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Validity And Reliability Of Automatic Range Of Motion Measurement Using The Elbow Joint Photograph, Chris Charoenlap Jan 2018

Validity And Reliability Of Automatic Range Of Motion Measurement Using The Elbow Joint Photograph, Chris Charoenlap

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Photographic-based arc of motion measurement methods required human assessors and its accuracy is depend on observer experience. Objectives: Current research proposed method of using digital image processing technique (DIPT) for measuring elbow range of motion. Methods: Participants were enrolled from students and staffs in the university. Fluoroscopic images of both elbows were taken in flexion and extension positions. Two physiotherapists performed goniometer, inclinometer and smartphone gyroscope range of motion (ROM) measurement on bilateral elbows. Photographer took elbow images in fully extension and fully flexion three times for each position with 8-megapixel smartphone camera. The extension and flexion angles were …

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Prescription Of Anti-Osteoporosis Medication Among Orthopedic Surgeon (Pam-Os Study) In Osteoporotic Hip Fracture, Piyabuth Kittithamvongs Jan 2018

Prescription Of Anti-Osteoporosis Medication Among Orthopedic Surgeon (Pam-Os Study) In Osteoporotic Hip Fracture, Piyabuth Kittithamvongs

Chulalongkorn University Theses and Dissertations (Chula ETD)

Summary: As a medication for preventing osteoporotic fracture is recommended but scarcely prescribed, this study surveyed Thai orthopedic surgeons to explore key determinants of their prescription practices. In addition to a set of well-known determinants, the patient's health insurance status could also influence the prescription practice.Purpose: Although many guidelines suggest using anti-osteoporosis medications in patients who suffered from fragility hip fractures, low rate of prescription was encountered all over the world. In this study, we aimed to explore potential determinants affecting the prescription of anti-osteoporosis medications by orthopedic surgeons.Materials and methods:Online questionnaire survey was conducted among randomly selected orthopedic surgeons …

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The Validity And Reliability Of The Patient Health Questionnaire 9 In Screening Poststroke Depression, Piyapat Dajpratham Jan 2018

The Validity And Reliability Of The Patient Health Questionnaire 9 In Screening Poststroke Depression, Piyapat Dajpratham

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Poststroke depression occurred about 30% during the first five years after stroke. Timely diagnosis and management could facilitate motor recovery and improve independence. The Patient Health Questionnaire 9 (PHQ-9) is one of the best screening tools for poststroke depression. Since specific screening tool has not yet presented in Thailand, the validity and reliability of the PHQ-9 in stroke patients is clinically essential. Objectives: To study the criterion validity and reliability of the PHQ-9 (Thai version) in screening poststroke depression by comparing to the psychiatric interview as the gold standard. Material and Methods: First ever stroke patients age 45 years …

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Significant Coronary Artery Stenosis Assessment: Diagnostic Accuracy Of Quantitative 4d-Mspect Stress Radionuclide Myocardial Perfusion Imaging, Tarit Taerakul Jan 2018

Significant Coronary Artery Stenosis Assessment: Diagnostic Accuracy Of Quantitative 4d-Mspect Stress Radionuclide Myocardial Perfusion Imaging, Tarit Taerakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

OBJECTIVES: The objective of this study was to evaluate the effectiveness of quantitative assessment of radionuclide myocardial perfusion imaging in indicating significant coronary artery stenosis. METHODS: Seven hundred and twenty patients with suspicion of coronary artery disease were retrospectively identified. All of them had undergone cardiac catheterization within the 6-month period after having one-day pharmacologic stress radionuclide myocardial perfusion scan. Important parameters were analyzed including myocardial perfusion, wall motion, wall thickening severity scores of 3 coronary artery territories and left ventricular ejection fraction values. These parameters were subsequently compared with the results of gold standard cardiac catheterization. RESULTS: Binary logistic …

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System Dynamics Analysis Of Sugar-Sweetened Beverage Taxing Effect On Sugar Consumption, Dental Health Service Utilization And Oral Health For Thai Adults And Elderly, Nipaporn Urwannachotima Jan 2018

System Dynamics Analysis Of Sugar-Sweetened Beverage Taxing Effect On Sugar Consumption, Dental Health Service Utilization And Oral Health For Thai Adults And Elderly, Nipaporn Urwannachotima

Chulalongkorn University Theses and Dissertations (Chula ETD)

Dental caries is a major oral health problem, particularly among developing countries. Almost half of Thai adults and elderly have at least one untreated dental caries. Dental caries can result in debilitating pain that affects work productivity and even the performance of daily activities. The objectives of this study are to develop system dynamics model addressing the relationship of dental caries, sugar consumption and dental health service utilization of Thai population aged 15 and older; and to estimate the changes of dental caries prevalence when the sugar-sweetened beverage tax is implemented. A multi-sector system dynamics model was developed to consolidate …

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B-Cell Activating Factor As An Immunological Marker Of Disease Outcome And Treatment Response In Patients With Chronic Hepatitis B Virus Infection, Apichaya Khlaiphuengsin Jan 2018

B-Cell Activating Factor As An Immunological Marker Of Disease Outcome And Treatment Response In Patients With Chronic Hepatitis B Virus Infection, Apichaya Khlaiphuengsin

Chulalongkorn University Theses and Dissertations (Chula ETD)

B-cell activating factor (BAFF), an important cytokine for B lymphocyte activation that implicated in the pathogenesis and disease progression chronic hepatitis B (CHB) patients. This study aimed at evaluating clinical correlation and prognostic role of plasma BAFF, BAFF receptor and related polymorphisms in patients with CHB undergoing pegylated interferon (peg-IFN) treatment and HBV-related hepatocellular carcinoma (HCC). This study shown that BAFF levels were elevated during treatment but decreased to pre-treatment levels after peg-IFN cessation in HBeAg-positive CHB patients. Patients with HCC had significantly higher BAFF levels compared with the non-HCC group and healthy controls. Moreover, the frequency of rs9514828 CT+TT …

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Characterization Of Leptospiral Extracellular Vesicles In Stress Conditions, Eakalak Phanchamnan Jan 2018

Characterization Of Leptospiral Extracellular Vesicles In Stress Conditions, Eakalak Phanchamnan

Chulalongkorn University Theses and Dissertations (Chula ETD)

Pathogenic Leptospira spp. is a causative agent of leptospirosis, a worldwide zoonosis with public health concern especially in the urban slum of metropolis and rural areas in tropical and subtropical countries. The pathogenesis of leptospirosis remains elusive. Extracellular vesicles (ECVs), which pinch off from the bacterial membranes, simultaneously harbor multiple active molecules that may serve as a secretion system, communication tool, and vaccine candidates. Recently, chemically induced leptospiral ECVs were studied and used as vaccine candidates. However, the naturally produced leptospiral ECVs has not been characterized. This study aimed to identify proteins in leptospiral ECVs produced under stress conditions including …

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Mechanisms Of Ceftriaxone Resistance In Neisseria Gonorrhoeae Isolated From Thai Patients, Naris Kueakulpattana Jan 2018

Mechanisms Of Ceftriaxone Resistance In Neisseria Gonorrhoeae Isolated From Thai Patients, Naris Kueakulpattana

Chulalongkorn University Theses and Dissertations (Chula ETD)

N. gonorrhoeae is the causative agent of gonorrhea, which is one of the most important sexually transmitted disease. The multidrug resistance in N. gonorrhoeae has been increasingly reported worldwide. The objectives of this study were to investigate the prevalence and the mechanisms of ceftriaxone resistance in N. gonorrhoeae Thai isolates, and to investigate the synergistic activities of antibiotic combinations against N. gonorrhoeae isolates with reduced susceptibility or resistance to ceftriaxone. A total of 134 N. gonorrhoeae isolates were included in this study. The resistance rates of ciprofloxacin, tetracycline, penicillin G, gentamicin, azithromycin, ertapenem, fosfomycin, cefixime, and ceftriaxone were 90.30%, 82.09%, …

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The Role Of Histone Methylation Of H3k4 In Polarization Of Macrophages Stimulated By Immune Complex And Lipopolysaccharide And Its Therapeutic Potential In Sepsis, Vichaya Ruenjaiman Jan 2018

The Role Of Histone Methylation Of H3k4 In Polarization Of Macrophages Stimulated By Immune Complex And Lipopolysaccharide And Its Therapeutic Potential In Sepsis, Vichaya Ruenjaiman

Chulalongkorn University Theses and Dissertations (Chula ETD)

Macrophage plasticity is a process that allows macrophages to switch between two opposing phenotypes based on differential stimuli. Functional plasticity of macrophages contributes to disease pathogenesis such as cancer, metabolic diseases, autoimmune diseases and systemic infections. Epigenetics plays an important role in regulating this process. Macrophages stimulated with lipopolysaccharide (LPS) (M(LPS)) produce high level of pro-inflammatory cytokines such as IL-12, TNFα and IL-6 and low level of anti-inflammatory cytokine IL-10, while macrophages stimulated with LPS in the presence of immune complex (IC) (M(IC)) produce high level of IL-10 and low level of IL-12. In this study, we investigated the plasticity …

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Comprehensive Proteomics Identification Of Ifn-Λ3-Regulated Antiviral Proteins In Hbv-Transfected Cells, Jiradej Makjaroen Jan 2018

Comprehensive Proteomics Identification Of Ifn-Λ3-Regulated Antiviral Proteins In Hbv-Transfected Cells, Jiradej Makjaroen

Chulalongkorn University Theses and Dissertations (Chula ETD)

Interferon (IFN)-λ is a relatively unexplored, yet promising anti-viral agent. IFN-λ has recently been tested in clinical trials of chronic hepatitis B, with the advantage that side effects may be limited compared with IFN-α, as IFN-λ receptors are found only in epithelial cells. To date, IFN-λ downstream signaling pathway remains largely unelucidated, particularly via proteomics methods. Here, we report that IFN-λ3 inhibits HBV replication in HepG2.2.15 cells, reducing levels of both HBV transcripts and intracellular HBV DNA. Quantitative proteomic analysis of HBV-transfected cells was performed following 24-hour IFN-λ3 treatment, with parallel IFN-α2a and PBS treatments for comparison using a dimethyl …

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The Severity Of Cryptococcus Neoformans Infection In Fc Gamma Receptor Iib Deficient Mice, Saowapha Surawut Jan 2018

The Severity Of Cryptococcus Neoformans Infection In Fc Gamma Receptor Iib Deficient Mice, Saowapha Surawut

Chulalongkorn University Theses and Dissertations (Chula ETD)

Cryptococcus neoformans, an encapsulated yeast commonly infecting the central nervous system, refers to as cryptococcal meningitis or cryptococcosis is commonly found in Thailand. C. neoformans is able to replicate, survive inside host macrophages, evade from the cells and use macrophages as a vehicle to disseminate to the target organs, a mechanism known as Trojan horse. Therefore, the containment of C. neoformans in phagocytic cell is important for host protective immunity. Cryptococcosis is common in immunocompromised host such as in patients with low CD4+ T helper cells in HIV-infection and patients taking immunosuppressive drugs. However, the incidence of cryptococcosis in healthy …

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Hsv-1 Induces Filopodia Formation In Activated T Lymphocytes, Thanayod Sasivimolrattana Jan 2018

Hsv-1 Induces Filopodia Formation In Activated T Lymphocytes, Thanayod Sasivimolrattana

Chulalongkorn University Theses and Dissertations (Chula ETD)

Herpes simplex virus type 1 (HSV-1) is a widespread pathogen, which has diverse clinical manifestations from mild localized infection to severe systemic infection. The tissue tropism of HSV-1 is mainly epithelial and mucosal cells. However, it can also multiply in T lymphocytes suggesting a cause of viremia. In this study, CD3+CD4-CD8- Jurkat T lymphocytes were used. Under activation, up-regulation of CD69 molecules on cell surface was observed. Increase yield of HSV-1 production in activated T lymphocytes was demonstrated. In addition, most of HSV-1 virion progenies from infected T lymphocytes were released extracellularly, suggesting the cause of dissemination. The mechanism which …

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Detection Of Flagellated Protozoa Belonging To The Trypanosomatidae Family In Sand Flies Collected From Songkhla Province, Southern Thailand, Komson Chinwirunsirisup Jan 2018

Detection Of Flagellated Protozoa Belonging To The Trypanosomatidae Family In Sand Flies Collected From Songkhla Province, Southern Thailand, Komson Chinwirunsirisup

Chulalongkorn University Theses and Dissertations (Chula ETD)

Autochthonous leishmaniasis cases in Thailand are increasing dramatically, the disease is caused by two major of Leishmania species; L. orientalis and L. martiniquensis. Leishmaniasis is transmitted to the vertebrate hosts through the bite of the infected female sand fly. Moreover, other trypanosomatid protozoa have also been reported in this insect vector. In 2016, Trypanosoma sp. has been detected in sand fly from Songkhla province, where the leishmaniasis case has been reported. The aims of this study are to investigate the potential vectors of trypanosomatids in this area using morphological and molecular identification based on the Cytb gene. The parasites were …

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Effect Of Chronic Paracetamol Treatment On The Alteration Of Learning And Memory In Rats, Laddawan Lalert Jan 2018

Effect Of Chronic Paracetamol Treatment On The Alteration Of Learning And Memory In Rats, Laddawan Lalert

Chulalongkorn University Theses and Dissertations (Chula ETD)

Paracetamol (acetaminophen: APAP) is widely used for treatment of pain and fever. Although APAP is well accepted as a safe drug, several studies have recently demonstrated that treatment with this drug can lead to an alteration of several neurobehaviors. However, the exact impact of the APAP treatment and the mechanisms underlying those effects are still largely unknown. The present study aimed to investigate the effect of APAP treatment on the alteration of learning and memory and the possible mechanism underlying deleterious effects induced by APAP treatment. In this study, APAP at the dose of 200 mg/kg bw was orally fed …

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Antilithogenic Efficacy Of An Innovative Beverage Hydrozitla: In Vitro And In Vivo Studies, Nalinthip Lordumrongkiat Jan 2018

Antilithogenic Efficacy Of An Innovative Beverage Hydrozitla: In Vitro And In Vivo Studies, Nalinthip Lordumrongkiat

Chulalongkorn University Theses and Dissertations (Chula ETD)

Urinary stone disease is a common urologic disease worldwide, and it is highly recurrent. Calcium oxalate (CaOx) stone is the most common type of urinary stones. The main causes of urinary stone formation include inadequate water intake, low urinary citrate excretion and increased oxidative stress. At the present day, potassium citrate is a drug of choice for preventing stone formation and recurrence. We developed a new regimen for preventing urinary stone formation, called HydroZitLa. It was in a form of concentrate in pouch. For consumption, water was added up to 500 mL and shake well before drink. Therefore, drinking of …

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The Anatomic Variation Of The Superior Peroneal Retinaculum And Inferior Peroneal Retinaculum And Its Association To Peroneal Tendon Disorders, Pimpimol Dangintawat Jan 2018

The Anatomic Variation Of The Superior Peroneal Retinaculum And Inferior Peroneal Retinaculum And Its Association To Peroneal Tendon Disorders, Pimpimol Dangintawat

Chulalongkorn University Theses and Dissertations (Chula ETD)

The precise information for SPR and IPR reattachment is essential for the prevention of recurrent symptom of peroneal tendon dislocation/subluxation. Therefore, this study was conducted to investigate the characteristics, the attachments and morphometric parameters of the SPR, IPR and the prevalence, origin and insertion of the accessory peroneal muscles, peroneal tendon tear, and related structures. The association between the peroneal tendon tear and those structures were evaluated. One hundred and nine embalmed cadaveric legs were dissected in prone position. The SPR was variable in its length, width, angle, thickness, and insertion patterns. Based on the characteristics and insertion pattern, it …

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Phosphoproteomic Analysis Of Fc Gamma Receptor Iib Deficient Macrophages In Enhancing The Severity Of Endotoxin Tolerance, Thunnicha Ondee Jan 2018

Phosphoproteomic Analysis Of Fc Gamma Receptor Iib Deficient Macrophages In Enhancing The Severity Of Endotoxin Tolerance, Thunnicha Ondee

Chulalongkorn University Theses and Dissertations (Chula ETD)

Sepsis is a severe response to systemic infection and one of the leading causes of death in patients world-wide. Bacterial endotoxin (lipopolysaccharide; LPS), is a potent inducer of inflammation that has been associated with the pathophysiology of sepsis. The repeated LPS exposure can induce a suppressive effect as refer to endotoxin tolerance. Fc gamma receptor IIb (CD32b), the only inhibitory receptor among FcGR family, associates with systemic lupus erythematosus (FcGRIIb defunctioning polymorphisms) which are commonly found in Asian populations. Because of an inhibitory nature of the signaling, endotoxin tolerance in lupus with FcGRIIb deficient (FcGRIIb-/-) is interesting and might be …

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Host And Viral Factors Influencing Disease Progression And Treatment Response In Chronic Hbv Infection, Umaporn Limothai Jan 2018

Host And Viral Factors Influencing Disease Progression And Treatment Response In Chronic Hbv Infection, Umaporn Limothai

Chulalongkorn University Theses and Dissertations (Chula ETD)

Hepatitis B virus (HBV) infection represents a major risk factor of developing chronic hepatitis, cirrhosis and hepatocellular carcinoma (HCC). The clinical outcome of HBV infection depends on complex of host and virus interactions. In this study, we found that serum HBV RNA levels has emerged as a potential viral marker for active HBV infection and may be used to evaluate response to antiviral therapy and disease progression. Serum HBV RNA levels varied among different phases of chronic HBV infection (CHB). There was a correlation between serum HBV RNA levels and amount of intrahepatic covalently closed circular DNA (cccDNA), suggesting that …

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The Difference Patterns Of Electrophysiological Properties And Effects Of Kynurenic Acid In Trigeminal Ganglion Neurons Isolated From Rats Migraine Models, Naeemah Haji-A-Sa Jan 2018

The Difference Patterns Of Electrophysiological Properties And Effects Of Kynurenic Acid In Trigeminal Ganglion Neurons Isolated From Rats Migraine Models, Naeemah Haji-A-Sa

Chulalongkorn University Theses and Dissertations (Chula ETD)

Migraine headache generates in trigeminal nociceptive system which is activated by cortical spreading depression (CSD) phenomenon. There are also some neurotransmitter changes relating to pathogenesis of migraine, one of representative examples is serotonin (5-HT) depletion that may predispose to migraine development. Trigeminal ganglion (TG) is a structure containing cell body of neurons that undertakes a role as first order neuron in trigeminal nociceptive system. Moreover, the alteration of glutamate may contribute to hyperactivity of its specific receptors, for instance N-methyl-D-aspartate (NMDA) receptor. Endogenous biomolecule, such as kynurenic acid (KYNA) which is derived form of 5-HT can inhibit NMDA receptor. Basically, …

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Anticancer Activity Of Plumbagin On Stem-Like Characteristics, Tumor Angiogenesis And Metastatic Potential In Endocrine Resistant Breast Cancer, Nithidol Sakunrangsit Jan 2018

Anticancer Activity Of Plumbagin On Stem-Like Characteristics, Tumor Angiogenesis And Metastatic Potential In Endocrine Resistant Breast Cancer, Nithidol Sakunrangsit

Chulalongkorn University Theses and Dissertations (Chula ETD)

Plumbagin (PLB), a naphthoquinone compound and vitamin K3 derivative, was shown its potent cytotoxicity and anti-invasion in anti-hormonal resistant cells through the inhibition of Snail-induced epithelial mesenchymal transition (EMT). Overexpression of Snail leads to decrease E-cadherin and increase of beta-catenin, resulting in the activation of Wnt pathway that increases cancer stem-like characteristics in these resistant cells. This study was aimed to investigate the inhibitory effects of PLB on cancer stem-like cells (CSLCs), angiogenesis and Wnt signaling-mediated cell proliferation and invasion. In addition, our study also focused on the anticancer activity of PLB in anti-hormonal resistant breast cancer in vivo. Both …

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The Study Of Nerves And Arteries Of Upper Face: Implication For Cosmetic Procedures, Dawinee Chinnawong Jan 2018

The Study Of Nerves And Arteries Of Upper Face: Implication For Cosmetic Procedures, Dawinee Chinnawong

Chulalongkorn University Theses and Dissertations (Chula ETD)

The study of nerves and arteries of upper face for avoiding injury during the forehead lift procedure was conducted to investigate the anatomical landmark and histological plane of the nerve and artery of the upper face for reduce some injuries during a consequence of forehead lift procedure. Thirty adult soft embalmed cadaveric head were dissected. The distances between the frontal branches of the facial nerve and the mid-point of zygomatic arch, lateral canthus and lateral brow were 10.52±2.41, 39.82±7.09 and 24.10±8.92 mm, respectively. The distances between the superficial temporal artery the mid-point of zygomatic arch, lateral canthus and lateral brow …

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Does Early Initiation Of Renal Replacement Therapy Have An Impact On 28-Day Mortality In Critically Ill Patients With Acute Kidney Injury With Positive Furosemide Stress Test?: A Multicenter Randomized Controlled Trial, Nuttha Lumlertgul Jan 2018

Does Early Initiation Of Renal Replacement Therapy Have An Impact On 28-Day Mortality In Critically Ill Patients With Acute Kidney Injury With Positive Furosemide Stress Test?: A Multicenter Randomized Controlled Trial, Nuttha Lumlertgul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: The timing of initiation of renal replacement therapy (RRT) in severe acute kidney injury (AKI) remains controversial, with early initiation resulting in unnecessary therapy for some patients while expectant therapy may delay RRT for other patients. The furosemide stress test (FST) has been shown to predict the need for RRT and therefore could be used to exclude low-risk patients from enrollment in trials of RRT timing. Methods: FST was performed using intravenous furosemide (1 mg/kg in furosemide-naive patients or 1.5 mg/kg in previous furosemide users). FST-nonresponsive patients (urine output less than 200 mL in 2 h) were then randomized …

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ประสิทธิผลของการใช้สื่อสังคมออนไลน์เพื่อการลดน้ำหนักในนิสิตระดับปริญญาตรีที่มีภาวะน้ำหนักเกิน, ธัมมะธิดา พัฒนพงศา Jan 2018

ประสิทธิผลของการใช้สื่อสังคมออนไลน์เพื่อการลดน้ำหนักในนิสิตระดับปริญญาตรีที่มีภาวะน้ำหนักเกิน, ธัมมะธิดา พัฒนพงศา

Chulalongkorn University Theses and Dissertations (Chula ETD)

การแก้ปัญหาเรื่องน้ำหนักเกินในประชากรถือเป็นความท้าทายที่สำคัญด้านสาธารณสุข โดยมีความสนใจที่จะนำสื่อสังคมออนไลน์ เช่น Facebook มาใช้ในการทำกิจกรรมเพื่อส่งผลให้เกิดการปรับเปลี่ยนพฤติกรรมและทำให้น้ำหนักตัวลดลง วัตถุประสงค์แรกของการศึกษานี้คือการทบทวนวรรณกรรมอย่างเป็นระบบเพื่อศึกษาประสิทธิผลของการประยุกต์ใช้กิจกรรมการลดน้ำหนักในผู้ที่มีภาวะน้ำหนักเกินและโรคอ้วนผ่านสื่อสังคมออนไลน์ที่ผ่านมา โดยการสืบค้นงานวิจัยจากฐานข้อมูล PubMed Scopus และ Cochrane Library โดยสืบค้นในช่วงปี พ.ศ. 2548-2557 เลือกงานวิจัยการทดลองแบบสุ่มที่ใช้ภาษาอังกฤษหรือไทย ภายใต้คำสำคัญที่ใช้สืบค้นเกี่ยวกับภาวะน้ำหนักเกินและการใช้สื่อสังคมออนไลน์พบว่ามีงานวิจัยที่เกี่ยวข้องจำนวน 436 บทความ และที่ผ่านเกณฑ์จำนวน 2 บทความ โดยการศึกษาดังกล่าวมีการใช้สื่อสังคมออนไลน์ คือ Facebook หรือ Twitter และพบความแตกต่างในผลการลดลงของน้ำหนักระหว่างกลุ่มทั้งที่ให้ผลอย่างมีนัยสำคัญทางสถิติและที่ไม่พบความแตกต่าง อันจะเห็นได้ว่างานวิจัยทางด้านนี้ยังมีปริมาณน้อยและผลในภาพรวมยังไม่ชัดเจน วัตถุประสงค์ที่สองของการศึกษานี้คือการทดลองเพื่อเปรียบเทียบผลของการประยุกต์ใช้กิจกรรมการลดน้ำหนักในผู้ที่มีภาวะน้ำหนักเกินในกลุ่มทดลองที่ทำกิจกรรมผ่านสื่อสังคมออนไลน์ Facebook เปรียบเทียบกับกลุ่มควบคุมที่ทำกิจกรรมแบบออฟไลน์และใช้หนังสือคู่มือเป็นสื่อ โดยใช้ระยะเวลาศึกษา 6 เดือน แบ่งเป็นช่วงทดลอง 4 เดือน และช่วงติดตามผล 2 เดือน กลุ่มตัวอย่างจำนวน 66 คนเป็นนิสิตระดับปริญญาตรีจากคณะต่าง ๆ ที่ถูกสุ่มเข้าสู่กลุ่มทดลองและกลุ่มควบคุม แต่ละกลุ่มมีอาสาสมัครจำนวน 33 คน ทั้งสองกลุ่มมีพื้นฐานกิจกรรมคล้ายกันคือการเรียนรู้จากหลักสูตรด้านโภชนาการและการออกกำลังกาย การรายงานน้ำหนักประจำวัน การได้รับคำปรึกษาจากผู้เชี่ยวชาญ และกิจกรรมการถามตอบคำถาม ส่วนที่แตกต่างคือการจัดกิจกรรมแบบออนไลน์ผ่าน Facebook หรือแบบออฟไลน์โดยใช้หนังสือคู่มือและติดต่อผ่านทางเอกสาร ข้อมูลพื้นฐานของทั้งสองกลุ่มก่อนเริ่มทดลองไม่แตกต่างกันยกเว้นรายได้เฉลี่ยต่อเดือน ผลการวิจัยพบว่ากลุ่มทดลองมีการร่วมกิจกรรมขอรับคำปรึกษามากกว่ากลุ่มควบคุมอย่างมีนัยสำคัญทางสถิติ มีการเพิ่มของคะแนนด้านความรู้อย่างมีนัยสำคัญทางสถิติเมื่อวัดตั้งแต่ก่อนทดลองจนถึงเดือนที่ 6 ทั้งสองกลุ่มมีความพึงพอใจเมื่อสิ้นสุดเดือนที่ 4 และ 6 ในระดับดีมาก และระดับ Body Mass Index (BMI) และ Weight-to-Height Ratio (WHtR) ณ เดือนที่ 4 ของกลุ่มทดลองลดลงมากกว่ากลุ่มควบคุมอย่างมีนัยสำคัญทางสถิติ Mean diff (95% Cl) เท่ากับ 0.72 (0.13,1.30) และ 0.00758 (0.00157,0.01358) ตามลำดับ แต่การลดลงไม่แตกต่างกันอย่างมีนัยสำคัญเมื่อวัด ณ เดือนที่ 6 อันแสดงให้เห็นว่าการใช้สื่อสังคมออนไลน์ Facebook สามารถส่งผลต่อการลดลงของค่า BMI และ WHtR ในช่วงการทดลองแต่ผลที่ได้อาจไม่ยั่งยืน …

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Effect Of Intraoperative Infusion Of Sufentanil Versus Remifentanil On Postoperativeshivering In Korea: A Prospective, Double-Blinded, Randomized Control Study, Ki Tae Jung, Keum Young So, In Gook Jee, Sang Hun Kim Jan 2018

Effect Of Intraoperative Infusion Of Sufentanil Versus Remifentanil On Postoperativeshivering In Korea: A Prospective, Double-Blinded, Randomized Control Study, Ki Tae Jung, Keum Young So, In Gook Jee, Sang Hun Kim

Turkish Journal of Medical Sciences

Background/aim: The number of published papers that compare the incidence of sufentanil- and remifentanil-related postoperative shivering is insufficient. We investigated the incidence of postoperative shivering after total intravenous anesthesia with either sufentanil or remifentanil in patients who underwent elective surgery. Materials and methods: Eighty-three patients, with a physical status classified as American Society of Anesthesiologists I or II, were randomly allocated to either the remifentanil-propofol (RP group, n = 40) or sufentanil-propofol (SP group, n = 43) group. The primary endpoint was the incidence of postoperative shivering 1 h after entering the recovery room. The secondary endpoints were intraoperative core …

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Detection Of The Differences In The Apparent Diffusion Coefficient Values In Differenthistopathological Types Of Malignant Breast Lesions And Comparison Of Cellular Region/Stroma Ratio And Histopathological Results, Nevi̇n Köremezli̇ Keski̇n, Pinar Balci, Işil Başara Akin, Esra Yavuz Gürkan, Ali̇ İbrahi̇m Sevi̇nç, Meri̇h Güray Durak, Ayça Erşen Danyeli̇ Jan 2018

Detection Of The Differences In The Apparent Diffusion Coefficient Values In Differenthistopathological Types Of Malignant Breast Lesions And Comparison Of Cellular Region/Stroma Ratio And Histopathological Results, Nevi̇n Köremezli̇ Keski̇n, Pinar Balci, Işil Başara Akin, Esra Yavuz Gürkan, Ali̇ İbrahi̇m Sevi̇nç, Meri̇h Güray Durak, Ayça Erşen Danyeli̇

Turkish Journal of Medical Sciences

Background/aim: This study aimed to compare the apparent diffusion coefficient (ADC) values of malignant breast lesions with different histopathological types on diffusion-weighted imaging (DWI) and the cellular region/stroma (CR/S) ratio and histopathological results. Materials and methods: Breast diffusion-weighted magnetic resonance findings of 59 patients were retrospectively analyzed for malignant breast lesions. The CR/S ratio was calculated using breast wide-excisional biopsy or mastectomy specimens. Results: Receiver operating characteristic analysis was performed for malignant lesions and subtypes. An ADC threshold of 1.260 × 10-3 mm2/s was set to detect invasive ductal carcinoma with 80.8% sensitivity and 81.4% specificity. An ADC threshold of …

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Rising Stars Of Dpld Survival: Fvc And Exercise Desaturation (A Single-Center Study), Ayperi̇ Öztürk, Oya Kayacan Jan 2018

Rising Stars Of Dpld Survival: Fvc And Exercise Desaturation (A Single-Center Study), Ayperi̇ Öztürk, Oya Kayacan

Turkish Journal of Medical Sciences

Background/aim: Diffuse parenchymal lung diseases (DPLDs) comprise a broad, heterogeneous group of diseases with common functional characteristics and a common final pathway, usually leading to irreversible fibrosis. We investigated the effects of the physiological and functional parameters and of pulmonary hypertension (PH) on survival in DPLDs. Materials and methods: The study included 158 patients with DPLDs. Patient data were examined retrospectively, and survival status was obtained through phone calls. Results: Patients were divided into five groups according to their diagnosis: idiopathic pulmonary fibrosis (IPF), non-IPF idiopathic interstitial pneumonias, connective tissue diseases, sarcoidosis, and other DPLDs. Median survival was 42.9 months. …

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Reliability And Validity Of The Turkish Version Of Pain Assessment Checklist For Seniorswith Limited Ability To Communicate (Pacslac-T), Öznur Büyükturan, Buket Büyükturan, Aysu Yeti̇ş, Mehmet İlki̇n Naharci, Nuray Kirdi Jan 2018

Reliability And Validity Of The Turkish Version Of Pain Assessment Checklist For Seniorswith Limited Ability To Communicate (Pacslac-T), Öznur Büyükturan, Buket Büyükturan, Aysu Yeti̇ş, Mehmet İlki̇n Naharci, Nuray Kirdi

Turkish Journal of Medical Sciences

Background/aim: This study aimed to assess validity and reliability of the Turkish version of Pain Assessment Checklist for Seniors with Limited Ability to Communicate (PACSLAC-T). Materials and methods: The individuals who met inclusion criteria of the study were in patients of a hospital and a long-term care facility. Mini Mental Status Exam (MMSE), Cornell Dementia Depression Scale (CDDS), Global Deterioration Scale (GDS), visual analogue scale (VAS), and PACSLAC-T were administered to all subjects. The scales were repeated with an interval of two weeks for test-retest reliability. Results: A total of 112 patients with dementia were included in the study. The …

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Multitarget Therapy Versus Intravenous Cyclophosphamide In The Induction Treatment Of Lupus Nephritis: A Metaanalysis Of Randomized Controlled Trials, Jin Deng, Lei Luo, Lin Zhu, Huan Xie, Hong-Ping Xie Jan 2018

Multitarget Therapy Versus Intravenous Cyclophosphamide In The Induction Treatment Of Lupus Nephritis: A Metaanalysis Of Randomized Controlled Trials, Jin Deng, Lei Luo, Lin Zhu, Huan Xie, Hong-Ping Xie

Turkish Journal of Medical Sciences

Background/aim: Multitarget therapy for lupus nephritis (LN) remains in its exploratory phrase and the recent evidence is insufficient. This study aimed to evaluate the efficacy and safety of mycophenolate mofetil (MMF), tacrolimus (TAC), and steroids (multitarget therapy) versus intravenous cyclophosphamide (IVC) and steroids in induction treatment of LN. Materials and methods: We searched for randomized controlled trials of MMF plus TAC versus IVC in LN using PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, the China Biology Medicine Database, and the China National Knowledge Infrastructure Database. We assessed the retrieved citations and selected studies according to predefined inclusion and …

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Usage Of News For Prediction Of Mortality And In-Hospitalcardiac Arrest Rates In A Turkish University Hospital, Özgür Atmaca, Can Turan, Pinar Güven, Hüseyi̇n Arikan, Semi̇ha Emel Eryüksel, Sai̇t Karakurt Jan 2018

Usage Of News For Prediction Of Mortality And In-Hospitalcardiac Arrest Rates In A Turkish University Hospital, Özgür Atmaca, Can Turan, Pinar Güven, Hüseyi̇n Arikan, Semi̇ha Emel Eryüksel, Sai̇t Karakurt

Turkish Journal of Medical Sciences

Background/aim: Early warning scores (EWS), widely used around the world but not yet in Turkey, are composed of physiological parameters designed to determine potentially worsening patients to perform necessary interventions in time. The aim is to determine the national EWS (NEWS) of the patients to assess the relation between this score and length of hospital stay (LOHS), transfer to the ICU, 24-h and 28-day mortality rates, and the frequency of in-hospital cardiac arrest (IHCA). Materials and methods: NEWS of all the patients in the internal medicine clinics were calculated via a point prevalence study. The LOHS, transfer to the ICU, …

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The Psychometric Evaluation Of The Turkish Version Of The Mann Assessment Of Swallowing Ability In Patients In The Early Period After Stroke, Ebru Karaca Umay, İbrahi̇m Gündoğdu, Eda Gürçay, Erhan Ari̇f Öztürk, Volkan Yilmaz, Özgür Zeli̇ha Karaahmet, Yasemi̇n Eren, Güleser Saylam, Fatma Aytül Çakci Jan 2018

The Psychometric Evaluation Of The Turkish Version Of The Mann Assessment Of Swallowing Ability In Patients In The Early Period After Stroke, Ebru Karaca Umay, İbrahi̇m Gündoğdu, Eda Gürçay, Erhan Ari̇f Öztürk, Volkan Yilmaz, Özgür Zeli̇ha Karaahmet, Yasemi̇n Eren, Güleser Saylam, Fatma Aytül Çakci

Turkish Journal of Medical Sciences

Background/aim: The Mann Assessment of Swallowing Ability (MASA) is an efficient tool that allows physicians to determine the alertness, cooperation, and respiration of patients, which are important factors when assessing swallowing . This study aimed to translate the MASA into Turkish (T-MASA) and to assess its reliability and validity in patients during the early period after a stroke . Materials and methods: The scale was administered to 141 patients in the early period after a stroke. For reliability, both internal consistency (Cronbach's alpha and corrected item-to-total correlations) and interrater reliability were analyzed. The procedures were scored by two blinded independent …

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