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Purpose And Criteria For Blood Smear Scan, Blood Smear Examination, And Blood Smear Review., Gene Gulati, Jinming Song, Alina Dulau Florea, Jerald Gong

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

A microscopic examination of an appropriately prepared and well-stained blood smear by a knowledgeable laboratory professional is necessary and clinically useful in a number of circumstances and for a variety of reasons. In this article, an attempt is made to delineate the purpose and criteria for blood smear examination in a variety of circumstances that are encountered in everyday laboratory hematology practice. A blood smear scan serves to at least (a) verify the flagged automated hematology results and (b) determine if a manual differential leukocyte count needs to be performed. Blood smear examination/manual differential leukocyte count with complete blood count …

Ethanol Diverts Early Neuronal Differentiation Trajectory Of Embryonic Stem Cells By Disrupting The Balance Of Lineage Specifiers., Rosa Sánchez-Alvarez, Saurabh Gayen, Rajanikanth Vadigepalli, Helen Anni

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

BACKGROUND: Ethanol is a toxin responsible for the neurodevelopmental deficits of Fetal Alcohol Spectrum Disorders (FASD). Recent evidence suggests that ethanol modulates the protein expression of lineage specifier transcription factors Oct4 (Pou5f1) and Sox2 in early stages of mouse embryonic stem (ES) cell differentiation. We hypothesized that ethanol induced an imbalance in the expression of Oct4 and Sox2 in early differentiation, that dysregulated the expression of associated and target genes and signaling molecules and diverted cells from neuroectodermal (NE) formation.

METHODOLOGY/PRINCIPAL FINDINGS: We showed modulation by ethanol of 33 genes during ES cell differentiation, using high throughput microfluidic dynamic array …

The Contributions Of Hif-Target Genes To Tumor Growth In Rcc., Ting Zhang, Xiaohua Niu, Lili Liao, Eun-Ah Cho, Haifeng Yang

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Somatic mutations or loss of expression of tumor suppressor VHL happen in the vast majority of clear cell Renal Cell Carcinoma, and it's causal for kidney cancer development. Without VHL, constitutively active transcription factor HIF is strongly oncogenic and is essential for tumor growth. However, the contribution of individual HIF-responsive genes to tumor growth is not well understood. In this study we examined the contribution of important HIF-responsive genes such as VEGF, CCND1, ANGPTL4, EGLN3, ENO2, GLUT1 and IGFBP3 to tumor growth in a xenograft model using immune-compromised nude mice. We found that the suppression of VEGF or CCND1 impaired …

Rhob Controls Coordination Of Adult Angiogenesis And Lymphangiogenesis Following Injury By Regulating Vezf1-Mediated Transcription., Damien Gerald, Irit Adini, Sharon Shechter, Carole Perruzzi, Joseph Varnau, Benjamin Hopkins, Shiva Kazerounian, Peter Kurschat, Stephanie Blachon, Santosh Khedkar, Mandrita Bagchi, David Sherris, George C Prendergast, Michael Klagsbrun, Heidi Stuhlmann, Alan C Rigby, Janice A Nagy, Laura E Benjamin

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Mechanisms governing the distinct temporal dynamics that characterize post-natal angiogenesis and lymphangiogenesis elicited by cutaneous wounds and inflammation remain unclear. RhoB, a stress-induced small GTPase, modulates cellular responses to growth factors, genotoxic stress and neoplastic transformation. Here we show, using RhoB null mice, that loss of RhoB decreases pathological angiogenesis in the ischaemic retina and reduces angiogenesis in response to cutaneous wounding, but enhances lymphangiogenesis following both dermal wounding and inflammatory challenge. We link these unique and opposing roles of RhoB in blood versus lymphatic vasculatures to the RhoB-mediated differential regulation of sprouting and proliferation in primary human blood versus …

Faculty Publications 2012, Lsu Health Sciences Center New Orleans

Historical Faculty Publications

This Faculty bibliography contains 821 publications.

Design, Manufacturing, And Assembly Of A Flexible Thermoelectric Device, Christopher Anthony Martinez

USF Tampa Graduate Theses and Dissertations

This thesis documents the design, manufacturing, and assembly of a flexible thermoelectric device. Such a device has immediate use in haptics, medical, and athletic applications. The governing theory behind the device is explained and a one dimensional heat transfer model is developed to estimate performance. This model and consideration for the manufacturing and assembly possibilities are the drivers behind the decisions made in design choices. Once the design was finalized, manufacturing methods for the various components were explored. The system was created by etching copper patterns on a copper/polyimide laminate and screen printing solder paste onto the circuits. Thermoelectric elements …

The Role Of Molecular Chaperones In The Etiology And Treatment Of Psychiatric Diseases In The Elderly, John Clarence O'Leary

USF Tampa Graduate Theses and Dissertations

The elderly are at increased risk for developing psychiatric diseases, which include Alzheimer's disease, depression, anxiety and suicide. The probability of multiple disease comorbidity is also increased in the elderly. At the cellular level, the loss of protein homeostasis is often at the root of disease emergence, and thus the scientific community is searching for ways to help maintain this balance. A vast group of proteins that are paramount to balancing and counterbalancing protein levels is the molecular chaperone protein group, which has evolved a tremendous variety of functions in the cell. They aid in protein trafficking, folding, receptor signaling, …

The Inflammatory Response Initiated By The Spleen To Ischemic Stroke, Hilary Seifert

USF Tampa Graduate Theses and Dissertations

The peripheral immune system plays a role in delayed neural injury after stroke. This response originates from the spleen as splenectomy prior to middle cerebral artery occlusion (MCAO) in rats significantly reduces infarct volume in the brain. This research is based on the hypothesis that inhibiting the splenic response will reduce neurodegeneration after stroke. Studies in animals have implicated lymphocytes as the immune cell type that is detrimental following MCAO. Interferon gamma (IFNγ) has been identified as a pro-inflammatory cytokine that is also detrimental following stroke. IFNγ is important because it activates microglia and macrophages in a pro-inflammatory nature that …

Molecular And Cellular Mechanisms Of Reelin Signaling In The Adult Hippocampus, Justin Howard Trotter

USF Tampa Graduate Theses and Dissertations

The Reelin signaling pathway is critical for neuronal migration during development and the function of excitatory synapses in the adult forebrain. Despite a growing body of evidence implicating impaired Reelin signaling in the pathogenesis of numerous neuropsychiatric and neurodegenerative disorders, including Schizophrenia and Alzheimer's disease, little is known still regarding the specific molecular and cellular mechanisms whereby Reelin signaling modulates the function of synapses to enable normal learning and memory. In this dissertation, we addressed these knowledge gaps by identifying mechanisms of Reelin proteolysis following synaptic potentiation (Chapter 2) and dissociated the synaptic function of Reelin signaling at excitatory (Chapter …

Diet-Induced Ketosis And Calorie Restriction In Mouse Models Of Alzheimer's Pathology, Milene Lara Brownlow

USF Tampa Graduate Theses and Dissertations

Dietary manipulations and their pharmacological outcomes have been increasingly studied in neurodegenerative diseases. However, a systematic comparison among different methods in validated animal models of Alzheimer's disease is made necessary due to several different approaches applied in recent studies. Moreover, despite the large body of evidence on the effects of calorie restriction (CR) and ketogenic diets (KDs) on amyloid pathology, no consistent data is available on the effects of calorie restriction, ketogenic diet or ketone supplements on tau pathology in transgenic models of AD. Moreover, the ketogenic diet used in our studies was custom made with low carbohydrate content and …

The Correlation Between Metabolic Syndrome And Lower Urinary Tract Symptoms In Females, Cevdet Serkan Gökkaya, Cüneyt Özden, Bi̇nhan Kağan Aktaş, Hüseyi̇n Ci̇han Demi̇rel, Özer Güzel, Mehmet Karabakan, Aki̇f Ersoy Erkmen, Çeti̇n Volkan Özteki̇n, Ali̇ Memi̇ş

Turkish Journal of Medical Sciences

To evaluate the association between lower urinary tract symptoms (LUTS) and metabolic syndrome (MS) in women. Materials and methods: A total of 155 women with LUTS were included in the study. LUTS were evaluated using the International Prostate Symptom Score (IPSS) and the Bristol Female Lower Urinary Tract Symptoms (BFLUTS) questionnaire. Besides total IPSS, voiding and storage IPSS were calculated separately. Diagnosis of MS was made according to the consensus report of the International Diabetes Foundation. The patients were classified into 3 groups: those without MS (group 1), those with 3 risk factors of MS (group 2), and those with …

Does Adma Affect The Oxidant/Antioxidant Balance In Rats?, Hasan Alaçam, Bahatti̇n Avci, Osman Şaliş, Ahmet Di̇lek, Ahmet Kozan, Cuma Mertoğlu, Mehmet Şahi̇n, Ali̇ Okuyucu

Turkish Journal of Medical Sciences

Asymmetric dimethylarginine (ADMA) is an inhibitor of nitric oxide synthase (NOS). Oxidative stress might be defined as an imbalance between protein oxidation and antioxidants. Our aim was to determine in vivo whether ADMA causes oxidative damage. Materials and methods: Thirty rats were divided into 3 equal groups: a control group, a group administered 1 mg/kg ADMA, and a group administered 2 mg/kg ADMA. ADMA was administered intraperitoneally for 7 days. Malondialdehyde (MDA), protein carbonyl (PC) content, and nitrate+nitrite concentrations were measured with serum samples. Superoxide dismutase (SOD), catalase, and glutathione peroxidase (GSH-Px) activities were analyzed with plasma samples. Results: A …

Serum Interleukin-8, Ca-125 Levels, Neutrophil-To-Lymphocyte Ratios, And Combined Markers In The Diagnosis Of Endometriosis, Cemi̇le Dayangan Sayan, Müzeyyen Gülnur Özakşi̇t, Esma Sarikaya, Özlem Gün Eryilmaz, Leyla Mollamahmutoğlu, Rüya Deveer

Turkish Journal of Medical Sciences

Our aim was to investigate the usefulness of serum interleukin-8 (IL-8) and the neutrophil-to-lymphocyte ratio (NLR), either by themselves or as adjuncts to CA-125, in the diagnosis of various stages of endometriosis. Materials and methods: This study was a single-centre, prospective, group-comparative clinical trial. Serum IL-8 and the NLR, either alone or as adjuncts to CA-125, were analysed using receiver-operating characteristic (ROC) analysis to diagnose endometriosis. Fifty patients with endometriosis and 50 patients with benign ovarian cysts were included in this study. Results: The overall sensitivity and specificity of the combined markers for the detection of endometriosis were 80.0% and …

Measurement Of The In-Air Output Ratio For High-Energy Photon Beams Used In Radiotherapy, Murugan Appasamy, Sidonia Valas Xavier, Thayalan Kuppusamy, Ramasubrmanian Velayudham

Turkish Journal of Medical Sciences

To measure the in-air output ratio of a 15-MV photon beam using locally designed miniphantoms. Materials and methods: Columnar and brass miniphantoms were designed locally to accommodate 0.6 cc and 0.13 cc ionization chambers. The in-air output ratio (S_C) was measured for square, rectangular, and wedged fields for 15 MV. The influences of the orientation of the miniphantom, miniphantom material, and chamber volume on S_C and the collimator exchange effect were also studied. Results: The S_C measurements ranged from 0.944 to 1.0321 for the studied field sizes. The orientation of the miniphantom had no influence on S_C for the range …

What Would Happen If Neurovascular Bundles Were Left Behind In Radical Retropubic Prostatectomy?, Zi̇ya Akbulut, Olçay Kandemi̇r, Ali̇ Fuat Atmaca, Durmuş Alparslan Demi̇rci̇, Bayram Doğan, Abdullah Erdem Canda, Mevlana Derya Balbay

Turkish Journal of Medical Sciences

To evaluate whether nerve-sparing radical prostatectomy (NSRP) results in a residual tumor in the remaining neurovascular bundle (NVB). Materials and methods: A total of 88 patients underwent bilateral NSRP. The ipsilateral NVB was excised uni-/bilaterally on the tumor side, separately. Factors affecting NVB involvement were evaluated. Results: The mean patient age and preoperative serum prostate specific antigen (PSA) were 63.8 ± 6.2 years (49-76) and 12.9 ± 9.4 ng/mL (2.4-45.5), respectively. Digital rectal examination (DRE) suggested nodules in 34 patients (38.6%). Uni- and bilateral NVB resections were performed on 40 (45.5%) and 48 patients (54.5%), respectively, according to transrectal ultrasound-guided …

Do Characteristics Of Seriously Injured Older Adults Differ From Those Of Their Younger Counterparts In The Emergency Department?, Ayhan Aköz, Memet Işik, Hüseyi̇n Şahi̇n, Mücahi̇t Emet

Turkish Journal of Medical Sciences

To analyze the injury characteristics of younger and older adult trauma victims. Materials and methods: This was a prospective, cross-sectional, observational, and single-center study including both younger adult and geriatric trauma patients. The relationships between the age groups and the number of consultations in the emergency department (ED) were compared with analysis of covariance after adjusting for Injury Severity Score (ISS). Results: The data consisted of 779 patients, 131 (16.8%) of whom were elderly. The intensive care unit admission rate was 7.2%. Our results showed a significantly higher incidence of intracranial hemorrhage, fracture and/or dislocation of the femur, and fracture …

Pcr Detection Of Brucella Abortus In Cow Milk Samples Collected From Erzurum, Turkey, Tüli̇n Arasoğlu, Medi̇ne Güllüce, Hakan Özkan, Ahmet Adigüzel, Fi̇kretti̇n Şahi̇n

Turkish Journal of Medical Sciences

In this study, we designed and used 2 different type-specific polymerase chain reaction (PCR) methods for the detection of Brucella abortus. Materials and methods: There were 2 different primer sets (B4/B5 and AF/AR) selected and used for the amplification of 2 different genes that are present in all biovars of Brucella species, including bcsp31, encoding 31-kDa immunogenic cell surface proteins, and omp25, which is known to be one of the virulence factors encoding outer membrane proteins of 26–23 kDa. Results: The results showed that 273 (81.7%) and 317 (94.9%) out of 334 milk samples were positive for brucellosis, as detected …

Stereological Evaluation Of Ganglion Cells In The Sigmoid Colon In Primary And Recurrent Sigmoid Volvulus, Sabri̇ Selçuk Atamanalp, Cemal Gündoğdu, Deni̇z Ünal, Zekai̇ Halici, Abdullah Kisaoğlu, Bünyami̇ Özoğul

Turkish Journal of Medical Sciences

To clarify the role of ganglion cells in Auerbach’s plexus of the sigmoid colon in the development and recurrence of sigmoid volvulus (SV). Materials and methods: Pathological block samples of colonic resection materials of 28 patients who underwent sigmoidectomy for SV and, for comparison, samples of 28 patients who underwent sigmoidectomy or low anterior resection for rectosigmoid cancer (RSC) were analyzed using stereological methods. Results: The mean numerical density of ganglion cells was significantly lower in the SV group than in the RSC group (140.70 mm^{-2} and 669.42 mm^{-2}, respectively, P = 0.005), whereas there was no significant difference between …

Incidental Findings On Electron Beam Tomography Renal Angiography In Hypertensive Patients, Baki̇ Heki̇moğlu, Begüm Demi̇rler Şi̇mşi̇r, Mustafa Şeki̇p Altunkan

Turkish Journal of Medical Sciences

To evaluate the prevalence, spectrum, and significance of incidental lesions identified on electron beam tomography (EBT) renal angiography performed to investigate renovascular hypertension. Materials and methods: EBT renal angiography images of 148 cases were evaluated in terms of renal artery variations and renal artery stenosis. Extravascular renal findings, abdominal aorta, iliac artery, liver and gallbladder findings, vertebral lesions, and other intraabdominal organ findings were assessed during the examination. Results: No incidental finding was found in 30 cases (20.2%) in total. The most frequent incidental findings were benign ones without any clinical significance. A total of 13 (8.7%) clinically significant findings …

Is There A Rise In Resistance Rates To Fosfomycin And Other Commonly Used Antibiotics In Escherichia Coli-Mediated Urinary Tract Infections? A Perspective For 2004 – 2011, Hüsnü Pullukçu, Sabi̇re Şöhret Aydemi̇r, Meltem Işikgöz Taşbakan, Oğuz Reşat Si̇pahi̇, Fatma Feri̇ha Çi̇lli̇ Hall Jr, Alper Tünger

Turkish Journal of Medical Sciences

Resistance patterns of Escherichia coli to fosfomycin, ciprofloxacin, amikacin, and cotrimoxazole were evaluated in 2 different studies held in 2004 and 2005. In this study, it was aimed to compare the changes in the susceptibility patterns of uropathogenic E. coli strains to the above-mentioned antibiotics after 6 years. Materials and methods: Between February and April 2011, E. coli strains isolated from urine samples were included prospectively in the study. Results: A total of 502 E. coli strains (358 from outpatients and 144 from inpatients) were isolated from urine specimens between February and April 2011. Extended spectrum beta-lactamase (ESBL)-producer E. coli …

Sponge In The Belly; Postoperative Imaging Findings Of Oxidized Cellulose (Surgicel^®), Arzu Pampal, Gökçe Kaan Ataç, İbrahi̇m Onur Özen, Zeki̇ye Safi̇nur Keski̇n, Bi̇llur Demi̇roğullari, Sadi̇ Gündoğdu

Turkish Journal of Medical Sciences

Surgicel is an absorbable material for local haemostasis. Its existence at surgical sites is troublesome since it interferes with the radiological images of postoperative complications. The aim of this study is to demonstrate the postoperative appearances of intraabdominal Surgicel. Materials and methods: Twelve guinea pigs were allocated to 2 groups. Animals with intraperitoneal (n = 6) and retroperitoneal (n = 6) Surgicel pieces were scanned postoperatively. Results: The density and intensity of Surgicel were compared with adjacent tissues. All retroperitoneal haemostats were hypointense compared to tissues next to them in T1W images but hyperintense compared to muscles, and 5 were …

Comparison Of The Effect Of Contrast Medium, Air, And Ozone On Ischemia/Reperfusion Injury Due To Experimental Intussusception Model, Mi̇ne Fedakar Şenyücel, Ebru Şebnem Ayva, Mustafa Kemal Aslan, Özlem Boybeyi̇, Tutku Soyer, Nurkan Aksoy, Üçler Kisa, Ahmet Murat Çakmak

Turkish Journal of Medical Sciences

To compare effects of contrast medium, air, and ozone on ischemia/reperfusion injury due to intussusception. Materials and methods: Thirty Wistar rats were allocated into five groups (n = 6). In the control group (CG), 2 cm of colonic segment, 5 cm distal to ileocecal valve, was removed. Intussusception was performed at 5 cm distal to the ileocecal valve by pushing a proximal intestinal segment distally by stile in experimental groups. One hour later, in the sham-operated group (SG), manual reduction was performed. In the reduction groups, reduction of intussusception was performed by contrast medium (CMG, 1/1 diluted omnipaqueR, infusion rate …

Double-J Stent Placement With Grasping Forceps Through Ureteroscope Working Channel: A Novel Technique, Aki̇f Koç, Ömer Bayrak

Turkish Journal of Medical Sciences

To report a new technique for the retrograde placement of a double-J stent with grasping forceps through the ureteroscope working channel. Materials and methods: In our technique, the ureteroscope is advanced to the renal pelvis or proximal location of the obstruction in the ureteral lumen; a double-J stent is then introduced into the ureteroscope working channel. The double-J stent is pushed forward until its proximal tip is seen; then the clamp over the distal tip of the pusher is opened and the guide-wire and pusher are removed from the channel, respectively. The grasping forceps is inserted into the working channel …

Anxiety, Depression, Social Phobia, And Quality Of Life In Turkish Patients With Acne And Their Relationships With The Severity Of Acne, Ahmet Öztürk, Erdem Deveci̇, Erman Bağcioğlu, Fi̇gen Atalay, Zehra Serdar

Turkish Journal of Medical Sciences

To investigate the psychiatric characteristics of acne vulgaris and the effects of the disease on quality of life. Materials and methods: We included 70 acne patients and 50 healthy controls. The Structured Clinical Interview for DSM-IV Axis I Disorders, Hospital Anxiety and Depression Scale, Liebowitz Social Anxiety Scale, Quality of Life Scale Short Form, and Acne Quality of Life Questionnaire were applied. Results: Anxiety and depression scores of the acne patients were significantly higher than those of the control group. In patients with acne, significantly higher levels of social anxiety were detected. Social anxiety levels of severe acne cases were …

The Relationship Between Hla-G Levels And Oxidative Stress Parameters In Patients With Breast Cancer, Sema Bozali̇oğlu, Nedret Kiliç, Zuhal Yildirim, Bi̇lkay Baştürk, Osman Kurukahveci̇oğlu

Turkish Journal of Medical Sciences

To investigate serum HLA-G levels and its correlation with oxidative stress and antioxidant parameters in breast cancer patients. Materials and methods: The patient group consisted of 25 individuals with breast cancer who were operated on in the General Surgery Department of Gazi University’s Faculty of Medicine. Thirty-one individuals who had no history of any kind of cancer, allergic diseases, diabetes, or rheumatic and immunological disease constituted the control group. Results: Results showed that malondialdehyde (MDA), advanced oxidation protein products (AOPPs), and HLA-G levels in the patient group were statistically and significantly high compared to the control group (P < 0.001). While vitamin C levels were significantly lower in the patient group (P < 0.05), an insignificant difference in glutathione peroxidase (GPx) and total sulfhydryl group (R-SH) levels in both groups was observed (P > 0.05). Serum …

Comparison Of 2 Different Flap Techniques In The Surgical Removal Of Bilateral Impacted Mandibular Third Molars, Banu Özveri̇ Koyuncu, Mert Zeyti̇noğlu, Erdoğan Çeti̇ngül

Turkish Journal of Medical Sciences

To estimate the effects of flap design on wound dehiscence and the postoperative side effects after the extraction of bilateral impacted mandibular third molars. Materials and methods: This study was designed as a randomized, clinical trial composed of a sample of subjects =>18 years of age who required surgical extraction of the mandibular third molars. The predictor variable was flap type. A 3-cornered flap was used on one side and a modified triangular flap was used on the other. The primary outcome variable was wound dehiscence. The secondary outcome variables were pain, swelling, and trismus. Other variables were demographic …

The Correlation Between Cardiovascular Risk And Functional Disability And Disease Activity In The Patients With Rheumatoid Arthritis, Mustafa Güler, Saadet Yazgan Umut, Teoman Aydin, Ayli̇n Rezvani̇, Emi̇ne Poyraz

Turkish Journal of Medical Sciences

To determine the cardiovascular risk (CVR) in patients with rheumatoid arthritis (RA) and its correlation with disease activity and functional ability by using the Framingham risk score (FRS) and to compare the CVR of the RA patients with the control group with the help of the FRS. Materials and methods: Seventy-four RA patients, who were in conformity with the criteria of the American College of Rheumatology, were included in this study at Bezmialem Vakıf University Hospital. A total of 39 subjects without inflammatory arthritis were included as the control group. The FRS was calculated by evaluating age, smoking habits, diabetes, …

Determining The Association Between Turkish Women’S Menopausal Symptoms And Their Marital Adjustment, Asli Si̇s Çeli̇k, Türkan Pasi̇nli̇oğlu

Turkish Journal of Medical Sciences

To determine the association between women's menopausal symptoms and their marital adjustment. Materials and methods: A descriptive cross-sectional study was conducted on 263 Turkish women chosen using an improbable randomized sampling method. A questionnaire, the Menopause Symptom Rating Scale (MSRS), and the Dyadic Adjustment Scale (DAS) were used to collect data. Percentage distributions, the t-test in independent groups, the one-way ANOVA test, Pearson correlation analysis, and the Kruskal-Wallis test were used in the evaluation of the data. Results: The mean of the overall MSRS score for women was 22.67 ± 8.06 and the mean of the overall DAS score for …

Early Diagnosis Saves Lives In Esophageal Perforations, Ayşen Taslak Şengül, Yasemi̇n Bi̇lgi̇n Büyükkarabacak, Tüli̇n Durgun Yeti̇m, Mehmet Gökhan Pi̇rzi̇renli̇, Burçi̇n Çeli̇k, Ahmet Başoğlu

Turkish Journal of Medical Sciences

Esophageal perforations are rare but highly fatal pathologies. This study aims to discuss the treatment methods for esophageal perforations. Materials and methods: Twenty-two patients who were diagnosed with esophageal perforation in the Ondokuz Mayıs University Faculty of Medicine’s thoracic surgery clinics between 2000 and 2011 were retrospectively evaluated. Results: The cause of perforation was foreign body in 17 patients, dilatation with bougie in 2, balloon dilatation in 2, and spontaneous rupture in 1. Eight patients had cervical, 12 had thoracal, and 2 had thoracoabdominal esophagus perforations. The period between perforation occurrence and treatment was longer than 24 h in 10 …

Parathyroid Hormone And Optimal Vitamin D Status In Postmenopausal Women, Hülya Yikilkan, Cenk Aypak, Süleyman Görpeli̇oğlu, Murat Di̇cle, Özde Önder

Turkish Journal of Medical Sciences

Low serum vitamin D and calcium levels as well as high parathyroid hormone (PTH) levels are the most important risk factors in osteoporosis. The aim of our study was to estimate the optimal vitamin D status needed to prevent a rise in PTH concentrations in postmenopausal women. Materials and methods: A total of 197 postmenopausal women who were at the menopausal period for at least 1 year and who had body mass indexes (BMIs) 70 years). Results: The mean age of patients was 60.8 ± 10.9 years. Serum 25-hydroxyvitamin D3 [25(OH)D3] levels were lower than 10 ng/mL in 94 patients …