Digital Commons Network^™

The Behaviour And Attitude Of Physicians In The Lakes Region Towards Smoking, Rezan Demi̇ralay

Turkish Journal of Medical Sciences

This study was carried out on 401 physicians who work in the Lakes region, Turkey, to assess their behaviour and attitude towards smoking. A questionnaire based on guidelines and standardised questions prepared by the World Health Organization was given to physicians. Of the physicians, 136 (33.9%) had never tried to smoke in their lives and 45 (11.2%) were former smokers. Of the 220 (54.9%) physicians who had smoked for at least 6 months in their lifetime, 46 (11.5%) were ex-smokers. Of the current smokers, 135 (77.6%) were daily smokers and 39 (22.4%) were occasional smokers. Fifty-two (43.7%) general practitioners, 34 …

The Prevalence Of Chronic Diseases And Quality Of Life In Elderly People In Samsun, Sevgi̇ Canbaz, Ahmet Tevfi̇k Sünter, Sennur Dabak, Yildiz Pekşen

Turkish Journal of Medical Sciences

The increasing aged population has recently become a focus of interest in developing countries. The aims of our study were to evaluate chronic diseases and measure the quality of life of elderly people in Samsun. A cross-sectional study was conducted between March 1 and April 30,2001. There were 8350 elderly people in the study area. The study group consisted of 835 elderly people, calculated by using the sample size formula. Except for 98 (11.7%) individuals, 737 of 835 elderly people participated in this study. In the first step of the study, the data of 737 elderly people were used, and …

Paraplegia Due To Extramedullary Hematopoiesis In The Thalassemia Intermedia, Şule Peker, Mehmet Çelebi̇soy, İsmai̇l Akkol, Hamdi̇ Bezi̇rci̇oğlu

Turkish Journal of Medical Sciences

ER^1, Mehmet ÇELEBİSOY^1, İsmail AKKOL^2, Hamdi BEZİRCİOĞLU^2 ^1Atatürk Education and Research Hospital Second Neurology Clinic, İzmir - Turkey ^2Atatürk Education and Research Hospital Neurosurgery Clinic, İzmir - Turkey

Abdominal Actinomycosis Appearing As An Intraabdominal Tumoral Mass, Ömer Şakrak, İpek Müderri̇soğlu, Abdulkadi̇r Bedi̇rli̇, Özhan İnce, Özlem Canöz

Turkish Journal of Medical Sciences

RAK^1 İpek MÜDERRİSOĞLU^2 Abdulkadir BEDİRLİ^1 Özhan İNCE^1 Özlem CANÖZ^3 Departments of ^1General Surgery, ^2Obstetrics and Gynecology, ^3Pathology, Faculty of Medicine, Erciyes University, Kayseri - Turkey

The Pathology Of Echinococcosis And The Current Echinococcosis Problem In Western Turkey (A Report Of Pathologic Features In 80 Cases, M. Şerefetti̇n Canda, Meri̇h Güray, Tülay Canda

Turkish Journal of Medical Sciences

Echinococcosis is an infection caused by Echinococcus granulosus and E. multilocularis. It manifests as cyst formations in various organs, affecting both humans and animals. The cysts may be unilocular (E. granulosus) or multilocular (E. multilocularis). Multilocular cysts have particular significance, for their macroscopic appearance is reminiscent of malignant tumors and their prognosis is poor. The purpose of this study is to describe our cases and to start a discussion on the current echinococcosis problem in İzmir, western Anatolia. The pathological features of 80 cases of echinococcosis diagnosed at Dokuz Eylül University Pathology Department over the last 21 years have been …

Bioavailability Of The Tea Flavonoids Epicatechin And Epicatechin Gallate: Role Of Membrane Transport And Metabolism, Jaya Bharathi Vaidyanathan

MUSC Theses and Dissertations

Tea flavonoids, including (-)-epicatechin (EC), (-)-epicatechin gallate (ECG), (-)-epigallocatechin gallate (EGCG) and (-)-epigallocatechin (EGC) have been shown to have chemopreventive activity in cancer. Studies in animals and humans suggest that these dietary compounds have a very low oral bioavailability. However, the reason behind this limited bioavailability as well as the mechanisms underlying absorption is not clearly understood. The overall hypothesis of this dissertation project is that the human intestinal absorption of (-)-epicatechin (EC) and its gallate, (-)epicatechin- 3-gallate (ECG) is limited and regulated both by multiple transport mechanisms and metabolism. We used the Caco-2 cell monolayers, a well-established model to …

Good Life In The Balance: A Cross-National Study Of Dutch And Australian Disability Perspectives On Euthanasia And Physician-Assisted Suicide, Erik A. Leipoldt

Theses: Doctorates and Masters

This is a cross-national qualitative study with the purpose of obtaining perspectives held by people with quadriplegia and leading figures in disability movements in the Netherlands and Australia on the issues of euthanasia and physician-assisted suicide (EPAS). A disability voice is not prominent in public debate on EPAS in Australia or the Netherlands, even though people with disabilities are often thought to be vulnerable in relation to EPAS policies. Disability perspectives are potentially valuable in illuminating issues in relation to euthanasia and physician-assisted suicide, because issues of dependence, independence, and individual autonomy play important roles in relation to both EPAS …

A Contrast-Based Neural Control System For Ant Navigation, Joanna R. Wares, Predrag-Peter Ilich, Daniel P. Dougherty

Department of Math & Statistics Faculty Publications

A mathematical model for a neural control system of ant locomotion was developed. Contrast-based detectors using excitation and inhibition were tuned to specific contrast orientations. A control system using multiple orientation contrast detectors was then developed and optimized for a model ant, which could move via a biased random walk. The system allowed sufficient control to guide the ant through various mazes.

Genetic Health And Eugenics Precedents: A Voice Of Caution, Larry I. Palmer

Faculty Publications

No abstract provided.

A Genetic Lesion That Arrests Plasma Cell Homing To The Bone Marrow, Loren D. Erickson, Ling-Li Lin, Biyan Duan, Laurence Morel, Randolph J. Noelle

Dartmouth Scholarship

The coordinated regulation of chemokine responsiveness plays a critical role in the development of humoral immunity. After antigen challenge and B cell activation, the emerging plasma cells (PCs) undergo CXCL12-induced chemotaxis to the bone marrow, where they produce Ab and persist. Here we show that PCs, but not B cells or T cells from lupus-prone NZM mice, are deficient in CXCL12-induced migration. PC unresponsiveness to CXCL12 results in a marked accumulation of PCs in the spleen of mice, and a concordant decrease in bone marrow PCs. Unlike normal mice, in NZM mice, a majority of the splenic PCs are long-lived. …

Development Of An Automated Thiopurine Methyltransferase (Tpmt) Genotyping Assay, Mary Corcoran

Theses

Thiopurine methyltransferase (TPMT) is a cytosolic enzyme that catalyses the S- methylation of aromatic and sulphydryl compounds known as the thiopurines. These therapeutic agents are used in the treatment of acute lymphoblastic leukemia, autoimmune disorders, inflammatory bowel disease and organ transplant recipients.

Erythrocyte TPMT activity is polymorphic and patients with intermediate or deficient TPMT are at significant risk for excessive toxicity after receiving ‘standard’ doses of thiopurine medications. The activity of TPMT is inherited as an autosomal co-dominant trait. Several mutations in the TPMT gene have been described that correlate with a low activity phenotype. Three mutations G238C, G460A and …

Myosin Heavy Chain And Physiological Adaptation Of The Rat Diaphragm In Elastase-Induced Emphysema., Dong Kwan Kim, Jianliang Zhu, Benjamin W Kozyak, James M Burkman, Neal A Rubinstein, Edward B Lankford, Hansell H Stedman, Taitan Nguyen, Sanford Levine, Joseph B Shrager

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

BACKGROUND: Several physiological adaptations occur in the respiratory muscles in rodent models of elastase-induced emphysema. Although the contractile properties of the diaphragm are altered in a way that suggests expression of slower isoforms of myosin heavy chain (MHC), it has been difficult to demonstrate a shift in MHCs in an animal model that corresponds to the shift toward slower MHCs seen in human emphysema. METHODS: We sought to identify MHC and corresponding physiological changes in the diaphragms of rats with elastase-induced emphysema. Nine rats with emphysema and 11 control rats were studied 10 months after instillation with elastase. MHC isoform …

Animal Anti-Apoptotic Genes Ameliorate The Loss Of Turgor In Water-Stressed Transgenic Tobacco, Tala Awada, D. D. Dunigan, M. B. Dickman

Nebraska Center for Virology: Faculty Publications

Nicotiana tabacum L. ‘Glurk’ plants were transformed with antiapoptotic animal genes [chicken Bcl-xl; nematode CED-9; chicken Bcl-xl(GA) a mutant of Bcl-xl; and a 3’ non-coding region of human Bcl-2, referred to as 161-1]. Our objectives were to determine whether plant transformation with anti-apoptotic genes ameliorates drought tolerance in tobacco plants by subjecting the plants to a dry-down period. The non-transformed Glurk and the transgenic Glurk harboring G115, which expresses β-glucuronidase, served as controls. Transformation of tobacco plants with animal anti-apoptotic genes significantly impacted the rates of photosynthesis (A) and stomatal conductance (g_s), but not to the same extent …

Identification Of Novel Domains Within Sox-2 And Sox-11 Involved In Autoinhibition Of Dna Binding And Partnership Specificity, Matthew S. Wiebe, Tamara K. Nowling, Angie Rizzino

Nebraska Center for Virology: Faculty Publications

Sox transcription factors play key regulatory roles throughout development, binding DNA through a consensus (A/T)(A/T)CAA(A/T)G sequence. Although many different Sox proteins bind to this se-quence, it has been observed that gene regulatory elements are commonly responsive to only a small subset of the entire family, implying that regulatory mechanisms exist to permit selective DNA bind-ing and/or transactivation by Sox family members. To identify and explore the mechanisms modu-lating gene activation by Sox proteins further, we compared the function of Sox-2 and Sox-11. This led to the discovery that Sox proteins are regulated differentially at multiple levels, including trans-activation, protein partnerships …

Osmosensitive Taurine Release: Does Taurine Share The Same Efflux Pathway With Chloride And Other Amino Acid Osmolytes?, Rodrigo Franco

School of Veterinary and Biomedical Sciences: Faculty Publications

Swelling subsequent to hyposmotic conditions activates a process of volume regulation present in most cell types. This volume adjustment is accomplished by osmolyte translocation toward the extracellular space to reach a new osmotic equilibrium. Molecules involved in this homeostatic mechanism have been broadly classified into two categories: organic and inorganic osmolytes. Inorganic osmolytes comprise mainly the intracellular ions K⁺ and Cl^–. Cell swelling–induced activation of separate K⁺ and Cl^– channels has been described in most preparations. Organic osmolytes are grouped in three categories: amino acids, polyalcohols, and methylamines. These osmolytes, particularly taurine, are present in …

Role Of Activator Protein-1 In The Down-Regulation Of The Human Cyp2j2 Gene In Hypoxia, Nicole Y. Marden, Eva Fiala-Beer, Shi-Hua Xiang, Michael Murray

School of Veterinary and Biomedical Sciences: Faculty Publications

The cytochrome P450 (CYP) 2J2 arachidonic acid epoxygenase gene was down-regulated at a pre-translational level in human hepatoma-derived HepG2 cells incubated in a hypoxic environment; under these conditions, the expression of c-Jun and c-Fos mRNA and protein was increased. The 5′-upstream region of the CYP2J2 gene was isolated by amplification of a 2341 bp fragment and putative regulatory elements that resembled activator protein-1 (AP-1)-like sequences were identified. From transient transfection analysis, c-Jun was found to strongly activate a CYP2J2–luciferase reporter construct, but co-transfection with plasmids encoding c-Fos or c-Fos-related antigens, Fra-1 and -2, abrogated reporter activity. Using a series …

Mucosal Priming Of Simian Immunodeficiency Virus-Specific Cytotoxic T-Lymphocyte Responses In Rhesus Macaques By The Salmonella Type Iii Secretion Antigen Delivery System, David T. Evans, Li-Mei Chen, Jacqueline Gillis, Kuei-Chin Lin, Brian Harty, Gail P. Mazzara, Ruben O. Donis, Keith G. Mansfield, Jeffrey D. Lifson, Ronald C. Desrosiers, Jorge E. Galán, R. Paul Johnson

School of Veterinary and Biomedical Sciences: Faculty Publications

Nearly all human immunodeficiency virus (HIV) infections are acquired mucosally, and the gut-associated lymphoid tissues are important sites for early virus replication. Thus, vaccine strategies designed to prime virus-specific cytotoxic T lymphocyte (CTL) responses that home to mucosal compartments may be particularly effective at preventing or containing HIV infection. The Salmonella type III secretion system has been shown to be an effective approach for stimulating mucosal CTL responses in mice. We therefore tested ∆phoP-phoQ attenuated strains of Salmonella enterica serovar Typhimurium and S. enterica serovar Typhi expressing fragments of the simian immunodeficiency virus (SIV) Gag protein fused to the …

Method To Detect The Presence Of A Microorganism Or Agent In An Animal, David R. Smith, Laura L. Hungerford, Rodney A. Moxley, Susanne Hinkley, Terry Klopfenstein, Jeff Gray

School of Veterinary and Biomedical Sciences: Faculty Publications

The present invention provides a method to detect the presence of a microorganism or agent in an animal. The method encompasses placement of devices at various locations where the animal resides so as to induce the animal to initiate contact with the device. As a result of this contact, the animal deposits various microorganisms and agents on the device. The device is then tested for the presence of the particular microorganism or agent of interest.

Trichorhinophalangeal Syndrome Type I: A Turkish Case, Mustafa Kendi̇rci̇, Mehmet Keski̇n, Duran Aslan, Abdülhaki̇m Coşkun, Yusuf Özkul

Turkish Journal of Medical Sciences

KENDİRCİ^1, Mehmet KESKİN^1, Duran ARSLAN^1, Abdülhakim COŞKUN^2, Yusuf ÖZKUL^3 ^1Department of Pediatrics, Faculty of Medicine, Erciyes University, Kayseri - Turkey ^2Department of Radiodiagnostics, Faculty of Medicine, Erciyes University, Kayseri - Turkey ^3Department of Genetics, Faculty of Medicine, Erciyes University, Kayseri - Turkey

Measurement Of Urine Albumin Levels With A Monoclonal Antibody Based In-House Elisa, Cemaletti̇n Aybay, Resul Karakuş

Turkish Journal of Medical Sciences

Microalbuminuria is considered to be an early indicator of diabetic nephropathy. We have previously reported the establishment of A-HAlb/98 hybridoma secreting monoclonal antibody that specifically recognizes human serum albumin (HSA). In this report, an in-house enzyme-linked immunosorbent assay (ELISA) was developed using this antibody for the measurement of urinary albumin (UA) and UA was examined in 24 different samples. A-HAlb/98 was used as the capture antibody by immobilizing onto microtitre plates in ELISA format. HSA-specific polyclonal rabbit immunoglobulin was labelled with biotin and then used as the tracer antibody. The dynamic assay range of ELISA for albumin was established to …

Are The Sequence And Level Of The Branches Of The Popliteal Artery Different In The Fetus Than In The Adult?: Two Fetuses With Popliteal Arterial Variation, Zeli̇ha Kurtoğlu, Mustafa Akteki̇n, Ahmet Hakan Öztürk, Cem Kara

Turkish Journal of Medical Sciences

URTOĞLU Mustafa AKTEKİN Ahmet Hakan ÖZTÜRK Cem KARA Department of Anatomy Faculty of Medicine, Mersin University, Mersin - Turkey

Intranasal Encephalocele, Nesri̇n Gürsan, Mehmet Dumlu Aydin, Sare Altaş, Atti̇la Ertaş

Turkish Journal of Medical Sciences

ÜRSAN^1 Mehmet Dumlu AYDIN^2 Sare ALTAŞ^1 Attila ERTAŞ^3 Departments of ^1Pathology, ^2Neurosurgery, Faculty of Medicine, Atatürk University; and ^3Department of Ear-Nose-Throat, Social Security Hospital, Erzurum - Turkey

Saru, A Sara Homolog, Is Repressed By Sart And Regulates Virulence Genes In Staphylococcus Aureus, Adhar C. Manna, Ambrose L. Cheung

Dartmouth Scholarship

In searching the Staphylococcus aureus genome, we previously identified sarT, a homolog of sarA, which encodes a repressor for alpha-hemolysin synthesis. Adjacent but transcribed divergently to sarT is sarU, which encodes a 247-residue polypeptide, almost twice the length of SarA. Sequence alignment disclosed that SarU, like SarS, which is another SarA homolog, could be envisioned as a molecule with two halves, with each half being homologous to SarA. SarU, as a member of the SarA family proteins, disclosed conservation of basic residues within the helix-turn-helix motif and within the beta hairpin loop, two putative DNA binding domains within this protein …

Faculty Publications 2002, Lsu Health Sciences Center New Orleans

Historical Faculty Publications

This Faculty bibliography contains 876 publications.

Environmental Health In Public Health, Steven Konkel

Books/Book chapters

No abstract provided.

Method For Inhibition Of Photocarcinogenesis Or Photoimmunosuppression Using Niacin, Elaine L. Jacobson, Helen L. Gensler

Graduate Center for Nutritional Sciences Faculty Patents

The invention is directed to novel methods for the suppression of photocarcinogenesis and photoimmunosuppression in mice. The novel methods comprises the step of administering to a subject a pharmaceutical composition comprising niacin and a pharmaceutical carrier.

Dose-Response Effects Of Lithium On Spatial Memory In The Black Molly Fish., Thomas Kyle Creson

Electronic Theses and Dissertations

Lithium continues to be widely prescribed for the management of bipolar disease, yet cognitive impairment-related side effects promote noncompliance of the treatment regimen. We have introduced a novel animal model, the black molly fish, to study dose-response effects of lithium on short-term (STM) and long-term (LTM) memories. We developed a method utilizing capillary ion analysis (CIA), to measure plasma and brain lithium levels employed in our behavioral studies. We then developed an appropriate testing environment to ascertain learning capacities of these fish. We established that black mollies could adequately perform a forced-choice spontaneous alternation (SA) task used extensively in rodents …

Activation Of Ca2+-Activated K+ Channels And Cell Migration By Hepatocyte Growth Factor/Scatter Factor In Madin-Darby Canine Kidney Cells., Min Jin

Electronic Theses and Dissertations

Hepatocyte Growth Factor/Scatter Factor (HGF/SF) stimulates migration of various cells and has been linked via Met tyrosine kinase signaling to transformation and the metastatic phenotype. HGF/SF-Met signaling also plays a role in malignancy. Migration of transformed MDCK-F cells depends on activation of a charybdotoxin (ChTX)-sensitive, volume-activated membrane K⁺ current. Patch-clamp electrophysiology and transwell migration assays were used to study the effects of HGF/SF on membrane K⁺ currents and cell migration in MDCK II cells. HGF/SF activated membrane K⁺ currents that increased over 24 hr, and these could be modulated by altering intracellular free calcium concentration [Ca^{2+ …}

Mentha (Lamiaceae) Phylogenetic Analysis Using Chloroplast Trnl-Trnf And Nuclear Ribosomal Dna Its Sequences, Jiranan Bunsawatt

Masters Theses & Specialist Projects

Mentha (Nepetoideae, Lamiaceae) is a taxonomically complex genus that includes economically important members such as spearmint and peppermint and species of global conservation interest. Mentha is considered challenging systematically due to its high incidence of polyploidy, diverse morphology, variation in base chromosome number, and frequent interspecific hybridization. Our objectives were to test the monophyly of Mentha and each of its traditionally recognized sections, assess phylogenetic relationships of the Mentha species, test hypotheses of hybridization for the putative stabilized allopolyploids (M spicata and M. canadensis), and determine the ancestral base chromosome number using DNA sequence data from the chloroplast trnL-trnF and …

Review Of "The Human Embryonic Stem Cell Debate: Science, Ethics, And Public Policy (Basic Bioethics)," Edited By Suzanne Holland, Karen Lebacqz, And Laurie Zoloth, James Steele

The University of New Hampshire Law Review

[Excerpt] "Perhaps like others, I started "The Human Embryonic Stem Cell Debate" not knowing many of the finer points of embryonic stem cell research, but I certainly had an opinion. This issue is far more complex than I had initially imagined. The editors do a commendable effort of compiling a sample of the innumerable arguments surrounding the debate."