Digital Commons Network^™

Detection Of Nonrandom Association Of Alleles From The Distribution Of The Number Of Heterozygous Loci In A Sample, R Chakraborty

Faculty, Staff and Student Publications

The distribution of the number of heterozygous loci in two randomly chosen gametes or in a random diploid zygote provides information regarding the nonrandom association of alleles among different genetic loci. Two alternative statistics may be employed for detection of nonrandom association of genes of different loci when observations are made on these distributions: observed variance of the number of heterozygous loci (s2k) and a goodness-of-fit criterion (X2) to contrast the observed distribution with that expected under the hypothesis of random association of genes. It is shown, by simulation, that s2k is statistically more efficient than X2 to detect a …

Genetics And Epidemiology Of Gallbladder Disease In New World Native Peoples, K M Weiss, R E Ferrell, C L Hanis, P N Styne

Faculty, Staff and Student Publications

Native peoples of the New World, including Amerindians and admixed Latin Americans such as Mexican-Americans, are highly susceptible to diseases of the gallbladder. These include cholesterol cholelithiasis (gallstones) and its complications, as well as cancer of the gallbladder. Although there is clearly some necessary dietary or other environmental risk factor involved, the pattern of disease prevalence is geographically associated with the distribution of genes of aboriginal Amerindian origin, and levels of risk generally correspond to the degree of Amerindian admixture. This pattern differs from that generally associated with Westernization, which suggests a gene-environment interaction, and that within an admixed population …

Extrathyroidal Human Biochemistry Of Monoiodotyrosine, Stanley Andrew Tan

Loma Linda University Electronic Theses, Dissertations & Projects

The existence of extrathyroidal monoiodotyrosine (MIT) has been debated because of uncertain results from measuring serum MIT. The reason is that the isotopic and chromatographic assays used have not been sensitive enough. This investigation undertook to establish the existence of MIT in serum utilizing a radioimmunoassay (RIA), to study the physiology of serum MIT, and to discover the pharmacologic effects of exogenous MIT.

MIT-binding antibody was raised in rabbits by immunization with an MIT-porcine thyroglobulin conjugate. The antiserum bound 40% of the labeled MIT at a final dilution of 1:1000. Incubation of 100 µ1 antiserum with 50 pg [^{125 …}

Effect Of Menstrual Cycle On Hedonic Response To Gustatory Stimuli, Laurie Ann O'Toole

Dissertations and Theses

The present experiment was conducted to determine the relationship between the human menstrual cycle and gustatory hedonic response. Hedonic response was defined as the perceived pleasantness or unpleasantness of a taste stimulus. Gender differences in taste hedonic have been observed; these may be due to differences in endocrine systems. Animal taste preferences are altered when reproductive hormonal status is experimentally manipulated. Previous researchers report that human females' hedonic responses to sucrose vary systematically with phase of menstrual cycle.

Metabolism In Preimplantation Mouse Embryos, Harry M. Weitlauf, Gary L. Nieder

Neuroscience, Cell Biology & Physiology Faculty Publications

The ability of preimplantation mouse embryos to utilize glucose oxidatively is controlled, in part at least, at the level of glycolysis. Various experimental observations are reviewed that indicate the regulatory mechanism in delayed implanting blastocysts involves the classic negative allosteric feedback of high levels of ATP on phosphofructokinase while the situation in 2-cell embryos appears to be more complicated. That is, in addition to the usual negative effect of ATP and citrate on phosphofructokinase, there appears to be a modification of hexokinase that prevents phosphorylation of adequate amounts of glucose and results in low levels of fructose-6-phosphate at the 2-cell …

Lifeline - City Of Faith Newsletter (May-June, 1984), Holy Spirit Research Center Oru Library

City of Faith

Lifeline vol 2, no 3 (May-June - 1984)

Lifeline is the newsletter for the employees and staff of the City of Faith Medical and Research Center. This edition includes the following articles:

• "Quick Care Meeting South Tulsans' Needs"
• "Research at the City of Faith: The Quest for a Breakthrough"
• "Diabetes Institute Tests 'Miracle' Drug"
• "Grants Provide Research in Number of Areas"
• "Alzheimer's Disease Research Fund Established"
• "Optical Clinic Focuses on Quality Eye Care"
• "The Case for City of Faith Marketing"
• "Miracles Expected in Informations Systems"
• "COF Communications Reaches Out and Touches Everyone"
• "Welcome New Employees and Staff"

1984 Spring No. 5, School Of Medicine Office Of Alumni Affairs

Medicinews

LSU Medicinews Number 5 Spring 1984 was edited by Richard M. Paddison, MD, and published by the LSU School of Medicine Office of Alumni and Continuing Education Services.

This issue consists of 16 pages.

Effect Of Membrane Filtration Of Antimalarial Drug Solutions On In Vitro Activity Against Plasmodium Falciparum, J. Kevin Baird, C. Lambros

United States Public Health Resources

Antimalarial activities ofchloroquine, mefloquine, amodiaquine, and quinine in vitro against Plasmodium falciparum were diminished as a consequence ofmembranefiltration. Filtered drug solutions gave ID₅₀ values up to 25-fold greater than those of non-filtered (ethanol-sterilized) drug solutions. Loss ofactivity byfiltration was overcome by increasing the drug concentration prior to filtration. Water solutions filtered through Millex-GSfilter units consistently showed an absorbance maximum at 277 nm, accompanied by a lesser peak at 225 nm. Water filtrates from Nucleopore and Millex-G Vfilters showed no absorbance at 277 nm and only slight absorbance was evidentfor the Gelmanfilter unit. Activity losses were attributed to extractable contaminating …

Faculty Publications 1983, Lsu Health Sciences Center New Orleans

Historical Faculty Publications

This Faculty bibliography contains 550 publications.

[3 Cortical Blood Flow And Oxygenation Abstracts], Y. Taguchi, M. Kaminogo, G. Austin

The Dr. George M. Austin Neurology Research Collection

Three presentations stapled together:

The Changes of Cortical Blood Flow and Cortical Oxygen Tension in Focal Ischemia. M. Kaminoga, M.D., Y. Taguchi, G. Austin, M.D. Conference presentation. American College of Surgeon Annual Meeting, January 28, 1984. NOTE 2nd page of this abstract not present in this file. 2nd page is present in Individual presentation posted separately.

Effect of Hypoxia and Hyperoxia of NADH Redox State and Cortical PO₂ in the Rabbit. Y Taguchi, M.D.; M. Kaminogo, M.D.; G. Austin, M.D. Conference Presentation. Southern California Chapter, American College of Surgeons, Santa Barbara, Calif, January 28, 1984.

Autoregulation of Cortical …

Lifeline - City Of Faith Newsletter (Dec, 1983), Holy Spirit Research Center Oru Library

City of Faith

Lifeline vol 2, no 2 (Oct 1983)

Lifeline is the newsletter for the employees and staff of the City of Faith Medical and Research Center. This edition includes the following articles:

• "New Pediatrics, Family Medicine Units Open"
• "COF Comes Through - The United Way"
• "Grounds Crew Makes Good First Impression"
• "Speech Pathology Proving to be Popular Addition"
• "Welcome New Employees and Staff"

Lifeline - City Of Faith Newsletter (Nov, 1983), Holy Spirit Research Center Oru Library

City of Faith

Lifeline vol 2, no 1 (Nov, 1983)

Lifeline is the newsletter for the employees and staff of the City of Faith Medical and Research Center. This edition includes the following articles:

• "Magnetic Resonance Imager Now in Use: City of Faith Pioneers New Technology"
• "Diabetes Institute Underway"
• "Bonwell Named HMO Executive Director"
• "More than Shipping and Receiving"
• COF's Magnetic Resonance Imager Arrives"
• "Yamanashi is First MRI Physicist"
• "Staff Spreads Word With TV Appearances"
• "Richter Appointed to Nat'l MS Committee"
• "Angioplasty Program Underway"
• "Welcome New Physicians"
• "Welcome New Nurses"
• "Welcome New Employees and Staff"
• "Medical Staff Members Speak"

1983 Fall No. 4, School Of Medicine Office Of Alumni Affairs

Medicinews

LSU Medical Alumni Quarterly Number 4 Fall 1983 was edited by Richard M. Paddison, MD, and published by the LSU School of Medicine Office of Alumni Affairs.

This issue consists of 16 pages.

Development Of A Mathematical Model Of Renal Function For Clinical Application, Barbara A. Holshouser

Loma Linda University Electronic Theses, Dissertations & Projects

This model describes the orthoiodohippurate (OIH) distribution and clearance in the renovascular system. The model is described by five compartments: the blood, left and right kidneys, bladder and the red blood cell compartment. Data for these compartments, except the RBC compartment, are collected with scintillation detectors monitoring OIH tagged with 1-131 as the radiopharmaceutical passes through each compartment. Time/ activity curves are plotted for the data and used as inputs to the model parameter estimation routine. The compartments are described by a set of first order ordinary differential equations solved using the Adam's methods. For parameter estimation, an iterative predictor-corrector …

Faculty Publications 1982, Lsu Health Sciences Center New Orleans

Historical Faculty Publications

This Faculty bibliography contains 513 publications.

Biochemical Characterization Of Human Thy 1, Lynda F. Bonewald

MUSC Theses and Dissertations

The present studies were undertaken in order to a) verify the presence of a human Thy 1 antigen, b) demonstrate its similarity to murine Thy 1, and c) biochemically characterize the molecule. Previously, a 25,000 molecular weight molecule had been isolated from a human T lymphoblastoid cell line, Molt 3, using isolation procedures most frequently used for the isolation of rodent Thy 1. The human Thy 1 (p25) was demonstrated to be biochemically similar to murine Thy 1.2 by molecular weight and ability to bind Lens Culinaris lentil lectin. Recently, we confirmed similarity between the murine and the human molecule …

The Utilization Of Response Surface Techniques In Survival Experiments, Leonard Edward Buchner

MUSC Theses and Dissertations

Linear regression procedures are described which give an unbiased estimate of the percent functional viability of rat polymorphonuclear leukocytes (PMN's). These statistical techniques allow discrimination between variables which result in increased PMN survival after freezing. A review of current response surface techniques was made as they relate to optimizing the functional viability of PMN's after freezing. Experimental designs based on the steepest ascent and simplex methodologies were considered. Since the hill climbing efficiency of the steepest ascent and simplex methods are comparable, the steepest ascent procedure was selected as it is more readily adaptable to a batch mode analysis.

Lifeline - City Of Faith Newsletter (Oct, 1982), Holy Spirit Research Center Oru Library

City of Faith

Lifeline 1, vol 1 (Oct 1982)

Lifeline is the newsletter for the employees and staff of the City of Faith Medical and Research Center. This edition includes the following articles:

• "Major COF Marketing Thrust Begins"
• "The State of Our Institution" by James Winslow, M.D.
• "Hospital Receives Accreditation"
• "Optical Clinic Opens"
• "Fitness Center Goes Public"
• 'New Physicians"
• "New Nurses"
• "Welcome New Residents"
• "Hinshaw Named Medical School Dean"
• "Medical School Departments Move to City of Faith"
• "City of Faith to Pioneer Pre-paid Health Care in Tulsa"

Genetically Controlled Variation Of “Acid” Beta-Galactosidase Detected In Rattus Norvegicus By Isoelectric Focusing, T C Douglas, K A Kimmel, P E Dawson

Faculty, Staff and Student Publications

Two genetically variant forms of rat "acid" beta-galactosidase were found to differ in isoelectric point and pH dependence, but not in thermostability or sensitivity to inhibition by p-mercuribenzoate (PMB). The results of two backcrosses and an intercross indicated that the isoelectric focusing phenotypes are controlled by two codominant alleles at a single autosomal locus, for which we propose the name Glb-1. No significant linkage between Glb-1 and albino (LG I), brown (LG II), or hooded (LG VI) was observed. Strain-specific differences in total levels of kidney beta-galactosidase were detected, but it is not yet known whether the variation is controlled …

Prevention And Treatment Of Stroke By Ec-Ic Bypass, George M. Austin

The Dr. George M. Austin Neurology Research Collection

Prevention and Treatment of Stroke by EC-IC Bypass. George Austin, M.D. 12 pg. Lecture given on three different dates with variations:

Thursday, Dec. 17, 1981, Cottage Hospital

Monday, Dec. 21, 1981, Santa Ynez Valley Hospital

Monday, Jan. 18, 1982, The Hospital of the Good Samaritan

T Cell Growth Factor Receptors. Quantitation, Specificity, And Biological Relevance, Richard J. Robb, Allen Munck, Kendall A. Smith

Dartmouth Scholarship

To examine directly the hypothesis that T cell growth factor (TCGF) interacts with target cells in a fashion similar to polypeptide hormones, the binding of radiolabeled TCGF to various cell populations was investigated. The results indicate that TCGF interacts with activated T cells via a receptor through which it initiates the T cell proliferative response. Internally radiolabeled TCGF, prepared from a human T leukemia cell line and purified by gel filtration and isoelectric focusing, retained biological activity and was uniform with respect to size and charge. Binding of radiolabeled TCGF to TCGF-dependent cytolytic T cells occurred rapidly (within 15 rain …

Faculty Publications 1980, Lsu Health Sciences Center New Orleans

Historical Faculty Publications

This Faculty bibliography contains 419 publications.

Theory And Measurement Of Intracranial Aneurysm Blood Flow, George Austin, R. Vasudevan

The Dr. George M. Austin Neurology Research Collection

Theory and Measurement of Intracranial Aneurysm Blood Flow. George Austin, M.D., R. Vasudevan, Ph.D. Conference presentation. International Symposium on Microneurosurgery, 1981. 2 pg.

The Coronary Distribution Zone : Mathematical Modelling Of The Left Ventricular Epicardial Surface For Area Calculation, Three-Dimensional Rotaton And Display, S. Matts E. Sjölander

Loma Linda University Electronic Theses, Dissertations & Projects

A computer model of the left ventricular (LV) epicardial surface was developed from Jang’s truncated ellipsoidal model, which has a minor to major axis ratio of 6:10. The model was applied in calculating the area of a segment of the myocardium, jeopardized by an impending occlusion of its associated artery. The endangered segment of the LV muscle was also visualized in different projections by rotations in three space and graphical displays simulating the three dimensions.

The area formula for the surface of the ideal model , a truncated prolate spheroid, was derived and used in producing maps for manual calculations …

Effects Of Withdrawing Diphenylhydantoin (Dilantin) On Matching To Sample Performance In Mentally Retarded Persons, Vicky June Davis

Masters Theses

The present study was designed to examine the effects of gradual DPH withdrawal on the matching to sample performance of three mentally retarded persons. The percentage of correct responses per session served as the dependent variable and the sample and comparison stimuli were red, green, and blue illumination of translucent response windows. The results showed that doses of diphenylhydantoin considerably lower than the suggested optimim therapeutic level can impair the performance of mentally retarded individuals on a simple discrimination task. As doses were reduced for each subject, there were increases in the percentage of correct responding with the highest percentage …

Faculty Publications 1978, Lsu Health Sciences Center New Orleans

Historical Faculty Publications

This Faculty bibliography contains 389 publications.

Distribution Of Maternal And Fetal Blood Flow Within Cotyledons Of The Sheep Placenta, Gordon G. Power, P. Steven Dale, Paul S. Nelson

Loma Linda University Electronic Theses, Dissertations & Projects

These studies explore the distribution of blood flow among small samples of placental tissue. Labeled microspheres (14 ± 1 pm) were Injected Into the left ventricle of six un-anesthetized ewes and Into the jugular vein of the fetus In utero. A total of 3,576 samples weighing 31. +11. (S.D.) mg were taken from seventeen cotyledons and counted for flow labels. Maternal and fetal flow within the cotyledons were both normally distributed with standard deviations of 44%. The maternal/ fetal flow ratio was less than 0.5 In 9% of the cotyledon, between 0.5 and 1.5 In 70%, and greater than 1.5 …

A Retrospective Survey Of Human Birth Defects As Recorded At Mcallen General Hospital In Mcallen, Texas, 1962-1972, Deana Brown

Theses and Dissertations - UTB/UTPA

Consecutive medical records of 10,622 births were viewed, January, 1962, through December, 1972, from McAllen General Hospital, McAllen, Texas. The overall incidence of birth defects was consistent with rates for the United States. Birth defects detected in Spanish surnamed were significantly higher than for non-Spanish surnamed. Spanish surnamed bore eight times more defects of the central nervous system than non Spanish surnamed. Males had significantly more defects than females, and had almost seven times more defects of the urogenital system. The most distinctive feature of this survey was the high incidence of atelectasis. Of all defective liveborn, over half had …

The Effects Of 712-Dimethylbenz (A) Anthracene On Ovarian Steroidogenesis And Uterine Growth In The Mouse, Jeffrey Lynn Clark

Biological Sciences Theses & Dissertations

It has been previously demonstrated that 7,12-dimethylbenz(a) anthracene (DMBA) is an initiator of ovarian granulosa cell tumors. It is also known that DMBA leads to destruction of primordial oocytes, and that tumor induction may involve the interaction of pituitary gonadotropins. However, the effects of DMBA on ovarian steroidogenesis and uterine growth in relation to the tumorigenic process have not been investigated. Therefore, the present study was conducted to examine these parameters using adult C57Bl/6N mice treated in proestrus and diestrus II with 0.1 ml corn oil with or without 1.5 mg DMBA and killed 44 hours later. The uteri and …

Lipoprotein Lipase Inhibitor Removal During Ultrafiltration Of Renal Failure Patients, Alisa Minear

Loma Linda University Electronic Theses, Dissertations & Projects

Plasma samples were obtained from seven hypertriglyceridemic (>150 mg/dl) chronic renal failure patients before and after regular hemodialysis. The effect of the plasma on the lipolytic activity of bovine milk lipoprotein lipase was investigated. The lipoprotein lipase activity, as measured by release of C¹⁴-labeled free fatty acid from triglyceride, was decreased 8-67% when incubated with uremic plasma as compared to the control plasma (44 mg/dl triglyceride). The inhibition noted prior to hemodialysis did not appear to be alleviated by the dialysis but subsequent treatment with an isolated ultrafiltration technique did appear to remove an inhibitory substance as …