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I Think, Therefore I Can: Self-Efficacy, Self-Regulation, And Sense Of Belonging In Introductory Physics, Danielle Christine Maldonado Jan 2026

I Think, Therefore I Can: Self-Efficacy, Self-Regulation, And Sense Of Belonging In Introductory Physics, Danielle Christine Maldonado

Graduate Theses, Dissertations, and Problem Reports (ETD)

Cognitive and affective beliefs in physics classrooms are important indicators of student success beyond traditional measurements of academic performance. This body of work explores major beliefs and processes, including self-efficacy, self-regulation, and sense of belonging, as they relate to academic achievement among introductory undergraduate physics students. First, this dissertation explores the development of physics self-efficacy and physics sense of belonging, two highly correlated variables. This work identifies unique sources of physics self-efficacy and sense of belonging development from current and prior academic experiences, personality factors, and demographic variables. Then, relationships between early- semester self-efficacy and sense of belonging, mid-semester …


Dataless Neural Networks For Boolean Satisfiability And Network Optimization, Andrew Evan Gautier Jan 2026

Dataless Neural Networks For Boolean Satisfiability And Network Optimization, Andrew Evan Gautier

Graduate Theses, Dissertations, and Problem Reports (ETD)

Combinatorial optimization problems (COPs) require searching over a finite solution space subject to constraints, with the goal of satisfying an objective function. They arise in operations research, scheduling, resource allocation, circuit design, and many other fields. Many problems in combinatorial optimization (including satisfiability and network design) are NP-hard. Traditionally, researchers have built approximate solvers that return near- optimal solutions efficiently by developing increasingly sophisticated heuristics and meta- heuristics. Deep learning has provided new opportunities for improving combinatorial solvers by leveraging neural guidance to prune the search space. Traditional neural networks have distinct drawbacks in this context: separate training and …


Adaptive Multi-Grade Deep Learning For Highly Oscillatory Fredholm Integral Equations Of The Second Kind, Jie Jiang, Yuesheng Xu Jan 2026

Adaptive Multi-Grade Deep Learning For Highly Oscillatory Fredholm Integral Equations Of The Second Kind, Jie Jiang, Yuesheng Xu

Mathematics & Statistics Faculty Publications

This paper studies the use of Multi-Grade Deep Learning (MGDL) for solving highly oscillatory Fredholm integral equations of the second kind. We provide rigorous error analyses of continuous and discrete MGDL models, showing that the discrete model retains the convergence and stability of its continuous counterpart under sufficiently small quadrature error. We identify the DNN training error as the primary source of approximation error, motivating a novel adaptive MGDL algorithm that selects the network grade based on training performance. Numerical experiments with highly oscillatory (including wavenumber 500) and singular solutions confirm the accuracy, effectiveness and robustness of the proposed approach.


A New Functional Setting For Term Structure Modeling Using The Health-Jarrow-Morton Framework, Michael Pokojovy, Ebenezer Nkum, Thomas M. Fullerton Jr. Jan 2026

A New Functional Setting For Term Structure Modeling Using The Health-Jarrow-Morton Framework, Michael Pokojovy, Ebenezer Nkum, Thomas M. Fullerton Jr.

Mathematics & Statistics Faculty Publications

The well-known Heath–Jarrow–Morton (HJM) framework provides a universal and efficacious instrument for modeling the stochastic evolution of an entire yield curve by explaining the interest rate dynamics in continuous time under no-arbitrage conditions. Existing implementations involve exponentially weighted function spaces as theoretical settings for the former stochastic evolution. While the choice of weight can have a drastic effect on model calibration and subsequent forecasting, it cannot be estimated from market data and does not allow for any objective interpretation. The proposed approach does not have this shortcoming as it adopts a suitably designed unweighted function space. The HJM equation is …


Toward Completeness Theorem For Guarded Kleene Algebra With Tests, Hung Pham Jan 2026

Toward Completeness Theorem For Guarded Kleene Algebra With Tests, Hung Pham

Honors Theses

Code refactoring is a fundamental practice in software engineering, in which a program is restructured without changing the actions it performs and the results it produces. To carry out refactoring with confidence, one requires a formal method for verifying that two programs are equivalent. Guarded Kleene Algebra with Tests (GKAT) provides such a framework, an algebraic system designed to reason about a natural class of programs, namely those in which every branch and loop is governed by a Boolean condition, such as if–else and while statements. Central to GKAT is a finite set of algebraic axioms for deriving program equivalences. …


Meshless Collocation Methods For Time-Dependent Nonlocal Problems Based On Radial Basis Functions, Qiao Zhuang, Yanzhi Zhang, Zhongqiang Zhang Jan 2026

Meshless Collocation Methods For Time-Dependent Nonlocal Problems Based On Radial Basis Functions, Qiao Zhuang, Yanzhi Zhang, Zhongqiang Zhang

Mathematics and Statistics Faculty Research & Creative Works

We present radial basis function (RBF) collocation methods for time-dependent space fractional problems on general bounded domains. Building on a recently developed approach for accurately computing the integral fractional Laplacian of any RBF, we design collocation schemes for fractional heat and Stokes equations using extended-domain techniques. In particular, we propose a numerical Leray projection method for fractional Stokes problems, where both the discrete projection operator and the collocation scheme are formulated on extended domains to handle complex domains. Numerical results demonstrate the effectiveness of the proposed methods in solving time-dependent nonlocal problems on complex domains.


Identifying Relevant Covariates In Rna-Seq Analysis By Pseudo-Variable Augmentation, Yet Nguyen, Dan Nettleton Jan 2026

Identifying Relevant Covariates In Rna-Seq Analysis By Pseudo-Variable Augmentation, Yet Nguyen, Dan Nettleton

Mathematics & Statistics Faculty Publications

RNA-sequencing (RNA-seq) technology allows for the identification of differentially expressed genes, which are genes whose mean transcript abundance levels vary across conditions. In practice, RNA-seq datasets often include covariates that are of primary interest in addition to a set of covariates that are subject to selection. Some of these covariates may be relevant to gene expression levels, while others may be irrelevant. Ignoring relevant covariates or attempting to adjust for the effect of irrelevant covariates can compromise the identification of differentially expressed genes. To address this issue, we propose a variable selection method that uses pseudo-variables to control the expected …


A Composite Narxnn Approach To Photovoltaic Power Forecasting With Integrated Weather Inputs And Uncertainty Quantification, Denisse Urenda Castañeda, Sharmin Abdullah, Jackson Morgan, Honglun Xu, Michael Pokojovy, Tzu-Liang Tseng Jan 2026

A Composite Narxnn Approach To Photovoltaic Power Forecasting With Integrated Weather Inputs And Uncertainty Quantification, Denisse Urenda Castañeda, Sharmin Abdullah, Jackson Morgan, Honglun Xu, Michael Pokojovy, Tzu-Liang Tseng

Mathematics & Statistics Faculty Publications

Solar photovoltaics (PV) are a major source of sustainable energy. Yet, their power output is highly sensitive to environmental variability, particularly solar irradiance, cloud cover, wind, and temperature. Accurate forecasting of PV power is essential for efficient grid integration and energy planning, especially in applications requiring reliable longer-term forecasting rather than one-step-ahead predictions. This study presents a PV power forecasting approach using Nonlinear Autoregressive models with Exogenous Inputs (NARX), integrating large-scale numerical weather historical data as exogenous variables. Although NARX models effectively capture temporal dependencies, they can become overly dependent on historical power values, reducing responsiveness to real-time weather changes. …


Shrinking Attachment Spaces, Anastasia M. Clements Jan 2026

Shrinking Attachment Spaces, Anastasia M. Clements

West Chester University Graduate Theses, Dissertations, and Final Projects

Gluing constructions such as pushouts and other colimits are often used to attach spaces to- gether in algebraic topology. The weak topology is a natural choice of topology for attachment spaces in the context of CW-complexes and simplicial complexes because of its universal property but is insufficient for gluing together infinitely many spaces and preserving topological properties like compactness or metrizability. In this thesis, we introduce a modification of the weak topology called the shrinking attachment topology, which is defined on a space Y constructed by attaching an infinite sequence of spaces B1, B1, B3 …


Prime Numbers And Rsa Encryption In Cryptology, Burak Safaker Jan 2026

Prime Numbers And Rsa Encryption In Cryptology, Burak Safaker

A with Honors Projects

This project centers on developing an encryption and decryption system using the RSA (Rivest-Shamir-Adleman) cryptographic algorithm, which is based on the mathematical properties of prime numbers.


From Wikipedia Tables To Public Data Visualizations, Tanvir Prince Jan 2026

From Wikipedia Tables To Public Data Visualizations, Tanvir Prince

Open Educational Resources

This open educational resource presents a practical mathematics lesson in which students turn numerical data from Wikipedia into a clear data visualization. Students select a Wikipedia page with a data table but little or no visual representation. They examine the original source, date, units, definitions, and possible data limits. They then organize the data in Microsoft Excel or another spreadsheet, choose an appropriate chart, and explain what the visualization helps readers understand. A complete worked example uses the 2017 population growth rates of South American countries.

The resource package includes an instructor lesson plan, a student project guide, a Wikimedia …


Fourier Pseudospectral Methods For The Variable-Order Space Fractional Wave Equations, Yanzhi Zhang, Xiaofei Zhao, Shiping Zhou Jan 2026

Fourier Pseudospectral Methods For The Variable-Order Space Fractional Wave Equations, Yanzhi Zhang, Xiaofei Zhao, Shiping Zhou

Mathematics and Statistics Faculty Research & Creative Works

In this paper, we propose Fourier pseudospectral methods to solve the variable-order space fractional wave equation and develop an accelerated matrix-free approach for its effective implementation. In constant-order cases, fast algorithms can be designed via the fast Fourier transforms (FFTs), and the computational cost at each time step is O(Nlog⁡N) with N the total number of spatial points. In variable-order cases, however, the spatial dependence in the power s(x) leads to the failure of inverse FFTs. While the direct matrix-vector multiplication approach becomes impractical due to excessive memory requirements. Hence, we propose an accelerated matrix-free approach for effective implementation in …


Modeling The Vibration Of The Steel Tongue Drum, Rj Chandler Jan 2026

Modeling The Vibration Of The Steel Tongue Drum, Rj Chandler

Theses, Dissertations and Culminating Projects

In this paper, I plan to analyze the tones and frequencies of a steel tongue drum. I will be modeling the vibration and expected frequency of each tongue of the drum based on the solutions to the plate equation with the following boundary conditions: One fixed edge and three free edges. The fundamental frequencies are recognized as the first mode of longitudinal vibration in combination with the zeroth mode of transverse vibration of a rectangular steel plate clamped at one end. Then the first and second harmonics, which correspond to the first and second overtones respectively, are associated with higher …


Comparative Machine Learning Models For Disease Risk Prediction, Mercy Mawusi Agbley Jan 2026

Comparative Machine Learning Models For Disease Risk Prediction, Mercy Mawusi Agbley

Theses, Dissertations and Capstones

Accurate prediction of disease outcomes is crucial for improving clinical decision-making and enabling early intervention. This study compares the performance of various statistical and machine learning models for clinical risk prediction using two healthcare datasets: diabetic retinopathy and heart disease. The models assessed include Logistic Regression, LASSO, k-Nearest Neighbors (KNN), Support Vector Machines (SVM), Neural Networks, Random Forests, Gradient Boosting Machines (GBM), and a stacked ensemble model. Prior to modeling, datasets were split into train and test sets. Standardization was applied to numeric features whilst categorical features were one-hot encoded. These transformations were later applied to the test set. Principal …


Steiner Coset Partitions For Five Mutually Commuting Subgroups, Fusun Akman, Papa Sissokho Jan 2026

Steiner Coset Partitions For Five Mutually Commuting Subgroups, Fusun Akman, Papa Sissokho

Faculty Publications – Mathematics

A Steiner coset partition of a group G with respect to pairwise distinct subgroups H1 , …, Hr is a collection of pairwise disjoint cosets g1 H1 , …, gr Hr whose union is G. Motivated by the Herzog–Schönheim Conjecture, we have recently started exploring the groups that admit Steiner coset partitions. In previous work, we completely classified such groups for up to r = 4 mutually commuting subgroups. In this paper, we extend the classification to r = 5 mutually commuting subgroups.


Partially Penalized Anisotropic Trilinear Ife-Pic Methods For Dc Plasma Transport Problems, Jiahui Li, Guangqing Xia, Yajie Han, Ziping Wang, Chang Lu, Xiaoming He Jan 2026

Partially Penalized Anisotropic Trilinear Ife-Pic Methods For Dc Plasma Transport Problems, Jiahui Li, Guangqing Xia, Yajie Han, Ziping Wang, Chang Lu, Xiaoming He

Mathematics and Statistics Faculty Research & Creative Works

Implicit and hybrid particle-in-cell methods are widely used for efficient simulation of DC discharge plasma transport. However, their computations require solving anisotropic elliptic equations and face challenges related to mesh geometry, non-axisymmetry, and complex interfaces. Moreover, the accuracy of particle trajectories is critical for plasma etching and erosion studies, where errors near interfaces can significantly impact simulation results. To address these challenges, this paper proposes a three-dimensional anisotropic trilinear partially penalized immersed finite element (ATPPIFE) method, which captures interfaces on Cartesian meshes and effectively reduces discontinuities at interface element faces, ensuring that particle trajectories better align with real-world behavior. Building …


An Association Test For Ordinal Outcomes In Clustered Data With Informative Cluster Size, Hasika K. Wickrama Senevirathne, Sandipan Dutta Jan 2026

An Association Test For Ordinal Outcomes In Clustered Data With Informative Cluster Size, Hasika K. Wickrama Senevirathne, Sandipan Dutta

Mathematics & Statistics Faculty Publications

In cluster-correlated data, the number of observations in a cluster can be associated with the outcome from that cluster. This phenomenon is known as informative cluster size which can occur in cluster-randomized clinical trial data. Several studies have found that ignoring the issue of informative cluster size can produce biased results in the analysis of clustered data. Most of the existing methods for addressing informative cluster size are suited to continuous outcomes. However, ordinal outcomes and covariates are often encountered in clustered data obtained from large clinical studies. The existing methods for ordinal association testing in clustered data can produce …


Logistic-T Multinomial Mixture Model For Clustering For Microbiome Data, Wenshu Dai, Yuan Fang, Sanjeena Subedi Jan 2026

Logistic-T Multinomial Mixture Model For Clustering For Microbiome Data, Wenshu Dai, Yuan Fang, Sanjeena Subedi

Mathematics & Statistics Faculty Publications

The logistic-normal multinomial distribution has been used for modelling microbiome data obtained from high-throughput sequencing technologies, which are compositional in nature. A logistic-normal multinomial distribution is a hierarchical multinomial distribution that assumes the latent variable which are the additive log-ratio (ALR) transformed proportions in a multinomial distribution follows a Gaussian distribution. Model-based clustering algorithms have also been developed for clustering microbiome data based on the logistic-normal models. However, the Gaussian assumption may violated when the ALR transformed variable exhibit heavy-tailed distributions or has outliers. Our study introduces a novel mixture of logistic-t multinomial models that effectively address these challenges. Utilizing …


Learning Without Training, Ryan O'Dowd Jan 2026

Learning Without Training, Ryan O'Dowd

CGU Theses & Dissertations

We live in an era of big data. Whether it be algorithms designed to help corporations efficiently allocate the use of their resources, systems to block or intercept transmissions in times of war, or the helpful pocket companion known as ChatGPT, machine learning is at the heart of managing the real-world problems associated with massive data. With the success of neural networks on such large-scale problems, more research in machine learning is being conducted now than ever before. This dissertation focuses on three different projects rooted in mathematical theory for machine learning applications. Common themes throughout involve the synthesis of …


On The Influence Of Faraday Waves On Transport In Resonant Acoustic Mixing, Preston David Silverstein Jan 2026

On The Influence Of Faraday Waves On Transport In Resonant Acoustic Mixing, Preston David Silverstein

CGU Theses & Dissertations

Resonant acoustic mixing (RAM) uses low frequency high acceleration oscillatory forcing to combine fluids, particles, and powders. Although progress has been in adjacent RAM fields, there are still gaps in understanding how Faraday surface instabilities affect momentum transport to the bulk fluid and particles therein. This work investigates the energy pathways that an oscillatory mixer has and connects surface deformation to bulk rotational flow and particle forcing. This study is conducted in three phases. In phase 1, a thermodynamic first- and second-law analysis couples the surface features with the scale of subsurface rotational features. Experimental surface measurements showed that for …


Asymptotics Of Discrete Convolution Powers And Applications To Difference Schemes, Pedro Henrique Alves Silva Dos Santos Jan 2026

Asymptotics Of Discrete Convolution Powers And Applications To Difference Schemes, Pedro Henrique Alves Silva Dos Santos

Honors Theses

In this thesis we provide Gaussian Estimates and Local Limit Theorems describing the asymptotic behavior of convolution powers of a class of complex-valued functions on $\mathbb{Z}^d$. Convolution powers arise naturally in the study of partial differential equations, as well as in random walks in probability theory. In particular, they are connected to the stability theory of difference schemes used to approximate solutions to partial differential equations. We take inspiration from the work of Vidar Thomée on stability theory to restrict our attention to convolution powers of functions whose Fourier Transforms satisfy certain local expansions. We then combine the Cauchy Integral …


Enumerating Matrices Of A Given Order Over Finite Fields, Thor Richard Gabrielsen Jan 2026

Enumerating Matrices Of A Given Order Over Finite Fields, Thor Richard Gabrielsen

Honors Theses

This thesis derives a generating function that describes the matrices of a given multiplicative order over finite fields of a given order assuming that the order of a field is not a divisor of the desired order of the matrix. This is done by using the power series known as the cycle index derived from the rational canonical form. This index can be factored, and using the fact that the minimal polynomial divides some polynomial of the form x^k − 1 we can show that the minimal polynomial is squarefree. This sufficiently restricts the form of the rational canonical form …


Designing An Approach To Developing Students' Symbol Sense For The Derivative In Calculus, Laura E. Weinstein Jan 2026

Designing An Approach To Developing Students' Symbol Sense For The Derivative In Calculus, Laura E. Weinstein

Theses, Dissertations and Culminating Projects

Students often struggle to connect the conceptual meaning of the derivative with the symbolic structures of Leibniz (dy/dx) notation. Although symbol sense has been described as the coordination of mathematical concepts, signs, and objects, little is known about how instruction can purposefully support students in developing symbol sense for the derivative. This study addresses this gap by designing and examining a learning approach aimed at helping students construct the relational structures underlying derivative notation. Using design research methodology, the study engaged intact algebra, precalculus and calculus classes in a suburban New Jersey high school across iterative cycles of design, implementation, …


Mathematics And Political Ideology: A Historical Argument Against The Cultural Understanding Of Mathematics As An Apolitical Field, And A Journalistic Report On The Impact Of The Trump Administration On American Mathematics In 2026, Philo Judson Jan 2026

Mathematics And Political Ideology: A Historical Argument Against The Cultural Understanding Of Mathematics As An Apolitical Field, And A Journalistic Report On The Impact Of The Trump Administration On American Mathematics In 2026, Philo Judson

Pitzer Senior Theses

The interplay between political ideology and mathematics is a recurring theme throughout the history of the academic field. Mathematics has been used as a tool of empire, while mathematicians have been elevated by states as symbols of national genius for political prestige. Political ideologies have also shaped the field from within, both through the suppression of mathematical thought and the enforcement of mathematical authority. Since 2025, the Trump administration has launched large-scale political attacks on American institutions of higher education, which include lawsuits, discrimination investigations, and the removal of federal funding from certain institutions that don’t adhere to the administration’s …


An Introduction To Modern Conversations On Knot Invariants, Stella Shah Jan 2026

An Introduction To Modern Conversations On Knot Invariants, Stella Shah

Scripps Senior Theses

Knot Theory is a vast and diverse subfield of modern mathematics involving the classification and abstraction of knots and links. In this thesis, we wish to provide the necessary background for and an explanation of two papers in different subfields of knot theory, The Forbidden Quiver of a Link, and Biquandle Fares and Link Invariants.

In Chapter I, we begin with an introduction to knot theory and knot invariants. We continue to present the example of Fox Colorings, and conclude the chapter with an example of the Fox Coloring Number Invariant.

In Chapter II, we explore the derivation and utilization …


Developing Collaboration And Community Through An Online Virtual Modality: Participatory Action Research, Jennifer Reed Jan 2026

Developing Collaboration And Community Through An Online Virtual Modality: Participatory Action Research, Jennifer Reed

Doctor of Education Dissertations

This action research study examined educators’ perceptions of collaboration and community within a virtual professional learning community and investigated how participation influenced collaborative actions over time. The study also compared the needs and goals of secondary and postsecondary educators participating in a shared VPLC model. Grounded in the Community of Inquiry and Online Collaborative Learning theoretical frameworks, this study addressed a growing need for effective, flexible professional learning structures that support collaboration across educational contexts. Data were collected from six educators, including three secondary and three postsecondary instructors, through pre- and post-administration of the Professional Learning Community Assessment–Revised, recorded virtual …


Uncertainty Quantification, Propagation & Conjunction Assessment In Orbital Mechanics Using Generalized Polynomial Chaos Expansion & 2-Dimensional Conjunction Plane Analysis Techniques, Monalisa Karim Jan 2026

Uncertainty Quantification, Propagation & Conjunction Assessment In Orbital Mechanics Using Generalized Polynomial Chaos Expansion & 2-Dimensional Conjunction Plane Analysis Techniques, Monalisa Karim

Mechanical and Aerospace Engineering Theses

Uncertainties, that are inherent to dynamic models, can be associated with state initial conditions, force modelling errors, navigation and actuation errors. In system modelling stochastic differential equations are used to represent dynamic phenomena with uncertainties, for which the solutions are probability density functions of quantities of interest characterizing the realization of the stochastic processes. In Polynomial Chaos Expansion (PCE) propagation, these solutions are represented as weighted sums of multivariate spectral polynomials that are functions of the input random variables. Generalized polynomial chaos expansion (gPC) is an extension to the original homogenous PCE which projects the random solution onto a basis …


Adaptive Control For A Robotic Bipedal Device Using A Hybrid Discrete-Continuous Reinforcement Learning Strategy, Karla Rincon-Martinez, Wen Yu, Isaac Chairez Jan 2026

Adaptive Control For A Robotic Bipedal Device Using A Hybrid Discrete-Continuous Reinforcement Learning Strategy, Karla Rincon-Martinez, Wen Yu, Isaac Chairez

Mathematics Faculty Publications

This research develops and implements a novel reinforcement learning (RL) architecture to address the trajectory-tracking problem in bipedal robotic systems under articulated-joint constraints. The proposed RL framework extends previously designed adaptive controllers characterized by state-dependent gain structures. The learning mechanism comprises two hierarchical adaptation layers: the first employs an adaptive dynamic programming (ADP) formulation to approximate the Bellman value function using a class of continuous-time dynamic neural networks. In contrast, the second uses an iterative optimization scheme based on the deep deterministic policy gradient (DDPG) algorithm. The resulting control strategy minimizes a robust performance index defined over the tracking trajectories …


A Note On Asymptotics Of Estimators For Axially Symmetric Processes On The Sphere, Haimeng Zhang, Chunfeng Huang, Xiaohuan Xue, A.L.A.R.R. Thanuja, Bukola O. Adaramola Jan 2026

A Note On Asymptotics Of Estimators For Axially Symmetric Processes On The Sphere, Haimeng Zhang, Chunfeng Huang, Xiaohuan Xue, A.L.A.R.R. Thanuja, Bukola O. Adaramola

Research, Publications & Creative Work

Axially symmetric processes, those stationary in longitude but nonstationary across latitude, provide a flexible and physically meaningful class of models for global environmental data. Despite their wide use, the asymptotic properties of classical method-of-moments (MOM) estimators for these processes remain largely unexamined. In this work, we investigate MOM estimators of covariances and cross-variograms for axially symmetric Gaussian processes observed on regular latitude-longitude grids. First, we show that MOM covariance estimators are asymptotically biased. We then examine MOM estimators of cross-variograms, and prove that they are unbiased. However, using the block circulant structure of the covariance matrix and its Fourier diagonalization, …


Delaying Cancer Progression By Integrating Toxicity Constraints In A Model Of Adaptive Therapy, Jana L. Gevertz, Harsh Vardhan Jain, Irina Kareva, Kathleen P. Wilkie, Joel Brown, Yitong Pepper Huang, Eduardo Sontag, Vladimir Vinogradov, Mark Davies Jan 2026

Delaying Cancer Progression By Integrating Toxicity Constraints In A Model Of Adaptive Therapy, Jana L. Gevertz, Harsh Vardhan Jain, Irina Kareva, Kathleen P. Wilkie, Joel Brown, Yitong Pepper Huang, Eduardo Sontag, Vladimir Vinogradov, Mark Davies

Mathematics Sciences: Faculty Publications

Cancer therapies often fail when intolerable toxicity or drug-resistant cancer cells undermine otherwise effective treatment strategies. Over the past decade, adaptive therapy has emerged as a promising approach to postpone emergence of resistance by altering dose timing based on tumor burden thresholds. Despite encouraging results, these protocols often overlook the crucial role of toxicity-induced treatment breaks, which may permit tumor regrowth. Herein, we explore the following question: would incorporating toxicity feedback improve or hinder the efficacy of adaptive therapy? To address this question, we propose a mathematical framework for incorporating toxic feedback into treatment design. We and that the degree …