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Role Of Transient Receptor Potential Canonical Channels In Glioma Cell Biology, Valerie Christine Bomben Jan 2010

Role Of Transient Receptor Potential Canonical Channels In Glioma Cell Biology, Valerie Christine Bomben

All ETDs from UAB

ROLE OF TRANSIENT RECEPTOR POTENTIAL CANONICAL CHANNELS IN GLIOMA CELL BIOLOGY VALERIE C. BOMBEN DEPARTMENT OF NEUROBIOLOGY ABSTRACT Gliomas, primary brain tumors derived from glial cells, constitute the majority of malignant tumors within the central nervous system. The most malignant of these tumors, grade IV Glioblastoma multiforme, are characterized by extensive proliferation, cellular and nuclear atypia, angiogenesis, areas of necrosis, and widespread invasion into the brain parenchyma. Data from our lab and others have implicated ion channels in the invasion and proliferation of glioma cells. Moreover, calcium signaling in gliomas and other cells has been implicated in both migration and …

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Analyzing Dna Topology And Transcription In Salmonella Enterica Serovar Typhimurium During Dichotomous Growth, Betty M. Booker Jan 2010

Analyzing Dna Topology And Transcription In Salmonella Enterica Serovar Typhimurium During Dichotomous Growth, Betty M. Booker

All ETDs from UAB

The bacterial chromosome is dynamic. The principle goal of my research is to understand how DNA topology is altered by transcription in Salmonella enterica serovar Typhimurium LT2. Gamma delta-resolution requires two direct repeat Res sites to pair a plectonemic synapse. Previous work from our lab showed that the zones of high transcription inhibited gamma delta-resolution. Using phage λ recombineering methods, we have developed Salmonella strains to study ribosomal RNA operons, which are the most highly transcribed genes in bacteria. We propose a molecular model for how supercoiling generated by high levels of transcription modifies chromosome structure.

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Evolution Of Pneumococcal Serogroup 6, Preston Eugene Bratcher Jan 2010

Evolution Of Pneumococcal Serogroup 6, Preston Eugene Bratcher

All ETDs from UAB

Serogroup 6 of Streptococcus pneumoniae has been known to contain three serotypes, named 6A, 6B and 6C, with highly homologous capsule gene loci. The 6A and 6B capsule gene loci consistently differ from each other by only one nucleotide in the wciP gene. The 6A capsule gene locus has a galactosyltransferase (wciNα), which has been replaced with a glucosyltransferase (wciNß) in the 6C capsule gene locus. We considered that a new serotype, 6D, would be possible if the glucosyltransferase found in 6C strains was combined with the wciP gene from a 6B strain. We demonstrate that this gene combination yields …

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Development Of A Mucosal Vaccine Protective Against Francisella Tularensis Infection, Amit R. Ashtekar Jan 2010

Development Of A Mucosal Vaccine Protective Against Francisella Tularensis Infection, Amit R. Ashtekar

All ETDs from UAB

Francisella tularensis, a facultative intracellular, gram-negative coccobacillus, is the causative agent of tularemia and has been classified as a category A biological agent. Since there currently is no licensed vaccine available, in this study, we assessed the potential of a bivalent subunit vaccine comprising of DnaK and Tul4 to protect against respiratory tularemia. Intranasal immunization of C57BL/6 mice with DnaK, Tul4, and the adjuvant GPI-0100 resulted in mucosal and systemic antibody responses to DnaK and Tul4. In addition to antibody responses, this immunization regimen also induced both Th1 and Th2 cell-mediated immune responses specific for DnaK and Tul4. Finally, more …

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Regulation Of The Acid-Sensing Ion Channel 1 By Protein Kinase C And Matriptase, Edlira Bashari Jan 2010

Regulation Of The Acid-Sensing Ion Channel 1 By Protein Kinase C And Matriptase, Edlira Bashari

All ETDs from UAB

Acid-sensing ion channel 1 (ASIC1) is a member of the Epithelial Na+ channel/ Degenerin (ENaC/Deg) family of ion channels. Like the other members of this family, it is sensitive to the diuretic amiloride. It was previously shown that both normal astrocytes and glioma cells express ASIC1 and some ENaC subunits. However, only high-grade glioma cells exhibit an inward Na+ current that is sensitive to amiloride and to psalmotoxin 1 (PcTX-1), a specific blocker of ASIC1. Amiloride, PcTX-1, and the knockdown of ASIC1 reduce glioma cell migration. The exact composition of the amiloride-sensitive channel and the molecular mechanisms that regulate its …

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The Role Of Wnt5a In Mammary Gland Development, Sarah Baxley Jan 2010

The Role Of Wnt5a In Mammary Gland Development, Sarah Baxley

All ETDs from UAB

Transforming growth factor-beta (TGF-beta) negatively regulates mammary gland development and requires Wnt5a to exert some of these effects on mammary gland development. Wnt5a is a non-canonical signaling Wnt that is expressed in all stages of mammary gland development except lactation. Using slow release pellets containing Wnt5a, as well as Wnt5a null tissue, we previously showed that Wnt5a also acts to limit mammary development. Initial studies revealed a potential role for TGF-beta and Wnt5a in regulating mammary gland progenitor cells, indicating they may act to regulate the stem and progenitor cell population. In order to study the role of Wnt5a on …

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Canonical Wnt Signaling By The Proteolytic Processing Of Lrp6, Brandon Richard Beagle Jan 2010

Canonical Wnt Signaling By The Proteolytic Processing Of Lrp6, Brandon Richard Beagle

All ETDs from UAB

Low density Lipoprotein receptor Related 6 (LRP6) functions as an essential co-receptor for Wnt/Beat;-catenin signaling as pathway activation, reflected by cytosolic Beta-catenin stabilization and TCF/LEF-1 transactivation, requires Glycogen Synthase Kinase 3Beta(GSK3Beta)-mediated phosphorylation of multiple PPP(S/T)P motifs within the membrane anchored LRP6 intracellular domain. Additionally, LRP6 undergoes a proteolytic cleavage event resulting in the formation of a soluble LRP6 intracellular domain (LRP6-ICD). LRP6-ICD can function within the Wnt/Beta-catenin pathway by interacting with GSK3Beta and attenuating the phosphorylation of GSK3Beta substrates such as cytosolic Beta-catenin as well as stimulate TCF/LEF-1 activity. However, LRP6-ICD's role(s) within the Wnt/Beta-catenin pathway and the mechanism(s) that …

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A Nucleolar Specificity Factor For E2f1 Induced Cell Death, Jason Chang Paik Jan 2010

A Nucleolar Specificity Factor For E2f1 Induced Cell Death, Jason Chang Paik

All ETDs from UAB

The E2F family of transcription factors are important regulators of cell proliferation, and are often dysregulated in cancers. One member of the E2F family, E2F1, also has the ability to induce apoptosis; therefore, uncovering how E2F1-induced apoptosis is controlled is of interest in understanding tumorigenesis. To this end, we identified RRP1B as a novel target specifically induced by E2F1. RRP1B expression is specifically upregulated by E2F1 overexpression, but not other E2F family members. RRP1B expression is correlated with E2F1 expression during the cell cycle, and is significantly induced after DNA damage. The minimal RRP1B promoter region responsive to E2F1 was …

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Pneumococcal Vaccine Response And Aging In Human, Saeyoung Park Jan 2010

Pneumococcal Vaccine Response And Aging In Human, Saeyoung Park

All ETDs from UAB

Streptococcus pneumoniae is a major human pathogen, especially for young children and older adults. To protect from pneumococcal diseases, 23-valent pneumococcal polysaccharide vaccine (PPV23) has been used clinically since 1983. However, PPV23 is not so effective among old adults with its protective efficacy diminishing with age. We confirmed that young and old adults, who were immunized with PPV23, have comparable pneumococcal polysaccharide (PS) specific IgG levels. Interestingly, we found that old adults had lower IgA and IgM antibody levels than young adults for three serotypes (serotype 14, 18C and 23F). Consistent with the previous results, opsonic capacities of immune sera …

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Regulation Of Vascular Smooth Muscle Cell Signaling And Metabolism By Platelet-Derived Growth Factor, Jessica Perez Jan 2010

Regulation Of Vascular Smooth Muscle Cell Signaling And Metabolism By Platelet-Derived Growth Factor, Jessica Perez

All ETDs from UAB

Growth factors are important inducers of vascular cell growth whose regulation is altered during the pathogenesis of atherosclerosis. An increase in growth factor and cytokine production, as well as lipid oxidation is observed in cardiovascular disease (CVD) and contributes to altered vascular cell signaling, exacerbated atherosclerotic lesions and heart failure. A change in cellular bioenergetic status due to mitochondrial dysfunction or damage has also been noted in CVD. In this thesis, we first examine cell signaling pathways in vascular smooth muscle cells (VSMC) which are activated in response to platelet-derived growth factor (PDGF) and regulate the cell cycle protein changes …

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Dna Replication And Cytokinesis In Drosophila Melanogaster, Anton Svitin Jan 2010

Dna Replication And Cytokinesis In Drosophila Melanogaster, Anton Svitin

All ETDs from UAB

DNA replication and cytokinesis are two important parts of the cell division process. Our studies address different aspects of both of these processes and potential links between them. One of the best approaches for studying DNA replication in eukaryotes has been an analysis in cell free in vitro systems. The existing cell free replication systems for Drosophila are relatively ineffective. In the first part of this work, we have developed an optimized in vitro system to study DNA replication using early egg extracts of Drosophila. Our studies indicate that this system proves to be an extremely useful tool for a …

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The Structural And Functional Studies Of Yeast Nucleotide Exchange Factor Sil1p And Its Complex With Bip, Ming Yan Jan 2010

The Structural And Functional Studies Of Yeast Nucleotide Exchange Factor Sil1p And Its Complex With Bip, Ming Yan

All ETDs from UAB

Sil1 is an Endoplasmic Reticulum (ER) localized protein. SIL1 was initially identified as a UPR-regulated gene. Later studies show Sil1 functions as the nucleotide exchange factor of ER lumenal Hsp70--Bip by directly interacting with the ATPase domain of Bip. Currently, the molecular mechanism how Sil1 catalyzes nucleotide exchange of Bip is still elusive. In this study we determine the complex structure of yeast S.cerevisia Sil1 and Bip (also called Kar2) ATPase domain at 2.3Å resolution by Single-anomalous dispersion (SAD) methods. The Sil1-Bip complex structure reveals that one sil1 molecule interacts with one Bip ATPase domain molecule to form the complex. …

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A Timp2-Armed Conditionally-Replicating Adenovirus For The Treatment Of Ovarian Cancer, Sherry Wei Yang Jan 2010

A Timp2-Armed Conditionally-Replicating Adenovirus For The Treatment Of Ovarian Cancer, Sherry Wei Yang

All ETDs from UAB

Ovarian cancer remains the most lethal gynecological malignancy in the U.S. Conventional therapies have limited therapeutic value due to advanced stage of the disease at diagnosis. Conditionally-replicating adenoviruses (CRAds) are promising, novel anti-cancer agents that are designed to selectively replicate in and lyse tumor cells. In clinical trials, CRAds exhibited limited efficacy thus far. Second generation CRAds are being developed to express a therapeutic protein to further enhance antitumor efficacy. One attractive target in ovarian tumor microenvironment is the matrix metalloproteinases (MMPs) that degrade the extracellular matrix. Thus, tissue inhibitor of metalloproteinase 2 (TIMP2), an endogenous inhibitor of MMPs, is …

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Cross-Talk Between Marginal Zone B Cells And Marginal Zone Macrophages, Yuying You Jan 2010

Cross-Talk Between Marginal Zone B Cells And Marginal Zone Macrophages, Yuying You

All ETDs from UAB

the test of group differences and the test of covariate. When we force the predictors in the

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Roles Of Nr4a3 In Insulin Sensitivity In Skeletal Muscle, Xiaolin Zhu Jan 2010

Roles Of Nr4a3 In Insulin Sensitivity In Skeletal Muscle, Xiaolin Zhu

All ETDs from UAB

For the past several decades, the prevalence of Type 2 Diabetes and the metabolic syndrome has been increasing. Insulin resistance is the central pathogenic event for these diseases. We previously reported that the NR4A family of orphan nuclear receptors augments insulin sensitivity in adipocytes. We now found that lentiviral mediated NR4A3 hyper-expression increased insulin stimulated glucose transport (ISGT) in C2C12 myocytes while NR4A3 knock-down exhibited opposite effect. We also examined the effects of prostaglandin A2 (PGA2) on insulin action and NR4A3 trans-activation in C2C12 myocytes. PGA2 augmented ISGT and insulin stimulated AKT phosphorylation in C2C12 myocytes. Importantly, PGA2 treatment led …

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Evolution And Genetic Diversity In Streptococcus Pneumoniae, Diana Lee Dupraw Jan 2010

Evolution And Genetic Diversity In Streptococcus Pneumoniae, Diana Lee Dupraw

All ETDs from UAB

The relative contributions of point mutations and intergenomic recombination via lateral gene transfer (LGT) determine the population structure and evolutionary style for a given bacterial species. Streptococcus pneumoniae has a weakly clonal population structure; adaptive clonal complexes can be detected; however, these can also be rapidly lost due to the high rate of recombination. To characterize the diversity of pneumococcal isolates in clonal complex, and to elucidate possible mechanisms for the long-term stability of such complexes, 35 serotype 6B strains belonging to a previously identified clonal complex, CC14, were assayed by Comparative Genome Hybridization (CGH) and Multi Locus Sequence Typing …

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In Remembrance Of Denis Alan Trevor New, Robert L. Brent Dr. Jan 2010

In Remembrance Of Denis Alan Trevor New, Robert L. Brent Dr.

The Selected Works of Robert Brent

None

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Ionizing Radiation, Robert L. Brent Dr. Jan 2010

Ionizing Radiation, Robert L. Brent Dr.

The Selected Works of Robert Brent

None

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Expression Of The Intestinal Biomarkers Guanylyl Cyclase C And Cdx2 In Poorly Differentiated Colorectal Carcinomas., Brody Winn, Rosemarie Tavares, Andres Matoso, Lelia Noble, Jacqueline Fanion, Scott A Waldman, Murray B Resnick Jan 2010

Expression Of The Intestinal Biomarkers Guanylyl Cyclase C And Cdx2 In Poorly Differentiated Colorectal Carcinomas., Brody Winn, Rosemarie Tavares, Andres Matoso, Lelia Noble, Jacqueline Fanion, Scott A Waldman, Murray B Resnick

Department of Pharmacology and Experimental Therapeutics Faculty Papers

Guanylyl cyclase C, a receptor for bacterial diarrheagenic enterotoxins, is expressed selectively by intestinal epithelium and is an endogenous downstream target of CDX2. The expression of Guanylyl cyclase C is preserved throughout the adenoma/carcinoma sequence in the colorectum. Detection of Guanylyl cyclase C expression by reverse transcriptase-polymerase chain reaction is currently being validated as a technique to identify occult lymph node metastases in patients with colorectal cancer and for circulating cells in the blood for postoperative surveillance. Although Guanylyl cyclase C is widely expressed by well-differentiated colorectal cancer, its expression in poorly differentiated colorectal cancer has not been evaluated. A …

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Safety Assessment For Tipranavir : A Protease Inhibitor Treatment For Hiv Infected Adults, Jaromir Mikl Jan 2010

Safety Assessment For Tipranavir : A Protease Inhibitor Treatment For Hiv Infected Adults, Jaromir Mikl

Legacy Theses & Dissertations (2009 - 2024)

Dose-limiting adverse events associated with anti-retroviral therapy (ART) generally include gastro-intestinal (GI) issues such as vomiting and nausea. However, serious adverse events (SAEs) do occur, the most frequent of which include liver toxicities and renal impairment as well as recent evidence of cardio-vascular disease (CVD) risk.

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Effects Of Adenosine A1 Receptor Agonist Ccpa And Antagonist Dpcpx On Ischemia/Reperfusion-Induced Arrhythmias In Rats*, Ömer Bozdoğan, Ersöz Gonca, Nuran Ekerbi̇çer Jan 2010

Effects Of Adenosine A1 Receptor Agonist Ccpa And Antagonist Dpcpx On Ischemia/Reperfusion-Induced Arrhythmias In Rats*, Ömer Bozdoğan, Ersöz Gonca, Nuran Ekerbi̇çer

Turkish Journal of Medical Sciences

Adenosine has been commonly used to treat supraventricular tachycardia in clinics. However, there are only a few studies on the effects of adenosine on ischemia or reperfusion induced arrhythmia and they conflict with the results of the present study. During this study, we aimed to clarify the effect of adenosine on ischemia-reperfusion induced arrhythmia. Materials and methods: Left coronary artery was ligated for 6 min and it was released for 15 min to produce reperfusion. A1 adenosine agonist CCPA (2 Chloro - N6 - Cyclopentyl-adenosine), and A1 selective antagonist DPCPX (8 - Cyclopentyl - 1,3 -dipropylxanthine) in 5 µg/kg dose …

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Morphine Modulates Microvascular Leakage Dose-Dependently In The Airway Of Ovalbumin-Sensitized Rats, Seyfullah Oktay Arslan Jan 2010

Morphine Modulates Microvascular Leakage Dose-Dependently In The Airway Of Ovalbumin-Sensitized Rats, Seyfullah Oktay Arslan

Turkish Journal of Medical Sciences

To investigate the effect of morphine on ovalbumin-evoked airway microvascular leakage in sensitized rats. Materials and methods: Rats were sensitized on days 0, 14, and 21 with ovalbumin. Intravenous ovalbumin (2 mg/kg) or capsaicin (50 µg/kg) increased the extravasation of Evans blue dye in trachea, bronchi, and intra-pulmonary tissues of sensitized rats. Results: Morphine (1-10 mg/kg) inhibited ovalbumin-evoked increase in microvascular plasma leakage in a dose-dependent manner; however, it had no significant effect at the doses of 0.1 or 30 mg/kg. In addition, morphine, at the doses of 1-30 mg/kg, abolished microvascular leakage increased by capsaicin. The inhibition caused by …

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The Effect Of L-Tryptophan On The Heart In Rabbits Via Chronic Hypoxia, Fi̇gen Nari̇n, Nazmi̇ Nari̇n, Fatmagül Başarslan, Ali̇ Baykan, Sadetti̇n Sezer, Hülya Akgün, Aynur Akin, Mustafa Akçakuş, Hakan Ceyran Jan 2010

The Effect Of L-Tryptophan On The Heart In Rabbits Via Chronic Hypoxia, Fi̇gen Nari̇n, Nazmi̇ Nari̇n, Fatmagül Başarslan, Ali̇ Baykan, Sadetti̇n Sezer, Hülya Akgün, Aynur Akin, Mustafa Akçakuş, Hakan Ceyran

Turkish Journal of Medical Sciences

To evaluate the protective effect of tryptophan on an experimentally produced hypoxic myocardial injury via biochemical and pathological parameters. Materials and methods: A total of 26 rabbits were divided into 3 groups. Group 1 (n = 9) was only exposed to hypoxia. Group 2 (n = 10) was exposed to hypoxia and received L-tryptophan (200 mg/kg per day, orally for 5 days). Group 3 (n = 7) was the control group. Before the hypoxic injury and after the delivery of the medication, serum samples were taken for troponin-I, creatine kinase myocardial isoenzymes (CK-MB), lactate dehydrogenase (LDH), glutathione peroxidase (GSH-Px), superoxide …

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Marital Adjustment And Emotional Symptoms In Infertile Couples: Gender Differences, Verda Tüzer, Altuğ Tuncel, Sema Göka, Süheyla Doğan Bulut, Fati̇h Volkan Yüksel, Ali̇ Atan, Erol Göka Jan 2010

Marital Adjustment And Emotional Symptoms In Infertile Couples: Gender Differences, Verda Tüzer, Altuğ Tuncel, Sema Göka, Süheyla Doğan Bulut, Fati̇h Volkan Yüksel, Ali̇ Atan, Erol Göka

Turkish Journal of Medical Sciences

To determine the psychosocial and demographic factors related to marital adjustment and emotional symptoms in infertile couples according to gender differences. Materials and methods: The study sample, consisting of 60 primary infertile couples, was assessed using the Beck Depression Inventory, State and Trait Anxiety Inventory, and Dyadic Adjustment Scale. The scores derived from men and women were compared according to infertility factor. Multiple regression analysis models were used to explore the linkages between emotional symptoms and marital adjustment. Results: Statistically significant gender differences were noted in affectional expression and sexual satisfaction domains of the Dyadic Adjustment Scale (P < 0.05). Our analyses showed that various aspects of marital adjustment have predictive power on anxiety and depressive symptoms of infertile men, especially when the infertility is due to male factor. Conclusion: Results of this study emphasize the importance of psychological and sexual counseling in the course of infertility treatment.

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Implications Of Socio-Economic Status On The Dietary Fatty Acid Intakes In Turkish Women, Zehra Büyüktuncer, Berat Nursal Tosun, Ayli̇n Ayaz, Makbule Gezmen Karadağ, Alev Kocabaş Keser, Meral Aksoy, Mi̇ne Yurttagül, Sevi̇nç Yücecan, Hali̇t Tanju Besler Jan 2010

Implications Of Socio-Economic Status On The Dietary Fatty Acid Intakes In Turkish Women, Zehra Büyüktuncer, Berat Nursal Tosun, Ayli̇n Ayaz, Makbule Gezmen Karadağ, Alev Kocabaş Keser, Meral Aksoy, Mi̇ne Yurttagül, Sevi̇nç Yücecan, Hali̇t Tanju Besler

Turkish Journal of Medical Sciences

To investigate the effects of socio-economic status (SES) on the dietary intakes of fatty acids in a group of Turkish women. Materials and methods: Five hundred and sixty three women were randomly enrolled into the study. They were classified into 3 SES groups: group 1 high (n = 186), group 2 medium (n = 186), and group 3 low (n = 191). The groups were determined by the SES distribution of Ankara as determined by the 2000 census. Each participant was investigated with a questionnaire consisting of demographic characteristics, physical activity level (24-h record), and dietary intake (24-h recall) by …

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Exposure To Continuous Darkness Leads To Atypical Symptoms Of Seasonal Affective Disorder In Rats, Çağla Ayhan İşman, Nesli̇han Toyran, Ni̇met Ünay Gündoğan Jan 2010

Exposure To Continuous Darkness Leads To Atypical Symptoms Of Seasonal Affective Disorder In Rats, Çağla Ayhan İşman, Nesli̇han Toyran, Ni̇met Ünay Gündoğan

Turkish Journal of Medical Sciences

Prolonged duration of nocturnal melatonin increase has been implicated in the pathogenesis of the seasonal affective disorder (SAD) winter depression. This study was designed to investigate behavioral and physiological consequences of constant dark exposure in male rats for its potential application to human affective disorders. Materials and methods: A total of 12 male Wistar-Albino rats (230-290 g) were assigned to control (LD 12:12 h; n = 6) and constant darkness (DD, 10 days; n = 6) groups. Experimental protocol included comparison of behavioral (FST, open field test, and sucrose preference) and physiological (body weight, food intake, and blood glucose level) …

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Anti-Diabetic Activity Of Tinospora Cordifolia (Willd.) In Streptozotocin Diabetic Rats; Does It Act Like Sulfonylureas?, Nagaraja Puranik, Kararashah Fakruddin Kammar, Sheela Devi Jan 2010

Anti-Diabetic Activity Of Tinospora Cordifolia (Willd.) In Streptozotocin Diabetic Rats; Does It Act Like Sulfonylureas?, Nagaraja Puranik, Kararashah Fakruddin Kammar, Sheela Devi

Turkish Journal of Medical Sciences

As an alternative medicine to treat diabetes mellitus, many herbal drugs are being studied throughout the world. In the present study, an attempt was made to investigate the anti-diabetic activity of Tinospora cordifolia (Willd.) (TC) stem extracts (both aqueous and alcoholic) in different dosages (200 and 400 mg/kg b.w.) in streptozotocin diabetic albino rats. The probable mechanism by which TC may act as an anti-hyperglycemic drug was also investigated. Materials and methods: The drug was administered orally for 10 days and 30 days in different groups of animal, with each group containing 6 animals. The efficacy of this drug was …

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Isolation Of Cryptococcus Neoformans From Pigeon Droppings In Ahwaz, Iran, Majid Zarrin, Masoomeh Jorfi, Nasrin Amirrajab, Morad Rostami Jan 2010

Isolation Of Cryptococcus Neoformans From Pigeon Droppings In Ahwaz, Iran, Majid Zarrin, Masoomeh Jorfi, Nasrin Amirrajab, Morad Rostami

Turkish Journal of Medical Sciences

Cryptococcus neoformans is an opportunistic human pathogen that causes cryptococcosis, a life-threatening infection that is usually manifested as menigeoencephalitis mainly in immunocompromised patients. The objective of this study was to evaluate the presence of Cryptococcus neoformans in Ahwaz, Iran. Materials and methods: Sixty-five samples of pigeon droppings were collected from 10 different regions in Ahwaz. Each sample was suspended 1:10 in saline solution and then cultured in Sabouraud's dextrose agar medium including chloramphenicol. Identification of C. neoformans was performed on the basis of melanin synthesis on bird seed agar, presence of a capsule on India ink preparation, urease production on …

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Association Between Prepregnancy Body Mass Index, Gestational Weight Gain, And Perinatal Outcomes, İlknur İnegöl Gümüş, Feri̇dun Karakurt, Ayşe Kargili, Ni̇lgün Öztürk Turhan, Mehtap Erkmen Uyar Jan 2010

Association Between Prepregnancy Body Mass Index, Gestational Weight Gain, And Perinatal Outcomes, İlknur İnegöl Gümüş, Feri̇dun Karakurt, Ayşe Kargili, Ni̇lgün Öztürk Turhan, Mehtap Erkmen Uyar

Turkish Journal of Medical Sciences

We aimed to investigate the effects of prepregnancy body mass index (BMI) and excess gestational weight gain on maternal-fetal outcomes. Materials and methods: Obstetrics records of 537 singleton pregnants delivered at our institution were reviewed. According to BMI, the patients were divided into 3 groups, namely, Group 1: normal (BMI 20-24.9 kg/m^2) (n = 394); Group 2: overweight (BMI 25-29.9 kg/m^2) (n = 112); Group 3: Obese (BMI > 30 kg/m^2) (n = 31). According to gestational weight gain, the subjects divided into 2 categories, namely, Group A: 8-15.9 kg weight gain (n = 326); Group B: >16kg weight gain (n …

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Trace Elements And Physical Activity In Children And Adolescents With Depression, M. Meti̇n Donma, Orki̇de Donma Jan 2010

Trace Elements And Physical Activity In Children And Adolescents With Depression, M. Meti̇n Donma, Orki̇de Donma

Turkish Journal of Medical Sciences

Depression is a common mental health problem among adolescents. Depressive symptoms are also important and may appear even during the preschool period. Physical activity, which may improve some mental health problems, is inversely associated with depression. Due to the presence of some clinical evidence about the relation between the use of antidepressants and suicide, there is a need for supportive agents during antidepressant therapy. Within this context, essential trace elements gain importance for further consideration. Protection of the developing brain from the negative effects of iron deficiency is important because of iron deficiency's association with poor mental development. Reactions between …

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