Digital Commons Network^™

The Effect Of Swimming And Type Of Stroke On Bone Metabolism In Competitiveadolescent Swimmers: A Pilot Study, Si̇nem Akgül, Nuray Kanbur, Şükrü Alpan Ci̇nemre, Erdem Karabulut, Orhan Derman

Turkish Journal of Medical Sciences

Background/aim: Physical activity plays a key role in increasing and preserving bone mineral density (BMD). Effects on bone development associated with various nonweight-bearing sporting activities, such as swimming, are controversial. Different strokes used in swimming may also present as another factor. The aim of this study was to evaluate the effect of swimming and type of stroke on BMD in competitive adolescent athletes. Materials and methods: Seventy-nine swimmers between the ages of 10 and 21 years participated in this study. BMD was measured with dual-energy X-ray absorptiometry at the lumbar vertebrae and left proximal femur. Daily calorie intake and calcium …

Neurodegeneration In Ocular And Central Nervous Systems: Optical Coherence Tomography Study In Normal-Tension Glaucoma And Alzheimer Disease*, Muhsi̇n Eraslan, Eren Çerman, Osman Çeki̇ç, Sevcan Balci, Volkan Deri̇ci̇oğlu, Özlem Şahi̇n, Devran Süer, Biman Chabou, Emi̇ne Neşe Tuncer Elmaci

Turkish Journal of Medical Sciences

Background/aim: To evaluate, in vivo, the optical coherence tomography (OCT) of the retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) in patients with normal-tension glaucoma (NTG) and those with Alzheimer disease (AD) in comparison with healthy subjects. Materials and methods: This cross-sectional study included 18 patients with NTG, 20 with AD, and 20 control subjects. An ophthalmologic examination and OCT scans of both eyes were performed in all patients. Results: There was a significant reduction in peripapillary RNFL thickness and macular GCC thickness and a significant increase in the global loss volume (GLV) rate in both the NTG …

The Value Of Fdg-Pet/Ct By Using 3-Dimensional Stereotactic Surface Projection Software Analysis In The Differential Diagnosis Of Dementia, Esra Arslan, Özgül Ekmekçi̇oğlu, Fatma Arzu Görtan, Zeynep Funda Engi̇n Akcan, Meli̇h Engi̇n Erkan, Haci Murat Emül, Meti̇n Halaç, Tevfi̇k Fi̇kret Çermi̇k, Keri̇m Sönmezoğlu

Turkish Journal of Medical Sciences

Background/aim: To retrospectively reevaluate brain fluor-18-fluorodeoxyglucose positron emission tomography (FDG-PET) imaging studies with 3-dimensional stereotactic surface projection (NEUROSTAT) software in order to detect changes in regional brain metabolism and to find out its contribution to the final diagnosis. Materials and methods: A total of 48 cases were included in this study. According to clinical evaluation and neuropsychometric test results, there were 17 (35%) patients with probable Alzheimer disease (AD), 17 (35%) patients with probable frontotemporal dementia (FTD), and 14 (30%) patients with undefined advanced dementia. Brain FDG-PET imaging studies were interpreted visually and also using 3-dimensional stereotactic surface projection. Results: …

A Turkish 3-Center Study Evaluation Of Serum Folic Acid And Vitamin B12 Levels In Alzheimer Disease, Nuri̇ye Nuray Ulusu, Gökhan Yilmaz, Zübeyde Erbayraktar, Ahmet Turan Evli̇ce, Sevgi̇ Aras, Görsev Yener, Aslihan Avci

Turkish Journal of Medical Sciences

Background/aim: Alzheimer disease, a common proteopathy of advanced age, is characterized by cortical atrophy, neuron degeneration, neuronal loss, and accumulation of extracellular amyloid β plaques. We aimed to investigate serum vitamin B12 and folic acid levels in Alzheimer disease and other dementia patients, as a potential screening test to detect presymptomatic Alzheimer disease in Turkish patients. Materials and methods: We evaluated folic acid and vitamin B12 levels in Alzheimer disease patients as well as in other dementia and geriatric patients from Ankara, Dokuz Eylül, and Çukurova university hospitals; 290 female and male geriatric subjects were enrolled. Vitamin B12 and folic …

Evaluation Of Patency Following Revision Technique Ofhigh-Velocity Arteriovenous Fistula, Ümi̇t Halici, Mehmet Ali̇ Kaygin, Özgür Dağ, Ahmet Aydin, Hüsnü Kami̇l Li̇mandal, Ümi̇t Arslan, Eyüp Serhat Çalik, Bi̇lgehan Erkut

Turkish Journal of Medical Sciences

Background/aim: The objective of this study is to report our experience with surgical revision of dialysis access-induced ischemia syndrome. Materials and methods: Between January 2005 and July 2013, 1254 patients underwent arteriovenous fistula operation, and 86 of them [53 males, mean age: 55 ± 25 (range: 25 to 75) years; 33 females, mean age: 50 ± 20 (range: 30 to 70) years] subsequently developed steal syndrome. These patients were treated with arterial pressure-controlled polytetrafluoroethylene banding or constriction with polypropylene suturing technique. Patients were followed in the outpatient clinic at regular intervals. Results: Symptoms were not relieved during the first 15 …

Nerve Growth Factor Receptors In Dementia, Manoochehr Messripour, Abolfazl Nazarian, Azadeh Mesripour, Iman Mohammadi

Turkish Journal of Medical Sciences

Background/aim: Nerve growth factor (NGF) promotes the survival and differentiation of sensory and sympathetic neurons. Several studies have found that certain neuropathological factors stimulate NGF receptor expression and release the truncated nerve growth factor receptor (TNGFR) to biological fluids. The aim of this pilot study was to determine urine TNGFR levels in patients with dementia and to verify whether TNGFR can be used as a biomarker of dementia. Materials and methods: Twelve patients with dementia and 12 healthy individuals were asked to voluntarily participate in this study. Ages, sexes, and weights were matched. The first morning urine samples were collected …

The Evaluation Of Hypermetabolic Mediastinal-Hilar Lymph Nodes Determined Bypet/Ct In Pulmonary And Extrapulmonary Malignancies: Correlation With Ebus-Tbna, Zuhal Kandemi̇r, Ayşegül Şentürk, Eli̇f Özdemi̇r, Ni̇lüfer Yildirim, Hati̇ce Canan Hasanoğlu, Mutlay Keski̇n, Şeyda Türkölmez

Turkish Journal of Medical Sciences

Background/aim: We aimed to define the optimal SUVmax cut-off value in determination of mediastinal-hilar lymph node metastasis, by comparing positive PET/CT results with the results of endobronchial ultrasound guided transbronchial needle aspiration biopsy (EBUS-TBNA). Materials and methods: Thirty-one patients with malignancy whose PET/CT imaging revealed a hypermetabolic mediastinal and/or hilar lymph node and who had undergone EBUS-TBNA were evaluated retrospectively. Histopathology was regarded as the gold standard. The diagnostic role of PET/CT in mediastinal/hilar lymph node metastasis was investigated and compared with the results of contrast-enhanced CT. Results: When a SUVmax value of 2.5 was used, the sensitivity, positive predictive …

Decreasing The Need For Mechanical Ventilation After Surgery Forretinopathy Of Prematurity: Sedoanalgesia Vs. General Anesthesia, Ayşe Ülgey, Işin Güneş, Adnan Bayram, Recep Aksu, Ci̇hangi̇r Bi̇çer, Fati̇h Uğur, Çağatay Karaca, Adem Boyaci

Turkish Journal of Medical Sciences

Background/aim: Premature infants experience more respiratory problems after surgical procedures. We aimed to compare general anesthesia with sedation regarding the need for postoperative mechanical ventilation in infants undergoing retinopathy of prematurity (ROP) surgery. Materials and methods: Sixty patients who underwent laser surgery for ROP were included in this study. This study was performed between October 2010 and December 2012. The sedation group (Group S, n = 30) received 1 mg/kg ketamine and 1 mg/kg propofol as a bolus for induction. The patients then received an infusion of 100-150 μg kg-1 min-1 propofol and 0.25 mg kg-1 h-1 ketamine for maintenance. …

Characterization Of Klebsiella Isolates By Matrix-Assisted Laser Desorption/Ionization Time-Of-Flight Mass Spectrometry (Maldi-Tof Ms) And Determination Of Antimicrobial Resistance With Vitek 2 Advanced Expert System (Aes), Alper Karagöz, Sümeyra Acar, Hani̇fi̇ Körkoca

Turkish Journal of Medical Sciences

Background/aim: The purpose of the study was to evaluate the performance of the VITEK mass spectrometry (MS) (bioMérieux, France) system for the identification of Klebsiella spp. isolated from different sources. Moreover, while assessing the ability of the VITEK 2 automated expert system (AES) to recognize antimicrobial resistance patterns, the researchers have extended the study to compare VITEK 2 with the routine antimicrobial susceptibility testing method. Materials and methods: This study tested 51 Klebsiella spp. isolates that were isolated from environmental examples and clinical examples. Results of conventional methods and the matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) MS were compared. Then, any …

An In Vitro And In Vivo Investigation Of The Cytotoxic Effects Of Caffeic Acid (3,4-Dihydroxycinnamic Acid) Phenethyl Ester And Bortezomib In Multiple Myeloma Cells, Ertan Altayli, Özgür Koru, Önder Öngürü, Tayfun İde, Cengi̇zhan Açikel, Meral Sarper, Mualla Pinar Elçi̇, Rahşan Ilikçi Sağkan, Erhan Astarci, Duran Tok, Sali̇m Özenç, Ali̇ Uğur Ural, Feri̇t Avcu

Turkish Journal of Medical Sciences

In this study, the in vitro and in vivo effectiveness of caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester (CAPE) in combination with bortezomib, a proteasome inhibitor, was explored in multiple myeloma (MM) cells. Materials and methods: The cytotoxic effects of CAPE and bortezomib were determined by XTT cell proliferation assay. Apoptosis levels were analyzed with annexin V-fluorescein isothiocyanate, nuclear factor kappa beta (NF-\kappaB) was analyzed with electrophoretic mobility-shift assay, and interleukin (IL)-6 levels were analyzed with enzyme-linked immunosorbent assay to evaluate CAPE's mechanism of action. To investigate the in vivo effectiveness of CAPE and bortezomib, an experimental plasmacytoma model was induced …

The Long-Term Changes In Pain-Related Symptomatology Of Inguinal Hernia Following 2 Different Herniorrhaphy Techniques, Sali̇h Erpulat Özi̇ş, Işin Ünal Çevi̇k, Hati̇m Yahya Uslu, Süleyman Özdemi̇r, Kami̇l Gülpinar, Hasan Turgut Aydin

Turkish Journal of Medical Sciences

To compare the changes in pain-related symptoms of inguinal hernias from initial admission to postoperative month 6 following 2 herniorrhaphy techniques. Materials and methods: Patients with unilateral inguinal hernias were scheduled for either Lichtenstein or self-gripping polypropylene mesh repair. Patients were preoperatively evaluated with a visual analog scale (VAS) and a Turkish version of the Douleur Neuropathique 4 (DN4) questionnaire and the complaints related to pain were noted. After surgery, patients were discharged without early complications. Patients were reassessed at postoperative month 6. The late-term complaints of pain as well as neurological findings were evaluated using the VAS and the …

Toxic Potentials Of Ten Herbs Commonly Used For Aphrodisiac Effect In Turkey, Mahmoud Abudayyak, Ebru Özdemi̇r Nath, Gül Özhan

Turkish Journal of Medical Sciences

Background/aim: Sexual dysfunction is a serious problem worldwide. In Turkey, herbal products are used by some people suffering from sexual dysfunction. Despite their therapeutic advantages, some constituents of herbs are potentially toxic and pose health risks because they can be bought from the market without a prescription. Therefore, we aimed to determine the safety of herbs possessing aphrodisiac effects, chosen on the basis of their frequency of medicinal use and commercial importance in Turkey. Materials and methods: Ten herbs (Anethum graveolens, Carthamus tinctorius, Citrus aurantium, Cocos nucifera, Glycyrrhiza glabra, Melissa officinalis, Nigella arvensis, Pinus pinea, Prunus mahaleb, and Zingiber officinale) …

Short-Term Effect Of Transcatheter Aortic Valve Implantation On Qt Dispersion, Haci Ahmet Kasapkara, Hüseyi̇n Ayhan, Tahi̇r Durmaz, Telat Keleş, Cenk Sari, Serdal Baştuğ, Cemal Köseoğlu, Bi̇lge Duran Karaduman, Murat Akçay, Ni̇hal Akar Bayram, Emi̇ne Bi̇len, Engi̇n Bozkurt

Turkish Journal of Medical Sciences

Background/aim: Electrophysiological changes are observed following mechanical stretches due to pressure overload in patients with severe aortic stenosis (AS). The electrical instability occurs after depolarization and dispersion of repolarization. The aim of this study was to evaluate changes in ventricular repolarization following transcatheter aortic valve implantation (TAVI). Materials and methods: The study population included 100 consecutive patients with severe AS that underwent TAVI. Electrocardiography (ECG) was performed at baseline, immediately after TAVI, and 1 week after TAVI. Results: The mean age of the patients was 78.2 ± 7.2 years. Thirty-four (34%) of the patients were male and 66 (66%) were …

Amyloid-Related Memory Decline In Preclinical Alzheimer's Disease In Dependent On Apoe Ε4 And Is Detectable Over 18-Months, Christine Thai, Yen Ying Lim, Victor L. Villemagne, Simon Laws, David Ames, Kathryn A. Ellis, Stephanie Rainey-Smith, Ralph Martins, Colin L. Masters, Christopher C. Rowe, Paul Maruff, Australian Imaging, Biomarkers And Lifestyle (Aibl) Research Group

Research outputs 2014 to 2021

High levels of β-amyloid (Aβ) in the brain and carriage of the APOE ε4 allele have each been linked to cognitive impairment in cognitively normal (CN) older adults. The aim of this study was to investigate the relationship between cerebral Aβ level, APOE ε4 carrier status, and cognitive decline over 18 monthes, in 317 cognitively healthy (CN) older adults (47% males, 52.4% females) aged between 60 and 89 years (Mean = 69.9, SC = 6.8). Cognition was assessed using the Cogstate Brief Battery (CBB) and the California Verbal Learning Test, Second Edition (CVLT-II). Planned comparisons indicated that CN older adults …

Neural Correlates Of Episodic Memory Formation In Children And Adults, Lingfei Tang

Wayne State University Theses

The medial temporal lobe (MTL) and prefrontal cortex (PFC) are two key brain regions that support episodic memory formation in both children and adults, but the functional developmental of these regions remains unclear. In this study, we investigated the development of neural correlates of episodic memory formation using functional MRI with a subsequent memory paradigm, administered to a cross-sectional sample of 83 children and adults. We found that MTL subregions showed an age-related increase in activation supporting memory formation of complex scenes. In addition, a functionally defined scene-sensitive region in the posterior MTL also showed similar increase and predicted better …

Appropriate Timing Of Fluoxetine And Statin Delivery Reduces The Risk Of Secondary Bleeding In Ischemic Stroke Rats, Maria Helen Harley Balch, Moner A. Ragas, Danny Wright, Kenny Reynolds, Bryce Kerr, Adrian M. Corbett

Neuroscience, Cell Biology & Physiology Faculty Publications

Background: Ongoing clinical trials are testing the effect of fluoxetine delivered post-stroke where a majority of patients are taking statins. This study determined the influence of the timing of administration of fluoxetine and statin on the final infarct volume and the risk of secondary bleeding in an animal model of ischemic stroke.

Methods and findings: Ischemic strokes were induced by endothelin-1 injection into two cortical sites of 10-12 month old female rats, targeting the forelimb motor cortex. Combined medications (5 mg/kg fluoxetine and 1 mg/kg simvastatin) were orally administered either beginning 6-12 hours or 20-26 hours after stroke induction and …

Alk Alteration Is A Frequent Event In Aggressive Breast Cancers, Abdul K. Siraj, Shaham Beg, Zeenath Jehan, Sarita Prabhakaran, Maqbool Ahmed, Azhar Hussain, Fouad Al-Dayel, Asma Tulbah, Dahish Ajarim, Khawla S. Al-Kuraya

Centre for Regenerative Medicine & Stem Cell Research

Introduction: Breast cancer is the most common female malignancy worldwide and, despite improvements in treatment modalities, there are increased chances of recurrence and metastasis in a substantial number of cases and it remains one of the major causes of mortality among female cancer patients. Anaplastic lymphoma kinase (ALK) gene has been found to be altered in several solid and hematologic tumors. We aimed to comprehensively study the prevalence of ALK expression, and changes in copy number and translocation in a large cohort of breast cancer cases in a Middle Eastern population.
Methods: ALK protein expression was investigated by immunohistochemistry and …

Cyp2d7 Sequence Variation Interferes With Taqman Cyp2d6 (*) 15 And (*) 35 Genotyping., Amanda K. Riffel, Mehdi Dehghani, Toinette Hartshorne, Kristen C. Floyd, J Steven Leeder, Kevin P. Rosenblatt, Andrea Gaedigk

Manuscripts, Articles, Book Chapters and Other Papers

TaqMan™ genotyping assays are widely used to genotype CYP2D6, which encodes a major drug metabolizing enzyme. Assay design for CYP2D6 can be challenging owing to the presence of two pseudogenes, CYP2D7 and CYP2D8, structural and copy number variation and numerous single nucleotide polymorphisms (SNPs) some of which reflect the wild-type sequence of the CYP2D7 pseudogene. The aim of this study was to identify the mechanism causing false-positive CYP2D6 (*) 15 calls and remediate those by redesigning and validating alternative TaqMan genotype assays. Among 13,866 DNA samples genotyped by the CompanionDx® lab on the OpenArray platform, 70 samples were identified as …

Saying ‘No’: A Biographical Analysis Of The Experiences Of Women With A Genetic Predisposition To Developing Breast/Ovarian Cancer Who Reject Risk Reducing Surgery, Doreen Molloy

Theses: Doctorates and Masters

Background: Genetic technologies have identified some of the genes implicated in cancer susceptibility. Women with mutations in breast/ovarian cancer-susceptibility genes (BRCA1 and 2) have a lifetime combined risk of breast/ovarian cancer of more than 80%. Risk reducing surgery (RRS) reduces cancer risk by as much as 90% in high risk populations. Despite this, some BRCA1/2 mutation-positive women say no to RRS.

Purpose: To illuminate an understanding of why women at high risk of developing breast/ovarian cancer say no to risk reducing surgery (RRS).

Design: Denzin’s (1989) interpretive biography was combined with Dolby-Stahl’s (1985) literary folkloristic methodology to provide a contextualised …

Overexpression Of Human Cu/Zn Superoxide Dismutase In Mice; The Effect Of Increase Superoxide Scavenging On Autonomic Control Of The Heart., Jeffrey Hatcher

Electronic Theses and Dissertations

Dysregulation of the autonomic cardiovascular control is a complication of diseases including diabetes, hypertension, sleep apnea, and aging. A common factor in these conditions is an increase in reactive oxygen species (ROS) in neural, cardiac, and endothelial tissues. Cu/Zn superoxide dismutase (SOD1) is an intracellular anti-oxidant enzyme that catalyzes dismutation of the superoxide anion (O2.-) to hydrogen peroxide (H2O2). Expression and function of this enzyme are diminished in pathologies that impair cardiovascular autonomic control. This study employed mice overexpressing a transgene for human SOD1 (hSOD1) to determine if its overexpression would alter autonomic regulation of BP, HR, and BRS in …

The Effects Of Home-Based Pilates In Healthy College-Age Females, Betsy Donahoe-Fillmore, Mary Insana Fisher, C. Jayne Brahler

Physical Therapy Faculty Publications

Objectives: To quantify and determine the effects of Pilates on core endurance, hamstring flexibility, balance, body composition/mass and perceived stress level in healthy college age females.

Study Design: Randomized controlled trial design.

Background: Emerging research on the Pilates technique is inconclusive regarding benefits to core endurance, flexibility, balance, body mass, and perceived stress.

Methods and Measures: Female college students (n=57; 18-35 years old) were randomly assigned to a Pilates group, who exercised at home with a DVD, or a control group who did not engage in Pilates practice. Core endurance, hamstring flexibility, balance, body composition and stress measurements were taken …

High Definition Transcranial Direct Current Stimulation Als Mogelijke Hulp Bij Afasie-Herstel, Dirk B. Den Ouden

Communication Sciences and Disorders Faculty Articles and Research

Samenvatting

Nieuwe kennis over het plastische vermogen van het volwassen brein, ook na hersenschade, heeft geleid tot hernieuwde interesse in technieken om deze plasticiteit fysiek te sturen. Een van die technieken is transcranial Direct Current Stimulation (tDCS), waarmee de exciteerbaarheid van hersencellen beïnvloed wordt door een zwakke gelijkstroom door de hersenschors te leiden. Als met deze methode hersenplasticiteit bevorderd en gestuurd kan worden, is het wellicht mogelijk om de uitkomsten van afasietherapie te verbeteren, door het aanpakken van de fysieke bron van de stoornis. Dit artikel behandelt kort de geschiedenis en de werking van tDCS, alvorens een overzicht te geven …

Effect Of Keratinocyte Growth Factor On Growth And Transdifferentiationof Primary Alveolar Epithelial Type Ii Cells, Xiuxiang Liu, Zhichun Feng, Chunmei Tian, Xiangyong Kong, Yumei Wu, Changjun Lv

Turkish Journal of Medical Sciences

Background/aim: To investigate the effects of keratinocyte growth factor (KGF) on the growth and transdifferentiation of primary alveolar epithelial type II cells (AECIIs). Materials and methods: The number of primary AECIIs, their viability, and cell cycle and apoptosis were studied under KGF treatment using a hemocytometer, trypan blue exclusion, and flow cytometry, respectively. Positive expressions of surfactant protein C (SP-C), aquaporin 5 (AQP5), and thyroid transcription factor 1(TTF-1) were examined with indirect immunofluorescence; mRNA levels of SP-C, AQP5, and TTF-1 were determined by polymerase chain reaction. Results: In response to KGF treatment, cell numbers were significantly increased, more cells were …

Nutritional Issues In Dementia Patients, Mustafa Kemal Kiliç, Fati̇h Sümer, Zekeri̇ya Ülger

Turkish Journal of Medical Sciences

Dementia is an inevitable disease of aging, leading not only to diminished cognitive ability but also behavioral changes, malnutrition, pressure sores, and infections. Acknowledging common problems and their solutions is essential for any health service worker who deals with demented geriatric patients.

Is Alzheimer Disease Related To Age-Related Macular Degeneration?, Seden Demi̇rci̇, Ali̇me Güneş, Kadi̇r Demi̇rci̇, Serpi̇l Demi̇rci̇, Levent Tök, Özlem Tök

Turkish Journal of Medical Sciences

Background/aim: To compare the cognitive functions and define the frequency of Alzheimer disease (AD) between participants with and without age-related macular degeneration (AMD). Materials and methods: Fifty-nine patients with late-stage AMD (74.3 ± 7.3 years) and 49 age-, sex-, and education-matched control subjects were compared for the presence of AD according to the guidelines of the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA). Detailed neuropsychological tests were performed for all subjects. Results: Neuropsychiatric tests scores were lower in the AMD group than the control group. The frequency of AD …

Impaired Cognitive Performance And Hippocampal Atrophy In Parkinson Disease, Demet Yildiz, Sevda Erer, Mehmet Zari̇foğlu, Bahatti̇n Hakyemez, Mustafa Bakar, Necdet Karli, Zeynep Ni̇gar Varlibaş, Fati̇h Tufan

Turkish Journal of Medical Sciences

Background/aim: Dementia is common in Parkinson disease (PD). Since magnetic resonance imaging has been used, hippocampal atrophy has been shown in PD patients with or without dementia. In this study we sought the correlation of cognitive decline with bilateral hippocampal volume in PD patients. Materials and methods: Thirty-three patients with diagnosis of idiopathic PD and 16 healthy subjects were included in this study. PD patients were divided into two groups as normal cognitive function and mild cognitive impairment (MCI). The Mini-Mental State Examination and detailed cognitive assessment tests were performed for all patients for cognitive analyses. Depression was excluded by …

Histopathological Findings Obtained From Reduction Mammoplasty Specimens, Aynur Albayrak, Çi̇ğdem Güler Mesci̇, Gülnur Güler

Turkish Journal of Medical Sciences

Background/aim: Reduction mammoplasty is a common surgical procedure. We report the incidence of nonproliferative and proliferative breast lesions in breast reduction specimens from a single institution over a 6-year period. Materials and methods: The histopathology reports of all patients were analyzed. The clinical and histopathological findings of the patients were recorded. Results: Between 2004 and 2010, 106 patients underwent breast reduction. Fifty-six patients (52.8%) had proliferative breast lesions, 84 patients (79.2%) had nonproliferative lesions, 8 patients (7.5%) had columnar cell lesions without atypia, 61 patients (57.5%) had columnar cell lesions with atypia, 5 patients (4.7%) had atypical ductal hyperplasia, and …

The Skeletal Muscle Molecular Clock Regulates The Timing Of Substrate Metabolism And The Circadian Expression Of Titin-Cap, Brian A. Hodge

Theses and Dissertations--Physiology

Skeletal muscle is a major contributor to whole-body metabolism as it serves as a depot for both glucose and amino acids, and is a highly metabolically active tissue. An intrinsic molecular clock mechanism exists within skeletal muscle that regulates the timing of physiological processes. A key function of the clock is to regulate the timing of metabolic processes to anticipate time of day changes in environmental conditions. The purpose of this study was to identify metabolic genes that are expressed in a circadian manner and determine if these genes are regulated downstream of the intrinsic molecular clock by assaying gene …

Global-Scale Analysis Of The Dynamic Transcriptional Adaptations Within Skeletal Muscle During Hypertrophic Growth, Tyler Kirby

Theses and Dissertations--Physiology

Skeletal muscle possesses remarkable plasticity in responses to altered mechanical load. An established murine model used to increase mechanical load on a muscle is the surgical removal of the gastrocnemius and soleus muscles, thereby placing a functional overload on the plantaris muscle. As a consequence, there is hypertrophic growth of the plantaris muscle. We used this model to study the molecular mechanisms regulating skeletal muscle hypertrophy.

Aged skeletal muscle demonstrates blunted hypertrophic growth in response to functional overload. We hypothesized that an alteration in gene expression would contribute to the blunted hypertrophic response observed with aging. However, the difference in …

Morphometric Analysis Of Left & Right Tonsils In Adult Symptomatic Type 1 Chiari Patients And Healthy Controls, Louis J. Konstan

Williams Honors College, Honors Research Projects

Historically, CMI has been radiographically defined by cerebellar tonsillar descent below the foramen magnum (FM) more than 5 mm (2). This measurement is typically made with a single sagittal plane T1-or T2-weighted MR image. Studies have obtained additional morphometric measurements to help diagnose CMI, and establish normal values (3,4). These studies were somewhat These studies were somewhat successful in differentiating CMI patients from healthy subjects. However, results from these studies have shown that the standard TD measurement does not necessarily correlate with neurological symptom severity as patients with CMI-like symptoms have been found with a TD of less than 5 …