Digital Commons Network^™

Lesion Absorbed Dose-Response Relationship In Patients With Metastatic Castration-Resistant Prostate Cancer Undergoing [177lu]Lu-Psma-617 Radiopharmaceutical Therapy, Milan Grkovski, Simone S Krebs, Joseph A O'Donoghue, Jonathan Kuten, Audrey Mauguen, Parnian Shobeiri, Daniel Lafontaine, Maria Thor, Finn Augensen, Josef J Fox, Neeta Pandit-Taskar, Mark P Dunphy, Lisa Bodei, John L Humm, Heiko Schöder

Faculty, Staff and Student Publications

The relationship between lesion absorbed dose (AD) and response in patients with metastatic castration-resistant prostate cancer undergoing [177Lu]Lu-PSMA-617 radiopharmaceutical therapy (RPT) remains poorly understood. The objective of this work was to investigate the AD-response relationship at both the patient and lesion levels.

Methods: Sixty-five patients underwent serial SPECT/CT imaging after receiving 7.31 ± 0.27 GBq of [177Lu]Lu-PSMA-617. Single-time-point (STP) (Hänscheid approximation at 72 h) and multiple-time-point voxelwise dosimetry were performed. Patient response was evaluated by changes in serum prostate-specific antigen level before and after cycle 1 of RPT. The response of individual lesions was evaluated by the change in the …

From Nociception In Aneural Animals To Human Suffering: Toward A Comparative Biology Of Pain, Edgar T Walters

Faculty, Staff and Student Publications

Pain is a core feature of human life, but systematic comparisons of this biological trait across taxa have been rare. A broadly accepted definition based on human experience emphasizes dual features of pain: a sensory (discriminative) component for sensing and monitoring tissue injury, and an affective (emotional) component to motivate avoidance of tissue distress. Conscious pain is coupled to unconscious nociception (detection of incipient or existing injury). This Review considers nociception and pain across phyla within a comparative framework, addressing basic questions about evolutionary origins, mechanisms and functions of pain. The occurrence of adaptive cellular responses to injury in virtually …

Epigenetic Age Acceleration Mediates Treatment Effects On Cardiometabolic And Cardiovascular Risk In Childhood Cancer Survivors, Xiaoxi Meng, Tiffany Eulalio, Yoonji Kim, John Easton, Heather L Mulder, Emily Walker, Geoffrey Neale, Nan Song, Kyla Shelton, Rebecca M Howell, Mengqi Xing, Sedigheh Mirzaei, Deo Kumar Srivastava, Bonnie Ky, Stephanie B Dixon, Melissa M Hudson, Kirsten K Ness, Gregory T Armstrong, Zhaoming Wang

Faculty, Staff and Student Publications

BACKGROUND: Childhood cancer survivors are at increased risk for epigenetic age acceleration (EAA) and subsequent morbidities, including cardiometabolic risk factors (CMRFs) and cardiovascular diseases, because of prior genotoxic treatments.

OBJECTIVES: The aim of this study was to evaluate the mediating role of EAA in the relationship between cancer treatment exposures and risk for CMRFs and cardiovascular diseases.

METHODS: This study included 2,939 5-year survivors from SJLIFE (St. Jude Lifetime Cohort) who underwent DNA methylation profiling using peripheral blood mononuclear cells. EAA was calculated using 3 established epigenetic clocks: DunedinPACE, PCPhenoAge, and GrimAge2. Treatment data, including body region-specific radiotherapy (RT) and …

A Phase 2 Study Of Cpx-351 In Combination With Venetoclax In Patients With Newly Diagnosed High-Risk Acute Myeloid Leukemia, Wei-Ying Jen, Jennifer Croden, Emmanuel Almanza-Huante, Courtney Dinardo, Kelly Chien, Danielle Hammond, Wei Qiao, Yesid Alvarado, Lucia Masarova, Andres E Quesada, Sherry Pierce, Alex Bataller, Guillermo Garcia-Manero, Amin Alousi, Nicholas Short, Naval Daver, Farhad Ravandi, Hagop Kantarjian, Tapan M Kadia

Faculty, Staff and Student Publications

Venetoclax has been combined with intensive chemotherapy regimens in the treatment of acute myeloid leukemia (AML). We aimed to investigate the safety and efficacy of venetoclax combined with full‐dose CPX‐351 (CPX + VEN) in newly diagnosed (ND) AML. Seventeen patients with a median age of 59 years (range, 43–69) were treated; 71% had secondary AML, 47% had prior hypomethylating agent (HMA) exposure, 59% had myelodysplastic syndrome (MDS)‐related (MR) mutations, 47% had complex karyotype, and 29% were TP53 mutated. The overall response rate (ORR) was 82% (95% CI, 57–96) with a composite complete remission rate (CRc) of 71% (95% CI, 50–93). …

Hooks For Four-Dimensional Ecology Education (4dee) Teaching With Differing Audiences Of Nonmajors, Sara E. Scanga, Vikki L. Rodgers, Loren B. Byrne, Justin R. St. Juliana, Jon M. Honea, Erica S. Tietjen, George Middendorf

Arts & Sciences Faculty Publications

Nonmajors (i.e., undergraduate students not majoring in the natural sciences) constitute a majority of United States college graduates and are a large potential audience for courses with ecology content. However, nonmajors may be unmotivated to learn about ecology because they perceive it to be uninteresting and irrelevant to their everyday lives or career goals. Although the Four-Dimensional Ecology Education (4DEE) framework can be adapted for nonmajors courses as a starting point to improve student engagement, we suggest that nonmajors ecology instructors also use ecology hooks as effective gateways to 4DEE that will motivate and deepen student learning. Selecting and developing …

Multi-Institution Analysis Of Tarlatamab For The Treatment Of Egfr-Mutant Transformed Small Cell Lung Cancer, Alissa J Cooper, Benjamin Herzberg, Mitchell Parma, Kaiwen Wang, Laura Alder, Urs M Weber, Tejas Patil, Utsav Joshi, Sonam Puri, Anjali Saqi, Phoebe Clark, Carl M Gay, Tina Cascone, Eric K Singhi, George Blumenschein, Ferdinandos Skoulidis, Janet Tu, Thomas E Stinchcombe, Charles M Rudin, Catherine A Shu, Lauren A Byers, Helena Yu, Bingnan Zhang

Faculty, Staff and Student Publications

No abstract provided.

Pka-Driven Spp1 Activation As A Novel Mechanism Connecting The Bone Microenvironment To Prostate Cancer Progression, Pablo Sanchis, Agustina Sabater, Julia Lechuga, Jimena Rada, Rocio Seniuk, Gaston Pascual, Mora Gatti, Juan Bizzotto, Peter D A Shepherd, Jun Yang, Javier Cotignola, Elba Vazquez, Joaquin Mateo, Pia Valacco, Estefania Labanca, Christopher Logothetis, Geraldine Gueron, Nicolas Anselmino

Faculty, Staff and Student Publications

Prostate cancer (PCa) bone metastasis (BM) poses a significant clinical challenge due to the heterogeneity of treatment responses and patient outcomes. In this study, we examined the role of Protein Kinase A (PKA) signaling in modulating the expression of osteopontin (SPP1/OPN), a protein associated with poor prognosis, within a subset of PCa BM patients. By integrating multi-omics results we identified a novel mechanism in which bone-derived type-I collagen (Col1a1) and fibronectin (Fn1) stimulate SPP1 expression in PCa cells through the activation of PKA signaling. This bone-induced regulation of SPP1 was confirmed both in vitro, using PCa-bone co-culture systems (PC3 or …

Alterations In Region-Specific Gray Matter Volume Underlying Callous Unemotional Traits In Adolescents, Johannah Bashford-Largo, Ru Zhang, R James R Blair, Karina S Blair, Jaimie Elowsky, Matthew Dobbertin, Ahria J Dominguez, Melissa Hatch, Tyler Patrick, Sahil Bajaj

Faculty, Staff and Student Publications

Background: Callous-unemotional (CU) traits during adolescence, for example, shallow affect or lack of remorse, have been shown to be a risk marker for antisocial behavior. Only a few studies have investigated structural brain alterations underlying CU traits, and findings are inconclusive. The study examines CU symptomatology and gray matter volume (GMV) associations.

Methods: Structural brain MRI data were collected from a sample of 578 adolescents (60% male) with a mean age of 14.85 years (SD = 2.30; range = 10-19 years). CU traits were indexed via the Inventory for Callous Unemotional Traits (ICU). Region-wise volumetric parameters were obtained following parcellation …

Outcomes Of Adult Patients With Newly Diagnosed Idh-Mutated Aml Treated With Intensive Chemotherapy And Venetoclax, Jennifer Croden, Wei-Ying Jen, Jennifer Marvin-Peek, Lianchun Xiao, Ian M Bouligny, Sanam Loghavi, Gautam Borthakur, Naval G Daver, Hussein A Abbas, Koichi Takahashi, Koji Sasaki, Naveen Pemmaraju, Nicholas J Short, Danielle Hammond, Elias Jabbour, Lucia Masarova, Kelly S Chien, Ghayas C Issa, Guillermo Montalban-Bravo, Musa Yilmaz, Abhishek Maiti, Yesid Alvarado-Valero, Guillermo Garcia-Manero, Farhad Ravandi, Marina Y Konopleva, Hagop M Kantarjian, Tapan M Kadia, Courtney D Dinardo

Faculty, Staff and Student Publications

No abstract provided.

Investigating The Effect Of Gene Ncu07872 Deletion On Spore Killing By Neurospora Sk-3, Allison Rimmey

Senior Theses – Biological Sciences

The selfish genetic element Spore killer-3 (Sk-3) is found in some Neurospora fungi. Sk-3 is considered selfish because it has evolved the capacity to bias its transmission to the next generation through spore killing. The mechanism of spore killing requires at least two genes, a gene that produces a resistance protein (an antidote) and a gene that produces a killer protein (a poison). The Sk-3 genetic element is millions of base pairs long and contains hundreds of genes. Although the antidote gene has been identified, the identity of the poison gene has remained elusive. Previous research has identified a DNA …

Understanding Animal Introductions And Welfare In Zoos: A Scoping Review, Claudia C. Martinez, Valerie James-Aldridge, Todd J. Mcwhorter, Eduardo J. Fernandez

Psychological Science Faculty Publications

Managing captive zoo species often requires modifying their social groups, but these changes can increase stress and aggression. Specifically, introductions of new animals to existing exhibits with established animals is commonplace, yet little has been published to systematically evaluate this process. This review used the PRISMA framework to evaluate published research on introductions of unfamiliar individuals in zoos, aquariums, and sanctuaries. Peer-reviewed studies from PubMed, Web of Science, and Scopus were screened and extracted using Covidence software. Studies were included if they provided quantitative data and before-and-after comparisons. Of 25 studies meeting criteria, most focused on primates, especially western lowland …

Penetrance Of Neurodevelopmental Copy Number Variants Is Associated With Variations In Cortical Morphology, Ana I. Silva, Ida E. Sønderby, George Kirov, Abdel Abdellaoui, Ingrid Agartz, David Ames, Nicola J. Armstrong, Eric Artiges, Tobias Banaschewski, John Blangero

Human Genetics Publications

Background: Copy number variants (CNVs) may increase the risk for neurodevelopmental conditions. The neurobiological mechanisms that link these high-risk genetic variants to clinical phenotypes are largely unknown. An important question is whether brain abnormalities in individuals who carry CNVs are associated with their degree of penetrance.

Methods: We investigated whether increased CNV penetrance for schizophrenia and other developmental disorders was associated with variations in cortical and subcortical morphology. We pooled T1-weighted brain magnetic resonance imaging and genetic data from 22 cohorts from the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis)-CNV consortium. In the main analyses, we included 9268 individuals …

Functional Analysis Of R144 In The Flavin Oxidation Mechanism Of A Flavin-Dependent N-Monooxygenase, Reeder Robinson, Korliss Britt, Pablo Sobrado

Chemistry Faculty Research & Creative Works

Flavin-dependent N-monooxygenases (NMOs) are key enzymes in the biosynthesis of hydroxamate-containing siderophores, which are critical virulence factors in pathogenic microorganisms. SidA, an NMO from Aspergillus fumigatus, catalyzes the NADPH- and O2-dependent hydroxylation of L-ornithine (Orn) via a stable C4a-hydroperoxyflavin (FADOOH) intermediate. This study investigates the role of Arg144 in the catalytic cycle of SidA. Site-directed mutagenesis of Arg144 to alanine (R144A) significantly impaired both oxygen consumption and Orn hydroxylation, resulting in an approximately 60-fold reduction in kcat and a ~300-fold decrease in kcat/KM. The pH dependence, solvent kinetic isotope effects, and rapid-reaction kinetics reveal that R144 influences protonation events crucial …

Physicochemical And Structural Optimization Of Date (Phoenix Dactylifera L.) Syrup: Impact Of Extraction Temperatures And Pectin Addition, Afna Thaivalappil Abdul Asiz

Theses

This thesis focuses on the optimization of date (Phoenix dactylifera L.) syrup, an emerging natural sweetener rich in glucose, fructose, and bioactive compounds, by investigating how extraction temperature and pectin incorporation influence its physicochemical and structural properties. Therefore, the main objective of this study was to examine how extraction temperatures (25°C, 50°C, 75°C, and 90°C), and the incorporation of lowmethoxyl pectin (LMP, DE 31%) and high-methoxyl pectin (HMP, DE 85%) prior to concentration, affect the quality, stability, and functionality of date syrup. The results showed that increasing extraction temperatures increased the total soluble solids (16 °Brix at 25°C to …

Ecology Of Eupatorium Altissimum Galls: Extrapolating Timing Of Oviposition Using Plant Growth Curves, Tomofumi Inoue, Dana Dudle, James Benedix

Annual Student Research Poster Session

This study aims to investigate the timing of oviposition by the gall fly Neolassioptera perfoliata on tall boneset (Eupatorium altissimum) populations throughout the DePauw University Nature Park. I initially measured the heights of 176 plants total in 5 different locations, out of which I randomly selected 12-17 plants per location to measure height on a weekly basis. When galls were spotted, their heights were recorded so that they could be compared to the plant heights to produce an estimate for when the egg was laid by the gall fly. I also collected galls from plants that were excluded in the …

Cattle Funding Scheme 2023-24 Annual Report, Department Of Primary Industries And Regional Development, Western Australia

Biosecurity published reports

I am pleased to present the 2023-24 annual report for the Cattle Industry Funding Scheme (Cattle IFS) to our participants, key stakeholders in the Western Australian (WA) cattle industry, and the Minister for Agriculture and Food. This financial year has brought its share of challenges to the WA cattle industry including domestic and global markets, dry weather conditions and high biosecurity concerns. With Foot-and-mouth disease (FMD) and Lumpy Skin Disease (LSD) detected in Indonesia, biosecurity threats remain ever-present. As a result, maintaining the health of our herd in WA continues to be our top priority. The Cattle IFS continues to …

Bone Mineral Density Of Willow Ptarmigan (Lagopus Lagopus) As A Potential Taphonomic Factor In Skeletal Part Attrition, Frank J. Dirrigl Jr., Samuel R. Buchanan

School of Integrative Biological & Chemical Sciences Faculty Publications

Agents of taphonomy can bias skeletal parts and the frequency of bones in archaeological sites. An important factor to consider is the possible effect of bone density-mediated attrition on archaeornithological assemblages. We scanned willow ptarmigan (Lagopus lagopus) specimens using a Lunar iDXA and an enCcore small animal body add-on to develop a rank-order scheme based on the volumetric bone mineral density (vBMD) of skeletal parts. Our results identified the tibiotarsus and femur to be the least dense bones, while carpometacarpus, 3rd digit, and coracoid were the densest. This novel scheme allowed us to evaluate a sample of 22 …

Preliminary Investigation Of Nitrogen Rate Influence On Irrigated Bermudagrass Forage Production, Bronc Finch, Lance Blythe

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Bermudagrass (Cynodon dactylon) forage production recommendations are often developed in natural environments with available water limitations, often resulting in highly variable responses and lower average responses. As farmland ownership changes and agriculture and irrigation technologies become more affordable the amount of irrigated hay production has increased. While much of the agronomic management does not differ between rain-fed and irrigated environments, nutrient use and uptake dynamics may. This requires a reevaluation and potential adjustment of current recommendations to allow for increased yield potential of irrigated production systems without detrimental impacts on the system. The objective of this study was to identify …

Twenty-Four Year Record Reveals Increasing Discharge In Tributaries To A Key Drinking Water Resource, Shannon Speir, Ireyra G. Tamayo, Alana G. Strauss

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Climate change is altering precipitation patterns worldwide, yielding changes in streamflow and water availability. Increases in storm frequency and intensity, as well as prolonged droughts, may alter the timing and magnitude of flow and nutrient delivery to downstream systems, many of which serve as key drinking water resources. Thus, we must understand long-term changes in streamflow to protect drinking water supplies. Here, we document changes in streamflow delivery to Beaver Lake Reservoir, the key drinking water source in rapidly urbanising Northwest Arkansas. We used publicly available data to analyse flow records in four key tributaries to Beaver Lake from 2000 …

Proteomic Approaches To Investigate Pp2a-B55 Substrates And Cellular Function, Brennan C. Mcewan

Dartmouth College Ph.D Dissertations

Cell division is controlled in large part by reversible protein phosphorylation. The phosphorylation state of proteins during mitosis and other phases of the cell cycle represents a careful balance of activity between kinases and opposing phosphatases. The phosphoprotein phosphatase (PPP) family is responsible for the majority of serine and threonine dephosphorylation. Members of the PPP family are composed of a catalytic subunit paired with a regulatory subunit that targets them towards specific substrates.

The most abundant PPP, PPP2A, paired with its regulatory B55 subunit, is thought to be the phosphatase responsible for the dephosphorylation of substrates during mitotic exit. Despite …

Smart Search Results For Growth And Economic Performance Comparison Of Twenty-Year-Old ... Refine Results For Arkansas Net Energy: A Productive Energy System Sensitive To Broiler Performance And Body Composition Arkansas Net Energy: A Productive Energy System Sensitive To Broiler Performance And Body Composition 21 Of 94 Arkansas Net Energy: A Productive Energy System Sensitive To Broiler Performance And Body Composition, Diego A. Martinez, Nawin Suesuttajit, Cole Umberson, Craig N. Coon

Poultry Science Faculty Publications and Presentations

This study determined the sensitivity of productive energy (PE; Arkansas Net Energy) to performance and body composition and developed predictive models based on PE. Chicks (2,148 day-old ones) were placed in 96 pens and assigned to one of 12 dietary treatments, including varying concentrations of total digestible amino acids (TDAA), digestible CP (dCP), digestible fat (dFat), digestible starch, and non-starch polysaccharides (NSP). Eight replications per treatment, one per block, were used, being the block consecutive groups of birds weekly starting the seven-day experimental period. In each block, birds were control fed to meet similar ME intake, placed in calorimetry chambers …

Productive Energy, As Determined By Arkansas Net Energy, Predicts Broiler Processing Weights, Carcass Market Value, And Gross Profit, Diego A. Martinez, Nawin Suesuttajit, Cole Umberson, Craig N. Coon

Poultry Science Faculty Publications and Presentations

This study assessed the sensitivity of Productive Energy (PE) to breast meat production, feed efficiency, and broiler economics, developed models for processing traits and economics, and examined economics dynamics. The experimental design involved 96 pens, 12 per block and eight blocks, with each pen within block receiving one of 12 dietary treatments for one week. Treatment diets, varying in amino acid concentrations, starch, and energy densities, were control-fed. The weights of processing body parts and net energy for gain (NEg) were determined with Dual-Energy X-Ray Absorptiometry, and fed heat production, fasting heat production (FHP), and net energy for maintenance (NEm) …

Effects Of Heat Stress And Depressed Feed Intake On The Cecal And Ileal Microbiota Of Broiler Chickens, Philip M. Campos, Elizabeth S. Greene, Monika Proszkowiec-Weglarz, Sami Dridi

Poultry Science Faculty Publications and Presentations

Chronic heat stress (HS) is known to depress feed intake (FI) and growth in broiler chickens, and may alter the gut microbiota and health, however, the amplitude and duration of each (HS and depressed FI) effect on gut microbiota is still unclear. This study aimed to determine the effects of chronic and acute HS on the cecal and ileal microbiota profiles. Broilers were subjected to thermoneutral (TN, 23 degrees C) or chronic cyclic HS (CHS, 8 h/d, 35 degrees C) condition from d29-42, and one group to acute HS (AHS, 2 h, 35 degrees C) at d42. To distinguish between …

Integrating Food Loss And Waste Reduction Policies With Global Dietary Shifts: An Economic Modelling Study, Alessandro Gatto, Maksym Chepeliev

Department of Agricultural Economics Faculty Publications

Background

Methods

Cul3 Postnatal Homozygous Deletion In Forebrain Results In Behavioral Differences, Prathibha Sekar, Qiang‐Qiang Xia, Alex C. Stokes, Feiyu Quan, Jeffrey Singer, Craig M. Powell

Biology Faculty Publications and Presentations

Large-scale human genetic studies implicate multiple genes that regulate protein ubiquitination in autism spectrum disorder (ASD). De novo loss-of-function mutations in the gene CULLIN3 (CUL3) are implicated in autism and intellectual disability (ID). CUL3 is an essential component of an E3 ubiquitin ligase complex required for ubiquitination of substrates, often a signal for proteasomal degradation. Homozygous deletion of Cul3 is embryonically lethal. Recent studies show heterozygous deletion of Cul3 results in phenotypes with some face validity for autism in constitutive and conditional Cul3 heterozygotes. To understand the function of Cul3 in late postnatal development and function in the brain, we …

Dynamic Rewiring Of Microrna Networks In The Brainstem Autonomic Control Circuits During Hypertension Development In The Female Spontaneously Hypertensive Rat, Alison Moss, Ankita Srivastava, Lakshmi Kuttippurathu, James S. Schwaber, Rajanikanth Vadigepalli

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

We describe global microRNA (miRNA) changes in the central autonomic control circuits during the development of neurogenic hypertension. Using the female spontaneously hypertensive rat (SHR) and the normotensive Wistar Kyoto (WKY), we analyzed the dynamic miRNA expression changes in three brainstem regions-the nucleus of the solitary tract, caudal ventrolateral medulla, and rostral ventrolateral medulla-as a time series beginning at 8 wk of age before hypertension onset through to extended chronic hypertension. Our analysis yielded nine miRNAs that were significantly differentially regulated in all three regions between SHR and WKY over time. We collated computationally predicted gene targets of these nine …

Integrating Multimodal Neuroimaging Of Error Monitoring To Estimate Future Anxiety In Adolescents, Emilio A. Valadez, Stefania Conte, John E. Richards, Yi Feng, Lucrezia Liuzzi, Marco Mcsweeney, Enda Tan, George A. Buzzell, Anderson M. Winkler, Daniel Samuel Pine

Human Genetics Publications

Importance Anxiety disorders are highly prevalent and associated with heightened error monitoring, the detection of one’s mistakes. However, error monitoring, anxiety, and their associations change throughout adolescence, limiting the ability to estimate future anxiety trajectories during this period.

Objective To ascertain whether measures of error monitoring obtained via the integration of electroencephalogram (EEG) and functional magnetic resonance imaging (fMRI) improve estimations of future anxiety compared with EEG or fMRI alone, in adolescents with or without a history of behaviorally inhibited temperament.

Design, Setting, and Participants This longitudinal cohort study was conducted at a university research laboratory and government research hospital. …

Picalm Alzheimer’S Risk Allele Causes Aberrant Lipid Droplets In Microglia, Alena Kozlova, Siwei Zhang, Ari Sudwarts, Hanwen Zhang, Stanislau Smirnou, Seul Kee Byeon, Christina Thapa, Xiaotong Sun, Kimberley Stephenson, Xiaojie Zhao, Brendan Jamison, Moorthi Ponnusamy, Xin He, Julie A Schneider, Akhilesh Pandey, David A Bennett, Zhiping P Pang, Alan R Sanders, Hugo J Bellen, Gopal Thinakaran, Jubao Duan

Faculty, Staff and Students Publications

Despite genome-wide association studies (GWAS) of late-onset Alzheimer’s disease (LOAD) having identified many genetic risk loci1–3, the underlying disease mechanisms remain largely unclear. Determining causal disease variants and their LOAD-relevant cellular phenotypes has been a challenge. Here, using our approach for identifying functional GWAS risk variants showing allele-specific open chromatin, we systematically identified putative causal LOAD-risk variants in human induced pluripotent stem (iPS)-cell-derived neurons, astrocytes and microglia, and linked a PICALM LOAD-risk allele to a microglial-specific role of PICALM in lipid droplet (LD) accumulation. Allele-specific open-chromatin mapping revealed functional risk variants for 26 LOAD-risk loci, mostly …

Author Correction: Clonal Dynamics And Somatic Evolution Of Haematopoiesis In Mouse, Chiraag D Kapadia, Nicholas Williams, Kevin J Dawson, Caroline Watson, Matthew J Yousefzadeh, Duy Le, Kudzai Nyamondo, Sreeya Kodavali, Alex Cagan, Sarah Waldvogel, Xiaoyan Zhang, Josephine De La Fuente, Daniel Leongamornlert, Emily Mitchell, Marcus A Florez, Krzysztof Sosnowski, Rogelio Aguilar, Alejandra Martell, Anna Guzman, David Harrison, Laura J Niedernhofer, Katherine Y King, Peter J Campbell, Jamie Blundell, Margaret A Goodell, Jyoti Nangalia

Faculty, Staff and Students Publications

No abstract provided.

Repeated Withdrawal Of A Glpr Agonist Induces Hyperleptinemia And Deteriorates Metabolic Health In Obese Aging Um-Het3 Mice, Nisi Jiang, Jiyuan Yin, Noah Lawrence, Jieyi Meng, Laurence T Maeyens, Ziying Xu, Xin Li, Mbolle Ekane, Ariana Chaudhary, Pengju Cao, Guannan Li, Carolina Solis-Herrera, Yi Zhu, Shangang Zhao

Children’s Nutrition Research Center Staff Publications

GLP-1-based therapy is highly effective in combating aging-associated metabolic diseases. However, the metabolic effects of frequent withdrawal from this therapy in aged, obese mice have not been previously studied. In this study, aged obese UM-HET3 mice were assigned to three groups: Group 1 received no liraglutide treatment (Lira OFF); Group 2 underwent 3 cycles of treatment followed by withdrawal (Lira ON/OFF); and Group 3 remained on continuous treatment (Lira ON). As expected, mice in Group 3 showed reduced body weight and food intake, along with improved metabolic health. In contrast, mice in Group 2 developed hyperleptinemia and visceral fat expansion, …