Digital Commons Network^™

Effects Of Aerobic Exercise Training On The Heart Rate-Work Rate Relationship And Estimation Of Anaerobic Threshold In Obese Females, Oğuz Özçeli̇k, Haluk Keleşti̇mur

Turkish Journal of Medical Sciences

Aim: The purpose of this study was to assess the effects of aerobic training on the relationship between the heart rate deflection point and anaerobic threshold (AT). Patients and Methods: Seventeen untrained, obese subjects (body mass index: 39.5 ± 1.2 kg/m^2) completed 2 incremental ramp exercise tests (15 W/min) up to the point of exhaustion using an electromagnetically-braked cycle ergometer; once at the onset and once at the end of a 4-week period. All subjects participated in a regular anaerobic exercise training programme (45 min, 3 times per-week, for 4 weeks) combined with a hypocaloric diet. Heart rate was recorded …

Investigation Of Four Different Normality Tests In Terms Of Type 1 Error Rate And Power Under Different Distributions, Derya Öztuna, Ati̇lla Hali̇l Elhan, Ersöz Tüccar

Turkish Journal of Medical Sciences

Background: An important aspect of the "description" of a variable is the shape of its distribution, which tells you the frequency of values from different ranges of the variable. Typically, as most of the statistical tests are based on the normality assumption, a researcher is interested in how well the distribution can be approximated by the normal distribution. Unless there are extreme violations of the normality assumptions, approved statistical tests usually provide accurate results. Although simple descriptive statistics can provide some information relevant to this issue, more precise information can be obtained by performing one of the tests of normality …

Effects Of Direct Tabletting Agents On Drug Release Kinetics And Swelling Behavior Of Hydrophilic Matrix Tablets, Evren Alğin, Müge Kiliçarslan, Ayşegül Karataş, Ni̇lüfer Yüksel, Tamer Baykara

Turkish Journal of Medical Sciences

Aims: This work focused on the effects of direct tabletting agents (DC-agents) (Microcel PH101^®, Cellactose 80^®, Ludipress LCE^®, Pharmatose DCL11^®) and hydroxypropyl-methylcellulose (HPMC) types (Methocel^® K100LV, K15M, K100M) on release of Verapamil HCl from hydrophilic matrix tablets and swelling behaviors of these tablets. Material and Methods: Tablets were prepared by direct compression method. In vitro dissolution and swelling degree tests were performed on the tablets. The release mechanisms of drug were evaluated by using Korsmeyer-Peppas model. Results: While the increase in cellulose content of DC-agents contributed to the swelling of matrices and decreased the release rate of drug from the …

Guillain-Barré Syndrome Due To Hepatitis A, Selçuk Çomoğlu, Mustafa Cesur

Turkish Journal of Medical Sciences

Guillain-Barré syndrome (GBS) is reported frequently following hepatotrophic viruses, but its occurrence due to the hepatitis A virus has been rarely reported to date. We present a case of serologically positive acute hepatitis A infection associated with GBS. There was an increased protein level in the cerebrospinal fluid and prolonged nerve conduction, with minimal axonal damage findings in electromyography.

Treatment Of Habitual Lip Biting: A Case Report, Şeni̇z Karaçay, Günseli̇ Güven, Deni̇z Sağdiç, Feri̇dun Başak

Turkish Journal of Medical Sciences

No abstract provided.

Treatment Of Periapical Dental Implant Pathology With Guided Bone Regeneration, Tolga Fi̇kret Tözüm, Cenk Erdal, Işil Saygun

Turkish Journal of Medical Sciences

Peri-implantitis is the inflammatory process that takes place around alveolar bone surrounding the dental implant. Unless treated, it may result with the loss of the implant. Another cause of the loss of implant is the periapical implant pathology (PIP). Resective surgical procedures are used in the treatment of PIP, however; this case report will provide information about regenarative applications performed on a dental implant. After the referral of the patient, the surgical debridement followed by bone graft and a resorbable membrane application were performed to complete the surgery. Six months follow-up of the patient who received regenerative treatment, resulted with …

Comparison Of The Diagnostic Value Of The Standard Tube Agglutination Test And The Elisa Igg And Igm In Patients With Brucellosis, Mustafa Ertek, Hali̇l Yazgi, Zülal Özkurt, Ahmet Ayyildiz, Mehmet Parlak

Turkish Journal of Medical Sciences

Background and Aims: Brucellosis is endemic in Turkey. Since it affects many organs and the symptoms are non-specific, the diagnosis by clinical findings is difficult and may be easily missed. Many serological tests have been used for the diagnosis of human brucellosis. This study compared the diagnostic value of the Brucella standard tube agglutination test (SAT) with that of ELISA (Brucella specific IgG and IgM) tests in patients with Brucella bacteremia. Patients and Methods: Thirty-two patients with brucellosis who had positive blood and/or bone-marrow cultures for Brucella species, and 20 healthy individuals as controls were included in the study. Results: …

A Non-Erythematous And Depressed Panniculitic Lesion In The Gluteal Region: Lupus Profundus Or Subcutaneous Dermatofibroma?, Mustafa Turhan Şahi̇n, Ayli̇n Türel Ermertcan, Serap Öztürkcan, Peyker Demi̇reli̇

Turkish Journal of Medical Sciences

Turhan ŞAHİN^1 Aylin TÜREL ERMERTCAN^1 Serap ÖZTÜRKCAN^1 Peyker DEMİRELİ^2 ^1Department of Dermatology, Faculty of Medicine, Celal Bayar University, Manisa - TURKEY ^2Department of Pathology, Faculty of Medicine, Celal Bayar University, Manisa - TURKEY

Effects Of Excess Vitamin B_6 Intake On Serum Lipid Profile And Cerebral Cortex In Rats, Göksemi̇n Acar, Leyla Sati, Yasemi̇n Seval, Aysel Ağar, Ramazan Demi̇r

Turkish Journal of Medical Sciences

Aim: The present study was undertaken to investigate the effects of dietary excess of vitamin B_6 on certain blood parameters [serum total cholesterol, high density lipoprotein (HDL) cholesterol and total lipid] and the cerebral cortex. Materials and Methods: A total of 36 albino rats were included in the study. Saline solution was administered to control groups (CG-10, n = 6 for 10 days; CG-15, n = 6 for 15 days; CG-20, n = 6 for 20 days). The experimental groups (EG-10, n = 6; EG-15, n = 6; EG-20, n = 6) received 5 mg/kg vitamin B_6 daily for 10 …

The Effect Of Zinc Deficiency On Zinc Status, Carbohydrate Metabolism And Progesterone Level In Pregnant Rats, Zine Kechrid, Sabrina Amamra, Noureddine Bouzerna

Turkish Journal of Medical Sciences

Aim: Our aim was to investigate the effect of low dietary zinc intake in late gestation on zinc status, transaminases and alkaline phosphatase activities, carbohydrate metabolism and progesterone level in albino (Wistar) rats. Materials and Methods: Eight-week-old female pregnant and non-pregnant albino (Wistar) rats were fed with diets containing either adequate (54 mg/kg) or low zinc (1 mg/kg) quantities for 18 days. Food intakes and body weight gain were recorded regularly. On day 19, after an overnight fast, blood samples were collected and animals dissected. Femur, pancreas, placenta and fetuses were removed. Concentrations of glucose, cholesterol, and urea; transaminases and …

An Experimental Study: Does Topically Applied Sildenafil Citrate (Sildegra®) Have An Effect On The Preservation Of The Viability Of The Graft In Full-Thickness Tubed Free Skin Grafts?, Ali̇ Ayyildiz, K. Turgay Akgül, Bariş Nuhoğlu, Emre Huri̇, Muzaffer Çaydere, Hüseyi̇n Üstün, Cankon Germi̇yanoğlu

Turkish Journal of Medical Sciences

Aim: In this study we investigated the effectiveness of topically applied sildenafil citrate in increasing graft viability. Methods: The study included 15 rats (5 rats each in control, sham, and study groups). Physiological saline (1 ml) was given to the sham group and sildenafil citrate solution (0.5 mg/kg/day in 1 ml saline) to the study group. One week later the grafts were evaluated by histopathological investigation. Results: The feeding tube in the control and sham groups had totally melted due to xylol. Widespread neutrophil leukocyte infiltration, a thin full-thickness free tubed graft in the periphery, widespread neutrophil and inflammation zones …

Success Of Extracorporeal Shock Wave Lithotripsy In Patients With Lower Caliceal Stone And Favorable Anatomy, Sedat Soyupek, Taylan Oksay, Abdullah Armağan, Alper Özorak, Ali̇m Koşar, Hakki Perk

Turkish Journal of Medical Sciences

Aim: We assessed the efficacy of extracorporeal shock wave lithotripsy (ESWL) monotherapy for isolated lower pole nephrolithiasis with favorable anatomy and compared treatment efficacy with regard to different stone sizes. Materials and Methods: From February 1999 to December 2002, adult patients with simple, radiopaque lower pole kidney stones were treated using a Stonelith V3 Lithotriptor (PCK, Turkey). Patients were stratified into four groups based on stone diameter. These groups included stone diameters of =70°, IL5 mm) were included in the study. Results: The overall stone-free rate was 84.5%. The stone-free rates in patient groups according to stone size were 90%, …

Digito-Palmar Complex In Non-Insulin Dependent Diabetes Mellitus, Vadgaonkar Rajanigandha, Pai Mangala, Prabhu Latha, Saralaya Vasudha

Turkish Journal of Medical Sciences

Background: It is only recently that the knowledge of dermatoglyphics has been applied to the field of medical and genetic diagnosis. Aim: The aim of the present study was to compare and evaluate the dermatoglyphic pattern in individuals with non-insulin dependent diabetes mellitus (NIDDM) with a normal adult population. Materials and Methods: Both quantitative as well as qualitative parameters were analyzed in 112 (63 male and 49 female) subjects and compared with the data from 142 (65 male and 77 female) healthy controls. Modified Purvis-Smith ink method was used for obtaining the prints, and statistical analyses were done using Student's …

Laparoscopic Cholecystectomy In The Elderly, I. Oskay Kaya, Alper Özkardeş, Fati̇h Özdemi̇r, Gaye Şeker, Mehmet Tokaç, M. Mahi̇r Özmen

Turkish Journal of Medical Sciences

Aim: Our aim was to evaluate the rate of laparoscopic surgery in elderly patients with gallstones and to compare it with their younger counterparts. The relation between age and the rate of conversion was also evaluated. Materials and Methods: Medical records of the patients who underwent surgery for gallstones during the last six years were evaluated. Patients were divided into two groups according to their age as below and above 65 years. Age, sex, type of operation and rate of conversion were all recorded for both groups and analyzed. Results: There were 1783 patients aged under 65 years in Group …

Cardioembolic Strokes In Eastern Iran And The Importance Of Rheumatic Valvular Disease, Kavian Ghandehari, Zahra Izadi Mood

Turkish Journal of Medical Sciences

Background: Rheumatic valvular disease is a common complication of rheumatic fever in children in developing countries. Later in life, rheumatic valvular disease becomes an important modifiable risk factor of stroke. The incidence of rheumatic valvular disease and its complications are unknown in Iran. Materials and Methods: This is a prospective study of 302 consecutive patients admitted to a tertiary care hospital in Iran with a diagnosis of non-hemorrhagic stroke from June 2003 to June 2005. All patients underwent diagnostic work-up to determine stroke etiology according to clinical indications. Diagnosis and classification of stroke were made according to World Health Organization …

Effect Of Methanolic Extracts Of Artemisia Aucheri And Camellia Sinensis On Leishmania Major (In Vitro), Mehdi Sharif, Hajar Ziaei, Mohammad Azadbakht, Ahmad Daryani, Akbar Ebadattalab, Masoumeh Rostami

Turkish Journal of Medical Sciences

Aim: Infections caused by protozoa of the genus Leishmania are major worldwide health problems with high endemicity in developing countries. The incidence of leishmaniasis has increased in the absence of a vaccine. Usual drugs for treatment of the disease have many side effects; therefore, there is an urgent need to find new effective alternatives. The plant kingdom is a valuable source of new medicinal agents. Methods: In this randomized, one-blind clinical trial, the in vitro leishmanicidal effects of Artemisia aucheri and Camellia sinensis on Leishmania major were evaluated. The methanolic extracts were prepared by percolation method. The extracts were dried …

Trichonamas Vaginalis Infection Among Palestinian Women: Prevalence And Trends During 2000-2006, Adnan Ibrahim Al-Hindi, Abdel Monem Hissein Lubbad

Turkish Journal of Medical Sciences

Aim: Trichomonas vaginalis has not been studied in Gaza and there is no available data on the prevalence of this sexually transmitted disease (STD). The objectives of this study were to determine the prevalence of Trichomonas vaginalis (T. vaginalis) among Palestinian women attending a child and mother care center in Gaza, Palestine and to estimate the trend of prevalence over the period from 2000-2006. Materials and Methods: A cross-sectional descriptive study was conducted among 430 pregnant women attending a child and mother care center in Gaza. The clinical and gynecologic examinations were performed according to the complaints reported by each …

Complications Of Brucella Infection Among Adults: An 18-Year Retrospective Evaluation, Mustafa Ertek, Hali̇l Yazgi, Ayten Kadanali, Kemaletti̇n Özden, Mehmet Akin Taşyaran

Turkish Journal of Medical Sciences

Aim: Brucellosis is a systemic infection in which any organ or system of the body can be involved. We evaluate here complications and involvement of Brucella infection in Erzurum, Turkey. Materials and Methods: We analyzed retrospectively 216 adult (89 female and 127 male) cases of brucellosis who were diagnosed and treated in the Infectious Disease Clinic of Atatürk University Research Hospital from 1985 to 2002. The diagnosis was based on clinical findings and serologic results and/or blood culture confirmations. Results: All isolates from cultures were identified as Brucella melitensis biotype 1. Skeletal complications were the most frequent, found in 147 …

Ethidium Bromide Spot Test Is A Simple Yet Highly Accurate Method In Determining Dna Concentration, Murat Kasap, Si̇nem Torol, Gülçi̇n Gacar, Fatma Budak

Turkish Journal of Medical Sciences

A commonly used method to measure the amount of DNA in nucleic acid preparations is to use UV irradiation. However, if the DNA sample contains impurities, measuring UV irradiation is misleading. A quick way to estimate the amount of DNA in such samples is to analyze spot densities created by UV-induced fluorescence emitted by ethidium bromide. The amount of DNA is proportional to the amount of fluorescence. In many references, the spot density analysis is recommended for rough estimation of DNA concentration and is done by visual examination and comparison of the densities of each spot with the densities of …

The Oncocytic Variant Of Papillary Thyroid Carcinoma, Reşi̇t Doğan Köseoğlu, Nurper Onuk Fi̇li̇z

Turkish Journal of Medical Sciences

Papillary thyroid carcinoma (PTC) has many subtypes. A rare subtype consisting of papillary projections covered by cells oncocytic in character has been defined in recent years. Oncocytes with characteristic nuclear features of PTC are seen in the thyroid aspiration cytology of this subtype. In the cytological diagnosis, this variant could be confused with other oncocytic lesions of the thyroid. We discuss here the cytological and histopathological features of the oncocytic variant of PTC diagnosed in the aspiration biopsy and thyroid resection material in a 42-year-old female patient.

Spinal Anesthesia Management In Central Core Disease: A Case Report, Bi̇nnur Sarihasan, Ebru Kelsaka

Turkish Journal of Medical Sciences

Central core disease is a rare neuromuscular disorder associated with leg weakness. It is a familial disease with autosomal dominant inheritance. Central core disease has been reported to be associated with malignant hyperthermia. A 25-year-old woman with central core disease was scheduled to be operated for lumbar disc hernia at L4-5 and L5-S1 interspaces. Oral dantrolene was administered prophylactically. Spinal anesthesia was performed with a 25 G Whitacre spinal needle at the L3-4 interspace. No complication was observed during the intraoperative and postoperative periods. We present a case with central core disease who was operated under spinal anesthesia with oral …

Acute Isoniazid Intoxication: Convulsion, Rhabdomyolysis And Metabolic Acidosis, Sadi̇ Kerem Okutur, Fati̇h Borlu, Çi̇ğdem Yazici Ersoy, Fatma Paksoy

Turkish Journal of Medical Sciences

Isoniazid is one of the most commonly used antituberculous drugs. Acute intoxication is characterized by repetitious convulsions, high anion gap metabolic acidosis and coma. The basis of therapy consists of parenteral pyridoxine administration in a dose equivalent to that of isoniazid ingested. Here we present a case of acute isoniazid intoxication presenting with convulsions and metabolic acidosis with consequent rhabdomyolysis and discuss the clinical signs and pathophysiology of isoniazid intoxication.

Linking Ligand-Induced Alterations In Androgen Receptor Structure To Differential Gene Expression: A First Step In The Rational Design Of Selective Androgen Receptor Modulators, Dmitri Kazmin, Tatiana Prytkova, C. Edgar Cook, Russell Wolfinger, Tzu-Ming Chu, David Beratan, J. D. Norris, Ching-Yi Chang, Donald P. Mcdonnell

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

We have previously identified a family of novel androgen receptor (AR) ligands that, upon binding, enable AR to adopt structures distinct from that observed in the presence of canonical agonists. In this report, we describe the use of these compounds to establish a relationship between AR structure and biological activity with a view to defining a rational approach with which to identify useful selective AR modulators. To this end, we used combinatorial peptide phage display coupled with molecular dynamic structure analysis to identify the surfaces on AR that are exposed specifically in the presence of selected AR ligands. Subsequently, we …

Cancerous Contradictions: The Mis-Regulation Of Human Carcinogens Based On Animal Data, Andrew Knight, Jarrod Bailey, Jonathan Balcombe

Experimentation Collection

The regulation of human exposures to potential carcinogens constitutes society’s most important use of animal carcinogenicity data. However, for environmental contaminants of greatest U.S. concern, we found that in most cases (58.1%; 93/160) the U.S. Environmental Protection Agency (EPA) considered the animal data inadequate to support a classification of probable human carcinogen or noncarcinogen.

The World Health Organisation’s International Agency for Research on Cancer (IARC) is a leading international authority on carcinogenicity assessments. For chemicals lacking human exposure data (the great majority), IARC classifications of identical chemicals were significantly more conservative than EPA classifications (p

Analysis Of Aahperd Research Abstracts Published Under Special Populations From 1968 To 2004, Jiabei Zhang

Human Performance and Health Education Faculty Research

The purpose of this study was to explore historical research trends in adapted physical activity by analyzing abstracts published under special populations by AAHPERD conventions from 1968 to 2004. There were 562 abstracts retrieved that were coded into seven categories: (a) number of authors, (b) data source, (c) sample size, (d) disability type, (e) data analysis, (f) type of study, and (g) focus of study. The coded data are presented as descriptive statistics and linear regression equations. The results of descriptive statistics describe an overall picture of the knowledge accumulation in adapted physical activity. The results of linear regression equations …

Seroprevalence Of Cytomegalovirus Antibodies In Haemodialysis Patients, Sebahatti̇n Ocak, Ni̇zami̇ Duran, Ali̇ Fuat Eski̇ocak

Turkish Journal of Medical Sciences

Background: Although symptoms of infection caused by cytomegalovirus (CMV) in healthy adults are generally mild, the virus is known to produce severe symptoms most often in immunocompromised patients. Patients with chronic renal failure are prone to CMV infection. CMV, as a nosocomial infection in immunocompromised patients, is a problem for clinicians. Aim: We aimed to investigate the seroprevalence of CMV infection among the haemodialysis (HD) patients in our region. Patients and Methods: Serum samples were taken from 255 patients who received treatment in 3 different HD clinics and a control group of 70 healthy persons. Enzyme-linked immunosorbent assay (ELISA) was …

Monoclonal Antibodies To Distinct Regions Of Human Myelin Proteolipid Protein Simultaneously Recognize Central Nervous System Myelin And Neurons Of Many Vertebrate Species, Edward A. Greenfield, Jay Reddy, Andrew Lees, Charissa A. Dyer, Omanand Koul, Khuong Nguyen, Shannon Bell, Nasim Kassam, Julian Hinojoza, Mary Jane Eaton, Marjorie B. Lees, Vijay K. Kuchroo, Raymond A. Sobel

Jay Reddy Publications

Myelin proteolipid protein (PLP), the major protein of mammalian CNS myelin, is a member of the proteolipid gene family (pgf). It is an evolutionarily conserved polytopic integral membrane protein and a potential autoantigen in multiple sclerosis (MS). To analyze antibody recognition of PLP epitopes in situ, monoclonal antibodies (mAbs) specific for different regions of human PLP (50–69, 100–123, 139–151, 178–191, 200–219, 264–276) were generated and used to immunostain CNS tissues of representative vertebrates. mAbs to each region recognized whole human PLP on Western blots; the anti-100–123 mAb did not recognize DM-20, the PLP isoform that lacks residues 116–150. All of …

Diverse Roles Of Pkcα In Vascular Smooth Muscle Contraction, Ava Caudill Dykes

Theses, Dissertations and Capstones

A complete understanding of the mechanisms underlying smooth muscle contractility has proven elusive due to the many interacting factors thought to influence contractile behavior in this muscle type. One such factor, protein kinase Cα (PKCα), is proposed to play a central role in both the activation and modulation of smooth muscle contraction. PKCα is activated through a G-protein coupled receptor and is subsequently translocated to its site of action. Although the mechanisms regulating PKCα site specific translocation are not completely understood, it is thought that this process is essential for PKCα specificity of action within the cell. In chapter II …

Arterial Blood Pressure Monitoring In Overweight Critically Ill Patients: Invasive Or Noninvasive?, Ali Araghi, Joseph J. Bander, Jorge A. Guzman

Wayne State University Associated BioMed Central Scholarship

Abstract

Introduction

Blood pressure measurements frequently guide management in critical care. Direct readings, commonly from a major artery, are considered to be the gold standard. Because arterial cannulation is associated with risks, alternative noninvasive blood pressure (NIBP) measurements are routinely used. However, the accuracy of NIBP determinations in overweight patients in the outpatient setting is variable, and little is known about critically ill patients. This prospective, observational study was performed to compare direct intra-arterial blood pressure (IABP) with NIBP measurements obtained using auscultatory and oscillometric methods in overweight patients admitted to our medical intensive care unit.

Method

Adult critically ill …

A Database And Tool, Im Browser, For Exploring And Integrating Emerging Gene And Protein Interaction Data For Drosophila, Svetlana Pacifico, Guozhen Liu, Stephen Guest, Jodi R. Parrish, Farshad Fotouhi, Russell L. Finley Jr

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Biological processes are mediated by networks of interacting genes and proteins. Efforts to map and understand these networks are resulting in the proliferation of interaction data derived from both experimental and computational techniques for a number of organisms. The volume of this data combined with the variety of specific forms it can take has created a need for comprehensive databases that include all of the available data sets, and for exploration tools to facilitate data integration and analysis. One powerful paradigm for the navigation and analysis of interaction data is an interaction graph or map that represents proteins …