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Articles 7561 - 7590 of 256734
Full-Text Articles in Entire DC Network
Investigating Prognostic Features In High-Grade Serous Ovarian Cancer Through Gene Regulatory Network Inference With Single-Cell Transcriptomic Profiles, Toshiyuki Itai, Yulin Dai, Wendao Liu, Dung-Fang Lee, Zhongming Zhao
Investigating Prognostic Features In High-Grade Serous Ovarian Cancer Through Gene Regulatory Network Inference With Single-Cell Transcriptomic Profiles, Toshiyuki Itai, Yulin Dai, Wendao Liu, Dung-Fang Lee, Zhongming Zhao
Faculty, Staff and Student Publications
This study aimed to identify prognostic features in high-grade serous ovarian cancer (HGSOC) through the application of gene regulatory network (GRN) inference with single-cell RNA-sequencing (scRNA-seq) profiles. To achieve this goal, we developed a workflow comprising scRNA-seq analysis, metacell construction, GRN inference, and a binary classification task for prognosis prediction. We curated 118,173 cells from HGSOC patients in three conditions (Before-chemotherapy, After-chemotherapy, and control samples) from previous studies, and then constructed 1,211 metacells. GRN inference analysis revealed 312 regulons, each consisting of one transcription factor and its targeted features. For prognosis evaluation, we used bulk RNA-seq data covering 342 HGSOC …
Development Of A Targeted Bioprotac Degrader Selective For Misfolded Sod1, Christen G Chisholm, Rachael Bartlett, Mikayla L Brown, Emma-Jayne Proctor, Natalie E Farrawell, Jody Gorman, Fabien Delerue, Lars M Ittner, Kara L Vine-Perrow, Heath Ecroyd, Neil R Cashman, Darren N Saunders, Luke Mcalary, Jeremy S Lum, Justin J Yerbury
Development Of A Targeted Bioprotac Degrader Selective For Misfolded Sod1, Christen G Chisholm, Rachael Bartlett, Mikayla L Brown, Emma-Jayne Proctor, Natalie E Farrawell, Jody Gorman, Fabien Delerue, Lars M Ittner, Kara L Vine-Perrow, Heath Ecroyd, Neil R Cashman, Darren N Saunders, Luke Mcalary, Jeremy S Lum, Justin J Yerbury
Faculty, Staff and Student Publications
The accumulation of misfolded proteins underlies a broad range of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Due to their dynamic nature, these misfolded proteins have proven challenging to target therapeutically. Here, we specifically target misfolded disease variants of the ALS-associated protein superoxide dismutase 1 (SOD1), using a biological proteolysis targeting chimera (BioPROTAC) composed of a SOD1-specific intrabody and an E3 ubiquitin ligase. Screening of intrabodies and E3 ligases for optimal BioPROTAC construction reveals a candidate capable of degrading multiple disease variants of SOD1, preventing their aggregation in cells. Using CRISPR/Cas9 technology to develop a BioPROTAC transgenic mouse line, we …
Tackling The Burden Of Envenomation In Africa: Advances, Challenges, And Strategic Priorities For Enhanced Diagnosis And Treatment, Khawla Ammouch, Nihal Mesmoudi, Noureddine Hammani, Jacob Galan, Abdellah Moustaghfir, Reto Stöcklin, Naoual Oukkache
Tackling The Burden Of Envenomation In Africa: Advances, Challenges, And Strategic Priorities For Enhanced Diagnosis And Treatment, Khawla Ammouch, Nihal Mesmoudi, Noureddine Hammani, Jacob Galan, Abdellah Moustaghfir, Reto Stöcklin, Naoual Oukkache
Human Genetics Publications
Venomous animal envenomation remains a significant but neglected public health problem worldwide, with an estimated 5.4 million cases and up to 138,000 deaths annually. The burden is particularly acute in tropical and subtropical regions, especially sub-Saharan Africa, where rural and vulnerable populations face limited access to effective antivenoms and healthcare. Despite this, comprehensive data on envenomation incidence, clinical management, and outcomes remain scarce, hampering efforts to develop effective prevention and treatment strategies. This review synthesizes current knowledge on venomous animal diversity, epidemiology, and clinical manifestations globally, with a focus on Africa’s unique challenges. We examine critical gaps in antivenom production, …
Data-Driven Modeling Of Dynamics And Adaptation In Mapk Pathway, Elisha Erzoah, Maria Emelianenko, Mariaelena Pierobon
Data-Driven Modeling Of Dynamics And Adaptation In Mapk Pathway, Elisha Erzoah, Maria Emelianenko, Mariaelena Pierobon
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
[Kyda] The Role Of Human Movement On The Spread Of Mosquito-Borne Diseases, Omar Saucedo
[Kyda] The Role Of Human Movement On The Spread Of Mosquito-Borne Diseases, Omar Saucedo
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Exploring The Role Of Environmental Heterogeneity And Transmission In Mutualist Coexistence, Alexandra Campbell, Tom E.X. Miller
Exploring The Role Of Environmental Heterogeneity And Transmission In Mutualist Coexistence, Alexandra Campbell, Tom E.X. Miller
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
[Kyda] Biologically Grounded Surrogate-Driven Parameter Inference For Sparsely Observed Dynamical Systems, Joshua C. Macdonald
[Kyda] Biologically Grounded Surrogate-Driven Parameter Inference For Sparsely Observed Dynamical Systems, Joshua C. Macdonald
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
[Kyda] The Behavioral Spillover Effect: Modeling Behavioral Interdependencies In Multi-Pathogen Dynamics, Leah Lejeune, Omar Saucedo, Lauren M. Childs, Navid Ghaffarzadegan
[Kyda] The Behavioral Spillover Effect: Modeling Behavioral Interdependencies In Multi-Pathogen Dynamics, Leah Lejeune, Omar Saucedo, Lauren M. Childs, Navid Ghaffarzadegan
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Modeling Synaptic Dysfunction As Neural Contagion: A Graph-Based Sedr Framework For Simulating Signal Spread, Michelle Marfo, Dr. Padmanabhan Seshaiyer, Alonso Ogueda-Oliva
Modeling Synaptic Dysfunction As Neural Contagion: A Graph-Based Sedr Framework For Simulating Signal Spread, Michelle Marfo, Dr. Padmanabhan Seshaiyer, Alonso Ogueda-Oliva
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Following Carbon: Pathway And Flux Representations Of Ecosystems, Caner Kazanci
Following Carbon: Pathway And Flux Representations Of Ecosystems, Caner Kazanci
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Immune Dysregulation In Covid-19: Mathematical Modeling Of The Within-Host Dynamics, Pagnapech Ngoun, Nicolas Alvarez, Ayesh Awad, Hwayeon Ryu
Immune Dysregulation In Covid-19: Mathematical Modeling Of The Within-Host Dynamics, Pagnapech Ngoun, Nicolas Alvarez, Ayesh Awad, Hwayeon Ryu
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
[Reev] Developing A Stage-Structure Stoichiometric Aquatic Tri-Trophic Food Chain Model, Ghislaine Niyodusenga, Cecilia Norris, Caroline Orza, Jing Li, Angela Peace, Greg Mayer, Rebecca A. Everett
[Reev] Developing A Stage-Structure Stoichiometric Aquatic Tri-Trophic Food Chain Model, Ghislaine Niyodusenga, Cecilia Norris, Caroline Orza, Jing Li, Angela Peace, Greg Mayer, Rebecca A. Everett
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Mathematical Model Of Ovarian Cancer Tumor Growth In Mice, Jessica A. Hoffman
Mathematical Model Of Ovarian Cancer Tumor Growth In Mice, Jessica A. Hoffman
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Analyzing The Effect Of A Holling Type Iii Functional Response On Predator-Prey Dynamics, Lawrence G. Seminario-Romero, Richard Rebarber, Brigitte Tenhumberg
Analyzing The Effect Of A Holling Type Iii Functional Response On Predator-Prey Dynamics, Lawrence G. Seminario-Romero, Richard Rebarber, Brigitte Tenhumberg
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Reconstructing Gene Regulatory Networks From Time-Series Data In Knime, Raina Robeva
Reconstructing Gene Regulatory Networks From Time-Series Data In Knime, Raina Robeva
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Model-Free Identification Of Relevant Variables And Modules From Response Data, Alan Veliz-Cuba, David Murrugarra
Model-Free Identification Of Relevant Variables And Modules From Response Data, Alan Veliz-Cuba, David Murrugarra
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Self-Assembly And Self-Folding Models Of Viral Capsids, John R Jungck
Self-Assembly And Self-Folding Models Of Viral Capsids, John R Jungck
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
The Effect Of High-Intensity Interval Training On Visceral Adipose Tissue In Type 2 Diabetes: A Systematic Review, Ivan D. Delgado, Julio C. Delgado, Ryan D. Burns
The Effect Of High-Intensity Interval Training On Visceral Adipose Tissue In Type 2 Diabetes: A Systematic Review, Ivan D. Delgado, Julio C. Delgado, Ryan D. Burns
International Journal of Exercise Science
International Journal of Exercise Science 18(5): 1321-1333, 2025. https://doi.org/10.70252/YEUF2363 Visceral adipose tissue (VAT) is a significant contributor to insulin resistance in type 2 diabetes (T2D). The effectiveness of time-efficient high-intensity interval training (HIIT) in reducing VAT has not been reviewed. A systematic search conducted on PubMed, Embase, and SPORTDiscus up to April 2025 for randomized controlled trials that compared HIIT with non-exercise control and quantified VAT using imaging identified five trials (n = 138) that met inclusion criteria. Risk of bias was assessed using a nine-item modified PEDro scale. Four trials reported significant reductions in VAT after 8-12 weeks of …
Effects Of A Personalized Fitness Program Provided By Undergraduate Exercise Science Students On Attitudes Toward Exercise, Mental Health, And Quality Of Life, Kris M. Cleveland, Jacob Fike, Scott Peterson
Effects Of A Personalized Fitness Program Provided By Undergraduate Exercise Science Students On Attitudes Toward Exercise, Mental Health, And Quality Of Life, Kris M. Cleveland, Jacob Fike, Scott Peterson
International Journal of Exercise Science
International Journal of Exercise Science 18(4): 1334-1343, 2025. https://doi.org/10.70252/IYNS6043 Personalized fitness training is designed to improve physical health and fitness, but may also promote mental health and well-being. The purpose of this study was to determine whether there are positive psychological outcomes for clients participating in a community-based personalized fitness program led by undergraduate Exercise Science students. A total of 44 participants completed a battery of psychological scales both before and after participation in a 12-week university-sponsored personalized fitness training program. Psychological measures included the Exercise Attitudes Scale, Self-Efficacy Scale for Exercise, Short Warwick-Edinburgh Mental Well-Being Scale, Health Status Questionnaire, …
[Kadel] Robust Basins, Fragile Attractors: A New View On Boolean Network Dynamics, Claus Kadelka
[Kadel] Robust Basins, Fragile Attractors: A New View On Boolean Network Dynamics, Claus Kadelka
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Probabilistic Modeling Of Antibody Kinetics Post Infection And Vaccination, Rayanne Luke, Prajakta Bedekar, Anthony J. Kearsley
Probabilistic Modeling Of Antibody Kinetics Post Infection And Vaccination, Rayanne Luke, Prajakta Bedekar, Anthony J. Kearsley
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
[Kadel] Modular Control Of Boolean Network Models, Elena Dimitrova, David Murrugarra
[Kadel] Modular Control Of Boolean Network Models, Elena Dimitrova, David Murrugarra
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Mentoring First-Year Stem Students Through Collaborative Research In The Haynes Scholars Program, Alex Capaldi, Laura Tipton
Mentoring First-Year Stem Students Through Collaborative Research In The Haynes Scholars Program, Alex Capaldi, Laura Tipton
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
[Kadel] Understanding Aging In Worms Using Boolean Modeling, Brandilyn Stigler
[Kadel] Understanding Aging In Worms Using Boolean Modeling, Brandilyn Stigler
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Machine Learning–Based Prediction Of Bleeding Risk In Factor Xi Deficiency, Tracey G. Oellerich, Stephanie Reitsma, Alisa Wolberg, Karin Leiderman, Suzanne Sindi
Machine Learning–Based Prediction Of Bleeding Risk In Factor Xi Deficiency, Tracey G. Oellerich, Stephanie Reitsma, Alisa Wolberg, Karin Leiderman, Suzanne Sindi
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Histamine And Serotonin Impact Anopheles Stephensi Population Dynamics And Malaria Transmission: Perspectives From Mathematical Modeling, Michael Robert
Histamine And Serotonin Impact Anopheles Stephensi Population Dynamics And Malaria Transmission: Perspectives From Mathematical Modeling, Michael Robert
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
[Lele] Early Careers In Mathematical Biology "Mathematical Analysis Of Exposure-Dependent Transmission With Environmental Reservoirs", Mohammad Mihrab Uddin Chowdhury, Angela Peace, Matthew J. Gray
[Lele] Early Careers In Mathematical Biology "Mathematical Analysis Of Exposure-Dependent Transmission With Environmental Reservoirs", Mohammad Mihrab Uddin Chowdhury, Angela Peace, Matthew J. Gray
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Predicting The Peak Bloom Of Yoshino Cherry Blossoms In Washington, Dc With Random Forest Regression, James Watkins, Ian Forde, Rene Salinas
Predicting The Peak Bloom Of Yoshino Cherry Blossoms In Washington, Dc With Random Forest Regression, James Watkins, Ian Forde, Rene Salinas
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Planarian Exposure To The Herbicide 2,4- Dichlorophenoxyacetic (2,4-D), Emily Pintilie, Alexis Galindez, Cassandra S. Korte
Planarian Exposure To The Herbicide 2,4- Dichlorophenoxyacetic (2,4-D), Emily Pintilie, Alexis Galindez, Cassandra S. Korte
Women in Science Conference
Poster presentation given at the 2025-26 Women in Science Conference in the Christine E Lynn University Center, 2nd floor, 240-241, held on Saturday, Nov. 8, 2025.
Bisphenol A Effects On Stress Behaviors, Alexis Galindez, Kevin Sosa, Emily Pintilie, Cassandra S. Korte
Bisphenol A Effects On Stress Behaviors, Alexis Galindez, Kevin Sosa, Emily Pintilie, Cassandra S. Korte
Women in Science Conference
Poster presentation given at the 2025-26 Women in Science Conference in the Christine E Lynn University Center, 2nd floor, 240-241, held on Saturday, Nov. 8, 2025.