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Pooled Analysis Of 163 Published Tuberculous Peritonitis Cases From Turkey, Bedi̇a Mutay Suntur, Feri̇t Kuşcu

Turkish Journal of Medical Sciences

Background/aim: Tuberculous peritonitis may be di cult to diagnose due to its insidious and variable clinical manifestations as well as characteristics similar to malignancy. In this study, case reports from Turkey over the last 10 years were reviewed systematically using pooled analysis. Materials and methods: irty-four suitable articles were found and 163 tuberculous peritonitis cases were included in the study. Results: e mean age was 34.1 years (17?79 years), and 146 (98.6%) of the patients were female and 17 (10.4%) were male. e most common complaints of these patients were abdominal pain (77.4%) and abdominal distention (73.5%). Ascites in the …

The Brazelton Neonatal Behavioral Assessment Scale: A Validity And Reliability Study In A Turkish Sample, Öznur Başdaş, Emi̇ne Erdem, Ferhan Elmali, Seli̇m Kurtoğlu

Turkish Journal of Medical Sciences

Background/aim: The aim of the Brazelton Neonatal Behavioral Assessment Scale (BNBAS) is to gather a comprehensive pro le of neonatal functioning by describing the full range of neonatal behavior, including competencies and strengths, as well as di culties or deviations. is instrument has proved to be of great clinical value by detecting infants at risk for later developmental problems. is work was conducted methodologically with the aim of a Turkish validity and reliability study of the BNBAS. Materials and methods: The study was conducted in a large tertiary hospital in Turkey. After establishing content and language validity, the BNBAS was …

Human Immunodeficiency Virus And Tuberculosis Coinfection: Clinical Features And Predictors Of Mortality, Fatma Gümüşer, Merve Altinkaynak, Di̇lek Yildiz Sevgi̇, Özlem Altuntaş Aydin, Bi̇lgül Mete, Alper Gündüz, Hayat Kumbasar Karaosmanoğlu, Si̇bel Bolukçu, Ömer Fehmi̇ Tabak, Mustafa Haluk Vahaboğlu

Turkish Journal of Medical Sciences

Background/aim: This study was undertaken to identify subjects with human immunodeficiency virus and tuberculosis (HIV/TB) coinfection in a group of HIV-positive patients followed at five different healthcare centers, and to determine the demographic and clinical characteristics of these subjects as well as the predictors of mortality. Materials and methods: A database search for subjects with TB coinfection was performed among 1475 HIV-positive adult patients and a total of 66 individuals were identified with HIV/TB coinfection. Results: There were 66 patients (4.5%) with TB coinfection. Twenty-one percent (n = 14) of the patients with TB coinfection died during the study period …

Non-Naturally Occurring Porcine Reproductive And Respiratory Syndrome Virus (Prrsv) And Methods Of Using, Hiep Lai Xuan Vu, Fernando Osorio, William W. Laegreid, Asit K. Pattnaik, Fangrui Ma

Nebraska Center for Virology: Faculty Publications

A non-naturally occurring porcine reproductive and respiratory syndrome virus (PRRSV) is provided herein, and methods of making and using the non-naturally occurring PRRSV also are provided.

Diagnostic Performance Of The Faas Stroke Screening Tool Faas Stroke Screening Tool In Patients Who Presented To The Emergency Room With Neurological Symptoms, Warongporn Phuenpathom

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Rapid screening and intervention are the keys to successful early treatment of stroke. In Thailand, the conventional FAST stroke screening tool has generally been used by triage nurses to promptly detect acute stroke. However, the FAST score has a limitation in detecting posterior circulation stroke. Previous studies showed that adding ataxia could increase the sensitivity of posterior circulation stroke detection. Therefore, we studied the performance of a new stroke screening tool, the FAAS score, among acute ischemic stroke patients. Objectives: To evaluate the diagnostic performance of the FAAS score and compare the diagnostic performance between FAAS and the conventional …

City Of Faith Vertical File Finding Aid, Holy Spirit Research Center, Oral Roberts University

City of Faith

A finding aid for the City of Faith file in the Holy Spirit Vertical File located in the Holy Spirit Research Center at Oral Roberts University.

Can Nox1 Activity Initiate Parkinson's-Like Pathology In An Enteroendocrine Cell Line?, Evan Adler

Honors Undergraduate Theses

Increased attention has been given to the gut lately in a number of conditions, from maintaining health via the use of probiotics to treating Autism Spectrum Disorder. Parkinson's Disease has a history with the gut starting with the Braak hypothesis, in which eminent researcher Heiko Braak observed that the spread of Parkinson's (PD) seemed to occur along either olfactory or enteric neurons prior to reaching the substantia nigra in the midbrain, where the classical disease symptoms become evident. Though this finding was largely ignored at the time, the possibility of a gut origin for PD has received interest lately as …

Development Of A Non-Human Primate Model For Staphylococcus Aureus Nasal Carriage, Amanda Lasseter

Electronic Theses and Dissertations

Staphylococcus aureus nasal carriage (SANC) is largely asymptomatic, but presents a risk of autoinfection and dissemination to new immunocompromised hosts. SA disease states range from mild cutaneous infections to life-threatening bacteremia. Historically utilized rodent models do not naturally carry SA in the nose, are insufficient in longitudinal SANC experimentation, and lack immune factors that are vital in human clearance of SA. The nasal passages of non-human primates are similar anatomically and histologically, and reproductive mucosal studies have shown similar immune responses to pathogens and human-relevant microbial profiles. Seventeen captive pigtailed macaques (Macaca nemestrina) were found to naturally carry SA in …

Embryonic Stem Cell Derived Exosomes Enhance Cardiac Stem Cell Differentiation Into Heart Cells, Jamillah Hammond

Electronic Theses and Dissertations

Transplantation of embryonic stem (ES) cells into the ischemic and infarcted heart has proven to repopulate cardiac cell populations, attenuate structural cardiac remodeling, and rescue cardiac function. Unfortunately, the pluripotency of ES cells increases risk of teratoma formation in vivo. Exosomes, smaller in comparison to ES cells, are cell free carriers of miRNA, proteins, and lipids, and do not suggest risk of teratoma formation. Exosomes have been proposed to mediate and attenuate regeneration following myocardial infarction (MI), however, the role of exosomes derived from ES cells (ES-Exo) in activating resident cardiac stem cells (CSCs) to undergo cardiac differentiation is not …

Comparison Between Laparoscopy And Laboratory Tests For The Diagnosis Of Tuberculous Peritonitis, Bo Huang, De Jun Cui, Ying Ren, Bin Han, Da Ping Yang, Xun Zhao

Turkish Journal of Medical Sciences

Background/aim: Our study aimed to investigate a reliable diagnostic approach for tuberculous peritonitis (TBP) by comparing the commonly used diagnostic tools. Materials and methods: Fifty-one patients had received a series of diagnoses, including laparoscopy, erythrocyte sedimentation rate (ESR), cancer antigen 125 (CA125), tuberculin skin test, tuberculosis antibody in serum (TB-Ab), the T-SPOT.TB test, or adenosine deaminase (ADA) in ascitic fluid. The positive rate of each method was calculated and the differences of positive rates between laparoscopy and laboratory tests that had higher positive rates were analyzed by McNemar chi-square test. Results: The most common symptoms and signs of 51 patients …

Effects Of Epidural Morphine And Levobupivacaine Combination Before Incision And Afterincision And In The Postoperative Period On Thoracotomy Pain And Stress Response, Güler Ayşe Barut, Mehtap Tunç, Şazi̇ye Şahi̇n, Fatma Ulus, Hi̇lal Sazak

Turkish Journal of Medical Sciences

Background/aim: This study aims to investigate the effects of thoracic epidural analgesia, before and after surgical incision and in the postoperative period, on thoracotomy pain and stress response. Materials and methods: A total of 45 patients who were scheduled for posterolateral thoracotomy were included in this study. A combination of epidural levobupivacaine and morphine was administered as a bolus before incision (Group 1; n=15), after incision (Group 2; n=15), or at the end of surgery (Group 3; n=15). Additionally, infusion was used in Group 1 and Group 2 during operation. Postoperative patient-controlled epidural analgesia infusion pumps were connected to all …

Role Of Sex Chromosomes In Sexual Dimorphism Of Angii-Induced Abdominal Aortic Aneurysms, Yasir Alsiraj

Theses and Dissertations--Pharmacology and Nutritional Sciences

Abdominal aortic aneurysms (AAAs), a permanent dilation in the abdominal region of the aorta, is a highly sexually dimorphic disease. AAAs prevalence is ranging from 4-10 fold higher in males than females. Defining the mechanistic basis for reduced (in females) or increased (in males) AAA formation and progression may uncover potential therapeutic targets. The majority of studies examining sexual dimorphism focus on the role of sex hormones. However, genes residing on sex chromosomes, in addition to sex hormones, may contribute to sexual dimorphism of AAAs. For example, the X chromosome contains about 5% of the whole genome, but the role …

Gene Regulation In The Hypothalamic-Pituitary-Gonadal Axis Of The Green Anole Lizard (Anolis Carolinensis)., Joshua N. Peters

All Graduate Theses, Dissertations, and Other Capstone Projects

Studies examining the hypothalamic-pituitary-gonad axis (HPG) in Anolis carolinensis provide insight into the regulation of this axis under extremely different reproductive conditions. Molecular studies indicate that kisspeptin proteins, transcribed from kiss1 and kiss2 genes, are produced in the hypothalamus where they bind G protein-coupled receptor 54 (GPR54), activating the HPG axis. Gonadotropin inhibitory hormone (GnIH) and its receptors, G protein-coupled receptor 147 and 74 (GPR147 and GPR74), down regulate HPG axis function. In this experiment we examined HPG axis gene expression in the green anole lizard (Anolis carolinensis), a seasonally breeding species with higher steroid hormone levels in the breeding …

The Perspectives Of Men In Mexico City About Vasectomy, Isabel Vieitez Martínez, Adriana Ramos

Reproductive Health

As part of World Vasectomy Day, the Population Council Mexico conducted an exploratory study about the reasons and concerns that led men to seek a no-scalpel vasectomy (NSV) during the 24-hour “Vasectomy-athon” in Mexico City in 2017. This study was intended as the first part of a longer cohort study that would follow up with the men, and their partners, to learn about their experiences with the procedure and its effects, if any, on their relationships. Based on the findings, the report recommends that the Mexican Ministry of Health (SSA) continue integrating NSV information, counseling, and services within the National …

The Perspectives Of Men In Mexico City About Vasectomy—Brief, Isabel Vieitez Martínez, Adriana Ramos

Reproductive Health

On November 17, 2017, Mexico City took part in the global World Vasectomy Day campaign promoting men’s participation in family planning, especially through no-scalpel vasectomy (NSV). During the event the Population Council Mexico conducted an exploratory study to better understand the reasons men chose NSV, as well as their concerns before and after the procedure. The study found that the principal reason for seeking NSV among men surveyed was their achievement of a desired family size, for themselves and their partners. The study further reveals the need to disseminate information through mass media, social networks, and all levels of the …

Investigating The Relationship Between Sulcogyral Patterns And Structural And Functional Connectivity Metrics In The Orbitofrontal Cortex, Bethany M. Blass

Honors Theses

Located within the frontal lobe, the human orbitofrontal cortex (OFC) is widely known for its roles in sensory integration, emotion processing, decision-making, and goal-directed behaviors. Atypical structural organization of the OFC may explain atypical social or motivational behaviors displayed by individuals with brain disorders, such as bipolar disorder patients (BP).

The human brain can be imaged using magnetic resonance imaging (MRI) to reveal interesting aspects of the underlying brain architecture. This brain is composed of different tissue types, including gray and white matter, as well as various morphological features, including sulci & gyri. Within the OFC, the sulci can be …

Efficacy Of Adhesive Strips To Reduce Postoperative Periorbital Edema And Ecchymosis Following Rhinoplasty, Sedat Tatar, Mehmet Hakan Bulam, Selahatti̇n Özmen

Turkish Journal of Medical Sciences

Background/aim: Periorbital edema and ecchymosis may develop following rhinoplasty. The aim of this study was to assess the efficacy of adhesive strip application on the upper and lower eyelids to reduce postoperative edema and ecchymosis following rhinoplasty. Materials and methods: The eyelids of one side were randomly selected, and an adhesive strip of standard size and number was applied at the end of the operation. The strips were removed at postoperative day 3; photos of the eyes were taken at days 3 and 7. Edema and ecchymosis were graded on a scale from 1 to 4. The ecchymosis areas on …

Validity And Reliability Of The Turkish Version Of The Dsm-5 Generalized Anxiety Disorder Severity Scale For Children Aged 11-17 Years, Şermi̇n Yalin Sapmaz, Handan Özek Erkuran, Di̇lek Ergi̇n, Masum Öztürk, Nesri̇n Şen Celasi̇n, Duygu Karaarslan, Ömer Aydemi̇r

Turkish Journal of Medical Sciences

Background/aim: This study aimed to assess the validity and reliability of the Turkish version of the DSM-5 Generalized Anxiety Disorder Severity Scale - Child Form. Materials and methods: The study sample consisted of 32 patients treated in a child psychiatry unit and diagnosed with generalized anxiety disorder and 98 healthy volunteers who were attending middle or high school during the study period. For the assessment, the Screen for Child Anxiety and Related Emotional Disorders (SCARED) was also used along with the DSM-5 Generalized Anxiety Disorder Severity Scale - Child Form. Results: Regarding reliability analyses, the Cronbach alpha internal consistency coefficient …

Appraisal Of The ″Pediatric Ards: Consensus Recommendations From The Pediatric Acute Lung Injury Consensus Conference″ With The Agree Ii Instrument, Orkun Tolunay, İlknur Tolunay, Riza Di̇nçer Yildizdaş, Tamer Çeli̇k, Ümi̇t Çeli̇k

Turkish Journal of Medical Sciences

Background/aim: The ″Pediatric Acute Lung Injury Consensus Conference″ (PALICC) was convened in order to develop a taxonomy to define pediatric acute respiratory distress syndrome (ARDS). The Appraisal of Guidelines for Research and Evaluation (AGREE) assesses the quality of guidelines. The aim of this study is to evaluate the new pediatric ARDS guideline using the AGREE II instrument. To the best of our knowledge, this is the first assessment of the new pediatric ARDS clinical practice guideline in the English literature. Materials and methods: Four appraisers assessed the new pediatric ARDS guideline with the AGREE II instrument. At the end of …

Bservational Study Of Dermatological Manifestations In Patients Admitted To Atertiary Poison Center In Iran, Haleh Talaie, Soheila Nasiri, Mehdi Gheisari, Sahar Dadkhahfar, Soma Ahmadi

Turkish Journal of Medical Sciences

Background/aim: Acute unintentional and deliberate poisoning by medications and chemicals is a frequent emergency, especially in Iran. This study aimed to evaluate the frequency and character of skin findings occurring in patients with acute intentional and aunintentional poisoning. Materials and methods: This prospective observational study was performed at the Loghman Hakim Hospital Poison Center over a period of 6 months from April 2016 to September 2016. Data including patient demographics, cause of poisoning, and level of consciousness were collected. Pediatric patients (under the age of 13) and patients who died in the first hours of admission were excluded from the …

Reliability And Validity Of The Turkish Nose Obstruction Symptom Evaluation (Nose) Scale, Serdar Karahatay, Hamdi̇ Taşli, Ömer Karakoç, Ümi̇t Aydin, Türker Türker

Turkish Journal of Medical Sciences

Background/aim: e aim of this study was to validate the Turkish Nasal Obstruction Symptom Evaluation (T-NOSE) scale. Materials and methods: e NOSE scale was translated into Turkish. A prospective study was conducted involving adult subjects with nasal obstruction and a control group. e patients were divided into three groups, namely nasal septum deviation (NSD), septoplasty, and control groups. Internal consistency, test-retest reliability, validity, responsiveness, and the magnitude of the e ect of surgery were all investigated. Results: In total, 253 subjects were enrolled in the study. Cronbach?s alpha was 0.938 and 0.942 upon test and retest, respectively, which proved good …

Risk Factor Assessment For Breast Cancer In North Cyprus: A Comprehensive Case-Control Study Of Turkish Cypriot Women, Ruqiya Pervaiz, Özgür Tosun, Hasan Besim, Nedi̇me Serakinci

Turkish Journal of Medical Sciences

Background/aim: This case-control study aims to assess the strength of associations between reproductive, lifestyle, sociodemographic, and dietary factors as well as other potential breast cancer risks and breast cancer (BC) in a North Cyprus population. Materials and methods: The study includes 408 BC patients and 412 age-matched controls recruited from Near East Hospital and Dr. Burhan Nalbantoglu State Hospital in North Cyprus. Information regarding clinical and epidemiological characteristics was collected through a standardized interview. Age-adjusted odds ratios (ORs) and 95% con dence intervals (CIs) were calculated by logistic regression before and a er adjusting for the potential confounders. Results: In …

Hand Infection In Patients With Diabetes: A Series Of 17 Cases And A Pooled Analysis Of The Literature, Anil Murat Öztürk, Serhat Uysal, Ilgin Yildirim Şi̇mşi̇r, Hi̇lmi̇ Güngör, Meltem Taşbakan

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to report the clinical characteristics and the treatment outcomes of hand infections in diabetic patients and to review the literature. Materials and methods: The medical records of 17 patients with diabetic hand infections admitted to the Diabetic Foot Care Center of two di erent clinics from January 2012 to October 2017 were reviewed. To perform the pooled analysis, published series (32 studies) were searched in two international databases (www.scopus.com and www.pubmed.com). Results: Of the 17 patients (mean age 61.7 ± 8.5 years), 8 (47.1%) were female. All cases were type 2 diabetes mellitus. …

Microdeletion And Mutation Analysis Of The Shox Gene In Patients With Idiopathic Short Stature With Fish And Sequencing, Abdullati̇f Bakir, Meral Yi̇rmi̇beş Karaoğuz, Ferda Emri̇ye Perçi̇n, Esra Tuğ, Peyami̇ Ci̇naz, Mehmet Ali̇ Ergün

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to investigate the prevalence of the microdeletions and mutations of the SHOX gene in children with idiopathic short stature (ISS) by the usage of uorescence in situ hybridization (FISH) and direct sequencing technique. Materials and methods: Thirty-seven children referred to our clinic because of short stature were classi ed as having ISS a er clinical examination. Chromosome analyses, FISH analysis of the SHOX gene, and direct sequencing of the coding exons of SHOX, through the second to the sixth exon, in 24 of the 37 patients were also performed. Results: All children had …

Anxiety And Depression States Of Adolescents With Polycystic Ovary Syndrome, Hamdi̇ Ci̇han Emeksi̇z, Aysun Bi̇deci̇, Burçi̇n Nalbantoğlu, Ayşi̇n Nalbantoğlu, Cem Çeli̇k, Yasemi̇n Yulaf, Mahmut Orhun Çamurdan, Peyami̇ Ci̇naz

Turkish Journal of Medical Sciences

Background/aim: Various studies have shown that adult patients with polycystic ovary syndrome (PCOS) have higher levels of anxiety and depression compared to their normal counterparts. However, it is still unclear whether these mood disorders already exist in adolescents affected by PCOS. The aim of the present study is to assess differences in anxiety and depression levels between adolescents with PCOS and age- and body mass index (BMI)-matched controls and to determine the possible factor(s) impacting these psychological parameters in adolescents with PCOS. Materials and methods: The study included 80 adolescents with PCOS and 50 age- and BMI-matched controls. All participants …

Visfatin Levels In Hormonally Inactive Adrenal Adenoma And Their Association Withmetabolic Parameters, Alp Atasoy, Evri̇m Çakir, Süleyman Ahbab, Yasemi̇n Erdoğan Döventaş, Maci̇t Koldaş, Hayri̇ye Esra Ataoğlu, Mustafa Yeni̇gün

Turkish Journal of Medical Sciences

Background/aim: In parallel with increased frequency and higher quality of imaging techniques, the prevalence of adrenal adenoma has gradually increased. However, despite the growing incidence, the metabolic and tumorigenesis processes involved in its etiology are still unclear. Although visfatin has been reported to be associated with inflammation and tumorigenesis, its role in adrenal adenoma has not yet been investigated. Therefore, the present study was performed with an aim to evaluate visfatin levels and cardiometabolic risk factors in patients with adrenal adenoma. Materials and methods: Thirty patients recently diagnosed with adrenal adenoma along with 30 healthy participants were studied in a …

Evaluation Of Mesenteric Panniculitis With Computed Tomography: Benign Condition Orparaneoplastic Syndrome?, Ali̇ Küpeli̇, Ayşegül Cansu, Şükrü Oğuz, Süleyman Beki̇rçavuşoğlu, Süha Turkmen, Ali̇ Ahmetoğlu, Gürkan Danişan

Turkish Journal of Medical Sciences

Background/aim: This study aimed to investigate the prevalence and association of mesenteric panniculitis (MP) with other diseases and the clinicoradiological features of MP, and to examine computed tomography findings to estimate the presence of malignancy in patients with MP. Materials and methods: Between September 2012 and August 2016, we used a keyword search to identify patients diagnosed with MP. Associated diseases and malignancies of patients were recorded. Cut-off values and diagnostic efficiencies of total MP scores and short and long diameters of the greatest lymph nodes were determined. Results: Out of 22,033 patients, 309 were determined to have MP (prevalence …

Tuberculin Skin Test Response In Patients With Juvenile Idiopathic Arthritis Onanti-Tnf Therapy, Kenan Barut, Sezgi̇n Şahi̇n, Amra Adrovi̇c, Muhammet Köşker, Ömer Kiliç, Yildiz Camcioğlu, Haluk Cezmi̇ Çokuğraş, Necla Akçakaya, Betül Sözeri̇, Özgür Kasapçopur

Turkish Journal of Medical Sciences

Background/aim: The aim of this study is to evaluate the effect of biologic drugs on the tuberculin skin test in patients with juvenile idiopathic arthritis. Materials and methods: A total of 234 biologic drug-using juvenile idiopathic arthritis patients and 45 healthy controls were enrolled in the study. The tuberculin skin test results of the patients, which had been routinely provided during follow-up, were obtained from the patient files. Tuberculin skin test values of ≥ 5 mm were considered to be positive. Results: The mean diameter of tuberculin skin test induration was 4.99 ± 6.84 mm (IQR: 0-10 mm) and 7.83 …

A Comparison Of The Effects Of Perindopril Arginine And Amlodipine On Choroidal Thickness In Patients With Primary Hypertension, Erel İçel, Hali̇l İbrahi̇m İmamoğlu, Adem Türk, Aykut İçel, Nuretti̇n Akyol

Turkish Journal of Medical Sciences

Background/aim: This study aimed to investigate the effects of two different medical treatment options on choroidal thickness (CT) in patients with primary hypertension. Materials and methods: Forty newly diagnosed primary hypertension patients and 21 healthy volunteers were included. The patients were randomly divided into two subgroups. Group I started on perindopril arginine and Group II started on amlodipine. Submacular CT using optical coherence tomography (OCT) was measured before treatment and at the third and sixth months after treatment. Results: Initial mean arterial pressure (MAP) values in Groups I and II and the control group were 113.4, 109.8, and 89.4 mmHg, …

Neonatal Safety Information Reported To The Fda During Drug Development Studies., Debbie Avant, Gerri Baer, Jason N. Moore, Panli Zheng, Alfred Sorbello, Ron Ariagno, Lynne Yao, Gilbert J. Burckart, Jian Wang

Department of Pharmacology and Experimental Therapeutics Faculty Papers

BACKGROUND: Relatively few neonatal drug development studies have been conducted, but an increase is expected with the enactment of the Food and Drug Administration Safety and Innovation Act (FDASIA). Understanding the safety of drugs studied in neonates is complicated by the unique nature of the population and the level of illness. The objective of this study was to examine neonatal safety data submitted to the FDA in studies pursuant to the Best Pharmaceuticals for Children Act (BPCA) and the Pediatric Research Equity Act (PREA) between 1998 and 2015.

METHODS: FDA databases were searched for BPCA and/or PREA studies that enrolled …