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International Multi-Center Study Of Middle Meningeal Artery Embolization For Chronic Subdural Hematoma In Cancer Patients: Efficacy, Safety, And Outcomes In A High-Risk Population, Avi A Gajjar, Mohamed M Salem, Georgios S Sioutas, Rashad Jabarkheel, Okkes Kuybu, Jane Khalife, Daniel A Tonetti, Gustavo Cortez, Adam A Dmytriw, Diego Alejandro Ortega Moreno, William Smith, Robert W Regenhardt, Kate T Carroll, Zachary A Abecassis, Juan Francisco Ruiz Rodriguez, Oleg Shekhtman, Alex Nguyen Hoang, Alexander A Khalessi, Cordell Baker, Matthias Matejka, Nicole M Cancelliere, Christoph J Griessenauer, Ramesh Grandhi, Peter Kan, Omar Tanweer, Michael R Levitt, Christopher J Stapleton, Vitor Mendes Pereira, Brian Jankowitz, Howard A Riina, Aman B Patel, Ricardo Hanel, Ajith J Thomas, Michael J Lang, Bradley A Gross, Jan-Karl Burkhardt, Visish M Srinivasan

Faculty, Staff and Students Publications

Background

Middle meningeal artery embolization (MMAE) is a promising treatment for chronic subdural hematoma (cSDH). Cancer patients are at risk for cSDH due to thrombocytopenia. The efficacy of MMAE in this population has not been studied.

Methods

We conducted a retrospective analysis of 76 patients who underwent 94 MMAEs for cSDH at 12 tertiary centers across North America and Europe between February 2018 and January 2023. We analyzed patient demographics, clinical profiles, procedural details, and outcomes. The primary outcome was cSDH progression, while secondary outcomes included radiographic resolution, mortality, 90-day functional outcomes, functional improvement, and procedural complications.

Results

Radiographic improvement …

Smooth Muscle Cells And Fibroblasts In The Ascending Aorta Exhibit Minor Differences Between Embryonic Origins In Angiotensin Ii-Driven Transcriptional Alterations, Sohei Ito, David B Graf, Yuriko Katsumata, Jessica J Moorleghen, Chen Zhang, Yanming Li, Scott A Lemaire, Ying H Shen, Hong S Lu, Alan Daugherty, Hisashi Sawada

Faculty, Staff and Students Publications

Thoracic aortopathy is influenced by angiotensin II (AngII) and exhibits regional heterogeneity with the ascending aorta being particularly susceptible. In this region, smooth muscle cells (SMCs) and selected fibroblasts originate from the second heart field (SHF) and cardiac neural crest (CNC). While our previous study revealed a critical role of SHF-derived cells in AngII-mediated aortopathy, the contribution of CNC-derived cells remains unclear. To investigate lineage-specific responses to AngII, Mef2c-Cre R26RmT/mG mice were infused with AngII. Ascending aortas were harvested at baseline or after 3 days of infusion, representing the prepathological phase. Cells were sorted based on their embryonic origins and …

Dnmt3a Regulates Murine Megakaryocyte-Biased Hematopoietic Stem Cell Fate Decisions, Sarah M Waldvogel, Virginia Camacho, Dandan Fan, Anna G Guzman, Alejandra Garcia-Martell, Elmira Khabusheva, Jacey Rodriguez Pridgen, Josephine De La Fuente, Rachel Rau, Ashlyn G Laidman, Maria N Barrachina, Estelle Carminita, Justin A Courson, Michael R Williamson, Joanne I Hsu, Chun-Wei Chen, Jaime Reyes, Subhashree Pradhan, Rolando E Rumbaut, Alan R Burns, Benjamin Deneen, Jianzhong Su, Kellie R Machlus, Margaret A Goodell

Center on Aging Staff Publications

Hematopoietic stem cells (HSCs) are defined by their capacity to regenerate all main components of peripheral blood, but individual HSCs exhibit a range of preferences for generating downstream cell types. Their propensities are thought to be epigenetically encoded, but few differential regulatory mechanisms have been identified. In this work, we explored the role of DNA methyltransferase 3A (DNMT3A) in the megakaryocyte-biased HSC population, which is thought to reside at the top of the hematopoietic hierarchy. We demonstrate that heterozygous loss of DNMT3A (Dnmt3a+/-) in these megakaryocyte-biased HSCs has distinct consequences compared with the rest of the HSC pool. These megakaryocyte-biased …

Low-Dose Bevacizumab Treatment For Retinopathy Of Prematurity, Makayla Ayres, Katherine Brown Md

Research Days

Background: Retinopathy of prematurity (ROP) is an eye disease that affects very premature infants and causes blindness. Treatment for ROP consists of anti-VEGF intravitreal injections (e.g., bevacizumab), laser therapy, and cryotherapy. The concern of anti-VEGF intravitreal injections is systemic toxicity and potential detrimental effects on these developing infants. In research trials, doses as low as 0.031 mg of bevacizumab have been shown to be effective in treating ROP. However, in clinical practice, the most common doses used are 0.125-0.25 mg.

Objectives/Goal: At CMKC, 0.075 mg doses of bevacizumab have been used to treat Type 1 ROP since 2022. We aim …

Defining Three Principles For Credible Evidence Synthesis And Reviews In Health Professions Education, Michelle Daniel, Morris Gordon, Hussein Uraiby, Peter Boedeker, Janice Hanson, Diana Dolmans, Satid Thammasitboon

Faculty, Staff and Students Publications

As reviews become increasingly central to informing educational practice and guiding research in health professions education, the need for methodological clarity and quality has grown. This Commentary highlights three foundational principles - alignment, rigor, and transparency - that underpin high-quality reviews, regardless of type. We illustrate how these principles apply across commonly used review types, including systematic, scoping, realist, and narrative reviews. By aligning the research question with the appropriate review methodology, employing rigorous processes for evidence collection and synthesis, and maintaining transparency in methodological reporting, review teams can produce credible, transferable, and dependable findings. Embracing these principles not only …

Intouch Week Of May 12, 2025, New York Medical College

InTouch

• Commencement Speakers Set to Inspire Class of 2025
• Students Express Gratitude to Their First Patients During Convocation of Thanks
• Harnessing Digital Innovations in Ophthalmic Surgery
• TCDM Hosts Sixth Annual Convocation and Induction Ceremony
• TCDM’s Fourth Annual Research Day and Poster Competition Recognizes Student Researchers and Faculty Mentors
• Student Spotlight: Lynne MacFadyen Aspires to Help Others Find Their Voice
• Student Spotlight: Callie Hollander Finds Her Rhythm in Neuroscience Research

Risk Of Coronary Obstruction In Redo-Transcatheter Aortic Valve Replacement Between Bicuspid And Tricuspid Aortic Valves, Atsushi Okada, Syed Zaid, Miho Fukui, Evan Walser-Kuntz, Larissa I Stanberry, Marcus R Burns, John R Lesser, João L Cavalcante, Paul Sorajja, Vinayak N Bapat

Faculty, Staff and Students Publications

Background: Transcatheter aortic valve replacement (TAVR) is approved across all risk profiles, including patients with bicuspid aortic valves. These patients are generally younger, with a higher chance of reintervention.

Objectives: The aim of this study was to compare the feasibility of redo transcatheter aortic valve (TAV) between bicuspid and tricuspid aortic valves.

Methods: A computed tomographic (CT) simulation of redo-TAV was conducted using 913 post-TAVR CT studies from patients who underwent TAVR with SAPIEN 3 or SAPIEN 3 Ultra (S3; n = 623) or Evolut R, Evolut PRO, or Evolut PRO+ (Evolut; n = 290) valves. Fifty-nine cases were for …

Structural Proteomics Defines A Sequential Priming Mechanism For The Progesterone Receptor, Matthew D Mann, Min Wang, Josephine C Ferreon, Phoebe S Tsoi, Michael P Suess, Antrix Jain, Anna Malovannaya, Roberto Vera Alvarez, Bruce D Pascal, Raj Kumar, Dean P Edwards, Patrick R Griffin

Faculty, Staff and Students Publications

The progesterone receptor (PR) is a steroid-responsive nuclear receptor with two isoforms: PR-A and PR-B. Disruption of PR-A:PR-B signaling is associated with breast cancer through interactions with oncogenic co-regulatory proteins (CoRs). However, molecular details of isoform-specific PR-CoR interactions remain poorly understood. Using structural mass spectrometry, we investigate the sequential binding mechanism of purified full-length PR and intact CoRs, steroid receptor coactivator 3 (SRC3) and p300, as complexes on target DNA. Our findings reveal selective CoR NR-box binding by PR and unique interaction surfaces between PR and CoRs during complex assembly, providing a structural basis for CoR sequential binding on PR. …

Relationship Between Maternal Plasma Retinol And Provitamin A Carotenoids With Fetal And Infant Kidney Development, Anum Akbar

Theses & Dissertations

Vitamin A plays a critical role in fetal organ development. Studies suggest that maternal vitamin A deficiency affects fetal nephron numbers, potentially leading to smaller kidney sizes and an increased risk of chronic kidney disease later in life. However, human studies exploring maternal vitamin A's impact on fetal kidney development lack longitudinal data and within-cohort comparisons. Furthermore, the influence of provitamin A carotenoids (α-carotene, β-carotene, β-cryptoxanthin) on kidney size remains unexplored. This dissertation addresses these gaps by analyzing relationships between maternal and cord plasma retinol and provitamin A carotenoid concentrations with fetal and infant kidney sizes. Our prospective cohort …

Identification And Preclinical Assessment Of Novel Therapeutic Modalities In Environmental Exposure-Induced Lung Disease, Aaron D. Schwab

Theses & Dissertations

Environmental lung diseases are preventable respiratory conditions either caused or made worse by inhaled environmental exposures. Contemporarily, environmental lung diseases are most associated with workplace exposures given specific occupational processes aerosolize inflammatory agents that can be inhaled at high concentrations. Although a considerable amount is known regarding immunoglobulin (Ig)E-mediated responses to environmental exposures, little is known about non-IgE mediated respiratory conditions resulting from lipopolysaccharide (LPS)-enriched organic dust exposure(s). Chronic respiratory diseases such as asthma, hypersensitivity pneumonitis, chronic obstructive pulmonary disease (COPD), and pulmonary fibrosis have all been identified as environmental lung diseases caused or exacerbated by such environmental dusts. Therapeutic …

Evaluation Of The Usage And Effectiveness Of The Gross Anatomy Osteology E-Learning Module, Conor Young

Theses & Dissertations

Supplementary online learning modalities have reached near ubiquity in graduate health sciences education, yet evidence about their effectiveness remains mixed. The Department of Genetics, Cell Biology, and Anatomy at UNMC recently introduced their own bespoke electronic study platform called the Osteology e-Learning Module to aid gross anatomy students in the study of osteology. To assess its effectiveness, osteology and whole gross lab practical exam scores were compared in four different content units across three school year cohorts of graduate students in the same gross anatomy class. A survey was also distributed to one cohort to capture subjective information about the …

Evaluating The Therapeutic Potential Of Geranylgeranyl Diphosphate Synthase Inhibitor, Ram2061, In Myeloma Bone Disease, Molly Muehlebach

Theses & Dissertations

Multiple myeloma (MM) is a hematological malignancy of the plasma cells which often results in lytic bone disease. Myeloma bone disease (MBD), characterized by diffuse osteopenia, bone lesions, or pathological fracture, results from MM mediated promotion of osteoclast resorption and dual inhibition of bone formation, drastically reducing bone strength and integrity. Development of MBD is known to significantly impact patient quality of life and increase risk of mortality. Considering that up to 80-95% of MM patients are expected to develop bone disease post-initial MM diagnosis, there is a significant need within this population for therapeutics which address both MM disease …

Relationships Between Health Behaviors And Markers Of Oxidative Stress And Inflammation On Blood Pressure, Alison M. Godfrey

Honors Scholar Theses

Background. Young adulthood is a period when cardiometabolic risk factors begin to emerge. Developing cardiometabolic risk early can increase the risk and severity of chronic illness across the lifespan. Despite this, young adults are often understudied particularly as it relates to major cardiometabolic risk factors such as blood pressure (BP) and risk of hypertension. Hypertension is a public health crisis and early indicators of hypertension risk should be more thoroughly researched. Therefore, the purpose of the presented thesis is to examine BP in young adults and two potential pathways by which risk may emerge in young adults; inflammation (C-Reactive …

Anti-Cancer Activity Of Marine-Derived Fucosylated Chondroitin Sulfates In Ovarian Cancer Cell Spheroid Formation And Notch Signaling Inhibition, Daniella Beiner

Honors Theses

Ovarian cancer is the deadliest gynecological malignancy, with high recurrence rates driven by chemotherapy-resistant cancer stem cells (CSCs). Current therapeutics targeting Notch signaling to inhibit CSC formation have yet to demonstrate clinical benefit and pose risk of gastrointestinal toxicities. Here, we report that treatment with fucosylated chondroitin sulfates (FucCS) inhibited Notch signaling activation and spheroid formation in OVCAR3 ovarian cancer cells. Sulfation and fucosylation were shown to be key structural requirements of this anti-cancer activity. Moreover, this inhibition was synergistic with suppression of Notch glycosylation by Radical Fringe knockout. Preliminary experiments to conjugate FucCS to a maleimide linker in preparation …

The Endocannabinoid System's Influence And Modulation Of Nociception, Doreen M. Flannery

Honors Thesis

The anatomy and physiology of pain is a well-defined pathway where noxious stimuli is processed by different systems in the brain. The central research question of this review is how can we better understand the neurobiological effects pain has, and assess if there is therapeutic potential in using endocannabinoids to modulate these effects. Endocannabinoids are signaling molecules that play a key role at both the cellular and molecular level in modulating both acute and chronic pain by influencing different processes within each level that affect how the body responds to both internal and external stimuli. The endocannabinoid system is a …

Allogeneic Chimeric Antigen Receptor T-Cell Products Cemacabtagene Ansegedleucel/Allo-501 In Relapsed/Refractory Large B-Cell Lymphoma: Phase I Experience From The Alpha2/Alpha Clinical Studies, Frederick L Locke, Javier L Munoz, Michael T Tees, Lazaros J Lekakis, Sven De Vos, Rajneesh Nath, Don A Stevens, Shahbaz A Malik, Geoffrey P Shouse, Mehdi Hamadani, Olalekan O Oluwole, Miguel-Angel Perales, David B Miklos, Paul W Fisher, Amy Feng, Lynn Navale, John B Le Gall, Sattva S Neelapu

Faculty, Staff and Student Publications

Purpose: Off-the-shelf, allogeneic CD19 chimeric antigen receptor (CAR) T-cell products may improve access to treatment versus autologous ones. We report the phase I experience of the allogeneic CD19 CAR T-cell product cemacabtagene ansegedleucel (cema-cel) and its predecessor, ALLO-501, in CD19 CAR T-naïve patients with relapsed/refractory large B-cell lymphoma (R/R LBCL).

Methods: In the ALPHA2/ALPHA studies, the safety and efficacy of allogeneic CD19 CAR T cells were evaluated in CD19 CAR T treatment-naïve patients with R/R LBCL. Patients received healthy donor-derived, human leukocyte antigen-unmatched cema-cel/ALLO-501 following a 3-day lymphodepletion regimen of fludarabine (30 mg/m2 once daily), cyclophosphamide (300 or 500 mg/m2 …

New First Trimester Circulating Angiogenic Biomarkers In Predicting Early-Onset And Late-Onset Fetal Growth Restriction: A Case-Control Study, Xiaoyi Bai, Wei Li, Wenjing Ding, Oi Ka Chan, Maran Bo Wah Leung, So Ling Lau, Daljit Singh Sahota, Chi Chiu Wang, Tak Yeung Leung

Faculty, Staff and Students Publications

Background: First trimester prediction of fetal growth restriction (FGR) remain suboptimal. We aimed to search for new circulating angiogenic biomarkers for improvement.

Methods: This case-control study compared 73 singleton pregnancies with early or late-onset FGR based on Delphi consensus and 73 matched normal controls. Their maternal serum samples stored during 11-13 weeks were retrieved for measurement of 36 angiogenic biomarkers by MILLIPLEX® human angiogenesis magnetic bead panels. Those biomarkers that showed significant differences between the study groups were further analysed with receiver operating characteristic (ROC) curve.

Results: In the early-onset FGR group, log10MoM of soluble neuropilin-1 (sNRP-1: 0.08 ± 0.11 …

Letter To The Editor On “Timing Of Puberty Suppression In Transgender Adolescents And Sexual Functioning After Vaginoplasty (Van Der Meulen Et Al., 2024)”, Alison Clayton, Jilles Smids, Kathleen Mcdeavitt

Faculty, Staff and Students Publications

No abstract provided.

Region-Specific Brain Targets Drive Circuit Formation And Maturation Of Human Retinal Ganglion Cells, Kang-Chieh Huang, Han-Yin Jeng, Qudrat Abdulwahab, Victoria R Cuevas, Eyad Shihabeddin, Claire Young, Melody Hernandez, Jason S Meyer, Nicholas M Tran, Melanie A Samuel

Faculty, Staff and Students Publications

Human vision relies on retinal ganglion cells (RGCs), and their connectivity with distinct brain regions enables higher order visual processing. RGCs vary considerably between species, and small model organisms display distinct RGC innervation patterns from that in humans. There is thus a need for robust models of human RGC circuit formation that preserves innervation specificity. Here, we developed an in vitro microfluidics eye-to-brain connectivity model using human pluripotent stem cell (hPSC)-derived RGCs to assess brain region-specific connectivity features. We find that cultured human RGCs segregate their dendrites and axons and display axonal features that align with that of their in …

Computational Modeling Of Cancer Cell Metabolism Along The Catabolic-Anabolic Axes, Javier Villela-Castrejon, Herbert Levine, Benny A Kaipparettu, José N Onuchic, Jason T George, Dongya Jia

Faculty, Staff and Students Publications

Abnormal metabolism is a hallmark of cancer, this was initially recognized nearly a century ago through the observation of aerobic glycolysis in cancer cells. Mitochondrial respiration can also drive tumor progression and metastasis. However, it remains largely unclear the mechanisms by which cancer cells mix and match different metabolic modalities (oxidative/reductive) and leverage various metabolic ingredients (glucose, fatty acids, glutamine) to meet their bioenergetic and biosynthetic needs. Here, we formulate a phenotypic model for cancer metabolism by coupling master gene regulators (AMPK, HIF-1, MYC) with key metabolic substrates (glucose, fatty acids, and glutamine). The model predicts that cancer cells can …

Let-7 Restrains An Epigenetic Circuit In At2 Cells To Prevent Fibrogenic Intermediates In Pulmonary Fibrosis, Matthew J Seasock, Md Shafiquzzaman, Maria E Ruiz-Echartea, Rupa S Kanchi, Brandon T Tran, Lukas M Simon, Matthew D Meyer, Phillip A Erice, Shivani L Lotlikar, Stephanie C Wenlock, Scott A Ochsner, Anton Enright, Alex F Carisey, Freddy Romero, Ivan O Rosas, Katherine Y King, Neil J Mckenna, Cristian Coarfa, Antony Rodriguez

Faculty, Staff and Students Publications

MicroRNA-mediated post-transcriptional regulation of lung alveolar type 2 (AT2) and AT1 cell differentiation remains understudied. Here, we demonstrate that the let-7 miRNA family plays a homeostatic role in AT2 quiescence by preventing the uncontrolled accumulation of AT2 transitional cells and promoting AT1 differentiation. Using mouse and organoid models, we show that genetic ablation of let-7a1/let-7f1/let-7d cluster (let-7afd) in AT2 cells prevents AT1 differentiation and leads to KRT8 transitional cell accumulation in progressive pulmonary fibrosis. Integration of AGO2-eCLIP with RNA-sequencing identified direct let-7 targets within an oncogene feed-forward regulatory network, including BACH1/EZH2/MYC, which drives an aberrant fibrotic cascade. Additional CUT&RUN-sequencing analyses …

F-Test And One-Way Anova For Medical Images Diagnosis, Jamal Kamil K. Abbas, Ali Abdulkadhum Ruhaima

Al-Nisour Journal for Medical Sciences

A new technique for impulse noise discrimination of medical MRI images is presented. Statistical F-distribution supported by Monte Carlo simulation for prediction of impulse noise location on distorted images is used. The selective noisy pixels are detected as noisy using the One-Way ANOVA hypothesis method. The statistical prediction method is applied to the test images to predict the noise location. The distorted portions in the images predicted by this structure are improved by using a proper nonlinear filter. The nonlinear median filter is showing a suitable way the replacement of degraded pixels. The filter is not applied to the not-detected …

Histological Changes Of Mesenteric Lymph Nodes Affected By Cadmium Chloride In Male Albino Rat: Experimental Study, Umalbaneen Hilal Hadi, Safa J. Al-Yassir, Warkaa M. Ali Alwattar

Al-Nisour Journal for Medical Sciences

Background: Cadmium (Cd) is a toxic heavy metal can be found in many sources, including cigarette smoke, e-cigarettes, batteries, contaminated water, plant-based foods, air, fertilizers, plastic toys, ceramics, soil and paints. the exposure to environmental factors may affect different body systems including lymphatic system.

Objectives: to investigate the effect of ingested cadmium chloride on mesenteric lymph nodes in rat.

Materials and Methods: twenty adult male albino rats were used in this study, which divided equally into two groups, on group served as control group administrated of tap water while the second group used as experimental group exposed to daily …

Relationship Between Renal And Liver Function With Diabetic Retinopathy In Patients With Type 2 Diabetes Mellitus In Iraq, Muataz Mohammed Al-Taee

Al-Nisour Journal for Medical Sciences

It is guessed that this study would take a gander at the connection among liver and kidney function and the predominance and severity of diabetic retinopathy (DR) in Iraqi people with type 2 diabetes mellitus (T2DM). three hundred T2DM patients that were browsed Iraqi tertiary thought offices partook in a cross-sectional survey. Segmental, clinical, and biochemical information were gathered, including liver function tests (e.g., alanine aminotransferase [ALT], aspartate aminotransferase [AST], and gamma-glutamyl transferase [GGT]) and renal function tests (e.g., serum creatinine, evaluated glomerular filtration rate [eGFR], and albuminuria). Fundoscopic assessment of DR was directed to recognize proliferative diabetic retinopathy (PDR), …

Automated Retinal Vessel Analysis: A Novel Model For Blood Vessel Detection, Segmentation, And Clinical Characteristic Quantification, Aws A. Abdulsahib, Moamin A. Mahmoud, Sally A. Al-Hasnawi, Ahmed Zeyad Almhanna, Jamal Kamil K. Abbas

Al-Nisour Journal for Medical Sciences

This research enlightens into a fully automated model for segmenting blood vessels and extracting clinical features from retinal fundus images, which is vital for diagnosing ophthalmologic and cardiovascular diseases. The model utilises contrast enhancement, noise reduction, edge detection, and a method for reconnecting blood vessel branches. It extracts properties like tortuosity, girth, and length of blood vessels. The model's performance surpasses existing approaches, achieving high accuracy, sensitivity, specificity, and positive and negative prediction values on DRIVE and HRF datasets. This innovation offers the potential to reduce specialists' workload, enhance diagnostic accuracy, and streamline the analysis of complex fundus images, ultimately …

Shohani Save Guard (Ssg): Dietary Supplement To Support Drug Addiction Treatment, Mohammed Mahdi Salman Ghadban, Taghreed Khudhur Mohammed

Al-Nisour Journal for Medical Sciences

Shohani Save Guard (SSG) is a scientifically formulated dietary supplement designed to aid in the recovery from drug addiction, particularly methamphetamine addiction. This study explores the biochemical and biological mechanisms through which SSG's natural ingredients, including KSM-66, Panax Ginseng, Bacopa Monnieri, Green Tea, Curcumin, and other essential vitamins and minerals, work synergistically to promote recovery. The paper also reviews recent studies supporting the efficacy of these ingredients and highlights their roles in reducing addiction symptoms and improving overall health.

Evaluating Chemical Security And Safety Levels In Tanning Factories At The General Company For Textile And Leather Industries/Leather Factory In Iraq, Fatima Khudhur Mohammed, Taghreed Khudhur Mohammed, Salwa Hameed Naser Al-Rubae’I

Al-Nisour Journal for Medical Sciences

Most of the chemicals produced and used today are beneficial, but some also have the potential to damage human health and the environment. To achieve the goal of allowing the use of chemicals for companies and factories, safety and security tools were used in the laboratories, and workers were trained on the dangers of chemicals. We studied worker exposure to hazardous chemicals and determined the prevalence of occupational skin diseases. As well as examining the availability of personal protective equipment. A questionnaire was used to determine the chemicals used, the ages of the employees, their educational level, and the extent …

Synthesis, Structural Characterization, And In-Vitro Cytotoxicity Of Zinc-Levofloxacin Ligand, Khalid Ibrahim Adwan, Falah M. K. Al-Rekabi

Al-Nisour Journal for Medical Sciences

Background: This study aimed to modify levofloxacin and evaluate its cytotoxicity as well as the synthesis, characterization and physical evaluation of mixed ligand zinc complex with the third generation quinolones’ representative, levofloxacin. Levofloxacin coupled to zinc through one pyridone and one carboxylate oxygen as well as with two nitrogen atoms from the heteroligand, as demonstrated by the complexation of zinc (II) metal ion with the deprotonated ligand and heteroligand. The identification of the complex structure was carried out using Fourier Transform Infrared Spectroscopy, Hydrogen-Nuclear Magnetic Resonance, melting point, and UV–visible spectrophotometry.

Results: Binding of the zinc on the two donor …

Human Monkeypox Virus; New Possible Viral Pandemic, Lamiaa Mohammed, Alyaa Jabbar Qasim, Ayat Majeed Zeadan

Al-Nisour Journal for Medical Sciences

The unexpected monkeypox outbreak and global increase have drawn attention due to the ongoing COVID-19 pandemic. With 3340 confirmed cases worldwide as of June 22, 2022, this is the biggest and most pervasive monkeypox outbreak outside of Africa. In addition to vertical transmission from mother to child, MPXV can spread from person to person through direct contact with infectious skin or mucosal skin lesions, respiratory droplets, or indirect contact with contaminated objects or materials. Additionally, it is most likely sexually transmitted through vaginal fluid or semen, and community transmission is a possibility. MPXV, an envelope, linear, double-stranded DNA virus that …

The Digital Dilemma: How Social Media Is Affecting Our Emotional Well-Being, Jasim Aymen Khaleefah, Ban Yousif Yaaqoob

Al-Nisour Journal for Medical Sciences

Internet and Social media have become an essential part of our daily routine, allowing us to connect and be close with others, share information, and engage in various activities. Nevertheless, the extensive use of social media has raised many questions about its influence on our health and emotional well-being. The purpose of this review is to provide an in-depth analysis of the literature on how social media distresses our emotional well-being. Current review was conducted by investigating existing literature, the works was obtained through searches on academic databases, including PubMed, PsycINFO, and Google Scholar. The literature found that social networking …