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Rapid Differentiation Of Moraxella Bovoculi Genotypes 1 And 2 Using Maldi-Tof Mass Spectrometry Profiles, Matthew M. Hille, Aaron M. Dickey, Kara Robbins, Michael L. Clawson, John Dustin Loy Jan 2020

Rapid Differentiation Of Moraxella Bovoculi Genotypes 1 And 2 Using Maldi-Tof Mass Spectrometry Profiles, Matthew M. Hille, Aaron M. Dickey, Kara Robbins, Michael L. Clawson, John Dustin Loy

School of Veterinary and Biomedical Sciences: Faculty Publications

Moraxella bovoculi is the most frequently isolated bacteria from the eyes of cattle with Infectious Bovine Keratoconjunctivitis (IBK), also known as bovine pinkeye. Two distinct genotypes of M. bovoculi, genotype 1 and genotype 2, were characterized after whole genome sequencing showed a large degree of single nucleotide polymorphism (SNP) diversity within the species. To date, both genotypes have been isolated from the eyes of cattle without clinical signs of IBK while only genotype 1 strains have been isolated from the eyes of cattle with clinical signs of IBK. We used 38 known genotype 1 strains and 26 known genotype …

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Tick-Borne Infections In New Hampshire: An Evaluation Of The Diagnostic Process In A Local Patient Population, Katherine Anderson Jan 2020

Tick-Borne Infections In New Hampshire: An Evaluation Of The Diagnostic Process In A Local Patient Population, Katherine Anderson

Honors Theses and Capstones

Overall, approximately 95 percent of reported cases of vector-borne disease were associated with ticks, making these the most medically important group of arthropods in the United States.1 Despite the prevalence of tick-borne infections, the process for the diagnosis of this condition is not well studied. This study aims to analyze data from a pool of 100 patients who underwent testing for tick-borne disease in the same institution in Dover, New Hampshire during the most recent peak tick season of 2019. Information utilized in this study included: patient age, sex, location of testing (inpatient versus outpatient), diagnostic testing methods used …

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Efficacy Of Hijamat (Wet Cupping Therapy) In Iranian Patients With Nonalcoholic Fattyliver Disease: A Controlled Clinical Trial, Homayoon Bashiri, Arezoo Bozorgomid, Vahid Shojaeimotlagh Jan 2020

Efficacy Of Hijamat (Wet Cupping Therapy) In Iranian Patients With Nonalcoholic Fattyliver Disease: A Controlled Clinical Trial, Homayoon Bashiri, Arezoo Bozorgomid, Vahid Shojaeimotlagh

Turkish Journal of Medical Sciences

Background/aim: Nonalcoholic fatty liver disease (NAFLD) is known to be the most prevalent chronic liver disease all over the world. The incidence of this disease has dramatically increased during the last decade. Studies have shown a strong relationship between the level of ferritin and the severity of NAFLD. The objective of the present study was to assess the effect of adding Hijamat, as an iron reducing procedure, to standard lifestyle modification on the improvement of insulin resistance and liver enzymes in patients with NAFLD. Materials and methods: One hundred and twenty NAFLD patients participated in a randomized, controlled, single-blind trial …

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The Effects Of Blood Group Types On The Risk Of Covid-19 Infection And Its Clinical Outcome, Hakan Göker, Eli̇fcan Aladağ Karakulak, Haluk Demi̇roğlu, Çağlayan Merve Ayaz Ceylan, Yahya Büyükaşik, Ahmet Çağkan İnkaya, Salih Aksu, Ni̇lgün Sayinalp, İbrahi̇m Celaletti̇n Haznedaroğlu, Ömrüm Uzun, Murat Akova, Osman İlhami̇ Özcebe, Serhat Ünal Jan 2020

The Effects Of Blood Group Types On The Risk Of Covid-19 Infection And Its Clinical Outcome, Hakan Göker, Eli̇fcan Aladağ Karakulak, Haluk Demi̇roğlu, Çağlayan Merve Ayaz Ceylan, Yahya Büyükaşik, Ahmet Çağkan İnkaya, Salih Aksu, Ni̇lgün Sayinalp, İbrahi̇m Celaletti̇n Haznedaroğlu, Ömrüm Uzun, Murat Akova, Osman İlhami̇ Özcebe, Serhat Ünal

Turkish Journal of Medical Sciences

Background/aim: COVID-19 (Coronavirus disease of 2019) is an infectious disease outbreak later on declared as a pandemic, caused by the SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2). It spreads very rapidly and can result in severe acute respiratory failure. The clinical studies have shown that advanced age and chronic diseases increase the risk of infection. However, influence of the blood groups on COVID-19 infection and its outcome remains to be confirmed. The aim of this study is to investigate whether there exists a relationship between the blood groups of the patients and risk of SARS-CoV-2 infection and the clinical outcomes in …

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Factors Associated With Severe Lung Disease In An Adult Population With Cystic Fibrosis: A Single-Center Experience, Berri̇n Er, Ebru Çelebi̇oğlu, Ebru Yalçin, Deni̇z Doğru, Özlem Erden Aki̇, Ömrüm Uzun, Murat Akova, Uğur Özçeli̇k, Nural Ki̇per, Sali̇h Emri̇ Jan 2020

Factors Associated With Severe Lung Disease In An Adult Population With Cystic Fibrosis: A Single-Center Experience, Berri̇n Er, Ebru Çelebi̇oğlu, Ebru Yalçin, Deni̇z Doğru, Özlem Erden Aki̇, Ömrüm Uzun, Murat Akova, Uğur Özçeli̇k, Nural Ki̇per, Sali̇h Emri̇

Turkish Journal of Medical Sciences

Background/Aim: The patients with cystic fibrosis (CF) are living longer compared to the past, but respiratory failure is still the most common cause of mortality. The aim of this study is to investigate factors associated with severe lung disease in a cohort of adult patients with CF. Materials and methods: Demographic data, clinical and laboratory findings of the patients aged 18 years and more were collected and the patients were grouped according to forced expiratory volume in 1 s (FEV1) as severe group:

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Risk Indices That Predict In-Hospital Mortality Of Elderly Patients, Di̇lek Dülger, Özgür Albuz Jan 2020

Risk Indices That Predict In-Hospital Mortality Of Elderly Patients, Di̇lek Dülger, Özgür Albuz

Turkish Journal of Medical Sciences

Background/aim: Mortality in the elderly population tends to be higher than in all other age groups; the risk factors that predict mortality among those in this age cohort are not fully understood. This large-scale clinical study aimed to identify effective risk factors that predict mortality in the elderly population with a particular focus on age and hospitalization status. Material and methods: We retrospectively analyzed outcomes from patients with clinical follow-up between July 2015 and January 2020 at 29 Mayıs State Hospital, Ankara, Turkey. Patient records with missing or ambiguous data were excluded. Age, sex, length of hospital stay, comorbidities, consultation …

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Evaluation Of The Effects Of Ss1-Selective Beta-Blockers On Bone Mineral Density And Fracture Risk In Postmenopausal Women, Betül Yavuz Keleş, Meltem Vural, Burcu Önder, Kadri̇ye Öneş Jan 2020

Evaluation Of The Effects Of Ss1-Selective Beta-Blockers On Bone Mineral Density And Fracture Risk In Postmenopausal Women, Betül Yavuz Keleş, Meltem Vural, Burcu Önder, Kadri̇ye Öneş

Turkish Journal of Medical Sciences

Background/aim: ß1-selective beta-blockers (BBs) are sympatholytic agents, and discerning their effects on bone health would be of great importance. This study aimed to investigate the influence of ß1-selective BBs on bone mineral density (BMD) and fracture risk. Materials and methods: This study included postmenopausal women who used ß1-selective BBs (BB group) and control group. Sociodemographic characteristics, BMD and previous fragility fractures were recorded. Additionally, the 10-year probability of a major osteoporotic and hip fracture was calculated using the fracture risk assessment tool (FRAX). Results: A total of 60 participants were included in the study. L1-4 and L2-4 BMD values were …

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Evaluation Of The Cardioprotective Effects Of Crystalloid Del Nido Cardioplegia Solution Via A Rapid And Accurate Cardiac Marker: Heart-Type Fatty Acid-Binding Protein, Mehmet Ki̇ri̇şci̇, Aydemi̇r Koçarslan, Duygun Altintaş Aykan, Fi̇li̇z Alkan Baylan, Adem Doğaner, Yavuz Orak Jan 2020

Evaluation Of The Cardioprotective Effects Of Crystalloid Del Nido Cardioplegia Solution Via A Rapid And Accurate Cardiac Marker: Heart-Type Fatty Acid-Binding Protein, Mehmet Ki̇ri̇şci̇, Aydemi̇r Koçarslan, Duygun Altintaş Aykan, Fi̇li̇z Alkan Baylan, Adem Doğaner, Yavuz Orak

Turkish Journal of Medical Sciences

Background/aim: Our aim in this study was to compare the efficacy and safety of crystalloid del Nido solution and cold blood cardioplegia solution on clinical and laboratory parameters. Materials and methods: Sixty patients who underwent elective coronary bypass operation between July 2019 and January 2020 were included in our study. Patients were divided into 2 groups of 30 patients using del Nido solution (DNS) and cold blood cardioplegia solution (CBCS), which were given for cardiac arrest. Demographic data, preoperative, postoperative 0th h, 6th h and 4th day creatine kinase myocardial band (CK-MB) and troponin I values were compared with a …

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Ocular Toxicity Of Intravitreal Golimumab In A Rabbit Model, Ceren Durmaz Engi̇n, Serap Ci̇laker Miçili, Osman Yilmaz, Hüsnü Alper Bağriyanik, Beki̇r Uğur Ergür, Fatoş Önen, Ali̇ Osman Saatci̇ Jan 2020

Ocular Toxicity Of Intravitreal Golimumab In A Rabbit Model, Ceren Durmaz Engi̇n, Serap Ci̇laker Miçili, Osman Yilmaz, Hüsnü Alper Bağriyanik, Beki̇r Uğur Ergür, Fatoş Önen, Ali̇ Osman Saatci̇

Turkish Journal of Medical Sciences

Background/aim: To investigate the effect of intravitreal golimumab on rabbit retina histopathology. Materials and methods: Sixteen albino New Zealand rabbits were divided into three groups. The right eye of each rabbit in groups I, II, and III received a single intravitreal injection of 5 mg/0.05 mL (6 eyes), 10 mg/0.1 mL (6 eyes), or 20 mg/0.2 mL (4 eyes) golimumab, while left eyes served as controls with the same volume of a balanced salt solution injection. All animals were examined using slit-lamp biomicroscopy and indirect ophthalmoscopy before and after intravitreal injection and at days 1 and 7. Animals were euthanized …

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Alcohol Consumption And Alcohol Policy, Mustafa Necmi̇ İlhan, Di̇lek Yapar Jan 2020

Alcohol Consumption And Alcohol Policy, Mustafa Necmi̇ İlhan, Di̇lek Yapar

Turkish Journal of Medical Sciences

Alcohol is a unique addictive substance used by many people for different reasons. Alcohol use affects not only the users but also the family and the whole society in a negative way. Alcohol is one of the most commonly used substances for entertainment purposes in the world and 1 in 3 people is a current drinker. 2348 billion people (43% of the population) aged 15 and over are current drinkers and males drink about 2 times more frequently than females (53.6%/32.3%). According to the Global Alcohol and Health Report published by the World Health Organization (WHO) (2018), total alcohol per …

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Oxidative Stress Parameters In Patients With Ascending Aortic Dilatation, Mehmet Erdoğan, Meli̇ke Polat, Muhammet Ci̇hat Çeli̇k, Selçuk Öztürk, Serdal Baştuğ, Yunus Emre Özbebek, Sali̇m Neşeli̇oğlu, Murat Akçay Jan 2020

Oxidative Stress Parameters In Patients With Ascending Aortic Dilatation, Mehmet Erdoğan, Meli̇ke Polat, Muhammet Ci̇hat Çeli̇k, Selçuk Öztürk, Serdal Baştuğ, Yunus Emre Özbebek, Sali̇m Neşeli̇oğlu, Murat Akçay

Turkish Journal of Medical Sciences

Background/aim: This study aimedto determine plasma thiol, disulphide, and serum ischemia-modified albumin (IMA) levels and ferroxidase activity in patients with ascending aorta dilatation (AAD) in comparison to those without AAD and to evaluate the predictive value of these oxidative stress parameters for AAD.Materials and methods: This study was designed as a cross-sectional study of 184 patients who applied to our cardiology clinic. Our study population consisted of patients with AAD (n = 85) and without AAD (n = 99). A spectrophotometric method was used to determine plasma thiol, disulphide, and serum IMA levels and ferroxidase activity.Results: The native thiol and …

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He Utility Of Synovial Fluid Levels Of Adamts9 And Adamts4 In Predicting Treatment Responses To Intraarticular Steroid Injections In Patients With Knee Osteoarthritis, Kenan Özler Jan 2020

He Utility Of Synovial Fluid Levels Of Adamts9 And Adamts4 In Predicting Treatment Responses To Intraarticular Steroid Injections In Patients With Knee Osteoarthritis, Kenan Özler

Turkish Journal of Medical Sciences

Background/aim: This study aims to identify the role of synovial fluid levels of a disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9) and a disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4) for the prediction of intraarticular steroid injection success in knee osteoarthritis (OA).Material and methods: A total of eighty-four advanced stage knee OA patients (42 with stage 3 OA and 42 with stage 4 OA) were enrolled in the study. Baseline and posttreatment outcomes were determined using Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Pretreatment synovial fluid ADAMTS9 and ADAMTS4 levels were measured by enzyme linked immunosorbent assay …

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Determination Of Related Factors About Diagnostic And Treatment Delays In Patients With Smear-Positive Pulmonary Tuberculosis In Turkey, Mustafa Hami̇dullah Türkkani, Tarkan Özdemi̇r, Çi̇ğdem Özdi̇lekcan Jan 2020

Determination Of Related Factors About Diagnostic And Treatment Delays In Patients With Smear-Positive Pulmonary Tuberculosis In Turkey, Mustafa Hami̇dullah Türkkani, Tarkan Özdemi̇r, Çi̇ğdem Özdi̇lekcan

Turkish Journal of Medical Sciences

Background/aim: This study aimed to analyze delays in diagnosis and treatment by defining the related demographic and clinical factors, to reveal obstacles, and to develop essential attempts to help reduce treatment delays.Materials and methods: We created a questionnaire on the subject of delays in diagnosis and treatment in tuberculosis (TB) control to be administered to the patients. The forms were distributed to dispensaries across the country by the General Directorate of Public Health via an official letter. Results: The study included 853 new patients with smear-positive pulmonary TB. The mean patient delay was 18.06 ± 22.27 days, the mean diagnosis …

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Coenzyme Q10, Zinc And Mda Levels In Verruca Vulgaris, Selma Korkmaz, Fevzi̇ye Burcu Şi̇ri̇n, İjlal Erturan, Hali̇l İbrahi̇m Büyükbayram, Mehmet Yildirim Jan 2020

Coenzyme Q10, Zinc And Mda Levels In Verruca Vulgaris, Selma Korkmaz, Fevzi̇ye Burcu Şi̇ri̇n, İjlal Erturan, Hali̇l İbrahi̇m Büyükbayram, Mehmet Yildirim

Turkish Journal of Medical Sciences

Background/aim: Verruca vulgaris is a benign disease characterized with papillomas on the skin and mucosa. The aim of this study was to investigate the serum levels of coenzyme Q10, MDA, and zinc as well as the lipid profile of verruca vulgaris patients and examine the relationship between these parameters and clinical manifestations of the disease.Materials and methods: The study included 49 verruca vulgaris patients (mean age: 32.01 ± 14.20 years; 22 males, 27 females) and 40 healthy volunteers (mean age: 31.63 ± 8.98 years; 21 males and 19 females). Coenzyme Q10 levels were assessed by using an enzyme-linked immunosorbent assay. …

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Covid-19 And Dermatology, Ülker Gül Jan 2020

Covid-19 And Dermatology, Ülker Gül

Turkish Journal of Medical Sciences

Background/aim: Sars-CoV-2 virus infection (COVID-19) was observed in China in the last months of 2019. In the period following, this infection spread all over the world. In March 2020 the World Health Organization announced the existence of a pandemic. The aim of this manuscript is to investigate skin diseases associated with COVID-19 under three main headings: skin problems related to personal protective equipment and personal hygiene measures, skin findings observed in SARS-CoV-2 virus infections, and skin findings due to COVID-19 treatment agents. Materials and methods: In PubMed, Google Scholar databases, skin lesions related to personal protective equipment and personal hygiene …

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Influence Of Aluminum Salts On Covid-19 Infected Patients, Ali̇ Demi̇r, İbrahi̇m Erayman, Oğuz Doğan, Murat Keki̇lli̇ Jan 2020

Influence Of Aluminum Salts On Covid-19 Infected Patients, Ali̇ Demi̇r, İbrahi̇m Erayman, Oğuz Doğan, Murat Keki̇lli̇

Turkish Journal of Medical Sciences

Background/aim: Based on the antiviral and antibacterial properties of aluminum salts, we aimed to find out the influence of aluminum salts on COVID-19 infected patients. Materials and methods: We performed an observational retrospective cohort study which includes the patients diagnosed as COVID-19 and received aluminum salts in addition to actual treatments during hospitalization as the treatment group (Alum Group). Patients who received standard COVID-19 treatment protocols in the Infectious Diseases Clinics were included as the Control Group. Clinical findings, laboratory parameters, length of stay, survival, radiological follow-up, intensive care and mechanical ventilation needs, the presence of comorbidity, polymerase chain reaction …

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A Single Center Cohort Of 40 Severe Covid-19 Patients Who Were Treated Withconvalescent Plasma, Ali̇i̇hsan Gemi̇ci̇, Hülya Bi̇lgen, Cem Erdoğan, Abdullah Kansu, Oktay Olmuşçeli̇k, Hüseyi̇n Saffet Beköz, Rumeysa Çakmak, Ali̇ Mert, Ömür Gökmen Sevi̇ndi̇k Jan 2020

A Single Center Cohort Of 40 Severe Covid-19 Patients Who Were Treated Withconvalescent Plasma, Ali̇i̇hsan Gemi̇ci̇, Hülya Bi̇lgen, Cem Erdoğan, Abdullah Kansu, Oktay Olmuşçeli̇k, Hüseyi̇n Saffet Beköz, Rumeysa Çakmak, Ali̇ Mert, Ömür Gökmen Sevi̇ndi̇k

Turkish Journal of Medical Sciences

Background/aim: A SARS-Cov2 infection which was first arised from Wuhan in December 2019 and named as COVID-19. Still there lacks either a specific treatment or a vaccine to treat COVID-19. Convalescent plasma (CP) was previously used successfully to treat SARS-CoV-1 and MERS infections. Health authority in Turkey has published a guideline to integrate this promising option in the treatment process of patients who are prone to high risk of developing severe COVID 19. Materials and Methods: Forty consecutive patients who had received CP at our center were included in the study. Demographics, COVID-19 specific parameters, biomarkers to detect the severity …

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Effects Of Immunization Program On Morbidity And Mortality Rates Ofvaccine-Preventable Diseases In Turkey, Tufan Nayi̇r, Ersi̇n Nazlican, Musa Şahi̇n, Fati̇h Kara, Emi̇ne Alp Meşe Jan 2020

Effects Of Immunization Program On Morbidity And Mortality Rates Ofvaccine-Preventable Diseases In Turkey, Tufan Nayi̇r, Ersi̇n Nazlican, Musa Şahi̇n, Fati̇h Kara, Emi̇ne Alp Meşe

Turkish Journal of Medical Sciences

Background/aim: This study aims to serve as a unique consolidated source in Turkey's vaccination history and as an example for other countries by objectively revealing the change in mortality and morbidity rates in Turkey following the beginning of vaccination without asserting any claim on the benefits or risks of vaccines. This unbiased research will also help health professionals identify the challenges more easily when they face with the people who hesitate to vaccinate their children. Materials and methods: Descriptive research design is adopted in this study. The coverages of vaccinations, mortality, and morbidity rates were identified through a retrospective analysis …

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Genetic Evaluation Of Mycobacterium Bovis Isolates With Miru-Vntr And Spoligotyping, Nevi̇n Tuzcu, Fati̇h Köksal Jan 2020

Genetic Evaluation Of Mycobacterium Bovis Isolates With Miru-Vntr And Spoligotyping, Nevi̇n Tuzcu, Fati̇h Köksal

Turkish Journal of Medical Sciences

Background/aim: Determining the epidemiological characteristics of M. bovis strains isolated from human and animal tuberculosis cases will assist in taking more appropriate and effective control measures in controlling tuberculosis originating from animals. Materials and methods: In this study, 32 M. bovis isolates of animal origin and 10 of human origin were isolated and identified in the Çukurova region between March 2011 and June 2012. The 12-locus MIRU-VNTR and spoligotyping methods were used. Results: Six different patterns were determined by spoligotyping and 10 by MIRU-VNTR. When both methods were used together, the number of patterns was found to be 28; MIRU4, …

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Global Threat Of Covid 19 And Evacuation Of The Citizens Of Different Countries, İrfan Şencan, Semanur Kuzi̇ Jan 2020

Global Threat Of Covid 19 And Evacuation Of The Citizens Of Different Countries, İrfan Şencan, Semanur Kuzi̇

Turkish Journal of Medical Sciences

Beginning from China on December 2019, COVID-19 epidemic has spreaded all over the world in a short period of time and has been a pandemic. In challenge with this pandemic quarantine technique has been used widely after tens of years. In the course of the pandemic, many countries evacuated their citizens from affected regions and combined the evacuation with quarantine process. Some examples of these countries who evacuated their citizens are Germany, Italy, Spain, and USA. In further times, during the course of pandemic, according to spread, other countries evacuated their citizens from these countries too. Despite being the origin …

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Emerging And Reemerging Respiratory Viral Infections Up To Covid-19, İlhami̇ Çeli̇k, Esma Saatçi̇, Ayşegül Füsun Eyüboğlu Jan 2020

Emerging And Reemerging Respiratory Viral Infections Up To Covid-19, İlhami̇ Çeli̇k, Esma Saatçi̇, Ayşegül Füsun Eyüboğlu

Turkish Journal of Medical Sciences

Infectious diseases remain as the significant causes of human and animal morbidity and mortality, leading to extensive outbreaks and epidemics. Acute respiratory viral diseases claim over 4 million deaths and cause millions of hospitalizations in developing countries every year. Emerging viruses, especially the RNA viruses, are more pathogenic since most people have no herd immunity. The RNA viruses can adapt to the rapidly changing global and local environment due to the high error rate of their polymerases that replicate their genomes. Currently, coronavirus disease 2019 (COVID-19) is determined as an infectious disease caused by severe acute respiratory syndrome coronavirus 2 …

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Epidemiology Of Covid-19, Cemal Bulut, Yasuyuki̇ Kato Jan 2020

Epidemiology Of Covid-19, Cemal Bulut, Yasuyuki̇ Kato

Turkish Journal of Medical Sciences

It seems that coronaviruses take an important place in the 21th century history. Five of seven human coronavirus was isolated in this century. Unfortunately, last three of them entered our life with a fear of outbreak, pandemic or death. Last human coronavirus which emerged world from Wuhan China, SARS CoV-2 and its clinical expression, Coronavirus disease (COVID-19) recently taken a significant place in our daily practice. Initial reports showed that, its origin was bats. It transmitted human to human by droplet and contact routes, but some doubt about airborne, fecal or intrauterine transmission also should be removed. Its R0 value …

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Novel Coronavirus Disease (Covid-19) In Children, Hasan Tezer, Tuğba Bedi̇r Demi̇rdağ Jan 2020

Novel Coronavirus Disease (Covid-19) In Children, Hasan Tezer, Tuğba Bedi̇r Demi̇rdağ

Turkish Journal of Medical Sciences

Coronavirus disease (COVID-19) was firstly reported at the end of 2019. The disease rapidly spread all around the world in a few months and was declared a worldwide pandemic by WHO in March 2020. By April 9, there were 1,436,198 confirmed COVID-19 cases in the world, nearly with 6% mortality rate. This novel infectious disease causes respiratory tract illness that may generally occur as mild upper respiratory tract disease or pneumonia. In older patients and/or patients with underlying conditions, it may result in acute respiratory distress syndrome, multi organ failure and even death. According to the current literature, children account …

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Covid-19, Immune System Response, Hyperinflammation And Repurposingantirheumatic Drugs, Abdurrahman Tufan, Aslihan Avanoğlu Güler, Marco Matucci-Cerinic Jan 2020

Covid-19, Immune System Response, Hyperinflammation And Repurposingantirheumatic Drugs, Abdurrahman Tufan, Aslihan Avanoğlu Güler, Marco Matucci-Cerinic

Turkish Journal of Medical Sciences

In the Wuhan Province of China, in December 2019, the novel coronavirus 2019 (COVID-19) has caused a severe involvement of the lower respiratory tract leading to an acute respiratory syndrome. Subsequently, coronavirus 2 (SARS-CoV-2) provoked a pandemic which is considered a life-threatening disease. The SARS-CoV-2, a family member of betacoronaviruses, possesses singlestranded positive-sense RNA with typical structural proteins, involving the envelope, membrane, nucleocapsid and spike proteins that are responsible for the viral infectivity, and nonstructural proteins. The effectual host immune response including innate and adaptive immunity against SARS-Cov-2 seems crucial to control and resolve the viral infection. However, the severity …

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Decreasing Incidence And Severity Of Behçet's Disease: A Changing Trend Inepidemiological Spectrum Possibly Associated With Oral Health, Gonca Mumcu, Fatma Ali̇baz Öner, Safi̇ye Atlas Tüli̇n Ergun, Rafi̇ Haner Di̇reskeneli̇ Jan 2020

Decreasing Incidence And Severity Of Behçet's Disease: A Changing Trend Inepidemiological Spectrum Possibly Associated With Oral Health, Gonca Mumcu, Fatma Ali̇baz Öner, Safi̇ye Atlas Tüli̇n Ergun, Rafi̇ Haner Di̇reskeneli̇

Turkish Journal of Medical Sciences

Behçet's disease (BD) is a systemic and inflammatory disorder that is mainly present along the ancient Silk Road, from the Mediterranean Sea to East Asia. A wide range of prevalence figures (0.1-420/100,000) have been reported for BD, also among Turkish populations of similar genetic background living in different countries. Recently, a decline in the incidence of BD and a change of the disease spectrum to less-severe manifestations have been reported from Japan and Korea, two genetically homogenous, affluent populations with limited immigration. It was hypothesized that a decline in infectious diseases, especially dental/periodontal infections, associated with the improvement in oral …

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Update On Liver Transplantation-Newer Aspects, Rahşan Olga Meti̇n, Cem Şi̇mşek, Ahmet Ömür Gürakar Jan 2020

Update On Liver Transplantation-Newer Aspects, Rahşan Olga Meti̇n, Cem Şi̇mşek, Ahmet Ömür Gürakar

Turkish Journal of Medical Sciences

Liver transplantation (LT) remains the only therapeutic option offering gold standard treatment for end-stage liver disease (ESLD) and acute liver failure (ALF), as well as for certain early-stage liver tumors. Currently, the greatest challenge facing LT is the simple fact that there are not enough adequate livers for all the potential patients that could benefit from LT. Despite efforts to expand the donor pool to include living and deceased donors, organ shortage is still a major problem in many countries. To solve this problem, the use of marginal liver grafts has become an inevitable choice. Although the definition of marginal …

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Thiol-Disulfide Homeostasis: An Integrated Approach With Biochemical And Clinical Aspects, Özcan Erel, Serpi̇l Erdoğan Jan 2020

Thiol-Disulfide Homeostasis: An Integrated Approach With Biochemical And Clinical Aspects, Özcan Erel, Serpi̇l Erdoğan

Turkish Journal of Medical Sciences

Dynamic thiol-disulfide homeostasis (TDH) is a new area has begun to attract more scrutiny. Dynamic TDH is reversal of thiol oxidation in proteins and represents the status of thiols (-SH) and disulfides (-S-S-). Organic compounds containing the sulfhydryl group is called thiol, composed of sulfur and hydrogen atoms. Disulfides are the most important class of dynamic, redox responsive covalent bonds build in between two thiol groups. For many years, thiol levels were analyzed by several methods. During last years, measurements of disulfide levels have been analyzed by a novel automated method, developed by Erel and Neselioglu. In this method, addition …

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Is There Relationship Between Sars-Cov-2 And The Complement C3 And C4?, Hamad Dhei̇r, Savaş Si̇pahi̇, Selçuk Yaylaci, Mehmet Köroğlu, Ali̇ Fuat Erdem, Oğuz Karabay Jan 2020

Is There Relationship Between Sars-Cov-2 And The Complement C3 And C4?, Hamad Dhei̇r, Savaş Si̇pahi̇, Selçuk Yaylaci, Mehmet Köroğlu, Ali̇ Fuat Erdem, Oğuz Karabay

Turkish Journal of Medical Sciences

No abstract provided.

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Melatonin, Aging, And Covid-19: Could Melatonin Be Beneficial For Covid-19 Treatment In The Elderly?, Güler Öztürk, Kazi̇me Gonca Akbulut, Şevi̇n Güney Jan 2020

Melatonin, Aging, And Covid-19: Could Melatonin Be Beneficial For Covid-19 Treatment In The Elderly?, Güler Öztürk, Kazi̇me Gonca Akbulut, Şevi̇n Güney

Turkish Journal of Medical Sciences

The aim of this review is to summarize current studies on the relationship between melatonin and aging. Nowadays, age-related diseases come into prominence, and identifying age-related changes and developing proper therapeutic approaches are counted as some of the major issues regarding community health. Melatonin is the main hormone of the pineal gland. Melatonin is known to influence many biological processes in the body, including circadian rhythms, the immune system, and neuroendocrine and cardiovascular functions. Melatonin rhythms also reflect the biological process of aging. Aging is an extremely complex and multifactorial process. Melatonin levels decline considerably with aging and its decline …

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The Problem With Relying On Profit-Driven Models To Produce Pandemic Drugs, Ana Santos Rutschman Jan 2020

The Problem With Relying On Profit-Driven Models To Produce Pandemic Drugs, Ana Santos Rutschman

All Faculty Scholarship

The longstanding problems of relying on a market response to a pandemic are becoming readily apparent in the United States, which has quickly become the epicenter of the COVID-19 outbreak. The problems are particularly pronounced in pharmaceutical markets, where we are pinning our hopes for both cures and vaccines. In previous work we have shown how characteristics of healthcare markets in the United States create a divergence between the private incentives of for-profit companies and public health needs, leading to sub-optimal health outcomes in what is a uniquely market-driven healthcare system. In this Essay, written as the COVID-19 pandemic unfolds, …

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