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The Effect Of Caffeic Acid Phenethyl Ester On Bacterial Translocation And Intestinal Damage After Intestinal Obstruction, Cengi̇z Ara, Abuzer Di̇ri̇can, Seli̇m Erdoğan, Burhan Ateş, Di̇nçer Özgör, Fai̇k Tatli, M. Sai̇t Tekerekoğlu, Vedat Kirimlioğlu

Turkish Journal of Medical Sciences

Intestinal obstruction (IO) induces bacterial translocation due to failure of the intestinal barrier function. Following bacterial overgrowth, its degradation products play a decisive role in the development of systemic septic complications. The aim of this study was to evaluate the effects of caffeic acid phenethyl ester (CAPE) on bacterial translocation and intestinal damage in an IO model in rats. Materials and methods: Complete IO was created in the distal ileum of rats by a single 4-0 silk suture. A total of 21 Wistar albino rats were randomized into 3 groups: Group 1, Sham (n = 7); Group 2, IO (n …

Reliability Of Self-Reported History In Predicting Immunity Against Measles, Rubella, Mumps, And Varicella Among Health Care Workers, Çi̇gdem Ataman Hati̇poğlu, Ferah Ergi̇n, Günay Tuncer Ertem, Cemal Bulut, Ruki̇ye Berkem, Ali̇ Pekcan Demi̇röz

Turkish Journal of Medical Sciences

To determine the immunity of health care workers (HCWs) against measles, rubella, mumps, and varicella infections, and to evaluate the reliability of self-reported history of the disease in predicting immunity. Materials and methods: A self-reported questionnaire was used to obtain the history of the diseases and ELISA to screen specific IgG antibodies. The history of the diseases was compared with serological testing results. Results: Eighty-one HCWs were included in the study. Immunity against measles was 97.5%, rubella 100%, mumps 72.8%, and varicella 96.3%. Positive predictive values of positive histories of the diseases were 100% for measles and rubella, 96.5% for …

Assessment Of Procalcitonin And Other Inflammatory Markers In Peritoneal Dialysis-Related Peritonitis*, Reyhan Öztürk, Gül R. Yilmaz, Cemal Bulut, Hülya Parpucu, Sami̇ Kinikli, Murat Duranay, Ali̇ Pekcan Demi̇röz

Turkish Journal of Medical Sciences

It is demonstrated that in end-stage renal failure without an infectious pathology conventional laboratory parameters such as erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) or other acute-phase proteins increase non-specifically. We aimed to evaluate procalcitonin (PCT) and other inflammatory markers such as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) in patients with continuous ambulatory peritoneal dialysis (CAPD)-related peritonitis. Materials and methods: A case-control study was conducted in a 600-bed tertiary hospital. Fifty patients with CAPD-related peritonitis constituting the study group and 50 CAPD patients without infection as the control group were included in the study between February 2006 …

Expression Of Ck-19, Cerbb2, Galectin-3, And P53 In Papillary Thyroid Carcinomas, Selda Seçki̇n, Ülker Karagece

Turkish Journal of Medical Sciences

To determine the immunohistochemical expression of CK-19, cErbB2, galectin-3, and p53 in papillary thyroid carcinomas (PTC). Materials and methods: In this study immunohistochemistry was performed on 23 papillary carcinomas (PCs) and 20 papillary microcarcinomas (PMCs). The extents of staining and intensity were scored semiquantitatively. Results: Of the PC cases 56.5% and of the PMC cases 15.0% were stained strongly by cErbB2. The extent of 2+ staining by galectin-3 was 47.8% in PC, whereas it was only 10.0% in PMC (P = 0.003). All PMC cases were stained by CK-19 and 21 cases of PC expressed positivity in varying extent of …

Underlying Diseases Of Recurrent Pneumonia In Turkish Children*, Osman Özdemi̇r, Si̇nan Sari, Arzu Bakirtaş, Peli̇n Zorlu, Ülker Ertan

Turkish Journal of Medical Sciences

The aim of the present study was to determine the relative frequency of recurrent pneumonia in children and to describe its underlying illnesses. Materials and methods: Children between 3 months and 16 years old who had a history of 2 or more episodes of pneumonia per year, or 3 or more episodes in a lifetime were investigated retrospectively at Doctor Sami Ulus Children's Training and Research Hospital between January 2002 and December 2004. Results: Out of 595 children admitted for pneumonia, 62 (10.42%) met the criteria for recurrent pneumonia. An underlying illness was demonstrated in 56 patients (90.32%). In this …

Can Dynamic Multidetector Computerized Tomography Detect Renal Cell Carcinoma Subtypes?, Ayhan Di̇ri̇m, Ni̇hal Tutar, Levent Peşki̇rci̇oğlu, Hüseyi̇n Çeli̇k, Mehmet İlteri̇ş Teki̇n, Hakan Özkardeş

Turkish Journal of Medical Sciences

To evaluate the efficacy of the biphasic and triphasic dynamic multidedector computerized tomography (MDCT) in the preoperative prediction of histological subtypes of renal cell carcinoma (RCC). Materials and methods: The preoperative dynamic MDCT findings of 51 patients with renal mass who had undergone nephrectomy were reviewed retrospectively. Twenty-five of the patients had biphasic (portal and excretory) and 26 had triphasic (arterial, portal, and excretory) MDCT images. Tumor size, presence of calcification, tumor-aorta attenuation values in all phases and homogeneicity of the tumor were noted for every patient. In heterogeneous tumors, the minimum and maximum attenuation values were noted to determine …

Investigation Of The Causative Agents For Community-Acquired Pneumonia In Adult Patients, Yasemi̇n Zer, Nazan Bayram, İclal Balci, Ayten Fi̇li̇z

Turkish Journal of Medical Sciences

Community-acquired pneumonia (CAP) is a common condition in healthy people, causing morbidity and mortality worldwide despite latest advances in therapy and immunization procedures. Causative agents cannot be detected in approximately 50% of CAP episodes and therapy is initiated empirically. We aimed to determine the spectrum and frequency of the causative agents in patients with CAP in a university hospital. Materials and methods: Seventy seven adult patients hospitalized with CAP from November 2007 to March 2008 were included. CAP was diagnosed with clinical, radiological, and laboratory signs. Results: Sputum and blood cultures grew Streptococcus pneumoniae in 15 specimens; Haemophilus influenzae in …

The Efficacy, Safety, And Pharmacokinetics Of Intramuscular And Oral Phenyramidol In Patients With Low Back Pain In An Emergency Department, Hakan Ergün, Onur Polat, N. Arda Demi̇rkan, Müge Günalp, Serdar Gürler

Turkish Journal of Medical Sciences

To compare the efficacy, safety, and pharmacokinetics of oral and intramuscular (i.m.) phenyramidol in patients with low back pain. Materials and methods: Consecutive patients with low back pain were recruited and randomized (5:3) to treatment with either 800 mg oral or i.m. phenyramidol. Pain was assessed by visual analogue scale every 30 min for 2 h. Blood samples were drawn at baseline and every 15 min for 2 h. A 5-point verbal global evaluation scale was performed by both patients and physicians. In addition, the need for rescue analgesics after 2 h was noted. After the acute phase, patients were …

Comparison Of Serum Levels Of Il-6, Il-8, Tnf-Α, C Reactive Protein And Heat Shock Protein 70 In Patients With Active Or Inactive Behçet’S Disease, Remzi̇ Karadağ, Cemi̇le Koca, Yüksel Totan, Ramazan Yağci, Murat Aydin, Ayşe Serap Karadağ, Celi̇le Gülfer Akbay, Hati̇ce Meral Ekşi̇oğlu, Muhammet Ramazan Yi̇ği̇toğlu

Turkish Journal of Medical Sciences

The aim of this study was to elucidate serum levels of IL-6, IL-8, TNF-\alpha, CRP, and HSP 70 in patients with active or inactive Behçet's disease. Materials and methods: The study included 50 patients who met the International Study Group criteria for Behçet's disease. Of these, 26 had active disease and 24 had inactive disease. The control group was comprised of 25 age- and sex-matched healthy participants. Serum levels of IL-6, IL-8, TNF-\alpha, CRP, and HSP 70 were measured. Results: In patients with active disease, significantly higher mean serum levels of IL-6, IL-8, TNF-\alpha, and CRP were found compared to …

Plasma Vitamin A And E Levels In Patients With Gastroesophageal Cancer In Eastern Anatolia, Ömer Yilmaz, Hakan Dursun, Sai̇t Keleş, Ari̇f Yilmaz, Ni̇hat Okçu

Turkish Journal of Medical Sciences

Gastrointestinal system (GIS) cancers account for a significant percentage of morbidity and mortality worldwide. Free radicals may play a role in the development of GIS cancers at various stages. The goal of this study was to analyze the relationship between gastroesophageal cancer and plasma levels of vitamin A and vitamin E, a significant part of antioxidant defense. Materials and methods: Twenty-six patients with gastroesophageal cancer diagnosed by endoscopy and histopathologic examination and 26 healthy volunteer subjects were included in this study. Plasma vitamin A and vitamin E levels were determined by high-performance liquid chromatography using a commercially available kit. Results: …

The Effect Of Intradialytic Food Intake On The Urea Reduction Ratio And Single-Pool Kt/V Values In Patients Followed-Up At A Hemodialysis Center*, Belgüzar Kara, Cengi̇z Han Açikel

Turkish Journal of Medical Sciences

This study was conducted to determine the effect of intradialytic food intake on the urea reduction rate (URR) and single-pool Kt/V (spKt/V) values in hemodialysis (HD) patients. Materials and methods: The study was designed as a quasiexperiment. Twenty-five patients were enrolled in this study. The patients' mean age was 56.5 ± 13.0 years and median time on HD was 63 months. In the first stage of the study, patients were given a standard meal after the first hour of the treatment. The same study group underwent HD without intradialytic food intake 1 week later. Predialysis and postdialysis blood samples for …

Comparative Evaluation Of The Antifungal Susceptibility Of Candida Isolates From Blood Specimens: Results Of A Study In A Tertiary Care Hospital In Bursa, Turkey, Canan Evci̇, Beyza Ener, Güher Göral, Sevi̇m Akçağlar

Turkish Journal of Medical Sciences

Antifungal susceptibility testing may be an important aid in the treatment of patients with life threatening yeast infections. The aim of this study was to determine the susceptibility of Candida isolates obtained from clinical specimens to the antifungal agents amphotericin B and fluconazole, which are frequently used in our clinical practice. Materials and methods: Susceptibility to antifungal agents was investigated using the Etest (AB Biodisk, Solna, Sweden) and the reference broth macrodilution susceptibility test (CLSI M27-A2). The MICs obtained with each of the methods were read after 24 h and 48 h of incubation. Results: Overall agreement rates within ±1 …

Chlorella Viruses Encode Most, If Not All, Of The Machinery To Glycosylate Their Glycoproteins Independent Of The Endoplasmic Reticulum And Golgi, James L. Van Etten, James Gurnon, Giane M. Yanai-Balser, David Dunigan, Michael V. Graves

Nebraska Center for Virology: Faculty Publications

In contrast to all other viruses that use the host machinery located in the endoplasmic reticulum and Golgi to glycosylate their glycoproteins, the large dsDNA-containing chlorella viruses encode most, if not all, of the components to glycosylate their major capsid proteins. Furthermore, all experimental results indicate that glycosylation occurs independent of the endoplasmic reticulum and Golgi. (Review article)

Improving Quality Care Goals Through Diabetes Collaborative Rounds On An Exemplary Care And Learning Site, Stacey Smith Md, Facp, Marc Shalaby Md, Facp, Joyce Najarian Msn, Rn, Cde, Gretchen A. Perilli Md, Krista Casey Mba

Department of Medicine

No abstract provided.

Loss Of The Sin3 Transcriptional Corepressor Results In Aberrant Mitochondrial Function, Valerie L. Barnes, Bethany S. Strunk, Icksoo Lee, Maik Hüttemann, Lori A. Pile

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

SIN3 is a transcriptional repressor protein known to regulate many genes, including a number of those that encode mitochondrial components.

Results

By monitoring RNA levels, we find that loss of SIN3 inDrosophilacultured cells results in up-regulation of not only nuclear encoded mitochondrial genes, but also those encoded by the mitochondrial genome. The up-regulation of gene expression is accompanied by a perturbation in ATP levels in SIN3-deficient cells, suggesting that the changes in mitochondrial gene expression result in altered mitochondrial activity. In support of the hypothesis that SIN3 is necessary for normal mitochondrial function, yeastsin3null mutants exhibit very poor …

Definitions Of The Phenotypic Manifestations Of Sickle Cell Disease., Samir K Ballas, Susan Lieff, Lennette J Benjamin, Carlton D Dampier, Matthew M Heeney, Carolyn Hoppe, Cage S Johnson, Zora R Rogers, Kim Smith-Whitley, Winfred C Wang, Marilyn J Telen

Department of Medicine Faculty Papers

Sickle cell disease (SCD) is a pleiotropic genetic disorder of hemoglobin that has profound multiorgan effects. The low prevalence of SCD ( approximately 100,000/US) has limited progress in clinical, basic, and translational research. Lack of a large, readily accessible population for clinical studies has contributed to the absence of standard definitions and diagnostic criteria for the numerous complications of SCD and inadequate understanding of SCD pathophysiology. In 2005, the Comprehensive Sickle Cell Centers initiated a project to establish consensus definitions of the most frequently occurring complications. A group of clinicians and scientists with extensive expertise in research and treatment of …

Cellular And Molecular Dissection Of Pluripotent Adult Somatic Stem Cells In Planarians, Norito Shibata, Labib Rouhana, Kiyokazu Agata

Biological Sciences Faculty Publications

Freshwater planarians, Plathelminthes, have been an intriguing model animal of regeneration studies for more than 100 years. Their robust regenerative ability is one of asexual reproductive capacity, in which complete animals develop from tiny body fragments within a week. Pluripotent adult somatic stem cells, called neoblasts, assure this regenerative ability. Neoblasts give rise to not only all types of somatic cells, but also germline cells. During the last decade, several experimental techniques for the analysis of planarian neoblasts at the molecular level, such as in situ hybridization, RNAi and fluorescence activated cell sorting, have been established. Moreover, information about genes …

Visual Learning And Discrimination Of Abstract Visual Shapes By Crayfish, Matthew J. Boeve, Daniel A. Bergman

Student Summer Scholars Manuscripts

In nature, animals commonly experience multiple combinations of stimuli at various points in time. When two or more seemingly unrelated stimuli are detected at the same time using different sensory systems, there is the potential for an association to form between the stimuli. The animal may learn and show a response originally associated with one stimulus when it now detects the second stimulus. These stimuli are the unconditioned and conditioned stimulus of classical and operant conditioning. Many species of animals are known to learn via operant conditioning and a variety of responses can become associated with formerly neutral stimuli. Crayfish …

Patterned Cell Cultures For High Throughput Studies Of Cell Electrophysiology And Drug Screening Applications, Anupama Natarajan

Electronic Theses and Dissertations

Over the last decade, the field of tissue and bio-engineering has seen an increase in the development of in vitro high-throughput hybrid systems that can be used to understand cell function and behavior at the cellular and tissue levels. These tools would have a wide array of applications including for implants, drug discovery, and toxicology, as well as for studying cell developmental behavior and as disease models. Currently, there are a limited number of efficient, functional drug screening assays in the pharmacology industry and studies of cell-surface interactions are complicated and invasive. Most cell physiology studies are performed using conventional …

Studies On A Novel Human Cardiospecific Transcription Factor And Its Involvement In Omi/Htra2 Mediated Cell Death, Meenakshi Puthucode Balakrishnan

Electronic Theses and Dissertations

Omi/HtrA2 is a mitochondrial serine protease that is known to translocate to the cytoplasm upon induction of apoptosis and to activate caspase-dependent and caspase-independent cell death. The molecular mechanism of Omi/HtrA2's function is not clear but involves degradation of specific substrates. These substrates include cytoplasmic, mitochondrial, as well as nuclear proteins. We have isolated a new Omi/HtrA2 interactor, the THAP5 protein. THAP5 is a fifth member of a large family of transcription factors that are involved in cell proliferation, apoptosis, cell cycle control, chromosome segregation, chromatin modification and transcriptional regulation. THAP5 is an approximately 50kDa nuclear protein, with a restricted …

The Prognostic Value Of Histological Grade In The Outcome Of Patients With Invasive Breast Cancer, Gül Dağlar, Yunus Nadi̇ Yüksek, Ahmet Uğur Gözalan, Tanju Tütüncü, Yeşi̇m Güngör, Nuri̇ Aydin Kama

Turkish Journal of Medical Sciences

Prognostic factors are useful for the prediction of survival in breast cancer patients. According to many studies, tumor size and lymph node stage are the most powerful predictors of tumor behavior. The aim of the present study was to investigate the prognostic value of tumor histological grade. Materials and methods: The study included 214 operable breast cancer patients treated at the same institution that were evaluated to determine the prognostic value of tumor histological grade. Clinico-histopathological features of the patients were also evaluated for overall survival (OS) and disease-free survival (DFS). Results: Tumor histological grade was an independent factor in …

Can [F-18] Fluorodeoxyglucose Positron Emission Tomography Replace Sentinel Lymph Node Biopsy For The Detection Of Axillary Metastases In Patients With Early-Stage Breast Cancer?*, Semi̇h Görgülü, Mehmet Fati̇h Can, Oğuz Hançerli̇oğullari, Nuri̇ Arslan, Erkan Öztürk, Emel Öztürk, Müjdat Balkan, Turgut Tufan

Turkish Journal of Medical Sciences

To investigate the value of fluorodeoxyglucose positron emission tomography (FDG-PET) in detecting axillary involvement, and to compare its accuracy with sentinel lymph node biopsy (SLNB) in patients with clinically early-stage breast cancer. Materials and methods: Twenty-eight female patients with histologically-confirmed T1-2 breast cancer who were scheduled to have SLNB were included in the study. FDG-PET images were obtained 1-7 days prior to surgery with an intravenous injection of 370 MBq of FDG, while plasma glucose levels were maintained below 120 mg/dL. All the images were interpreted by 2 independent nuclear medicine specialists, who were blinded to the histological diagnoses. SLNB …

Do Uroflowmetric Findings Change By Treatment Of Urinary Tract Infection In Girls With Dysfunctional Voiding?, Emrah Şenel, Hüseyi̇n Tuğrul Ti̇ryaki̇, Fati̇h Akbiyik, Hali̇l Faruk Atayurt

Turkish Journal of Medical Sciences

The goal of the study was to evaluate the efficiency of repeated uroflowmetry study in girls who present with dysfunctional voiding with normal radiologic evaluation. Materials and methods: Twenty five children (25 girls with a mean age of 8.9 years) with recurrent urinary tract infection (UTI) and dysfunctional voiding who have normal radiologic evaluation were prospectively evaluated by uroflowmetry tests. Uroflowmetry study was repeated after the UTI treatment in asymptomatic period. Results: Mean urine volume was 254.31 ± 199.49 cc and the mean micturition time was 25.22 ± 15.43 s at the first uroflowmetry. Prolonged micturition time was noted in …

Comparison Of Remifentanil, Alfentanil, And Fentanil Co-Administered With Propofol To Facilitate Laryngeal Mask Insertion, Ali̇ Sizlan, Uğur Göktaş, Ceyda Özhan, Mehmet Özgür Özhan, Mehmet Emi̇n Orhan, Ercan Kurt

Turkish Journal of Medical Sciences

To compare the efficacy of different doses of fentanil, remifentanil, and alfentanil co-administered with propofol in patients undergoing minor surgery. Materials and methods: This double-blind, multi-centered, placebo-controlled study was conducted in 2 medical centers. One hundred forty-one ASA class I and II adult patients aged 18-65 years were included in the study. Patients received i.v. 1 µg kg^{-1} fentanil (group F, n = 33), 10 µg kg^{-1} alfentanil (group A, n = 33), 0.5 µg kg^{-1} remifentanil (group R, n = 36), or saline (control group, n = 39) co-administered with propofol 2.5 mg kg^{-1} without additives over 30 s. …

Single Shot “3-In-1” Femoral Nerve Blockade With 0.25% Or 0.375% Levobupivacaine Provides Similar Postoperative Analgesia For Total Knee Replacement, Alpaslan Apan, Fi̇li̇z Sari, Alp Burak Ekmekçi̇

Turkish Journal of Medical Sciences

To compare postoperative analgesia provided by single shot "3-in-1" femoral nerve blockade using 0.25% or 0.375% levobupivacaine in preceding with spinal anesthesia for unilateral total knee replacement surgery. Materials and methods: Forty consenting patients undergoing unilateral total knee arthroplasty were included in this prospective randomized study. Spinal anesthesia was achieved with 15 mg plain bupivacaine at the L3-4 or L4-5 interspace. After resolution of the spinal anesthesia, patients were randomized into 2 groups: "3-in-1" femoral nerve blocks were performed using 30 mL of 0.25% levobupivacaine (Group 1, n = 20) or 0.375% levobupivacaine (Group 2, n = 20). Pain was …

A Comparison Of The Treatment Of Ddh In The Older Children By Femoral Shortening With A) Acetabular Shelf And B) Innominate Osteotomy Plus Shelf, Meti̇n Doğan, Savaş Ağaoğlu, Durmuş Ali̇ Öçgüder, Mahmut Uğurlu, Rahmi̇ Yavuz Önem, Mustafa Aksoy, Murat Bozkurt

Turkish Journal of Medical Sciences

To examine the surgical outcome of 2 different techniques used in the treatment of developmental dislocation of the hip with delayed diagnosis. Materials and methods: The patients were divided into 2 groups based on the technique applied: 21 hips of 18 patients were included in Group 1 and 20 hips of 16 patients were included in Group 2. Initially, all the patients were subjected to femoral osteotomy, shortening, varization and derotation. In Group 1, additionally extra-articular grafting was performed for acetabulum and in Group 2, acetabular osteotomy and extraarticular grafting were performed. The mean age of Group 1 was 8 …

Suitable Empiric Antibiotic Therapy Saves Life In Nosocomial Pneumonia Caused By Stenotrophomonas Maltophilia, Gürdal Yilmaz, Savaş Özsu, İfti̇har Köksal, Tevfi̇k Özlü

Turkish Journal of Medical Sciences

Stenotrophomonas maltophilia is a nosocomial pathogen of increasing importance. Empiric antibiotic therapy for S. maltophilia infection is difficult because the microorganism is resistant to a number of agents typically used for health care associated infections, thus potentially increasing mortality. This study investigates 23 nosocomial pneumonia cases caused by S. maltophilia, the antibacterial sensitivity of the bacterium and the effect on mortality of suitable empiric therapy. Materials and methods: Twenty-three patients with nosocomial pneumonia caused by S. maltophilia between January 2000 and December 2006 at the Karadeniz Technical University Hospital were retrospectively investigated. Results: Suitable empiric therapy was used with 12 …

The Relationship Between Daily Caffeine Consumption And Withdrawal Symptoms: A Questionnaire-Based Study, Nermi̇n Küçer

Turkish Journal of Medical Sciences

To estimate daily caffeine intake among a group of university students at the Kocaeli Vocational School of Health Services in Turkey, and to determine the relationship between daily caffeine consumption and withdrawal symptoms. Materials and methods: This survey study was conducted using a questionnaire that was administered to 156 university students (129 females, 27 males) at the Kocaeli Vocational School of Health Services in Kocaeli, Turkey. The quantity of caffeine-containing products consumed was recorded on a daily basis, depending on the dietary habits of the consumer. The t test for differences between 2 proportions (using the normal approximation) was used …

Nitric Oxide And Trace Metals In Relation To Haemoglobin F Concentration In Nigerian Sickle Cell Disease Patients, John Ayodele Olaniyi, Olatubosun Ganiyu Arinola

Turkish Journal of Medical Sciences

Sickle cell disease (SCD) is an inherited haemoglobin (Hb) disorder associated with vaso-occlusive events, oxidative stress, high energy demand, and endothelial dysfunction. The endothelium plays a central role in the regulation of vascular homeostasis by releasing nitric oxide (NO) among other factors. Therefore, the objective of this study was to measure plasma levels of NO, trace metals, and HbF in SCD patients. Materials and methods: Plasma levels of NO, Zn, Mg, Mn, Se, Cu, Fe, Haemoglobin F (HbF) were measured in 59 steady state SCD patients referred to the Department of Haematology, University College Hospital, Ibadan, Nigeria and 35 age/sex …

Tetanus In An Intensive Care Unit Of A Turkish Hospital: Patient Analysis Of A 6-Year Period, Behi̇ce Kurtaran, Emre Karakoç, Aslihan Candevi̇r, Süheyla Kömür, Ayşe Seza İnal, Fi̇li̇z Ki̇bar, Yeşi̇m Taşova, Neşe Saltoğlu, Hasan Sali̇h Zeki̇ Aksu

Turkish Journal of Medical Sciences

To retrospectively evaluate the clinical features of patients admitted to the medical intensive care unit (ICU) of our hospital between January 2001 and May 2007 due to tetanus. Materials and methods: Patient vaccination history, incubation period, nosocomial infections, noninfectious conditions, mortality, and length of stay in the ICU and hospital were documented. Results: Fifteen tetanus patients were admitted during the 6-year period. Mean age of the patients (9 male, 6 female) was 60 ± 13 years. Median length of stay was 42 days (range: 30-77 days) for survivors and 7 days (range: 1-59 days) for non-survivors. Mortality was consequent to …