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Stromal Fibroblastic Mutant Trp53 Promotes Mammary Tumor Development Via Enhanced Secretion Of Paracrine Factors, Bin Liu, Shunbin Xiong, Abie Williams-Villalobo, Gilda Chau, Yuan Qi, Hehua Chen, Carenza Johnson, Dhruv Chachad, Joy Mcdaniel, Xiaoping Su, Adel K El-Naggar, Guillermina Lozano, Yun Zhang Dec 2025

Stromal Fibroblastic Mutant Trp53 Promotes Mammary Tumor Development Via Enhanced Secretion Of Paracrine Factors, Bin Liu, Shunbin Xiong, Abie Williams-Villalobo, Gilda Chau, Yuan Qi, Hehua Chen, Carenza Johnson, Dhruv Chachad, Joy Mcdaniel, Xiaoping Su, Adel K El-Naggar, Guillermina Lozano, Yun Zhang

Faculty, Staff and Student Publications

Mutations in the tumor suppressor gene TP53 have been identified in breast cancer-associated fibroblasts and are associated with poor patient prognosis. However, the functional impact of fibroblastic mutant p53 on breast cancer development remains unclear. To investigate this, we compared female mice harboring HER2-driven mammary tumors with a fibroblast-specific Trp53 mutation (NP) to those with wild-type fibroblastic Trp53 (N). NP mice exhibited significantly shorter median tumor-free survival than N mice. RNA sequencing of NP and N tumors and mammary glands revealed numerous differentially expressed genes (DEGs) between tumors and the corresponding glands in both genotypes. Notably, the NP tumors showed …

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Measurable Imaging-Based Changes In Enhancement Of Intrahepatic Cholangiocarcinoma After Radiotherapy Reflect Physical Mechanisms Of Response, Brian De, Prashant Dogra, Mohamed Zaid, Dalia Elganainy, Kevin Sun, Ahmed M Amer, Charles Wang, Michael K Rooney, Enoch Chang, Hyunseon C Kang, Zhihui Wang, Priya Bhosale, Bruno C Odisio, Timothy E Newhook, Ching-Wei D Tzeng, Hop S Tran Cao, Yun S Chun, Jean-Nicholas Vauthey, Sunyoung S Lee, Ahmed Kaseb, Kanwal Raghav, Milind Javle, Bruce D Minsky, Sonal S Noticewala, Emma B Holliday, Grace L Smith, Albert C Koong, Prajnan Das, Vittorio Cristini, Ethan B Ludmir, Eugene J Koay Dec 2025

Measurable Imaging-Based Changes In Enhancement Of Intrahepatic Cholangiocarcinoma After Radiotherapy Reflect Physical Mechanisms Of Response, Brian De, Prashant Dogra, Mohamed Zaid, Dalia Elganainy, Kevin Sun, Ahmed M Amer, Charles Wang, Michael K Rooney, Enoch Chang, Hyunseon C Kang, Zhihui Wang, Priya Bhosale, Bruno C Odisio, Timothy E Newhook, Ching-Wei D Tzeng, Hop S Tran Cao, Yun S Chun, Jean-Nicholas Vauthey, Sunyoung S Lee, Ahmed Kaseb, Kanwal Raghav, Milind Javle, Bruce D Minsky, Sonal S Noticewala, Emma B Holliday, Grace L Smith, Albert C Koong, Prajnan Das, Vittorio Cristini, Ethan B Ludmir, Eugene J Koay

Faculty, Staff and Student Publications

Escalated doses of radiotherapy associate with improved local control and overall survival (OS) in intrahepatic cholangiocarcinoma (iCCA), but personalization remains limited because conventional size-based CT criteria correlate poorly with outcomes. We hypothesized that quantitative enhancement measurements would better predict clinical outcomes and guide individualized RT optimization. In a retrospective cohort of 154 patients, we analyzed pre- and post-RT CT scans using quantitative European Association for Study of Liver (qEASL) to derive viable tumor volumes, comparing enhancement-based metrics with size-based RECIST and linking them to outcomes via survival and mathematical modeling. Change in enhancement volume was strongly associated with OS after …

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How The Intake Of Pulses May Impact Metabolic Disorders And Dementia Risk: A Narrative Review, Lisa Michelle Belzer Salinas, Maricarmen Marroquin, Mariana Mendez, Isabel Omaña-Guzmán, Juan Carlos López-Alvarenga Dec 2025

How The Intake Of Pulses May Impact Metabolic Disorders And Dementia Risk: A Narrative Review, Lisa Michelle Belzer Salinas, Maricarmen Marroquin, Mariana Mendez, Isabel Omaña-Guzmán, Juan Carlos López-Alvarenga

Health & Biomedical Sciences Faculty Publications

We present a narrative review focusing on pulses’ geographical origin and distribution, their impact on human evolution and history, and their influence on human health. Pulses, including dry peas, beans, and lentils, are renowned for their richness in chemical antioxidants. Despite containing antinutrients, processing techniques preserve their health advantages. Epidemiological research has consistently demonstrated that the consumption of pulses is associated with favorable effects on metabolism. This evidence is further supported by molecular and clinical research, which has elucidated potential nutrigenomic mechanisms and effects on gut microbiota composition underlying their health benefits. However, the literature lacks randomized controlled clinical trials …

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The Effects Of Nanobubble Fertigation And Soil Conditioners To Improve Nutrient Dynamics, Soil Microbial Activity, And Chili Productivity, Betty Natalie Fitriatin, Euis Ahah Rokayah, Elsa Naila Elmyra, Tualar Simarmata, Nicky Oktav Fauziah, Hanif Fakhrurroja Dec 2025

The Effects Of Nanobubble Fertigation And Soil Conditioners To Improve Nutrient Dynamics, Soil Microbial Activity, And Chili Productivity, Betty Natalie Fitriatin, Euis Ahah Rokayah, Elsa Naila Elmyra, Tualar Simarmata, Nicky Oktav Fauziah, Hanif Fakhrurroja

Jurnal Kultivasi

Drip fertigation is a fertilization method that integrates nutrient delivery with an irrigation system, which is capable of optimizing the direct delivery of nutrients to the root zone. This experiment aims to investigate the effect of drip fertigation with nanobubble technology, and soil conditioners on the population of Phosphate-Solubilizing Bacteria (PSB) and Azotobacter spp., available phosphorus, total nitrogen, growth, and yield of red chili. The study used a Strip Plot Design with two factors and three replications. The first factor was nutrient application (solid NPK fertilizing as control; drip fertigation; and drip fertigation with nanobubble technology), and the second factor …

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Production Analysis Of Seed-Derived Tea Plants (Camellia Sinensis (L.) O. Kuntze) Across Two Different Seasons, Nurlita Rahmawati, Yudithia Maxiselly, Intan Ratna Dewi Anjarsari, Heri Syahrian Khomaeni, Gerry Renaldi, Agung Karuniawan Dec 2025

Production Analysis Of Seed-Derived Tea Plants (Camellia Sinensis (L.) O. Kuntze) Across Two Different Seasons, Nurlita Rahmawati, Yudithia Maxiselly, Intan Ratna Dewi Anjarsari, Heri Syahrian Khomaeni, Gerry Renaldi, Agung Karuniawan

Jurnal Kultivasi

Tea (Camellia sinensis (L.) O. Kuntze) is a major economic crop in Indonesia, yet its productivity is strongly influenced by environmental variability, particularly rainfall seasonality. Fluctuating yields under dry and wet conditions pose challenges for sustainable tea production. This study aimed to assess the effects of contrasting seasonal rainfall on seed-derived tea plants' yield and yield components. The research was conducted at a seed-derived tea plantation block in IRITC, West Java, across dry and wet seasons using field observations on tea yield, shoot proliferation, plucking quality, and environmental parameters. Statistical analyses included independent t-tests to compare seasonal differences and Pearson …

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Effect Of Nano Edible Coating, Storage Temperature, And Packaging On Water Content, Weight Loss, And Color On Oyster Mushrooms (Pleurotus Ostreatus), Inneke Amalia, Warid Ali Qosim, Kusumiyati Dec 2025

Effect Of Nano Edible Coating, Storage Temperature, And Packaging On Water Content, Weight Loss, And Color On Oyster Mushrooms (Pleurotus Ostreatus), Inneke Amalia, Warid Ali Qosim, Kusumiyati

Jurnal Kultivasi

Oyster mushrooms are one of the most commonly consumed mushrooms due to their high nutritional content, including protein, fiber, vitamins, and minerals, as well as their antioxidant properties. However, these mushrooms are easily damaged by microbes and poor post-harvest handling, which affects their quality. The combination of nano-edible coating, packaging, and storage temperature offers a solution to these issues. This study aims to evaluate the effects of nano-edible coating, packaging, and storage temperature on water content, weight loss, and the color (L*, a*, and b*) of oyster mushrooms. The study was conducted at the Horticulture Laboratory, Faculty of Agriculture, Universitas …

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Genomics Insights Into The Biogeography And Evolution Of Galapagos Iguanas Using Radseq And Wgseq Techniques, Cecilia Paradiso Dec 2025

Genomics Insights Into The Biogeography And Evolution Of Galapagos Iguanas Using Radseq And Wgseq Techniques, Cecilia Paradiso

Theses and Dissertations

The Galápagos archipelago is known for its unique endemic fauna shaped by isolation and geological dynamism. This thesis explores the evolutionary history of Galápagos iguanas, a monophyletic group comprising the marine iguana (Amblyrhynchus cristatus) and three land iguanas: Conolophus marthae, C. pallidus, and C. subcristatus. These species differ in distribu- tion, population size, and conservation status, with C. marthae classified as Critically Endan- gered due to its restricted range and small population. The main goal of this thesis is to fill knowledge gaps concerning the evolutionary trajectories, demographic histories, and genetic var- iability of Galápagos iguanas. The first chapter reconstructs …

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Study Of Insect Frass-Associated Microbiome On Plant Growth And Their Potential Use As Biofertilizer, Jasmine Sahota Dec 2025

Study Of Insect Frass-Associated Microbiome On Plant Growth And Their Potential Use As Biofertilizer, Jasmine Sahota

Theses and Dissertations

An increasing global food demand and the urgent need for sustainable agricultural practices have driven interest in insects as alternative feed and food sources. Insect frass, a by-product of insect rearing, represents a rich organic carbon source with diverse microbes that can enhance soil health and promote beneficial plant-microbe interactions. This study characterized the bacterial (16S-V4) and fungal (ITS2) microbiomes of frass from Black Soldier Fly (BSF) and Cricket species and evaluated their effects on maize (Zea mays) growth. Four frass variants were applied at rates of 56-280 kg ha⁻¹ in a pot experiment with untreated soil and mineral fertilizer …

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Revision And Biogeography Of The Tribulus Group (Orthoptera, Acrididae, Melanoplinae, Melanoplus) And Establishment Of The Rusticus Group With A Description Of Four New Species Of West Of Mississippi River, Usa, Jireh Mwamukonda Dec 2025

Revision And Biogeography Of The Tribulus Group (Orthoptera, Acrididae, Melanoplinae, Melanoplus) And Establishment Of The Rusticus Group With A Description Of Four New Species Of West Of Mississippi River, Usa, Jireh Mwamukonda

Theses and Dissertations

The genus Melanoplus represents one of the most diverse groups of acridid grasshoppers in North America, comprising over 430 described species within the subfamily Melanoplinae. Among its various species groups, the Tribulus group consists of flightless grasshoppers typically found in open woodlands and forest margins, primarily in the eastern United States. The Melanoplus tribulus group was first established by Blatchley (1920) as Obovatipennis Group. However, since species groups are informal taxonomic units not governed by nomenclatural rules, the group later became known as the Tribulus group. It currently includes 11 taxa. These brachypterous species occur from New Jersey south Florida …

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The Biology Of Green Antelopehorn Milkweed (Asclepias Viridis Walter) And Hemp Dogbane (Apocynum Cannabinum L.) And Response To Triclopyr Formulations And Other Auxin Herbicides, Kayla L. Broster Dec 2025

The Biology Of Green Antelopehorn Milkweed (Asclepias Viridis Walter) And Hemp Dogbane (Apocynum Cannabinum L.) And Response To Triclopyr Formulations And Other Auxin Herbicides, Kayla L. Broster

Theses and Dissertations

Studies were conducted in Oktibbeha and Clay Counties in Mississippi to determine the response of green antelopehorn milkweed and hemp dogbane to triclopyr and other auxin herbicides in non-cropland areas. These studies were conducted at four locations with well established populations for each species throughout 2020 to 2023, with applications repeated at each location the following year if populations persisted. Treatments included a high and low rate of each herbicide studied, with all four triclopyr formulations included for both species. Injury response data were collected two and four weeks after treatment and population density data were evaluated using individual stem …

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Trace Mineral Supplementation Strategies For Beef Cattle During Preconditioning And Feedlot Receiving, Madeline G. Mcknight Dec 2025

Trace Mineral Supplementation Strategies For Beef Cattle During Preconditioning And Feedlot Receiving, Madeline G. Mcknight

Theses and Dissertations

Beef cattle routinely undergo a variety of stressors within the preconditioning and feedlot receiving phases which may impair animal performance and health. Trace mineral supplementation, either through dietary or injectable sources, is proposed to mitigate these effects through metabolic and immune system support. Two systematic reviews and meta-analyses were conducted to evaluate the efficacy of two different oral supplementation methods, organic (OTM) and inorganic (INR), and injectable trace mineral (ITM) solutions on average daily gain (ADG) and morbidity. Across 20 studies, OTM supplementation increased ADG (P = 0.01) when compared to INR, but did not affect morbidity (P = 0.92). …

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Spatiotemporal Ecology Of Mycobacterium Ulcerans And Mycolactone Functions In French Guiana And Southeastern United States Aquatic Environments, Magdalene Dogbe Dec 2025

Spatiotemporal Ecology Of Mycobacterium Ulcerans And Mycolactone Functions In French Guiana And Southeastern United States Aquatic Environments, Magdalene Dogbe

Theses and Dissertations

Mycobacterium ulcerans, the causative agent of Buruli ulcer, produces mycolactone, a polyketide toxin traditionally studied for its role in human pathogenesis. This dissertation presents a comprehensive spatiotemporal analysis of M. ulcerans and mycolactone producing mycobacteria (MPM) ecology in the Americas and also reveals mycolactone's role in the environment as a microbial community regulator. Through comparative studies in French Guiana (endemic) and the southeastern United States (non-endemic), combined with experimental microcosm investigations, this research contributes to environmental pathogen ecology understanding. Environmental surveillance across 2,226 samples from French Guiana revealed complete MPM restriction to freshwater environments, with zero detections from 1,226 coastal …

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Evaluating The Effects Of Biostimulants On Apple Coloration, Patrick G. Owens Dec 2025

Evaluating The Effects Of Biostimulants On Apple Coloration, Patrick G. Owens

Theses and Dissertations

Apple peel color is one determining factor of apple quality and is a highly sought after trait by both growers and consumers. Historically plant growth regulators (PGRs) such as daminozide and auxins have been used to induce a greater amount of red color in the peel, but these products typically have negative production impacts and raise environmental concerns. One new area of interest is in called biostimulants. This study investigated the effects of two experimental biostimulants (MCEN1 and MCEN2) applied at varying rates and timings, as well as a commercially available plant growth regulator (Blush® 2X), on ‘Honeycrisp’ apple color …

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Validation And Efficacy Of A Novel External Ankle Support Device For The Prevention Of Lateral Ankle Sprains, Sally Kennon Barfield Dec 2025

Validation And Efficacy Of A Novel External Ankle Support Device For The Prevention Of Lateral Ankle Sprains, Sally Kennon Barfield

Theses and Dissertations

Ankle sprains are a common injury in sports and in life and can lead to debilitating consequences if not managed properly. Current prevention methods are limited to bracing or taping of the ankle. While these methods have been shown to help in mitigation of ankle sprains, associated issues such as performance decrements and discomfort have been noted in the currently available literature. The BetterGuards is a novel external ankle support that has been touted as the key to the issues presented by more traditional prevention methods. The purpose of this study was to determine both the effectiveness of the BetterGuards …

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Fitness Changes, Dietary Practices And Sleep Quality In Non-Elite Through-Hikers: A Case Series, Cory J. Greever, Blayke Harrison, Holland Gaston, Anna Grexton, Dante Argento Dec 2025

Fitness Changes, Dietary Practices And Sleep Quality In Non-Elite Through-Hikers: A Case Series, Cory J. Greever, Blayke Harrison, Holland Gaston, Anna Grexton, Dante Argento

Topics in Exercise Science and Kinesiology

Topics in Exercise Science and Kinesiology Volume 6: Issue 1, Article 13, 2025. Through-hikes on long distance backpacking routes have the potential to both improve physical fitness and pose health risks. PURPOSE: To quantify changes in cardiorespiratory fitness and body composition, while recording dietary intake and sleep habits in a sample of through-hikers. METHODS: Participants completed two lab visits consisting of a maximal graded treadmill test and body composition assessments. Hiking volume, energy expenditure, sleep duration, and sleep staging were estimated during the hike using a smart watch. Participants kept a journal of all food and beverage intake. RESULTS: Over …

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Knee Injury Prevention Program In An Early Pubertal Female Athlete During A Recreational Softball Season, Doug W. Dendy, Toby Brooks, C Roger James, Micah Lierly Dec 2025

Knee Injury Prevention Program In An Early Pubertal Female Athlete During A Recreational Softball Season, Doug W. Dendy, Toby Brooks, C Roger James, Micah Lierly

Topics in Exercise Science and Kinesiology

Topics in Exercise Science and Kinesiology Volume 6: Issue 1, Article 12, 2025. This case study was intended to analyze the impact of a knee injury prevention program (KIPP) for a young female athlete in a short recreational softball season. It was hypothesized that initiating a KIPP early within a recreational sports season would positively alter lower extremity biomechanics, subsequently reducing the risk of knee injuries during and after skeletal development. During a recreational softball season, a 13-year-old female athlete completed a preliminary biomechanical test, the drop vertical jump battery (DVJBpre), underwent a 7-week in-season KIPP, then was …

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Influence Of Urbanization On Diel Activity Patterns Across Seasons For Four Mesocarnivore Species Along An Urban-To-Rural Gradient Through Boston, Massachusetts, Myra M. Goes Dec 2025

Influence Of Urbanization On Diel Activity Patterns Across Seasons For Four Mesocarnivore Species Along An Urban-To-Rural Gradient Through Boston, Massachusetts, Myra M. Goes

Honors Program Theses and Projects

Urbanization is a growing threat to wildlife and poses unique challenges that animals must overcome to thrive in developed places. Temporal partitioning is one method that wildlife may employ to persist among the increased predation, competition, and human presence pressures of urban spaces. To evaluate diel patterns of mesocarnivores along an urban-to-rural (URG) gradient, data were utilized from camera traps established at 27 sites along a URG in southeastern Massachusetts as part of the Urban Wildlife Information Network (UWIN). Camera trap photos from summer and winter between 2023 to 2025 were used and filtered for coyote (Canis latrans), northern raccoon …

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Reducing Foodborne Bacteria Public Health Burden By Novel Compounds And Pressure-Based Technologies, Junice Alannah Sibley Dec 2025

Reducing Foodborne Bacteria Public Health Burden By Novel Compounds And Pressure-Based Technologies, Junice Alannah Sibley

Tennessee State University Alumni Theses and Dissertations

Food safety strategies are being developed in the hopes of combating foodborne pathogens and their risks. Previous techniques and technologies are struggling to meet the needs of the public, leading to the demand for new, innovative methods. Mild high-pressure processing (HPP) of 350 MPa was used in a synergetic combination with mild heat of 60°C and the antimicrobial carvacrol for the decontamination of non-typhoidal Salmonella serovars that resulted in a >5 log CFU/mL reduction. Additionally, a secondary study was conducted comparing a single Salmonella Tennessee strain with a 4-strain Salmonella cocktail to examine sensitivity to pressure-based treatments resulting in a …

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Acid And Sequential Acid–Alkali Extraction To Mitigate Enzyme Activity And Off-Flavors In Chickpea Protein: Implications On Structural, Functional, And Bioactive Properties, Kavitha Lakshmipathy, Sukanya Poddar, Nikitha Modupalli, Scott Lafontaine, Md Mahfuzur Rahman Dec 2025

Acid And Sequential Acid–Alkali Extraction To Mitigate Enzyme Activity And Off-Flavors In Chickpea Protein: Implications On Structural, Functional, And Bioactive Properties, Kavitha Lakshmipathy, Sukanya Poddar, Nikitha Modupalli, Scott Lafontaine, Md Mahfuzur Rahman

Food Science Faculty Publications and Presentations

Chickpea proteins offer significant nutritional and functional benefits in food products; however, their utilization is often restricted by off-flavors, primarily for lipoxygenase (LOX) and lipase activity. This study aims to develop a novel extraction method by combining acid (pH 2.0) extraction with the conventional alkali (pH 9.0) method to inactivate enzymes and enhance protein quality. Acid-extracted proteins exhibit the highest purity (83.4%), albumin content, and structural flexibility (46.65% random coil). Both acid and sequential acid-alkali-extracted proteins significantly reduced LOX (0.75 and 0.88 U/g) and lipase (0.10 and 0.08 U/g) activity. Acid extraction significantly lowers volatile compounds such as hexanal (0.0409 …

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Role Of Cellular Stress Responses In Innate Immune Defense Against Acute Respiratory Infections, Amit Sharma Dec 2025

Role Of Cellular Stress Responses In Innate Immune Defense Against Acute Respiratory Infections, Amit Sharma

LSU Doctoral Dissertations

The endoplasmic reticulum (ER) stress sensor inositol-requiring enzyme 1α (IRE1α) is an important regulator of innate immune cells. However, its role in pulmonary innate host defenses remains poorly understood. This dissertation elucidates the dual, context-dependent role of IRE1α in host defense against methicillin-resistant Staphylococcus aureus (MRSA) pneumonia. We demonstrate IRE1α’s function as both a detrimental mediator of acute pathology and an essential facilitator of innate immune memory. Our work revealed that acute IRE1α activation during primary MRSA infection is detrimental. In lungs and alveolar macrophages (AMs), IRE1α is activated in response to MRSA infection. Consequently, IRE1α activation triggers a hyperinflammatory …

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The Role Of Toll-Like Receptors In Tributyltin, Dibutyltin, And Pentachlorophenol Stimulation Of Tumor Necrosis Factor Alpha Production By Human Immune Cells, Latoya Michelle Daniel Dec 2025

The Role Of Toll-Like Receptors In Tributyltin, Dibutyltin, And Pentachlorophenol Stimulation Of Tumor Necrosis Factor Alpha Production By Human Immune Cells, Latoya Michelle Daniel

Tennessee State University Alumni Theses and Dissertations

Tributyltin (TBT), Dibutyltin (DBT), and Pentachlorophenol (PCP) are persistent environmental contaminants that have been shown to increase immune-cell production of pro-inflammatory cytokines and thus have the capacity to cause chronic inflammation and its associated pathologies such as cancer, cardiovascular disorders, and autoimmune conditions. TBT has been detected in human blood at concentrations up to 260 nM, DBT up to 0.3 µM, and PCP between 0.15 and 5 µM. Tumor necrosis factor-alpha (TNF-α) is a pro-inflammatory cytokine produced by immune cells in response to pathogen- or damage-associated molecular patterns (PAMPs/DAMPs) via Toll-like receptors (TLRs). Dysregulated TNF-α production contributes to chronic inflammatory …

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Genetics Of Aluminum Tolerance And Diversity In United States Vigna Unguiculata Germplasm, Max Carl Miller Dec 2025

Genetics Of Aluminum Tolerance And Diversity In United States Vigna Unguiculata Germplasm, Max Carl Miller

Tennessee State University Alumni Theses and Dissertations

Cowpea (Vigna unguiculata L. Walp) is an annual legume of immense importance across the world. However, knowledge of its ability to tolerate aluminum (Al) at toxic levels is not as comprehensive. This stress is an issue globally and especially in the southeastern United States, which has many Al-toxic soils. Here we determined multiple cultivars both tolerant and susceptible to Al toxicity. This was expounded upon by employing RNA sequencing on two cultivars from the United States with significantly different tolerance levels to characterize genes and pathways associated with Al toxicity and response. Multiple well-established gene orthologs like STOP, STAR, and …

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Impact Of Cover Crops On Soil Hydraulic Properties And Water Dynamics, Sabin Shrestha Dec 2025

Impact Of Cover Crops On Soil Hydraulic Properties And Water Dynamics, Sabin Shrestha

Tennessee State University Alumni Theses and Dissertations

Cover cropping has emerged as a climate adaptation strategy in sustainable agriculture to enhance agroecosystem resilience against weather extremes such as floods, droughts, and erratic rainfall patterns. But how well cover crops (CCs) can buffer crop yields against weather variability depends on their ability to regulate improvements in soil hydrology. Through a global meta-analysis of 1007 pairwise observations from 146 studies spanning across 34 countries, we investigated the overall effects of CCs on six key soil hydraulic properties and further examined how environmental and management factors moderate these overall responses. Results showed that CCs significantly improved total porosity by 7.7%, …

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Agronomic Management Practices For Cbd And Fiber Hemp In Southeastern United States, Anand Kumar Dec 2025

Agronomic Management Practices For Cbd And Fiber Hemp In Southeastern United States, Anand Kumar

Tennessee State University Alumni Theses and Dissertations

The farm bill of 2014 and 2018 legalized hemp (Cannabis sativa L.) production for cannabidiol (CBD), grain, and fiber uses in the U.S. Agronomic management practices for floral hemp for CBD production were not well studied. To optimize the agronomic management practices for high CBD content and THC concentration below the compliance level of 0.3% on a dry weight basis requires specific management and adaptability. A two-year field study was conducted at the Tennessee State University Agricultural Research and Education Center (TSU AREC) in Nashville, Tennessee, to evaluate two production systems, the Non-Chemical System (NCS) and the Chemical-Based System (CBS), …

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Tennessee’S Green Industry: An Economic Impact Assessment, Savannah R. Lewis Dec 2025

Tennessee’S Green Industry: An Economic Impact Assessment, Savannah R. Lewis

Tennessee State University Alumni Theses and Dissertations

This study estimates the economic contributions of the greenhouse and nursery industry, commonly known as the "green industry," in Tennessee for 2023. Utilizing data on employment, labor income, value added, and industry output, alongside economic multipliers generated from the Input-Output modeling software, IMPLAN (Impact Analysis for Planning), we provide a comprehensive analysis of the green industry's impact on the state's agricultural economy. The findings are presented in 2025 dollars, highlighting the industry's significance for informing future policy decisions. The primary objectives were to assess total contributions at the state, regional, and county levels. Direct employment across all sectors was estimated …

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Exploring The Autofermented Cyanobacterial Crude Extract As Antimicrobial Animal Feed Additives., Mohana Krishnan Neelakrishnan Dec 2025

Exploring The Autofermented Cyanobacterial Crude Extract As Antimicrobial Animal Feed Additives., Mohana Krishnan Neelakrishnan

Tennessee State University Alumni Theses and Dissertations

Overexploitation of antibiotics in the animal industry has driven the need for reduced usage, but this reduction has intensified the challenge posed by Salmonella enterica and Campylobacter jejuni to livestock systems and public health. This situation underlines the need for sustainable antimicrobial alternatives. Although cyanobacteria are promising in this respect, since they may produce a variety of bioactive metabolites, the amounts of these metabolites in their natural state are insufficient to elicit potent antibacterial action. In this study, autofermentation was investigated as a means of enhancing antibacterial efficacy in Fischerella ambigua and Nostoc muscorum by promoting the synthesis of organic …

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Structural Basis Of Panx1 Permeation And Positive Modulation By Mefloquine, Yangyang Li, Zheng Ruan, Junuk Lee, Ian Orozco, Edward Zhou, Juan Du, Wei Lü Dec 2025

Structural Basis Of Panx1 Permeation And Positive Modulation By Mefloquine, Yangyang Li, Zheng Ruan, Junuk Lee, Ian Orozco, Edward Zhou, Juan Du, Wei Lü

Department of Biochemistry and Molecular Biology Faculty Papers

Purinergic signaling relies on ATP release through exocytosis and large-pore channels. Large-pore channels permeate both small anions like chloride and large signaling molecules like ATP, but how this broad cargo selectivity is structurally controlled remains elusive. Here we investigate PANX1, a prototypical large-pore channel, and uncover structural plasticity at the extracellular entrance formed by seven tryptophan (W74) residues. The W74 sidechains are flexible, sampling conformations that range from a constricted state permissive only to chloride to a dilated state compatible with ATP. These states are coupled to variable cation-π interactions between W74 and arginine 75 (R75), suggesting a mechanism for …

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Acute Effects Of Multi-Joint Eccentric Exercise On Lower-Extremity Muscle Activation Measured During Land And Water Walking, Brayden Worley, Brennan J. Thompson, Jon Carey, Talin Louder Dec 2025

Acute Effects Of Multi-Joint Eccentric Exercise On Lower-Extremity Muscle Activation Measured During Land And Water Walking, Brayden Worley, Brennan J. Thompson, Jon Carey, Talin Louder

Kinesiology and Health Science Student Research

Falls are a leading cause of injury and loss of independence in older adults, often linked to deficits in lower-limb muscle function and gait mechanics. Eccentric exercise can improve muscular resilience, while aquatic walking offers a safe, supportive environment to retrain gait; however, little is known about how these modalities interact at the neuromuscular level. This study compared lower-limb muscle activation during gait on land and in water, before and after an acute bout of eccentric exercise, in healthy young adults. Surface electromyography was collected from the tibialis anterior (TA), gastrocnemius medialis (GM), vastus lateralis (VL), and biceps femoris (BF) …

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The Chemistry Of Color: A Comparative Analysis Of Natural And Synthetic Dyes In Textile Application, Caitlyn Pinaga Cpht Dec 2025

The Chemistry Of Color: A Comparative Analysis Of Natural And Synthetic Dyes In Textile Application, Caitlyn Pinaga Cpht

Honors Program Theses and Research Projects

The Chemistry of Color: A Comparative Analysis of Natural and Synthetic Dyes in Textile Application examines how color functions at the intersection of chemistry, culture, and environmental responsibility. This project traces the evolution of dyeing from ancient natural pigment traditions, rooted in ecological knowledge, agricultural practices, and cultural identity, to the industrial rise of synthetic dyes, whose laboratory precision enabled unprecedented consistency, brightness, and global textile expansion. Through experimental swatch analysis, the study compares the behavior of natural dyes derived from plants and food sources with modern fiber-reactive and synthetic dye classes on a range of fibers including cotton, bamboo …

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Development Of Microcrystalline Tests For Fentanyl, Clonazepam, And Diazepam Identification, Karis French Dec 2025

Development Of Microcrystalline Tests For Fentanyl, Clonazepam, And Diazepam Identification, Karis French

Honors Projects

Microcrystalline tests are chemical tests that involve the mixing of a substance with a specific reagent resulting in the formation of a crystal structure. Currently, microcrystalline tests are used as presumptive tests in forensic drug chemistry laboratories to provide the suspected identity of unknown substances. There is, however, a limited amount of research on this use of microcrystalline structures. Additionally, this existing research is outdated and does not include some of the newer commonly encountered controlled substances including fentanyl, clonazepam, and diazepam. This literature-based review attempts to identify reagents that could be used in microcrystalline tests for the identification of …

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