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Articles 6001 - 6030 of 256627
Full-Text Articles in Entire DC Network
Evaluating Donor Site Recovery Following Halodule Wrightii Harvest For Restoration In Northwest Florida, Katie M. Konchar, Becca A. Hatchell, Colin P. Shea, Bradley T. Furman, Kent Smith
Evaluating Donor Site Recovery Following Halodule Wrightii Harvest For Restoration In Northwest Florida, Katie M. Konchar, Becca A. Hatchell, Colin P. Shea, Bradley T. Furman, Kent Smith
Gulf and Caribbean Research
Bare‑root harvesting of Halodule wrightii is widely used to supply donor material for seagrass restoration, yet the capacity of donor meadows to recover in near‑temperate systems remains poorly documented. We evaluated donor‑site recovery following bare‑root harvesting in St. Andrew Bay, northwest Florida—an estuary at the northern extent of Tropical Atlantic Bioregion 2 where H. wrightii exhibits strong seasonal senescence and a shortened growing season. Thirty harvest impact sites were monitored for 388 days to quantify changes in shoot density, percent frequency, and sediment elevation relative to nearby reference conditions. Shoot density and percent frequency at harvested sites converged with reference …
Health And Nutrition In The First 1000 Days Of Life, Yaojiang Shi, Qi Zhang, Yiliang Zhu, Jingchun Nie
Health And Nutrition In The First 1000 Days Of Life, Yaojiang Shi, Qi Zhang, Yiliang Zhu, Jingchun Nie
Health Behavior, Policy & Management Faculty Publications
Malnutrition and health issues remain persistent global crises, with developing regions bearing the brunt of the burden. According to the World Health Organization, nearly half of under-five deaths in low-and middle-income countries are linked to malnutrition, while stunting, wasting, and micronutrient deficiencies impair the development of millions of children annually. The studies in this special issue focus on countries facing distinct yet interconnected challenges: Sub-Saharan African nations grapple with high rates of stunting and maternal high-risk fertility behaviors; China confronts rural-urban disparities in dietary diversity and grandparenting practices; Colombia struggles with intersectional inequalities driving infant mortality; and Zambia faces unique …
Advancing Food Equity Through Explainable Ai (Xai): Identifying Place-Based Factors And Conditions Of Food Security, Leslie Hoglund, Hyoshin Park
Advancing Food Equity Through Explainable Ai (Xai): Identifying Place-Based Factors And Conditions Of Food Security, Leslie Hoglund, Hyoshin Park
Health Behavior, Policy & Management Faculty Publications
Food behaviors, food security, and their association with socioeconomic factors constitute a critical area of study with implications for public health, economic stability, and social equity. Understanding these relationships are essential for developing effective policies and interventions that promote sustainable, healthy food systems and greater food equity. This paper employs explainable artificial intelligence (XAI) methods to identify key features influencing household food behaviors. The insights gained from the XAI analysis are further utilized in conjunction with inverse reinforcement learning (IRL) to examine expert behaviors related to eating habits satisfaction. The XAI results reveal that household health conditions, spending patterns, and …
Association Between A Lifestyle Medicine Score And Stroke In U.S. Adults With Hyperglycemia: 2007- 2010 Nhanes, Swarnima Naithani
Association Between A Lifestyle Medicine Score And Stroke In U.S. Adults With Hyperglycemia: 2007- 2010 Nhanes, Swarnima Naithani
UNF Graduate Theses and Dissertations
The relationship between glycemic control and cardiovascular disease (CVD) is well- established, however, lifestyle modifications to prevent CVD warrant further investigation. Purpose: This study aimed to evaluate the relationship between adherence to the six lifestyle medicine pillars promoted by the American College of Lifestyle Medicine and stroke in U.S. adults with hyperglycemia. A lifestyle medicine composite score (LMS) was developed to quantify adherence with the hypothesis that a higher LMS (greater adherence to lifestyle recommendations) correlates with lower odds of stroke in adults with hyperglycemia. Methods: The study sample (n=2,079) included adult (≥ 40 years of age) participants in the …
A Polyphasic Investigation Of Terrestrial Green Algal Diversity Of Biological Soil Crusts From The California Channel Islands, Emily Masluk
A Polyphasic Investigation Of Terrestrial Green Algal Diversity Of Biological Soil Crusts From The California Channel Islands, Emily Masluk
Masters Theses
Biological soil crusts (BSCs) in arid and semiarid environments support diverse microbial communities that contribute to soil stabilization, nutrient cycling, and ecosystem resilience. Among these organisms, terrestrial green algae are taxonomically challenging due to their simple morphology, phenotypic plasticity, and lack of diagnostic life history traits. This study investigated the diversity and taxonomy of green algae from BSCs collected on San Nicolas Island, San Clemente Island, and Santa Barbara Island using the polyphasic approach integrating morphology, phylogenetic analyses, molecular analyses, and ecological data. A total of 198 strains were isolated, of which 79 green algal strains underwent molecular analysis using …
Complex Cyanobacteria Biopriming Effects On The Growth Of Mojave Desert Restoration Plant Species At Differing Life Stages, Ashley R. Brumit
Complex Cyanobacteria Biopriming Effects On The Growth Of Mojave Desert Restoration Plant Species At Differing Life Stages, Ashley R. Brumit
Masters Theses
Seeding practices are an important tool for land managers to restore habitats following disturbances, but large-scale seeding efforts often fail. One option is to bioprime seeds with native microorganisms such as cyanobacteria. However, biopriming studies have yet to be conducted in American deserts, and only one previous study compared the effects of heterocystous and non-heterocystous cyanobacteria biopriming. The objective of my work was to evaluate the effects of seed biopriming on plant growth of Mojave Desert plant species and comparing the effect ofN-fixing and non N-fixing cyanobacteria. One heterocystous taxon (Kalymmatonema desertorum) and one non-heterocystous taxon (Microcoleus sp.) isolated from …
From Molecules To Minds: Integrative Multi-Omics In Psychiatry, Hossein Abbasi, Sage E. Hawn, Arash Javanbakht, Soraya Seedat, Kyle Bourassa, Sinead M. Sinnott, Antonia V. Seligowski, Sian Hemmings, Nathan A. Kimbrel, Alicia K. Smith, Leslie Brick, Divya Mehta
From Molecules To Minds: Integrative Multi-Omics In Psychiatry, Hossein Abbasi, Sage E. Hawn, Arash Javanbakht, Soraya Seedat, Kyle Bourassa, Sinead M. Sinnott, Antonia V. Seligowski, Sian Hemmings, Nathan A. Kimbrel, Alicia K. Smith, Leslie Brick, Divya Mehta
Psychology Faculty Publications
Psychiatric disorders are biologically complex conditions arising from interactions across genomic, epigenomic, transcriptomic, proteomic, metabolomic, and metagenomic layers. Single-omics approaches rarely capture more than a fraction of the variance in complex conditions, underscoring the importance of integrative multi-omics frameworks. This mini-review summarizes key methodologies and their application in psychiatric research, with a focus on systems-level integration of genomic risk scores, transcriptomic networks, and neuroimaging data to advance biological understanding of disorders such as depression, schizophrenia, and Alzheimer’s disease. We also outline the infrastructural requirements for effective multi-omics research, including standardized biobanking, Laboratory Information Management Systems, adherence to FAIR data principles, …
Examining The Factor Structure And Subgroup Invariance Of The Deliberate Denial Of Disordered Eating Behaviors Scale, Lindsay Howard, Sage Hawn, Kayla D. Pitchford, Riley Mcgrath, Aubri Farniok, Arturo Sesma, Kristin E. Heron
Examining The Factor Structure And Subgroup Invariance Of The Deliberate Denial Of Disordered Eating Behaviors Scale, Lindsay Howard, Sage Hawn, Kayla D. Pitchford, Riley Mcgrath, Aubri Farniok, Arturo Sesma, Kristin E. Heron
Psychology Faculty Publications
The denial, concealment, or omission of disordered eating behaviors has received limited attention in the eating disorder literature, partly due to the lack of reliable and valid measures. This study re-examined the factor structure of the Denial of Disordered Eating Behaviors Scale (DDEBS-12) and tested measurement invariance across gender identity, racial identity, and levels of disordered eating in a non-clinical undergraduate sample (N = 3285). Confirmatory factor analyses did not support the original unidimensional structure. Instead, a seven-item model assessing denial of dietary restriction demonstrated the best fit and was renamed the DDEBS-restriction. The revised scale showed good internal consistency …
Best Practices For Using Biological Data In Psychological Research, Sage E. Hawn, Sinead M. Sinnott, Alicia K. Smith, Kyle Bourassa, Leslie Brick, Sian Hemmings, Soraya Seedat, Arash Javanbakht, Lauren Smith, Antonia V. Seligowski, Nathan A. Kimbrel, Divya Mehta, Hossein Abbasi, Erika Wolf
Best Practices For Using Biological Data In Psychological Research, Sage E. Hawn, Sinead M. Sinnott, Alicia K. Smith, Kyle Bourassa, Leslie Brick, Sian Hemmings, Soraya Seedat, Arash Javanbakht, Lauren Smith, Antonia V. Seligowski, Nathan A. Kimbrel, Divya Mehta, Hossein Abbasi, Erika Wolf
Psychology Faculty Publications
Advances in statistical techniques for analyzing biological data have driven the need for larger sample sizes, which are ultimately made possible through team science efforts. Findings from these efforts have led to a significant shift in approaches to biological data collection over the past decade, from traditional approaches relying on single measures or assays collected by individual investigators in small lab-based studies to high-dimensional methodologies embedded within large cohorts or multi-site studies. These recent large scale consortium efforts necessitate careful consideration across the full data pipeline, from pre-data generation and sample collection to processing and statistical analysis, while addressing challenges …
Differing Circulating Microrna Profiles Of Long-Lived Polish Populations, Fabrizzio Lijeron-Herrera
Differing Circulating Microrna Profiles Of Long-Lived Polish Populations, Fabrizzio Lijeron-Herrera
Honors Undergraduate Theses
Exceptional longevity, defined as a lower biological age relative to chronological age and maintenance of functional capacity or a slowing of functional decline, is a phenotype most readily observed in centenarians and nonagenarians. These individuals exhibit a phenomenon known as compressed morbidity, spending substantially less time in poor health compared to younger elderly populations, thus representing a unique human model of delayed aging. Circulating microRNAs (miRNAs), potent post-transcriptional regulators of molecular pathways, have emerged as important modulators of aging-related pathways; however, no study has comprehensively profiled miRNAs from serum in long-lived individuals from Central Europe. In particular, Polish populations present …
The Role Of The Amygdala In Huntington Disease-Associated Aggression, Luis Torres
The Role Of The Amygdala In Huntington Disease-Associated Aggression, Luis Torres
Honors Undergraduate Theses
Huntington disease (HD) is a fatal neurodegenerative disorder caused by a trinucleotide CAG expansion in the huntingtin gene (HTT). HD is characterized by motor, cognitive, and psychiatric symptoms that significantly impact patient and caregiver quality of life. Psychiatric symptoms, including depression, anxiety, and irritability, are common manifestations of HD and can emerge years before the onset is clinically diagnosed. Aggression is a common and challenging psychiatric symptom in HD, often misunderstood and associated with caregiver stress, early institutionalization, and reduced quality of life. Despite its clinical impact, aggression in HD lacks effective, targeted treatment options. Similar to HD …
Monograph Available: Best Practices For Managing Human–Beaver Conflicts In North America: Balancing Ecological Benefits And Human Interests
Human–Wildlife Interactions
This is an announcement about the published monograph titled "Best Practices for Managing Human–Beaver Conflicts in North America: Balancing Ecological Benefits and Human Interests." This publication, part of the HWI Monograph Series, is online and open access.
Perceived Barriers To Physical Activity And Campus Recreation Facility Usage In College Students Referred Or Not Referred To An Exercise Is Medicine® On Campus Program, Benjamin M. Colbert
Perceived Barriers To Physical Activity And Campus Recreation Facility Usage In College Students Referred Or Not Referred To An Exercise Is Medicine® On Campus Program, Benjamin M. Colbert
Theses and Dissertations
INTRODUCTION: Approximately 36-50% of college students are inactive and report numerous barriers to being physically active. Physical activity (PA) barriers are any obstacle an individual believes affects their PA participation. Individuals who perceive more barriers are less likely to participate in PA and as such, interventions that target barriers may increase PA participation. Exercise is Medicine® on Campus (EIM-OC) is one intervention that may improve PA levels on college campuses by reducing barriers. The purpose of this study was to document PA and campus recreation facility barriers in university students and examine the influence of an individualized EIM-OC intervention …
Comparative Analysis Of Six New Chloroplast Genomes In Platanthera (Orchidaceae) Enhances Understanding Of Its Diversification, Lisa E. Wallace, Martin I. Batalla, Matthew Maisonave
Comparative Analysis Of Six New Chloroplast Genomes In Platanthera (Orchidaceae) Enhances Understanding Of Its Diversification, Lisa E. Wallace, Martin I. Batalla, Matthew Maisonave
Biological Sciences Faculty Publications
Platanthera is among the most diverse genera of orchids in north temperate regions, with high species diversity in Asia and North America. Despite many ecological studies in this group, little is known about its genomic diversity. Here, we report the newly annotated chloroplast genomes from six species in subgenus Limnorchis from North America and compare them with plastomes published for Platanthera species from Asia and Europe. We found that the plastomes of species in subg. Limnorchis are among the smallest reported for Platanthera thus far. While major structural differences were not detected in the newly sequenced species, ndh genes were …
Effect Of Substrate Dispersion Method And Particle Size On In Vitro Digestibility, Gas Production Kinetics And Composition, And Fermentation Characteristics In Different Feed Types, Luiz C. O. Sousa, Ellem M. A. Matos, Ronald J. Trotta, Edenio Detmann, David L. Harmon
Effect Of Substrate Dispersion Method And Particle Size On In Vitro Digestibility, Gas Production Kinetics And Composition, And Fermentation Characteristics In Different Feed Types, Luiz C. O. Sousa, Ellem M. A. Matos, Ronald J. Trotta, Edenio Detmann, David L. Harmon
Animal and Food Sciences Faculty Publications
Our objective was to evaluate the influence of substrate dispersion method and particle size on in vitro digestibility, gas production kinetics and composition, and fermentation characteristics of different feed types. Alfalfa hay, tall fescue hay, ground corn, soybean meal, and a total mixed ration (TMR) were used as substrates. Treatments were designed according to a 2 × 2 × 5 factorial arrangement: two substrate dispersion methods (loose substrate and in filter bags), two particle sizes (1 mm and 2 mm), and five feeds. Filter bags decreased (P ≤ 0.001) digestibility and gas production compared with loose samples. Filter bags decreased …
Menstrual Cycle Phase Effects On Alcohol-Impaired Driving Performance And Risk Awareness, Annie K. Griffith
Menstrual Cycle Phase Effects On Alcohol-Impaired Driving Performance And Risk Awareness, Annie K. Griffith
Theses and Dissertations--Psychology
Growing evidence indicates that risky behavior among women is elevated during the late follicular phase of the menstrual cycle, likely due to increased estradiol levels. Furthermore, alcohol-induced impairment of women’s inhibitory control is significantly greater during the late versus early follicular phase. Consequently, cycle phase may influence outcomes of poor inhibitory control while intoxicated, such as alcohol-impaired driving. Alcohol-impaired driving risk manifests in two ways: risk-taking while driving, and risk awareness regarding the decision to drive. This dissertation tested the hypothesis that alcohol-induced increases in driver risk-taking and decreases in risk awareness would be exacerbated during the late versus early …
Daily Rhythms In Psychosocial Stress, Sleep, And Mood: A Multimethod Approach To Transdiagnostic Psychopathology Risk And Intervention, Gabriel Gilmore
Daily Rhythms In Psychosocial Stress, Sleep, And Mood: A Multimethod Approach To Transdiagnostic Psychopathology Risk And Intervention, Gabriel Gilmore
Theses and Dissertations--Psychology
Rhythms are central to nearly every core physiological and psychological process and have profound influences on overall health and well-being, particularly in the context of mood disorders. This dissertation emphasizes a rhythm-centered framework for understanding transdiagnostic psychopathology, proposing that the temporal organization of psychosocial stress, sleep, and mood provides crucial information for the development and treatment of mood disorder symptomology. Current literature relies primarily on mean symptom levels, overlooking day-to-day patterns in psychosocial experiences. To address this key methodological gap, three studies are examined. Study 1 develops and validates the Psychosocial Stress Regularity Measure (PSRM), a brief single-item measure of …
Dwarf Tomato Cultivar Selection Guide, Abigail Lazier, Noah Langenfeld
Dwarf Tomato Cultivar Selection Guide, Abigail Lazier, Noah Langenfeld
Plants, Soils and Climate Student Research
This cultivar guide provides information on eighteen dwarf tomato cultivars grown at Utah State University. The goal is to help growers compare varieties based on plant size, productivity, fruit characteristics, and quality. Each cultivar profile includes a photograph of the plant along with key information on growth habit, size classification, yield, fruit size, and soluble solids (°brix). Whether you are selecting tomatoes for a patio, indoor garden, greenhouse, or other space-limited growing system, this guide offers an easy-to-use resource for identifying cultivars that best match your available space and production goals.
Biphasic Calcium Disturbance In Rhabdomyolysis: A Case Report Of Recovery Phase Severe Hypercalcemia, Maham Shahid, Jean C. Ramos-Cardona, Maria Toustsoglou, Gunjan Y. Gandhi
Biphasic Calcium Disturbance In Rhabdomyolysis: A Case Report Of Recovery Phase Severe Hypercalcemia, Maham Shahid, Jean C. Ramos-Cardona, Maria Toustsoglou, Gunjan Y. Gandhi
South Atlantic Division GME Research Days 2026
No abstract provided.
Gastrointestinal Symptoms Associated With Sodium Bicarbonate Supplementation Protocols: A Systematic Review, Ian P. Winter, Paul Sarac, Patrick B. Wilson
Gastrointestinal Symptoms Associated With Sodium Bicarbonate Supplementation Protocols: A Systematic Review, Ian P. Winter, Paul Sarac, Patrick B. Wilson
Exercise Science Faculty Publications
Sodium bicarbonate positively impacts performance, but its associated gastrointestinal symptoms (GIS) may limit use. This systematic review synthesized literature that has evaluated GIS with sodium bicarbonate supplementation. Literature searches were performed from February 2024-March 2026. Eligible studies provided ≥ 5 g of sodium bicarbonate within a 24-h period or, if a multi-day protocol, at least one day involving ≥ 5 g. Included studies had a placebo group/condition or a comparison group/condition that created a contrast related to delivery method, form, or dose. In total, 101 investigations were summarized in six categories: acute single dosing (n = 35); acute spread dosing …
Long Biogeographic Separation Corresponds With Fewer Herbivores On Eastern Asian Plants Introduced To Eastern North America, Robert Warren
Long Biogeographic Separation Corresponds With Fewer Herbivores On Eastern Asian Plants Introduced To Eastern North America, Robert Warren
Biology Faculty Datasets
No abstract provided.
The Role Of Full Femur Imaging For Early Detection Of Incomplete Atypical Femur Fractures, Ashley B. Humrickhouse, Donald Eagerton, Anne G. La Rochelle
The Role Of Full Femur Imaging For Early Detection Of Incomplete Atypical Femur Fractures, Ashley B. Humrickhouse, Donald Eagerton, Anne G. La Rochelle
South Atlantic Division GME Research Days 2026
No abstract provided.
Regrowth Of Thyroid Gland After Total Thyroidectomy, Amy Duff, Mikayla Kidd, Donald Eagerton
Regrowth Of Thyroid Gland After Total Thyroidectomy, Amy Duff, Mikayla Kidd, Donald Eagerton
South Atlantic Division GME Research Days 2026
No abstract provided.
When Covid Unmasks More Than Infection: A Case Of Post-Viral Lada, Mikayla Kidd, Amy Duff, Reggie Skains Iii, Sahana Parthasarathy
When Covid Unmasks More Than Infection: A Case Of Post-Viral Lada, Mikayla Kidd, Amy Duff, Reggie Skains Iii, Sahana Parthasarathy
South Atlantic Division GME Research Days 2026
No abstract provided.
Building A Cell Specific System For In Vivo Rna Imaging Of The Endogenous Actin Gene In C. Elegans, Jasmine A. Huerta Canete
Building A Cell Specific System For In Vivo Rna Imaging Of The Endogenous Actin Gene In C. Elegans, Jasmine A. Huerta Canete
Theses and Dissertations
Messenger RNA (mRNA) plays a crucial role in protein synthesis and cellular processes, important for the development of cells such as neurons. When dysregulation occurs, it can lead to outcomes such as aberrant translation, causing neurodegenerative conditions to arise. Unfortunately, the localization of mRNA in an in vivo cell specific manner is still not understood. To address this, we decided to develop a cell-specific system to image RNA in vivo, within the organism known as C. elegans with a focus on the actin gene. The Actin gene encodes for an important cytoskeleton protein expressed ubiquitously, vital for the cell …
Orexin Receptor Modulation In Amygdalar Stress Circuitry Differentiates Resilient And Vulnerable Phenotypes, Megan Marie John
Orexin Receptor Modulation In Amygdalar Stress Circuitry Differentiates Resilient And Vulnerable Phenotypes, Megan Marie John
Dissertations and Theses
Social stress is important for evaluating threats and resource opportunities, however, chronic exposure initiates the onset of psychological disorders, such as anxiety, depression, and post-traumatic stress disorder (PTSD). Stress responsiveness varies between individuals and sexes, resulting in disproportionate diagnoses and ineffective treatment outcomes. Enhancing therapeutic efficacy requires understanding of stress responsivity, phenotype development, and neurocircuitry modifications. Key contributors to stress responsiveness, such as threat of aggression and motivational initiation, influence the development of resilient or vulnerable phenotypes through behavioral and molecular adaptations to stress-related neurocircuitry. The basolateral amygdala (BLA) is a brain region associated with fear learning and integrates stress …
Varied Environmental Enrichment Schedules Differentially Affect Behavioral Performance, Davis Aschemann
Varied Environmental Enrichment Schedules Differentially Affect Behavioral Performance, Davis Aschemann
Research Honors
Cognitive decline is a widespread phenomenon affecting a significant proportion of older adults. The mechanisms that cause cognitive decline are still being investigated, with recent evidence indicating that senescent cells are a primary cause of neuroinflammation and neurodegeneration. Environmental enrichment has been linked with the potential curbing and reversal of cognitive decline, specifically the restoration of immune cell function and improved neuroplasticity. Despite the amount of research showing the beneficial effects of environmental enrichment for cognitive decline, paradigms for environmental enrichment are heterogeneous across the literature. A primary factor that differs across studies is the duration of administration of environmental …
The Effects Of Hyperthyroidism On Mouse Corneal Innervation: Implications For Human Cornea Re-Innervation, Anjali Malali
The Effects Of Hyperthyroidism On Mouse Corneal Innervation: Implications For Human Cornea Re-Innervation, Anjali Malali
Research Honors
To test the effects of elevated TH during cornea development, our lab has collaborated with Dr. Juan Davila (University of Illinois Urbana-Champaign) to develop an embryonic mouse model of hyperthyroidism. Embryos were exposed to high levels of TH in utero by adding TH to the pregnant mother’s drinking water. Upon collection of the embryos, elevated blood thyroid levels in the pregnant mother were analyzed with an enzyme-linked immunosorbent assay (ELISA), and eye tissues were collected and preserved for analysis of corneal nerve innervation patterns. By utilizing immunohistochemistry in order to visualize corneal innervation in mouse embryos, this project studied whether …
The Epidemiology Of Catastrophic Head And Neck Injuries In High School And College Non-Football Sports: A 4-Decade Review, Courtney M. Meyer, Kristen L. Kucera, Samantha E. Scarneo-Miller, Zachary K. Winkelmann, Susan W. Yeargin
The Epidemiology Of Catastrophic Head And Neck Injuries In High School And College Non-Football Sports: A 4-Decade Review, Courtney M. Meyer, Kristen L. Kucera, Samantha E. Scarneo-Miller, Zachary K. Winkelmann, Susan W. Yeargin
Rehabilitation Sciences Faculty Publications
Background:
Catastrophic head and neck injuries (CHNIs) in sport are rare but can have disabling or fatal outcomes. Prior studies have focused on football, equipment-laden sports, or different injury severities, not CHNI in nonfootball sports.
Purpose:
To describe the epidemiology of CHNI across levels (high school vs collegiate) in nonfootball sports and evaluate differences in injury rates (IRs) by sport, sex, and decade.
Study Design
Descriptive epidemiological study.
Methods:
This study utilized 40 academic years (1982-1983 to 2021-2022) of surveillance data from the National Center for Catastrophic Sports Injury Research. Descriptive statistics summarized athlete, event, and injury characteristics. IRs were …
Baseline Lymphopenia Predicts Survival In Ici-Naïve Solid Tumor Patients Receiving Immune Checkpoint Inhibitors: A Propensity-Matched Real-World Pan-Cancer Analysis, Ahmed Ismail, Nina Balanchivadze, George R. Simon, Yanis Boumber
Baseline Lymphopenia Predicts Survival In Ici-Naïve Solid Tumor Patients Receiving Immune Checkpoint Inhibitors: A Propensity-Matched Real-World Pan-Cancer Analysis, Ahmed Ismail, Nina Balanchivadze, George R. Simon, Yanis Boumber
Department of Medicine Faculty Publications
Background: Baseline lymphopenia is common among advanced solid tumors and may influence the efficacy/safety of immune checkpoint inhibitors (ICIs), but large real-world evidence is limited. We evaluated the association between baseline absolute lymphocyte count (ALC) and clinical outcomes in adults with solid tumors treated with ICIs in routine practice. Methods: We performed a retrospective cohort study using TriNetX. Adults with solid tumors who received pembrolizumab, nivolumab, or atezolizumab (ICI-Naïve) between January 2015 and June 2026 were included. Baseline ALC was measured within 30 days before first treatment and was classified as lymphopenic (ALC < 1.5 × 10⁹/L) or non-lymphopenic (ALC ≥ 1.5 × 10⁹/L). Propensity score matching (1:1) yielded 5249 patients per group. The index date was the first immunotherapy date, and outcomes were assessed at 6, 12, 24, 36 months, and 5 years. The primary outcome was 24-month overall survival (OS); secondary outcomes were OS at 6 and 12 months and 6-month risks of healthcare utilization, immune-related adverse events (irAEs), and serious infections; and exploratory outcomes included OS at 36 months and 5 years. All outcomes were analyzed using Kaplan–Meier analysis, Cox proportional hazards models, and risk ratios. Subgroup analysis included OS stratified by solid tumor subtypes and prior lines of therapy. Results: After matching, patients with baseline lymphopenia …