Yusuf Aytaç Tohma
Early Pregnancy After Bariatric Surgery: A Single-Institute Preliminary Experience, Emre Günakan, Hakan Buluş, Yusuf Aytaç Tohma
Turkish Journal of Medical Sciences
Background/aim: Pregnancy after bariatric surgery is an issue of growing importance with increasing number of women undergoing bariatric surgery. Therefore, in this study we present patients who conceived after sleeve gastrectomy and evaluate the obstetric outcomes. Materials and methods: This retrospective case-control study includes 23 women who conceived after laparoscopic sleeve gastrectomy. Patients were evaluated in two groups according to the number of months between surgery and conception (group 1: ≤12 months; group 2: >12 months). Results: The mean body mass index of patients before surgery and at the time of conception was 46.6 kg/m2 and 29.7 kg/m2, respectively. Nine …
Avascular Necrosis Less Frequently Found In Systemic Lupus Erythematosus Patients With The Use Of Alternate Day Corticosteroid, İsmai̇l Doğan, Umut Kalyoncu, Levent Kiliç, Ali̇ Akdoğan, Ömer Karadağ, Sedat Ki̇raz, Şazi̇ye Şule Apraş Bi̇lgen, Ali̇ İhsan Ertenli̇
Avascular Necrosis Less Frequently Found In Systemic Lupus Erythematosus Patients With The Use Of Alternate Day Corticosteroid, İsmai̇l Doğan, Umut Kalyoncu, Levent Kiliç, Ali̇ Akdoğan, Ömer Karadağ, Sedat Ki̇raz, Şazi̇ye Şule Apraş Bi̇lgen, Ali̇ İhsan Ertenli̇
Turkish Journal of Medical Sciences
Background/aim: Avascular necrosis (AVN) is the death of bone due to compromise of blood flow. The etiology of AVN is multifactorial; corticosteroid usage is the second most significant factor after trauma, and systemic lupus erythematosus (SLE) is the most common underlying disease. The objective of this study was to assess the factors of AVN in SLE patients. Materials and methods: The study included 127 patients with SLE who fulfilled 1997 American College of Rheumatology (ACR) revised criteria. Demographic data, age at SLE diagnosis, disease duration, disease activity, body mass index, clinical findings, antiphospholipid syndrome, steroid usage, dose and duration, comorbid …
Characterization Of Silk Sutures Coated With Propolis And Biogenic Silver Nanoparticles (Agnps); An Eco-Friendly Solution With Wound Healing Potential Against Surgical Site Infections (Ssis), Tuba Baygar
Turkish Journal of Medical Sciences
Background/aim: Bacterial adherence to a suture material is one of the main causes of surgical site infections. An antibacterial suture material with enhanced wound healing function may protect the surgical site from infections. Thus, the present study aimed to investigate the synergistic effect of propolis and biogenic metallic nanoparticles when combined with silk sutures for biomedical use.Materials and methods: Silver nanoparticle (AgNP) synthesis was carried out via a microbial-mediated biological route and impregnated on propolis-loaded silk sutures using an in situ process. Silk sutures fabricated with propolis and biosynthesized AgNPs (bioAgNP-propolis-coated sutures) were intensively characterized using scanning electron microscopy (SEM), …
An Evaluation Of The Effects Of Caffeic Acid Phenethyl Ester And Ankaferd Blood Stopper On Secondary Wound Healing Of Oral Mucosal Tissue, Mehmet Gül, Ahmet Günay, Abdulsamet Tanik
An Evaluation Of The Effects Of Caffeic Acid Phenethyl Ester And Ankaferd Blood Stopper On Secondary Wound Healing Of Oral Mucosal Tissue, Mehmet Gül, Ahmet Günay, Abdulsamet Tanik
Turkish Journal of Medical Sciences
Background/aim: Caffeic acid phenethyl ester (CAPE) and Ankaferd Blood Stopper (ABS) are considered to contribute to wound healing. The purpose of this study was to investigate the effect of ABS and CAPE on secondary wound healing of oral mucosal tissue. Materials and methods: In total, 63 male Sprague-Dawley rats were used in this study. The animals were randomly divided into three groups and anaesthetized with ketamine (8 mg/100 g, intraperitoneally): a control group, CAPE group, and ABS group. A full-thickness excisional wound was created using a 4 mm punch biopsy tool. Topical ABS and CAPE were then applied in each …
Carvacrol Alters Soluble Factors In Hct-116 And Ht-29 Cell Lines, Ahu Pakdemi̇rli̇, Caner Karaca, Tolga Sever, Ezgi̇ Daşkin, Asim Leblebi̇ci̇, Türkan Yi̇ği̇tbaşi, Yasemi̇n Başbinar
Carvacrol Alters Soluble Factors In Hct-116 And Ht-29 Cell Lines, Ahu Pakdemi̇rli̇, Caner Karaca, Tolga Sever, Ezgi̇ Daşkin, Asim Leblebi̇ci̇, Türkan Yi̇ği̇tbaşi, Yasemi̇n Başbinar
Turkish Journal of Medical Sciences
Background/aim: Natural products are popular insights for researchers to investigate promising anti-cancer agents since some of these substances have lesser adverse effects restricting the treatment than traditional chemotherapeutic agents. A well-known monoterpene Carvacrol, widely consumed in Mediterranean cuisine and lower risks of cancer, has efficient anticancer effects. However, the mechanism of action is yet to be discovered. Materials and methods: The investigation aims to illuminate a new perceptive in the role of this substance on colorectal cancer treatment, by the means of differences in a well-defined range of soluble factors. Carvacrol effect on both HT-29 and HCT-116 cell lines was …
25-Hydroxy Vitamin D Level Is Associated With Sleep Disturbances In Patients With Chronickidney Disease On Hemodialysis: A Cross-Sectional Study, Demet Yavuz, Rahman Yavuz, Mehmet Derya Demi̇rağ, Düri̇ye Sila Karagöz Özen, Zeynep Banu Ramazanoğlu
25-Hydroxy Vitamin D Level Is Associated With Sleep Disturbances In Patients With Chronickidney Disease On Hemodialysis: A Cross-Sectional Study, Demet Yavuz, Rahman Yavuz, Mehmet Derya Demi̇rağ, Düri̇ye Sila Karagöz Özen, Zeynep Banu Ramazanoğlu
Turkish Journal of Medical Sciences
Background/aim: Deficient levels of vitamin D are an important factor in the pathogenesis of some neurodegenerative diseases. The aim of this study is to determine the relationship between vitamin D deficiency and depression status and sleep disorders of patients on dialysis. Materials and methods: In this cross-sectional study, 121 hemodialysis patients were enrolled. All patients had been on hemodialysis for at least six months at the time of the study. Sleep quality and depression status were measured by using specific inventories. All the patients filled out Pittsburg Sleep Quality Index (PSQI) and Beck Depression Inventory (BDI), and gave blood samples. …
Adiponectin Levels Decrease Independently Of Body Mass Index And Diabetes Type Afterthe Normalization Of Hyperglycemia, Nalan Meti̇n Aksu, Duygu Yazgan Aksoy, Meltem Akkaş, Neşe Çinar, Fatma Uçar, Okan Bülent Yildiz, Aydan Usman
Adiponectin Levels Decrease Independently Of Body Mass Index And Diabetes Type Afterthe Normalization Of Hyperglycemia, Nalan Meti̇n Aksu, Duygu Yazgan Aksoy, Meltem Akkaş, Neşe Çinar, Fatma Uçar, Okan Bülent Yildiz, Aydan Usman
Turkish Journal of Medical Sciences
Background/aim: Acute hyperglycemia is generally a frequently encountered condition in the emergency department (ED), because it is seen as a complication of diabetes mellitus (DM). In this study, we aimed to detect the change in adiponectin levels during acute hyperglycemic states and after normalization of blood glucose with insulin treatment. Materials and methods: Forty-eight patients over the age of 18 years who were admitted to the ED with acute hyperglycemia were included in the study. Serum samples were taken from patients on admission and 6 h after the normalization of blood glucose with insulin treatment, and adiponectin levels were measured …
The Clinicopathologic Characteristics Of Familial And Sporadic Papillary Thyroidcarcinoma In Turkish Patients, Havva Sezer, Mehmet Onur Demi̇rkol, Di̇lek Yazici, Yersu Kapran, Mahmut Faruk Alagöl
The Clinicopathologic Characteristics Of Familial And Sporadic Papillary Thyroidcarcinoma In Turkish Patients, Havva Sezer, Mehmet Onur Demi̇rkol, Di̇lek Yazici, Yersu Kapran, Mahmut Faruk Alagöl
Turkish Journal of Medical Sciences
Background/aim: The aim of this study is to investigate clinicopathologic features of familial papillary thyroid carcinoma (fPTC) and compare them with sporadic papillary thyroid carcinoma (sPTC) in Turkish patients. A retrospective analysis of the papillary thyroid carcinoma (PTC) cases, with or without family history with a follow-up around 10 years was performed. Materials and methods: A series of patients with fPTC (82 fPTC families with 146 affected individuals) were compared with patients with sPTC (n = 112). The clinicopathologic features [(age, gender, histologic subtype, tumour size, bilaterality, multifocality, extrathyroidal extension (ETE), lymph node metastasis (LNM)] and treatment procedures (lymph node …
What Is The Effect Of The Early Follicular Phase Fsh/Lh Ratio On The Number Of Matureoocytes And Embryo Development?, Özgür Arat, Şükri̇ye Derya Deveci̇, Zehra Sema Özkan, Sevi̇m Tuncer Can
What Is The Effect Of The Early Follicular Phase Fsh/Lh Ratio On The Number Of Matureoocytes And Embryo Development?, Özgür Arat, Şükri̇ye Derya Deveci̇, Zehra Sema Özkan, Sevi̇m Tuncer Can
Turkish Journal of Medical Sciences
Background/aim: Basal level of follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), and antral follicle count are used as predictors of ovarian reserve before starting ovulation induction. We aimed to investigate the predictor potential of early follicular phase FSH/LH ratio on controlled ovarian hyperstimulation-intracytoplasmic sperm injection (COH-ICSI) cycle outcomes. Materials and methods: This retrospective cohort study was conducted with 648 COH-ICSI cycles performed between 2012 and 2014. Cycles were classified according to their basal FSH/LH ratio, group 1(G1) = FSH/LH ratio < 2, N = 473 and group 2(G2) = FSH/LH ratio ∠ 2, N = 175. Demographic characteristics and stimulation parameters were evaluated. Retrieved total oocyte count (TOC), mature oocyte count (MOC), transferred embryo number, and pregnancy results were obtained and transferred to computer by SPSS 21.0 programme. Results: TOC and MOC of G1 were significantly higher than those of G2. The total gonadotrophin doses of G2 were significantly higher than G1. There was no significant difference between groups for transferred embryo number. Pregnancy and live birth rates were similar in both groups. Conclusion: In our population, increased FSH/LH ratio did not affect the rates of pregnancy and live birth negatively.
Evaluation Of Cardiovascular Autonomic Dysfunction According To Heart Rate Turbulenceand Variability In Patients With Relapsing Remitting Multiple Sclerosis, Serkan Gökaslan, Hayri̇ Demi̇rbaş, Çi̇ğdem Özer Gökaslan
Evaluation Of Cardiovascular Autonomic Dysfunction According To Heart Rate Turbulenceand Variability In Patients With Relapsing Remitting Multiple Sclerosis, Serkan Gökaslan, Hayri̇ Demi̇rbaş, Çi̇ğdem Özer Gökaslan
Turkish Journal of Medical Sciences
Background/aim: Multiple sclerosis (MS) is an autoimmune disease characterized by neurodegeneration or demyelination; the relapsing-remitting phase of MS is characterized by acute exacerbation of disease activity. The most commonly used noninvasive approach to assess autonomic function is the determination of heart rate turbulence (HRT) and heart rate variability (HRV). The aim of this study was to evaluate the presence of cardiovascular autonomic dysfunction using HRT and HRV parameters determined via 24-h Holter ECG monitoring in patients with relapsing-remitting MS without known heart disease. Materials and methods: The study included 26 patients diagnosed with relapsing-remitting MS and 22 age- and sex-matched …
The In Vitro Cytotoxic, Genotoxic, And Oxidative Damage Potentials Of The Oral Artificialsweetener Aspartame On Cultured Human Blood Cells, Kenan Çadirci, Özlem Özdemi̇r Tozlu, Hasan Türkez, Adi̇l Mardi̇noğlu
The In Vitro Cytotoxic, Genotoxic, And Oxidative Damage Potentials Of The Oral Artificialsweetener Aspartame On Cultured Human Blood Cells, Kenan Çadirci, Özlem Özdemi̇r Tozlu, Hasan Türkez, Adi̇l Mardi̇noğlu
Turkish Journal of Medical Sciences
Background/aim: Aspartame (APM, L-aspartyl-L-phenylalanine methylester) is a low-calorie, nonsaccharide artificial sweetener widely used in foods and beverages. When metabolized by the body, APM is broken down into aspartic acid, phenylalanine amino acids, and a third substance, methanol. Since the amino acid phenylalanine serves as a neurotransmitter building block affecting the brain, and methanol is converted into toxic formaldehyde, APM has deleterious effects on the body and brain. Thus, its safety and, toxicity have been the subjects of concern ever since it was first discovered. Although many studies have been performed on it, due to the presence of conflicting data in …
Physiological And Pharmacological Roles Of Melatonin In The Pathophysiologicalcomponents Of Cellular Injury After Ischemic Stroke, Ertuğrul Kiliç, Berrak Çağlayan, Mustafa Caglar Beker
Physiological And Pharmacological Roles Of Melatonin In The Pathophysiologicalcomponents Of Cellular Injury After Ischemic Stroke, Ertuğrul Kiliç, Berrak Çağlayan, Mustafa Caglar Beker
Turkish Journal of Medical Sciences
Apart from its metabolic or physiological functions, melatonin has a potent cytoprotective activity in the physiological and pathological conditions. It is synthetized by the pineal gland and released into the blood circulation but particularly cerebrospinal fluid in a circadian manner. It can also easily diffuse through cellular membranes due its small size and lipophilic structure. Its cytoprotective activity has been linked to its potent free radical scavenger activity with the desirable characteristics of a clinically- reliable antioxidant. Melatonin detoxifies oxygen and nitrogen-based free radicals and oxidizing agents, including the highly toxic hydroxyl-and peroxynitrite radicals, initiating cellular damage. However, the cytoprotective …
Bmp And Tgfß Use And Release In Bone Regeneration, Zeynep Bal, Junichi Kushioka, Joe Kodama, Takashi Kaito, Hideki Yoshikawa, Petek Korkusuz, Feza Korkusuz
Bmp And Tgfß Use And Release In Bone Regeneration, Zeynep Bal, Junichi Kushioka, Joe Kodama, Takashi Kaito, Hideki Yoshikawa, Petek Korkusuz, Feza Korkusuz
Turkish Journal of Medical Sciences
A fracture that does not unite in nine months is defined as nonunion. Nonunion is common in fragmented fractures and large bone defects where vascularization is impaired. The distal third of the tibia, the scaphoid bone or the talus fractures are furthermore prone to nonunion. Open fractures and spinal fusion cases also need special monitoring for healing. Bone tissue regeneration can be attained by autografts, allografts, xenografts and synthetic materials, however their limited availability and the increased surgical time as well as the donor site morbidity of autograft use, and lower probability of success, increased costs and disease transmission and …
Tuberous Sclerosis: A Review Of The Past, Present, And Future, Sanem Pinar Uysal, Mustafa Şahi̇n
Tuberous Sclerosis: A Review Of The Past, Present, And Future, Sanem Pinar Uysal, Mustafa Şahi̇n
Turkish Journal of Medical Sciences
Tuberous sclerosis complex (TSC) is an autosomal dominant, multisystem disorder that is characterized by cellular and tissue dysplasia in several organs. With the advent of genetic and molecular techniques, mutations in the TSC1 or TSC2 genes were discovered to be responsible for mTOR overactivation, which is the underlying mechanism of pathogenesis. TSC is a highly heterogenous clinical entity with variable presentations and severity of disease. The brain, heart, skin, eyes, kidneys, and lungs are commonly involved in this syndrome, with neurologic symptoms comprising a significant source of morbidity and mortality. In 2012, the diagnostic criteria for TSC were revised by …
Igg4-Related Disease: A Contemporary Review, Hazan Karadeni̇z, Augusto Vaglio
Igg4-Related Disease: A Contemporary Review, Hazan Karadeni̇z, Augusto Vaglio
Turkish Journal of Medical Sciences
Background/aim: Immunoglobulin G4-related disease (IgG4-RD), is an immune-mediated fibroinflammatory condition, which may involve multiple organs and mostly presents with high serum IgG4 levels and specific histopathological characteristics. As IgG4-RD is a relatively new entity the etiology, prevalence and epidemiologic knowledge is quite limited. Although involvement of almost all anatomical regions has been reported, the most commonly affected regions are pancreas, lacrimal glands, salivary glands, retroperitoneum, orbita, lymph nodes, kidney and lungs. Diagnosis is made with combined evaluation of clinical, radiological and histopathological findings. Typical histopathological features include storiform fibrosis, dense lymphoplasmacytic infiltrates and obliterative phlebitis. Its course is typically marked …
Graft-Versus-Cancereffect And Innovative Approaches In Thetreatment Of Refractorysolid Tumors, Uğur Şahi̇n, Taner Demi̇rer
Graft-Versus-Cancereffect And Innovative Approaches In Thetreatment Of Refractorysolid Tumors, Uğur Şahi̇n, Taner Demi̇rer
Turkish Journal of Medical Sciences
Background/aim: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been used for the treatment of various refractory solid tumors during the last two decades. After the demonstration of graft-versus-leukemia (GvL) effect in a leukemic murine model following allo-HSCT from other strains of mice, graft-versus-tumor (GvT) effect in a solid tumor after allo-HSCT has also been reported in a murine model in 1984. Several trials have reported the presence of a GvT effect in patients with various refractory solid tumors, including renal, ovarian and colon cancers, as well as soft tissue sarcomas [1]. The growing data on haploidentical transplants also indicate GvT …
Ankaferd Hemostat: From Molecules To Medicine, Rafi̇ye Çi̇ftçi̇ler, İbrahi̇m Celaletti̇n Haznedaroğlu
Ankaferd Hemostat: From Molecules To Medicine, Rafi̇ye Çi̇ftçi̇ler, İbrahi̇m Celaletti̇n Haznedaroğlu
Turkish Journal of Medical Sciences
Ankaferd hemostat (ABS; Ankaferd Blood Stopper® , İstanbul, Turkey) is a hemostatic agent having an impact on red blood cell-fibrinogen interactions. The hemostatic effect of ABS depends upon the quick promotion of a protein network, particularly fibrinogen gamma, in relation to the erythrocyte aggregation. The entire physiological process involves ABS-induced formation of the protein network by vital erythrocyte aggregation. Vital erythrocyte aggregation occurs with the spectrine, ankyrin, and actin proteins on the membrane of the red blood cells. ABS notably affects cell metabolism and cell cycle mechanisms. Meanwhile, ABS has antiproliferative effects on cancer cells. The aim of this review …
Thiol-Disulfide Homeostasis: An Integrated Approach With Biochemical And Clinical Aspects, Özcan Erel, Serpi̇l Erdoğan
Thiol-Disulfide Homeostasis: An Integrated Approach With Biochemical And Clinical Aspects, Özcan Erel, Serpi̇l Erdoğan
Turkish Journal of Medical Sciences
Dynamic thiol-disulfide homeostasis (TDH) is a new area has begun to attract more scrutiny. Dynamic TDH is reversal of thiol oxidation in proteins and represents the status of thiols (-SH) and disulfides (-S-S-). Organic compounds containing the sulfhydryl group is called thiol, composed of sulfur and hydrogen atoms. Disulfides are the most important class of dynamic, redox responsive covalent bonds build in between two thiol groups. For many years, thiol levels were analyzed by several methods. During last years, measurements of disulfide levels have been analyzed by a novel automated method, developed by Erel and Neselioglu. In this method, addition …