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Bone Marrow Transplantation In A Mouse Model Of Cooley’S Anemia, Jonathan Russell Lockhart Jan 2018

Bone Marrow Transplantation In A Mouse Model Of Cooley’S Anemia, Jonathan Russell Lockhart

All ETDs from UAB

β-thalassemia is a group of inherited blood disorders that result in defects in β-globin chain production. Cooley’s anemia (CA), or β-thalassemia major, is the most severe form of the disease and occurs when an individual has mutations in both copies of the adult β-globin gene. Patients with CA fail to make adult hemoglobin, have ineffective erythropoiesis, suffer from severe anemia, and are transfusion dependent for life. Currently, allogeneic bone marrow transplantation (BMT) is the only cure; however, few patients have suitable donors for this procedure that carries a significant risk of morbidity and mortality. To develop new and safer alternatives …

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The Oxidative Tyrosine Modification, O,O’-Dityrosine, In Lung Disease, Morgan Locy Jan 2018

The Oxidative Tyrosine Modification, O,O’-Dityrosine, In Lung Disease, Morgan Locy

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The oxidative tyrosine modification, o,o′-dityrosine, has been identified in various pathologic conditions associated with oxidative stress in mammalian systems, and demonstrated to be important in physiologic processes in invertebrate organisms. The formation of o,o’-dityrosine is catalyzed by a heme peroxidase (hPx) in the presence of hydrogen peroxide (H2O2). The understanding of this stable, covalent tyrosine modifica-tion in lung biology is limited. Oxidative stress has been implicated in the pathogenesis of various lung diseases, including interstitial lung disease (ILD) and cystic fibrosis (CF). We observed that the oxidative protein modification, o,o’-dityrosine, was markedly ele-vated in the circulating plasma of ILD patients …

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Aberrant Astrocyte Maturation Contributes To Rett Syndrome Pathogenesis, Natasha Lynn Pacheco Jan 2018

Aberrant Astrocyte Maturation Contributes To Rett Syndrome Pathogenesis, Natasha Lynn Pacheco

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Rett syndrome (RTT) is caused by mutations in the gene encoding the transcriptional modulator, Methyl-CpG-Binding Protein 2 (MeCP2). RTT is characterized by motor, behavioral and physiological deficits. MECP2 mutations are associated with other disorders such as autism, schizophrenia, and intellectual disability, underscoring the important role of MeCP2 for typical brain function. Much of our understanding of MeCP2 function is derived from transcriptomic studies carried out over the last 10 years with the general assumption that alterations in the transcriptome correlate with proteomic changes. Advances in mass spectrometry-based proteomics have facilitated recent interest in the examination of global protein expression. In …

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The Role Of Astrocytes In The Development Of Central Chemosensitivity, Kelsey Patterson Jan 2018

The Role Of Astrocytes In The Development Of Central Chemosensitivity, Kelsey Patterson

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In the two decades since MECP2 was identified as the causative gene in the majority of Rett Syndrome (RTT) cases, transgenic mouse models have played a critical role in our understanding of this X-linked neurodevelopmental disease. However, their exclusive use presents a limitation in translating findings from animal models to the clinic. Here, we characterized growth, anatomical, behavioral, and motor deficits in a novel zinc-finger nuclease murine RTT model from birth through adulthood. Male rats lacking the transcriptional regulatory protein, MeCP2 (Mecp2ZFN/y), are noticeably symptomatic as early as postnatal day (P) 21 and die prematurely, while females lacking one copy …

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T Cell Immunity Directed Against Novel Anti-Sense Cryptic Epitopes And Its Impact On Hiv Viral Evolution, Binghao Jason Peng Jan 2018

T Cell Immunity Directed Against Novel Anti-Sense Cryptic Epitopes And Its Impact On Hiv Viral Evolution, Binghao Jason Peng

All ETDs from UAB

After nearly four decades of scientific research, a global solution in eradicating the human immunodeficiency virus - 1 (HIV-1) pandemic has still yet to be discovered. The advent of antiretroviral therapies (ART) has significantly decreased the diseases burden for those infected with the virus; however, the access to ART is often limited to those with the financial abilities to afford it. For this reason, finding a way to vaccinate against HIV-1 successfully remains a sought-after pragmatic solution to this worldwide health issue. HIV immunological studies have taught us that increasing the breadth of response to the virus holds significant potential …

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Mucus Adhesion As A Therapeutic Target In Cystic Fibrosis, Courtney Fernandez Petty Jan 2018

Mucus Adhesion As A Therapeutic Target In Cystic Fibrosis, Courtney Fernandez Petty

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Cystic fibrosis (CF) is a genetic disease resulting from mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. CFTR is an ion channel responsible for proper movement of chloride and bicarbonate ions across the apical cell surface. Defective CFTR results in an absence of bicarbonate transport, which functions in part to chelate Ca2+, a divalent cation found in abundance in mucin granules in normal conditions; this yields a hyperviscous and adhesive mucus on the respiratory and gastrointestinal tracts of patients with CF. Bronchial mucins are glycosylated proteins with neutral and negative sugars modified by negatively charged sialic and neuraminic …

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Identification Of Molecular Regulators Of Morphogenesis During Early Development Of Xenopus, Ivan Popov Jan 2018

Identification Of Molecular Regulators Of Morphogenesis During Early Development Of Xenopus, Ivan Popov

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During embryonic development of all animal species, dramatic changes in morphology occur to transform a single-celled zygote into a well-organized adult body that contains different organs positioned in stereotypical ways for the species. The processes that shape tissues and organs are called morphogenesis, and gastrulation is the first morphogenetic process in embryogenesis. During gastrulation, three germ layers are specified and a set of regionally specific cell movements act in concert to position these germ layers for proper establishment of future body plan of the developing animal. Although factors regulating cell lineage specification have been studied extensively, the molecular machinery controlling …

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The Impact Of The Cd11b 77his And 1146ser Variants On Mac-1 Activity And Functions, Justin Timothy Avery Jan 2018

The Impact Of The Cd11b 77his And 1146ser Variants On Mac-1 Activity And Functions, Justin Timothy Avery

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Mac-1 (CD11b/CD18, ITGAM/ITGB2, CR3) is a member of the β2 integrin family. While primarily expressed on myeloid lineage cells such as monocyte/macrophages, neutrophils, and dendritic cells, Mac-1 is also found on natural killer cells and some B cells and T cell populations. Mac-1 has over 50 ligands, many of which are critical for adhesion, signaling, and the promotion of immune functions like phagocytosis. Genome-wide association studies (GWAS) have linked several SNPs in ITGAM, the gene which codes for CD11b, with the autoimmune disease systemic lupus erythematosus (SLE). rs1143679 results in an arginine to histidine change at amino acid position 77 …

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Mitochondria-To-Nucleus Retrograde Signaling And Its Role In Cancer, Trevor Carden Jan 2018

Mitochondria-To-Nucleus Retrograde Signaling And Its Role In Cancer, Trevor Carden

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Mitochondrial dysfunction is considered a hallmark of cancer. Mitochondria are essential, cellular organelles that participate in processes including energy production, calcium homeostasis and steroid metabolism. Mitochondria have been more recently appreciated for their role in cellular signaling, bringing about a greater understanding of their role in many diseases including cancer. Retrograde signaling is a mechanism by which the nucleus responds to mitochondrial dysfunction by modulating its own transcriptional programs to maintain metabolic and cellular processes. Many genes have already been identified as participants in or mediators of this signaling mechanism; these include cell signaling, metabolic and structural genes as well …

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Neuropeptide Y Cells Regulate Anxiety Behavior, Katelynn Corder Jan 2018

Neuropeptide Y Cells Regulate Anxiety Behavior, Katelynn Corder

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Dysregulation of the GABAergic system has long been implicated in anxiety disorders. Classic anxiolytic drugs, such as benzodiazepines, increase GABAergic transmission by modulating GABA¬A receptors, relieving anxiety symptoms. However, these treatments are not always effective and are often accompanied by negative side effects. Glutamate decarboxylase (GAD) is the enzyme responsible for producing GABA. Recent studies have shown that when the isoform GAD67 is reduced in specific brain regions or GABAergic subtypes, differential anxiety effects were found. These studies suggest that targeting specific GABAergic cell subtypes may provide a more effective treatment for anxiety disorders. Neuropeptide Y (NPY) is an abundant …

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The Primary Cilium Regulates Interstitial Immune Cells During Renal Cystogenesis, Cheng Song Jan 2018

The Primary Cilium Regulates Interstitial Immune Cells During Renal Cystogenesis, Cheng Song

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Renal cysts are a pathological condition that can lead to end-stage renal failure and death. The mechanisms that underlie renal cyst development are under active investigation, and emerging evidence has revealed defects in a number of proteins required for cilia assembly or signaling, such as intraflagellar transport (IFT) proteins and the polycystins. Characterization of mice harboring conditional IFT mutations suggests that the rate of cyst formation is dependent upon the timing of cilia loss. Induction of cilia loss in juvenile mice results in rapid cyst development, while induction of cilia loss in adult mice leads to a slower progressing form …

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The Role Of Pim Kinases In Hepatoblastoma Tumorigenicity, Stem Cell-Like Cancer Cell Maintenance, And Chemoresistance, Laura Lee Stafman Jan 2018

The Role Of Pim Kinases In Hepatoblastoma Tumorigenicity, Stem Cell-Like Cancer Cell Maintenance, And Chemoresistance, Laura Lee Stafman

All ETDs from UAB

Hepatoblastoma is the most common primary liver malignancy in children. Despite increasing incidence, treatment has not changed significantly in the past 20 years, making the need for novel therapeutics imperative. Proviral Integration site for Moloney murine leukemia virus (PIM) kinases are a family of serine/threonine kinases that have been implicated in multiple other cancer types including the adult liver cancer, hepatocellular carcinoma. Emerging evidence has begun to elucidate a role for PIM kinases in stem-cell like cancer cells (SCLCCs). This subpopulation of cells is thought tobe responsible for tumor maintenance, recurrence, metastasis, and chemoresistance. Chemoresistance is a significant barrier to …

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Protein O-Glcnacylation In Hippocampal Hyperexcitability & Gabaergic Neurotransmission, Luke Thomas Stewart Jan 2018

Protein O-Glcnacylation In Hippocampal Hyperexcitability & Gabaergic Neurotransmission, Luke Thomas Stewart

All ETDs from UAB

Plasticity at central synapses is a vital component of neuronal function and an intensively studied phenomenon thought to underlie learning and memory processes in brain structures including the hippocampus and cerebral cortex. A principle mechanism at work during long-term plasticity is the rapid and heavily regulated post-translational modification of synaptic proteins such as phosphorylation and ubiquitination. A comparatively understudied modification is ‘O-GlcNAcylation’, a distinct form of monoglycosylation with rapid intracellular signaling capacity as opposed to the structural and extracellular signaling roles of O- and N-linked polysaccharide chains on conventionally glycosylated proteins. O-GlcNAcylated proteins are found in every cell type/tissue system …

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Pharmacological Inhibition Of Thioredoxin-Interacting Protein To Protect Against Diabetes, Lance Thielen Jan 2018

Pharmacological Inhibition Of Thioredoxin-Interacting Protein To Protect Against Diabetes, Lance Thielen

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The loss of functional beta cell mass represents a major factor in the pathogenesis of type 1 and type 2 diabetes. Inadequate production of insulin, a glucose-lowering hormone, and elevated glucagon production, a gluconeogenic hormone, contribute to impaired glycemic control and hyperglycemia. This promotes a vicious cycle involving glucotoxicity and additional beta cell dysfunction. Currently there are no therapies that halt this process; however, thioredoxin-interacting protein (TXNIP) has recently emerged as a promising therapeutic target. TXNIP was found to be the top glucose-induced gene in a human pancreatic islet microarray, is increased in mouse models of diabetes and diabetic human …

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The Effect Of Allergic Airway Sensitization On The Immune Response To Pulmonary Bacterial Infection., Arthur Harold Totten Jan 2018

The Effect Of Allergic Airway Sensitization On The Immune Response To Pulmonary Bacterial Infection., Arthur Harold Totten

All ETDs from UAB

Asthma is a chronic respiratory disease associated with small airway obstruction and hy-perreactivity. Greater than 300 million people are estimated to live with asthma world-wide, and in the United States (US), estimated cost-of-care is over $50 billion per year. Allergic sensitization and infections have proven to be important in both asthmatic development, as well as recurrent exacerbations. Diversity and number of bacterial species are increased in asthmatics compared to non-asthmatics, and is also predictive of increased incidence of res-piratory infections. Mycoplasma pneumoniae (Mpn) is an atypical bacterial pathogen of the class Mollicutes, which lacks a cell wall and is an …

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Analysis Of The Gtp Cyclohydrolase I/Tetrahydrobiopterin Pathway In Glioblastoma Biology, Anh Tran Jan 2018

Analysis Of The Gtp Cyclohydrolase I/Tetrahydrobiopterin Pathway In Glioblastoma Biology, Anh Tran

All ETDs from UAB

Glioblastomas (GBMs) are the most common primary malignant brain tumors in adults and one of the most aggressive cancers with high rates of recurrence and therapeutic resistance. In GBMs, subpopulations of highly tumorigenic cells called brain tumor initiating cells (BTICs) have the unique capacity to promote tumor maintenance, therapeutic resistance, and angiogenesis. Depending on the level, differentiation state, and tumor stage, reactive nitrogen and oxygen species inhibit or increase cancer growth and BTIC maintenance. GTP cyclohydrolase 1 (GCH1) is the rate limiting enzyme in a pathway that can regulate reactive species production but has not been thoroughly investigated in GBM. …

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Novel Insights Into Neurofibromin Function And Human Neurofibromatosis Type 1 Mutations Using Genetically Engineered Mouse Models, Ashley Nicole Turner Jan 2018

Novel Insights Into Neurofibromin Function And Human Neurofibromatosis Type 1 Mutations Using Genetically Engineered Mouse Models, Ashley Nicole Turner

All ETDs from UAB

Loss of NF1 in different developmental and cellular contexts leads to unique physiological outcomes due to loss of neurofibromin function, including embryonic lethality, sporadic cancers, and the genetic disorder NF1. Neurofibromin acts as a tumor suppressor by modulation of RAS signaling, with other functions of this multi-domain protein being less clear. Even within the monogenic disorder of NF1, the clinical heterogeneity and mutational spectrum are immense, revealing the complexity underlying this disorder. There is a huge urgency and need for NF1 therapeutic treatments, and the same urgency to develop in vivo models to better understand NF1 that can be utilized …

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Synaptic Mechanisms Underlying The Integration Of Adult-Generated Neurons In The Dentate Gyrus, Ryan Vaden Jan 2018

Synaptic Mechanisms Underlying The Integration Of Adult-Generated Neurons In The Dentate Gyrus, Ryan Vaden

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The dentate gyrus is a region in the adult brain where new neurons continue to be generated throughout life. While most adult-generated neurons undergo apoptosis within the first few weeks of maturation, a fraction survives and integrates into the existing circuit. It is well established that γ-aminobutyric acid (GABA) receptor-mediated mechanisms contribute to the activity-dependent regulation of adult-neurogenesis. GABAergic interneurons regulate stem cell quiescence, progenitor proliferation, and the synaptic integration of newborn neurons, however the synaptic interactions underlying integration are not fully understood. Furthermore, the impact of adult-generated neurons integrating into the existing circuit is not completely known. The collective …

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Nf-Κb And Methyl-Lysine Signaling In The Epigenetic Regulation Of Memory, William Mitchell Webb Jan 2018

Nf-Κb And Methyl-Lysine Signaling In The Epigenetic Regulation Of Memory, William Mitchell Webb

All ETDs from UAB

Epigenetic mechanisms such as DNA methylation and histone methylation are critical regulators of gene transcription during memory consolidation and retrieval. However, the means by which these mechanisms are themselves initiated and directed to specific gene regions, and the extent to which these marks coordinate control of gene expression, remain poorly understood. In this dissertation, we explore the role of methyl-lysine signaling in the epigenetic regulation of gene expression in two contexts. First, we investigated the role of histone H3 lysine 4 tri-methylation (H3K4me3) and DNA 5-hydroxymethylation (5hmC) during memory retrieval, finding that these marks increased globally and at CpG-enriched coding …

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Mechanisms Of Leucine-Rich Repeat Kinase 2 And Alphα-Synuclein In Pathogenesis Of Parkinson Disease, Hisham Abdelmotilib Jan 2018

Mechanisms Of Leucine-Rich Repeat Kinase 2 And Alphα-Synuclein In Pathogenesis Of Parkinson Disease, Hisham Abdelmotilib

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Two pathological hallmarks define Parkinson disease (PD) including dopaminergic neurodegeneration in substantia nigra pars compacta (SNpc) and accumulation of α-synuclein insoluble inclusions, called Lewy pathology, in surviving neurons. LRRK2 (encoding Leucine-rich repeat kinase 2) and SNCA (encoding α-synuclein (α-syn)) are two major genes linked to PD. Pathogenic mutations in these two genes cause autosomal dominant (AD) PD. Additionally, genetic variations in LRRK2 and SNCA are associated with increased risk of sporadic PD. Cellular and animal studies using preformed α-syn fibrils (PFF) demonstrate that the fibrils can be internalized by neurons and act as seeds that can recruit and corrupt endogenously …

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Collecting Duct Nos1 Activation Is Necessary For Increased Glomerular Filtration Rate In Response To A High Salt Diet, John Miller Allan Jan 2018

Collecting Duct Nos1 Activation Is Necessary For Increased Glomerular Filtration Rate In Response To A High Salt Diet, John Miller Allan

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We previously reported that nitric oxide synthase-1 (NOS1) in the collecting duct (CD) is critical for maintaining fluid-electrolyte balance during high salt diet. Lack of NOS1 in the CD (CDNOS1KO) results in reduced sodium excretion, urine output, and urinary nitrite/nitrate excretion compared to male control mice after 1 day of a high salt diet (4% NaCl). By day 7 of a high salt diet, CDNOS1KO mice display significantly increased systolic blood pressure with sodium excretion returning to levels similar to control mice. Sex differences in renal sodium handling are important to consider. Female rodents possess redundant mechanisms for sodium handling …

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Applications Of Next-Generation Sequencing And Functional Genomics In Translational Medicine, Andrew Hardigan Jan 2018

Applications Of Next-Generation Sequencing And Functional Genomics In Translational Medicine, Andrew Hardigan

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The development of next-generation sequencing (NGS) technologies has led to unparalleled advances in our understanding of the genetic basis of disease, evolution, and genetic and genomic regulation. Building on the advances made in the Human Genome Project and more recent efforts such as the Encylopedia of DNA Elements (ENCODE) and the Roadmap Epigenomics Project, whole-genome and whole-exome sequencing (WGS/WES) and a wide variety of NGS-enabled functional assays are bridging the gap between scientific discovery and clinical medicine. This trend towards genomically informed “bench-to-bedside” translational medicine is driven in large part by the sharply decreasing costs for NGS in both clinical …

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Effects Of Novel Inhibitors Against Wnt/Β-Catenin Signaling In Ovarian And Triple-Negative Breast Cancers, Abhishek Gangrade Jan 2018

Effects Of Novel Inhibitors Against Wnt/Β-Catenin Signaling In Ovarian And Triple-Negative Breast Cancers, Abhishek Gangrade

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Ovarian and triple-negative breast cancers (TNBC) are aggressive due to their dependence on Wnt/β-catenin signaling. Niclosamide, a strong inhibitor of Wnt/β-catenin signaling, is an efficacious cytotoxic agent for various cancers in vitro, including ovarian and breast cancers. However, it has cross-reactivity with mTOR, STAT3, and Notch pathways. A limitation of using the agent in animal studies involves its poor water solubility and bioavailability. This study investigates novel compounds based on the structure of niclosamide to improve specificity for the Wnt/β-catenin signaling pathway. The investigation evaluates three questions: 1) whether WNT974 inhibits Wnt/β-catenin signaling in ovarian cancer; 2) whether novel analogs …

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The Effect Of Mitochondrial-Derived Ros On Calcium Handling And Cardiac Function In Heart, Kah Yong Goh Jan 2018

The Effect Of Mitochondrial-Derived Ros On Calcium Handling And Cardiac Function In Heart, Kah Yong Goh

All ETDs from UAB

Mitochondria are abundantly present in metabolic active organs such as the heart. The presence of mitochondria are crucial to provide energy in the form of ATP, regulate calcium handling, facilitate cell fate, and are involved in metabolic modulation. In the process of generating ATP through oxidative phosphorylation, mitochondria produce reactive oxygen species (ROS) as a side product. In the heart, mitochondria is a major source of ROS. Under normal conditions, ROS are kept at a physiologically relevant and healthy level. Unfortunately, excessive ROS levels during pathological states, such as pressure overload heart failure, appears as a threat to the whole …

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Risk Factors Associated With Multiple Myeloma, Stephen Gragg Jan 2018

Risk Factors Associated With Multiple Myeloma, Stephen Gragg

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Multiple myeloma (MM) is a hematologic malignancy in which clonal plasma cells accumulate in the bone marrow, leading to the formation of lytic bone lesions, hypercalcemia, anemia, renal insufficiency, and immunosuppression. It develops from a pre-malignant condition known as monoclonal gammopathy of undetermined significance (MGUS), which is prevalent in up to 3% of White populations over the age of 50 years, and twice that in Black populations. Although much progress has been made toward understanding the large scale genomic aberrations that facilitate the formation of MGUS clones and the various copy-number variations and mutations that trigger the development of MM, …

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The Contribution Of Mitochondrial Genetic Background To Glucose Metabolism And Insulin Sensitivity In Vivo, Melissa June Sammy Jan 2018

The Contribution Of Mitochondrial Genetic Background To Glucose Metabolism And Insulin Sensitivity In Vivo, Melissa June Sammy

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It has been observed that the risk of developing diabetes increases with age as well as among certain races, most notably African Americans and Hispanic Americans who are almost two times as likely to develop perturbed glucose metabolism compared to Caucasian Americans. Interestingly, there are distinct mitochondrial DNA polymorphisms that distinguish people of different races and thus may contribute to differential susceptibility to diseases of glucose metabolism. To test the hypothesis that the mitochondrial DNA (mtDNA) contributes to glucose metabolism and insulin sensitivity, two strains of mice were used with distinct mtDNA sequences namely, C57BL6/J and C3H/HeN as well as …

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Epigenetic Regulation Of Stem Cell Fate Determination And Tumorigenesis, Kushani Shah Jan 2018

Epigenetic Regulation Of Stem Cell Fate Determination And Tumorigenesis, Kushani Shah

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It is unclear how H3K4 methylation, an epigenetic modification associated with gene activation, regulates stem cell fate determination and tumorigenesis. DPY30 is one of the core subunits of the SET1/MLL complex in mammals responsible for H3K4me. DPY30 enhances the H3K4me activity of the SET1/MLL complex. Here, I sought to define role of DPY30 and H3K4me3 in postnatal neurogenesis and hematopoietic malignancies. Using a conditional knockout model, I found that Dpy30 deficiency halts the development of postnatal hippocampus, the subventricular zone, and cerebellum. Deficiency in cerebellum is most likely the cause of uncoordinated ataxia-like movements in these mice. By deleting Dpy30 …

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Regulation Of Effector Cd4 T Cell Pathogenicity During Chronic Inflammation, Boyoung Shin Jan 2018

Regulation Of Effector Cd4 T Cell Pathogenicity During Chronic Inflammation, Boyoung Shin

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Effector CD4 T cells are essential for the balance between pro- and anti-inflammatory immune responses during homeostasis. Dysregulation of effector CD4 T cell responses results in chronic inflammatory disorders such as Inflammatory Bowel Disease (IBD) and Multiple Sclerosis (MS), however therapeutic options for these diseases are limited. Understanding the mechanisms that regulate pathogenicity of effector CD4 T cells is critical to devise new therapeutic interventions. Herein we show two different mechanisms that profoundly impact pathogenic potential of CD4 T cells by regulating heterogeneities of effector functions and differentiation states. Different subsets of effector CD4 T cells utilize distinct metabolic pathways. …

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Pathological Changes In Hippocampal Synaptic Transmission And Neuronal Function During Early Disease In The Novel Tgf344-Ad Rat Model, Lindsey Allyson Smith Jan 2018

Pathological Changes In Hippocampal Synaptic Transmission And Neuronal Function During Early Disease In The Novel Tgf344-Ad Rat Model, Lindsey Allyson Smith

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Alzheimer’s disease (AD) is the leading cause of dementia in those 65 years and older and the 6th leading cause of death in the United Sates. Current treatments only target symptoms of the disease and cannot slow or halt disease progression. The novel and comprehensive TgF344-AD rodent model may bridge the translational gap previous animal models have failed to traverse by providing the platform to probe pre-lesion synapse dysfunction, which is thought to result primarily from increased levels of toxic soluble amyloid beta and hyperphosphorylated tau. The most recently developed model, the TgF344-AD rat was created in 2013 by insertion …

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Multi-Antigen-Chemiluminescent-Elisa For The Diagnosis Of Trypanosoma Cruzi Infection In Chihuahua, Mexico., Jose Andrei Orozco Jan 2018

Multi-Antigen-Chemiluminescent-Elisa For The Diagnosis Of Trypanosoma Cruzi Infection In Chihuahua, Mexico., Jose Andrei Orozco

Open Access Theses & Dissertations

No abstract provided.

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