Digital Commons Network^™

Risk Of Major Depression In Partners Of People With Alzheimer's Disease: A National Cohort Study, Casey Crump, Jingkai Wei, Barbara G Vickrey, Alexis C Edwards, Paul E Schulz, Weiva Sieh, Jan Sundquist, Kristina Sundquist

Faculty, Staff and Student Publications

Background: Alzheimer's disease (AD) may cause significant psychosocial distress not only in the patient but also their partner. However, long-term risks of major depression in partners of AD patients are largely unknown.

Methods: A national cohort study was conducted of all 145 289 partners of people diagnosed with all-cause dementia, including 57 113 partners of people diagnosed with AD, in Sweden during 1998-2017, and 1 300 561 population-based controls. Cox regression was used to compute hazard ratios (HRs) for subsequent risk of major depression identified from nationwide outpatient and inpatient diagnoses through 2018, adjusting for sociodemographic factors and prior mental …

Adults With Learning Disabilities Navigating The Transition From School To Work, Shatrece L. Jenkins

Doctoral Dissertations and Projects

The purpose of this qualitative case study was to explore the experiences of adults with learning disabilities when transitioning from academics to the workplace, with an emphasis on emotional intelligence. The two research questions asked how adults with learning disabilities described their lived experiences and experiences of emotions and emotional regulation in their transition from academic environments to the professional workplace. The theory guiding this study was the emotional intelligence theory developed by Salovey and Mayer, which was used as a determinant in building relationships and upholding social interactions. The sample consisted of 13 adults with learning disabilities working at …

Biddle Physical Ability Test (Bpat) Performance By Attempt In Southern California Structural Firefighter Candidates, Robert G. Lockie, Joseph Dulla, Jennifer Meloni, Kristina A. Ross, Robin (Rob) Marc Orr, J. Jay Dawes, Tomas J. Ruvalcaba

International Journal of Exercise Science

International Journal of Exercise Science 18(8): 895-909, 2025. The Biddle Physical Ability Test (BPAT) is a job task simulation that must be completed in ≤9:34 min:s by structural firefighter candidates to be accepted to a fire training academy. This study investigated the influence of prior attempts on BPAT time. Retrospective analysis was conducted on 1435 male and 72 female candidates. All participants received equivalent instruction on how to complete the BPAT which incorporated: dry hose drag; charged hose drag; halyard raise; roof walk; attic crawl; roof ventilation; victim removal; ladder removal and carry; stair climb with hose bundle; crawling search; …

Nadph Oxidase Isoforms (Nox-2 And Nox-4) In Myocardial Ischemia/Reperfusion Injury: Platelet Rich Plasma (Prp) As A Therapeutic Agent, Barbara Y. Hargrave, Frank Lattanzio

Cardiovascular Research Symposium

Introduction: Blood flow restoration to ischemic cardiac tissue is a critical and necessary intervention that has an associated downside: reperfusion injury. Reperfusion injury is a complicated process mediated in part by a pathological increase in reactive oxygen species (ROS). Although extremely elevated levels of ROS can cause cell damage, a minimum level of ROS is necessary for activation of Hydroxylated-HIF-1a (HIF-1a) and inhibition of Peroxisome Proliferator-Activated Receptor-alpha (PPARa) during myocardial ischemic reperfusion injury (MIRI). MIRI clinical manifestations include arrhythmias, myocardial stunning, decreased ventricular contractility and no-reflow. Platelet rich plasma (PRP) has improved left ventricular (LV) function after MIRI in …

Structural And Functional Effects Of Combination Complement And Hypothermia Therapies In A Rat Model Of Hie, Angie Saadat

Cardiovascular Research Symposium

Structural and Functional Effects of Combination Complement and Hypothermia Therapies in a Rat Model of HIE

Angela Saadat^a,b,c, Haree Pallera^b,d, Frank Lattanzio^e, Richard A. Britten^f,g, Asna Sulaiman^d, Stephanie Newman^d, Tushar Shah^a,b,c,d

^aPediatrics, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, VA, USA. ^bNeonatal Brain Institute, ^cChildren’s Specialty Group, Norfolk, VA, USA. ^dChildren’s Hospital of the King’s Daughters, Norfolk, VA, ^eDepartment of Biomedical and Translational Sciences, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, VA, …

Abundance And Demography Of The Wood Turtle (Glyptemys Insculpta) Across Two River Systems In Michigan’S Lower Peninsula, Marianne Kelso

Masters Theses

Turtles worldwide are declining from habitat loss and fragmentation, predation, and illegal collection, and their slow life histories and sensitivity to environmental change make reliable abundance and demographic data critical for conservation. Wood turtles (Glyptemys insculpta) are declining across much of their range, yet baseline information is lacking in Michigan’s Lower Peninsula. To fill that gap, we performed standardized visual mark–recapture surveys at 27 one-kilometer river reaches in two distinct watershed systems during springs of 2022 and 2023. Using hierarchical N-mixture models with negative binomial mixtures to account for imperfect detection, we estimated site-level latent abundance and evaluated …

Dna Double-Stranded Breaks, A Hallmark Of Aging, Defined At The Nucleotide Resolution, Are Increased And Associated With Transcription In The Cardiac Myocytes In Lmna-Cardiomyopathy, Benjamin Cathcart, Sirisha M Cheedipudi, Leila Rouhi, Zhongming Zhao, Priyatansh Gurha, Ali J Marian

Faculty, Staff and Student Publications

Aims: An intrinsic feature of gene transcription is the formation of DNA superhelices near the transcription bubble, which are resolved upon induction of transient double-stranded breaks (DSBs) by topoisomerases. Unrepaired DSBs are pathogenic as they lead to cell cycle arrest, senescence, inflammation, and organ dysfunction. We posit that DSBs would be more prevalent at the genomic sites that are associated with gene expression. The objectives were to identify and characterize genome-wide DSBs at the nucleotide resolution and determine the association of DSBs with transcription in cardiac myocytes.

Methods and results: We identified the genome-wide DSBs in ∼1 million cardiac myocytes …

Dairy And Food Science Student Newsletter, August 28, 2025, Department Of Dairy And Food Science

Dairy and Food Science Student Newsletter

No abstract provided.

An Antioxidant Approach To Ameliorate The Effects Of Radiation And Chemotherapy On Cognition, Raymond Anan Otoo

Theses and Dissertations

Acute Lymphoblastic Leukemia (ALL) is a hematologic malignancy that primarily affects children and young adults. While advancements in treatment—including chemotherapy and cranial irradiation—have significantly improved 5-year survival rates in children to nearly 90%, radiation-induced cognitive impairment (RICI) remains a persistent and debilitating side effect. The brain, particularly the hippocampus, is highly susceptible to radiation-induced oxidative stress and inflammation. In the treatment of ALL, the combined use of chemotherapy and radiotherapy contributes to a heightened oxidative burden, exacerbating the risk of cognitive dysfunction. Although previous studies have linked radiation exposure to neurocognitive decline, the molecular mechanisms underlying RICI and chemotherapy-induced cognitive …

Adams Contribute To Triple Negative Breast Cancer Via Mtorc1 Pathway: Targeting Adam-Mtor Axis Improves Efficacy, Shuying Liu, Huiqin Chen, Mihai Gagea, Lorenzo Federico, Fan Zhang, Javier Gomez, Kim-Anh Do, William F Symmans, Gabriel N Hortobagyi, Gordon B Mills, Ana M Gonzalez-Angulo, Debasish Tripathy

Faculty, Staff and Student Publications

Breast cancer is the most frequently diagnosed cancer globally and the second leading cause of cancer-related deaths in American women. Triple-negative breast cancer (TNBC) lacks estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. Thus, fewer targeting therapies are available for this most aggressive subtype. The A Disintegrin and Metalloproteinase (ADAM) family plays a vital role in cancer pathophysiology. Previous studies focused on single ADAM members. However, none of these have entered into the clinical arena as diagnostics or therapeutics for breast cancer. In this study, we demonstrate the upregulation of a panel of ADAM members in TNBC, …

The Immunophenotypic And Genetic Characterization Of Pediatric T -L Ymphoblastic Leukemia With A Mature Immunophenotype, Mahsa Khanlari, Wei Wang, Parastou Tizro, Mohammad K Eldomery

Faculty, Staff and Student Publications

Not available.

Alterations In Ether Lipid Metabolism In Obesity Revealed By Systems Genomics Of Multi-Omics Datasets, Yvette Schooneveldt, Sudip Paul, Kevin Huynh, Habtamu B. Beyene, Natalie A. Mellett, Gerald F. Watts, Joseph Hung, Jennie Hui, John Beilby, John Blangero

Human Genetics Publications

Ratios between two metabolites are sensitive indicators of metabolic changes. Lipidomic profiling studies have revealed that plasma ether lipids, a class of glycero- and glycerophospho-lipids with reported health benefits, are negatively associated with obesity. Here, we utilized lipid ratios as surrogate markers of lipid metabolism to explore the processes underlying the inverse relationship between ether lipid metabolism and obesity. Plasma lipidomics data from two independent human cohorts (n = 10,339 and n = 4,492) were integrated to assess the associations between 82 lipid ratios and obesity-related markers in males and females. Results were externally validated using mouse transcriptomics data …

Rna Sequencing-Based Transcriptome Analysis Of Liver In Laying Hens Supplemented With Dietary Probiotic Bacillus Species And Prebiotic Yeast (Saccharomyces Cerevisiae) Cell Walls, Ala E. Abudabos, Zafar M. Hakami, Ali R. Al Sulaiman, Riyadh S. Aljumaah, Valentino Palombo, Mashael R. Aljumaah, Mariasilvia D’Andrea, Abdulrahman S. Alharthi, Rashed A. Alhotan

Food and Animal Sciences Faculty Research

To investigate the impacts of dietary Bacillus-based probiotics and yeast-derived prebiotics on the hepatic transcriptome profile, 500 Hisex White laying hens were randomly allotted into five dietary treatments from 37 to 52 weeks of age: control; control + Bacillus subtilis; control + Bacillus subtilis and Bacillus licheniformis; control + Bacillus coagulans; and control + Saccharomyces cerevisiae yeast cell wall. Transcriptome analysis revealed a substantial number of differentially expressed genes exclusively between the control and prebiotic groups, identifying 2221 genes (FDR ≤ 0.05), with 980 genes upregulated (log2 fold change 0.69 to 24.62) and 1241 downregulated (log2 fold change −0.74 to …

The Illusion Of Internal Models In Biological Movement, Madhur Mangalam

Journal Articles

The concept of internal models dominates contemporary theories of sensorimotor control, with researchers across neurosciences, specifically motor control, routinely explaining observed behaviors through computational representations that supposedly exist within the nervous system. In this perspective, I present a critical examination of internal model frameworks in sensorimotor control. I argue that representational approaches mischaracterize biological systems for several fundamental reasons: (1) Internal models require homuncular interpreters, creating infinite regress problems; (2) The purported neural implementations of internal models remain empirically elusive despite decades of research; (3) Biological movement systems exhibit multiscale, nonlinear, and non-Gaussian dynamics that fundamentally defy reduction to conventional …

An Economic Assessment Of Precision Conservation With On-Farm Precision Experiment Data, Karina A. Schoengold, Badri Khanal, Taro Mieno, David S. Bullock

Cornhusker Economics

Using a novel dataset that includes within field variation in productivity, we find that partial field retirement for a prairie strip can not only provide conservation benefits, but can also be economically beneficial. We note that these results are for a single field with one year of data, and that additional years of production and fields are essential to determine how much these results can be generalized. We also note that precision systems can be costly, and a comparison of outcomes with and without this information is essential to determine if investing in such systems is profitable. However, variable rate …

Modulating Treatment Outcomes Of Patients With Solid Tumors In Immunotherapy Trials: A Drug Interaction Analysis From A Phase 1 Unit, Camila Braganca Xavier, Clark R Andersen, Joann Lim, Julian H Slade, Stacie A Bean, Lei Kang, Hung Le, Apostolia M Tsimberidou, Aung Naing, David S Hong, Ecaterina E Dumbrava, Jordi Rodon Ahnert, Paula R Pohlmann, Sarina A Piha-Paul, Stephane Champiat, Timothy A Yap, Tin-Yun Tang, Funda Meric-Bernstam, Siqing Fu

Faculty, Staff and Student Publications

Concurrent use of medications can modulate the effectiveness of immunotherapy. Although this interaction is well documented for immune checkpoint inhibitors, whether this occurs with new experimental compounds has not been evaluated. A computerized data extraction tool was used to collect clinical data and identify the prescription of a predefined set of medications within 30 days of immunotherapy infusion in the Department of Investigational Cancer Therapeutics at The University of Texas MD Anderson Cancer Center. The primary endpoints were median overall survival (OS) and progression-free survival. Tumor responses were addressed using RECIST. We identified 897 patients. The most prevalent tumor types …

Antibiogram Development For Neonatal Intensive Care Unit In A Referral Hospital In Sana'a City, Yemen, Mohammed A. Kubas, Massoud K. Rassam, Amaal A. Alsayani

AUIQ Complementary Biological System

Neonates have an immature immune system, making them highly susceptible to infections. Treatment failure in newborns may result from antibiotic resistance, a significant challenge in the management of infectious illnesses worldwide. So the main objective of this research was to develop a newborn-specific antibiogram at the University of Science and Technology hospital (USTH) in Sana’a, Yemen. A retrospective analysis was conducted using microbiological data from the USTH database during the period from January 2021 to March 2022, antibiogram was generated and analyzed using the WHONET application. Gram-positive bacteria were the most frequently isolated pathogens in neonates, followed by gram-negative bacteria. …

Biosorption Of Crystal Violet Onto Fenugreek Seed Powder: Comprehensive Optimization Through Response Surface Methodology And Elucidation Of Dye Uptake Mechanism, Hasan M. Agha, Zaher Mundher Yaseen, Wafaa Raji Alfatlawi, Khansaa Al-Essa, Abdallah Reghioua, Hussein A. Kazem, Lee D. Wilson

AUIQ Complementary Biological System

This work investigates the efficacy of fenugreek seed powder (FSP), an agricultural product, as an economical and sustainable biosorbent for the extraction of crystal violet (CV) dye from aqueous environments. The biosorbent was analyzed using XRD, FTIR, and SEM-EDX, validating its amorphous structure, surface functional groups, and porous shape. Batch biosorption tests were adjusted utilizing a Box–Behnken design (BBD), incorporating three independent variables: FSP dose (0.02–0.1 g/100 mL), pH (4–10), and time (5–60 min). The model exhibited exceptional prediction accuracy (R² = 0.99, CV = 2.12%) and recognized all three variables as statistically significant (p < 0.05). The maximum CV removal attained was 91.8% efficiency at an FSP dose of 0.1 g/100 mL, pH 7, and a time of 60 minutes. FTIR examination indicated changes in the –OH, C=O, and C–O functional groups, signifying their participation in dye interaction, whilst SEM pictures validated dye deposition on the biosorbent surface. The biosorption process was ascribed to electrostatic forces, hydrogen bonding, π–π stacking, and pore filling. These findings underscore FSP as a viable, economical biosorbent for the removal of cationic dyes in wastewater treatment applications.

Mollusks From Crusader-Period ‘Akko, The Knights’ Hotel Site, Inbar Ktalav

'Atiqot

This study analyzes mollusk remains collected during the 2007 excavation season at the Knights’ Hotel site in ‘Akko, which was part of a Crusader-period residential neighborhood. A total of 538 shells were identified, including marine shells from the Mediterranean and Red Seas, freshwater shells and land snails. The analysis of these shells sheds light on the lives of the Crusader-period residents of ‘Akko, including their trade connections and use of shells for construction, ornamentation, pigment containers and raw material for the inlay industry.

Fragments Of A Crusader-Period Chancel Screen From ‘Akko, The Knights’ Hotel Site, Vardit R. Shotten-Hallel

'Atiqot

The phrase ‘where [or: when] least expected’ is rarely used in archaeology. In fact, when excavating a cesspit, the opposite is often true. Cesspits are precisely where archaeologists expect to uncover hoards of household artifacts, like pottery and glass, or sometimes valuables, dislocated sculptures and even skeletons. In this regard, the excavation at the Knights’ Hotel site in ‘Akko is no exception. Four richly decorated marble fragments were found in a cesspit, integrated in the shaft’s wall as part of repair work. A stylistic analysis, and consideration of the historical context of their deposition, revealed an unexpected possibility regarding their …

The Metal Finds From ‘Akko, The Knights’ Hotel Site, Joppe Gosker

'Atiqot

The 2007 excavation at the Knights Hotel Site yielded about 170 metal finds, mostly iron or copper alloy, though silver and gilded items were also found. Some objects associated with warfare may have been linked to the final battle of ‘Akko in 1291 CE, but most of the finds relate to daily life, encompassing activities such as horse keeping, dress, foodways, medicine and construction. The dominance of Eastern-type arrowheads indicates that local traditions were sometimes adopted, certainly for the arrows if not the bows. Concerning dress accessories, the overall impression is of European traditions. It seems that the Franks preferred …

Stone Objects From ‘Akko, The Knights’ Hotel Site, Anastasia Shapiro

'Atiqot

Four stone objects were retrieved during the 2007 excavation season at the Knights’ Hotel site: three whetstones and one bead. Besides the routine registration of measurements and visual description, the specimens were examined under a binocular microscope at ×20 and ×40 magnifications, with the aid of 5% dilute hydrochloric acid and a steel needle. This procedure made it possible to define the lithology of the rock that the objects were made of and to trace use features like minor scratches, which usually receive little attention.

Crusader-Period Glass Finds From ‘Akko, The Knights’ Hotel Site, Yael Gorin-Rosen

'Atiqot

This article discusses the glass finds uncovered during the 2007 excavation season at the Knights’ Hotel site and complements the report of the 1995 season. This collection of glass vessels is significant as it expands our knowledge concerning the variety of types produced in the local workshops and includes a variety of vessels from other production centers. Together, the finds from both seasons emphasize the richness and diversity of Crusader-period glassware and artifacts during the thirteenth century, before the fall of ‘Akko in 1291.

Tobacco Pipes From ‘Akko, The Knights’ Hotel Site, Anastasia Shapiro

'Atiqot

The study of 111 Ottoman tobacco pipes and three nargile heads from the excavation of the Knights’ Hotel site in ‘Akko illuminates the smoking habits of the population of this quarter of the city between the early seventeenth and mid-nineteenth centuries. The dates, provenance and typology of the pipes are based on the results of previous studies. The latest date of most of the pipes in this corpus may be related to an explosion during the siege of 1840, after which the quarter remained unoccupied.

Petrographic And Microscopic Examination Of Crusader-Period Pottery From ‘Akko, The Knights’ Hotel Site, Anastasia Shapiro

'Atiqot

A petrographic and microscopic study was undertaken for 14 Crusader-period vessels from the Knight’ Hotel site in ‘Akko. The petrographic analysis confirmed the presumed Egyptian origin of twelve vessels, while the microscopic examination of two pithoi suggested that their raw material originated within an ophiolitic complex found in Venice and its vicinity.

Crusader-Period Ceramics From The Knights’ Hotel Site, ‘Akko, Edna J. Stern, Nohar Shahar

'Atiqot

The Crusader-period ceramic assemblage unearthed in the Knights’ Hotel site in ‘Akko contains a large variety of daily wares. The assemblage consists of local and imported wares from various regions, some of which were identified through petrographic analysis. The imported wares indicate trade connections with Mediterranean port cities, and the petrographic analysis identified a new group of vessels from Egypt’s northern Nile region. The article outlines the pottery typology and quantification, and presents the ceramic distribution within the excavated urban area. The findings indicate changes in land use, as some residential and commercial areas were converted into dumps and cesspits. …

Daily Life And Industry In Crusader ‘Akko: The Knights’ Hotel Site, Danny Syon

'Atiqot

This report details the second season of excavations at the Knights’ Hotel site, carried out in 2007, covering three areas (A–C) not excavated in the first season (1995). The excavations revealed domestic and public(?) architecture dating from the thirteenth century CE. The architectural features are mostly similar to the ones exposed in the first season and include an abundance of water and sanitary installations: cisterns, wells and cesspits. The mixed character of this neighborhood of the capital of the Crusader kingdom of Jerusalem, and the daily life of its residents is highlighted by the wealth of pottery and glass vessels …

Remains Of Two Iron Age Iib–C(?) Updraft Pottery Kilns At The Foot Of Tel Gamma (Tell Jemma), Davida Eisenberg-Degen, Ilana Peters, Svetlana Talis, Yael Abadi-Reiss, Emily Bischoff Bruintjes, Yotam Asscher

'Atiqot

An excavation southwest of Tel Gamma exposed two Iron Age II updraft pottery kilns and a refuse pit. The eastern kiln was only partially preserved; its fill contained workshop debris and storage-jar wasters. The better-preserved western kiln retained an almost intact, elongated combustion chamber with two sets of mud-brick flues and evidence of periodic upkeep. An activity layer was identified between and around the kilns, from which a mixed Iron IIA–C ceramic assemblage and a few stone artifacts were collected. The stone artifacts likely served in fine grinding and burnishing. In the refuse pit, potsherds, vitrified bricks, animal bones and …

A Middle Bronze Iia Pottery Production Site On The Northern Bank Of NaḥAl Soreq, Near Yavne-Yam, Lily Singer-Avitz, Yossi Levy, Etan Ayalon

'Atiqot

A Middle Bronze Age IIA pottery production site was uncovered on the northern bank of Naḥal Soreq, near Yavne-Yam. Excavations revealed installations, including pits, an oven, a stone pavement and a two-story pottery kiln. The discovery of a potter’s wheel and petrographic analysis confirm local ceramic production using nearby ḥamra and kurkar materials. Stone anchors found on-site suggest the transport of vessels via small boats along the stream, connecting the site with nearby settlements such as Nabi Rubin and Yavne-Yam.

Middle Bronze Age Human Skeletal Remains From Nahal Rimmonim, Yossi Nagar

'Atiqot

The excavation at Nahal Rimmonim yielded the remains of seven individuals interred in jar burials and a grave dating, respectively, to Middle Bronze Age I–II and III. The MB I–II storage-jar burials were uncovered in a residential area, comprising three infants—a well-documented trait of the period. The MB III remains include the primary burial of four individuals in stone-built graves: three adults and a child aged three–four years.