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Articles 9301 - 9330 of 255415
Full-Text Articles in Entire DC Network
Native Ticks As A Model For The Effectiveness Of Fire As A Tool For The Management Of Cattle Fever Ticks In South Texas, Lauren P. Maestas, Sarah E. Mays Maestas, Kathleen M. Yeater, Manuel Zavala, Reyes Garcia, John A. Goolsby
Native Ticks As A Model For The Effectiveness Of Fire As A Tool For The Management Of Cattle Fever Ticks In South Texas, Lauren P. Maestas, Sarah E. Mays Maestas, Kathleen M. Yeater, Manuel Zavala, Reyes Garcia, John A. Goolsby
School of Integrative Biological & Chemical Sciences Faculty Publications
The species of cattle fever ticks (CFT) present in North America, Rhipicephalus (=Boophilus) annulatus, and R. microplus, remain an important agricultural and economic burden. The use of acaricides to control CFT has been a common practice over the past half century. However, alternative strategies for control are needed to improve the options for sustainable pest control. Fire is a tool to manage vegetation, and some evidence supports its potential for use to control ticks. We evaluated the effectiveness of fire as a management tool for ticks in South Texas. Our site was a 28.2-ha property in Cameron …
Statistical Analysis Of Multi-Endpoint Phenotypic Screening Increases Sensitivity Of Planarian Neurotoxicity Testing, Danielle Ireland, L. J. Word, Eva-Maria S. Collins
Statistical Analysis Of Multi-Endpoint Phenotypic Screening Increases Sensitivity Of Planarian Neurotoxicity Testing, Danielle Ireland, L. J. Word, Eva-Maria S. Collins
Biology Faculty Works
There is an urgent need for high-throughput screening (HTS) models to replace, refine, and/or reduce (“3Rs”) vertebrate toxicity testing. Replacing in vivo animal studies is challenging for neurotoxicity and developmental neurotoxicity (DNT), where the functional relevancy of adverse outcomes needs to be assessed on the whole organism. We previously screened the NTP 87-compound library (NTP87), consisting of known and suspected developmental neurotoxicants, and showed that planarian HTS can identify known (developmental) neurotoxicants. Because analysis methods can impact screening results, and our original analysis used the lowest-observed-effect-level (LOEL) only, we hypothesized that the use of state-of-the-art statistical analysis would increase the …
Phase 1/2 Trial Of Encorafenib, Cetuximab, And Nivolumab In Microsatellite Stable Brafv600e Metastatic Colorectal Cancer, Van K Morris, Christine M Parseghian, Vahid Bahrambeigi, Nourhan Abdelfattah, Lianchun Xiao, Anjali Agrawal, Kangyu Lin, Kanwal P S Raghav, Robert A Wolff, Arvind Dasari, Ryan W Huey, Bryan K Kee, Michael J Overman, Jason A Willis, Phat H Le, Michelle Escano, Yunyu C Baig, Kelsey Pan, David Menter, Alda L Tam, Wai C Foo, Li Shen, Hey Min Lee, Thomas D Gallup, Cori Margain, Dave Gallup, Kimal I Rajapakshe, Paola A Guerrero, Jing Wang, Ryan B Corcoran, Anirban Maitra, Kyuson Yun, Scott Kopetz
Phase 1/2 Trial Of Encorafenib, Cetuximab, And Nivolumab In Microsatellite Stable Brafv600e Metastatic Colorectal Cancer, Van K Morris, Christine M Parseghian, Vahid Bahrambeigi, Nourhan Abdelfattah, Lianchun Xiao, Anjali Agrawal, Kangyu Lin, Kanwal P S Raghav, Robert A Wolff, Arvind Dasari, Ryan W Huey, Bryan K Kee, Michael J Overman, Jason A Willis, Phat H Le, Michelle Escano, Yunyu C Baig, Kelsey Pan, David Menter, Alda L Tam, Wai C Foo, Li Shen, Hey Min Lee, Thomas D Gallup, Cori Margain, Dave Gallup, Kimal I Rajapakshe, Paola A Guerrero, Jing Wang, Ryan B Corcoran, Anirban Maitra, Kyuson Yun, Scott Kopetz
Faculty, Staff and Student Publications
The BRAF inhibitor encorafenib and anti-epidermal growth factor receptor (EGFR) antibody cetuximab modestly improve survival for patients with microsatellite stable (MSS) BRAFV600E metastatic colorectal cancer (mCRC), characterized by higher immune activation than MSS BRAFwild-type colorectal cancer (CRC). In this phase 1/2 study (NCT04017650) of 26 participants with MSS BRAFV600E mCRC who received encorafenib, cetuximab, and anti-PD-1 antibody nivolumab, we report an overall response rate of 50% (95% confidence interval [CI] 29–71) and median progression-free survival of 7.4 months (95% CI, 5.6–9.6). Transcriptomic profiling of pretreatment biopsies and extracellular vesicle RNA (evRNA) isolated from plasma show …
Circzfr/Ythdf3 Axis Drives Lymph Node Metastasis In Cervical Cancer Via Fasn Translation, Mingyi Zhou, Yan Gao, Yong Zhang, Lian He, Bo Gao, Yue Zhang, Francois X Claret, George A Calin, Danbo Wang
Circzfr/Ythdf3 Axis Drives Lymph Node Metastasis In Cervical Cancer Via Fasn Translation, Mingyi Zhou, Yan Gao, Yong Zhang, Lian He, Bo Gao, Yue Zhang, Francois X Claret, George A Calin, Danbo Wang
Faculty, Staff and Student Publications
Background: Lymph node metastasis is a key driver of poor outcomes in cervical cancer. However, the molecular mechanisms of circular RNAs (circRNAs) driving cervical cancer lymph node metastasis remain unclear.
Methods: We identified circZFR, fatty acid synthase (FASN) and YTH N6-methyladenosine RNA binding protein F3 (YTHDF3) protein expression in the cervical cancer patients with long and short disease-free survival (DFS). Functional experiments were performed to investigate the function of circZFR, FASN and YTHDF3 on cell migration and invasion. MeRIP-qPCR, RNA pulldown, RNA Immunoprecipitation (RIP), and Co-Immunoprecipitation (Co-IP) assays were executed to investigate the mechanism of circZFR regulating FASN protein expression. …
Human Interpretable Grammar Encodes Multicellular Systems Biology Models To Democratize Virtual Cell Laboratories, Jeanette A I Johnson, Daniel R Bergman, Heber L Rocha, David L Zhou, Eric Cramer, Ian C Mclean, Yoseph W Dance, Max Booth, Zachary Nicholas, Tamara Lopez-Vidal, Atul Deshpande, Randy Heiland, Elmar Bucher, Fatemeh Shojaeian, Matthew Dunworth, André Forjaz, Michael Getz, Inês Godet, Furkan Kurtoglu, Melissa Lyman, John Metzcar, Jacob T Mitchell, Andrew Raddatz, Jacobo Solorzano, Aneequa Sundus, Yafei Wang, David G Denardo, Andrew J Ewald, Daniele M Gilkes, Luciane T Kagohara, Ashley L Kiemen, Elizabeth D Thompson, Denis Wirtz, Laura D Wood, Pei-Hsun Wu, Neeha Zaidi, Lei Zheng, Jacquelyn W Zimmerman, Jude M Phillip, Elizabeth M Jaffee, Joe W Gray, Lisa M Coussens, Young Hwan Chang, Laura M Heiser, Genevieve L Stein-O'Brien, Elana J Fertig, Paul Macklin
Human Interpretable Grammar Encodes Multicellular Systems Biology Models To Democratize Virtual Cell Laboratories, Jeanette A I Johnson, Daniel R Bergman, Heber L Rocha, David L Zhou, Eric Cramer, Ian C Mclean, Yoseph W Dance, Max Booth, Zachary Nicholas, Tamara Lopez-Vidal, Atul Deshpande, Randy Heiland, Elmar Bucher, Fatemeh Shojaeian, Matthew Dunworth, André Forjaz, Michael Getz, Inês Godet, Furkan Kurtoglu, Melissa Lyman, John Metzcar, Jacob T Mitchell, Andrew Raddatz, Jacobo Solorzano, Aneequa Sundus, Yafei Wang, David G Denardo, Andrew J Ewald, Daniele M Gilkes, Luciane T Kagohara, Ashley L Kiemen, Elizabeth D Thompson, Denis Wirtz, Laura D Wood, Pei-Hsun Wu, Neeha Zaidi, Lei Zheng, Jacquelyn W Zimmerman, Jude M Phillip, Elizabeth M Jaffee, Joe W Gray, Lisa M Coussens, Young Hwan Chang, Laura M Heiser, Genevieve L Stein-O'Brien, Elana J Fertig, Paul Macklin
Faculty, Staff and Student Publications
Cells interact as dynamically evolving ecosystems. While recent single-cell and spatial multi-omics technologies quantify individual cell characteristics, predicting their evolution requires mathematical modeling. We propose a conceptual framework-a cell behavior hypothesis grammar-that uses natural language statements (cell rules) to create mathematical models. This enables systematic integration of biological knowledge and multi-omics data to generate in silico models, enabling virtual "thought experiments" that test and expand our understanding of multicellular systems and generate new testable hypotheses. This paper motivates and describes the grammar, offers a reference implementation, and demonstrates its use in developing both de novo mechanistic models and those informed …
Prefrontal Cortex Astrocytes Modulate Distinct Neuronal Populations To Control Anxiety-Like Behavior, Eunyoung Kim, Hairuo Du, Yanqi Tan, Brandon L Brown, Yaowen Chang, Blanca Díaz-Castro, Jonathan V Sweedler, Xinzhu Yu
Prefrontal Cortex Astrocytes Modulate Distinct Neuronal Populations To Control Anxiety-Like Behavior, Eunyoung Kim, Hairuo Du, Yanqi Tan, Brandon L Brown, Yaowen Chang, Blanca Díaz-Castro, Jonathan V Sweedler, Xinzhu Yu
Faculty, Staff and Student Publications
Accumulating evidence has supported diverse regulatory functions of astrocytes in different neural circuits as well as various aspects of complex behaviors. However, little is known about how astrocytes regulate different neuronal subpopulations that are linked to specific behavioral aspects within a single brain region. Here, we show that astrocytes in the medial prefrontal cortex (mPFC) encode anxiogenic environmental cues in freely behaving mice. Silencing mPFC astrocyte Ca
Tracing Priming Effects In Palsa Peat Carbon Dynamics Using A Stable Isotope-Assisted Metabolomics Approach, Christian Ayala-Ortiz, Moira Hough, Elizabeth K. Eder, David W. Hoyt, Rosalie K. Chu, Jason Toyoda, Steven J. Blazewicz, Patrick M. Crill, Ruth Varner, Scott R. Saleska, Virginia I. Rich, Malak M. Tfaily
Tracing Priming Effects In Palsa Peat Carbon Dynamics Using A Stable Isotope-Assisted Metabolomics Approach, Christian Ayala-Ortiz, Moira Hough, Elizabeth K. Eder, David W. Hoyt, Rosalie K. Chu, Jason Toyoda, Steven J. Blazewicz, Patrick M. Crill, Ruth Varner, Scott R. Saleska, Virginia I. Rich, Malak M. Tfaily
Michigan Tech Publications
Introduction: Peatlands store up to a third of global soil carbon, and in high latitudes their litter inputs are increasing and changing in composition under climate change. Although litter significantly influences peatland carbon and nutrient dynamics by changing the overall lability of peatland organic matter, the physicochemical mechanisms of this impact—and thus its full scope—remain poorly understood. Methods: We applied multimodal metabolomics (UPLC-HRMS, 1H NMR) paired with 13C Stable Isotope-Assisted Metabolomics (SIAM) to track litter carbon and its potential priming effects on both existing soil organic matter and carbon gas emissions. Through this approach, we achieved molecule-specific tracking …
Reducing Residential Landscape Water Use In Utah: Technologies And Strategies, Maya Cottam, Kendall Becker, Katlyn Stemmler, Shital Poudyal, Wesley Crump, Lewis Kogan, Scott Hotaling
Reducing Residential Landscape Water Use In Utah: Technologies And Strategies, Maya Cottam, Kendall Becker, Katlyn Stemmler, Shital Poudyal, Wesley Crump, Lewis Kogan, Scott Hotaling
All Current Publications
Water conservation is a critical issue in Utah, and several actions are already underway to help lower residential landscape water use. Strategies include smart irrigation controllers, efficient sprinkler bodies and nozzles, drip irrigation systems, soil amendments that increase water-holding capacity, and drought-tolerant grass cultivars for lawns. While additional conservation efforts will be necessary to reach sustainable water management, statewide adoption of current programs can help reduce water use and loss.
Scorpions Of The Horn Of Africa (Arachnida: Scorpiones). Part Xliii. Lanzatus Fuscipalpis Sp. N. From Ethiopia (Buthidae), František Kovařík, Graeme Lowe
Scorpions Of The Horn Of Africa (Arachnida: Scorpiones). Part Xliii. Lanzatus Fuscipalpis Sp. N. From Ethiopia (Buthidae), František Kovařík, Graeme Lowe
Euscorpius
The rare Horn of Africa buthid genus Lanzatus Kovařík, 2001, known only from Somalia and Somaliland, is recorded for the first time from Ethiopia. We describe a new species Lanzatus fuscipalpis sp. n. fully illustrated with color photographs showing its morphology, habitus, hemispermatophore, and collection sites.
Synergistic Cefiderocol-Containing Antibiotic Combinations Active Against Highly Drug-Resistant Acinetobacter Baumannii Patient Isolates With Diverse Resistance Mechanisms, Justin Halim, Andrew P. Keane, Jeannete Bouzo, Tope Aderibigbe, Jessica A. Chicola, Katie T. Nolan, Keertana Jonnalagadda, Jason X. Tran, Valerie J. Carabetta
Synergistic Cefiderocol-Containing Antibiotic Combinations Active Against Highly Drug-Resistant Acinetobacter Baumannii Patient Isolates With Diverse Resistance Mechanisms, Justin Halim, Andrew P. Keane, Jeannete Bouzo, Tope Aderibigbe, Jessica A. Chicola, Katie T. Nolan, Keertana Jonnalagadda, Jason X. Tran, Valerie J. Carabetta
Rowan-Virtua School of Osteopathic Medicine Departmental Research
BACKGROUND: Acinetobacter baumannii is a nosocomial pathogen known for rapidly developing resistance to nearly all antibiotics, including last-line agents. Cefiderocol, a novel siderophore cephalosporin, has shown in vitro activity against A. baumannii and is now used clinically, but resistance is emerging. Data on cefiderocol-based antibiotic combinations are limited.
OBJECTIVES: To evaluate the in vitro activity of cefiderocol alone and in combination with other antibiotics against XDR and PDR A. baumannii clinical isolates, and to explore resistance mechanisms underlying cefiderocol synergy.
METHODS: We tested 21 XDR/PDR clinical isolates and one NDM-1-producing strain using broth microdilution and checkerboard assays with cefiderocol and …
Deep Phenotyping Of Obesity: Electronic Health Record-Based Temporal Modeling Study, Xiaoyang Ruan, Shuyu Lu, Liwei Wang, Andrew Wen, Sameer Murali, Hongfang Liu
Deep Phenotyping Of Obesity: Electronic Health Record-Based Temporal Modeling Study, Xiaoyang Ruan, Shuyu Lu, Liwei Wang, Andrew Wen, Sameer Murali, Hongfang Liu
Faculty, Staff and Student Publications
Background: Obesity affects approximately 40% of adults and 15%-20% of children and adolescents in the United States, and poses significant economic and psychosocial burdens. Currently, patient responses to any single antiobesity medication (AOM) vary significantly, making obesity deep phenotyping and associated precision medicine important targets of investigation.
Objective: This study aimed to evaluate the potential of electronic health records (EHR) as a primary data source for obesity deep phenotyping. We conducted an in-depth analysis of the data elements and quality available from obesity patients prior to pharmacotherapy and applied a multimodal longitudinal deep autoencoder to investigate the feasibility, data requirements, …
Menopause-Related Changes In Sleep And The Associations With Cardiometabolic Health: A Narrative Review, Joshua R. Sparks, Xuewen Wang Ph.D., Faha
Menopause-Related Changes In Sleep And The Associations With Cardiometabolic Health: A Narrative Review, Joshua R. Sparks, Xuewen Wang Ph.D., Faha
Faculty Publications
This narrative review examines the complex relationship between sleep changes during the menopausal transition and cardiometabolic risks. The most common complaint about sleep is increased awakenings during sleep. Other complaints include having trouble falling asleep, waking up too early, insufficient and non-restorative sleep, and overall poor quality. Sleep determined using objective methods also indicates that greater awakenings after sleep onset are associated with the period of menopausal transition. Polysomnography recordings suggest physiological hyperarousal during sleep. Changes in other sleep metrics, such as sleep latency and sleep duration, are less consistent, and some studies suggest they may not worsen during the …
Why Are Food System Workers Excluded From Local Food Policy Councils?, Frank Sarfo, Laura-Anne Minkoff-Zern, Jonnell A. Robinson
Why Are Food System Workers Excluded From Local Food Policy Councils?, Frank Sarfo, Laura-Anne Minkoff-Zern, Jonnell A. Robinson
The Lender Center for Social Justice
This brief summarizes findings from our study that used national survey data of FPCs as well as focus groups and interviews with over 25 FPC representatives and leaders to examine the challenges and barriers that have limited FPCs’ engagement with labor issues. We also identify key obstacles to labor advocacy and offer practical recommendations for integrating labor equity into local food policy efforts.
Hunting Lease Comparisons For Wild Game Across Nebraska In 2025, Jim Jansen
Hunting Lease Comparisons For Wild Game Across Nebraska In 2025, Jim Jansen
Cornhusker Economics
The Nebraska Farm Real Estate Market Survey and Report 2024-2025 provides insight into recent trends in the market value of land and cash rental across the state. Each year, the special feature section covers topics on new or emerging issues related to the agricultural land industry in Nebraska. These topics reflect the interest expressed by panel members and readership of the Nebraska Farm Real Estate Market Highlights Reports. The special feature section in 2025 focuses on hunting rental arrangements in Nebraska, including the types of wild game commonly hunted and the value associated with leasing these rights.
Landowners seeking to …
Targeted Proteomic Analysis Identifies Acvrl1 As A Marker Of Cerebral Edema In Aneurysmal Subarachnoid Hemorrhage, Bosco Seong Kyu Yang, Lena O'Keefe, Sarah Hinds, Hua Chen, Athziry Paz, Jude Savarraj, Han-Gil Jeong, Moon-Ku Han, Aaron Gusdon, Xuefang Sophie Ren, Spiros Blackburn, Huimahn Alex Choi
Targeted Proteomic Analysis Identifies Acvrl1 As A Marker Of Cerebral Edema In Aneurysmal Subarachnoid Hemorrhage, Bosco Seong Kyu Yang, Lena O'Keefe, Sarah Hinds, Hua Chen, Athziry Paz, Jude Savarraj, Han-Gil Jeong, Moon-Ku Han, Aaron Gusdon, Xuefang Sophie Ren, Spiros Blackburn, Huimahn Alex Choi
Faculty, Staff and Student Publications
Cerebral edema (CE) is a major component of early brain injury from aneurysmal subarachnoid hemorrhage (SAH). Despite the utility of blood-based protein markers, biomarkers targeting cerebral edema have yet to be developed. We performed a targeted proteomic search analyzing 141 proteins in plasma samples taken from 80 adult patients within 48 hours after aneurysmal rupture to identify plasma biomarkers of cerebral edema. The protein expression profiles were analyzed for associations with a higher level of the subarachnoid hemorrhage early brain edema score measured in admission computed tomography scans. Five differentially expressed proteins-brorin, ectodysplasin A2 receptor, layilin, scavenger receptor class A …
First-Line Pd-1 +/- Ctla-4 Blockade In Patients With Deficient Mismatch Repair And/Or Microsatellite Instability-High Metastatic Colorectal Cancer, Vincenzo Nasca, Gabriele Tinè, Julien Taieb, Sara Lonardi, Ben Boursi, Ofer Margalit, Lisa Salvatore, Romain Cohen, Javier Ros, Margherita Ambrosini, Koen Zwart, Jeanine Roodhart, Priya Jayachandran, Michael J Overman, Maria Elena Elez, Chiara Cremolini, David Tougeron, Miriam Koopman, Thierry André, Rosalba Miceli, Filippo Pietrantonio
First-Line Pd-1 +/- Ctla-4 Blockade In Patients With Deficient Mismatch Repair And/Or Microsatellite Instability-High Metastatic Colorectal Cancer, Vincenzo Nasca, Gabriele Tinè, Julien Taieb, Sara Lonardi, Ben Boursi, Ofer Margalit, Lisa Salvatore, Romain Cohen, Javier Ros, Margherita Ambrosini, Koen Zwart, Jeanine Roodhart, Priya Jayachandran, Michael J Overman, Maria Elena Elez, Chiara Cremolini, David Tougeron, Miriam Koopman, Thierry André, Rosalba Miceli, Filippo Pietrantonio
Faculty, Staff and Student Publications
Background: Patients with deficient mismatch repair (dMMR) and/or microsatellite instability-high (MSI-H) metastatic colorectal cancer (mCRC) show marked sensitivity to immune checkpoint inhibitors (ICIs). Dual PD-1/CTLA-4 blockade with nivolumab and ipilimumab showed superior progression-free survival (PFS) over chemotherapy and anti-PD-1 monotherapy, but data on treatment-naïve patients is not available yet.
Methods: This international multicenter study included patients with dMMR/MSI-H mCRC receiving either chemotherapy with or without biologics, or anti-PD-1 monotherapy, or dual PD-1/CTLA-4 blockade as a first-line treatment. Data were adjusted using inverse probability of treatment weighting (IPTW) to account for baseline imbalances. IPTW-adjusted survival and subgroup analyses were conducted.
Results: …
Clinical Validity Of Foundationone Liquid Cdx For Detection Of Braf V600e In Colorectal Cancer, Rona Yaeger, Jean-François Martini, Lincoln Pasquina, Brian Tunquist, Xiaosong Zhang, Fatima Khaiser, Norberto Panoja Galicia, Shibing Deng, Siliang Gong, Cui Guo, Jimmy Kiely, Ta-Chou Vincent Ng, Graham Ferrier, Josep Tabernero, Scott Kopetz
Clinical Validity Of Foundationone Liquid Cdx For Detection Of Braf V600e In Colorectal Cancer, Rona Yaeger, Jean-François Martini, Lincoln Pasquina, Brian Tunquist, Xiaosong Zhang, Fatima Khaiser, Norberto Panoja Galicia, Shibing Deng, Siliang Gong, Cui Guo, Jimmy Kiely, Ta-Chou Vincent Ng, Graham Ferrier, Josep Tabernero, Scott Kopetz
Faculty, Staff and Student Publications
Background: The BRAF inhibitor encorafenib plus the anti-EGFR antibody cetuximab improved overall survival, objective response rate, and progression-free survival in previously treated BRAF V600E-mutant metastatic colorectal cancer in BEACON, a phase 3 randomized trial, leading to regulatory approval for this indication. To support rapid, plasma-based testing for BRAF V600E identification, clinical validity of a circulating tumor DNA (ctDNA)-based assay, FoundationOne®Liquid CDx (F1LCDx) was assessed, versus the reference tumor-based clinical trial assay (CTA) in liquid biopsy-evaluable samples from BEACON and commercially-obtained tissue-matched plasma samples.
Methods: Pre-treatment tissue samples were collected in BEACON to confirm BRAF mutational status using the central single …
Unrecognized And Unreported Concussions Among Community Rugby Players, Rachael Wittmer, Thomas A. Buckley, Charles Buz Swanik, Katelyn M. Costantini, Lisa Ryan, Ed Daly, Regan E. King, Arryana J. Daniels, Katherine J. Hunzinger
Unrecognized And Unreported Concussions Among Community Rugby Players, Rachael Wittmer, Thomas A. Buckley, Charles Buz Swanik, Katelyn M. Costantini, Lisa Ryan, Ed Daly, Regan E. King, Arryana J. Daniels, Katherine J. Hunzinger
Department of Exercise Science Faculty Papers
This study examined the prevalence of intentionally unreported and potentially unrecognized concussions in community rugby players and whether nondisclosure reasons vary by sex, position, or playing history. An online survey was completed by 1037 players (41.0% female; mean age 31.6 ± 11.3 years; 10.1 ± 8.1 years playing) who reported diagnosed, unreported, and unrecognized concussions. Poisson regression models estimated prevalence ratios (PRs), and Fisher's exact tests compared reasons for nondisclosure. The diagnosed, unreported, and unrecognized concussion rates were 66.5%, 32.4%, and 42.2%, respectively. Players with diagnosed concussions had a 7.2-fold higher prevalence of nondisclosure and a 2.3-fold higher prevalence of …
Comprehensive Fitness Assessment In A Professional Military Education Cohort: A Cross-Sectional Study, Daniel J. Lawson, Russell K. Lowell, C. Brooks Mobley, Katherine Frick, Nicholas C. Bordonie, Kaitlyn G. Clouse, Cameron D. Ott, Harrison C. Dimick, Nicholas R. Mauldin, Joellen M. Sefton
Comprehensive Fitness Assessment In A Professional Military Education Cohort: A Cross-Sectional Study, Daniel J. Lawson, Russell K. Lowell, C. Brooks Mobley, Katherine Frick, Nicholas C. Bordonie, Kaitlyn G. Clouse, Cameron D. Ott, Harrison C. Dimick, Nicholas R. Mauldin, Joellen M. Sefton
International Journal of Exercise Science
International Journal of Exercise Science 18(8): 811-835, 2025. Military personnel face rigorous physical and cognitive demands critical for operational readiness and long-term health. This study evaluated body composition, cognitive performance, and physical fitness metrics in non-entry-level service members to inform tailored fitness interventions. This cross-sectional study analyzed data from Air Command Staff College personnel (N = 307; 89 females, 218 males; age: 37 ± 5 years) at Air University, Maxwell Air Force Base. Participants completed assessments for body composition (body mass index [BMI], body fat percentage [%BF], fat mass index [FMI], fat-free mass index [FFMI]), flexibility (sit-and-reach test, functional reach …
The Future Of The Arab Media Industry In Utilizing Artificial Intelligence Technologies: A Foresight Study (2024 To 2034), Mohammedwesam Amer, Abdullah Mohammed Atbiqa
The Future Of The Arab Media Industry In Utilizing Artificial Intelligence Technologies: A Foresight Study (2024 To 2034), Mohammedwesam Amer, Abdullah Mohammed Atbiqa
Middle East Journal of Communication Studies
This study explores the future of the Arab media industry from 2024 to 2034 in light of the increasing integration of artificial intelligence (AI) technologies. It identifies key media sectors likely to be affected by AI—such as content creation, news production, editing, and audience engagement—and proposes strategies for effective implementation. The study employs a descriptive survey methodology grounded in the Unified Theory of Acceptance and Use of Technology (UTAUT). Data were collected via an electronic questionnaire from a purposive sample of 264 respondents across 18 Arab countries, including academic elites and media professionals working with Arab media institutions. Findings reveal …
Genomic Editing Of A Pathogenic Sequence Variant In Acta2 Rescues Multisystemic Smooth Muscle Dysfunction Syndrome In Mice, Qianqian Ding, Peiheng Gan, Zhisheng Xu, Hui Li, Lei Guo, Camryn Macdonald, Wei Tan, Efrain Sanchez-Ortiz, John R Mcanally, Yu Zhang, Dileep Karri, Lin Xu, Ning Liu, Eric N Olson
Genomic Editing Of A Pathogenic Sequence Variant In Acta2 Rescues Multisystemic Smooth Muscle Dysfunction Syndrome In Mice, Qianqian Ding, Peiheng Gan, Zhisheng Xu, Hui Li, Lei Guo, Camryn Macdonald, Wei Tan, Efrain Sanchez-Ortiz, John R Mcanally, Yu Zhang, Dileep Karri, Lin Xu, Ning Liu, Eric N Olson
Faculty, Staff and Student Publications
Background: Vascular smooth muscle cells (SMCs), the predominant cell type in the aortic wall, play a crucial role in maintaining aortic integrity, blood pressure, and cardiovascular function. Vascular SMC contractility and function depend on ACTA2 (smooth muscle α-actin 2). The pathogenic variant ACTA2 c.536G>A (p.R179H) causes multisystemic smooth muscle dysfunction syndrome, a severe disorder marked by widespread smooth muscle abnormalities, resulting in life-threatening aortic disease and high risk of early death from aneurysms or stroke. No effective treatments exist for multisystemic smooth muscle dysfunction syndrome.
Methods: To develop a comprehensive therapy for multisystemic smooth muscle dysfunction syndrome, we used …
Exposure To Zinc Oxide Nanoparticles Reveals A Death Resistance Mechanism In Dictyostelium Discoideum, Zoya Nadeem Faruqui
Exposure To Zinc Oxide Nanoparticles Reveals A Death Resistance Mechanism In Dictyostelium Discoideum, Zoya Nadeem Faruqui
Theses and Dissertations
Zinc oxide nanoparticles (ZnO NPs) are very versatile due to their multifunctional properties including unique physicochemical and antimicrobial characteristics. They are widely utilized across various fields such as biomedical, industrial fields, environmental remediation, and agriculture. Therefore, their cytotoxic effects on biological systems necessitate a deeper understanding of the cellular responses to nanoparticle exposure. This project primarily investigates the impact of ZnO NPs on the model organism Dictyostelium discoideum AX4 (social amoeba) which has not been examined before unlike a vast variety of organisms in the literature. The cytotoxic effects of ZnO NPs on Dictyostelium discoideum AX4 cells are compared with …
Emotional Development In Infancy, Claire Sanford, Samantha Gott
Emotional Development In Infancy, Claire Sanford, Samantha Gott
Florida Atlantic Undergraduate Research Journal
Developmental science has documented that infants’ emotional reactions are shaped by individual dispositions and their environment. This study investigated fear responses along with patterns of brain development in infants 6 to 10 months. Nine infant-mother dyads participated, with each infant observed twice (18 visits). An electroencephalogram (EEG) was used to analyze brain activity during resting-state and fear-eliciting conditions. Infant fear vocalizations were evaluated and coded during two conditions, i.e., an unfamiliar object (an electronic toy-spider), and an unfamiliar adult approaching. Results indicated infants’ fear vocalizations were stimuli-specific, with more fear expressed towards approaching strangers than the novel object. Findings also …
The Relationship Between Self-Reported And Observer-Rated Maternal Anxiety During Mother-Infant Interactions, Annalisa Tran, Jacqueline Hammack
The Relationship Between Self-Reported And Observer-Rated Maternal Anxiety During Mother-Infant Interactions, Annalisa Tran, Jacqueline Hammack
Florida Atlantic Undergraduate Research Journal
Research pertaining to maternal anxiety and mother-infant interactions is a rapidly growing field. The purpose of this study is to investigate the relationship between self-reported maternal anxiety ratings and observer-rated maternal anxiety scores. Thirty-nine motherinfant dyads participated in a four-minute free-play session via Zoom. The Parent Anxiety measure from the Coding Interactive Behavior scale was used to measure observed maternal anxiety. The General Anxiety Disorder-7 scale was used to measure self-reported maternal anxiety. No significant association was found between self-reported maternal anxiety and observed maternal anxiety. An exploratory analysis was conducted to compare self-reported maternal anxiety and observed maternal sensitivity. …
Exploring Infant Toy Interactions In Free Play Environments, Emma Bermudez, Jacqueline Hammack
Exploring Infant Toy Interactions In Free Play Environments, Emma Bermudez, Jacqueline Hammack
Florida Atlantic Undergraduate Research Journal
Infants’ interactions with toys play a crucial role in their early cognitive and motor development, yet much of the research on this topic has been conducted in controlled laboratory settings, which may not accurately reflect the diversity of toys and interactions infants experience in their natural environments. This study uniquely examined these interactions in a home setting by utilizing an online video conferencing platform. This study investigated how toy properties influence manual infant-object interactions during dyadic tabletop free play, where mothers selected the toys for the session. Within the confines of this study, results show that infants spend significantly more …
Use Of A Novel Plant Essential Oil-Based Insecticide For Insect Control In Household Gardens And Lawns, Mia Michnik, Alysa Suissa, Liah Brussolo Cremona, Annalise Wellman, Nicholas Nifakos, Alexander Spanoudis, John M. Harlin
Use Of A Novel Plant Essential Oil-Based Insecticide For Insect Control In Household Gardens And Lawns, Mia Michnik, Alysa Suissa, Liah Brussolo Cremona, Annalise Wellman, Nicholas Nifakos, Alexander Spanoudis, John M. Harlin
Florida Atlantic Undergraduate Research Journal
Insecticide use has increased as population and agricultural demand for crops grows. Commercial insecticides contain active ingredients that are often harmful to humans and the environment. A viable alternative to this concern is developing and using insecticides with low toxicity and minimum risk to the environment. In this study, we sought to empirically assess the effectiveness of an insecticide based entirely on plant essential oil active ingredients, which contain complex secondary metabolites. Our results show that a concoction of several plant essential oils was effective in killing a wide range of household garden insect species and bedbugs, encompassing five orders …
Bioarchaeological Analysis Of Three Individuals Excavated From Palikè Di Mineo, Sicily, August M. Stone, Madison Rieth, William Burnett
Bioarchaeological Analysis Of Three Individuals Excavated From Palikè Di Mineo, Sicily, August M. Stone, Madison Rieth, William Burnett
Florida Atlantic Undergraduate Research Journal
This study presents the analysis of three individuals excavated from the area of Palikè di Mineo, Sicily in May and June of 2023. The archaeological area contained numerous burials, but this study focuses on two adult male and one subadult (child). Burials are estimated to be from the Imperial Period of the Roman Empire (20 CE - 360 CE). Information collected includes age, sex, stature, and taphonomy of the individuals. Burial style, artifacts, and position of the burials are used to present data on the possible conditions of life in ancient Sicily. This article contributes data to the greater discussion …
Artist Statement, Shreyansh Patel
Artist Statement, Shreyansh Patel
Florida Atlantic Undergraduate Research Journal
No abstract provided.
Table Of Contents, Editorial Team
Table Of Contents, Editorial Team
Florida Atlantic Undergraduate Research Journal
No abstract provided.
Plant-Microbe Interactions Across Scales: Diversity, Disease, And Stress In Herbaceous Plant Communities, Philippa Tanford
Plant-Microbe Interactions Across Scales: Diversity, Disease, And Stress In Herbaceous Plant Communities, Philippa Tanford
Arts & Sciences Graduate Student Theses and Dissertations
Plants interact consequentially with microbes spanning mutualism to pathogenicity, with broader effects on large-scale plant community structure. These plant communties, in turn, shape below and aboveground microbial communities through a variety of mechanisms. However, plant diversity-microbial diversity relationships remain broadly inconsistent across environments and among different plant and microbial assemblages. In my dissertation, I work to bridge some of these gaps in plant-microbial ecology in three experimental chapters assessing relationships between plant diversity and microbial diversity, including the influence of belowground-aboveground microbiome interactions, the influence of drought stress, and incorporating different spatial and experimental scales. First, I explore the microbial …