Open Access. Powered by Scholars. Published by Universities.®
- Institution
-
- The Texas Medical Center Library (6136)
- TÜBİTAK (1019)
- Thomas Jefferson University (505)
- University of Alabama at Birmingham (385)
- University of Kentucky (326)
-
- University of Nebraska - Lincoln (261)
- Chapman University (211)
- Dartmouth College (187)
- Chulalongkorn University (183)
- General Organization of Teaching Hospitals and Institutes (GOTHI) (169)
- Virginia Commonwealth University (164)
- University of Nebraska Medical Center (154)
- LSU Health New Orleans (147)
- Edith Cowan University (123)
- Zucker School of Medicine at Hofstra/Northwell (116)
- Marshall University (105)
- Marquette University (103)
- University of Tennessee Health Science Center (101)
- City University of New York (CUNY) (97)
- Wright State University (94)
- Old Dominion University (87)
- Wayne State University (87)
- University of South Carolina (82)
- Himmelfarb Health Sciences Library, The George Washington University (77)
- Children's Mercy Kansas City (76)
- University of Nevada, Las Vegas (71)
- Loma Linda University (69)
- University of Texas Rio Grande Valley (62)
- University of Central Florida (57)
- University of South Florida (57)
- Keyword
-
- Humans (4048)
- Female (1685)
- Male (1527)
- Animals (1456)
- Mice (1038)
-
- Adult (772)
- Middle Aged (718)
- Aged (594)
- Child (450)
- Doctor of Philosophy (PhD) Heersink School of Medicine (358)
- Adolescent (334)
- Mutation (314)
- Tumor (299)
- Neoplasms (295)
- Biomarkers (287)
- Retrospective Studies (276)
- Brain (257)
- Cell Line (230)
- Young Adult (220)
- Infant (217)
- Receptors (215)
- Carcinoma (213)
- Animal (212)
- Magnetic Resonance Imaging (206)
- Mice, Inbred C57BL (205)
- Inbred C57BL (203)
- Treatment Outcome (203)
- Gene Expression Regulation (202)
- Genome-Wide Association Study (200)
- Risk Factors (197)
- Publication Year
- Publication
-
- Faculty, Staff and Student Publications (3075)
- Faculty, Staff and Students Publications (2492)
- Turkish Journal of Medical Sciences (1019)
- All ETDs from UAB (383)
- Dartmouth Scholarship (185)
-
- Chulalongkorn University Theses and Dissertations (Chula ETD) (178)
- Journal of Medicine in Scientific Research (169)
- Theses and Dissertations (167)
- Children’s Nutrition Research Center Staff Publications (159)
- Journal Articles (116)
- Dissertations and Theses (Open Access) (113)
- Duncan NRI Faculty and Staff Publications (99)
- Pharmacy Faculty Articles and Research (99)
- Theses and Dissertations (ETD) (99)
- Electronic Theses and Dissertations (97)
- Department of Pathology, Anatomy, and Cell Biology Faculty Papers (91)
- School of Veterinary and Biomedical Sciences: Faculty Publications (91)
- Biomedical Sciences Faculty Research and Publications (90)
- Department of Biochemistry and Molecular Biology Faculty Papers (84)
- Center for Medical Ethics and Health Policy Staff Publications (83)
- Manuscripts, Articles, Book Chapters and Other Papers (76)
- Publications and Research (73)
- Research outputs 2022 to 2026 (69)
- Nebraska Center for Virology: Faculty Publications (67)
- School of Medicine Faculty Publications (61)
- Loma Linda University Electronic Theses, Dissertations & Projects (58)
- UNLV Theses, Dissertations, Professional Papers, and Capstones (57)
- Journal Articles: Biochemistry & Molecular Biology (51)
- Mansoura Journal of Dentistry (50)
- BioMedicine (46)
- Publication Type
- File Type
Articles 10531 - 10560 of 13155
Full-Text Articles in Entire DC Network
A Few Notes On Nabokov's Childhood Entomology, Victor Fet
A Few Notes On Nabokov's Childhood Entomology, Victor Fet
Biological Sciences Faculty Research
Nabokov's lepidoptery long posed a question: Was he an amateur or a professional entomologist? Today, it has been amply demonstrated that he was a professional. Kurt Johnson says, "For Nabokov, as with many, fascination with the big picture books of butterflies as a young child grew to concerted collecting as a youngster. As with many scientists, these impressions of youth become a driving life force."3 Nabokov started collecting butterflies in 1906, at age seven, and never ceased; he published his first book of poems ten years later, at age seventeen; his first research paper on butterflies, at age twenty; …
Ribosomal Protein L12 (Rpl12) As A Novel Target In Cystic Fibrosis, Kathryn E. Oliver
Ribosomal Protein L12 (Rpl12) As A Novel Target In Cystic Fibrosis, Kathryn E. Oliver
All ETDs from UAB
Approximately 1,000 new cases of cystic fibrosis (CF) are diagnosed in the United States every year. The disease is caused by over 1,700 naturally occurring variants in the CF transmembrane conductance regulator (CFTR). Defects in the CFTR coding sequence contribute to variable disease severity in the patient population. The majority of individuals born with CF harbor at least one specific mutation in CFTR termed F508del. Clinical manifestations of CF include severe damage of multiple exocrine tissues, including the lungs, intestine, pancreas, reproductive and other organ systems. An overarching goal of our work is to identify cellular targets that contribute to …
Cd4 Regulatory T Cells Augment Hiv-1 Expression Of Polarized M1 And M2 Monocyte Derived Macrophages, Tanya Robinson
Cd4 Regulatory T Cells Augment Hiv-1 Expression Of Polarized M1 And M2 Monocyte Derived Macrophages, Tanya Robinson
All ETDs from UAB
Polarization of macrophages is critical for an effective host immune response against invading pathogens. However, the HIV-1 virus can alter the cytokine/chemokine profile of polarized macrophages which may ultimately lead to their increased susceptibility to viral infection. M1 monocyte-derived macrophages (MDM) have been shown to suppress CCR5-tropic HIV-1 replication, while M2 MDM promote it. We generated M1 (GM-CSF + IFN-γ + LPS) and M2 (M-CSF + IL-4) MDM with predicted phenotypes and exposed them to a CCR5 (R5) “highly macrophage-tropic” viral strain, HIV-1BaL. M2 MDM had notably higher levels of HIV-1 infection than M1 MDM. We also investigated R5 HIV-1 …
Atp6v1c1 Enhances Breast Cancer Growth By Activating V-Atpase Mediated Mtorc1 Signaling And Metastasis By Increasing V-Atpase Activity In Cancer Cells, Matthew J. Mcconnell
Atp6v1c1 Enhances Breast Cancer Growth By Activating V-Atpase Mediated Mtorc1 Signaling And Metastasis By Increasing V-Atpase Activity In Cancer Cells, Matthew J. Mcconnell
All ETDs from UAB
It is known that the vacuolar ATPase has a number of functions related to tumor growth and progression such as involvement in drug resistance, pH regulation, autophagy, and lysosomal acid protease activation, as well as invasion and metastasis. Here we specifically describe the role of ATP6v1c1 in murine and human models of breast cancer. ATP6v1c1 is the dominant isoform of the coordinating subunit (ATP6v1c) involved in the assembly of the vacuolar ATPase complex which plays a key role in cancer growth and progression. We also describe how ATP6v1c1 knockdown impairs tumor nutrient signaling through mTORC1 and tumor cell proliferation, by …
Neurodevelopmental Alterations In A Rodent Model Of Temperamental Differences, Chelsea Mccoy Mccoy
Neurodevelopmental Alterations In A Rodent Model Of Temperamental Differences, Chelsea Mccoy Mccoy
All ETDs from UAB
Understanding biological mechanisms that shape brain development and susceptibility to emotional dysfunction is crucial for generating improved treatments for depression and anxiety disorders. To study neurodevelopmental factors that influence emotionality, we use model rats that were bred for distinct behavioral responses to novelty. Rats bred for low novelty response (LRs) exhibit a high anxiety-/depressive-like phenotype compared to high novelty responder rats (HRs), which vigorously explore novelty and exhibit high impulsivity, aggression, and risk-taking. Transcriptome profiling revealed multiple gene expression differences in the early postnatal hippocampus and amygdala and in the adult amygdala of HR/LR rats. Through gene ontology analysis, we …
Exploring Bacteriophage P22 As A Selective Molecular Scaffold And Molecular Sensor, Gregory Joseph Bedwell
Exploring Bacteriophage P22 As A Selective Molecular Scaffold And Molecular Sensor, Gregory Joseph Bedwell
All ETDs from UAB
The virus capsids of many dsDNA bacteriophage are finely tuned macromolecular machines. Their functionality begins at assembly, when their capsids are built under the guidance of a class of proteins referred to as scaffolding proteins. The scaffolding protein of bacteriophage P22 is a flexible, highly elongated protein that binds to the interior surface of the P22 procapsid via its C-terminal domain. The finding that N-terminus is dispensable for procapsid binding prompted the development of chimeric scaffolding protein molecules, wherein N-terminal residues of scaffold are replaced with a variety of different peptide sequences or functional proteins that are then encapsidated within …
Structure-Function Relationships In The Sec7 Guanine Nucleotide Exchange Factor Gbf1, Jay Manoj Bhatt
Structure-Function Relationships In The Sec7 Guanine Nucleotide Exchange Factor Gbf1, Jay Manoj Bhatt
All ETDs from UAB
All eukaryotic cells contain a secretory pathway composed of membrane-bound compartments connected by vesicles that transport cargo from the endoplasmic reticulum (ER) through the Golgi apparatus to various destination within and outside the cell. The Golgi Brefeldin A-resistant Factor 1 (GBF1) is required for protein traffic between ER and Golgi and within the Golgi. GBF1 belongs to a family of Guanine nucleotide Exchange Factors (GEFs) that stimulate the nucleotide exchange of GDP for GTP on small GTPases called ADP-ribosylation factors (ARFs). Once GTP-bound, ARFs become active and initiate a cascade of events that lead to vesicle formation. Thus, GBF1 is …
The Impact Of Rrna And Trna Synthesis On Chromatin Structure And Cell Fate, Jessica Makofske Woolnough
The Impact Of Rrna And Trna Synthesis On Chromatin Structure And Cell Fate, Jessica Makofske Woolnough
All ETDs from UAB
The Central Dogma of molecular biology describes the process by which genetic material is faithfully converted into functional molecules across all domains of life. Originally, RNA was solely understood as an intermediate in this process. However, mounting evidence over the past 50 years has made clear that RNA have diverse functional roles as a class of molecule termed non-coding RNA. Two of the first described non-coding RNA have essential roles within the Central Dogma, itself: ribosomal RNA (rRNA) and transfer RNA (tRNA). These two non-coding RNA are highly abundant, collectively accounting for up to 90% of the total transcript in …
Human Cytosolic Sulfotransferase (Sult) 1b1 Half-Site Reactivity And The Identification And Characterization Of A Novel Variant Sult1b1 Isoform (L145v), Zachary Evan Tibbs
Human Cytosolic Sulfotransferase (Sult) 1b1 Half-Site Reactivity And The Identification And Characterization Of A Novel Variant Sult1b1 Isoform (L145v), Zachary Evan Tibbs
All ETDs from UAB
The human cytosolic sulfotransferases (hSULTs) are a fourteen-member family of phase II drug-metabolizing enzymes that catalyze the transfer of a sulfonate moiety from 3’-phosphoadenosine 5’-phosphosulfate (PAPS) to a recipient substrate. SULT-mediated sulfation serves to deactivate physiological hormones and detoxify xenobiotics. SULT1B1 is primarily resident to the gastrointestinal tract, liver, and possibly peripheral white blood cells (WBCs), whereby it performs its supposed physiological role. The iso-form has the capacity to sulfate thyroid hormones, small phenols, and polyaromatic hy-drocarbons resulting in their inactivation, detoxification, and bioactivation/detoxification, respectively. Immunohistochemistry was used to show hSULT1B1 protein is present in periph-eral lymphocytes and neutrophils. Further, …
Germline Restriction Of B Cell Receptor Repertoire Influences Antigenic Epitope Recognition And Primary Antibody Deficiency Pathogenesis, Yuge Wang
All ETDs from UAB
Part I. Mouse Studies Complementarity determining region 3 of the immunoglobulin (Ig) H chain (CDR-H3) lies at the center of the antigen binding site where it often plays a decisive role in antigen recognition and binding. Amino acids encoded by the diversity (DH) gene segment are the main component of CDR-H3. Each DH has the potential to rearrange into one of six DH reading frames (RFs), each of which exhibits a characteristic amino acid hydrophobicity signature that has been conserved among jawed vertebrates by natural selection. A preference for use of RF1 promotes the incorporation of tyrosine into CDR-H3 while …
Cell Signaling Pathways As Targets For Precision Medicine In Head And Neck Squamous Cell Carcinoma, Alice Weaver
Cell Signaling Pathways As Targets For Precision Medicine In Head And Neck Squamous Cell Carcinoma, Alice Weaver
All ETDs from UAB
Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous disease with high rates of recurrence and mortality. Unlike other cancer types, genome sequencing studies have failed to produce clinically actionable targets to improve HNSCC management. Therefore, alternative methods are needed to study the molecular mechanisms responsible for disease progression and response to therapy. The focus of this research was to determine how dysregulation of cell signaling pathways affects outcomes in HNSCC. In HPV-positive HNSCCs, we hypothesized that HPV induces dysregulation of the DNA damage response which mediates differences in therapeutic sensitivity and survival. We identified a defect in DNA …
Structural Basis For Lipid-And Calmodulin-Mediated Akt Activation In Breast Cancer Cells, Constance Agamasu
Structural Basis For Lipid-And Calmodulin-Mediated Akt Activation In Breast Cancer Cells, Constance Agamasu
All ETDs from UAB
Growth and survival signals initiated at the cell surface by receptor-ligand interactions often involve a downstream activation of Akt, a serine/threonine kinase critical in regulating cell survival, apoptosis and oncogenesis. Hyper-activation of Akt is a common tumorigenic event, thereby making the Akt activation pathway a prime target for cancer therapy. The translocation of Akt to the plasma membrane (PM) for phosphorylation is a critical step in the Akt activation pathway. It has been established that membrane binding of Akt is mediated by direct interactions between its pleckstrin homology domain (PHD) and membrane lipid phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3]. There is now emerging …
Role Of Autocrine And Paracrine Wnt Signaling In Chronic Myeloid Leukemia Stem Cells, Puneet Agarwal
Role Of Autocrine And Paracrine Wnt Signaling In Chronic Myeloid Leukemia Stem Cells, Puneet Agarwal
All ETDs from UAB
Treatment of chronic myeloid leukemia (CML) with BCR-ABL tyrosine kinase inhibitors (TKIs) fails to eradicate the leukemia stem cells (LSCs) from which the disease arises. Previously, we and others have shown that LSC persistence is related to kinase-independent mechanisms and mediated in part by signals from the bone marrow microenvironment (BMM). Specifically, we found that WNT signaling from the BMM may contribute to preservation of CML LSC following TKI treatment. Wnt secretion and activity requires their palmitoylation by the Porcupine acyltransferase (PORCN). WNT974 (formerly LGK974) is a potent PORCN inhibitor that blocks WNT signaling and demonstrates in vivo efficacy against …
Copper Chaperone In Streptococcus Mutans Biofilm Formation And Dispersion Of Biofilms By Small Molecules, Sandra Stephanie Garcia
Copper Chaperone In Streptococcus Mutans Biofilm Formation And Dispersion Of Biofilms By Small Molecules, Sandra Stephanie Garcia
All ETDs from UAB
program pilot study randomly assigned 100 women, aged 19 to 25 to two groups. One
The Use Of Neuroscience Evidence In Criminal Proceedings, John B. Meixner Jr.
The Use Of Neuroscience Evidence In Criminal Proceedings, John B. Meixner Jr.
Scholarly Works
While law and neuroscience has been an increasingly popular topic in academic discourse, until now, little systematic research had examined how neuroscience evidence has actually been used in court. Do courts actually admit and consider evidence of brain trauma that might indicate that an individual did not have the capacity to achieve the mental state required for conviction of particular crime? Do they use such evidence to consider the relative culpability for the crime in the event of conviction? Do they consider or understand brain scan data? For much of the life of this infant field, we have only been …
Decision Making And The Law: Truth Barriers, Jonathan J. Koehler, John B. Meixner Jr.
Decision Making And The Law: Truth Barriers, Jonathan J. Koehler, John B. Meixner Jr.
Scholarly Works
Reaching an accurate outcome is a central goal of the American trial. But structural features of the legal system, in combination with the cognitive shortcomings of legal actors, hinder the search for truth. Regarding the legal system, various rules and policies restrict decision makers’ access to evidence, violate the laws of probability, and limit the evidentiary concerns that may be considered on appeal. Regarding legal actors, informational deficits (particularly regarding scientific and statistical evidence) and cognitive biases of police investigators, witnesses (lay and expert), attorneys, judges, and jurors pose serious obstacles. We conclude by suggesting that research in judgment and …
Effect Of Two-Year Caloric Restriction On Bone Metabolism And Bone Mineral Density In Non-Obese Younger Adults: A Randomized Clinical Trial, Dt Villareal, L Fontana, Sk Das, Et Al.
Effect Of Two-Year Caloric Restriction On Bone Metabolism And Bone Mineral Density In Non-Obese Younger Adults: A Randomized Clinical Trial, Dt Villareal, L Fontana, Sk Das, Et Al.
Faculty, Staff and Students Publications
Although caloric restriction (CR) could delay biologic aging in humans, it is unclear if this would occur at the cost of significant bone loss. We evaluated the effect of prolonged CR on bone metabolism and bone mineral density (BMD) in healthy younger adults. Two-hundred eighteen non-obese (body mass index [BMI] 25.1?±?1.7?kg/m(2) ), younger (age 37.9?±?7.2 years) adults were randomly assigned to 25% CR (CR group, n?=?143) or ad libitum (AL group, n?=?75) for 2 years. Main outcomes were BMD and markers of bone turnover. Other outcomes included body composition, bone-active hormones, nutrient intake, and physical activity. Body weight (-7.5?±?0.4 versus …
Geospatial Analysis Of Food Environment Demonstrates Associations With Gestational Diabetes, Mk Kahr, Ma Suter, J Ballas, Sm Monga, W Lee, M Hu, Cd Shope, A Chesnokova, L Krannich, En Griffin, J Mastrobattista, Ga Dildy, Sl Strehlow, R Ramphul, Et Al.
Geospatial Analysis Of Food Environment Demonstrates Associations With Gestational Diabetes, Mk Kahr, Ma Suter, J Ballas, Sm Monga, W Lee, M Hu, Cd Shope, A Chesnokova, L Krannich, En Griffin, J Mastrobattista, Ga Dildy, Sl Strehlow, R Ramphul, Et Al.
Faculty, Staff and Students Publications
BACKGROUND: Gestational diabetes mellitus (GDM) is one of most common complications of pregnancy, with incidence rates varying by maternal age, race/ethnicity, obesity, parity, and family history. Given its increasing prevalence in recent decades, covariant environmental and sociodemographic factors may be additional determinants of GDM occurrence. OBJECTIVE: We hypothesized that environmental risk factors, in particular measures of the food environment, may be a diabetes contributor. We employed geospatial modeling in a populous US county to characterize the association of the relative availability of fast food restaurants and supermarkets to GDM. STUDY DESIGN: Utilizing a perinatal database with >4900 encoded antenatal and …
Emerging Pathogens In Cystic Fibrosis Patients At Virginia Commonwealth University Medical Center (Vcumc), Emily M. Hill
Emerging Pathogens In Cystic Fibrosis Patients At Virginia Commonwealth University Medical Center (Vcumc), Emily M. Hill
Theses and Dissertations
Cystic fibrosis (CF) is an autosomal recessive disorder affecting 70,000 individuals worldwide. This disease is characterized by the buildup of mucus in the airways leading to chronic lung infections resulting in pulmonary failure and death in 95% of CF patients. Routine surveillance of CF pathogens using traditional microbiology culture guides management and treatment of CF patients. Molecular profiling studies have revealed emerging pathogens that may play a role in CF lung disease by either directly causing infection or upregulating the virulence factors of classic CF pathogens, such as P. aeruginosa; however, routine CF culture protocols have not been modified …
Faculty Publications 2015, Lsu Health Sciences Center New Orleans
Faculty Publications 2015, Lsu Health Sciences Center New Orleans
Historical Faculty Publications
This Faculty bibliography contains 890 publications.
Suppressed Intuitions, Large Number Coincidences, And A Mathematical Foundation For Life And Consciousness, Maurice Goodman
Suppressed Intuitions, Large Number Coincidences, And A Mathematical Foundation For Life And Consciousness, Maurice Goodman
Articles
A brief examination of the natural sciences reveals that we are still under the influence of pre Copernican intuitions. These have only been suppresses and not supplanted. This is why we appeal to such things as large number coincidences in the hope that the mathematics, which unlike us does not suffer from naive beliefs, will lead us in the right direction. However, we need to be extremely careful as it is easy to create these coincidences and over interpret their significance. In the 1980’s work on these coincidences did lead to a mathematical formulism which seems to have relevance in …
Kinesiotaping As An Alternative Treatment Method For Carpal Tunnel Syndrome, Duygu Geler Külcü, Canan Bursali, İlknur Aktaş, Seli̇n Bozkurt Alp, Feyza Ünlü Özkan, Pinar Akpinar
Kinesiotaping As An Alternative Treatment Method For Carpal Tunnel Syndrome, Duygu Geler Külcü, Canan Bursali, İlknur Aktaş, Seli̇n Bozkurt Alp, Feyza Ünlü Özkan, Pinar Akpinar
Turkish Journal of Medical Sciences
Background/aim: Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy. Conservative treatment choices are not always satisfactory. The aim of this study was to investigate the effect of kinesiotaping (KT) on pain level, grip strength, and functional status compared with that of placebo KT and orthotic device (OD) in patients with CTS. Materials and methods: In this randomized, placebo-controlled study, participants were allocated into one of three groups: an experimental KT group (Group 1), a placebo KT group (Group 2), and an OD group (Group 3). Visual analogue scale (VAS) and Douleur Neuropathique 4 (DN4) scores, dynamometric grip strength …
Expression Of Maspin In Testis Tumors With Germ Cells Andits Relation With Angiogenesis Factors, Hüseyi̇n Çeli̇k, Tahsi̇n Turunç, Nebi̇l Bal, Eray Hasirci, Alaaddi̇n Akay, Çeti̇n Levent Peşki̇rci̇oğlu
Expression Of Maspin In Testis Tumors With Germ Cells Andits Relation With Angiogenesis Factors, Hüseyi̇n Çeli̇k, Tahsi̇n Turunç, Nebi̇l Bal, Eray Hasirci, Alaaddi̇n Akay, Çeti̇n Levent Peşki̇rci̇oğlu
Turkish Journal of Medical Sciences
Background/aim: We aimed to evaluate the importance of maspin expression in testicular tumors with germ cells, its effect on prognosis, and the relation with angiogenesis factors. Materials and methods: The paraffin blocks of the orchiectomy materials of 32 patients who had undergone orchiectomy due to testicular tumors were taken within the scope of the study. The specimens of the cases included in the study group were reexamined under light microscope. Results: While just one maspin-positive sample was found in the seminoma cases, maspin stained positively in 6 of the nonseminoma germ cell tumors (NSGCTs). No statistical difference was found between …
Effects Of Resveratrol And Cigarette Smoking Onbone Healing: Histomorphometric Evaluation, Özge Kolkesen Şahi̇n, Müge Çina Aksoy, Mustafa Ci̇hat Avunduk
Effects Of Resveratrol And Cigarette Smoking Onbone Healing: Histomorphometric Evaluation, Özge Kolkesen Şahi̇n, Müge Çina Aksoy, Mustafa Ci̇hat Avunduk
Turkish Journal of Medical Sciences
Background/aim: The aim of the present study is to investigate the effects of cigarette smoke (CS) and simultaneous application of resveratrol on bone healing histomorphometrically and to evaluate the effects of resveratrol on negative effects of CS. Materials and methods: For 4 weeks, Sprague Dawley rats were exposed to cigarette smoke at the equivalent of 6 cigarettes per day. After this period, monocortical defects were created in femurs by a trephine bur on day 28. Starting from the day of defect creation to the 28th postoperative day, rats were given 20 mg/kg body weight resveratrol. Histomorphometric examination of the number …
Hormone Therapy In Hypospadias Surgery: A Survey On The Current Practice In Turkey, Gülnur Göllü Bahadir, Ergun Ergün, Onur Telli̇, Fari̇d Khanmammadov, Ahmet Murat Çakmak
Hormone Therapy In Hypospadias Surgery: A Survey On The Current Practice In Turkey, Gülnur Göllü Bahadir, Ergun Ergün, Onur Telli̇, Fari̇d Khanmammadov, Ahmet Murat Çakmak
Turkish Journal of Medical Sciences
Background/aim: Nowadays surgical intervention is possible in smaller phalluses and younger children with hypospadias disease. Different hormone treatments with different doses, modalities, indications, and treatment times come along with some disputes. The aim of this study is to evaluate the management approaches in hypospadias surgery of surgeons in regards to hormone preparations. Materials and methods: Questionnaires were sent via e-mail to 110 actively working pediatric surgeons and urologists. The answers of 99 surgeons were evaluated (90%). Two surgeons declared that they did not perform hypospadias surgery. Results: When testosterone usage in penile surgery was questioned, 44.4% of participants (n = …
Management Of Acute Postoperative Hypertension For Reducing Cardiovascular Complications In Cancer Patients: When And How Aggressively?, Ning Lou, Daofeng Wang, Zhi Wang, Wenfeng Ye, Xiao Liu
Management Of Acute Postoperative Hypertension For Reducing Cardiovascular Complications In Cancer Patients: When And How Aggressively?, Ning Lou, Daofeng Wang, Zhi Wang, Wenfeng Ye, Xiao Liu
Turkish Journal of Medical Sciences
Background/aim: We sought to determine what factors cardiovascular complications (CVCs) correlate with in cancer patients with acute postoperative hypertension (APH) and to define when and how aggressively to treat this disorder in the present study. Materials and methods: A retrospective observational study of cancer patients with postoperative hypertension at a single intensive care unit between July 2007 and June 2013 was conducted. The outcome of interest was the incidence of a CVC. Results: There were 1162 patients enrolled, of which 92 (7.9%) experienced one or more CVCs. Preexisting hypertension (OR 38.3, 95% CI 3.2-457.4, P = 0.004) and choice of …
The Effect Of Systemic Isotretinoin Treatment On Skin Biophysicalparameters Among Patients With Acne Vulgaris, Emi̇ne Çölgeçen, Kemal Özyurt, Ayten Ferahbaş Kesi̇koğlu
The Effect Of Systemic Isotretinoin Treatment On Skin Biophysicalparameters Among Patients With Acne Vulgaris, Emi̇ne Çölgeçen, Kemal Özyurt, Ayten Ferahbaş Kesi̇koğlu
Turkish Journal of Medical Sciences
Background/aim: Systemic isotretinoin has been widely considered an effective and safe medical treatment for severe and refractory acne for nearly 3 decades. However, it also appears to cause undesirable cutaneous side effects. The aim of this study was to prospectively measure biophysical parameters of skin function among patients with acne vulgaris before and after 3 months of isotretinoin therapy, including pH, temperature, sebum content, skin hydration, and transepidermal water loss. Materials and methods: The study cohort consisted of 19 patients with acne vulgaris. Noninvasive methods were used to measure the biophysical characteristics of forehead skin. All measurements were repeated following …
A Simple Risk Score In Acute St-Elevation Myocardial Infarction: Modified Acef(Age, Creatinine, And Ejection Fraction) Score, Arzu Kalayci Karabay, Veci̇h Oduncu, Çeti̇n Geçmen, Seli̇m Topcu, Can Yücel Karabay, İbrahi̇m Akin İzgi̇, Cevat Kirma
A Simple Risk Score In Acute St-Elevation Myocardial Infarction: Modified Acef(Age, Creatinine, And Ejection Fraction) Score, Arzu Kalayci Karabay, Veci̇h Oduncu, Çeti̇n Geçmen, Seli̇m Topcu, Can Yücel Karabay, İbrahi̇m Akin İzgi̇, Cevat Kirma
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to evaluate if the modified ACEF (age, creatinine, and ejection fraction) score is a predictor of major adverse cardiac and cerebrovascular events during 1 year of follow-up in patients with ST-segment elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (PCI). Materials and methods: We retrospectively enrolled 1632 consecutive patients who were admitted to our emergency department diagnosed with STEMI within 12 h of chest pain and treated with primary PCI. The modified ACEF score, determined with a simplified scoring system, was calculated. The patients were grouped into tertiles according to this …
The Effects Of Balneotherapy On Acute, Process-Related, And Cumulative Peripheral Cardiac Responses And Pulmonary Functions In Patients With Musculoskeletal Disorders, Senem Şaş, Şeyda Toprak Çelenay, Derya Özer Kaya
The Effects Of Balneotherapy On Acute, Process-Related, And Cumulative Peripheral Cardiac Responses And Pulmonary Functions In Patients With Musculoskeletal Disorders, Senem Şaş, Şeyda Toprak Çelenay, Derya Özer Kaya
Turkish Journal of Medical Sciences
Background/aim: This study aimed to evaluate the effects of balneotherapy on acute, process-related, and cumulative peripheral cardiac responses and pulmonary functions in patients with musculoskeletal disorders. Materials and methods: Ninety-eight patients with musculoskeletal disorders referred to physiotherapy with balneotherapy were recruited. The patients received balneotherapy for 20 min 5 times per week for 2 weeks. Blood pressure and pulse were measured at the 0th, 5th, 10th, 20th, and 30th minutes during the 1st and 10th sessions. All patients were subjected to pulmonary function testing before balneotherapy and after the 10th session. Results: It was found that systolic blood pressure decreased …
Clinical Characteristics And Outcome Of Brucella Endocarditis, Na Du, Feng Wang
Clinical Characteristics And Outcome Of Brucella Endocarditis, Na Du, Feng Wang
Turkish Journal of Medical Sciences
Background/aim: Brucella endocarditis, which is a rare condition, is the most common cause of death in human brucellosis, leading to severe cardiac complications. By collecting and analyzing clinical cases, we analyzed the clinical characteristics and outcome of Brucella endocarditis in endemic areas in China. Materials and methods: Presented here are 5 cases of Brucella endocarditis, all managed uniformly. We present the clinical, serological, and echocardiographic features; the therapeutic approach; and the follow-up of five patients with Brucella endocarditis. Results: There was a predominance of aortic involvement (4 cases) and a high incidence of left ventricular failure (5 cases). Polymerase chain …