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The Importance Of Solvents In Obtaining Gossypol Free Cotton Meal In The Extraction Process, Dilshod A. Nasredinov, Aslbek B. Yulchiyev, Kamar P. Serkaev Aug 2025

The Importance Of Solvents In Obtaining Gossypol Free Cotton Meal In The Extraction Process, Dilshod A. Nasredinov, Aslbek B. Yulchiyev, Kamar P. Serkaev

CHEMISTRY AND CHEMICAL ENGINEERING

Comparative, analytical and experimental studies of methods for obtaining vegetable oils from oilseeds have been conducted, the purpose was to determine the advantages and disadvantages of technologies used in industry. As the experimental results have shown, among the existing methods of oil production, the method of direct extraction is promising, which provides 12% more water-soluble proteins while observing the technological regimes developed for each type of oil raw materials. Based on the fact that the current level of scientific and technological progress allows the use of targeted solvents and if necessary sequence of several extractants that provides isolation of a …


Improvement Of Flax Seeds Processing Technology For The Production Of Functional Oil Products, Manzura N. Hafizova, Ismoil B. Isabaev, Nафиса R. Djurayeva, Suvankul S. Ravshanov Aug 2025

Improvement Of Flax Seeds Processing Technology For The Production Of Functional Oil Products, Manzura N. Hafizova, Ismoil B. Isabaev, Nафиса R. Djurayeva, Suvankul S. Ravshanov

CHEMISTRY AND CHEMICAL ENGINEERING

One of the main problems of our time is the sharp increase in alimentary-dependent diseases or so-called "diseases of civilization" caused by unbalanced nutrition, namely a stable deficiency or excess of nutrients with food relative to the physiological human needs. Therefore, recently there has been an increased interest in the production of functional products with a relatively balanced composition of certain nutrients depending on their purpose and intended use. A promising object of modification is traditional fat products, the transformation of which into functional ones is carried out by combining various types of raw materials, i.e., by creating composite (model) …


Microbiome–Immune Interaction And Harnessing For Next-Generation Vaccines Against Highly Pathogenic Avian Influenza In Poultry, Yongming Sang, Samuel N. Nahashon, Richard J. Webby Aug 2025

Microbiome–Immune Interaction And Harnessing For Next-Generation Vaccines Against Highly Pathogenic Avian Influenza In Poultry, Yongming Sang, Samuel N. Nahashon, Richard J. Webby

Food and Animal Sciences Faculty Research

Highly pathogenic avian influenza (HPAI) remains a persistent threat to global poultry production and public health. Current vaccine platforms show limited cross-clade efficacy and often fail to induce mucosal immunity. Recent advances in microbiome research reveal critical roles for gut commensals in modulating vaccine-induced immunity, including enhancement of mucosal IgA production, CD8+ T-cell activation, and modulation of systemic immune responses. Engineered commensal bacteria such as Lactococcus lactis, Bacteroides ovatus, Bacillus subtilis, and Staphylococcus epidermidis have emerged as promising live vectors for antigen delivery. Postbiotic and synbiotic strategies further enhance protective efficacy through targeted modulation of the gut microbiota. Additionally, artificial …


Exploring Factors Affecting The Adoption And Use Of Digital Health Technologies Among Older Adults With Cancer: A Qualitative Study, Misun Hwang, Youmin Cho, Katie Gahn, Heidi Mason, Milisa Manojlovich, Yang Gong, Yun Jiang Aug 2025

Exploring Factors Affecting The Adoption And Use Of Digital Health Technologies Among Older Adults With Cancer: A Qualitative Study, Misun Hwang, Youmin Cho, Katie Gahn, Heidi Mason, Milisa Manojlovich, Yang Gong, Yun Jiang

Faculty, Staff and Student Publications

Purpose: Although digital health technologies (DHTs) are promising to improve health outcomes in older adults with cancer, the low adoption and limited use remain significant gaps in their effective digital health care. Little is known about their concerns about adopting and using DHTs in routine life, particularly in the continued use phase. This study aims to explore factors affecting the initial adoption and continued use of DHTs among older adults with cancer.

Methods: A secondary analysis of qualitative data was conducted based on interviews with 21 older adults (≥ 65 years) with breast, prostate, lung, or colorectal cancer. The transcripts …


Managing Undesirable Vegetation Transitions On The Landscape: A Study Of Perceptions Of Conservation Professionals In Nebraska And Montana, Anubrata Deka, Simanti Banerjee, Theresa Floyd Aug 2025

Managing Undesirable Vegetation Transitions On The Landscape: A Study Of Perceptions Of Conservation Professionals In Nebraska And Montana, Anubrata Deka, Simanti Banerjee, Theresa Floyd

Cornhusker Economics

In this bulletin, we have provided a descriptive analysis of the perceptions of conservation professionals in Nebraska and Montana, two states where the rangeland ecosystem is facing a large-scale transition from native grasses to invasive trees and grasses. This analysis provides an initial understanding of the different factors that can influence adoption of policy initiatives by conservation professionals. When considered alongside insights into the management behaviors of ranchers—whose productivity and profitability are adversely affected by these transitions—this information helps form a more comprehensive picture of the ecological and economic impacts of UVTs, as well as strategies for their mitigation. In …


Application And Comparison Of Satellite-Derived Sea Surface Temperature Gradients To Identify Seasonal And Interannual Variability Off The California Coast: Preliminary Results And Future Perspectives, Jorge Vazquez-Cuervo, Marisol García-Reyes, David S. Wethey, Daniele Ciani, Jose Gomez-Valdes Aug 2025

Application And Comparison Of Satellite-Derived Sea Surface Temperature Gradients To Identify Seasonal And Interannual Variability Off The California Coast: Preliminary Results And Future Perspectives, Jorge Vazquez-Cuervo, Marisol García-Reyes, David S. Wethey, Daniele Ciani, Jose Gomez-Valdes

Faculty Publications

The application of satellite-derived sea surface temperature in coastal regions is critical for resolving the dynamics of frontal features and coastal upwelling. Here, we examine and compare sea surface temperature (SST) gradients derived from two satellite products, the Multi-Scale Ultra-High Resolution SST Product (MUR, 0.01° grid scale) and the Operational SST and Ice Analysis (OSTIA, 0.05° grid scale), available through the Group for High Resolution SST (GHRSST). Both products show similar seasonal variability, with maxima occurring in the summer time frame. Additionally, both products show an increasing trend of SST gradients near the coast. However, differences exist between the two …


A 12,800-Year-Old Layer With Cometary Dust, Microspherules, And Platinum Anomaly Recorded In Multiple Cores From Baffin Bay, Christopher R. Moore, Vladimir A. Tselmovich, Malcolm A. Lecompte, Allen West, Stephen J. Culver, David J. Mallinson, Mohammed Baalousha M.Sc, Ph.D., James P. Kennett, William M. Napier, Michael Bizimis, Victor Adedeji, Seth R. Sutton, Gunther Kleteschka, Kurt A. Langworthy, Jesus P. Perez, Timothy Witwer, Marc D. Young, Jordan Jeffreys, Richard C. Greenwood, James A. Malley Aug 2025

A 12,800-Year-Old Layer With Cometary Dust, Microspherules, And Platinum Anomaly Recorded In Multiple Cores From Baffin Bay, Christopher R. Moore, Vladimir A. Tselmovich, Malcolm A. Lecompte, Allen West, Stephen J. Culver, David J. Mallinson, Mohammed Baalousha M.Sc, Ph.D., James P. Kennett, William M. Napier, Michael Bizimis, Victor Adedeji, Seth R. Sutton, Gunther Kleteschka, Kurt A. Langworthy, Jesus P. Perez, Timothy Witwer, Marc D. Young, Jordan Jeffreys, Richard C. Greenwood, James A. Malley

Faculty Publications

The Younger Dryas Impact Hypothesis (YDIH) posits that ~12,800 years ago Earth encountered the debris stream of a disintegrating comet, triggering hemisphere-wide airbursts, atmospheric dust loading, and the deposition of a distinctive suite of extraterrestrial (ET) impact proxies at the Younger Dryas Boundary (YDB). Until now, evidence supporting this hypothesis has come only from terrestrial sediment and ice-core records. Here we report the first discovery of similar impact-related proxies in ocean sediments from four marine cores in Baffin Bay that span the YDB layer at water depths of 0.5–2.4 km, minimizing the potential for modern contamination. Using scanning electron microscopy …


Nutrition Anthropology In Global Malnutrition In Children Under Five, Katherine Michelle Dennison Owens Aug 2025

Nutrition Anthropology In Global Malnutrition In Children Under Five, Katherine Michelle Dennison Owens

Doctoral Dissertations and Projects

Food is essential to growth and development for people and nations. Too little or too much food can lead to undernutrition or overweight, both forms of malnutrition. While there have been improvements in undernutrition, overweight is increasing, causing the double burden of malnutrition globally, which is especially true in low-income and middle-income countries. Understanding nutrition anthropology's economic, environmental, and socio-cultural factors is critical to combat malnutrition's burden in different populations. Shaping policies and investments in malnutrition need to be strategic to have a measurable impact on malnutrition improvements. This study identified nutrition anthropology factors using six economic, environmental, and socio-cultural …


Spirituality And Perceived Insider Status: A Study Of Organizational Commitment Of African American Female Leaders In Fortune 1000 Companies, Toni Y. Stubbs Aug 2025

Spirituality And Perceived Insider Status: A Study Of Organizational Commitment Of African American Female Leaders In Fortune 1000 Companies, Toni Y. Stubbs

Doctoral Dissertations and Projects

This quantitative study examined the relationships among spirituality, perceived insider status, and organizational commitment among African American female leaders within Fortune 1000 companies. Using a cross-sectional design, the research gathered data from 119 participants through online surveys that included the Spiritual Well-Being Scale (SWBS), the Perceived Insider Status Scale (PIS), and the Organizational Commitment Questionnaire (OCQ). Analyses included Pearson correlations and mediation modeling to address the research questions. The results revealed a strong, statistically significant relationship between perceived insider status and organizational commitment. Although spirituality did not directly predict organizational commitment, it demonstrated a small but significant mediating effect between …


Social Networks And The Demand For Credence Agricultural Technologies, Yurani Arias-Granada, Jonathan Bauchet, Jacob Ricker-Gilbert, Kajal Gulati Aug 2025

Social Networks And The Demand For Credence Agricultural Technologies, Yurani Arias-Granada, Jonathan Bauchet, Jacob Ricker-Gilbert, Kajal Gulati

Department of Agricultural Economics Faculty Publications

Little is known about the adoption of agricultural technologies that enhance unobservable attributes, such as food quality and food safety. Social networks can potentially be a key tool to disseminate information about such technologies, because informal discussions among network members could counter the lack of observability and awareness of the benefits of such technologies. To inform this issue, we conducted a field experiment that included experimental auctions and a lottery to estimate how social networks influence the demand for Aflasafe, a new food safety-enhancing technology, among smallholder farmers in Senegal. Aflasafe is an agricultural input that controls aflatoxins, which are …


Development Of A Physiologically Based Pharmacokinetic (Pbpk) Model And Evaluation Of Antioxidant Capacity For Polypodium Leucotomos Extract, Christopher L. Basel Aug 2025

Development Of A Physiologically Based Pharmacokinetic (Pbpk) Model And Evaluation Of Antioxidant Capacity For Polypodium Leucotomos Extract, Christopher L. Basel

Doctoral Dissertations and Projects

The purpose of this study was to develop an equation to calculate the approximate concentration of active components in orally administered Polypodium leucotomos fern extract (PLE) and to develop physiologically based pharmacokinetic (PBPK) models for an active component of PLE or its metabolite to address the need for human pharmacokinetics (PK). Model differences based on ethnic groups were also investigated. This was a quantitative study using secondary data. It has been estimated that skin cancers account for approximately 40% of all human cancers and that approximately 13,000 people will die of skin cancer in 2024. People with darker skin experience …


Evaluation Of Diet Quality, Physical Health, And Mental Health Baseline Data From A Wellness Intervention For Individuals Living In Transitional Housing, Callie Millward, Kyle Lyman, Soonwye Lucero, James D. Lecheminant, Cindy Jenkins, Kristi Strongo, Gregory Snow, Heidi Leblanc, Lea Palmer, Rickelle Richards Aug 2025

Evaluation Of Diet Quality, Physical Health, And Mental Health Baseline Data From A Wellness Intervention For Individuals Living In Transitional Housing, Callie Millward, Kyle Lyman, Soonwye Lucero, James D. Lecheminant, Cindy Jenkins, Kristi Strongo, Gregory Snow, Heidi Leblanc, Lea Palmer, Rickelle Richards

All Current Publications

Background/Objectives: The aim of this study was to evaluate baseline health measurements among transitional housing residents (n = 29) participating in an 8-week pilot wellness intervention. Methods: Researchers measured anthropometrics, body composition, muscular strength, cardiovascular indicators, physical activity, diet quality, and health-related perceptions. Researchers analyzed data using descriptive statistics and conventional content analysis. Results: Most participants were male, White, and food insecure. Mean BMI (31.8 ± 8.6 kg/m2 ), waist-to-hip ratio (1.0 ± 0.1 males, 0.9 ± 0.1 females), body fat percentage (25.8 ± 6.1% males, 40.5 ± 9.4% females), blood pressure (131.8 ± 17.9/85.2 ± 13.3 mmHg), and …


Radioactive Contamination And Climate Warming Affect Physiological Performance Of Chornobyl Barn Swallows, Zbyszek Boratyríski, Timothy Mousseau, Anders Pape Møller Aug 2025

Radioactive Contamination And Climate Warming Affect Physiological Performance Of Chornobyl Barn Swallows, Zbyszek Boratyríski, Timothy Mousseau, Anders Pape Møller

Faculty Publications

Global warming and degradation of natural habitats are the two main factors causing ecophysiological stress on individuals and risk for biodiversity. Hyperthermia is a common response to stress in homeothermic animals, in particular to heat, pathogens and environmental contamination. Resilience of biological systems to global warming may be deteriorated in polluted habitats. Here we investigated how body temperature of a wild bird, the barn swallow (Hirundo rustica), responded to global warming while simultaneously exposed to radioactive contamination from the Chernobyl accident. Our results showed that both high air temperatures (t = 15.55, df = 335, p <  0.0001) and elevated environmental radioactive contamination (t = 5.18, df = 8.09, p = 0.0008) increased internal body temperature of individuals. The additive effect suggests that birds might suffer hyperthermia in locally contaminated habitat (1.47% body temperature increase) while simultaneously exposed to globally rising temperatures (1.95% body temperature increase), potentially reducing the fitness of individual and the maintenance of breeding colonies. The cumulative and interactive negative effects of multiple stressors, such as those emerging from increasing habitat degradation and climate change, will likely contribute to biodiversity losses globally.


Immunomodulatory Effects Of Gold Nanoparticles: Impacts On Immune Cells And Mechanisms Of Action, Khadijeh Koushki, Prapannajeet Biswal, Geraldine Vidhya Vijay, Mahvash Sadeghi, Sajad Dehnavi, Ngoc Tuyet Tra, Sai Kumar Samala, Mahdieh Yousefi Taba, Arjun Balaji Vasan, Emily Han, Yuri Mackeyev, Sunil Krishnan Aug 2025

Immunomodulatory Effects Of Gold Nanoparticles: Impacts On Immune Cells And Mechanisms Of Action, Khadijeh Koushki, Prapannajeet Biswal, Geraldine Vidhya Vijay, Mahvash Sadeghi, Sajad Dehnavi, Ngoc Tuyet Tra, Sai Kumar Samala, Mahdieh Yousefi Taba, Arjun Balaji Vasan, Emily Han, Yuri Mackeyev, Sunil Krishnan

Faculty, Staff and Student Publications

Traditional anti-inflammatory medications-such as corticosteroids, biological agents, and non-steroidal anti-inflammatory drugs-are commonly employed to mitigate inflammation, despite their potential for debilitating side effects. There is a growing need for alternative next-generation therapies for symptomatic, unchecked, and/or detrimental inflammation with more favorable adverse effect profiles. The long history of use of gold salts as anti-inflammatory agents and the more recent exploration of gold nanoparticle (AuNP) formulations for clinical indications suggest that the targeted delivery of nanoparticles to inflammatory sites may be a promising approach worth investigating. Coupled with peptides that specifically target immune cells, AuNPs could potently counteract inflammation. Here, we …


Racial And Ethnic Disparities In Receipt Of Guideline-Concordant Pancreatic Cancer Care Among Older Adults In The United States, Joshua Herb, Kai-Ping Liao, John K Lin, Kever A Lewis, Sharon H Giordano, Matthew H G Katz, Rebecca A Snyder Aug 2025

Racial And Ethnic Disparities In Receipt Of Guideline-Concordant Pancreatic Cancer Care Among Older Adults In The United States, Joshua Herb, Kai-Ping Liao, John K Lin, Kever A Lewis, Sharon H Giordano, Matthew H G Katz, Rebecca A Snyder

Faculty, Staff and Student Publications

Purpose: Patients racialized as Black experience a higher mortality from pancreatic cancer (PC). Worse survival outcomes may relate to differences in delivered treatment. This study examined differences in receipt of guideline-concordant care (GCC) among older adults with PC according to race and ethnicity.

Methods: Patients 65 years and older with incident PC racialized as non-Hispanic White (NH-White) or racialized as NH-Black or of Hispanic ethnicity were identified in the SEER-Medicare database from 2004 to 2019. The primary outcome was receipt of stage-specific GCC. Multivariable logistic regression identified factors associated with GCC. Oaxaca-Blinder decomposition examined the contribution of measured and unmeasured …


Antifungal Peptides From Casein Milk Of Etawa Crossbreed (Capra Hircus) As Biopreservation Agent For Bread And Molecular Docking Studies, Dian Riana Ningsih, Winarto Haryadi, Rachma Wikandari, Tri Joko Raharjo Aug 2025

Antifungal Peptides From Casein Milk Of Etawa Crossbreed (Capra Hircus) As Biopreservation Agent For Bread And Molecular Docking Studies, Dian Riana Ningsih, Winarto Haryadi, Rachma Wikandari, Tri Joko Raharjo

Karbala International Journal of Modern Science

Bread without peptide fraction treatment started to grow mold on the fourth day with a total of 24x107 fungi colonies/ml. Meanwhile, the addition of peptide fractions GMC5, GMC6, GMC7, and GMC8 effectively preserved bread for up to 4 days, indicated by no mold growth. The best treatment was the GMC6 peptide fraction on day 8 which grew the least amount of fungus at 7x107 spores/ml. Peptide interaction with the CaATPase receptor Aspergillus sp. was carried out using HADDOCK 2.4. The 3D CaATPase structure prediction resulted in a model with good structural quality. This was supported by residues in …


Scorpions Of The Horn Of Africa (Arachnida: Scorpiones). Part Xlii. Parabuthus Qaraaf Sp. N. From Ethiopia (Buthidae), František Kovařík, Hassan Sh A. Elmi Aug 2025

Scorpions Of The Horn Of Africa (Arachnida: Scorpiones). Part Xlii. Parabuthus Qaraaf Sp. N. From Ethiopia (Buthidae), František Kovařík, Hassan Sh A. Elmi

Euscorpius

No abstract provided.


Dosimetric Comparison Of Dynamic Conformal Arc Using Ezfluence Versus Dynamic Conformal Arc With A Posterior Static Field, A Retrospective Thoracic Spine Study, Michelle Klemm Aug 2025

Dosimetric Comparison Of Dynamic Conformal Arc Using Ezfluence Versus Dynamic Conformal Arc With A Posterior Static Field, A Retrospective Thoracic Spine Study, Michelle Klemm

Masters Projects

Purpose

Spinal metastases are a common complication of advanced cancer, often requiring palliative radiation therapy. This study compares two dynamic conformal arc (DCA) based techniques for thoracic spine metastases: a single arc plan generated using EZFluence and a hybrid technique combining DCA with a posterior-anterior (PA) static field. The goal was to evaluate dosimetric differences in target coverage and organ-at-risk (OAR) sparing.

Methods

Ten thoracic spine computed tomography (CT) datasets from The Cancer Imaging Archive were retrospectively planned with both techniques using Eclipse v16.0. Each plan prescribed 3000 cGy in 10 fractions to a planning target volume (PTV) encompassing T5–T9 …


Advancing Single-Molecule Nanopore Sensing: From Protein Conformation And Metal Binding To Dna Transport Via Hybrid Nanostructures, Matthew J. Odonohue Aug 2025

Advancing Single-Molecule Nanopore Sensing: From Protein Conformation And Metal Binding To Dna Transport Via Hybrid Nanostructures, Matthew J. Odonohue

Multidisciplinary Studies Theses and Dissertations

This dissertation presents the development and application of solid-state and hybrid nanopore platforms for single-molecule analysis of biomolecular interactions. First, a silicon nitride nanopore was employed to characterize the conformational states of the transferrin receptor (TfR), enabling discrimination between its monomeric and dimeric forms, as well as from its ligand, human serum transferrin (hSTf), despite their similar molecular weights. In a separate study, the same nanopore configuration was used to track the real-time binding of titanium ions to transferrin, demonstrating single-molecule sensitivity to metal-induced conformational changes. A hybrid microtubule–solid-state nanopore (MT–SSN) was then engineered, repurposing microtubules as electrostatically anchored conduits …


Novel Nanomaterials For Developing Bone Scaffolds And Tissue Regeneration, Nazim Uddin Emon, Lu Zhang, Shelby Dawn Osborne, Mark Allen Lanoue, Yan Huang, Z. Ryan Tian Aug 2025

Novel Nanomaterials For Developing Bone Scaffolds And Tissue Regeneration, Nazim Uddin Emon, Lu Zhang, Shelby Dawn Osborne, Mark Allen Lanoue, Yan Huang, Z. Ryan Tian

Cell and Molecular Biology Faculty Publications and Presentations

Nanotechnologies bring a rapid paradigm shift in hard and soft bone tissue regeneration (BTR) through unprecedented control over the nanoscale structures and chemistry of biocompatible materials to regenerate the intricate architecture and functional adaptability of bone. This review focuses on the transformative analyses and prospects of current and next-generation nanomaterials in designing bioactive bone scaffolds, emphasizing hierarchical architecture, mechanical resilience, and regenerative precision. Mainly, this review elucidated the innovative findings, new capabilities, unmet challenges, and possible future opportunities associated with biocompatible inorganic ceramics (e.g., phosphates, metallic oxides) and the United States Food and Drug Administration (USFDA) approved synthetic polymers, including …


Dopaminergic Neurons In The Zebrafish Subpallium Belong To The Extended Medial Amygdala, Daniel Armbruster, Thomas Mueller, Wolfgang Driever Aug 2025

Dopaminergic Neurons In The Zebrafish Subpallium Belong To The Extended Medial Amygdala, Daniel Armbruster, Thomas Mueller, Wolfgang Driever

Department of Biology Faculty Scholarship and Creative Works

The amygdala is a heterogeneous, multinuclear telencephalic structure critical for motivated and emotion-related behaviors in vertebrates. In ray-finned fish (Actinopterygii) like the teleost zebrafish, a telencephalic outward-growing process called eversion makes defining amygdaloid territories particularly challenging. Teleosts are also peculiar in that they develop numerous dopaminergic (DA) neurons in the subpallium, while in tetrapods, such populations are less prominent or appear only transiently. To shed light on the organization of the amygdala in teleosts, we pursued an evolutionary developmental approach focusing on the topological origin of subpallial DA neurons. Specifically, we analyzed the distribution of tyrosine hydroxylase (Th) in conjunction …


Recreation Effects On Soil Carbon, Biocrust Presence, Soil Stability, And Invasive Species In Indian Creek, Bears Ears National Monument, Elisabeth M. Currit Aug 2025

Recreation Effects On Soil Carbon, Biocrust Presence, Soil Stability, And Invasive Species In Indian Creek, Bears Ears National Monument, Elisabeth M. Currit

Theses and Dissertations

Desert ecosystems perform essential ecosystem services, including playing a crucial role in the global carbon cycle. Because of this, it is important to understand how recreational activities, common in desert environments, impacts dryland ecosystems' ability to perform ecosystem services. The growing popularity of outdoor recreation in Western US poses a threat to desert ecosystems, and unregulated activities can harm soil health, particularly the presence and functioning of biological soil crusts (biocrusts). This study uses the Indian Creek Special Recreation Management area in Bears Ears National Monument, Utah, USA, as a case study for recreation impacted desert ecosystems. It examines the …


Exploring Soil-Derived Antimicrobials For Inhibiting Dairy-Associated Pathogens And Spoilage Bacteria, Michael Joseph Moran Aug 2025

Exploring Soil-Derived Antimicrobials For Inhibiting Dairy-Associated Pathogens And Spoilage Bacteria, Michael Joseph Moran

Theses and Dissertations

Spore-forming bacteria are among the most problematic contaminants in fluid milk. They can survive pasteurization, grow at refrigeration temperatures, and secrete heat-stable enzymes, making them a major cause of spoilage in both pasteurized and reconstituted milk products. Current nonthermal strategies for reducing spore counts, including microfiltration and bactofugation, are often costly and inconsistent. The increasing consumer demand for natural additives in food products has sparked interest in the use of bacterially-derived antimicrobial compounds, particularly those from generally recognized as safe (GRAS) organisms, as an alternative method of dairy preservation. This study explores the antimicrobial potential of ten soil-derived Bacillus and …


Lakota Plant Lesson Connecting Science And Culture For 2nd Graders, Jade M. Jupackal, Larry Browning, Matt Miller, Jiyul Chang, Srinivas Janaswamy, Lydia Yellow Hawk, Jessica Larson, Michael Prate, Madhav P. Nepal Aug 2025

Lakota Plant Lesson Connecting Science And Culture For 2nd Graders, Jade M. Jupackal, Larry Browning, Matt Miller, Jiyul Chang, Srinivas Janaswamy, Lydia Yellow Hawk, Jessica Larson, Michael Prate, Madhav P. Nepal

iLEARN Teaching Resources

In this lesson, 2nd graders will learn about how the Lakota people use plants and why these plants are special. They will also discover the important parts of a plant—roots, stem, leaves, flowers, and seeds. Students will engage in activities like coloring, drawing, and exploring real plants found in schoolyard to help them understand each plant part and its function. This culturally responsive lesson blends science with experiential learning and emphasizes plant-people relationships. By the end, students will complete an art-based assessment to demonstrate understanding.


Phase 2 Study Of Zilovertamab Vedotin In Participants With Metastatic Solid Tumors, Funda Meric-Bernstam, Martin Gutierrez, Enrique Sanz-Garcia, Diego Villa, Jun Zhang, Jennifer Friedmann, Fengting Yan, Mark A Socinski, John Sarantopoulos, Luis E Raez, Quincy S Chu, Maxime Chénard-Poirier, Manash Chatterjee, Hong Ren, Qi Liu, Douglas A Levine, Komal L Jhaveri Aug 2025

Phase 2 Study Of Zilovertamab Vedotin In Participants With Metastatic Solid Tumors, Funda Meric-Bernstam, Martin Gutierrez, Enrique Sanz-Garcia, Diego Villa, Jun Zhang, Jennifer Friedmann, Fengting Yan, Mark A Socinski, John Sarantopoulos, Luis E Raez, Quincy S Chu, Maxime Chénard-Poirier, Manash Chatterjee, Hong Ren, Qi Liu, Douglas A Levine, Komal L Jhaveri

Faculty, Staff and Student Publications

Purpose: Zilovertamab vedotin, an antibody‒drug conjugate targeting receptor tyrosine kinase‒like orphan receptor 1 (ROR1), had manageable safety and promising antitumor activity in participants with relapsed or refractory non-Hodgkin lymphomas. We evaluated zilovertamab vedotin in participants with previously-treated metastatic solid tumors.

Methods: This phase 2, open-label, nonrandomized study (NCT04504916) enrolled participants with metastatic triple-negative breast cancer, hormone receptor‒positive (HR+) breast cancer, nonsquamous non‒small-cell lung cancer, platinum-resistant ovarian cancer, or pancreatic cancer. Participants received zilovertamab vedotin ≤2.5 mg/kg once every 3 weeks (Q1/3W) or < 1.75 mg/kg twice every 3 weeks (Q2/3W). Primary endpoint was objective response rate (ORR) per RECIST v1.1 by blinded independent central review. ROR1 protein expression was correlated with clinical outcomes.

Results: 102 participants were enrolled (Q1/3W, n=70; Q2/3W, n=32). ORR was 1% (95% CI, 0%‒8%) with …


Interactive 3d Segmentation For Primary Gross Tumor Volume In Oropharyngeal Cancer, Mikko Saukkoriipi, Jaakko Sahlsten, Joel Jaskari, Lotta Orsmaa, Jari Kangas, Nastaran Rasouli, Roope Raisamo, Jussi Hirvonen, Helena Mehtonen, Jorma Järnstedt, Antti Mäkitie, Mohamed Naser, Clifton Fuller, Benjamin Kann, Kimmo Kaski Aug 2025

Interactive 3d Segmentation For Primary Gross Tumor Volume In Oropharyngeal Cancer, Mikko Saukkoriipi, Jaakko Sahlsten, Joel Jaskari, Lotta Orsmaa, Jari Kangas, Nastaran Rasouli, Roope Raisamo, Jussi Hirvonen, Helena Mehtonen, Jorma Järnstedt, Antti Mäkitie, Mohamed Naser, Clifton Fuller, Benjamin Kann, Kimmo Kaski

Faculty, Staff and Student Publications

Radiotherapy is the main treatment modality of oropharyngeal cancer (OPC), in which an accurate segmentation of primary gross tumor volume (GTVt) is essential but also challenging due to significant interobserver variability and the time consumed in manual tumor delineation. For such a challenge an interactive deep learning (DL) based approach offers the advantage of automatic high-performance segmentation with the flexibility for user correction when necessary. In this study, we investigate an interactive DL for GTVt segmentation in OPC by introducing a novel two-stage Interactive Click Refinement (2S-ICR) framework and implementing state-of-the-art algorithms. Using the 2021 HEad and neCK TumOR dataset …


The Neurosurgeon's Role In The Brain Economy: How Strategic Investment In Neurosurgical Care And Innovation Will Improve Global Outcomes, Daniela A Perez-Chadid, Riya M Dange, Harris A Eyre, Graham Fieggen, Kerry A Vaughan, Sameer A Sheth, Jafri Malin Abdullah, Bello B Shehu, Daniel Donoho, Samuel Browd, Agustin Ibanez, Saksham Gupta, Frederick Lang, Anil Nanda, Gail Rosseau Aug 2025

The Neurosurgeon's Role In The Brain Economy: How Strategic Investment In Neurosurgical Care And Innovation Will Improve Global Outcomes, Daniela A Perez-Chadid, Riya M Dange, Harris A Eyre, Graham Fieggen, Kerry A Vaughan, Sameer A Sheth, Jafri Malin Abdullah, Bello B Shehu, Daniel Donoho, Samuel Browd, Agustin Ibanez, Saksham Gupta, Frederick Lang, Anil Nanda, Gail Rosseau

Faculty, Staff and Student Publications

No abstract provided.


Information Theory Optimization Of Signals From Small-Angle Scattering Measurements, Robert P Rambo, John A Tainer Aug 2025

Information Theory Optimization Of Signals From Small-Angle Scattering Measurements, Robert P Rambo, John A Tainer

Faculty, Staff and Student Publications

Small-angle X-ray scattering (SAXS) of particles in solution informs on the conformational states and assemblies of biological macromolecules (bioSAXS) outside of cryo- and solid-state conditions. In bioSAXS, the SAXS measurement under dilute conditions is resolution limited, and through an inverse Fourier transform, the measured SAXS intensities directly relate to the physical space occupied by the particles via the P(r)-distribution. Yet, this inverse transform of SAXS data has been historically cast as an ill-posed, ill-conditioned problem requiring an indirect approach. Here, we show that through the applications of matrix and information theories, the inverse transform of SAXS intensity data is a …


Profiling Brain Morphology For Autism Spectrum Disorder With Two Cross-Culture Large-Scale Consortia, Xue-Ru Fan, Ye He, Yin-Shan Wang, Lei Li, Lifespan Brain Chart Consortium (Lbcc), China Autism Brain Imaging Consortium (Cabic), Xujun Duan, Xi-Nian Zuo, John Blangero Aug 2025

Profiling Brain Morphology For Autism Spectrum Disorder With Two Cross-Culture Large-Scale Consortia, Xue-Ru Fan, Ye He, Yin-Shan Wang, Lei Li, Lifespan Brain Chart Consortium (Lbcc), China Autism Brain Imaging Consortium (Cabic), Xujun Duan, Xi-Nian Zuo, John Blangero

Human Genetics Publications

We explore neurodevelopmental heterogeneity in Autism Spectrum Disorder (ASD) through normative modeling of cross-cultural cohorts. By leveraging large-scale datasets from Autism Brain Imaging Data Exchange (ABIDE) and China Autism Brain Imaging Consortium (CABIC), our model identifies two ASD subgroups with distinct brain morphological abnormalities: subgroup “L” is characterized by generally smaller brain region volumes and higher rates of abnormality, while subgroup “H” exhibits larger volumes with less pronounced deviations in specific areas. Key areas, such as the isthmus cingulate and transverse temporal gyrus, were identified as critical for subgroup differentiation and ASD trait correlations. In subgroup H, the regional volume …


The Benefits Of High Phosphate Concentration (10n : 1p) And Diagonal Orientation On The Ex Situ Grow-Out Of Caribbean Coral Juveniles, Ashley Shen Aug 2025

The Benefits Of High Phosphate Concentration (10n : 1p) And Diagonal Orientation On The Ex Situ Grow-Out Of Caribbean Coral Juveniles, Ashley Shen

All HCAS Student Capstones, Theses, and Dissertations

As coral reefs keep declining, it is imperative to increase coral production ex situ for restoration, but this requires culture protocols to be optimized. This study examined the impacts of grow-out orientation and phosphate concentration (and nitrate (N): phosphate (P) ratio) on the survival and growth of Montastraea cavernosa and Pseudodiploria clivosa juveniles from 3 to 9 months old. Pristine reefs typically have low nitrate (0.12μmol/L) and low phosphate (0.03μmol/L) concentrations, leading to N:P ratios of 4-16 N: 1P. In recirculating tanks, it is difficult to lower nitrate concentrations below 25μmol/L. Here we hypothesized that increasing the phosphate concentration in …