Digital Commons Network^™

Case Of Tuberous Sclerosis With Pulmonary Involvement, Arzu Balkan, Cantürk Taşci, Carl R. Fuhrman

Turkish Journal of Medical Sciences

Tuberous sclerosis is a rare genetic disorder. The diagnosis of tuberous sclerosis requires the presence of two major or one major and two minor features. Pulmonary involvement has been reported to occur in less than 1% in patients and carries a poor prognosis. We present a female tuberous sclerosis patient with pulmonary involvement, evaluated for a positive PPD reaction.

Diagnostic Neglect Regarding Ureter Ligation After Hysterectomy, Yaşar Bi̇lge

Turkish Journal of Medical Sciences

Complications following cesarean and hysterectomy operations can occur, one of which is ureter ligation. Aims: Urological injuries that occur during hysterectomy are rare but important causes of morbidity. It was aimed to investigate in this case report whether there was any evidence to support malpractice in Court. Case Report: The patient was a woman in her 34^3 week of pregnancy with familial Mediterranean fever (FMF) and nephrotic syndrome with renal amyloidosis. Preterm operational diagnosis was placenta previa totalis and repeat cesarean section was performed with confirmed consent. When the placenta spontaneously ruptured, hysterectomy was undertaken. Ureter ligation with acute renal …

Sacral Chondroblastic Osteosarcoma Misdiagnosed As Chondrosarcoma And Chordoma, Nusret Akpolat, Hanefi̇ Yildirim, Kürşat Poyraz

Turkish Journal of Medical Sciences

Chondroblastic osteosarcoma (COS), a subgroup of intramedullary osteosarcoma, is usually located in the knee region of the body. It is most common in adolescents and early adulthood. COS has similar clinical and radiological features to those of conventional osteosarcomas. A 17-year-old male suffered from walking problems and lower limb pain. CT and MRI revealed a mass with soft tissue density and bone destruction at the level of L5-S1. It was described as \"posttraumatic hematoma\". In cytopathologic examination, initial diagnosis was chordoma in fine-needle aspiration cytology (FNAC), chondrosarcoma in incisional biopsy, and finally COS in total resection specimen. Because sacral location …

How Should Glucocorticoids Be Used?, Şi̇nasi̇ Özsoylu

Turkish Journal of Medical Sciences

No abstract provided.

Quality Assurance Standards Task Force Global Standards: Route For Accreditation In Medical Education In Europe, İskender Sayek, Hans Karle

Turkish Journal of Medical Sciences

No abstract provided.

Interleukin-6 And Nitric Oxide Levels In Neonatal Sepsis, Anil Aktaş Tapisiz, Ebru Ergenekon, Deni̇z Erbaş, Murat Öktem, Ni̇hal Demi̇rel, Kivilcim Gücüyener, Canan Türkyilmaz, Esra Önal, Yildiz Atalay

Turkish Journal of Medical Sciences

Aim: The objectives of this study were to compare interleukin-6 (IL-6) and nitric oxide (NO) levels in newborns with culture-proven sepsis with levels in age- and gestational age (GA)-matched controls, and to investigate the correlation between mediator levels and circulatory functions in the septic group. Materials and Methods: Samples for IL-6 and NO levels were obtained from newborns with blood culture-proven sepsis before the beginning of antibiotic therapy and on the 3rd day of treatment. Heart rate, blood pressure and other treatment modalities including inotropic support were also recorded. Age- and GA-matched newborns without infection were included as controls. Minitab …

Plasma Thrombin Activitable Fibrinolysis Inhibitor Levels In Behçet´S Disease, Mehmet Ali̇ Özcan, Servet Akar, İnci̇ Alacacioğlu, Özden Pi̇şki̇n, Fai̇ze Yüksel, Oğuz Gürler, Nurullah Akkoç, Fati̇h Demi̇rkan, Güner Hayri̇ Özsan, Şebnem Özkan, Fatoş Önen, Bülent Ündar

Turkish Journal of Medical Sciences

Aim: The precise pathogenetic mechanisms causing thrombotic complications in Behçet´s disease (BD) are still not known. To explain the pathogenesis with coagulation induction or a defective fibrinolysis superimposed on endothelial dysfunction, various hemostatic parameters were studied. Thrombin activatable fibrinolysis inhibitor (TAFI), downregulating plasmin generation and fibrinolysis, is a novel risk factor for thrombotic disorders. We studied plasma TAFI levels in BD in comparison with healthy controls. Materials and Methods: Twenty-three patients with BD (mean age: 38.3 ± 10.83, M/F: 5/18) diagnosed according to the criteria of the International Study Group and 20 healthy volunteers (mean age: 38.05 ± 6.29, M/F: …

Effects Of Acute Fenthion Toxicity On Liver And Kidney Function And Histology In Rats, Mustafa Kerem, Nurdan Bedi̇rli̇, Nesli̇han Gürbüz, Özgür Eki̇nci̇, Abdulkadi̇r Bedi̇rli̇, Taylan Akkaya, Ömer Şakrak, Hati̇ce Paşaoğlu

Turkish Journal of Medical Sciences

Aim: The aim of this study was to investigate the dose-related effects of fenthion on the liver and kidney and the correlation between severity of organ damage and serum butyrylcholinesterase (BChE) enzyme levels. Materials and Methods: Ninety rats were randomly subdivided into control group and 4 study groups. Control group was administered 1 ml of saline intraperitoneally. Study groups received 25, 50, 75 and 100 mg/kg of fenthion, intraperitoneally. Blood samples and renal and hepatic tissues were collected 24 h after dosing and survival was monitored for 7 days. Results: Mortality was observed in 2 rats receiving 75 mg/kg fenthion …

Effects Of Esmolol On Hemodynamic Responses To Laryngoscopy And Tracheal Intubation In Diabetic Versus Non-Diabetic Patients, Taner Taşyüz, İsmet Topçu, Sabri̇ Özaslan, Melek Sakarya

Turkish Journal of Medical Sciences

Aim: We aimed to investigate the efficiency of esmolol, a short-acting ß-blocker, in preventing the hemodynamic response to laryngoscopy and endotracheal intubation in diabetic patients. Materials and Methods: Eighty diabetic or non-diabetic patients with ASA physical status I-II scheduled for noncardiac surgery were included in this study. They were divided randomly into 4 groups (Non-diabetic control: NDC, Non-diabetic esmolol: NDE, Diabetic control: DC, Diabetic esmolol: DE). Blood glucose analyses were measured in the preoperative period and at the 10^{th} min of the study. Prior to anesthetic induction, 1 mg/kg esmolol to Groups NDE and DE and saline to Groups NDC …

Prevalence Of Lower Urinary Tract Symptoms In Men Over 40 Years: A Cross-Sectional Study In Samsun, Ahmet Tevfi̇k Sünter, Ci̇had Dündar, Sevgi̇ Canbaz, Sennur Dabak, Yildiz Pekşen

Turkish Journal of Medical Sciences

Aim: Lower urinary tract symptoms (LUTS) are a common problem in ageing men. The aim of this study was to estimate the prevalence of LUTS, as measured by the International Prostate Symptom Score (IPSS), and to establish the relationship between the IPSS and quality of life (QoL) in different age groups of men over 40 years old living in Samsun city center in northern Turkey. Materials and Methods: In all, 1860 men aged over 40 years were included in this cross-sectional study. The Turkish version of the IPSS was applied to all participants using face-to-face interview. Results: The median IPSS …

Is There A Correlation Between Extroversion Personality Characteristics Of Medical Students And Awareness Of Works Of Art?, Sare Alkan, Musaci̇de Zehra Ordulu, Yi̇ği̇t Sezer, Emi̇n Soyer, Di̇lek Aslan, İskender Sayek

Turkish Journal of Medical Sciences

Aim: In this study, we aimed to assess the relation between extroversion personality characteristics and awareness of works of art among a group of university students. Materials and Methods: One hundred thirty-five phase II students of the Medical Faculty of Hacettepe University registered in the 2005-2006 academic year participated in this descriptive study. In order to assess extroversion personality characteristics, Eysenck Extroversion Personality Scale was used. For determining awareness of works of art on the campus, researchers photographed selected works of arts and presented them for evaluation by the participants in a questionnaire. Four categories were determined as follows: category …

Anesthesia For An Adult Patient With Congenital Diaphragmatic Eventration, Hale Yarkan Uysal, Solmaz Günal, Ahmet Ş. Uyar, Hülya Başar

Turkish Journal of Medical Sciences

Congenital diaphragmatic eventration is an uncommon condition in adults and is defined as an abnormal elevation of the diaphragm. In adults, diaphragmatic eventration causes respiratory impairment that is associated with severe dyspnea, orthopnea and hypoxia. Most of the symptomatic patients may survive with supportive therapy without any need for surgical correction, though they are at risk of spontaneous diaphragm rupture. Spontaneous diaphragmatic rupture may develop in a patient with diaphragmatic eventration as a result of any event that leads to increase in intraabdominal pressure. In this case report, we present the anesthetic management of an adult patient with congenital diaphragmatic …

A Real-Time Transthoracic Echocardiographic Imaging Of Pulmonary Embolism In A Patient With Suspected Primary Antiphospholipid Syndrome, Hasan Kocatürk, M. Cengi̇z Çolak, Mustafa Yilmaz, Ednan Bayram, Sebahatti̇n Ateşal

Turkish Journal of Medical Sciences

Clinical manifestations of antiphospholipid syndrome (APS) include repeated episodes of arterial and/or venous thrombosis, recurrent fetal wastage, and premature births. Correct diagnosis of APS requires identification of lupus anticoagulant (LA) and anticardiolipin antibodies (aCL). Other antibodies such as anti-b2 glycoprotein-I have also been detected. A 32-year-old man presented with acute left-sided hemiplegia and was admitted with a possible diagnosis of primary APS. A pulmonary embolus-in-transit was captured incidentally by transthoracic echocardiographic study.

Effect Of Different Drugs Influencing Monoamine Neurotransmission On Haloperidol-Induced Catalepsy In Mice, Omar Mohamed Abdel-Salam, Ayman Ragab Baiuomy

Turkish Journal of Medical Sciences

Aim: Catalepsy occurs following high dopamine D2 receptor blockade by the typical antipsychotic drug haloperidol. The present study investigated the effect of different drugs affecting monoamine neurotransmission in this animal model of Parkinson's disease in mice. Materials and Methods: Drugs were intraperitoneally administered with haloperidol 30 min prior to testing. Catalepsy was measured using the bar test. Results: Catalepsy duration was reduced by the non-selective noradrenaline and serotonin reuptake inhibitors imipramine and amitriptyline (21.1% and 22.3% reduction by 20 mg/kg imipramine and amitriptyline, respectively). Catalepsy duration was increased by the selective serotonin reuptake inhibitors (SSRIs) fluoxetine, fluvoxamine, and citalopram and …

Cryptosporidiosis Among Children Attending Al-Nasser Pediatric Hospital, Gaza, Palestine, Adnan Ibrahim Al-Hindi, Abdelraouf A. Elmanama, Kamal Jad Allah Elnabris

Turkish Journal of Medical Sciences

Aim: The present study was undertaken to determine the prevalence of cryptosporidiosis in patients with diarrhea who attended Al-Nasser Pediatric Hospital in Gaza. Materials and Methods: From January to May 2005, single stool specimens from each of 416 children attending Al-Nasser Hospital were examined by Ziehl Neelsen (ZN) stain and ELISA for the presence of Cryptosporidium oocysts. Results: Cryptosporidium oocysts were detected in 62 (14.9%) of the tested specimens by acid-fast staining technique and in 68 (16.3%) using ELISA kit. The number of infected females was found to be significantly higher than males (P = 0.03). The highest number of …

Effect Of Montelukast Treatment On Serum Paraoxonase Activity In Asthmatic Children, Murat Can, A. Görkem Mungan, Şerefden Açikgöz, Bi̇rol Yüksel, Selda Demi̇rtaş, Nazan Tomaç

Turkish Journal of Medical Sciences

Montelukast, widely used in the treatment of asthma, is a selective and potent oral cysteinyl leukotriene-1 receptor antagonist. In this study, we investigated the effects of montelukast on oxidative stress and antioxidant defense in childhood asthma by measuring malondialdehyde and the paraoxonase activity. Twenty-five children with mild to moderate atopic asthma and 25 nonatopic children as controls were enrolled in the study. Asthmatic children were treated with montelukast, 5 mg tablets, for one month. Serum paraoxonase, malondialdehyde and high-density lipoprotein (HDL) cholesterol levels were measured before and after treatment. Serum paraoxonase and paraoxonase/HDL ratios were significantly increased after montelukast treatment. …

New Replacement Of A Thrombosed Mitral Valve Via Right Anterolateral Thoracotomy In A Patient With Coronary Artery By-Pass Graft And Functioning Internal Mammary Artery Graft, Münacetti̇n Cevi̇z, Neci̇p Beci̇t, Bi̇lgehan Erkut, Hi̇kmet Koçak

Turkish Journal of Medical Sciences

A 49-year-old male, who had undergone mitral valve replacement with mechanical cardiac valve and coronary arterial by-pass grafting six years previously, was admitted to our hospital with acute dyspnea. Transesophageal echocardiography revealed that one of the leaflets of the prosthetic valve was entirely immobilized in the closed position, and an immobile soft tissue mass was detected on the ventricular side of the obstructed leaflet. We performed re-replacement using a 29-mm mechanical prosthetic St. Jude valve under deep hypothermic circulatory arrest via right atrial thoracotomy. Postoperative course was uneventful, and the patient was discharged with oral anticoagulant therapy on day 7 …

Left Atrial Myxoma And Trichilemmal Cysts, Hasan Kocatürk, M. Cengi̇z Çolak, Hi̇kmet Koçak

Turkish Journal of Medical Sciences

A 56-year-old man had a 6 x 5-cm mass originating from the fossa ovalis in the atrial septum found by echocardiography and multiple enlarging scalp masses. The mass had a regular surface and was prolapsing into the mitral valve during diastole. The tumor was successfully treated by surgical excision, which revealed a well-defined mass with a narrow-base stalk originating from the fossa ovalis in the atrial septum. Histological examination confirmed the diagnosis of myxoma. The scalp masses were also removed surgically; histopathologic examination corresponded to benign trichilemmal cyst. The patient recovered without complication and was discharged 10 days after the …

An Impulse Control Disorder Case With Penile Fracture And Trichotillomania, Bi̇rgül Elbozan Cumurcu, Burhanetti̇n Kaya, Feryal Çam Çeli̇kel, Ahmet Soylu, Fi̇kret Erdemi̇r

Turkish Journal of Medical Sciences

Penile fractures are classically described as presenting with rapid detumescence of an erection associated with blunt trauma. This clinical finding is due to a tear in the tunica albuginea surrounding the corpora cavernosum. In this study, we report and discuss a case of trichotillomania and penile bending impulse resulting in penile fracture, which was operated in the urology clinic. The possible psychological and psychiatric problems underlying the impulsive behavior are discussed, and the value of a psychiatric evaluation is emphasized.

The Endogenous Cannabinoid Anandamide Inhibits Cromakalim-Activated K+ Currents In Follicle-Enclosed Xenopus Oocytes, Murat Oz, Keun-Hang Susan Yang, Meral Dinc, Toni S. Shippenberg

Mathematics, Physics, and Computer Science Faculty Articles and Research

The effect of the endogenous cannabinoid anandamide on K+ currents activated by the ATP-sensitive potassium (KATP) channel opener cromakalim was investigated in follicle-enclosed Xenopus oocytes using the two-electrode voltage-clamp technique. Anandamide (1–90 μM) reversibly inhibited cromakalim-induced K+ currents, with an IC50 value of 8.1 ± 2 μM. Inhibition was noncompetitive and independent of membrane potential. Coapplication of anandamide with the cannabinoid type 1 (CB1) receptor antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboximide hydrochloride (SR 141716A) (1 μM), the CB2 receptor antagonist N-[(1S)endo-1,3,3-trimethyl bicyclo heptan-2-yl]-5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-pyrazole-3-carboxamide (SR144528) (1 μM), or pertussis toxin (5 μg/ml) did not alter the inhibitory effect of anandamide, suggesting that known cannabinoid receptors …

Comparison Of The Antibacterial Effects Of Two Local Anesthetics: Lidocaine And Articaine, Kadi̇r Kaya, Seyyal Rota, Bora Doğan, Gi̇zem Kökten, Berri̇n Günaydin, Gülendam Bozdayi

Turkish Journal of Medical Sciences

Aim: The antibacterial effect of lidocaine has been studied widely, but the effect of articaine has not yet been evaluated. We aimed to investigate whether commercially available articaine possesses bactericidal or bacteriostatic effect in comparison with lidocaine in a prospective laboratory setting. Materials and Methods: The antibacterial effects of articaine and lidocaine were studied on Pseudomonas aeruginosa ATCC27853, Staphylococcus aureus ATCC25923, Escherichia coli ATCC35218, and Proteus mirabilis ATCC7002 strains and a patient isolate of Serratia marcescens. For this study, 2% lidocaine HCl and articaine HCl were diluted to 10, 5, 2.5, 1.25, 0.625, 0.312, 0.156, and 0.078 mg ml^{-1} concentrations …

Visualizing The Function And Migration Of T Cells, Kari J. Dugger

All ETDs from UAB

Lymphocytes are highly mobile cells that can travel throughout the body in response to a multitude of stimuli. Identifying lymphocyte trafficking patterns in vivo is essential for a complete understanding of immune function. Cell-cell and cell-tissue interactions in immune development and in lymphocyte response to stimuli can be comprehended with these investigations. Although the location of cell populations in various tissues at any given point in time may be investigated by techniques such as flow cytometry and immunofluorescence, these methods are not easily used in the assessment of dynamic cell migration patterns in vivo. In the past years, technologies for …

The Role Of Chloride In The Volume Regulation Of Human Glioma Cells, Nola Jean Ernest

All ETDs from UAB

According to the Central Brain Tumor Registry of the United States, the most common primary brain tumors are gliomas, tumors composed of cells of glial origin, most commonly astrocytes and oligodendrocytes. The most aggressive of these tumors are characterized by hyperproliferation, marked cellular and nuclear atypia, extensive infiltration into surrounding normal brain tissue, and large areas of cell and tissue death. Previous data published by our lab and others suggest that these biological processes may involve regulated cell volume changes. Using cell volume regulation in the presence of an anisosmotic challenge as a model for cell swelling and shrinkage, cell …

The Substituted Pyrrole Jb-03-14 Induces Autophagic Cell Death And Growth Arrest In Breast Tumor Cells, Christopher Ryan Arthur

Theses and Dissertations

The use of chemotherapy in the treatment of cancer has stimulated the demand for better chemotherapeutic agents that are more potent at destroying tumor cell populations and more selective for the specific tumor versus normal host tissues. This project is directed at discovering new anti-tumor agents that are effective against breast cancer based on structures derived from marine organisms, specifically brominated pyrroles. We utilized an in vitro breast cancer model to study the effects of pyrroles on tumor proliferation and survival, as well as growth arrest and cell death. Our findings indicate that the substituted pyrrole JG-03-14 induces time dependent …

The Quantitative Genetics Of Neurodevelopment: A Magnetic Resonance Imaging Study Of Childhood And Adolescence, James Eric Schmitt

Theses and Dissertations

Understanding the causes of individual differences in brain structure may give clues about the etiology of cognition, personality, and psychopathology, and also may identify endophenotypes for molecular genetic studies on brain development. We performed a comprehensive statistical genetic study of anatomic neuroimaging data from a large pediatric sample (N=600+) of twins and family members from the Child Psychiatry Branch at the NIMH. These analyses included variance decomposition of structural volumetric endophenotypes at several levels of resolution, voxel-level analysis of cortical thickness, assessment of gene by age interaction, several multivariate genetic analyses, and a search for genetically-mediated brain-behavioral relationships. These analyses …

The Effect Of Walnuts Compared To Fatty Fish On Plasma And Erythrocyte Fatty Acid Composition, Lymphocyte Subsets And Inflammatory Mediators, Yu-Lan Ching

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to compare the effects of walnuts vs. fatty fish on circulating inflammatory markers, on lymphocyte subsets, on plasma concentrations of eicosanoids precursor polyunsaturated fatty acid and on erythrocyte membrane fatty acid composition. Under controlled metabolic feeding conditions and randomized crossover (3x3 Latin-square) design, 27 subjects alternately consumed a control diet, a walnut diet (1.5 oz (42.5g) /day of walnuts, 6 times/week) or a fish diet (8 oz (226g) /week of salmon) for 4 weeks each. Consumption of the walnut diet (ALA 5.43 g/day) compared to the fish diet (EPA 170 mg/day and DHA 590 …

Department Of Pathology, Thomas Jefferson University, Identification Of Conserved Gene Expression Features Between Murine Mammary Carcinoma Models And Human Breast Tumors., Jason I Herschkowitz, Karl Simin, Victor J Weigman, Igor Mikaelian, Jerry Usary, Zhiyuan Hu, Karen E Rasmussen, Laundette P Jones, Shahin Assefnia, Subhashini Chandrasekharan, Michael G Backlund, Yuzhi Yin, Andrey I Khramtsov, Roy Bastein, John Quackenbush, Robert I Glazer, Powel H Brown, Jeffrey E Green, Levy Kopelovich, Priscilla A Furth, Juan P Palazzo, Olufunmilayo I Olopade, Philip S Bernard, Gary A Churchill, Terry Van Dyke, Charles M Perou

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

BACKGROUND: Although numerous mouse models of breast carcinomas have been developed, we do not know the extent to which any faithfully represent clinically significant human phenotypes. To address this need, we characterized mammary tumor gene expression profiles from 13 different murine models using DNA microarrays and compared the resulting data to those from human breast tumors. RESULTS: Unsupervised hierarchical clustering analysis showed that six models (TgWAP-Myc, TgMMTV-Neu, TgMMTV-PyMT, TgWAP-Int3, TgWAP-Tag, and TgC3(1)-Tag) yielded tumors with distinctive and homogeneous expression patterns within each strain. However, in each of four other models (TgWAP-T121, TgMMTV-Wnt1, Brca1Co/Co;TgMMTV-Cre;p53+/- and DMBA-induced), tumors with a variety of …

Silencing Of The Pink1 Gene Expression By Conditional Rnai Does Not Induce Dopaminergic Neuron Death In Mice., Hongxia Zhou, Björn H Falkenburger, Jörg B Schulz, Kim Tieu, Zuoshang Xu, Xu Gang Xia

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Transgenic RNAi, an alternative to the gene knockout approach, can induce hypomorphic phenotypes that resemble those of the gene knockout in mice. Conditional transgenic RNAi is an attractive choice of method for reverse genetics in vivo because it can achieve temporal and spatial silencing of targeted genes. Pol III promoters such as U6 are widely used to drive the expression of RNAi transgenes in animals. Tested in transgenic mice, a Cre-loxP inducible U6 promoter drove the broad expression of an shRNA against the Pink1 gene whose loss-of-functional mutations cause one form of familial Parkinson's disease. The expression of the shRNA …

Electrostatic Charge Polarity Effect On Respiratory Deposition In The Glass Bead Tracheobronchial Airways Model, Mohammed Ali, Malay K. Mazumder, Rama N. Reddy, Mariofanna Milanova, Jing Zhang, Alexandru S. Biris

Journal of the Arkansas Academy of Science

The effects of unipolar and bipolar electrostatic charges on the deposition efficiency of therapeutic aerosols in the physical model of human tracheobronchial (TB) airways have been investigated. Respirable size aerosol particles were generated by a commonly prescribed and commercially available nebulizer and charged by a corona charger and then their size and charge distributions were characterized by an Electronic Single Particle Aerodynamic Relaxation Time analyzer to study the drug aerosol particles' deposition pattern. The experiments were performed with a glass bead tracheobronchial model (GBTBM) (physical model) which was designed and developed based upon widely used and adopted dichotomous lung morphometric …

Sustained Il-6/Stat-3 Signaling In Cholangiocarcinoma Cells Due To Socs-3 Epigenetic Silencing., Hajime Isomoto, Justin L. Mott, Shogo Kobayashi, Nathan W. Werneburg, Steve F. Bronk, Serge Haan, Gregory J. Gores

Journal Articles: Biochemistry & Molecular Biology

BACKGROUND & AIMS: Interleukin 6 (IL-6)-mediated signal transducers and activators of transcription 3 (STAT-3) phosphorylation (activation) is aberrantly sustained in cholangiocarcinoma cells resulting in enhanced myeloid cell leukemia 1 (Mcl-1) expression and resistance to apoptosis. Because suppressor of cytokine signaling 3 (SOCS) controls the IL-6/STAT-3 signaling pathway by a classic feedback loop, the aims of this study were to examine SOCS-3 regulation in human cholangiocarcinoma.

METHODS: SOCS-3 expression was assessed in human cholangiocarcinoma tissue and the Mz-ChA-1 and CCLP1 human cholangiocarcinoma cell lines.

RESULTS: An inverse correlation was observed between phospho-STAT-3 and SOCS-3 protein expression in cholangiocarcinoma. In those cancers …