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Cv: Marne Bailey (Biology), Marne Bailey

Biology Department Faculty Curricula Vitae

No abstract provided.

Scalable Biosynthesis And Recovery Of Poly-3-Hydroxybutyrate Produced From Cotton-Derived Glucose By Cupriavidus Necator, Ashley M. Clark, Lucia E. Gargano, Gabriella M. Fioravanti, Hannah M. Schapiro, Ron G. Kander

School of Design and Engineering Papers

To combat the growing issue of petroleum plastic waste, alternative bio-based polymers are being developed. Many of these biopolymers are made from bio-derived materials, or are biodegradable, but the most promising polymers fall in both categories. Polyhydroxyalkanoates (PHAs) are one such class of polymers, and poly-3-hydroxybutyrate (P3HB), the most popular PHA, has shown great potential. This study utilized two types of cotton-derived glucose, alongside commercial glucose, as a feedstock for the biosynthesis of P3HB by Cupriavidus necator (also known as Ralstonia eutropha). The fermentation took place in a 2-L bioreactor, showing potential for scale-up. A single-solvent extraction method was …

Evaluation Of Anti-Bacterial Efficacy Of Ginger, Resin Gum, And Nigella Sativa Irrigants Against Enterococcus Faecalis: An In Vitro Study, Iman El Ghazzawy, Leen Imad Hasbini, Reem Chamseddine, Wael Betbout, Roula Abiad

International Arab Journal of Dentistry

Objectives: To evaluate the antibacterial efficacy of Ginger, Resin Gum, and Nigella Sativa, against Enterococcus Faecalis.

Methods: Thirty-eight extracted single-rooted premolars were inoculated with E.faecalis, except the negative control, and incubated for 4 weeks. After instrumentation samples were divided into 4 groups (n=7) according to final irrigation: NaOCl+EDTA (Group A), Nigella sativa (B), Resin Gum (C), Ginger (D), plus 2 control groups (n=5): Saline (E), and Saline without bacterial inoculation (F). Cultures were collected at baseline and after irrigation.

Results: One-way ANOVA showed that in groups A-D a statistically significant reduction of bacterial load was observed at …

An Examination Of The Experiences Of An African American Male Diver On A Power Four Swim Team: An Elite Interview, Steven N. Waller Ph.D., Tiffany M. Quash Ph.D.

International Journal of Aquatic Research and Education

Despite the incremental increase in the number of Black people who are learning to swim, the number of Black divers has not kept pace. In the NCAA Database, swimmers and divers were not segmented; thus, they all appear in the category of “swimming” by race and sex. When viewing the 2024 Division I NCAA Demographics Database, 89 (.02%) of 4307 student-athletes participating in swimming were Black women. For men, the data is equally dismal, revealing that 81 (.03%) of 2,608 student-athletes who were identified as swimmers were Black. The purpose of this research note is to examine the developmental experiences …

Molecular Determinants Of Neoadjuvant Chemotherapy Resistance In Breast Cancer: An Analysis Of Gene Expression And Tumor Microenvironment, Hedda Michelle Guevara-Nieto, Carlos A. Orozco-Castaño, Rafael Parra-Medina, Jenny Nathaly Poveda-Garavito, Jone Garai, Jovanny Zabaleta, Liliana López-Kleine, Alba Lucia Combita

School of Graduate Studies Faculty Publications

Neoadjuvant chemotherapy (NAC) is a critical component of breast cancer treatment, but the molecular mechanisms underlying resistance remain poorly understood. This study aimed to identify transcriptomic changes associated with NAC resistance across four breast cancer subtypes: Luminal A, Luminal B/HER2-positive, Luminal B/HER2-negative, and Triple-Negative Breast Cancer (TNBC). RNA-seq analysis was performed on paired pre- and post-NAC breast cancer samples from 32 nonresponders. Differentially expressed genes (DEGs) were identified, and functional enrichment analyses were conducted. Protein-protein interaction (PPI) networks were constructed to identify hub genes. Tumor microenvironment (TME) infiltration was estimated using deconvolution algorithms. The results revealed distinct gene expression profiles …

Yx0798 Is A Highly Potent, Selective, And Orally Effective Cdk9 Inhibitor For Treating Aggressive Lymphoma, Vivian Jiang, Yu Xue, Hong Kim, Qingsong Cai, Tianci Zhang, Lei Nie, Joseph Mcintosh, Yang Liu, Haiying Chen, Jia Zhou, Michael Wang

Faculty, Staff and Student Publications

Nongenetic transcription evolution has been increasingly explored and recognized to drive tumor cell progression and therapeutic resistance. As the regulation hub of transcription machinery, cyclin-dependent kinase 9 (CDK9) is the gatekeeper of RNA polymerase II transcription, and CDK9 dysfunction results in transcriptomic reprogramming and tumor cell progression. We recently reported that the heat shock protein 90 (HSP90)-MYC-CDK9 network drives therapeutic resistance in mantle cell lymphoma (MCL) through transcriptomic reprogramming. We also showed that targeting CDK9 by AZD4573 and enitociclib is a safe and effective treatment in preclinical Mantle Cell Lymphoma (MCL) models, supporting CDK9 as a valid therapeutic target for …

Landscape And Clinicopathologic Features Of Ras Pathway Mutations In Chronic Myelomonocytic Leukemia, Guillermo Montalban-Bravo, Sanam Loghavi, Ziyi Li, Kelly Chien, Rashmi Kanagal-Shamanna, Alex Bataller, Anuya Natu, Mark Gurney, Alexandre Bazinet, Danielle Hammond, Koji Sasaki, Gautam Borthakur, Mahesh Swaminathan, Courtney Dinardo, Tapan Kadia, Farhad Ravandi, Naval Daver, Nicholas Short, Naveen Pemmaraju, Ghayas Issa, Terra L Lasho, Christy M Finke, Aref Al-Kali, Clifford Csizmar, Hassan Alkhateeb, Naseema Gangat, Abhishek A Mangaonkar, Carlos Bueso-Ramos, Ayalew Tefferi, Hagop Kantarjian, Guillermo Garcia-Manero, Mrinal M Patnaik

Faculty, Staff and Student Publications

RAS pathway (RASp) mutations induce proliferative features, and promote transformation in chronic myelomonocytic leukemia (CMML). However, the unique clonal landscape and hierarchy of distinct RASp mutations remain unexplored. To characterize the landscape, architecture, and implications of unique RASp mutations in CMML, we evaluated a cohort of 814 patients with CMML. We identified 461 RASp mutations among 342 patients (42%). N/KRAS and CBL mutations were the most common, frequently involved the P-loop or RING domains, respectively, and frequently appeared as dominant events (63% and 65%, respectively). BRAF, NF1, and PTPN11 mutations spanned throughout the gene structure, and frequently appeared as subclonal …

Optimizing Genetic Ancestry Adjustment In Dna Methylation Studies: A Comparative Analysis Of Approaches, Kira D Höffler, Seyma Katrinli, Matthew W Halvorsen, Anne-Kristin Stavrum, Kevin S O'Connell, Alexey Shadrin, Srdjan Djurovic, Ole A Andreassen, James J Crowley, Jan Haavik, Kristen Hagen, Gerd Kvale, Kerry Ressler, Bjarne Hansen, Jair C Soares, Gabriel R Fries, Alicia K Smith, Stéphanie Le Hellard

Faculty, Staff and Student Publications

Background: Genetic ancestry is an important factor to account for in DNA methylation studies because genetic variation influences DNA methylation patterns. One approach uses principal components (PCs) calculated from CpG sites that overlap with common SNPs to adjust for ancestry when genotyping data is not available. However, this method does not remove technical and biological variations, such as sex and age, prior to calculating the PCs. The first PC is therefore often associated with factors other than ancestry.

Methods: We developed and adapted the adapted EpiAnceR+ approach, which includes (1) residualizing the CpG data overlapping with common SNPs for control …

Quantifying Interest In And Sentiment Of Online Media About Greenhouse Gas Emissions From Cattle Production In The United States, Michael L. Smith, Jinho Jung, Nicole Olynk Widmar, Danielle J. Ufer, Maria Berikou, Jayson Lusk

Department of Agricultural Economics Faculty Publications

The public is paying increased attention to the environmental impacts associated with cattle production systems in the US. Thus, cattle producers are increasingly exploring ways to communicate their efforts to reduce those environmental and climate impacts. This study uses online and social media data from 2018 to 2022 to examine public interest in and sentiment about beef and dairy cattle production when discussed within the context of greenhouse gas (GHG) emissions. Variation in mentions and net sentiment over the reporting period is quantified and analyzed. Over the period of data collection, which was interrupted by the COVID-19 pandemic, we find …

Needs Analysis Of Interactive Learning Media For Teachingheat Transfer In Physics: Students’ And Teachers’Perspectives, Rizki Eka Shintya, Ika Mustika Sari, Ida Kaniawati

Jurnal Pendidikan Sains

Heat transfer material in physics is known to be abstract. This study specifically analyzes the conceptual difficulties, and visualization needs specific to this material, which is different from the analysis of physics needs in general. This analysis does not only look for the need for traditional media but explicitly looks for the need for interactive media (simulation, animation, virtual laboratory). Therefore, this study aims to identify the need for interactive learning media in physics education, specifically in the teaching of heat transfer, from the perspective of students and teachers in West Java, Indonesia. Using a quantitative descriptive survey, data were …

Efficacy Of Teaching At The Right Level Approach Combined With The Problem-Based Learning Model On Science Learning Outcomes At Middle School, Heri Syahputra Azhar Panjaitan, Ryan Dwi Puspita

Jurnal Pendidikan Sains

This research seeks to evaluate the efficacy of the Teaching at the Right Level (TaRL) strategy in conjunction with the Problem-Based Learning (PBL) model on the scientific learning outcomes of eighth-grade students at middle school Islam Terpadu Khairul Imam. This research addresses the inadequate scientific problem-solving abilities and science learning outcomes of Indonesian students, necessitating a more interactive and individualized instructional technique. The methodology used is a quasi-experimental design with a nonequivalent control group. The sample included two purposively chosen eighth-grade classes: one experimental class (n=25) underwent the TaRL–PBL intervention, whereas the control class (n=25) simply used the lecture approach. …

Synergistic Effects Of Orifice Geometry And Inclination Angle On The Damping Performance Of Tuned Liquid Column Vibration Absorbers, Mohamed M. Abou Elenin, Younes K. Younes, Mohamed F. Younes

Mansoura Engineering Journal

This study experimentally investigates the dynamic damping performance of passive tuned liquid column vibration absorbers (TLCVAs), focusing on the influence of vertical column inclination angle and orifice disc configuration. Free vibration tests were conducted on a primary system equipped with a TLCVA using a custom-designed test rig. The experimental framework systematically varied inclination angles from to and tested both single-hole and multi-perforated orifice discs, each designed with an equivalent total flow area. A MATLAB-based signal processing framework was employed to analyze time-domain responses, and the logarithmic decrement method was applied to determine the damping ratio of the primary system. The …

Tableau Part Ii - October 2025, Rubab Shahzad

Day Family Research Lab Workshop Series

Part Two of Introduction to Tableau. Learn to make cool visualizations using Tableau. A hands-on opportunity where we will go over calculated fields, hierarchies, unions, dashboards, and stories.

Prior experience with Tableau is recommended

Climate Change Projections Through Optimized Machine Learning And Deep Learning Models: A Comprehensive Analysis, Hala H. Youssef, Salma S. Mohammed, Hanan M. Amer, Abeer T. Khalil

Mansoura Engineering Journal

One major worldwide issue that has far-reaching effects on environmental stability and the avoidance of natural disasters is climate change. Developing efficient mitigating strategies depends on precise climate change forecasts. To predict important climate change indicators, including temperature fluctuations, greenhouse gas (CO2, N2O, CH4, and SF6) emissions, population dynamics, sea level changes, Arctic Sea ice extent, and Antarctica mass, this study evaluated the predictive capabilities of several Machine Learning (ML) and Deep Learning (DL) techniques. The set of machine learning algorithms includes Multiple Linear Regression (MLR), K-Nearest Neighbors (KNN), Support Vector Machines (SVMs), Artificial Neural Networks (ANN), Random Forest (RF), …

Flawed Analysis Invalidates Claim Of A Strong Yellowstone Trophic Cascade After Wolf Reintroduction: A Comment On Ripple Et Al. (2025), Dan R. Macnulty, David Cooper, Michael Procko, T.J. Clark-Wolf

Aspen Bibliography

Ripple et al. (2025) recently argued that large carnivore recovery in Yellowstone National Park triggered one of the world’s strongest trophic cascades, citing a ∼1500 % increase in willow crown volume derived from plant height data. In this comment, we show that their conclusion is invalid due to fundamental methodological flaws. These include use of a tautological volume model, violations of key modeling assumptions, comparisons across unmatched plots, and the misapplication of equilibrium-based metrics in a non-equilibrium system. Additionally, Ripple et al. rely on selectively framed photographic evidence and omit critical drivers such as human hunting in their causal attribution. …

Organism-Specific Sequence Motifs Link Ribosomal Rnas To Brain Disorders, Isidore Rigoutsos, Stepan Nersisyan, Eric Londin, Iliza Nazeraj, Bonnie Dong, Anastasios Vourekas, Phillipe Loher

Computational Medicine Center Faculty Papers

We report that in humans, mice, fruit flies, and worms, the ribosomal RNAs and the transcribed spacers of 45S are densely packed with organism-specific sequence motifs that are primarily shared with nervous system genes. The human ribosomal RNAs and 45S spacers contain 1,723 such motifs. Specific combinations of these motifs are predominantly found in 3,430 human nervous system genes, of which 1,046 are genes associated with brain disorders, including autism spectrum disorder and schizophrenia. The sequences of the 1,723 motifs and their locations in the introns and exons of nervous system genes are unique to primates. Experimental evidence indicates that …

10.13.2025 Ored Connect, Liz Williamson

ORED Newsletter

• ORED Small Grants Program RFP
• Mississippi Impact Grants RFP
• Contest to Promote Lab Practices
• Field Fest
• AAAS Membership for Faculty, Staff, and Students 

Understanding The Nutrition Ecology And Related Distal And Proximal Research Gaps Impacting School-Aged Children's And Adolescents' Functioning-A Report From The "Biomarkers Of Nutrition For Development: Knowledge Indicating Dietary Sufficiency (Bond-Kids)" Project Working Group 2., Maureen M Black, Meg M Bruening, Amy Carroll-Scott, Jayna M Dave, Kristie L Ebi, Lora L Iannotti, Susan L Johnson, Lorrene D Ritchie, Elizabeth Y Jimenez, Alison L Steiber, Daniel J Raiten

Children’s Nutrition Research Center Staff Publications

Nutrition is critical to the health, development, and well-being of children and adolescents, operating through nutrients and the social and physical influences of dietary behaviors. Child and adolescent growth and development depend on complex biological systems interacting with the nutrition ecology. In this review, we focus on bidirectional interactions with the multilevel nutrition ecology, including distal systems (climate, geopolitical, and food systems) and proximal systems (community food options; health, social, and food services; and school policies and programs), all mediated by the family. Thus, the impact of nutrition on children's and adolescents' functional outcomes is dependent on understanding the multilevel …

Characterization Of Suspicious Prostate Lesions At Multiparametric Mri With Dynamic 68 Ga-Gozetotide Pet/Ct, Daniel Parrott, Qing Yuan, Daniella Pinho, Yin Xi, Daniel N Costa, Alberto Diaz De Leon, Marianna Dakanali, Xiankai Sun, Orhan K Oz, Spencer Bowen, Neil M Rofsky, Dana Mathews, Ivan Pedrosa

Faculty, Staff and Student Publications

Background: Prostate cancer (PCa) will affect approximately 12% of US men in their lifetime and remains the 2nd most common cause of cancer-specific death. However, there is a broad spectrum of severity of PCa; some require aggressive treatment and others can "watch-and-wait". Distinction of clinically significant prostate cancer (csPCa) from indolent PCA with current imaging methods remains challenging.

Objective: This study aims to evaluate dynamic prostate specific membrane antigen (PSMA) positron emission tomography (PET/CT) in the characterization of suspicious prostate lesions identified on multiparametric MRI (mpMRI).

Methods: Prospective study of biopsy-naïve patients with at least one Prostate Imaging and Reporting …

Inhibition Of Osteosarcoma Lung Metastases By Β-Glucan And Cd40 Agonist Is Mediated By Activation Of Macrophages And Nk Cells, Pradeep Shrestha, Rejeena Shrestha, Eugenie S Kleinerman

Faculty, Staff and Student Publications

Background: Osteosarcoma (OS) lung metastases remain a significant therapeutic challenge. Innate immune activation is a promising therapeutic approach. Innate immune agonists can modulate the tumor immune microenvironment and improve therapeutic response.

Methods: Using an experimental syngeneic OS lung metastasis BALB/c mouse model with K7M3-luc OS cells, we evaluated the antitumor effects of yeast-derived particulate β-glucan in prevention and therapeutic settings. We then assessed whether the CD40 agonist (CD40a) in combination with β-glucan increased therapeutic response in two different immune-competent mouse models of OS lung tumor burden.

Results: In the pretreatment settings, mice treated with β-glucan prior to OS cell infusion …

Managing Chickens From Chicks To Peak Egg Production, Joseph Okoh, Essence Perry

All Current Publications

Chickens were first domesticated for cultural purposes, but selective breeding has focused on egg production. Choosing the right breeds and good management practices are essential for farmers to maximize egg yield, quality, and safety. This fact sheet covers poultry history, top egg-laying breeds, egg anatomy, nutrition, and practical tips to help farmers improve productivity and run successful egg production ventures.

A Farmer's Guide To Egg Quality, Safety, And Flock Health, Joseph Okoh, Essence Perry

All Current Publications

Eggs are a valuable source of nutrition and income for many backyard and smallholder farmers. To ensure a steady supply of high-quality eggs, it's essential to understand the key factors that influence hens’ health and productivity. From proper nutrition to effective lighting and disease prevention, each decision you make affects your flock’s performance. This guide offers practical advice to help you raise resilient, high-laying hens and build a successful small-scale egg production system, no matter your level of experience.

Decoding Genetic And Network Signatures Of Susceptibility To Orthodontic Root Resorption: Toward Predictive And Personalized Orthodontics, Casey Morishige, Morgan Mecham, Gabriel Eisenhuth, Shilpa Bhandi, Frank Licari, Shankargouda Patil

Annual Research Symposium

No abstract provided.

Genetic Engineering Of Esophageal Organoids: Crispr-Based Knock-In For Cell Lineage Tracing, Kyung-Pil Ko, Jae-Il Park

Faculty, Staff and Student Publications

Esophageal organoids serve as powerful systems to study epithelial lineage hierarchies and cancer biology. Gene manipulation in these organoids has traditionally involved overexpression or knockout strategies. However, CRISPR-/Cas9-based knock-in (KI) approaches now enable precise cell lineage tracing and live imaging. Here, we describe protocols to generate fluorescent KI organoids from murine esophageal epithelium by tagging Krt13 (BFP) and Sox2 (mNeon). These dual-reporter organoids allow direct monitoring of growth dynamics and differentiation trajectories. We outline CRISPR/Cas9 design, donor construction using homology-independent approaches (CRISPaint), delivery into organoid cells, enrichment and single-clone isolation, and validation by fluorescence. For organoids, homology-directed repair (HDR) can …

Re-Survey Of Blastocystis Infection In Free-Living Birds From Urban Xinxiang City, Xuehan Liu, Yingying Cao, Di An, Chengshui Liao, Ruibiao Wang, Bo Wen, Chunling Zhu, Huarun Sun, Longfei Zhang, Baoliang Qin, Yanhui Wang, Jianhe Hu, Yueyu Bai, Ke Ding, Lei Wang

The Thai Journal of Veterinary Medicine

Blastocystis is the most ubiquitous intestinal protozoan parasite found in humans and animals worldwide. Commonly, ST7 and ST6 are the major Blastocystis subtypes reported in birds, and their frequencies fluctuate greatly with various factors. However, little literature is available on the prevalence and subtype characteristics of this parasite in free-living wild birds in the same city. For this purpose, a total of 114 fresh fecal specimens were collected from wild free-living birds in urban districts of Xinxiang city and tested for Blastocystis using PCR of the barcoding region of the small subunit ribosomal RNA (SSU rRNA) gene. The positive isolates …

Evaluation Of Different Design Standards For The Design Of Axial Loaded Concrete Filled Steel Tube Columns Under Fire, Ebtsam Youssef Ibrahim Abd El Ghaffar, Nabil Said Mahmoud, Fikry A. Salem, Mohammed. M. Ghannam

Mansoura Engineering Journal

This paper compares various codes and standards for the behavior of “Concrete-Filled Steel Tubes” (CFST) columns under fire and axial load. The codes evaluated include European standards (EC4.2 and EC3.2), the American standard (AISC 360), and the Australian standard (AS/NZS 2327). The fire resistance of Concrete-Filled Steel Tubular (CFST) and steel hollow (SH) columns was assessed using a computer program developed with Visual Studio .NET. The program's results were compared with previous experimental data to evaluate the accuracy of various codes and standards in predicting the behavior of these columns under fire conditions. This study highlights the importance of selecting …

Primary Hyperaldosteronism, Joanna Lam

The Kabod

This paper will give an overview of primary hyperaldosteronism, which is a condition characterized by the excess production of aldosterone from the adrenal glands. Since its discovery in 1954 by James Conn, primary hyperaldosteronism has been discovered to have a variety of causes, with the more common ones being either benign tumors or inherited disorders such as congenital adrenal hyperplasia. Affected patients display conditions such as hypertension or hypokalemia, which may lead to symptoms including headaches, blurred vision, or dizziness. This paper will cover the anatomy of the adrenal glands, along with the normal physiology and synthesis of aldosterone. Aldosterone’s …

Crayfishes Of Kansas: List Of Taxa, Synonyms, And References, Mark E. Eberle

Sternberg Museum of Natural History Faculty Publications

There are 14 species of crayfishes (Decapoda: Cambaridae) reported from Kansas, although there are questions about the systematics of some taxa. These species are listed by their current names and the synonyms under which they have been reported since 1885, along with their conservation status. Published references that include each species in Kansas are also noted. In addition, information about species with type localities in Kansas and unresolved taxonomic issues are summarized. The list of species has been updated in 2025 to include two species introduced to Kansas and other new information.

Draft Genome Sequences Of Burkholderia And Paraburkholderia Strains Isolated From Panicum Virgatum Soil And Roots At The Lux Arbor Reserve In Michigan, Usa, H. Kehlet-Delgado, R. H. Petipas, A. A. Antoch, Jeffrey S. Norman, X. Li, R. A. White Iii, S. E. Evans, L. K. Tiemann, M. L. Friesen

Biology Faculty Works

We present draft genomes of two Paraburkholderia strains and two Burkholderia strains. Three strains were isolated from surrounding soils and one from roots of switchgrass (Panicum virgatum) in Michigan, USA.

Targeting The Bcl2 Family: Advances And Challenges In Bh3 Mimetic-Based Therapies, Nabanita Mukherjee, James Sheetz, Yiqun Shellman

Student Papers, Posters & Projects

The BCL2 family of proteins plays a pivotal role in regulating apoptosis and cellular homeostasis, making them critical therapeutic targets in cancer and other diseases characterized by pathological cell survival. BH3 mimetics, small molecules that selectively inhibit anti-apoptotic BCL2 family members, have achieved significant clinical success, particularly in hematologic malignancies. However, several challenges remain, including resistance mechanisms, toxicity (such as MCL1 inhibitor-associated cardiotoxicity), and the intricate balance between apoptotic and non-apoptotic functions. This review provides a comprehensive overview of BCL2 family biology, the development and clinical application and outcomes of BH3 mimetics, and the emerging resistance mechanism known as double-bolt …