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Full-Text Articles in Entire DC Network
Post-Covid Syndrome: Pulmonary Complications, Dori̇na Esendağli, Aydin Yilmaz, Müşerref Şule Akçay, Tevfi̇k Özlü
Post-Covid Syndrome: Pulmonary Complications, Dori̇na Esendağli, Aydin Yilmaz, Müşerref Şule Akçay, Tevfi̇k Özlü
Turkish Journal of Medical Sciences
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected millions of people worlwide and caused a pandemic that is still ongoing. The virus can cause a disease named as COVID-19, which is composed of multi systemic manifestations with a pulmonary system predominance. As the time passes, we are dealing more and more with a wide variety of effects and complications of the disease in survivors as far as with concerns about the clinical outcome and the timeline of symptoms in different patients. Since the lungs are the most involved organs and the post-COVID prolonged and persistent effects are mainly related …
Immune Dysfunction In Covid-19 And Judicious Use Of Antirheumatic Drugs For Thetreatment Of Hyperinflammation, Abdurrahman Tufan, Marco Matucci-Cerinic
Immune Dysfunction In Covid-19 And Judicious Use Of Antirheumatic Drugs For Thetreatment Of Hyperinflammation, Abdurrahman Tufan, Marco Matucci-Cerinic
Turkish Journal of Medical Sciences
: In the Wuhan province of China, almost two years ago, in December 2019, the novel Coronavirus 2019 has caused a severe involvement of the lower respiratory tract leading to an acute life-threatening respiratory syndrome, coronavirus disease-19 (COVID-19). Subsequently, coronavirus 2 (SARS-CoV-2) rapidly spread to the entire world causing a pandemic and affected every single person on earth either directly or indirectly with destroying all facets of social life and economy. Since the announcement of COVID-19 as a global pandemic, we have witnessed tremendous scientific work on all aspects of COVID-19 across the globe, which has never been witnessed before. …
An Update Of Anti-Viral Treatment Of Covid-19, Serap Yavuz, Feri̇de İpek Komsuoğlu Çeli̇kyurt
An Update Of Anti-Viral Treatment Of Covid-19, Serap Yavuz, Feri̇de İpek Komsuoğlu Çeli̇kyurt
Turkish Journal of Medical Sciences
Background/aim: Currently there is not an effective antiviral treatment for COVID-19, but a large number of drugs have been evaluated since the beginning of the pandemic, and many of them have been used for the treatment of COVID-19 despite the preliminary or conflicting results of the clinical trials. We aimed to review and summarize all of the current knowledge on the antivirals for COVID-19. Results: There are 2 main drug groups for SARS-CoV-2: agents that target proteins or RNA of the virus or interfere with proteins or biological processes in the host that support the virus. The main drug groups …
Dopamine Transporter Spect Imaging In Parkinson's Disease And Parkinsoniandisorders, Ümi̇t Özgür Akdemi̇r, Hati̇ce Ayşe Tokçaer Bora, Lütfi̇ye Özlem Atay
Dopamine Transporter Spect Imaging In Parkinson's Disease And Parkinsoniandisorders, Ümi̇t Özgür Akdemi̇r, Hati̇ce Ayşe Tokçaer Bora, Lütfi̇ye Özlem Atay
Turkish Journal of Medical Sciences
The dopamine transporter (DAT) imaging provides an objective tool for the assessment of dopaminergic function of presynaptic terminals which is valuable for the differential diagnosis of parkinsonian disorders related to a striatal dopaminergic deficiency from movement disorders not related a striatal dopaminergic deficiency. DAT imaging with single-photon emission computed tomography (SPECT) can be used to confirm or exclude a diagnosis of dopamine deficient parkinsonism in cases where the diagnosis is unclear. It can also detect the dopaminergic dysfunction in presymptomatic subjects at risk for Parkinson's disease (PD) since the reduced radiotracer binding to DATs in striatum is already present in …
Risk Factors For Evisceration In Gynecological Oncology Surgeries, Fati̇h Kiliç, Günsu Ki̇myon Cömert, Mehmet Ünsal, İsmet Çi̇ğdem Kiliç, Caner Çakir, Di̇lek Yüksel, Mustafa Alper Karalök, Osman Türkmen, Ahmet Taner Turan
Risk Factors For Evisceration In Gynecological Oncology Surgeries, Fati̇h Kiliç, Günsu Ki̇myon Cömert, Mehmet Ünsal, İsmet Çi̇ğdem Kiliç, Caner Çakir, Di̇lek Yüksel, Mustafa Alper Karalök, Osman Türkmen, Ahmet Taner Turan
Turkish Journal of Medical Sciences
Background/aim: To investigate the risk factors for evisceration in a gynecological oncology population. The secondary aim was to evaluate the impact of evisceration on survival. Materials and methods: Inclusion criteria consisted of having had an elective surgery performed through a xiphoidopubic incision in our institution and having a gynecological malignancy based on pathology. A total of 198 patients were evaluated, 54 with evisceration and 144 without evisceration. Due to the widely varied prognosis of female genital cancers, the survival was analyzed on a homogenized group, including only 62 patients with primary advanced stage epithelial ovarian-tubal-peritoneal cancer. Results: The preoperative factors …
Frailty Is Associated With Poor Sleep Quality In The Oldest Old, Çağatay Çavuşoğlu, Olgun Deni̇z, Rana Tuna Doğrul, Süheyla Çöteli̇, Ali̇ Öncül, Muhammet Cemal Kizilarslanoğlu, Berna Göker
Frailty Is Associated With Poor Sleep Quality In The Oldest Old, Çağatay Çavuşoğlu, Olgun Deni̇z, Rana Tuna Doğrul, Süheyla Çöteli̇, Ali̇ Öncül, Muhammet Cemal Kizilarslanoğlu, Berna Göker
Turkish Journal of Medical Sciences
Background/aim: Sleep disorders and frailty increase with advancing age, along with physical disabilities, cognitive dysfunction, mood disorders, and social vulnerability. Thus, the study objective was to evaluate the relationship between frailty and sleep quality in the oldest old patients. Materials and methods: In this study, 100 patients aged ≥ 80 years were assessed using comprehensive geriatric assessment (CGA) including basic activities of daily living (ADL), instrumental ADL, handgrip strength, the Geriatric Depression Scale-15, the MiniMental State Examination, and the Mini-Nutritional Assessment-Short Form. The sleep quality and frailty status of the patients were evaluated using the Pittsburgh Sleep Quality Index (PSQI) …
Interobserver And Intermethod Variability In Data Interpretation Of Breast Strainelastography In Suspicious Breast Lesions, Hale Turnaoğlu, Kemal Murat Haberal, Serdar Arslan, Meri̇ç Yavuz Çolak, Funda Ulu Öztürk, Ni̇hal Uslu
Interobserver And Intermethod Variability In Data Interpretation Of Breast Strainelastography In Suspicious Breast Lesions, Hale Turnaoğlu, Kemal Murat Haberal, Serdar Arslan, Meri̇ç Yavuz Çolak, Funda Ulu Öztürk, Ni̇hal Uslu
Turkish Journal of Medical Sciences
Background/aim: Strain elastography has the disadvantage of being operator-dependent. Interobserver variability is observed during image acquisition and interpretation. This study aimed to analyze the interobserver and intermethod variability of strain elastography in image interpretation and evaluate the diagnostic performance combining elasticity score and strain ratio with ultrasonography. Materials and methods: A retrospective study was conducted on 70 breast lesions evaluated with B-mode ultrasonography and strain elastography. B-mode ultrasonography findings, elasticity scores, and strain ratio values were evaluated using static images by two radiologists. BI-RADS assessment of the lesions and the decision of both observers as to whether the biopsy was …
Early Detection Breast Cancer: Role Of Circulating Plasma Mirna-21 Expression As Apotential Screening Biomarker, Muhammad Noor Diansyah, Ami Ashariati Prayogo, Made Putra Sedana, Merlyna Savitri, Pradana Zaky Romadhon, Putu Niken Ayu Amrita, Andi Yasmin Wijaya, Winona May Hendrata, Ugroseno Yudho Bintoro
Early Detection Breast Cancer: Role Of Circulating Plasma Mirna-21 Expression As Apotential Screening Biomarker, Muhammad Noor Diansyah, Ami Ashariati Prayogo, Made Putra Sedana, Merlyna Savitri, Pradana Zaky Romadhon, Putu Niken Ayu Amrita, Andi Yasmin Wijaya, Winona May Hendrata, Ugroseno Yudho Bintoro
Turkish Journal of Medical Sciences
Aim: To explore the potential of the circulating plasma miRNA-21 as an early detection biomarker by comparing early-stage breast cancer (BG) and healthy control (HG) in Indonesian population. Materials and methods: The enlisted patients were 26 adult female early-stage breast cancer patients (stage 1A, 1B, 2A, and 2B) of Airlangga University Hospital from August 2019 to October 2019. Sixteen volunteers were recruited as matching healthy subjects. MiRNA-21 expression was quantified by plasma qRT-PCR. Data analysis performed using IBM SPSS Statistics v.24 (IBM Corp., Armonk, NY, USA). MiRNA-21 cut-off, sensitivity, and specificity were analyzed using receiver operating characteristic (ROC) curve. Results: …
Role Of Mir-33a, Mir-203b, Mir361-3p, And Mir-424 In Hepatocellular Carcinoma, Burhanetti̇n Yalçinkaya, Esra Güzel Tanoğlu, Di̇dem Taşteki̇n, Sadretti̇n Pençe
Role Of Mir-33a, Mir-203b, Mir361-3p, And Mir-424 In Hepatocellular Carcinoma, Burhanetti̇n Yalçinkaya, Esra Güzel Tanoğlu, Di̇dem Taşteki̇n, Sadretti̇n Pençe
Turkish Journal of Medical Sciences
Background/aim: Hepatocellular carcinoma (HCC) is one of the most aggressive cancer types. MicroRNAs (miRNAs) are small noncoding regulatory RNAs that function posttranscriptionally. miRNA deregulation was observed in the development and progression of HCC. In this study, we aimed to investigate the expression levels of four miRNAs (mir-33a, mir-203b, mir361-3p, and mir-424) in HCC patients in comparison to healthy individuals. Materials and methods: Venous blood samples were collected from both HCC patients and healthy individuals. In order to determine the relative expression levels of mir-33a, mir-203b, mir361-3p, and hsa-mir-424 in HCC patients, probe-based quantitative real time PCR (qRT-PCR) was performed. The …
Basal And Pentagastrin-Stimulated Calcitonin Cut-Off Values In Diagnosis Of Preoperativemedullary Thyroid Cancer, Emi̇ne Kartal Baykan, Mehmet Erdoğan
Basal And Pentagastrin-Stimulated Calcitonin Cut-Off Values In Diagnosis Of Preoperativemedullary Thyroid Cancer, Emi̇ne Kartal Baykan, Mehmet Erdoğan
Turkish Journal of Medical Sciences
Background/aim: Medullary thyroid cancer (MTC) originates from parafollicular cells (C cell) and produces calcitonin (CT). Basal serum CT was used in the diagnosis and treatment of MTC. If basal CT level is 100 pg/mL or higher, it is likely to have MTC, but if basal CT level is below 10 pg/mL, the probability of developing thyroid disease is low. In cases with basal CT level between 10-100 pg/mL, pentagastrin-stimulated (PS) CT level is studied to evaluate MTC and C cell hyperplasia (CHH). This study aimed to determine cut-off value for basal and PS peak CT level for diagnosis of MTC. …
Evaluation Of Saliva Glutathione, Glutathione Peroxidase, And Malondialdehyde Levels Inhead-Neck Radiotherapy Patients, Gözde Deri̇ndağ, Hayati̇ Murat Akgül, Ahmet Kiziltunç, Hali̇l İbrahi̇m Özkan, Hi̇lal Kiziltunç Özmen, Ni̇lgün Akgül
Evaluation Of Saliva Glutathione, Glutathione Peroxidase, And Malondialdehyde Levels Inhead-Neck Radiotherapy Patients, Gözde Deri̇ndağ, Hayati̇ Murat Akgül, Ahmet Kiziltunç, Hali̇l İbrahi̇m Özkan, Hi̇lal Kiziltunç Özmen, Ni̇lgün Akgül
Turkish Journal of Medical Sciences
Background/aim: It is believed that radiotherapy has important effects on oxidant/antioxidant systems. Oxidative stress occurs when the balance between oxidant formation and antioxidant defense is disrupted in favor of oxidants. The aim of this study was to determine the biochemical changes in saliva pre- and postradiotherapy in head-neck radiotherapy patients and to find out the effects of radiation on glutathione (GSH), glutathione peroxidase (GSH-Px), and malondialdehyde (MDA) levels in saliva. Materials and methods: This study included 16 patients undergoing head-neck radiotherapy in Atatürk University Research Hospital. The levels of GSH, GSH-Px, and MDA were measured in saliva samples taken from …
Evaluation Of The Results Of Patients Who Applied To The Çukurova University, Medicalgenetics Department For Prenatal Diagnosis And Determination Of Genetic Counselingprinciples, Sevcan Tuğ Bozdoğan, Seli̇m Büyükkurt, Si̇nem Özer, Atil Bi̇şgi̇n
Evaluation Of The Results Of Patients Who Applied To The Çukurova University, Medicalgenetics Department For Prenatal Diagnosis And Determination Of Genetic Counselingprinciples, Sevcan Tuğ Bozdoğan, Seli̇m Büyükkurt, Si̇nem Özer, Atil Bi̇şgi̇n
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to summarize the experiences of a single medical center for genetic diagnosis and treatment of prenatal patients. Materials and methods: This study includes a retrospective data analysis of 2843 prenatally investigated cases using invasive methods during a 6-year period (2013-2019) at a single tertiary care center. Results: Chromosomal abnormalities were detected in 80 out of 1221 amniotic fluid samples;,178 out of 1608 chorionic villus samples, and 1 out of 14 cordocentesis samples. The most common chromosomal abnormality was trisomy 21. At least one mutation was detected in 63 of the 152 molecular tests …
Investigation Of The Expression Levels Of Cpeb4, Apc, Trip13, Eif2s3, Eif4a1, Ifng,Pik3ca And Ctnnb1 Genes In Different Stage Colorectal Tumors, Zafer Söylemez, Evri̇m Suna Arikan, Mustafa Solak, Yüksel Arikan, Çi̇ğdem Tokyol, Hüseyi̇n Şeker
Investigation Of The Expression Levels Of Cpeb4, Apc, Trip13, Eif2s3, Eif4a1, Ifng,Pik3ca And Ctnnb1 Genes In Different Stage Colorectal Tumors, Zafer Söylemez, Evri̇m Suna Arikan, Mustafa Solak, Yüksel Arikan, Çi̇ğdem Tokyol, Hüseyi̇n Şeker
Turkish Journal of Medical Sciences
Background/aim: The aim of the study is to assess expression levels of CPEB4, APC, TRIP13, EIF2S3, EIF4A1, IFNg, PIK3CA and CTNNB1 genes in tumors and peripheral bloods of colorectal cancer patients in stages I-IV. Materials and methods: The mRNA levels of the genes were determined in tumor tissues and peripheral blood samples of 45 colorectal cancer patients and colon tissues and peripheral blood samples of 5 healthy individuals. Real-time polymerase chain reaction method was used for the analysis. Results: The mRNA level of the CPEB4 gene was significantly downregulated in colorectal tumor tissues and was upregulated in the peripheral blood …
Assessment And Prevalence Of Concomitant Chemo-Radiotherapy-Induced Oral Mucositisin Patients With Oral Squamous Cell Carcinoma, Sadia Minhas, Aneequa Sajjad, Rabia Chaudhry, Hamza Zahid, Azfar Shahid, Muhammad Kashif
Assessment And Prevalence Of Concomitant Chemo-Radiotherapy-Induced Oral Mucositisin Patients With Oral Squamous Cell Carcinoma, Sadia Minhas, Aneequa Sajjad, Rabia Chaudhry, Hamza Zahid, Azfar Shahid, Muhammad Kashif
Turkish Journal of Medical Sciences
Background/aim: Quantification of oral mucositis that progresses during concomitant chemo-radiotherapy (CCRT) is essential for its management. It is important to determine the methods that are simple, reliable and beneficial in foreseeing mucositis at earlier stages of treatment. Materials and methods: A prospective study was conducted on 100 oral cancer patients receiving CCRT following the inclusion criteria. Patients were evaluated for mucositis i.e. erythema and ulcers by using the World Health Organization (WHO) scale and the oral mucositis assessment scale (OMAS), whereas mature and immature cells were identified by exfoliative cytology. Clinical examination and procedure of oral cavity were performed before, …
Gemcitabine, Dexamethasone And Cisplatin (Gdp) Is An Effective And Well-Toleratedmobilization Regimen For Relapsed And Refractory Lymphoma: A Single Center Experience, Hi̇kmettullah Batgi̇, Semi̇h Başci, Mehmet Si̇nan Dal, Meri̇h Kizil Çakar, Bahar Uncu Ulu, Tuğçe Nur Yi̇ğenoğlu, Nurgül Özcan, Ali̇ Kilinç, Alparslan Merdi̇n, Jale Yildiz, Mehmet Bakirtaş, Derya Şahi̇n, Tahi̇r Darçin, Di̇cle İskender, Nuran Ahü Baysal
Gemcitabine, Dexamethasone And Cisplatin (Gdp) Is An Effective And Well-Toleratedmobilization Regimen For Relapsed And Refractory Lymphoma: A Single Center Experience, Hi̇kmettullah Batgi̇, Semi̇h Başci, Mehmet Si̇nan Dal, Meri̇h Kizil Çakar, Bahar Uncu Ulu, Tuğçe Nur Yi̇ğenoğlu, Nurgül Özcan, Ali̇ Kilinç, Alparslan Merdi̇n, Jale Yildiz, Mehmet Bakirtaş, Derya Şahi̇n, Tahi̇r Darçin, Di̇cle İskender, Nuran Ahü Baysal
Turkish Journal of Medical Sciences
Background/aim: Gemcitabine, dexamethasone and cisplatin (GDP) is a well-established salvage regimen for relapsed and refractory lymphomas. In this study, we aimed to share our experience with the patients who received GDP/R-GDP (rituximab-gemcitabine, dexamethasone and cisplatin) for stem cell mobilization. Materials and methods: Data of 69 relapsed and refractory Hodgkin lymphoma (HL) and Non-Hodgkin lymphoma (NHL) patients who received GDP/R-GDP as salvage chemotherapy in our center between July 2014 and January 2020 were retrospectively evaluated. After the evaluation of response, 52 patients had a chemosensitive disease and underwent mobilization with GDP/R-GDP plus G-CSF (granulocyte colony-stimulating factor). Collected CD34+ stem cells and …
The Platelet To Lymphocyte Ratio Predicts Overall Survival Better Than The Neutrophil Tolymphocyte Ratio In Metastatic Renal Cell Carcinoma, Oktay Hali̇t Aktepe, Gürkan Güner, Deni̇z Can Güven, Taha Koray Şahi̇n, Fadi̇me Si̇nem Ardiç, Deni̇z Yüce, Şuayi̇b Yalçin, Mustafa Erman
The Platelet To Lymphocyte Ratio Predicts Overall Survival Better Than The Neutrophil Tolymphocyte Ratio In Metastatic Renal Cell Carcinoma, Oktay Hali̇t Aktepe, Gürkan Güner, Deni̇z Can Güven, Taha Koray Şahi̇n, Fadi̇me Si̇nem Ardiç, Deni̇z Yüce, Şuayi̇b Yalçin, Mustafa Erman
Turkish Journal of Medical Sciences
Background/aim: The prognostic values of systemic inflammatory markers, neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR) on overall survival (OS) of metastatic renal cell carcinoma patients (mRCC) treated with tyrosine kinase inhibitors (TKI) remain unclear. Thus, the present study aimed to investigate the prognostic impact of these markers on OS of mRCC patients. Materials and methods: A total of 150 patients receiving TKIs were retrospectively analyzed. Progression-free survival and OS times were analyzed with the Kaplan-Meier method, and the log-rank test was used for comparison. Univariable and multivariable Cox regression models evaluated the impact of NLR and …
Demographic And Clinical Characteristics Of Children With Autosomal Dominantpolycystic Kidney Disease: A Single Center Experience, Belde Kasap Demi̇r, Fatma Mutlubaş, Eren Soyaltin, Caner Alparslan, Merve Arya, Demet Eğlenoğlu Alaygut, Seçi̇l Arslansoyu Çamlar, Afi̇g Berdeli̇, Önder Yavaşcan
Demographic And Clinical Characteristics Of Children With Autosomal Dominantpolycystic Kidney Disease: A Single Center Experience, Belde Kasap Demi̇r, Fatma Mutlubaş, Eren Soyaltin, Caner Alparslan, Merve Arya, Demet Eğlenoğlu Alaygut, Seçi̇l Arslansoyu Çamlar, Afi̇g Berdeli̇, Önder Yavaşcan
Turkish Journal of Medical Sciences
Background/aim: In children with autosomal dominant polycystic kidney disease (ADPKD), clinical manifestations range from severe neonatal presentation to renal cysts found by chance. We aimed to evaluate demographic, clinical, laboratory findings, and genetic analysis of children with ADPKD. Materials and methods: We evaluated children diagnosed with ADPKD between January 2006 and January 2019. The diagnosis was established by family history, ultrasound findings, and/or genetic analysis. The demographic, clinical, and laboratory findings were evaluated retrospectively. Patients
Evaluation Of The Relationship Between Shear Wave Elastography Measurements Withlaboratory And Doppler Us Parameters In Patients With Adult Hashimoto's Thyroiditis, Nurten Andaç Baltacioğlu, Ferhan Mantar, Efe Soydemi̇r
Evaluation Of The Relationship Between Shear Wave Elastography Measurements Withlaboratory And Doppler Us Parameters In Patients With Adult Hashimoto's Thyroiditis, Nurten Andaç Baltacioğlu, Ferhan Mantar, Efe Soydemi̇r
Turkish Journal of Medical Sciences
Background/aim: Hashimoto thyroiditis (HT) is an autoimmune disease that leads to tissue stiffening secondary to lymphocyte infiltration of the thyroid gland. Gray-scale ultrasound (US) is widely used in its diagnosis. Numerous studies have been conducted comparing elastography findings of HT with tissue stiffness and immunoreactivity levels. This study aims to reveal the relationship between shear wave elastography (SWE) and Doppler parameters in patients with HT. Materials and methods: The study group consisted of 45 patients diagnosed with HT, and 20 control patients without thyroid pathology. Thyroid-stimulating hormone (TSH) and antithyroid peroxidase (TPO) values were examined in patients with HT. Thyroid …
Transient Receptor Potential Melastatin 2 Ion Channel Activity In Ovarianhyperstimulation Syndrome Physiopathology, Cengi̇z Şanli, Remzi̇ Atilgan, Tuncay Kuloğlu, Şehmus Pala, Bi̇lge Aydin Türk, Hasan Burak Keser, Nevi̇n İlhan
Transient Receptor Potential Melastatin 2 Ion Channel Activity In Ovarianhyperstimulation Syndrome Physiopathology, Cengi̇z Şanli, Remzi̇ Atilgan, Tuncay Kuloğlu, Şehmus Pala, Bi̇lge Aydin Türk, Hasan Burak Keser, Nevi̇n İlhan
Turkish Journal of Medical Sciences
Background/aim: Ovarian hyperstimulation syndrome (OHSS) is a complication of ovarian stimulation with increased vascular endothelial growth factor (VEGF) and vascular permeability in the ovarian tissue. Transient receptor potential melastatin 2 (TRPM2) is known to be associated with angiogenesis and vascular permeability. In this experimental study, we aimed to investigate the activity of TRPM2 in the development of OHSS. Materials and methods: Fourteen immature female rats were divided into two groups. Group 1 was the control group, and Group 2 was the OHSS group that was exposed to 10 IU of subcutaneous application of FSH for four days and 30 IU …
Vitamin D Receptor Polymorphisms And Bone Health After Kidney Transplantation, Berfu Korucu, Fatma Ajlan Tükün, Özant Helvaci, Haci Hasan Yeter, Sevi̇m Gönen, Gali̇p Güz, Seli̇m Turgay Arinsoy
Vitamin D Receptor Polymorphisms And Bone Health After Kidney Transplantation, Berfu Korucu, Fatma Ajlan Tükün, Özant Helvaci, Haci Hasan Yeter, Sevi̇m Gönen, Gali̇p Güz, Seli̇m Turgay Arinsoy
Turkish Journal of Medical Sciences
Background/aim: Bone disease is one of the most prominent complications after kidney transplantation. Bone diseases include osteoporosis, persistent secondary hyperparathyroidism, and avascular necrosis (AVN). We investigated the relationship between the polymorphisms of the vitamin D receptor (VDR) gene and bone diseases occurring after kidney transplantation. Materials and methods: The study consists of 234 kidney allograft recipients with a minimum follow-up of five years after kidney transplantation. Patients with glomerular filtration rates less than 30 mL/min/1.73m2 , a history of parathyroidectomy, bisphosphonate use pre- or post-transplantation, and cinacalcet use posttransplantation excluded. We evaluated associations between the polymorphisms of the VDR gene …
Reliability And Validity Of The Turkish Version Of The Vestibular Rehabilitation Benefitquestionnaire, Bülent Gündüz, Yasemi̇n Apaydin, Arzu Güçlü Gündüz, Burak Kabi̇ş, Hakan Tutar
Reliability And Validity Of The Turkish Version Of The Vestibular Rehabilitation Benefitquestionnaire, Bülent Gündüz, Yasemi̇n Apaydin, Arzu Güçlü Gündüz, Burak Kabi̇ş, Hakan Tutar
Turkish Journal of Medical Sciences
Background/aims: Vestibular rehabilitation has an important role in the reduction of symptoms and in the recovery of patients in peripheral vestibular pathologies. Objective and subjective vestibular assessment tools are needed to assess vestibular rehabilitation effectiveness. The aims of the study were to develop the Turkish version of the internationally used Vestibular Rehabilitation Benefit Questionnaire (VRBQ) measure and to demonstrate the reliability and validity properties of the Turkish version in patients with peripheral vestibular hypofunction (PVH). Materials and methods: 110 patients with unilateral PVH were included. For the analysis of test-retest reliability, Turkish version of VRBQ developed by translation-back translation method …
Metformin Promotes Apoptosis In Primary Breast Cancer Cells By Downregulation Ofcyclin D1 And Upregulation Of P53 Through An Ampk-Alpha Independent Mechanism, Güven Yenmi̇ş, Nai̇l Beşli̇, Eli̇f Yaprak Saraç, Fatma Si̇nem Hocaoğlu Emre, Kazim Şenol, Gönül Kanigür
Metformin Promotes Apoptosis In Primary Breast Cancer Cells By Downregulation Ofcyclin D1 And Upregulation Of P53 Through An Ampk-Alpha Independent Mechanism, Güven Yenmi̇ş, Nai̇l Beşli̇, Eli̇f Yaprak Saraç, Fatma Si̇nem Hocaoğlu Emre, Kazim Şenol, Gönül Kanigür
Turkish Journal of Medical Sciences
Background/aim: In the present study we aimed to figure out the effect of metformin on the expression of AMPK-alpha, cyclin D1, and Tp53, and apoptosis in primary breast cancer cells (PBCCs). Materials and methods: PBCCs were treated with two doses of metformin (0 mM, 25 mM). Proliferation was determined by BrdU assay. Real-time PCR was used to assess AMPK-alpha, cyclin D1, and Tp53 gene expressions; apoptotic indexes of PBCCs were analyzed using flow-cytometry. Results: Twenty-four-hour incubation with 25 mM metformin reduced the proliferation of PBCCs. AMPK-alpha gene expression in PBCCs was not affected by 25 mM metformin treatment compared with …
Nonsteroidal Antiinflammatory Drugs Alter Antibiotic Susceptibility And Expression Ofvirulence-Related Genes And Protein A Of Staphylococcus Aureus, İsmai̇l Öztürk, Yasemi̇n Eraç, Petek Ballar Kirmizibayrak, Şafak Ermertcan
Nonsteroidal Antiinflammatory Drugs Alter Antibiotic Susceptibility And Expression Ofvirulence-Related Genes And Protein A Of Staphylococcus Aureus, İsmai̇l Öztürk, Yasemi̇n Eraç, Petek Ballar Kirmizibayrak, Şafak Ermertcan
Turkish Journal of Medical Sciences
Background/aim: Nonsteroidal antiinflammatory drugs (NSAIDs) including diclofenac, naproxen, ibuprofen, acetylsalicylic acid, and acetaminophen have been shown to have antimicrobial effects on various microorganisms. The aim of this study was to investigate the antibacterial effects of NSAIDs on Staphylococcus aureus. Materials and methods: Susceptibilities of S. aureus strains to NSAIDs with or without antimicrobials (moxifloxacin, vancomycin, ciprofloxacin, clindamycin, and gentamicin) were determined using the microdilution method and disk diffusion test. Expression levels of genes in the presence of drugs were investigated by real-time quantitative RT-PCR (qRT-PCR), and immunoblotting analysis was performed for staphylococcal protein A (SpA). Results: Our results showed that …
The Effect Of Caffeic Acid Phenethyl Ester And Ankaferd Blood Stopper On The Diabetic Andnondiabetic Gingival Wound Healing: An Experimental Study, Mehmet Gül, Serkan Dündar, Gökhan Artaş, Akin Yi̇ği̇n, Abdulsamet Tanik, Mehmet Emrah Polat, Erhan Cahi̇t Özcan
The Effect Of Caffeic Acid Phenethyl Ester And Ankaferd Blood Stopper On The Diabetic Andnondiabetic Gingival Wound Healing: An Experimental Study, Mehmet Gül, Serkan Dündar, Gökhan Artaş, Akin Yi̇ği̇n, Abdulsamet Tanik, Mehmet Emrah Polat, Erhan Cahi̇t Özcan
Turkish Journal of Medical Sciences
Background/aim: Healthy wound healing is very important for patient comfort. Diabetes is one of the factors that negatively affect wound healing. Ankaferd Blood Stopper (ABS) and caffeic acid phenethyl ester (CAPE) are antiinflammatory and antimicrobial agents and may have positive effects on wound healing. Materials and methods: In this study, 72 male Wistar albino rats were used. Rats; control, CAPE, ABS, diabetes + control, diabetes + ABS and diabetes + CAPE groups were divided into 6 groups. A healthy 36 rats created diabetes using streptozotocin (STZ). A gingival wound was created using a 4-mm punch biopsy in the gingival tissue …
Effects Of Sitagliptin On Ss-Adrenoceptor Mediated Relaxation In Streptozotocin-Diabeticrat Aorta, Ayhanim Eli̇f Müderri̇soğlu, Betül Rabi̇a Erdoğan, Zeynep Eli̇f Yeşi̇lyurt, Ceren Uyar Boztaş, İrem Karaömerli̇oğlu, Vecdi̇ Meli̇h Altan, Ebru Arioğlu İnan
Effects Of Sitagliptin On Ss-Adrenoceptor Mediated Relaxation In Streptozotocin-Diabeticrat Aorta, Ayhanim Eli̇f Müderri̇soğlu, Betül Rabi̇a Erdoğan, Zeynep Eli̇f Yeşi̇lyurt, Ceren Uyar Boztaş, İrem Karaömerli̇oğlu, Vecdi̇ Meli̇h Altan, Ebru Arioğlu İnan
Turkish Journal of Medical Sciences
Background/aim: Dipeptidyl peptidase-4 (DPP4) inhibitors, a class of oral antidiabetic drugs, have been shown to be protective on the vascular system because of their antiinflammatory, antiatherosclerotic, and vasodilatory effects. ß2 -adrenoceptors (ß2 -ARs) mediate the vasorelaxation in the aorta. However, ß3 -adrenoceptor-mediated relaxation has not been studied in diabetic aorta yet. Thus, we aimed to study the effect of sitagliptin treatment on ß2 - and ß3 -adrenoceptor-mediated relaxations in the diabetic rat aorta. Materials and methods: Eight-week old Sprague Dawley rats were divided into three groups: control, diabetic, sitagliptin treated diabetic. Diabetes was induced by injection of streptozotocin (35 or …
Covid-19 Transmission Sources, Management, And Scientific Research In Turkey, Fati̇h Kahraman, Adem Özkara
Covid-19 Transmission Sources, Management, And Scientific Research In Turkey, Fati̇h Kahraman, Adem Özkara
Turkish Journal of Medical Sciences
No abstract provided.
Maternal Hpa Axis Function During Parenting Is Associated With Reduced Brain Activation To Infant Cry And More Intrusive Parenting Behavior, Andrew Erhart
Electronic Theses and Dissertations
Previous research indicated that maternal cortisol function and maternal brain response to infant stimuli are separately related to differences in parenting behavior. Evidence from animal models have demonstrated that chronically high cortisol concentration alters brain structure and function, suggesting that studying these two mechanisms together may further improve understanding of parental behavior in human mothers. First time mothers of infants aged 1-7 months old (M age = 3 months) were recruited to participate. Mother’s cortisol concentration was measured during a naturalistic interaction with their infant and their behavior was coded for maternal sensitivity and nonintrusiveness. In a separate session using …
Structure And Activity Of A Selective Antibiofilm Peptide Sk-24 Derived From The Nmr Structure Of Human Cathelicidin Ll-37, Yingxia Zhang, Jayaram Lakshmaiah Narayana, Qianhui Wu, Xiangli Dang, Guangshun Wang
Structure And Activity Of A Selective Antibiofilm Peptide Sk-24 Derived From The Nmr Structure Of Human Cathelicidin Ll-37, Yingxia Zhang, Jayaram Lakshmaiah Narayana, Qianhui Wu, Xiangli Dang, Guangshun Wang
Journal Articles: Pathology and Microbiology
The deployment of the innate immune system in humans is essential to protect us from infection. Human cathelicidin LL-37 is a linear host defense peptide with both antimicrobial and immune modulatory properties. Despite years of studies of numerous peptides, SK-24, corresponding to the long hydrophobic domain (residues 9–32) in the anionic lipid-bound NMR structure of LL-37, has not been investigated. This study reports the structure and activity of SK-24. Interestingly, SK-24 is entirely helical (~100%) in phosphate buffer (PBS), more than LL-37 (84%), GI-20 (75%), and GF-17 (33%), while RI-10 and 17BIPHE2 are essentially randomly coiled (helix%: 7–10%). These results …
Targeting Epigenetic Mechanisms In Endometriosis, Sarah Elizabeth Brunty
Targeting Epigenetic Mechanisms In Endometriosis, Sarah Elizabeth Brunty
Theses, Dissertations and Capstones
Endometriosis is a complex and elusive gynecological disease in which the inner lining of the uterus grows in locations outside of the uterus and forms lesions. It is known to affect 1 in 9 women of reproductive age worldwide. Symptoms of endometriosis include severe pain, heavy periods, and infertility. While multiple theories of origin exist, none fully encompass all aspects of the disease, although all theories agree that this is an inflammation-driven disease. Due to this, many researchers are turning towards epigenetics to explain the initiation and progression of endometriosis. However, what is causing these epigenetic changes is still a …
Role Of Dyslipidemia In Early Vascular Aging Syndrome, Alparslan Kiliç, Onur Baydar, Deni̇z Elçi̇k, Zi̇ya Apaydin, Mehmet Mustafa Can
Role Of Dyslipidemia In Early Vascular Aging Syndrome, Alparslan Kiliç, Onur Baydar, Deni̇z Elçi̇k, Zi̇ya Apaydin, Mehmet Mustafa Can
Turkish Journal of Medical Sciences
Background/aim: Arterial stiffness, known as a predictor of early vascular aging, was defined as the main determinant of cardiovascular mortality and morbidity. However, the relationship between lipid profile and increased arterial stiffness is not clear. The aim of this study is to investigate the relationship between lipid profiles and increased arterial stiffness in patients with early vascular aging syndrome. Materials and methods: A total of 1582 participants -504 (31.8%) of were male and the mean age was 52.8 ±14.2 years' were included in the study . Patients who applied to the hospital for various reasons and who had undergone 24-h …